European Journal of Medical Research最新文献

{"title":"Adjuvant PD-1 inhibitors improve recurrence and survival outcomes in high-risk hepatocellular carcinoma patients after curative hepatectomy.","authors":"Xuehan Shen, Wei Yan, Erlei Zhang, Zhiwei Zhang, Zunyi Zhang, Hanhua Dong","doi":"10.1186/s40001-025-02444-3","DOIUrl":"10.1186/s40001-025-02444-3","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is the most prevalent malignancy in China, with liver resection recognized as the primary curative intervention. However, HCC patients face an elevated risk of recurrence, thereby significantly impacting prognosis.</p><p><strong>Purpose: </strong>This study aimed to assess the impact of adjuvant programmed cell death protein-1 (PD-1) inhibitors on survival outcomes in patients with HCC who are at high risk for postoperative recurrence following curative hepatectomy.</p><p><strong>Materials and methods: </strong>Among the 199 study participants, 77 received adjuvant PD-1 inhibitors. Propensity score matching (PSM) was used to balance baseline differences between patients who received adjuvant PD-1 inhibitors and those who did not. Assessment of overall survival (OS) and recurrence-free survival (RFS) was conducted using Kaplan-Meier curves, while Cox regression analysis was employed to identify prognostic factors influencing survival.</p><p><strong>Results: </strong>After PSM, the 1-year and 2-year RFS were 87.1% and 74.2% in the PD-1 inhibitors group and 44.6% and 37.8% in non-PD-1 inhibitors group (p < 0.001). The 1-year and 2-year OS were 98.5% and 95.7% in the PD-1 inhibitors group compared with 90.7% and 77.0% in non-PD-1 inhibitors group (p = 0.004). Multivariable analyses demonstrated that the use of adjuvant PD-1 inhibitors was significantly associated with improved RFS and OS. Subgroup analysis indicated that adjuvant PD-1 inhibitors group achieved longer RFS than the non-PD-1 inhibitors group in patients without adjuvant transarterial chemoembolization (TACE).</p><p><strong>Conclusion: </strong>The administration of adjuvant PD-1 inhibitors may effectively reduce the risk of tumor recurrence and improve survival in HCC patients with high risk of recurrence after curative hepatectomy.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"196"},"PeriodicalIF":2.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of one-stitch method of temporary ileostomy on the surgical outcomes and complications after laparoscopic low anterior resection in rectal cancer patients: a propensity score matching analysis.","authors":"Xin-Peng Shu, Jia-Liang Wang, Zi-Wei Li, Fei Liu, Xu-Rui Liu, Lian-Shuo Li, Yue Tong, Xiao-Yu Liu, Chun-Yi Wang, Yong Cheng, Dong Peng","doi":"10.1186/s40001-025-02464-z","DOIUrl":"10.1186/s40001-025-02464-z","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this current study was to explore whether one-stitch method (OM) of temporary ileostomy influenced the surgical outcomes after laparoscopic low anterior resection (LLAR).</p><p><strong>Methods: </strong>We retrospectively identified rectal cancer (RC) patients who underwent LLAR plus temporary ileostomy in a single teaching hospital from Jan 2011 to June 2023. According to the different methods of ileostomy, the patients were divided into the OM group and the traditional method (TM) group. A propensity score matching (PSM) analysis was performed to eliminate bias and compare the surgical outcomes.</p><p><strong>Results: </strong>A total of 469 RC patients were included in this study. There were 57 patients in the OM group and 412 patients in the TM group. After 1:1 PSM, there were 57 patients in each group, and no significant difference was found in baseline information (P > 0.05). In terms of surgical outcomes of primary RC surgery, we found that patients in the OM group had shorter operation time (P < 0.01), less blood loss (P < 0.01), and shorter postoperative hospital stay (P < 0.01) than in the TM group after PSM. Moreover, there was no significant difference in both overall complications and stoma-related complications. As for the outcomes of stoma reversal surgery, patients in the OM group had shorter postoperative hospital stay (P = 0.002) than in the TM group before PSM. However, no significant difference was found after PSM (P > 0.05).</p><p><strong>Conclusion: </strong>The OM of temporary ileostomy was easier, more effective and time-saving than the TM, which did not increase the incidence of both postoperative complications and stoma-related complications.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"197"},"PeriodicalIF":2.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis.","authors":"DongMei Tang, XiaoXuan Cao, BeiBei Yuan, HongXing Zou, MingDe Huang, WeiFeng Shen","doi":"10.1186/s40001-025-02434-5","DOIUrl":"10.1186/s40001-025-02434-5","url":null,"abstract":"<p><strong>Objective: </strong>This study explored the correlation between interleukin-1 receptor/Toll-like receptor (IL-1R/TLRs)-mediated inflammatory signaling pathways and the severity of superficial dermatomycosis.</p><p><strong>Methods: </strong>From May 2020 to August 2022, 76 patients with superficial dermatomycosis (infected group) and 52 patients without infection (non-infected group) were enrolled. The indicators related to IL-1R/TLRs pathway were analyzed, and the diagnostic value of the combined detection of each index for superficial dermatomycosis and disease severity was analyzed. The correlation between each index and the severity of infection was analyzed.</p><p><strong>Results: </strong>IL-1β, TLR4, IL-6, and TNF-α in the infected group were higher than those in the non-infected group (P < 0.05). The AUC of IL-1R/TLRs combined detection in the group diagnosed with a superficial dermatomycosis was higher than that of each single detection (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α in the severe group were higher than those in the mild group (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α were positively correlated with the degree of infection (P < 0.05). The AUC of IL-1R/TLRs combined detection was higher than that of each single test (P < 0.05). IL-1β ≥ 2.87 ng/L, TLR4 ≥ 3.12 ng/L, IL-6 ≥ 4.58 ng/L, TNF-α ≥ 70.53 ng/L were the influencing factors of severe superficial dermatomycosis (P < 0.05).</p><p><strong>Conclusion: </strong>IL-1R/TLRs pathway is related to the severity of superficial dermatomycosis, and the collective identification of each indicator provides diagnostic insight into infection severity.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"191"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dyslipidemia with intervertebral disc degeneration: a case-control study.","authors":"Bing Tan, Shanlin Xiang, Yuhao Zheng, Jianyuan Ouyang, Nian Zhou","doi":"10.1186/s40001-025-02455-0","DOIUrl":"10.1186/s40001-025-02455-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between dyslipidemia and intervertebral disc degeneration (IVDD).</p><p><strong>Methods: </strong>A total of 269 patients with lumbar disc herniation (Grade III-VIII using the modified Pfirrmann Grading Systems and Total End Plate Damage Score (TEPS) III-VI grade) and 269 patients with lumbar vertebral fracture (LVF, Grade I-II using the modified Pfirrmann Grading Systems and TEPS I-II grade) were enrolled in this study. The total cholesterol level (TC), low-density lipoprotein-cholesterol level (LDL-C), triglyceride level (TG), high-density lipoprotein-cholesterol level (HDL-C), nonHDL-C, ApoB level, ApoB A1 level and arteriosclerosis index (AI) were measured. The 269 patients with single-level LDH who underwent surgery were assigned to the disc herniation group (DH) and 269 patients who underwent surgical treatment for lumbar vertebral fracture during the same period were enrolled as the control group. The participants in the control group were selected randomly and matched for sex.</p><p><strong>Results: </strong>The analysis revealed that the levels of TC, TG, LDL, nonHDL-C, APOB, and APOA1 in patients with LDH were significantly higher compared with those in the controls. The proportion of high-TC, borderline high-total cholesterol, high LDL-C, high-TG, borderline high LDL-C, high APO B, high arteriosclerosis index (AI), and high-ApoB/ApoA1 in the LDH group was significantly higher relative to that of the control group. The ratio of TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, nonHDL-C/HDL-C, and ApoB/ApoA1 in the LDH group was significantly higher compared with that of the control group. Multivariate logistic regression analysis showed that the levels of serum TG, Apo B/ApoA1 ratio, atherogenic index(AI), labour intensity, and age were positively associated with the risk of LDH and were independent risk factors predicting IVDD development.</p><p><strong>Conclusion: </strong>Overall, this study indicates that age, labour intensity, TG, ApoB/ApoA1 ratio and atherogenic index (AI) may increase the risk of IVDD. The levels of TC, TG, LDL-C, nonHDL-C, Apo B, and atherogenic index (AI) may be related to the degree of cartilage endplate (CEP) and intervertebral disc degeneration (IVDD). Moreover, dyslipidemia may be a useful predictor of IVDD.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"194"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Napkin-ring sign plaques are associated with cerebral small vessel disease.","authors":"Hui Zhou, Qiao Lin, Xinwei He, Rui Huang, Linkao Chen","doi":"10.1186/s40001-025-02371-3","DOIUrl":"10.1186/s40001-025-02371-3","url":null,"abstract":"<p><strong>Background: </strong>Few studies have investigated the association between the carotid artery napkin-ring sign (NRS) and cerebral small vessel disease (CSVD). This study aimed to investigate whether carotid NRS plaque burden and CSVD are associated.</p><p><strong>Methods: </strong>This retrospective, single-center, cross-sectional study following STROBE guidelines enrolled patients with symptoms or clinical suspicion of anterior circulation acute ischemic stroke (AIS). Plaques were evaluated using preoperative cervicocerebral computed tomography angiography (CTA). Imaging markers of CSVD, such as white matter hyperintensities (WMHs) and perivascular spaces (PVSs), were assessed.</p><p><strong>Results: </strong>A total of 575 patients (64.9 ± 8.0 years, 378 men) were evaluated. Patients with AIS had a higher percentage of total NRS plaques than those in the control group (144 (37.1%) vs. 45 (24.1%), P = 0.002), and the total NRS amount increased the risk of AIS after adjusting for confounding factors (odds ratio 1.717; 95%CI 1.141-2.584; P = 0.009). A higher WMHs grade was associated with the presence of NRS plaques (P < 0.001) and a higher total NRS area (P < 0.001). A higher PVSs grade was associated with positive remodeling (PR) on the NRS (P = 0.006).</p><p><strong>Conclusions: </strong>An increased incidence of NRS plaques on CTA was associated with the occurrence of AIS, and the area and PR of NRS plaques were associated with the risk stratification of CSVD.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"190"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ship-shaped resection with nail matrix destruction: an improved and aesthetical surgical approach for grade II/III ingrown toenails.","authors":"Liang Chen, Dong Dong, Heng Wang, Wei Wang, Yiqun Zhou, Yu Guo, Jingjing Zhu, Tianyi Liu","doi":"10.1186/s40001-025-02463-0","DOIUrl":"10.1186/s40001-025-02463-0","url":null,"abstract":"<p><strong>Background: </strong>Ingrown nails may cause progressively aggravated pain, discomfort and immobility. We modified the traditional Winograd procedure and proposed an improved surgical method which is ship-shaped resection along with nail matrix destruction. We evaluate the clinical outcome of this improved approach, especially in terms of recurrence and healing time as well as the aesthetical outcomes.</p><p><strong>Methods: </strong>We retrospectively analyzed the outcomes of 200 consecutive patients with grade II/III ingrown toenails were operated using this method from November 2020 to November 2022. Follow-up data were obtained from routine outpatient clinic controls at postoperative days 1, 14, 30 and 90, as well as a follow-up phone call 1 year after the surgery.</p><p><strong>Results: </strong>The average operation time was 30 min (range 20-33). There was no important complication except some bleeding. All of these cases were managed well with a complete recovery. The healing time was 12.5 days (range: 10-18). In addition, patients returned to their daily activities in approximately 5 days. Besides, 165 (82.5%) were very satisfied, 35 (17.5%) were satisfied, no patients were dissatisfied. Besides, the recurrence rate was 1% (2 patients) and postoperative local infection was observed in 3 patients (1.5%). 193 (96.5%) patients reflected the appearance after surgery was esthetic, 7(3.5%) patients for moderate and no patients for unesthetic.</p><p><strong>Conclusions: </strong>Thus, we can conclude that this improved surgical procedure is a promising method to treat grade II/III ingrown toenail with less scarring, aesthetic appearance, low recurrence rate, rapid healing, and high patient satisfaction.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"192"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term follow-up of the effect of oral dienogest and dienogest/ethinylestradiol treatment on cell-free DNA levels in patients with deep endometriosis.","authors":"P Carrillo Torres, D Tàssies, H Castillo, M Gracia, G Feixas, J C Reverter, F Carmona, M A Martínez-Zamora","doi":"10.1186/s40001-025-02429-2","DOIUrl":"10.1186/s40001-025-02429-2","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis is currently considered a systemic inflammatory disease and different non-invasive inflammatory markers, such as cell-free DNA (cfDNA), have recently been evaluated. Hormonal treatments are frequently prescribed as first-line treatments to improve symptoms, reduce lesions and improve the quality of life of patients with endometriosis. The most frequently used hormonal treatments are estroprogestins and progestins due to their effectiveness and well-tolerated clinical profile. However, the impact these hormonal treatments may have on these markers has yet to be determined. The aim of this study was to assess whether cfDNA levels are modified under the two main first-line hormonal treatments in patients with deep endometriosis (DE).</p><p><strong>Methods: </strong>Ninety patients diagnosed with DE were analyzed in this prospective, observational study. Forty-five received daily oral treatment with dienogest 2 mg, and 45 with 2 mg dienogest/30 μg ethinylestradiol. Plasma cfDNA levels were evaluated by fluorescent assay prior to initiation of treatment and at 6 and 12 months of treatment.</p><p><strong>Results: </strong>An increase in cfDNA levels was observed during the follow-up at 6 and 12 months. However, these higher levels were only statistically significant at 12 months of treatment. The increase of cfDNA levels was similar with both treatments.</p><p><strong>Conclusion: </strong>Higher cfDNA levels were observed in DE patients at 12 months of oral hormonal treatment showing similar results with dienogest or dienogest/ethinylestradiol. This increase could be explained by apoptosis of the endometriosis foci due to the treatment.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"193"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway.","authors":"Cunju Bo, Xiaoming Liu, Yongjian Liu, Lingjun Xu, Qiaodong Huang","doi":"10.1186/s40001-025-02424-7","DOIUrl":"10.1186/s40001-025-02424-7","url":null,"abstract":"<p><strong>Background: </strong>Neuropathic pain is characterized by hyperalgesia, allodynia, and inflammation and it is often resistant to treatment. The formyl peptide receptor 2 (ALX/FPR2), a G-protein-coupled receptor, has been implicated in resolving inflammation, making its agonist, Resolvin D1 (RvD1), a potential therapeutic agent. Previous studies suggest that RvD1 alleviates neuropathic pain via anti-inflammatory effects, but its mechanisms remain unclear, particularly in relation to microglial activation and the brain-derived neurotrophic factor (BDNF)/TrkB signaling pathway.</p><p><strong>Objective: </strong>To investigate the analgesic effects of RvD1 in a spared nerve injury (SNI) model of neuropathic pain and explore its mechanisms through the regulation of neuroinflammation and the BDNF/TrkB signaling pathway.</p><p><strong>Methods: </strong>SNI mice received intrathecal RvD1 at varying doses (10-40 ng) to determine its efficacy in reducing mechanical allodynia and thermal sensitivity. The anti-inflammatory effects of RvD1 were assessed using ELISA, immunofluorescence, and western blotting to measure the expression of pro-inflammatory cytokines and BDNF. The involvement of ALX/FPR2 and TrkB receptors was further examined using antagonists Boc2 and K252a.</p><p><strong>Results: </strong>RvD1 significantly reduced mechanical and thermal allodynia in SNI mice in a dose-dependent manner. RvD1 also decreased microglial activation and expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and BDNF in both in vivo and in vitro models. These effects were reversed by Boc2 and K252a, confirming that the analgesic actions of RvD1 are mediated via the ALX/FPR2 receptor and inhibition of BDNF/TrkB signaling.</p><p><strong>Conclusion: </strong>RvD1 alleviates neuropathic pain by reducing neuroinflammation through the ALX/FPR2 receptor and suppressing BDNF/TrkB signaling. These findings suggest RvD1 as a promising therapeutic agent for neuropathic pain management.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"189"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of a prediction model for acute kidney injury in moderate severe and severe acute pancreatitis patients.","authors":"Wen-Jie Chen, Qin-Yue Su, Ming Zhong, Yan-Jun Zheng, Xiao-Feng Wang, Hong-Ping Qu, En-Qiang Mao, Zhi-Tao Yang, Er-Zhen Chen, Ying Chen","doi":"10.1186/s40001-025-02394-w","DOIUrl":"10.1186/s40001-025-02394-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a nomogram for predicting acute kidney injury (AKI) in patients with moderate severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP).</p><p><strong>Methods: </strong>This study enrolled a total of 1,077 patients with MSAP and SAP, categorizing them into three groups: training (n = 646), internal validation (n = 278), and external validation (n = 153). In the training cohort, logistic regression analysis identified independent predictors of AKI in patients with MSAP and SAP. A nomogram was developed based on these independent predictors. The model's performance was assessed using the receiver operating characteristics (ROC) curve, precision-recall (PR) curve, calibration curve, and decision curve analysis (DCA).</p><p><strong>Results: </strong>The incidence rates of AKI in the training set, internal validation set, and external validation set were 32.82%, 32.01%, and 27.45%, respectively. Independent predictors of AKI in patients with MSAP and SAP included: shock index (odds ratio [OR] = 7.42, 95% confidence interval [CI] 2.18-25.19), blood urea nitrogen (OR = 1.32, 95% CI 1.22-1.43), uric acid (OR = 1.002, 95% CI 1.000-1.003), serum calcium (OR = 0.38, 95% CI 0.18-0.79), triglycerides (OR = 1.02, 95% CI 1.004-1.041), hematocrit > 0.5 (OR = 3.24, 95% CI 1.10-9.59), serum sodium < 135 mmol/L (OR = 2.01, 95% CI 1.15-3.49), creatine kinase isoenzyme > 4 ng/mL (OR = 2.61, 95% CI 1.48-4.61), and thrombin time < 14 s (OR = 2.83, 95% CI 1.28-6.27). In the training, internal validation, and external validation sets, the areas under the ROC curves for the nomogram were 0.841, 0.789, and 0.853, respectively. Similarly, the areas under the PR curves were 0.807, 0.733, and 0.770. The calibration curves demonstrated that the predicted outcomes were well-aligned with the actual results. The decision curve analysis (DCA) indicated that the model had satisfactory clinical applicability.</p><p><strong>Conclusions: </strong>Nine indicators have been identified as independent predictors of AKI in patients with MSAP and SAP. The developed nomogram exhibits robust predictive capability and shows promise for clinical application.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"187"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparisons of three novel markers for insulin resistance to predict incident cardiovascular disease: a Korean cohort study from three different regions.","authors":"Ha Eun Ryu, Yong Jae Lee, Byoungjin Park, Dong Hyuk Jung","doi":"10.1186/s40001-025-02374-0","DOIUrl":"10.1186/s40001-025-02374-0","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is a crucial human health challenge. Previous studies have shown an association between CVD and the triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), and metabolic score for insulin resistance (METS-IR). However, a comparison of these novel markers for predicting CVD is not well known. Therefore, we aimed to assess the value of TyG, AIP, and METS-IR in predicting the incidence of CVD in three large cohorts of Korean adults.</p><p><strong>Methods: </strong>Data from 28 437 participants in the Korean Genome and Epidemiology Study (KoGES) and Korea Health Insurance Review and Assessment (HERAS-HIRA) were assessed. The participants were divided into four groups according to the quartiles of TyG index: ln ([triglyceride × fasting plasma glucose]/2), AIP calculated as log (triglyceride/high-density lipoprotein cholesterol), and METS-IR index: (ln ([2 × fasting plasma glucose] + triglyceride) × body mass index)/(ln [high-density lipoprotein cholesterol-cholesterol]). We prospectively assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for CVD using multivariate Cox proportional hazard regression models after adjusting for potential confounding variables.</p><p><strong>Results: </strong>During the follow-up period, 987 participants (3.5%) developed CVD. Compared with the referent first quartiles, the highest TyG index, AIP, and METS-IR quartiles, with HRs of 1.73 (95% CI 1.41-2.12), 1.47 (95% CI 1.19-1.80), and 2.61 (95% CI 1.83-3.72), respectively, significantly predicted future CVD, after adjusting for age, sex, and body mass index. When comparing the three biomarkers for insulin resistance, the TyG index and METS-IR showed similar predictive values, whereas AIP had a lower significance in predicting CVD.</p><p><strong>Conclusions: </strong>Based on the current findings, novel surrogate markers of insulin resistance, particularly METS-IR and TyG index, may help predict the risk of CVD in Koreans.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"188"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}