Dysregulation of mineral metabolism: association of albumin-corrected calcium and vitamin D with diabetic kidney disease in type 2 diabetes-a cross-sectional study.
Qiong Ma, Xue Li, Lin Liu, Fuqiang Liu, Ying Lv, Junkui Wang, Ting Wang
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引用次数: 0
Abstract
Background: Disturbances in calcium (Ca), vitamin D, and electrolyte balance have been implicated in diabetic kidney disease (DKD), yet existing evidence remains inconsistent. Moreover, the role of albumin-corrected Ca-a more accurate measure of biologically active Ca in patients with frequent hypoalbuminemia-remains poorly defined in type 2 diabetes mellitus (T2DM). We aimed to investigate the association between albumin-corrected Ca, vitamin D, electrolytes and DKD in a large T2DM cohort.
Methods: In this cross-sectional study, 5550 T2DM patients were enrolled, including 1574 participants with DKD. Multivariable regression analyses were used to assess the association between albumin-corrected Ca, vitamin D and DKD. Spearman's correlation analyses were conducted to examine the correlation between electrolyte levels, vitamin D and indicators of renal impairment.
Results: Patients with DKD in T2DM were older, predominantly male, with longer diabetes duration, higher blood pressure, poorly glycemic control and more diabetic complications compared to those without DKD. Notably, patients with DKD also showed significant electrolyte imbalances, suggesting dysregulated mineral metabolism. Multivariate logistic regression revealed albumin-corrected Ca (odds ratio [OR]: 4.032, 95% confidence interval [CI]: 2.017-8.062, P < 0.001), 1,25-(OH)2-VitD3 (OR: 0.967, 95% CI: 0.960-0.974, P < 0.001) were independently associated with DKD after accounting for confounding factors.
Conclusions: We demonstrated that elevated albumin-corrected Ca and decreased 1,25-(OH)2-VitD3 were significantly associated with DKD in T2DM patients. These findings suggest the potential of mineral metabolism parameters, particularly albumin-corrected Ca, to enhance early detection and risk stratification. Future prospective cohort studies are essential to establish a causal relationship and clarify their clinical therapeutic guidance value.
期刊介绍：
European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.
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