肝硬化患者骨骼肌异常与睡眠障碍负相关:一项横断面研究。

IF 3.4 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Shuangzhe Yao, Binbin Peng, Wenqin Liu, Jie Yang, Yangyang Hui, Chao Sun
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引用次数: 0

摘要

背景:肝硬化,尤其是失代偿期,与包括睡眠障碍在内的严重并发症相关。肝硬化患者睡眠质量与肌肉异常之间的关系尚不明确。本研究旨在调查匹兹堡睡眠质量指数(PSQI)定义的睡眠障碍与骨骼肌异常(包括肌肉减少症和肌骨化病)在失代偿肝硬化患者队列中的关系。方法:我们对505例成年失代偿性肝硬化患者进行了横断面分析,排除了恶性肿瘤、急性慢性肝衰竭、严重肝性脑病或数据不完整的患者。肌肉状态分别通过计算机断层扫描(CT)上的骨骼肌指数(SMI)和肌内脂肪组织含量(IMAC)来确定。结论:骨骼肌异常是肝硬化患者睡眠障碍的独立危险因素,因此需要有针对性的干预措施来缓解肌肉异常,并有可能提高这一脆弱人群的睡眠质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Skeletal muscle abnormalities negatively linked to sleep disturbances in patients with liver cirrhosis: a cross-sectional study.

Background: Liver cirrhosis, particularly in its decompensated stage, is associated with significant complications, including sleep disturbances. The relationship between sleep quality and muscle abnormality in patients with cirrhosis remains elusive. This study aimed to investigate the association between the Pittsburgh Sleep Quality Index (PSQI)-defined sleep disturbances and skeletal muscle abnormalities, including sarcopenia and myosteatosis, in a cohort of patients with decompensated cirrhosis.

Methods: We conducted a cross-sectional analysis of 505 adult patients with decompensated cirrhosis, excluding those with malignancy, acute-on-chronic liver failure, severe hepatic encephalopathy, or incomplete data. Muscle status was determined by the skeletal muscle index (SMI) and intramuscular adipose tissue content (IMAC) on computed tomography (CT), respectively.

Results: The median PSQI score was significantly higher in patients with coexistent sarcopenia and myosteatosis compared to those with no or isolated muscle abnormality (P < 0.001). Multivariate analysis revealed that concomitant muscle abnormalities (OR: 3.48, P = 0.029) and body mass index (BMI) (OR: 0.95, P = 0.040) as independent predictors of poor sleep quality. Additionally, in the subgroup with preserved liver function and younger age, the differences in PSQI score across various states of skeletal muscle are more pronounced.

Conclusion: Skeletal muscle abnormalities are an independent risk factor for sleep disturbances in cirrhotic patients, highlighting the need for targeted interventions to mitigate muscle abnormalities and potentially enhance sleep quality in this vulnerable population.

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来源期刊
European Journal of Medical Research
European Journal of Medical Research 医学-医学:研究与实验
CiteScore
3.20
自引率
0.00%
发文量
247
审稿时长
>12 weeks
期刊介绍: European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.
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