European Journal of Medical Research最新文献

{"title":"A new strategy for inflammatory regulation in sepsis: mechanisms and clinical progress of hemoperfusion techniques in correcting inflammatory homeostasis in sepsis.","authors":"Yanjie Cao, Zixian Song, Hong Liu","doi":"10.1186/s40001-026-03940-w","DOIUrl":"https://doi.org/10.1186/s40001-026-03940-w","url":null,"abstract":"<p><p>Sepsis has a high global morbidity and mortality rate. Its pathophysiological mechanisms are complex and can also adversely affect the function of multiple organ systems. Inflammation plays a crucial role in the development of sepsis. Early intervention and blockage of the inflammatory cascade in septic patients can improve their hemodynamics, remodel the homeostasis of the body's internal environment, and improve their prognosis, which has important social and economic benefits for both patients and society. Hemoperfusion combined with continuous renal replacement therapy (CRRT) shows unique advantages in removing inflammatory mediators and improving patients' organ function. This article reviews the pathophysiological mechanisms of sepsis, the application of hemoperfusion technology in septic patients, and recent research progress.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the profile of mild cognitive impairment among inpatients with T2DM: a comparison of the MMSE and MoCA.","authors":"Yamin Liu, Rehanguli Maimaitituerxun, Wenhang Chen, Letao Chen, Fang Xiao, Xin Yin Wu, Jianzhou Yang, Yuxin Tang, Wenjie Dai","doi":"10.1186/s40001-026-04107-3","DOIUrl":"https://doi.org/10.1186/s40001-026-04107-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify the differences in the profile of mild cognitive impairment (MCI) among inpatients with type II diabetes mellitus (T2DM) by using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).</p><p><strong>Method: </strong>This hospital-based cross-sectional study included consecutive T2DM in patients who were admitted to the Endocrinology Department of Xiangya Hospital Affiliated with Central South University from July 1, 2022, to December 31, 2022. Demographic characteristics, lifestyle information, medical history, and clinical features were collected using a standard questionnaire via face-to-face interviews by well-trained investigators. MCI was defined as the early stage of cognitive decline, and measured by MMSE and MoCA with education-specific cutoffs. Multivariate logistic regression analyses were used to determine factors associated with MCI detected by MMSE or MoCA.</p><p><strong>Results: </strong>A total of 474 participants were included. The prevalence of MCI detected by MMSE and MoCA was 18.4% and 51.9%, respectively. The MMSE had fair agreement with the MoCA for detecting MCI (kappa value = 0.287), and the MMSE score correlated significantly with the MoCA score (r_s = 0.82, P < 0.001). Age and diabetic nephropathy were associated with MCI by both MMSE and MoCA. Regular physical activity was only associated with MCI by the MMSE, educational level, household income, and stroke were only associated with MCI by the MoCA.</p><p><strong>Conclusions: </strong>The MoCA was more sensitive than the MMSE in screening for MCI among inpatients with T2DM, as it detected more MCI patients. However, cautious should apply since this might come at the cost of specificity, given the lack of a gold-standard diagnosis in this study. In addition to age, diabetic nephropathy, regular physical activity, educational level, household income, and stroke status were considered modifiable factors for MCI among inpatients with T2DM, which provides important evidence for establishing intervention measures.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of quality control circle interventions to reduce perioperative delirium in older adults with hip fractures: a pilot study.","authors":"Xiao-Fang Xu, Yu Zhang, Hai-Yan Gu","doi":"10.1186/s40001-026-04045-0","DOIUrl":"https://doi.org/10.1186/s40001-026-04045-0","url":null,"abstract":"<p><strong>Background: </strong>Delirium is a common perioperative complication among older adults undergoing surgery for hip fractures. It is associated with increased risks of recurrent fractures, prosthesis-related complications, such as loosening, breakage, or dislocation, and overall delayed recovery. The etiology of delirium is multifactorial, involving intrinsic and precipitating factors spanning physiological, psychological, and environmental domains. Quality control circle (QCC) activities, defined as collaborative, problem-solving initiatives led by teams with shared or complementary responsibilities, are designed to promote continuous improvements in healthcare quality.</p><p><strong>Objectives: </strong>The aim of this pilot study is to evaluate the effectiveness of QCC-based interventions in reducing the incidence of perioperative delirium among older adults with hip fractures.</p><p><strong>Methods: </strong>A double-blinded pilot study was conducted involving 90 older adults diagnosed with hip fractures between April 2022 and September 2023. Participants were assigned to either a control group (n = 46), receiving standard delirium management, or an intervention group (n = 44), which received additional QCC-based care strategies. Interventions included early mobilization, optimization of sleep duration and quality, cognitive and orientation support, and targeted delirium education for both patients and caregivers. Outcomes compared between groups included the incidence and duration of perioperative delirium, night-time sleep duration, and sleep quality index.</p><p><strong>Results: </strong>The incidence of perioperative delirium was lower in the intervention group (9.0%) compared to the control group (17.4%). The duration of delirium episodes was significantly shorter in the intervention group (p < 0.001). In addition, the intervention group demonstrated significantly longer nocturnal sleep durations (p < 0.001) and higher sleep quality index scores (p < 0.001) compared to the control group.</p><p><strong>Conclusions: </strong>The integration of QCC-based interventions was associated with a reduced incidence and duration of perioperative delirium in older adults with hip fractures. Improvements in sleep quality and night-time sleep duration were observed, indicating that QCC activities may contribute to enhanced postoperative recovery in this population. However, these findings should be interpreted with caution given the relatively small sample size and single-center design.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil activation, NETs formation, and inflammation in diabetic kidney disease: therapeutic perspectives.","authors":"Bingqian Deng, Lei Zhang, Yuan Liu, Mi Zhou, Jianfeng He","doi":"10.1186/s40001-026-04041-4","DOIUrl":"https://doi.org/10.1186/s40001-026-04041-4","url":null,"abstract":"<p><p>Diabetic kidney disease (DKD) represents the most common microvascular complication of diabetes mellitus and a principal driver of end-stage renal disease (ESRD). Recent studies have highlighted the central role of neutrophils in the pathogenesis and progression of DKD. Following aberrant activation, neutrophils infiltrate the renal interstitium, contributing to disease progression through the release of reactive oxygen species (ROS), pro-inflammatory cytokines, and chemokines, as well as the formation of neutrophil extracellular traps (NETs). Components associated with NETs, such as histones and myeloperoxidase (MPO), can directly activate renal inflammatory signaling cascades, thereby promoting tissue damage. Clinically, neutrophil-to-lymphocyte ratio (NLR) and neutrophil gelatinase-associated lipocalin (NGAL) serve as valuable biomarkers for the early detection and monitoring of DKD. Consequently, therapeutic strategies targeting neutrophil activation, NETs formation, and the associated inflammatory pathways are emerging as promising avenues for DKD treatment, including the use of PAD4 inhibitors and IL-1β blockers. Future research should continue to elucidate the intricate mechanisms governing NETs formation and resolution to facilitate the development of targeted therapies and the clinical translation of relevant biomarkers for DKD.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with non-curative resection and metachronous cancer after endoscopic submucosal dissection in patients with ulcerative early gastric cancer.","authors":"Yiping Xin, Yuning Chu, Qi Zhang, Xiaoyan Yin, Tao Mao, Xiaoyu Li","doi":"10.1186/s40001-026-03961-5","DOIUrl":"https://doi.org/10.1186/s40001-026-03961-5","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic submucosal dissection (ESD) has become a primary treatment for early gastric cancer (EGC). Ulcerative EGC is more prone to non-curative resection (NCR) during ESD due to its unique pathological characteristics, and such cases are also associated with an increased risk of metachronous gastric cancer (MGC) after treatment. This study aims to evaluate the risk factors associated with NCR and the development of metachronous cancer in patients with ulcerative EGC after ESD.</p><p><strong>Methods: </strong>We conducted a retrospective observational study on patients who underwent ESD for ulcerative EGC at the Affiliated Hospital of Qingdao University between 2015 and 2023. Univariate and multivariate logistic regression analyses were performed to identify risk factors associated with NCR after ESD, while univariate and multivariate Cox regression analyses were conducted to determine risk factors for the development of metachronous cancer following ESD.</p><p><strong>Results: </strong>A total of 182 patients with ulcerative EGC were enrolled in the study, among whom 25 cases were pathologically confirmed as NCR. Multivariate logistic regression analysis revealed that lesion size measuring 20-30 mm and an undifferentiated histologic type on preoperative biopsy were independent risk factors for NCR (OR = 3.65, 95% CI 1.51-8.91, P = 0.004; OR = 5.40, 95% CI 1.36 - 21.35, P = 0.018, respectively). Age ≥ 65 years (HR = 3.953, 95% CI 0.993-15.735, P = 0.041) and indistinct ulcer margins (HR = 4.385, 95% CI 1.092-17.603, P = 0.037) were identified as independent risk factors for the development of M GC following ESD in patients with ulcerative EGC.</p><p><strong>Conclusions: </strong>Lesion size of 20-30 mm and an undifferentiated histologic type on preoperative biopsy were identified as independent risk factors for NCR in patients with ulcerative EGC. In addition, older age and indistinct ulcer margins were significantly associated with an increased risk of MGC following ESD. Careful preoperative evaluation and long-term surveillance are essential for optimizing therapeutic outcomes in ulcerative EGC.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the dietary index for gut microbiota and post-stroke depression: a cross-sectional study.","authors":"Xiaoting Hu, Yu Ning, Yan Zhuang, Laifu Li, Fei Dai","doi":"10.1186/s40001-026-04112-6","DOIUrl":"https://doi.org/10.1186/s40001-026-04112-6","url":null,"abstract":"<p><strong>Background: </strong>Gut microbiota dysbiosis plays a critical role in the pathogenesis of post-stroke depression (PSD). The role of microbiota-targeted dietary patterns in PSD remains uncharacterized. This population-based study evaluated the Dietary Index for Gut Microbiota (DI-GM) and PSD prevalence relationship in U.S. adults.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from seven consecutive cycles (2005-2018) of the National Health and Nutrition Examination Survey (NHANES). Multivariable logistic regression assessed DI-GM-PSD associations, with restricted cubic splines (RCS) evaluating nonlinear trends. Stratified analyses assessed effect modification by demographic/clinical characteristics. Mediation analysis quantified the indirect effects of DI-GM on PSD through the mediator, body mass index (BMI).</p><p><strong>Results: </strong>Adjusted analyses showed a negative association between DI-GM scores and PSD, with higher scores concurrently linked to lower PSD prevalence. The DI-GM scores ranged from 0 to 14. In Q4 DI-GM (7-14), PSD risk was 60% lower vs. Q1 (0-4) (OR = 0.40, 95% CI 0.23-0.71, p = 0.002). RCS regression depicted a curvilinear pattern between DI-GM scores and PSD risk (nonlinearity p = 0.015). Stratified analyses showed that higher DI-GM scores were associated with significantly lower rates of PSD in females (OR = 0.83, 95% CI 0.74-0.94; p-interaction = 0.026), but not in males. Mediation analysis suggested BMI partially mediated the association between DI-GM and PSD risk (proportion mediated: 19.2%, p = 0.018).</p><p><strong>Conclusions: </strong>This study identified a negative association between DI-GM scores and the prevalence of PSD. Our findings suggest that dietary patterns beneficial to gut microbiota are associated with lower rates of PSD, and that this relationship is inter-related with BMI. These results highlight the potential clinical relevance of integrated dietary and weight management strategies, though longitudinal studies are needed to confirm any causal pathways.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ability of the continuous carotid Doppler patch to track directional changes in cardiac output in cardiac surgery patients.","authors":"Guang-Wei Hao, Dan-Lei Huang, Guo-Guang Ma, Ying Su, Jun-Yi Hou, Yi-Jie Zhang, Wen-Jun Liu, Zhi-Hui Lu, Zhe Luo, Guo-Wei Tu","doi":"10.1186/s40001-026-04034-3","DOIUrl":"https://doi.org/10.1186/s40001-026-04034-3","url":null,"abstract":"<p><strong>Background: </strong>Hands-free patch for continuous quantitative monitoring of common carotid artery (CCA) blood flow has gained interest in recent years. The aim of this study was to evaluate whether carotid minute distance (cMD), collected from a hands-free continuous wave Doppler, allows tracking directional changes incardiac output (CO) induced by passive leg raising (PLR) or dobutamine test in cardiac surgery patients.</p><p><strong>Methods: </strong>Cardiac surgery patients with pulmonary artery catheter or transpulmonary thermodilution monitoring were enrolled. Four-quadrant plot was adopted to evaluate the concordance between the percentage change of CCA cMD, which was the product of heart rate and velocity time integral, and invasive CO induced by PLR or dobutamine test.</p><p><strong>Results: </strong>A total of 41 cardiac surgery patients were enrolled and 82 pairs of invasive CO and cMD induced by the PLR or dobutamine test were collected in this study. Following the PLR test, significant increases were observed in CO (5.3 ± 1.1 vs. 5.7 ± 1.3 L/min, p﹤0.001). Similarly, dobutamine administration resulted in marked elevations of CO (5.3 ± 1.1 vs. 6.0 ± 1.3 L/min, p﹤0.001). Compared with baseline values, cMD demonstrated significant enhancement following both PLR test and dobutamine challenge. The concordance rate between percentage change of CO and cMD was 98.5%, with the coefficient of determination (R²) be 0.58 (p﹤0.001).</p><p><strong>Conclusions: </strong>In cardiac surgery patients, cMD collected from a hands-free CADFlow monitor system could reliably tracking directional changes of CO, with thermodilution technique be the reference method.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (NCT05944146). Registered July 12, 2023.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental value of novel immunonutritional-inflammatory markers over clinical models in predicting sepsis after ureteroscopic lithotripsy.","authors":"Hongmin Zhou, Jun Luo, Xiangcheng Zhan, Xudong Yao, Dujian Li, Tiancheng Xie, Yunfei Xu","doi":"10.1186/s40001-026-04026-3","DOIUrl":"https://doi.org/10.1186/s40001-026-04026-3","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is a serious complication after ureteroscopic lithotripsy (URSL), but its accurate pre-operative prediction remains difficult. This study aims to evaluate novel immunonutritional-inflammatory indices, which reflect the \"nutrition-immunity-inflammation\" axis, for predicting post-URSL sepsis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 569 patients undergoing URSL. Postoperative sepsis was diagnosed per Sepsis-3 criteria. A base clinical model was built using pre-operative variables from multivariate analysis. We then assessed the incremental predictive value of adding five indices (CALLY, PNI, CAR, NAR, NPAR) by evaluating discrimination (AUC), calibration, reclassification (NRI, IDI), and clinical utility (Decision Curve Analysis). A nomogram and web calculator were developed based on the CALLY-augmented model for clinical use.</p><p><strong>Results: </strong>Of 569 patients, 41 (7.2%) developed sepsis. The base model (including gender, platelet count, operation time, hydronephrosis, leukocyte esterase, and urine culture) had an AUC of 0.832. The CALLY index provided the most significant improvement, increasing the AUC to 0.918 (P = 0.007). The model with CALLY also showed superior reclassification (NRI = 0.404, IDI = 0.134; both P < 0.001) and significantly better fit (Likelihood Ratio Test P < 0.001). Decision curve analysis confirmed its greater net clinical benefit across practical risk thresholds.</p><p><strong>Conclusion: </strong>Immunonutritional-inflammatory indices, particularly the CALLY index, significantly improve the prediction of post-URSL sepsis over clinical factors alone. The developed tool enables personalized risk estimation, supporting precision medicine in perioperative care.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry, ChiCTR2400092429. Registered 15 November 2024. Retrospectively registered.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different early intervention strategies guided by GMOS, PDMS-2, or their combination on motor outcomes in preterm infants with PIVH: a randomized trial.","authors":"Suwei Ren, Ping Gan, Yanyan Cai, Honghua Jiang, Jing Lv, Jingjing Hu, Yanlin Liu, Qiaozhi Qin, Weiwei Hou, Yuan Lv","doi":"10.1186/s40001-026-04051-2","DOIUrl":"https://doi.org/10.1186/s40001-026-04051-2","url":null,"abstract":"<p><strong>Objective: </strong>Periventricular-intraventricular hemorrhage (PIVH) is a common and serious complication in preterm infants, significantly increasing the risk of adverse neurodevelopmental outcomes. This study aimed to investigate whether early intervention programs guided by the General Movement Optimality Score (GMOS), the Peabody Developmental Motor Scales-2 (PDMS-2), or their combination, are associated with superior motor development in preterm infants with PIVH compared to standard care.</p><p><strong>Methods: </strong>In this prospective, stratified, randomized controlled trial, 103 preterm infants (gestational age < 37 weeks) with PIVH were screened. After applying the inclusion and exclusion criteria, 75 infants were enrolled, stratified by hemorrhage severity, and randomly allocated to one of four intervention groups: a Control group receiving standard early intervention; a GMOS group receiving standard intervention plus GMOS-guided therapy; a PDMS-2 group receiving standard intervention plus PDMS-2-guided therapy; and a GMOS + PDMS-2 group receiving standard intervention plus therapy guided by both tools. The primary outcomes, Fine Motor Quotient (FMQ) and Gross Motor Quotient (GMQ), were assessed using the PDMS-2 at corrected age (CA) 6 and 12 months. GMOS and general movements (GMs) were also evaluated at CA 1 and 3 months.</p><p><strong>Results: </strong>The four groups were comparable at baseline regarding key demographic and perinatal factors, major neonatal morbidities, clinical course, and initial neuromotor assessment scores (all p > 0.05). While no significant differences were observed at CA 3 months, the GMOS + PDMS-2 group demonstrated a significantly higher FMQ than the Control group at CA 6 months (median difference: 7.5 points, p = 0.006). By CA 12 months, significant differences emerged among the groups (p < 0.001 for both FMQ and GMQ), with large effect sizes (η² > 0.21). The GMOS + PDMS-2 group significantly outperformed both the Control group (FMQ median difference: 11.5 points; GMQ: 9.0 points; p < 0.001) and the GMOS-only group (FMQ: 9.0 points; GMQ: 7.0 points; p < 0.001).</p><p><strong>Conclusion: </strong>A combined early intervention strategy, dynamically guided by both GMOS and PDMS-2, is associated with significantly superior motor outcomes at 12 months CA in preterm infants with mild PIVH compared to standard care or interventions guided by either tool alone, suggesting that this combined approach may represent a promising model for optimizing early motor outcomes at 12 months CA in this high-risk population.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive genomic profiling refines diagnosis and reveals clinically relevant alterations in pediatric Soft tissue sarcomas.","authors":"Jianwu Zhou, Xiaobin Deng, Liang Peng, Yifei Du, Jian Sun, Yao Zhang, Zijie Zhou, Chao Yang, Shan Wang","doi":"10.1186/s40001-026-04050-3","DOIUrl":"https://doi.org/10.1186/s40001-026-04050-3","url":null,"abstract":"<p><p>Pediatric soft tissue sarcomas (STS) are rare malignancies that present significant challenges in diagnosis and treatment. Comprehensive genomic profiling holds promise in addressing these challenges by revealing the molecular drivers of these tumors. In this study, we conducted DNA sequencing on 50 pediatric STS samples, encompassing a diverse range of histologies. Utilizing advanced sequencing technologies and analytical tools, we identified recurrent genetic alterations that may guide diagnostic and therapeutic strategies. The most frequent mutations included alterations in EWSR1-FLI1, TP53, KRAS, and IGF1R. Notably, 34% of patients harbored mutations in the RTK-RAS signaling pathway, and 11 previously unreported gene mutations were identified. Gene amplifications were more common in rhabdomyosarcoma, while gene fusions were predominantly observed in non-rhabdomyosarcoma subtypes, particularly Ewing sarcoma. Our analysis of cooperative mutations revealed four groups of co-occurring genetic alterations, with no evidence of mutually exclusive mutations. Clinically, we observed significant correlations between specific genetic mutations and clinical parameters, such as age at diagnosis and fibrinogen levels, providing insights into potential prognostic factors. These findings offer a detailed genetic landscape of pediatric STS, emphasizing the importance of genomic profiling in improving diagnostic accuracy and identifying new therapeutic targets for this rare cancer.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}