European Journal of Medical Research最新文献

{"title":"Telitacicept alleviates IgA nephropathy by targeting PDHA1 lactylation to inhibit B cell metabolic reprogramming and lactate-mediated renal injury.","authors":"Lu Xu, Jing-Jing Zhang, Wen-Ting Xu","doi":"10.1186/s40001-026-04175-5","DOIUrl":"https://doi.org/10.1186/s40001-026-04175-5","url":null,"abstract":"<p><strong>Background: </strong>Immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis, is driven by galactose-deficient IgA1 (Gd-IgA1) production from autoreactive B cells. Current therapies inadequately target core pathogenic mechanisms. Telitacicept (a recombinant fusion protein inhibiting BLyS/APRIL) shows clinical promise, but its molecular mechanisms in modulating B cell metabolism and lactylation-mediated pathways remain unclear.</p><p><strong>Methods: </strong>IgAN patients and healthy controls were enrolled; B cells were isolated for metabolic flux analysis (OCR/ECAR), lactylation assays (IP/WB/LC-MS/MS), and PDH activity tests. Patients received Telitacicept (160 mg/week) or placebo. Murine IgAN models were established and Telitacicept (1 or 5 mg/kg) was administered. Co-cultures of IgAN patient B cells and human mesangial cells (HMCs) assessed lactate's role in renal injury. Site-directed mutagenesis (PDHA1-K336R) and siRNA knockdown (SIRT3/PDHA1) validated functional mechanisms.</p><p><strong>Results: </strong>IgAN patient B cells exhibited hyperlactylation of PDHA1 at lysine 336 (K336la), which suppressed pyruvate dehydrogenase (PDH) activity, elevated lactate production, and drove metabolic reprogramming toward glycolysis. This promoted IgA1 secretion and renal dysfunction. Telitacicept, a dual BAFF/APRIL inhibitor, significantly reduced PDHA1-K336la levels, restored PDH activity and OXPHOS, and suppressed lactate/IgA1 production. Mechanistically, Telitacicept upregulated the mitochondrial deacylase SIRT3, which directly bound PDHA1. SIRT3 knockdown abolished Telitacicept's effects. Critically, lactate from IgAN B cells triggered HMC inflammation, fibrosis, and apoptosis, effects reversed by Telitacicept but restored by exogenous lactate. In vivo, Telitacicept dose-dependently attenuated renal injury, fibrosis, and mortality in IgAN rats, while PDHA1 depletion exacerbated B cell metabolic dysfunction and renal damage.</p><p><strong>Conclusion: </strong>Telitacicept confers renoprotection by inducing SIRT3-dependent PDHA1 delactylation to reverse metabolic reprogramming in IgAN. Targeting the PDHA1 lactylation-SIRT3 axis represents a novel therapeutic strategy for IgAN and related autoimmune disorders.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-associated fibroblast-derived exosomal LINC00930 represses cell malignancy and glycolysis by recruiting MBNL1 and elevating PRKAA2 stability in colorectal cancer.","authors":"Chunhui Cui, Lifeng Wang, Jinlong Yu, Changhui Yu, Huiyan Zhang","doi":"10.1186/s40001-026-04022-7","DOIUrl":"https://doi.org/10.1186/s40001-026-04022-7","url":null,"abstract":"<p><p>Exosomes (EXOs) secreted by cancer-associated fibroblasts (CAFs) can induce malignant phenotypes of tumor cells. The long non-coding RNA LINC00930 is known for promoting cancer cell glycolysis and proliferation. However, its role and mechanism in colorectal cancer (CRC) are unclear. This study aimed to determine whether CAF-derived exosomal LINC00930 is involved in CRC progression. In our study, LINC00930 was significantly downregulated in CRC samples and cell lines, as well as in CAFs and CAF-derived EXOs. Functionally, CAF-derived exosomal LINC00930 inhibited CRC cell proliferation, migration, invasion, and glycolysis in vitro and impaired tumor growth in patient-derived xenograft models. LINC00930 improved PRKAA2 stability by recruiting MBNL1. Furthermore, PRKAA2 silencing partly reversed CAF-derived exosomal LINC00930-mediated effects on CRC cell proliferation, migration, invasion, and glycolysis. In conclusion, this study identifies LINC00930 as a tumor-suppressive lncRNA delivered by CAF-derived EXOs that inhibits CRC progression through the MBNL1-PRKAA2 axis, suggesting that LINC00930 could be a viable therapeutic target for CRC.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaped association between cardiometabolic index and depressive symptoms: a population-based cross section study of U.S. adults.","authors":"Zhihong Yu, Wei Li, Meng Wang, Shu Wang, Chao Yu","doi":"10.1186/s40001-026-04160-y","DOIUrl":"https://doi.org/10.1186/s40001-026-04160-y","url":null,"abstract":"<p><strong>Background: </strong>Research reports on the relationship between cardiometabolic index (CMI) and depressive symptoms are limited. This study aimed to evaluate the possible relationship between CMI and depressive symptoms.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of adults from the National Health and Nutrition Examination Survey (NHANES). Participants aged ≥ 18 years with complete data on CMI and depressive symptoms from the 2007-2018 cycles were included (n = 7965). Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) with a score ≥ 10 as the cut-off. Multivariable logistic regression models were used to assess the association. Restricted cubic splines (RCS) and logistic regression were employed to explore nonlinearity and identify inflection points. Subgroup analyses were performed to examine effect modification.</p><p><strong>Results: </strong>Of 7965 individuals, 637 (8%) had depressive symptoms, while hypertension and stroke are present in 3039 (38.15%) and 216 (2.71%), respectively. A multivariable logistic regression model observed that When LnCMI is employed as a classification variable, no significant association between them can be observed. A dose-response fitting curve find that there is a nonlinear J-shaped association between LnCMI and depressive symptoms. A two-piecewise logistic regression model to analyze their relationship, which we observed that CMI on the left side of the cut-off point was not associated with depressive symptoms prevalence. However, among patients with LnCMI ≥ -2, there was a positive association between LnCMI and depressive symptoms prevalence (OR 1.92; 95% CI 1.40-2.64). Subgroup analysis revealed that only BMI had a moderating effect on the association between CMI and depressive symptoms (OR:2.37,95% CI 1.53-3.67; P for interaction = 0.017).</p><p><strong>Conclusion: </strong>Our research findings suggest a strong association between higher CMI levels and increased prevalence of depressive symptoms, particularly among American adults with BMI ≥ 25 kg/m². We further revealed a turning point by threshold effect analysis.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative prediction of metachronous liver metastasis in colorectal cancer using a deep learning-based radiomics model with automatic segmentation: a multicenter study.","authors":"Wei Guo, Chang Rong, Datian Su, Baichuan Mu, Cuiping Li, Kaicai Liu, Xiaomin Zheng, Shuai Li, Xiaoer Zhao, Bo Cao, Yinzhong Chen, Xingwang Wu","doi":"10.1186/s40001-026-04132-2","DOIUrl":"https://doi.org/10.1186/s40001-026-04132-2","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and validate an integrated clinical-radiomics nomogram predicting the risk of metachronous liver metastasis (MLM) in patients with colorectal cancer (CRC).</p><p><strong>Methods: </strong>In this multicenter retrospective study, 518 CRC patients underwent nnU-Net-based automatic segmentation of CT images. Radiomic features from CRC and liver regions were extracted and selected using LASSO regression. Independent clinical predictors were identified through multivariate logistic regression. Clinical, radiomic, and combined clinical-radiomic models were developed and independently validated in the training, validation, and test cohorts. Model performance was evaluated using the area under the curve (AUC), concordance index (C-index), and calibration. Feature importance was interpreted with SHapley Additive exPlanations (SHAP), and survival differences were analyzed using Kaplan-Meier curves.</p><p><strong>Results: </strong>The nnU-Net demonstrated high segmentation accuracy (CRC DSC: 86.2% validation, 81.0% test; liver DSC: 96.5% validation, 94.7% test). AFP, dissected lymph nodes, perineural invasion, and tumor nodules were independent predictors. The combined model outperformed individual models (AUC: 0.972/0.875/0.814; C-index: 0.819/0.728/0.690; P < 0.05). SHAP analysis highlighted lymph node count, AFP, tumor nodules, and multiregional radiomics features as key contributors. High-risk patients exhibited a markedly reduced MLM-free survival (log-rankP < 0.0001) with good calibration.</p><p><strong>Conclusion: </strong>An automatic segmentation model based on deep learning enables accurate delineation of CRC and liver regions. Furthermore, clinical-radiomic nomogram demonstrates high accuracy in identifying patients at elevated risk of metachronous liver metastasis, thereby supporting clinicians in optimizing therapeutic strategies and facilitating personalized treatment planning.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the surrogate markers of insulin resistance and the mean blood glucose fluctuation amplitude in type 2 diabetic patients with different BMIs.","authors":"Limin Zhai, Nan Chen, Yue Wang, Tianrong Pan","doi":"10.1186/s40001-026-04125-1","DOIUrl":"https://doi.org/10.1186/s40001-026-04125-1","url":null,"abstract":"<p><strong>Background: </strong>The mean amplitude of glycemic excursions (MAGE) is considered the \"gold standard\" for assessing glycemic variability. Surrogate markers for insulin resistance (IR) have been proposed. We aim to explore the associations between surrogate markers of IR and MAGE in type 2 diabetic patients with different body mass indices (BMIs).</p><p><strong>Methods: </strong>A retrospective analysis of the clinical data of 309 hospitalized patients with type 2 diabetes was conducted. Patients were divided into two groups on the basis of whether their MAGE level was within the target range (< 3.9 mmol/l). Patients were categorized into two subgroups on the basis of BMI (BMI < 23 nonoverweight people and BMI ≥ 23 overweight people). Each surrogate marker of the IR was divided into three groups according to the interthird spacing of our specific research population and the level and achievement rate of MAGE differences among the three groups were compared. Multivariate logistic regression was used to assess the associations between surrogate markers of IR and MAGE.</p><p><strong>Results: </strong>(1) Compared with the nontargeted MAGE group, the target group presented statistically significant differences in BMI,2-h postprandial blood glucose (2 h-PG), triglyceride(TG), the triglyceride‒glucose index (TyG), and the homeostasis model assessment of IR on the basis of C-peptide (HOMA2‒IR),(all P < 0.01). (2) In the subgroup with BMI < 23, there were statistically significant differences in MAGE levels among all the IR surrogate marker groups(all p < 0.05), and the triglyceride‒glucose‒body mass index (TyG‒BMI) groups presented differences in the achievement rates of the target MAGE(p < 0.001). In the population with BMI ≥ 23, there were statistically significant differences in both MAGE levels and achievement rates among all the IR surrogate marker groups (all P < 0.05). (3) In the subgroup with BMI < 23, the multivariable logistic regression model revealed that, after adjusting for relevant confounding factors, a high TyG-BMI was a favourable factor for achieving the target MAGE(OR = 16.50, 95% CI 2.44-111.66). In the population with BMI ≥ 23, the multivariable logistic regression model indicated that high TyG (OR = 0.20,95% CI 0.09-0.46), TyG-BMI(OR = 0.27,95% CI:0.13-0.58), the metabolic score for IR (METS‒IR) (OR = 0.36,95% CI 0.17-0.77)and HOMA2-IR(OR = 0.01, 95% CI 0.00-0.02) values were adverse factors for achieving the target.</p><p><strong>Conclusion: </strong>In type 2 diabetic patients with BMI < 23, a high TyG-BMI was a favourable factor for achieving the target MAGE. For BMI ≥ 23, TyG, TyG-BMI, METS-IR and HOMA2-IR were adverse factors for achieving the target MAGE.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiplatelet therapy is associated with reduced mortality in patients with bloodstream infection: a propensity score-matched cohort study.","authors":"Sijing Sun, Mengxi Ding, Bin Yan, Lipo Song, Guojie Teng, Xueyuan Yu, Yachan Ning, Chunmei Wang","doi":"10.1186/s40001-026-04103-7","DOIUrl":"https://doi.org/10.1186/s40001-026-04103-7","url":null,"abstract":"<p><strong>Background: </strong>Bloodstream infection (BSI) is associated with a high mortality, ranging from 17 to 32%. Once pathogens enter the bloodstream, they can activate platelets and trigger systemic inflammation. Antiplatelet agents suppress platelet activation and modulate inflammatory responses; however, it remains unclear whether their use reduces mortality in patients with BSI. This study aimed to evaluate the impact of antiplatelet therapy on clinical outcomes in patients with BSI.</p><p><strong>Methods: </strong>We retrospectively analyzed patients diagnosed with BSI at Xuanwu Hospital, Capital Medical University, between 2013 and 2023. Patients were categorized into antiplatelet and non-antiplatelet groups. Propensity score matching was performed to minimize potential confounders, including age, sex, body mass index, year of onset, Charlson Comorbidity Index, and anticoagulant therapy. For the primary outcome (30-day all-cause mortality), group differences were analyzed using the logistic regression models, with results reported as odds ratios and 95% confidence intervals. Secondary endpoints, including respiratory failure, septic shock, acute kidney injury, and bleeding events, were similarly compared using the logistic regression. Subgroup analyses were performed according to causative pathogens and types of antiplatelet agents, with covariates showing standardized mean differences >0.1 included in the models.</p><p><strong>Main results: </strong>After Propensity score matching, a total of 248 patients were included in the analysis, with 124 patients in each group). The 30-day all-cause mortality following BSI diagnosis was significantly lower in the antiplatelet group (OR 0.35; 95% CI 0.17-0.71, P = 0.004). Septic shock, respiratory failure, acute kidney injury, and bleeding events showed no significant differences between groups (OR 1.08; 95% CI 0.50-2.34; P = 0.843, OR 0.72; 95% CI 0.33-1.60; P = 0.424, OR 1.20; 95% CI 0.31-2.33; P = 0.608, OR 0.71; 95% CI 0.55-2.37; P = 0.712). Subgroup analyses revealed that antiplatelet therapy significantly reduced mortality in patients with Gram-negative BSI (OR 0.26; 95% CI 0.08-0.87; P = 0.029). In addition, clopidogrel monotherapy was associated with lower mortality (OR 0.17; 95% CI 0.03-0.90; P = 0.017).</p><p><strong>Conclusions: </strong>In patients with BSI, antiplatelet therapy significantly reduced 30-day all-cause mortality without an increasing risk of bleeding.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional T2-weighted fast field echo imaging in the determination of the relationship between the intraparotid facial nerve and parotid tumors.","authors":"Yihua Wang, Haowen Zheng, Jian Jiang, Liangjie Lin, Haitao Huang, Juntao Ma, Qingwei Song, Lijun Wang, Ailian Liu","doi":"10.1186/s40001-026-04133-1","DOIUrl":"https://doi.org/10.1186/s40001-026-04133-1","url":null,"abstract":"<p><strong>Background: </strong>To assess the performance of three-dimensional T2-weighted fast field echo imaging (3D-T2-FFE) in the visualization of the intraparotid facial nerve (IFN) and localization of tumors.</p><p><strong>Methods: </strong>Magnetic resonance imaging data from sixty-four patients who underwent 3D-T2-FFE (Time of repetition 8.30 ms, Time of echo 4.10 ms, Voxel 0.65 × 0.65 × 1.00 mm, Field of view 220 × 220 × 65 mm, Matrix 340 × 339 × 130, Number of signal average 2, Flip angle 30°) were retrospectively enrolled. Finally, 64 cases of tumors were included (including 55 benign tumors and 9 malignant tumors). The identification certainty of IFN on 3D-T2-FFE was scored with an arbitrary scale of 0-3. The parotid gland was divided into superior and inferior parts, with the level of the earlobe (approximately at the level of the external auditory canal). The tumor location was categorized as deep or superficial directly on 3D-T2-FFE images and indirectly by the facial nerve line (FNL) and the retromandibular vein line (RMVL). Surgical localization was considered the reference standard. The accuracy, sensitivity, and specificity of each method for localizing parotid lesions were compared using the McNemar test.</p><p><strong>Results: </strong>The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for deep lobe lesions in the superior part of the parotid gland using the direct method were 97.8%, 92.3%, 100.0%, 100.0%, and 96.9%, respectively. The 3D-T2-FFE method showed significantly higher sensitivity and specificity than those of FNL (p < 0.05) in the superior part of the parotid gland, and there was no significant difference in sensitivity, specificity, and accuracy between 3D-T2-FFE and RMVL (p > 0.05). The relationship between the tumor and the main trunk of the IFN was correctly predicted in 93.3% and 100% of 3D-T2-FFE images in the superior and inferior parts of the parotid glands, respectively.</p><p><strong>Conclusions: </strong>3D-T2-FFE can provide detailed morphological information on the nerve in relation to adjacent parotid gland structures and tumors before surgery.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine and chemokine profile in rheumatoid arthritis patients with and without interstitial lung disease: a systematic review and meta-analysis integrating demographic, serological, and clinical comparisons.","authors":"Bing Xu, Xiliang Kao, Yuan Liu, Yuan Qu, Guangfeng Chen","doi":"10.1186/s40001-026-04074-9","DOIUrl":"https://doi.org/10.1186/s40001-026-04074-9","url":null,"abstract":"<p><p>Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a severe extra-articular complication of RA, contributing significantly to morbidity and mortality. Despite its impact, the immunological mechanisms driving RA-ILD remain poorly understood. This systematic review and meta-analysis aims to define a distinct immunological signature for RA-ILD and evaluate its associations with demographic, serological, and clinical parameters. Following PRISMA guidelines, we searched PubMed, Scopus, and Web of Science for studies comparing cytokine and chemokine levels in RA-ILD vs. RA patients without ILD. Eligible studies measured these molecules in biological samples and were published in English. Data were extracted on study characteristics, cytokine/chemokine levels, and clinical, serological, and demographic parameters. Meta-analyses used standardized mean differences for continuous outcomes and risk differences for dichotomous outcomes, with heterogeneity assessed via I2 and Cochran's Q tests. Narrative synthesis explored correlations due to heterogeneous reporting. From 2000 articles, 15 studies involving 3,433 patients (715 RA-ILD, 2,718 RA-no ILD) were included. RA-ILD patients exhibited elevated levels of six chemokines (CCL2, CCL4, CCL18, CXCL8, CXCL10, SDF-1α) and 11 cytokines (IL-1α, IL-4, IL-6, IL-11, IL-13, IL-18, IL-23, IL-33, IL-36α, IL-36γ, TGF-β), with reduced IL-22, forming a distinct immunological profile. RA-ILD patients had elevated anti-CCP, CRP, and RF levels, indicating heightened autoimmunity and greater disease activity. Correlations linked IL-13 and TGF-β to disease severity, while IL-22 and IL-36γ showed protective roles. This meta-analysis establishes a pioneering cytokine and chemokine profile distinguishing RA-ILD from RA, offering potential for early diagnosis and monitoring. Complementary demographic, serological, and clinical findings underscore RA-ILD's distinct pathogenesis.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of sitagliptin on blood pressure in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials.","authors":"Liying Peng, Wei Liu, Wei Feng, Gengbao Qu, Feng Wang","doi":"10.1186/s40001-026-04138-w","DOIUrl":"https://doi.org/10.1186/s40001-026-04138-w","url":null,"abstract":"<p><strong>Background: </strong>Sitagliptin, a dipeptidyl peptidase-4 inhibitors (DPP-4i), was commonly used as the hypoglycaemic agent, while the impact on blood pressure (BP) in type 2 diabetes mellitus (T2DM) remained unknown. The present study aimed to evaluate the effects of sitagliptin therapy on modulating systolic BP (SBP) and diastolic BP (DBP) in T2DM.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, and the Cochrane Library was conducted for randomized controlled trials (RCTs) examining the impact of sitagliptin on SBP and DBP in T2DM. Given to the inherent clinical heterogeneity, a random-effect model was used for the overall meta-analysis. Publication bias and sensitivity analysis were conducted using standard methods.</p><p><strong>Results: </strong>A total of 24 studies were identified. Treatment with sitagliptin was associated with a reduction in SBP (WMD = - 2.57 mmHg, 95% CI - 4.40 to - 0.75; I² = 0%; P = 0.006) and DBP (WMD = - 1.09 mmHg, 95% CI - 2.16 to - 0.03; I² = 0%; P = 0.04) compared to placebo in patients with T2DM. Exploratory subgroup analysis suggested a potential trend toward BP reduction according to the subgroup analysis on treatment duration, BMI, HbA1c and dosage. The leave-one-out sensitivity analysis supported the robustness of these pooled effects. No significant publication bias was observed in BP parameters across the RCTs according to Begg's and Egger's tests.</p><p><strong>Conclusions: </strong>Administration of sitagliptin was associated with a reduction of BP in patients with T2DM. However, its clinical role remained primarily glycemic control. The potential reduction of BP might be considered an ancillary benefit rather than a substitute for standard antihypertensive therapy. International prospective register for systematic review (PROSPERO) number: CRD42026128657.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the expression changes and clinical significance of ICAM-1, MMP-9, and Gal-3 in patients with ischemic stroke.","authors":"Yinyan Su, Jirong Li","doi":"10.1186/s40001-026-04069-6","DOIUrl":"https://doi.org/10.1186/s40001-026-04069-6","url":null,"abstract":"<p><strong>Background: </strong>To explore the relationship between serum intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), galectin-3 (Gal-3) and ischemic stroke, cerebral infarct volume, and neurological symptoms, and to evaluate their combined predictive value for poor prognosis.</p><p><strong>Methods: </strong>This observational case-control study enrolled 126 patients with cerebral infarction who were divided into small volume group, medium volume group, and large volume group based on infarct volume. Patients were also categorized into mild, moderate, and severe groups according to neurological deficit severity. In addition, 46 healthy subjects were recruited as the control group. Serum levels of ICAM-1, MMP-9, and Gal-3 were measured using enzyme-linked immunosorbent assay. Statistical analysis was performed using one-way ANOVA with post-hoc comparison testing, and ROC curve analysis was conducted to determine sensitivity and specificity.</p><p><strong>Results: </strong>Compared with the control group, serum ICAM-1, MMP-9, and Gal-3 levels increased significantly with increasing cerebral infarction volume in patients with cerebral infarction. Compared with the control group, serum ICAM-1, MMP-9, and Gal-3 levels increased significantly with increased neurological deficit in patients with cerebral infarction. Serum ICAM-1, MMP-9, and Gal-3 were significantly positively correlated with the volume of cerebral infarction and degree of neurological deficit for ischemic stroke. The AUC values for serum ICAM-1, MMP-9, and Gal-3 independently and in combination when predicting poor prognosis of patients with ischemic stroke were 0.805, 0.809, 0.815, and 0.917, respectively, with sensitivities of 80.23%, 81.50%, 78.26%, and 90.33%, respectively, and specificities of 75.26%, 70.10%, 76.20%, and 78.47%, respectively. The relevant cutoff values for these biomarkers were displayed to enable clinical application. The clinical value of these three indicators in combined detection showed a higher predictive performance than individual marker detection when predicting the poor prognosis of ischemic stroke.</p><p><strong>Conclusions: </strong>Serum ICAM-1, MMP-9, and Gal-3, which are all closely associated with cerebral infarction volumes and neurological deficit, appear to be very promising markers in patients with ischemic stroke. By documenting and exploring the dynamic changes of these three biomarkers in patients with stroke, we could not only enhance our understanding of the pathophysiological mechanism of ischemic stroke but also provide another scientific basis for early diagnosis, disease monitoring, and prognostic evaluations.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}