{"title":"Role of long non-coding RNAs in cartilage development and osteoarthritis pathogenesis.","authors":"Xuejiao Sun, Shan Wang, Jun Tian, Mingxing Li","doi":"10.1186/s40001-025-03173-3","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoarthritis (OA) is a progressive joint disease characterized by the degradation of cartilage, remodeling of subchondral bone, and inflammation of synovial tissue, posing growing global health challenges. Long non-coding RNAs (lncRNAs) play crucial roles in various physiological and pathological processes associated with OA, including extracellular matrix (ECM) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. Chondrogenesis involves mesenchymal cell condensation followed by differentiation into chondrocytes, hypertrophy of chondrocytes, and subsequent maturation. This review aims to provide an updated overview of lncRNAs and their involvement in cartilage development as well as OA. Furthermore, we discuss the potential utility of lncRNAs as molecular biomarkers for early diagnosis and treatment of OA.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"900"},"PeriodicalIF":3.4000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482591/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Medical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40001-025-03173-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoarthritis (OA) is a progressive joint disease characterized by the degradation of cartilage, remodeling of subchondral bone, and inflammation of synovial tissue, posing growing global health challenges. Long non-coding RNAs (lncRNAs) play crucial roles in various physiological and pathological processes associated with OA, including extracellular matrix (ECM) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. Chondrogenesis involves mesenchymal cell condensation followed by differentiation into chondrocytes, hypertrophy of chondrocytes, and subsequent maturation. This review aims to provide an updated overview of lncRNAs and their involvement in cartilage development as well as OA. Furthermore, we discuss the potential utility of lncRNAs as molecular biomarkers for early diagnosis and treatment of OA.
期刊介绍：
European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.
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