European Journal of Integrative Medicine最新文献

{"title":"Comparative efficacy of health Qigong and yoga on fatigue, sleep disturbance, depression and quality of life in patients with breast cancer: A systematic review and network meta-analysis","authors":"Zhengjia Li,&nbsp;Jun Zhao,&nbsp;Xincheng Duan,&nbsp;Keyu Han,&nbsp;Xiaomin Chang,&nbsp;Xi Chen,&nbsp;Wenxiao Zhao","doi":"10.1016/j.eujim.2025.102526","DOIUrl":"10.1016/j.eujim.2025.102526","url":null,"abstract":"<div><h3>Introduction</h3><div>Both health Qigong, a practice rooted in traditional Chinese medicine, and yoga have demonstrated effectiveness in alleviating symptoms of fatigue, sleep disturbance, and depression while enhancing the quality of life in patients with breast cancer. However, it remains unclear which specific form of health Qigong or yoga is the most effective. This study aimed to compare the efficacy of various forms of health Qigong and yoga on fatigue, sleep disturbance, and depression and quality of life in patients with breast cancer.</div></div><div><h3>Methods</h3><div>Ten databases were searched to identify relevant studies from inception to May 21, 2025. A distribution Bayesian network meta-analysis with non-informative prior was conducted using R 4.4.0 software. Studies that met the eligibility criteria were assessed for risk of bias and certainty of evidence.</div></div><div><h3>Results</h3><div>The network meta-analysis included 34 eligible studies with 2344 participants with breast cancer across five exercise modalities. For improving cancer-related fatigue, Tai Chi demonstrated the highest surface under the cumulative ranking area (SUCRA) value at 0.76; for sleep quality improvement, Baduanjin scored the highest at 0.97; Liu- Zi Jue ranked highest at 0.90 for alleviating depression; and Tai Chi also led with a SUCRA value of 0.67 for enhancing quality of life.</div></div><div><h3>Conclusions</h3><div>This study suggested that Tai Chi is the most effective for improving cancer-related fatigue and quality of life, while Baduanjin is optimal for enhancing sleep quality. Liu Zi Jue is best suited for alleviating depression, highlighting Tai Chi as a comprehensive exercise option.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102526"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety investigation of LIMAN technology based curcumin formulation on knee osteoarthritis: a randomized double-blind placebo-controlled trial","authors":"Girish HR ,&nbsp;Harshith N ,&nbsp;Nehru Sai Suresh Chalichem ,&nbsp;Abhijith Phanindra ,&nbsp;Mohammed S. Khan ,&nbsp;Jayant Deshpande","doi":"10.1016/j.eujim.2025.102531","DOIUrl":"10.1016/j.eujim.2025.102531","url":null,"abstract":"<div><h3>Introduction</h3><div>Knee osteoarthritis is the most common and extensively studied form of osteoarthritis, with varying prevalence reported across studies. Although the presentation of knee osteoarthritis can differ among individuals, it typically manifests as joint pain, stiffness, and restricted mobility, often accompanied by muscle weakness and balance issues. The present clinical study aimed to evaluate the safety and efficacy of Maxicuma®, a highly bioavailable form of curcumin, made from ethanolic extract of turmeric, at two different doses in reducing the symptoms and improving the functional status in individuals with knee osteoarthritis.</div></div><div><h3>Methods</h3><div>A total of 180 subjects with knee osteoarthritis as per NICE criteria were recruited into the study and severity of either Grade II or Grade III was assessed by radiographic analysis as per Kellgren-Lawrence (KL) scale. Participants received a daily single dose of either placebo, Maxicuma 100 or Maxicuam 250 per day for 90 days. Efficacy was assessed using WOMAC (Western Ontario and McMaster Universities Arthritis Index), VAS (Visual analog scale) and treadmill walk test to understand severity, intensity of pain and physical performance respectively, at day 30, day 45, day 60 and day 90.</div></div><div><h3>Results</h3><div>The test item was well tolerated with no major adverse events reported. A total of 180 and 174 subjects were considered for intention-to-treat and per-protocol analysis, respectively. Both doses of Maxicuma® demonstrated statistical significance (<em>p</em> &lt; 0.05) compared to placebo starting from day 30 across all efficacy measures.</div></div><div><h3>Conclusion</h3><div>Findings from this clinical study indicate that Maxicuma® 100 mg and 250 mg are effective and well-tolerated supplement options for managing knee osteoarthritis. Both dosages showed potential in improving clinical symptoms and enhancing functional outcomes.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102531"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the potential of terminalisa ferdinandiana Exell (Kakadu Plum) in photoprotection through direct and indirect evidence: A scoping review","authors":"Gahena Ram ,&nbsp;Rotina Kapini ,&nbsp;Xian Zhou","doi":"10.1016/j.eujim.2025.102547","DOIUrl":"10.1016/j.eujim.2025.102547","url":null,"abstract":"<div><h3>Introduction</h3><div>Australia has some of the highest rates of sun-related skin damage in the world. Native Australian flora is known to possess unique phytochemical profiles with potential protective effects against such damage. The Kakadu Plum (<em>Terminalia ferdinandiana</em> Exell), traditionally utilized by Indigenous Australians, is notable for its exceptionally high concentrations of vitamin C and diverse phenolic compounds. This scoping review aims to synthesise the available evidence regarding the efficacy of Kakadu Plum as a topical intervention for the primary prevention of photodamage.</div></div><div><h3>Methods</h3><div>The methodology was guided by the JBI Manual for Evidence Synthesis, and the reporting was guided by the PRISMA Extension for Scoping Reviews. A comprehensive search was conducted across multiple databases, including MEDLINE, PubMed, Embase, Scopus, Google Scholar, and the Agriculture Science Database, to gather direct and indirect data on Kakadu Plum's photoprotective potential and vitamin C concentrations over the past 20 years (2005–2025).</div></div><div><h3>Results</h3><div>A total of 31 preclinical studies were found. Only 1 study directly examined Kakadu Plum's photoprotective effect in an animal model, 22 studies provided evidence of indirect photoprotective mechanisms, including antioxidant and anti-inflammatory effects, and 8 studies exclusively reported on the vitamin C content.</div></div><div><h3>Conclusion</h3><div>The results demonstrated exceptionally high vitamin C concentrations, providing strong indirect evidence of Kakadu Plum's potential photoprotective effect. However, the absence of direct experimental or clinical evidence precludes definitive conclusions regarding its efficacy. Kakadu Plum, therefore, may be an underexplored natural resource, warranting further research into its photoprotective mechanisms and therapeutic potential.</div></div><div><h3>Funding</h3><div>Dr. Xian Zhou is supported by the Research Support Fellowship, <span>Western Sydney University</span>.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102547"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic and cytotoxic activities of Onosma aucheriana extract: Molecular interactions and antioxidant potential","authors":"Metin Caliskan ,&nbsp;Sercin Ozlem Caliskan ,&nbsp;Emine Incilay Torunoglu ,&nbsp;Erdi Can Aytar ,&nbsp;Alper Durmaz","doi":"10.1016/j.eujim.2025.102549","DOIUrl":"10.1016/j.eujim.2025.102549","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigates the anticancer, photodynamic, antioxidant efficiency and molecular interaction profiles of <em>Onosma aucheriana</em> methanol extract.</div></div><div><h3>Method</h3><div>The cell viability of normal (HEK293) and gastric cancer (MKN28) cell lines was evaluated using IC₅₀ values, including photodynamic activity under green light. Antioxidant potential was assessed through DPPH radical scavenging, while phytochemical contents were quantified spectrophotometrically. Gas chromatography-mass spectrometry (GC–MS) analysis identified major compounds, and molecular docking studies explored their interactions with target proteins.</div></div><div><h3>Results</h3><div>Cell viability assays showed a dose-dependent reduction in cell viability, with IC₅₀ values of 1036 μg/mL for HEK293 and 951.8 μg/mL for MKN28. To assess photodynamic activity, green light was used, revealing IC₅₀ values of 56.62 μg/mL for normal cells and 32.53 μg/mL for cancer cells. A more pronounced reduction in cell viability was observed in cancer cells compared to normal cells. However, it demonstrates significant photodynamic activity at a concentration approximately 1/18th of the IC₅₀ value for normal cells and about 1/29th of the IC₅₀ value for cancer cells. The extract, with a DPPH radical scavenging IC₅₀ value of 154.15 ± 1.04 µg/mL, exhibits strong antioxidant activity, which is greater than that of BHT (230 ± 10 µg/mL). The total flavanol, flavonoid, phenolic, proanthocyanidin, and tannin contents are quantified as 24.30 ± 1.23 mg QE/g, 32.96 ± 3.23 mg QE/g, 6.31 ± 0.79 mg GAE/g, 83.41 ± 12.95 mg CAE/g, and 27.32 ± 2.30 mg GAE/g, respectively. GC–MS analysis reveals inositol (30.47 %), 4-((1E)‑hydroxy-1-propenyl)-2-methoxyphenol (23.04 %), 3-amino-2,6-dimethylpyridine (7.41 %), and 3-buten-2-one, 4-(4‑hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0] hept‑1-yl) (5.99 %) as major components. Molecular docking studies reveal that 3-buten-2-one, 4-(4‑hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0] hept‑1-yl) exhibits strong binding interactions with BAF complex (6LTJ), inositol shows substantial hydrogen bonding, and 4-((1E)‑hydroxy-1-propenyl)-2-methoxyphenol demonstrates significant binding with several receptors.</div></div><div><h3>Conclusion</h3><div>The <em>O. aucheriana</em> extract exhibited strong antioxidant activity and a novel photodynamic cytotoxic effect that became prominent under green light exposure. These findings suggest that the extract may possess versatile therapeutic potential.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102549"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preference and usage of herbal and orthodox medicines and dosage form preferences among adults visiting two hospitals in Ho, Ghana: a cross-sectional survey","authors":"Hilda Amekyeh ,&nbsp;Doris Kumadoh ,&nbsp;Salifu Nanga ,&nbsp;Donatus Wewura Adongo ,&nbsp;Gideon Krobea-Asante ,&nbsp;Barbara Owusu-Ansah ,&nbsp;Kwabena Larbi Awuku-Larbi ,&nbsp;Albert Ekow Mensah ,&nbsp;John Korbuvi ,&nbsp;Mike Okweesi Aggrey","doi":"10.1016/j.eujim.2025.102554","DOIUrl":"10.1016/j.eujim.2025.102554","url":null,"abstract":"<div><h3>Introduction</h3><div>The usage and preferences of treatments among patients must be understood to guide policy development and improve healthcare. Additionally, the dosage form in which a medicine is presented to a patient can influence compliance with therapy. Therefore, in this study, we investigated the preference of herbal medicine versus orthodox medicine, usage of the two medicine types, and desired oral and topical formulations among adults.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted among 430 respondents at the outpatient departments of Ho Municipal Hospital and Ho Teaching Hospital in the Ho municipality of Ghana. Participants were purposively sampled to complete a questionnaire, after which the data were analyzed.</div></div><div><h3>Results</h3><div>Participants mostly preferred orthodox medicine (78.8 %). Treatment preference was influenced by age (<em>p</em> = 0.033) and educational level (<em>p</em> = 0.013). Key reasons for preferring either treatment were perceived effectiveness (55.8 %, orthodox; 14.4 %, herbal) and safety (60.0 %, orthodox; 9.5 %, herbal). Unprescribed medicine usage (herbal/orthodox) was attributed to self-medication (11.6 %), radio/TV adverts (12.6 %), and non-professional advice (36.5 %). Tablets (54.9 %), capsules (54.0 %), and liquids (44.9 %) were the preferred oral formulations; younger and older participants largely preferred liquids and capsules, respectively. Educational level influenced capsule preference (<em>p</em> = 0.039). Income level showed significant associations with capsules (<em>p</em> &lt; 0.00001), liquids (<em>p</em> = 0.012), and powders (<em>p</em> &lt; 0.00001). Ointments (61.2 %), creams (56.3 %), and gels (25.3 %) were the preferred topical products, with preferences significantly affected by income, education, and religion.</div></div><div><h3>Conclusion</h3><div>Our findings indicate a higher preference for orthodox medicine over herbal medicine as well as preference for conventional oral and topical dosage forms. Indiscriminate medicine usage by some participants was also observed, indicating that control of medicine information in the media and enhanced public education on medicine safety are needed.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102554"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of East Asian herbal medicine for treating depression in older adults: A systematic review and meta-analysis","authors":"Sang-Ho Kim ,&nbsp;Ga-Young Jung","doi":"10.1016/j.eujim.2025.102528","DOIUrl":"10.1016/j.eujim.2025.102528","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional East Asian herbal medicine (EAHM) has been used for centuries to treat depression. This review aimed to analyze the effectiveness and safety of EAHM in older adults with depression.</div></div><div><h3>Methods</h3><div>Eleven electronic databases were searched on May 30, 2024, for randomized controlled trials (RCTs) of EAHM for depression in older adults. The Cochrane risk of bias tool assessed the studies’ quality. We evaluated the efficacy and safety of EAHM for depression in older adults through a meta-analysis.</div></div><div><h3>Results</h3><div>Twenty RCTs (1681 participants) were included. Pooled results suggested that the efficacy of EAHM alone was similar to antidepressants alone in terms of the Hamilton depression scale (HAMD) scores (standardized mean difference [SMD], -0.60; 95% confidence interval [CI], -1.72 to 0.52; <em>P</em> = 0.29). The combination of EAHM with either antidepressants alone or antidepressants plus antihypertensive drugs yielded a statistically significant improvement in HAMD scores (SMD = -2.50, 95% CI: -3.37 to -1.63, <em>P</em> &lt; 0.001) and total effective rate (TER) (RR = 1.20, 95% CI: 1.11–1.30; <em>P</em> &lt; 0.001). The risk of adverse events was lower with EAHM alone compared to antidepressants alone, while combination therapy showed a similar risk. The overall risk of bias was high, and the evidence level ranged from very low to moderate.</div></div><div><h3>Conclusion</h3><div>This study indicates that EAHM, as monotherapy or adjunctive therapy to antidepressants, may benefit depression in older adults. However, the meta-analysis results may be overestimated due to the limited number of studies, their low methodological quality, and clinical heterogeneity. Therefore, the evidence remains inconclusive, and further studies are warranted.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102528"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the intersection of heart rate variability and complementary medicine: a two-decade bibliometric study (2005–2024)","authors":"Shih-Wei Yang ,&nbsp;Chen-Wei Chang ,&nbsp;Malcolm Koo","doi":"10.1016/j.eujim.2025.102560","DOIUrl":"10.1016/j.eujim.2025.102560","url":null,"abstract":"<div><h3>Introduction</h3><div>Heart Rate Variability (HRV), a noninvasive marker of autonomic nervous system function, has become an increasingly utilized tool in complementary medicine (CM) research for objectively assessing physiological responses to interventions. While specific applications of HRV within individual CM modalities have been reviewed, comprehensive mapping of the broader research landscape remains limited. This bibliometric study aimed to provide a detailed overview of the evolution, key contributors, and thematic development of HRV research across diverse CM interventions between 2005 and 2024.</div></div><div><h3>Methods</h3><div>Original research articles published between January 1, 2005, and December 31, 2024, were retrieved from the Science Citation Index Expanded of the Web of Science Core Collection. A Boolean search strategy combined HRV-related terms with keywords representing a wide range of CM interventions, while deliberately excluding broad or ambiguous descriptors. The data were analyzed using the Bibliometrix package.</div></div><div><h3>Results</h3><div>A total of 1007 articles published across 375 journals and authored by 4969 individuals were identified, with publication output showing a steady increase and peaking in 2022. China (23.5%) and the United States (19.1%) emerged as the most prolific contributors, although United States publications exhibited a higher average citation rate. Leading institutions included Kyung Hee University (South Korea) and China Medical University (Taiwan). <em>Evidence-Based Complementary and Alternative Medicine</em> was the most frequent publishing journal. HRV and CM research has increasingly appeared in higher-ranked journals over time (<em>p</em> &lt; 0.001). Keyword co-occurrence analysis positioned HRV as a central term, connecting clusters related to mind-body practices, psychophysiological constructs, music therapy, and electroacupuncture. Thematic evolution analysis revealed recent trends toward greater methodological rigor, increased emphasis on patient-centered outcomes, diversification of CM interventions, and incorporation of emerging digital health technologies.</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis shows HRV research in CM as an evolving field positioned at the intersection of traditional practices, contemporary physiological science, and technological innovation. Recent trends indicate a shift toward increased methodological rigor, greater emphasis on patient-centered outcomes, and integration of digital technologies. As the field advances, novel technologies such as generative artificial intelligence offer promise for deepening physiological insights and enhancing the clinical relevance of CM applications within mainstream healthcare.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102560"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Piper longum L. for acute respiratory infections: A systematic review","authors":"Anugraha George ,&nbsp;Prakash Bangalore Nagendrappa ,&nbsp;Unnikrishnana Payyappallimana ,&nbsp;Xiao-Yang Hu ,&nbsp;Xiaowen Zhang ,&nbsp;Sadia Wali ,&nbsp;Merlin Willcox","doi":"10.1016/j.eujim.2025.102559","DOIUrl":"10.1016/j.eujim.2025.102559","url":null,"abstract":"<div><h3>Introduction</h3><div>Antimicrobial resistance (AMR) is a serious threat to global public health by compromising the effectiveness of infection prevention and treatment strategies. This escalating issue necessitates the exploration of alternative treatments and natural remedies to reduce reliance on antibiotics. <em>Piper longum</em> L. has historically been used in the treatment of respiratory infections in Ayurvedic medicine. This systematic review aims to evaluate the safety and efficacy of <em>Piper longum</em> in managing Acute Respiratory Infections (ARIs).</div></div><div><h3>Methods</h3><div>Nine databases (PubMed, Embase, Cochrane CENTRAL, CINAHL, AMED, ProQuest, CNKI, and Google Scholar) were systematically searched for randomized controlled trials (RCTs) and non-randomized controlled clinical trials (NRCTs) evaluating <em>Piper longum</em>. The primary outcomes assessed were improvement in acute respiratory infections, ARI symptoms and side effects. A narrative approach was used to synthesize the data. The Cochrane Risk of Bias tool was used to assess study quality, and Rayyan was used to screen eligible studies. Data extraction was performed independently by two reviewers.</div></div><div><h3>Results</h3><div>Two studies met the inclusion criteria (one RCT and one NRCT). One study reported that <em>Piper longum</em> improved symptoms of acute respiratory infections (ARIs), including frequency of cough bouts, sleep disturbances, sputum production, crepitations, throat infections, wheezing, nasal discharge, and loss of appetite. Side effects associated with <em>Piper longum</em> ranged from minimal (such as chest burning) to none. However, the methodological quality of the included trials was generally poor.</div></div><div><h3>Conclusion</h3><div><em>Piper longum</em> may be beneficial and safe for relieving symptoms of ARIs. Nevertheless, these findings should be interpreted with caution due to the poor methodological quality and heterogeneity of the included studies. To better understand the efficacy and safety of <em>Piper longum</em>, well-designed trials with rigorous methodologies and transparent reporting are necessary.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102559"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yifei moxibustion treatment for acute exacerbations of asthma: study protocol for a randomized controlled trial","authors":"Jiaxin Xu ,&nbsp;Peng Zhang ,&nbsp;Jianya Yang ,&nbsp;Yang Xie ,&nbsp;Donghui Huang ,&nbsp;Cuiling Feng ,&nbsp;Suyun Li","doi":"10.1016/j.eujim.2025.102552","DOIUrl":"10.1016/j.eujim.2025.102552","url":null,"abstract":"<div><h3>Introduction</h3><div>Asthma is one of the most prevalent global chronic respiratory diseases and significantly impairs patients' quality of life. Yifei moxibustion is an external therapy that involves herb-partitioned moxibustion along the Governor Channel (Du Meridian). While Yifei moxibustion has demonstrated therapeutic potential in managing chronic airway disease through extensive clinical application, its efficacy in asthma treatment remains insufficiently validated, due to the absence of rigorously controlled, high-quality randomized clinical trials. This study aims to systematically evaluate the clinical efficacy and safety of Yifei moxibustion in asthma management while preliminarily investigating its correlation with immune regulation.</div></div><div><h3>Methods</h3><div>This is a multicenter, open-label, randomized controlled trial. A total of 384 participants with poorly controlled asthma will be randomly allocated to the Yifei moxibustion group and the usual care control group at a 1:1 ratio. The Yifei moxibustion consists of 90-minute sessions every 10 days, starting 10 days before the first Sanfu day. Each year includes 5 treatment sessions, for a total of 2 years of treatment. The primary outcome measure is the frequency of acute exacerbations. Secondary outcomes comprise Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), and Asthma Quality of Life Questionnaire (AQLQ) scores. All the above outcomes will be assessed before treatment, after treatment, and every 13 weeks during the follow-up period. Pulmonary function and fractional exhaled nitric oxide (FeNO) measurements will be conducted at baseline, 52 weeks, and 104 weeks. Laboratory blood biochemical analysis will be carried out at baseline, 7, 52, 59 and 104 weeks. The adverse events of the Yifei moxibustion will be evaluated at each treatment session and follow-up period.</div></div><div><h3>Conclusion</h3><div>This trial will evaluate the efficacy and safety of Yifei moxibustion in managing acute asthma exacerbations while preliminarily investigating its correlation with immune regulation, providing clinical references for asthma treatment.</div></div><div><h3>Trial registration</h3><div>Clinical Trials.gov NCT 06777472. Registered on 10 January 2025.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102552"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mushrooms, gut microbiota and cancer: A scoping review of preclinical studies and emerging human data","authors":"Kirsten Chick,&nbsp;Lisa Dowling,&nbsp;Karen Charlesworth","doi":"10.1016/j.eujim.2025.102525","DOIUrl":"10.1016/j.eujim.2025.102525","url":null,"abstract":"<div><h3>Introduction</h3><div>Cancer is a leading cause of death worldwide. The use of mushrooms is popular within integrative oncology, and in exploring their anti-cancer mechanisms, attention has turned to the role of mushroom-driven changes to gut microbiota. The aim of this paper is to map and synthesise the evidence that examines the impact of mushrooms on cancer-related immunological processes due to their potential interaction with the gut microbiota.</div></div><div><h3>Methods</h3><div>PubMed, the Cochrane Library and the Allied and Complementary Medicine Database were searched using the primary search terms “Cancer”, “Microbiota” and “Mushrooms”. Relevant data were tabulated, and studies were critically appraised and qualitatively analysed.</div></div><div><h3>Results</h3><div>140 studies were screened and 23 identified (20 murine, one <em>in vitro</em>, one <em>in silico</em>, and one human cross-sectional). The most frequent mushroom and cancer studied were <em>Ganoderma lucidum</em> and colorectal cancer, respectively. Twenty-two studies reported statistically significant gut microbiota changes, eight of which found changes to diversity, two identified changes to the <em>Firmicutes/Bacteroidetes</em> (F/B) ratio, four found restored cancer-related pathways in gene pathway enrichment analysis, and six found increased short chain fatty acids (SCFAs) produced by gut microbiota. One study identified anti-cancer pathways via computer modelling of mushrooms and human gut microbiota. 85% of murine studies found evidence of tumour reduction, and 12 studies found changes to cytokines.</div></div><div><h3>Conclusions</h3><div>In mice, mushrooms resulted in favourable changes to tumour measurements, SCFA activity and gut microbiota gene pathway enrichment. Inconsistent changes were reported in other outcomes, and the complexity of the gut microbiome and immunity makes these findings difficult to interpret. Results from murine studies are difficult to extrapolate to humans, and human studies are lacking. Further human studies are therefore recommended, and <em>in silico</em> research may prove valuable as technologies progress. The findings of this review are insufficient to inform any kind of treatment protocol, and further research is recommended.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102525"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}