The protective effect of probiotic/prebiotic consumption against fatigue in the general population is modulated by BMI: an analysis of mediating and moderating effects based on NHANES.

IF 3.4 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Yan Wang, Zhimeng Yu, Huan Zhang, Zhusong Mei, Lei Wang, Chongxi Fan, Yan Wu, Minghao Yang, Yongquan Shi, Lei Shang, Zheyi Han
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引用次数: 0

Abstract

Objectives: Fatigue is closely linked to gut microbiota dysbiosis, making probiotics and prebiotics promising candidates for interventions related to fatigue. This study explores the relationship between probiotic/prebiotic consumption and fatigue in the general population, focusing on potential moderating and mediating factors, as most prior research has centered on clinical populations with secondary fatigue.

Methods: This study is a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018, and it included 3,791 US residents without underlying health conditions. Fatigue was assessed using the Patient Health Questionnaire-9 (PHQ-9), and probiotic/prebiotic consumption was evaluated via a 30-day dietary supplement questionnaire. Statistical analyses included weighted logistic regression to examine associations, and mediation/moderation models to assess the roles of BMI, sleep duration, depression scores, and exercise hours.

Results: A total of 3,791 participants were included in the study, with 46.6% self-reporting fatigue. Probiotic/prebiotic consumers had a significantly lower fatigue risk (OR = 0.738, 95% CI 0.735-0.741, p < 0.001). Among the mediating and moderating factors analyzed, only BMI was found to weakly but significantly moderate the association between probiotic/prebiotic consumption and fatigue, with higher BMI strengthening the association of probiotics and/or prebiotics intake with reduced fatigue odds (p = 0.039).

Conclusions: These findings indicate that the consumption of probiotics/prebiotics is correlated with a decreased risk of fatigue in the general population, and this association is further reinforced in individuals with a higher BMI.

益生菌/益生元消费对普通人群疲劳的保护作用是由BMI调节的:基于NHANES的中介和调节效应分析。
目的:疲劳与肠道菌群失调密切相关,益生菌和益生元有望成为干预疲劳的候选者。本研究探讨了益生菌/益生元消耗与一般人群疲劳之间的关系,重点关注潜在的调节和中介因素,因为大多数先前的研究都集中在临床人群中继发性疲劳。方法:本研究是一项横断面分析,使用了2009年至2018年国家健康与营养检查调查(NHANES)的数据,其中包括3,791名没有潜在健康状况的美国居民。使用患者健康问卷-9 (PHQ-9)评估疲劳,并通过30天膳食补充剂问卷评估益生菌/益生元的消耗。统计分析包括加权逻辑回归来检验相关性,以及中介/调节模型来评估BMI、睡眠时间、抑郁评分和锻炼时间的作用。结果:共有3791名参与者被纳入研究,其中46.6%的人自我报告疲劳。益生菌/益生元消费者的疲劳风险显著降低(OR = 0.738, 95% CI 0.735-0.741, p)。结论:这些发现表明,在一般人群中,益生菌/益生元的摄入与疲劳风险降低相关,这种关联在BMI较高的人群中进一步加强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Journal of Medical Research
European Journal of Medical Research 医学-医学:研究与实验
CiteScore
3.20
自引率
0.00%
发文量
247
审稿时长
>12 weeks
期刊介绍: European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.
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