European Journal of Integrative Medicine最新文献

{"title":"Guidance on assessing efficacy and harms in traditional Chinese medicine dietotherapy: Introducing the Dietotherapy Intention, Evaluation, and Harm Tracking (DIET) pathway","authors":"Lixia Yuan ,&nbsp;Jianrong Chen ,&nbsp;XunXun Yuan ,&nbsp;Jieyi Zhou ,&nbsp;Sheng Xu ,&nbsp;Weifeng Zhu ,&nbsp;Xu Zhou","doi":"10.1016/j.eujim.2024.102367","DOIUrl":"10.1016/j.eujim.2024.102367","url":null,"abstract":"<div><h3>Introduction</h3><p>Traditional Chinese medicine (TCM) dietotherapy, based on the principle of “medicine and food homology”, is widely used across diverse healthcare domains. However, the dual attributes of “medicine” and “food” possessed by medicinal and edible herbs make it challenging to assess the efficacy and harms of TCM dietotherapy using currently available methodological systems. This limits the advancement of health services and regulations in this field. This study introduces the Dietotherapy Intention, Evaluation, and Harm Tracking (DIET) pathway, a staged approach for assessing the efficacy and harms of TCM dietotherapy.</p></div><div><h3>Results</h3><p>The DIET pathway was developed through comprehensive analysis and two rounds of Delphi expert consensus. Based on the distinct characteristics and management requirements of TCM dietotherapy, the DIET pathway divides the assessment process into three stages: Stage 1 (Intention) aims to establish intended efficacy goals, Stage 2 (Evaluation) aims to validate efficacy and harms, and Stage 3 (Harm Tracking) aims to assess harms in special scenarios. Elaborate methodological guidelines are provided for each stage.</p></div><div><h3>Conclusion</h3><p>The DIET pathway has created a methodological environment that enables systematic and efficient assessment of the efficacy and harms of TCM dietotherapy regimens, which will facilitate the application and management of TCM dietotherapy.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102367"},"PeriodicalIF":2.5,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141031466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical characterization of Thymus zygis L. (thyme) and Elettaria cardamomum L. (cardamom) essential oils and investigation of their inhibitory potentials against cervicovaginal Escherichia coli isolates","authors":"Gulcan Sahal ,&nbsp;Hanife Guler Donmez ,&nbsp;Mehmet Sinan Beksac","doi":"10.1016/j.eujim.2024.102366","DOIUrl":"10.1016/j.eujim.2024.102366","url":null,"abstract":"<div><h3>Introduction</h3><p>The cervicovaginal microbiota plays a crucial role in women's well-being and reproductive health. This study initially focuses on identifying the chemical components of the essential oils (EOs) from <em>Elettaria cardamomum</em> L. (cardamom) (Ec) and <em>Thymus zygis</em> L. (thyme) (Tz). Subsequently, this study aims to determine the antimicrobial and biofilm inhibitory effects of these EOs against both cervicovaginal mixed cultures and the microbial strains isolated from them.</p></div><div><h3>Methods</h3><p>The compositions of EOs were determined by GC–MS analysis using an Agilent 7890B GC/5977A Series MSD System. Cervicovaginal samples were obtained from two women presenting complaints of a strong odor and vaginal discharge. Samples were collected from the cervix using a sterile cytobrush, ensuring no contact with the urethra, rectum, or external parts of the vagina. The cytological examination was conducted using Papanicolaou staining. Isolated microorganisms were identified through 16S Ribosomal RNA Gene Sequence Analysis and characterized using antibiogram tests. Antimicrobial tests of the EOs were performed by broth microdilution and disc diffusion methods. Biofilm formation was assessed using a crystal violet binding assay.</p></div><div><h3>Results</h3><p>The major components of Ec EO were <em>α</em>-terpinyl acetate (41.95 %) and eucalyptol (28.58 %), whereas Tz EO contained significant amounts of <em>o</em>-cymene (38.76 %), carvacrol (22.66 %), and thymol (20.69 %). <em>Escherichia coli</em> codes OR651248 and OR651249 were isolated from CV 6 and CV 7 mixed cultures, respectively. <em>E. coli</em> OR651248 demonstrated a higher antibiotic resistance level than <em>E. coli</em> OR651249. Biofilm formation by mixed cultures was significantly higher than that by <em>E. coli</em> isolates (<em>P</em> &lt; 0.05). The Ec EO displayed minimal to no effect against both mixed cultures, showing zero inhibition zone, 500 μL/mL minimum inhibitory concentrations (MICs), and 500 μL/mL minimum microbicidal concentrations (MMCs). However, the Tz EO exhibited antimicrobial activity against both mixed cultures and the <em>E. coli</em> isolates, with inhibition zones &gt; 15 mm and MICs/MMCs &lt; 4 μL/mL (<em>P</em> &lt; 0.05). In all microbial cultures, 0.5 MIC of both EOs inhibited biofilm formation by more than 80 %.</p></div><div><h3>Conclusion</h3><p>The Tz EO exhibits promising potential as an antimicrobial and biofilm inhibitory agent for managing cervicovaginal <em>E. coli</em> infections.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102366"},"PeriodicalIF":2.5,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of clinical trials in integrative medicine: The issue of personalization","authors":"Kam Wa Chan ,&nbsp;Jian-ping Liu ,&nbsp;Zhao-xiang Bian","doi":"10.1016/j.eujim.2024.102365","DOIUrl":"10.1016/j.eujim.2024.102365","url":null,"abstract":"<div><h3>Introduction</h3><p>Classic randomized controlled trial design provides information about the effectiveness of a treatment at population level. In clinical practice based on precision medicine, we seek study designs that provide estimates accounting for individual patients’ demographics and context. Integrative medicine has a strong emphasis on personalization, and there is a pressing need for advancements in trial design to support clinical decisions.</p></div><div><h3>Discussion</h3><p>To enhance the generalizability and implementation of research evidence, study designs first need to mimic the real-world from both the clinicians’ and patients’ perspectives, which could be optimized based on stakeholder analysis. Previous stakeholder analyzes showed that the lack of personalization in clinical trial design is a key challenge for the adoption of evidence clinically. Variations of randomized controlled trial design including better-powered and better-designed subgroup analysis, pragmatic design, the N-of-1 cross-over design, and adaptive design have been introduced to personalize clinical trials. Each of these variations has unique advantages, assumptions and limitations. Stratified randomization can be used to divide a disease population into subgroups according to different schools of theory to match with the corresponding treatment, while preserving the generalizability to general readership. Patient-level meta-analysis can improve the power and precision of subgroup analysis. Enrichment design can increase the efficiency of a trial in detecting treatment effect(s) and in mimicking actual clinical use. Practical issues, including bias control and assessment in pragmatic trials, and N-of-1 trials are also discussed with recent trials as examples. We suggest strategies to maximize the validity and translation potential of clinical trials in integrative medicine with pragmatic or personalized design.</p></div><div><h3>Conclusion</h3><p>Variations of randomized controlled trial design improve the precision of estimates at patient level, which should be carefully considered in the trial design of integrative medicine according to the context of the future application of evidence.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102365"},"PeriodicalIF":2.5,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of guided imagery pre-cesarean section on the perceived preoperative anxiety, surgical fear, and physiological parameters of women: A randomized controlled trial","authors":"Menekşe Nazlı Aker,&nbsp;Hatice Öner Cengiz,&nbsp;Neslihan Yilmaz Sezer","doi":"10.1016/j.eujim.2024.102362","DOIUrl":"10.1016/j.eujim.2024.102362","url":null,"abstract":"<div><h3>Introduction</h3><p>Guided imagery (GI) helps patients feel happy, relaxed, calm, and safe while ensuring positive thinking. This study was conducted to investigate the impact of GI applied before cesarean section (CS) on preoperative anxiety, surgical fear, and physiological parameters.</p></div><div><h3>Methods</h3><p>Participants were randomized into the GI (<em>n</em> = 29) or control (<em>n</em> = 28) groups in this randomized controlled trial. Participants in the GI group were given a 15-minute GI audio recording three days before their CS and were allowed to listen to it every night for 3 days until the CS. Finally, they listened on the day of the CS, immediately after preparing for the CS. Anxiety levels were evaluated using the State Anxiety Inventory-S (STAI-S) 3 days before the CS (STAI-S1) and 15 min after the preparations on the CS morning (STAI-S2); while surgical fear was evaluated using the Surgical Fear Questionnaire (SFQ) 3 days before the CS (SFQ1-Total) and 15 min after the preparations on the CS morning (SFQ2-Total). Blood pressure, temperature, heart rate, respiratory rate, and fetal heart rate were also evaluated.</p></div><div><h3>Results</h3><p>A significant difference in the mean STAI-S scores was observed 15 min after the preparations for the CS between the GI and control groups (mean difference (MD) -4.51, 95 % confidence intervals (CIs) [-7.71, -1.31]). However, no significant difference was found in the mean SFQ scores between the groups (MD -5.53, 95 %CIs [-16.69, 5.63]). In the within group comparison of GI and the control group, no statistically significant difference was observed in the score means of the GI group (STAI-S1 with STAI-S2 and SFQ1-Total with SFQ2-Total). However, the score means of the control groups STAI-S2 was higher than STAI-S1 (MD -5.82, 95 %CIs [-8.16, -3.48]), and SFQ2-Total was higher than SFQ1-Total (MD -6.71, 95 %CIs [-10.97, -2.46]). No significant difference was found in physiological parameters between the groups.</p></div><div><h3>Conclusion</h3><p>This study revealed the effectiveness of GI during the period before CS in reducing preoperative anxiety and keeping surgical fear under control. Nurses and other healthcare professionals involved in preoperative care can utilize GI to reduce preoperative anxiety and manage surgical fear before a CS.</p></div><div><h3>Clinical trial registration</h3><p>NCT05790954</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102362"},"PeriodicalIF":2.5,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collaborative design of a Chinese herbal medicine case report guideline (CHM-CARE)","authors":"Brigitte Linder ,&nbsp;Guo-Yan Yang ,&nbsp;Kathleen Lumiere ,&nbsp;Lisa Taylor-Swanson ,&nbsp;Sandro Graca ,&nbsp;Mike Armour","doi":"10.1016/j.eujim.2024.102364","DOIUrl":"https://doi.org/10.1016/j.eujim.2024.102364","url":null,"abstract":"<div><h3>Introduction</h3><p>Case reports have a long history in Chinese herbal medicine (CHM), and even into the modern day, case reports are still a preferred format for traditional East Asian medicine (TEAM) practitioners. However, the tradition of case reports in teaching and research is not nearly as common in the English-speaking world as in China, possibly due to the lack of a specific case report guideline. This study aimed to co-design a CHM guideline (CHM-CARE) to assist practitioners in compiling structured and comprehensive case reports.</p></div><div><h3>Methods</h3><p>A two-phased mixed approach was used to develop the case report guideline. In phase one, focus groups of TEAM practitioners were used to determine what components of existing guidelines (e.g., Case Report (CARE) and Case Report in Chinese Medicine (CARC)) were relevant to include, along with any additions or changes. Content analysis of phase 1 provided the checklist items for a two-round Delphi process (Phase 2). All checklist items from the first Delphi round with a median of three or higher were included in the second round, with consensus set at &gt;70 % for inclusion in the final guideline.</p></div><div><h3>Results</h3><p>A total of 18 CHM practitioners from four countries joined five separate focus group discussions. Focus group discussions led to 98 checklist items being used in the first round of the Delphi process. Fifteen international experts on case reports participated in two rounds of Delphi. A total of 69 checklist items moved forward into the second round where 61 items (88 %) reached consensus and formed the final CHM-CARE guideline.</p></div><div><h3>Conclusion</h3><p>Key elements of a herbal medicine case report checklist were identified, and a 61-item case report guideline (CHM-CARE) was produced, providing clear guidelines for case reports to TEAM practitioners operating in private practice.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102364"},"PeriodicalIF":2.5,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000349/pdfft?md5=5127bbf54801801e63ce09c599b36635&pid=1-s2.0-S1876382024000349-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing integrative healthcare in practice","authors":"Vincent Chung ,&nbsp;Herman van Wietmarschen ,&nbsp;William Cho ,&nbsp;Ava Lorenc ,&nbsp;Jennifer Hunter ,&nbsp;Susan Wieland","doi":"10.1016/j.eujim.2024.102363","DOIUrl":"10.1016/j.eujim.2024.102363","url":null,"abstract":"","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102363"},"PeriodicalIF":2.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanolic extract of Euphorbia Gypsicola induces differentiation and apoptosis in human myeloid leukemia K562 cells","authors":"Monireh Zare ,&nbsp;Sina Soltani ,&nbsp;Mohammad Javad Dehghan-Nayeri ,&nbsp;Reza Rahbarghazi ,&nbsp;Hojjatollah Nozad Charoudeh ,&nbsp;Majid Mahdavi","doi":"10.1016/j.eujim.2024.102361","DOIUrl":"https://doi.org/10.1016/j.eujim.2024.102361","url":null,"abstract":"<div><h3>Introduction</h3><p>The <em>Euphorbiaceae</em> family, widely distributed and long utilized in traditional medicine, has been recognized for its potential in developing anti-cancer drugs. The current study investigates the capacity of <em>Euphorbia gypsicola</em> extract to induce apoptosis and differentiation in the human myeloid leukemia K562 cell line.</p></div><div><h3>Methods</h3><p>Cell viability was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptotic activity was visually evaluated through acridine orange/ethidium bromide (AO/EB) dye staining and annexin V/PI double labeling procedures. Induction of differentiation was examined using nitro blue tetrazolium (NBT) reduction and Wright-Giemsa staining assays. The expression of apoptosis-related proteins including Bax, Bcl2 and Survivin was evaluated by western blotting method.</p></div><div><h3>Results</h3><p>The <em>E. gypsicola</em> extract exhibited potent medication properties with IC₅₀ values of 207.59, 48.58, and 7.08 ng/mL at 24, 48, and 72 h, respectively. Fluorescence microscopy, DNA fragmentation, annexin V/PI double staining, and sub-G1 cell cycle arrest confirmed apoptosis occurrence in K562 cells treated with the <em>E. gypsicola</em> extract. Our findings demonstrated that differentiated cells reduced NBT yellow solution after endocytosis, forming dark crystals. Wright Giemsa staining observations indicated a decrease in nuclear volume-to-cytoplasm ratio in K562 cells treated with the crude extract, signifying Induction of differentiation. Furthermore, western blot analysis revealed down-regulation of Survivin protein expression and up-regulation of Bax protein level following treatment with the <em>E. gypsicola</em> extract. However, no significant decrease in Bcl2 protein expression level was observed in K562 cells.</p></div><div><h3>Conclusion</h3><p>These findings indicate the growth inhibitory effects of the <em>E. gypsicola</em> extract on leukemia K562 cells, which supports the further study of this plant to discover novel therapeutic compounds for the treatment of leukemia.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102361"},"PeriodicalIF":2.5,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of home-based acupressure on constipation in people with spinal cord injury: A study protocol for a randomized controlled trial with a mixed-method approach","authors":"Yan Li ,&nbsp;Jiaying Li ,&nbsp;Mengqi Li ,&nbsp;Yuen Shan Ho ,&nbsp;Tsz Ching Sun ,&nbsp;Shanshan Wang ,&nbsp;Wai Kit Wong ,&nbsp;Shiping Zhang ,&nbsp;Rick Kwan ,&nbsp;Arnold YL Wong ,&nbsp;Wing Fai Yeung","doi":"10.1016/j.eujim.2024.102360","DOIUrl":"10.1016/j.eujim.2024.102360","url":null,"abstract":"<div><h3>Introduction</h3><p>People with spinal cord injuries often experience constipation. Common surgical and conservative treatments for constipation may have long-term adverse events that outweigh their benefits in relieving symptoms temporarily. This proposed study aims to investigate the effects of acupressure on constipation, quality of life, psychosocial well-being, and bowel habits in a community-based spinal cord injury population.</p></div><div><h3>Methods</h3><p>This two-parallel-group, open-label controlled trial will randomly assign 78 eligible participants to the intervention or control groups. After receiving defecation education, the intervention group will perform 10-days of self-operated or caregiver-assisted acupressure manually, while the control group will conduct a manual light touch on the abdomen. The study will assess participants' constipation severity as the primary outcome, along with secondary outcomes including quality of life, psychosocial well-being, bowel habits, and participants’ perceptions of acupressure. Participants' perceptions of acupressure will be assessed through semi-structured focus group interviews after intervention. Other measurements will be taken at baseline, immediately post-intervention, and at a 1-month follow-up. The generalized estimating equations and content analysis will be employed to analyze the intervention effect and interview data, respectively.</p></div><div><h3>Discussion</h3><p>This study will be the first to evaluate the effect of applying acupressure in people with spinal cord injuries to improve their constipation. The intervention may offer an alternate, non-invasive therapy option for individuals with spinal cord injuries who live in the community.</p></div><div><h3>Trial registration</h3><p>This study is registered on ClinicalTrials.gov, ID: NCT05558657. Register date: September 28, 2022.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102360"},"PeriodicalIF":2.5,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000301/pdfft?md5=42e3201bdd34068191f2f6bbe3d1171d&pid=1-s2.0-S1876382024000301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an adverse event reporting template for Ephedrae Herba for weight loss","authors":"Soobin Jang ,&nbsp;Mi Mi Ko ,&nbsp;Bo Young Kim ,&nbsp;Mi Ju Son ,&nbsp;Kyung Hwan Jegal ,&nbsp;Jeong Hwan Park ,&nbsp;Sungha Kim","doi":"10.1016/j.eujim.2024.102341","DOIUrl":"10.1016/j.eujim.2024.102341","url":null,"abstract":"<div><h3>Introduction</h3><p>Ephedrae Herba is a medicinal herb that has been frequently used for weight loss for several centuries. However, there are concerns regarding the safety and potential adverse events (AE) associated with Ephedrae Herba. This study aimed to develop a template suitable for reporting the AE of a Ephedrae Herba as a weight loss treatment in a clinical setting.</p></div><div><h3>Methods</h3><p>An initial consensus questionnaire was developed based on a literature review and discussion with the project management group. Delphi votes were performed, and three indices – content validity ratio, consensus, and convergence–were used to determine the core symptoms to be reported as AE. Finally, 12 Korean medicine doctors used the template for 1,043 patients from the Korean Medicine Registry of Herbal Medicine for weight loss, and evaluated its applicability.</p></div><div><h3>Results</h3><p>Following a two round Delphi survey, six items reached a consensus as the core symptoms of AE in Ephedrae Herba: headache, nausea, palpitations, dry mouth, constipation, and insomnia. The template has two main domains: (1) prescription of the herbal medicine, including Ephedrae Herba, and the dose and usage period; and (2) periods, severity, and causality of AE.</p></div><div><h3>Conclusions</h3><p>This is the first template specifically for reporting the AE of Ephedrae Herba. This template will help collect data in daily practice regarding the AE associated with Ephedrae Herba use for weight loss. This study could be valuable for practitioners who prescribe herbal medicines, including Ephedrae Herba, and stakeholders who manage the AE of herbal medicines to obtain long-term safety information associated with Ephedrae Herba.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"67 ","pages":"Article 102341"},"PeriodicalIF":2.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187638202400012X/pdfft?md5=a7e84eda52d2fb17ef77ef761abe41be&pid=1-s2.0-S187638202400012X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting a dutch integrative medicine research agenda: Results of a consensus-based strategy","authors":"Herman A. van Wietmarschen ,&nbsp;Annemarie Kapteijns ,&nbsp;Martine Busch ,&nbsp;Ines von Rosenstiel ,&nbsp;Rogier H.J. Hoenders ,&nbsp;Erik W. Baars","doi":"10.1016/j.eujim.2024.102353","DOIUrl":"10.1016/j.eujim.2024.102353","url":null,"abstract":"<div><h3>Introduction</h3><p>The WHO Traditional Medicine Strategy 2014–2023 emphasises the significance of traditional medicine systems for preventing and treating diseases, worldwide. As a result, many countries have developed national research programmes and research institutes dealing with traditional, complementary and integrative medicine (TCIM) (WHO Global Report on Traditional and Complementary Medicine, Geneva, 2019) or integrative medicine (IM). Despite considerable public interest in IM in the Netherlands, no Dutch programme or research institute has been established, yet. In 2018, a consortium for integrative care and health was founded, and developed a national research agenda with research priorities for the Netherlands.</p></div><div><h3>Methods</h3><p>The consensus-based strategy for developing the research agenda involved: (1) conducting a literature review, (2) organising an online consensus meeting with a select group of integrative medicine (IM) experts, (3) conducting a survey among IM stakeholders, and (4) organising a second consensus meeting with the same group of IM experts to discuss the survey results and further refine the research agenda. Snowball sampling was used to recruit IM stakeholders, starting from a list of those interested in or connected to IM.</p></div><div><h3>Results</h3><p>Ninety-two stakeholders completed the survey. The most promising research areas were oncology, pain management and palliative care. Respondents awarded the highest priority to research on the effectiveness, cost-effectiveness and safety of IM interventions. Directions for research included mind–body interventions, biological interventions and whole medical systems. Moreover, respondents strongly recommended developing reliable patient information tools. Facilitators for IM implementation were increasing attention on prevention, the rising incidence of chronic diseases and the shift from disease-focused to health-focused approaches. The identified barriers included a lack of knowledge about IM, the absence of health insurance reimbursement for complementary medicine, and governance structures of healthcare organisations.</p></div><div><h3>Conclusions</h3><p>The first Dutch IM research agenda was developed based on consensus among Dutch healthcare professionals, along with input from a smaller group of patients and researchers. This agenda provides clear research directions and distinguishes both positive developments and barriers for IM in the Netherlands.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"67 ","pages":"Article 102353"},"PeriodicalIF":2.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}