European Journal of Medical Research最新文献

{"title":"Fully endoscopic keyhole approach for intracranial aneurysm clipping: clinical outcomes and technical note.","authors":"Lulu Chen, Yuchun Shang, Yu Li, Xialin Zheng","doi":"10.1186/s40001-025-02594-4","DOIUrl":"https://doi.org/10.1186/s40001-025-02594-4","url":null,"abstract":"<p><strong>Background: </strong>Surgical clipping is often utilized to treat intracranial aneurysms. The application of the endoscopy and keyhole approach in neurosurgery is increasing gradually in intracranial aneurysm occlusion. The aim of this study is to evaluate the role of fully endoscopic keyhole approach in clipping of intracranial aneurysms.</p><p><strong>Methods: </strong>We retrospectively analyzed four cases of intracranial aneurysms, including three cases of middle cerebral artery bifurcation aneurysms (M1) and one case of anterior communicating aneurysms (ACoA). Among them, the anterior communicating aneurysm underwent fully endoscopic clipping via supraorbital keyhole approach and the middle cerebral aneurysms underwent fully endoscopic clipping via mini-pterional keyhole approach. The clipped aneurysms were evaluated by Digital Subtraction Angiography (DSA).</p><p><strong>Results: </strong>All patients had satisfactory cerebral aneurysm clipping via the endoscopic keyhole approach. There was no cerebral hemorrhage, cerebral infarction, cerebral vasospasm. One case of intracranial infection was cured by active anti-infection. No recurrence of aneurysms after 6 months of follow-up.</p><p><strong>Conclusion: </strong>With the advantages of the endoscopy and keyhole approach, the excellent visual field of the endoscope can reduce the influence of intracranial aneurysmal neck residual and perforating vessel. However, endoscopic clipping of intracranial aneurysms in narrow corridors requires a learning curve.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"333"},"PeriodicalIF":2.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of a novel prognostic nomogram for gallbladder cancer patients.","authors":"Rongqiang Liu, Chenxuan Zhang, Yankun Shen, Jianguo Wang, Jing Ye, Jia Yu, Weixing Wang","doi":"10.1186/s40001-025-02513-7","DOIUrl":"https://doi.org/10.1186/s40001-025-02513-7","url":null,"abstract":"<p><strong>Background: </strong>Gallbladder cancer (GBC) arises from the malignant transformation of epithelial cells that line the gallbladder mucosa. The likelihood of developing GBC escalates with advancing age, and the condition generally presents a dismal prognosis. Despite this, there is a limited amount of research focusing on the prognostic determinants linked to GBC. As a result, this study sought to create a nomogram for evaluating GBC prognostic factors.</p><p><strong>Methods: </strong>In this investigation, a total of 8,615 cases of GBC from the Surveillance, Epidemiology, and End Results (SEER) database spanning from 2000 to 2020 were collected. In a 7:3 ratio, these instances were randomly assigned to one of two groups: training or internal validation. To assess the impact of clinical variables on overall survival (OS) in patients with GBC, both univariate and multivariate Cox regression analyses were utilized. The clinical criteria established were used to develop a nomogram. The effectiveness of the nomogram was evaluated through several approaches, such as receiver operating characteristic (ROC) curves, decision curve analysis (DCA), calibration curves, and Kaplan-Meier (KM) analysis.</p><p><strong>Results: </strong>To predict the prognosis of GBC patients, a nomogram was created based on the following criteria: sex, rural-urban continuum, marital status, nodes, histology, radiation, chemotherapy, metastasis, age, surgery, and grade. The training set had an area under the curve for 1-year, 3-year, and 5-year OS of 0.79, 0.78, and 0.78, respectively. The DCA curves demonstrated that the model was clinically useful and well-corrected. Patients with GBC were categorized into high-risk and low-risk groups based on the median risk score. KM curves revealed a significantly lower survival rate for the high-risk group in comparison with the low-risk group (P < 0.001).</p><p><strong>Conclusions: </strong>Our model demonstrated strong predictive capabilities for the prognosis of GBC patients, thereby aiding in the refinement of treatment strategies for these individuals.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"331"},"PeriodicalIF":2.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis on the effectiveness and safety of venetoclax-based combination therapy with hypomethylation in acute myeloid leukemia.","authors":"Yi Wang, Yingying Chen, Dongdong Ji, Ling Ge, Yu Zhang, Lixia Liu, Lei Jiang, Fengbo Jin, Leiming Xia","doi":"10.1186/s40001-025-02571-x","DOIUrl":"https://doi.org/10.1186/s40001-025-02571-x","url":null,"abstract":"<p><p>The combined therapy strategy of venetoclax with hypomethylating agents (HMAs) has demonstrated encouraging efficacy in the treatment of acute myeloid leukemia (AML), particularly in elderly patients or those deemed unfit for standard treatments. However, due to differences in the research focuses of various research centers, the results have not yet comprehensively and systematically demonstrated the clinical significance of this treatment approach. Therefore, in this meta-analysis, we aimed to assess the effectiveness and safety of venetoclax in combination with HMAs for the treatment of AML. We included a total of 20 clinical studies that met the search criteria, including research focused on AML patients carrying FLT-3 and IDH mutations. Results revealed an overall response (OR) rate of 0.57 and a complete remission (CR)/complete remission with incomplete marrow recovery (CRi) rate of 0.52. Subgroup analyses indicated varying CR/CRi rates among patients with different genetic mutations, with the highest rate observed in IDH mutation carriers at 0.71, FLT-3 mutation carriers at 0.64, and TP53 mutation carriers at 0.44. Simultaneously, we observed adverse events such as anemia, neutropenia, and thrombocytopenia, underscoring the importance of careful management during venetoclax and HMAs treatment. This study emphasizes the potential of venetoclax and HMAs as a promising therapeutic approach for AML while highlighting the critical need for monitoring and managing adverse events in such treatment regimens.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"330"},"PeriodicalIF":2.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of prognostic model for ICU mortality in cardiac arrest patients: an interpretable machine learning modeling approach.","authors":"Yong Li, Ying Liu, Qing Zhang, Hongwei Zhu, Chengli Wen, Xian Jiang","doi":"10.1186/s40001-025-02588-2","DOIUrl":"https://doi.org/10.1186/s40001-025-02588-2","url":null,"abstract":"<p><strong>Background: </strong>The incidence and mortality of cardiac arrest (CA) is high. We developed interpretable machine learning models for early prediction of ICU mortality risk in patients diagnosed with CA.</p><p><strong>Methods: </strong>Data from the Medical Information Mart for Intensive Care (MIMIC-IV, version 2.2) was randomized to training set (0.7) and internal validation set (0.3), and data from eICU(version 2.0.1) was used as external validation set. Five models including Logistic Regression (LR), Random Forest (RF), K Nearest Neighbor (KNN), Decision Tree (DT), and Extreme Gradient Boost (XGBoost) were developed. The model with the largest area under the Receiver Operating Characteristic (ROC) curve (AUC) and good performance in other features was defined as the best model, and Shapley Additive Explanations (SHAP) was used to improve the interpretability of the optimal model.</p><p><strong>Results: </strong>A total of 1088 patients from MIMIC-IV, and 3542 patients from eICU were included. Seven variables were selected to construct models by Least Absolute Shrinkage and Selection Operator (LASSO) regression. The RF model was the best predictive model with AUC and 95% CI at 0.83 (0.78-0.88) in internal validation set, and 0.71(0.68-0.74) in external validation set. SHAP analysis found that the variables that had a high impact on the risk of ICU death were minimal Glasgow Coma Scale (GCS), base excess, anion gap, and urine output.</p><p><strong>Conclusion: </strong>RF is the optimal model for predicting the risk of ICU death in CA patients. The development of this model is important for early identification and intervention of CA patients who are at risk of dying in the ICU.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"328"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review.","authors":"Matej Pekar, Piotr Branny, Otakar Jiravsky, Radim Spacek, Jan Alexander Mohr, Ivan Ranic, Bogna Jiravska Godula, Alica Cesnakova Konecna, Marek Kantor, Jan Hecko, Radek Neuwirth, Libor Sknouril, Jan Novak","doi":"10.1186/s40001-025-02587-3","DOIUrl":"10.1186/s40001-025-02587-3","url":null,"abstract":"<p><p>Transcatheter Aortic Valve Implantation (TAVI) has revolutionized severe aortic stenosis treatment, but risk stratification remains challenging. This systematic review examined the association between computed tomography (CT)-derived adipose tissue parameters and TAVI outcomes. We searched major databases for studies on visceral (VAT), subcutaneous (SAT), and intramuscular (IMAT) adipose tissue parameters and post-TAVI outcomes. Fourteen studies (9692 patients) were included. Higher SAT area/volume was consistently associated with better survival (5 studies, HR range: 0.83-2.77, p < 0.05). Lower SAT and VAT density also correlated with better survival (5 and 4 studies, respectively, HR range: 1.31-1.46, p < 0.05). VAT area showed mixed results. A VAT:SAT ratio < 1 was associated with better cardiovascular outcomes in one study. Lower IMAT index correlated with shorter hospital stays in a single study. This review reveals complex relationships between adipose tissue parameters and TAVI outcomes. Lower adipose tissue density and higher subcutaneous adiposity were most consistently associated with better outcomes. These findings suggest that detailed analysis of adipose tissue characteristics may enhance risk stratification in TAVI candidates.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"325"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between naples prognostic score and stroke and mortality among older adults.","authors":"Junting Song, Lin Yin","doi":"10.1186/s40001-025-02613-4","DOIUrl":"https://doi.org/10.1186/s40001-025-02613-4","url":null,"abstract":"<p><strong>Background: </strong>Inflammation and malnutrition in the body are closely related to the incidence of stroke. Older adults often suffer from malnutrition and inflammation. Naples Prognostic Score (NPS), a novel inflammation-malnutrition score, can effectively assess the inflammation and nutritional status of the body. The aim of this study is to explore the connection between NPS and stroke among older adults, as well as the association between NPS and mortality in older adults.</p><p><strong>Methods: </strong>Participants eligible for the study were collected from National Health and Nutrition Examination Survey(NHANES) data from 1999 to 2018. Logistic regression models were employed to investigate the link between NPS and stroke. Additionally, restricted cubic spline was utilized to explore the correlations. Subgroup analysis was adopted in order to ensure the credibility of the results. Kaplan-Meier Survival curve and cox regression models and were utilized to evaluate the link between NPS and mortality among older adults.</p><p><strong>Results: </strong>16,940 older adults qualified for analysis. The participants with stroke had higher levels of NPS. In the logistic regression model, NPS was positively related to stroke (high NPS vs. low NPS, OR = 1.70 (95% CI 1.24-2.35), P < 0.001). Restricted cubic spline revealed a positive non-linear relationship (P for overall < 0.001, P for non-linear < 0.001). Subgroup analysis showed that the association between NPS and the incidence of stroke is more significant in the non-diabetes population (P < 0.001). The Kaplan-Meier curve shows that patients with high NPS have a significantly higher risk of all-cause mortality and cardiovascular mortality (P < 0.001). In the Cox regression model, a positive correlation was observed between NPS and mortality among older adults (all-cause mortality: HR = 1.36 (95% CI 1.30-1.42); cardiovascular mortality:HR = 1.59 (95% CI 1.45-1.75)).</p><p><strong>Conclusions: </strong>A positive link was observed between NPS and stroke and mortality. Routine NPS screening may enhance risk stratification in geriatric clinics.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"327"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia.","authors":"Jiaming Liu, Tao Qing, Mei He, Liu Xu, Zhuxiang Wu, Meiting Huang, Zheyu Liu, Ye Zhang, Zisheng Li, Wenhui Yang, Junbo Liu, Jie Li","doi":"10.1186/s40001-025-02596-2","DOIUrl":"https://doi.org/10.1186/s40001-025-02596-2","url":null,"abstract":"<p><p>With high disability and mortality rate as well as highly complex pathogenesis, cerebral ischemia is highly morbid, prone to recurrence. To comprehensively understand the pathophysiological process of cerebral ischemia and to find new therapeutic strategies, a new approach to cerebral ischemia transcriptomics has emerged in recent years. By integrating data from multiple levels of transcriptomics, such as transcriptomics, single-cell transcriptomics, and spatial transcriptomics, this new approach can provide powerful help in revealing the molecular mechanisms of cerebral ischemia occurrence and development. Key findings highlight the critical roles of inflammation, blood-brain barrier dysfunction, and mitochondrial dysregulation in cerebral ischemia, offering potential biomarkers and therapeutic targets for early diagnosis and personalized treatment. A review of the research progress of cerebral ischemic injury mechanism under the analysis of the comprehensive transcriptomics research method was presented in this article, aiming to study the potential mechanism to provide new, innovative therapeutic strategies for this disease.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"326"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late neurological improvement during hospitalization is a predicative factor for acute ischemic stroke.","authors":"Huimin Zhao, Qinrong Xu, Peng Chen, Xiaojing Guo, Guanhui Wu","doi":"10.1186/s40001-025-02469-8","DOIUrl":"https://doi.org/10.1186/s40001-025-02469-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate whether late neurological improvement (LNI) during hospitalization serves as a favorable prognostic indicator in patients with acute ischemic stroke (AIS) and to identify the predictors of LNI.</p><p><strong>Methods: </strong>We retrospectively analyzed data from the Safe Implementation of Treatments in Stroke (SITS) registry at two stroke centers in Egypt. LNI was defined as the lack of early neurological improvement (ENI) within 24 h after admission, accompanied by neurological improvement within 7 days of hospitalization. Multivariate logistic regression was employed to analyze the factors influencing favorable prognosis (modified Rankin Scale score 0-2) and LNI.</p><p><strong>Results: </strong>A total of 834 patients with AIS were included in this study, of which 130 (15.6%) exhibited LNI. Among these, 99 (76.2%) achieved favorable outcomes. Both ENI (OR = 6.756, 95% CI 3.355-13.603, P < 0.001) and LNI (OR = 5.760, 95% CI 3.146-10.545, P < 0.001) were independently associated with favorable prognosis after adjustment. Predictors of LNI in multivariable-adjusted logistic regression included younger age (OR = 0.973, 95% CI 0.957-0.990, P = 0.001), higher baseline National Institutes of Health Scale (NIHSS) score (OR = 1.196, 95% CI 1.146-1.248, P < 0.001), and rt-PA treatment (OR = 1.953, 95% CI 1.206-3.163, P = 0.006).</p><p><strong>Conclusions: </strong>Approximately three-quarters of patients with LNI are expected to achieve good outcome. LNI was a favorable prognostic indicator in patients with AIS and younger age, higher baseline NIHSS score and rt-PA treatment predicted LNI.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"324"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation and analysis of personality characteristics of primary palmar hyperhidrosis patients: a cross-sectional observational study.","authors":"Xiaoyu Wang, Shushi Meng, Yuqing Huang, Jun Chen","doi":"10.1186/s40001-025-02575-7","DOIUrl":"10.1186/s40001-025-02575-7","url":null,"abstract":"<p><strong>Background: </strong>Patients with primary palmar hyperhidrosis (PPH) may exhibit distinct personality traits that influence their perception of the condition. These traits can manifest as heightened sensitivity to physical symptoms, as well as feelings of anxiety or depression, especially in social settings.</p><p><strong>Methods: </strong>This study is a retrospective cross-sectional observational study aimed to evaluate and analyze the personality characteristics of patients with primary palmar hyperhidrosis using the Personality Diagnostic Questionnaire-Version 4 (PDQ-4). This study explored the relationships between personality traits and various factors, including age, gender, body mass index (BMI), onset age, the age when symptoms began to impact daily life (Impact age), the choice of thoracic sympathectomy nerve segment, and postoperative satisfaction. The study enrolled primary palmar hyperhidrosis patients treated at the Thoracic Surgery Department of Beijing Haidian Hospital between 2016 and 2021, with a total of 791 patients meeting the inclusion criteria. Statistical analyses, such as the Chi-square test and Mann-Whitney U-test, were conducted using SPSS 26.0 to investigate associations between personality traits and various variables.</p><p><strong>Results: </strong>Primary palmar hyperhidrosis patients exhibited a higher prevalence of personality disorders at 16.18% compared to the general population, which ranges from 6.1 to 9.5%. Male patients exhibited a statistically significantly higher prevalence of schizoid, narcissistic, and antisocial personality disorders compared to female patients (P < 0.05). Furthermore, postoperative satisfaction among patients with primary palmar hyperhidrosis declined over time, with a statistically significant difference (P < 0.05). Notably, primary palmar hyperhidrosis patient comorbid personality disorders experienced a more pronounced decline in satisfaction.</p><p><strong>Conclusions: </strong>Patients with primary palmar hyperhidrosis demonstrate a relatively high prevalence of personality disorders.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"323"},"PeriodicalIF":2.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid-free anesthesia in bariatric surgery: a prospective randomized controlled trial.","authors":"Christine Dagher, Rhea Mattar, Marie Aoun, Joanna Tohme, Nicole Naccache, Hicham Jabbour","doi":"10.1186/s40001-025-02565-9","DOIUrl":"10.1186/s40001-025-02565-9","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgeries are increasingly used to manage obesity, presenting significant perioperative challenges, especially with opioid use. Opioid-Free Anesthesia (OFA) is a multimodal technique to address these issues. This study aims to compare the effects of OFA and traditional Opioid-Based Anesthesia (OBA) on postoperative morphine consumption, hemodynamics, pain, postoperative nausea and vomiting (PONV), sedation, and patient satisfaction in bariatric surgery.</p><p><strong>Methods: </strong>A prospective controlled study was conducted in the operating room of a tertiary university hospital. It included patients aged between 18 and 65 years undergoing bariatric surgery. 58 obese patients were divided into two groups: 32 received OBA and 26 received OFA. The OFA regimen included lidocaine, ketamine, magnesium sulfate, dexmedetomidine, and dexamethasone. Main outcome measures included postoperative morphine consumption in the Post-Anesthesia Care Unit (PACU), 24 and 48 h after surgery. Secondary outcomes included hemodynamic parameters, sedation score, pain score, presence of nausea and/or vomiting, and overall patient satisfaction evaluated at 48 h postoperatively or before hospital discharge were recorded.</p><p><strong>Results: </strong>OFA significantly reduced postoperative morphine consumption (median dose of 8 mg vs.19 mg, p = 0.000). Visual analogue scale (VAS) scores for pain at rest, during movement, and during coughing were significantly lower in the OFA group. Both groups were hemodynamically stable perioperatively. There was no significant difference in PONV incidence or sedation levels between the groups in the PACU, 24 and 48 h after surgery. Patient satisfaction was higher in the OFA group, with 65% reporting a satisfaction score of ≥ 8/10 compared to 28% in the OBA group.</p><p><strong>Conclusions: </strong>OFA reduces postoperative morphine consumption and improves pain management without compromising hemodynamic stability or increasing sedation. Furthermore, the incidence of PONV was not significantly different and overall patient satisfaction was higher with OFA. These findings support the use of OFA in bariatric surgery, despite the need for further studies with larger sample sizes.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"320"},"PeriodicalIF":2.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}