European Journal of Integrative Medicine最新文献

{"title":"Effectiveness of scalp acupuncture therapy combined with training on limb movement disorders after stroke: A systematic review and meta-analysis","authors":"Yenan Tian ,&nbsp;Peizhen Zhao ,&nbsp;Yongjun Peng","doi":"10.1016/j.eujim.2025.102432","DOIUrl":"10.1016/j.eujim.2025.102432","url":null,"abstract":"<div><h3>Introduction</h3><div>Stroke patients often suffer from different degrees of disability, among which limb movement disorders (LMDs) are the most prevalent. Scalp acupuncture (SA) therapy combined with training has been widely used for LMD treatment after stroke. Whether SA therapy combined with training is superior to monotherapy or other therapies remains unknown. This review aimed to evaluate the effectiveness and safety of SA therapy combined with training for LMDs after stroke.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, Web of Science, and Cochrane Library databases were thoroughly searched for studies from inception to November 23, 2024. Fugl-Meyer Assessment (FMA), Modified Ashworth Scale (MAS), Berg Balance Scale (BBS), and Modified Barthel Index (MBI) were used to evaluate the effectiveness of SA therapy combined with training in treating LMDs after stroke. Weighted mean differences (WMDs) were calculated.</div></div><div><h3>Results</h3><div>A total of 4345 records were initially identified, and 26 studies were finally included. Compared to simple training, SA therapy combined with training had significant effects in the total score of FMA (WMD= 10.01, 95 %CI= 2.24, 17.78), the upper-extremity score of FMA (WMD= 6.35, 95 %CI=4.11, 8.59), the lower-extremity score of FMA (WMD= 2.69, 95 %CI= 1.49, 3.90), MAS (WMD= -0.47, 95 %CI= -0.72, -0.22), BBS (WMD= 3.52, 95 %CI= 0.55, 6.48), and MBI (WMD= 7.72, 95 %CI= 4.97, 9.56). No significant difference was found in adverse events (RR= 6.97, 95 %CI= 2.10, 23.11, <em>P</em> = 0.33). More significant effects in FMA-L and MAS were revealed after 12 weeks of treatment (all P _interaction&lt;0.01).</div></div><div><h3>Conclusion</h3><div>SA therapy combined with training can significantly improve FMA, MAS, BBS, and MBI to enhance limb function, with favorable safety profiles. 12 weeks of SA therapy combined with training often yields better improvements in lower limb motor function and limb spasticity. More RCTs of higher quality are needed to provide reliable support for these conclusions.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"74 ","pages":"Article 102432"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of obesity-related parameters and dietary habits on Chinese medicine body constitutions: A mediation analysis based on Taiwan Biobank Research Database","authors":"Ping-Ho Chen ,&nbsp;Su-Chen Fang ,&nbsp;Shu-fen Shen ,&nbsp;Chen-Jung Chen ,&nbsp;Wan-Ling Lin ,&nbsp;Sheng-Miauh Huang","doi":"10.1016/j.eujim.2025.102431","DOIUrl":"10.1016/j.eujim.2025.102431","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese medicine (TCM) theory believes that diet is very important in changing body constitution and preventing diseases because food is similar to medicine. This study aimed to explore the effects of obesity-related parameters and dietary habits on TCM body constitution in Taiwanese people.</div></div><div><h3>Methods</h3><div>This study applied an observational cross-sectional design. Individuals were selected from the Taiwan Biobank Research Database. The body constitution questionnaire (BCQ) and food frequency questionnaire (FFQ) were administered. Yin deficiency, yang deficiency, and stasis in TCM were assessed by BCQ. Obesity-related parameters were defined as body weight, body fat, and body mass index (BMI). Multiple linear regression and mediation analyses were conducted.</div></div><div><h3>Results</h3><div>A total of 16,790 individuals were enrolled in the study. Individuals with higher FFQ scores and BMI had better yang deficiency, yin deficiency, and stasis patterns. Those with higher body weight and body fat had poor yang deficiency, yin deficiency, and stasis patterns. After adjusting for potential confounders, all obesity-related parameters partially mediated the association between the FFQ and yang deficiency or stasis patterns. Only body weight partially mediated the association between the FFQ and yin deficiency patterns.</div></div><div><h3>Conclusion</h3><div>Dietary habits and obesity-related parameters have direct effects on TCM body constitutions. Healthy dietary habits have an indirect effect on TCM body constitutions through obesity-related parameters, especially for yang deficiency and stasis patterns. Further studies are needed to confirm and understand the potential mechanisms, including innate physiological and environmental factors, underlying these findings.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"74 ","pages":"Article 102431"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture therapy for vasomotor symptoms in breast cancer: Protocol for a prospective, multicenter, case registry study","authors":"Jia-Shan Li ,&nbsp;Zi-Yan Li ,&nbsp;Xing-Fang Pan ,&nbsp;Zhuo-Xin Yang ,&nbsp;Jia Liu ,&nbsp;Xin Wang ,&nbsp;Hong-Jiao Li ,&nbsp;Lin Luo ,&nbsp;Bo Chen ,&nbsp;Bao-Yan Liu ,&nbsp;Yi Guo ,&nbsp;Li-Yun He ,&nbsp;Tian-Yi Zhao","doi":"10.1016/j.eujim.2025.102429","DOIUrl":"10.1016/j.eujim.2025.102429","url":null,"abstract":"<div><h3>Introduction</h3><div>Adjuvant endocrine therapy for breast cancer has advantages such as reducing the incidence of recurrence. However, adjuvant endocrine therapy may cause adverse vasomotor symptoms. Although randomized controlled trials (RCTs) have shown that acupuncture therapy is an effective treatment for vasomotor symptoms in patients with breast cancer, a practical real-world acupuncture regimen has yet to be established. Therefore, there is an urgent need for a case registry study that provides real-world evidence for the effectiveness of acupuncture therapy in treating vasomotor symptoms. This article presents the protocol for a case registry study that aims to provide an overview of the acupuncture therapy for managing vasomotor symptoms in patients with breast cancer.</div></div><div><h3>Methods</h3><div>The study cohort will comprise patients with breast cancer with vasomotor symptoms who are aged between 18 and 70 years and are undergoing adjuvant endocrine therapy. Patients will be recommended to receive acupuncture therapy, without excluding other treatments. The primary outcome is the patient-reported change in the hot flashes score. Electronic case report forms will be used to record patient demographic characteristics, information about interventions, and information about medical personnel from week 1 to 8, with a subsequent follow-up period of 24 weeks. At least 250 patients will be recruited from six medical hospitals. Adverse events will be monitored and recorded. An appropriate mixed model will be used to analyze the factors potentially influencing the effects of acupuncture therapy.</div></div><div><h3>Discussion</h3><div>This multicenter, prospective, observational, case registry study will bridge the gap between the clinical practices of acupuncture therapy and the evidence established through RCTs and systematic reviews. The findings will provide knowledge to better inform regulatory decision-making.</div></div><div><h3>Conclusion</h3><div>The findings of this case registry study will identify subgroups of patients with breast cancer that will benefit from acupuncture therapy for vasomotor symptoms.</div></div><div><h3>Registration</h3><div>This study was registered in the Chinese Clinical Trial Registry (ChiCTR2400081274)</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"74 ","pages":"Article 102429"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the therapeutic potential of elemene emulsion injection as an adjuvant for chimeric antigen receptor T cell therapy: Transcriptome analysis and experimental validation","authors":"Xiuying Liu ,&nbsp;Jingjing Zhu ,&nbsp;Jingjing Liu ,&nbsp;Yichao Feng ,&nbsp;Jiaying Wang ,&nbsp;Jianxun Wang","doi":"10.1016/j.eujim.2024.102425","DOIUrl":"10.1016/j.eujim.2024.102425","url":null,"abstract":"<div><h3>Introduction</h3><div>Elemene emulsion injection (EEI) is prepared from monomers extracted from Chinese medicine. It has been used as an adjuvant anti-tumor medication in clinical settings for over 30 years. Chimeric antigen receptor T cells (CAR-T) are a successful immunotherapy strategy for tumor treatment. This study aimed to investigate the role and potential mechanisms of EEI as an adjuvant to CAR-T cells for tumor treatment.</div></div><div><h3>Methods</h3><div>CCK8 staining was utilized to detect the effect of EEI on tumor cell viability. CD19 CAR-T and Trop2 CAR-T cells were constructed, and EEI was added to the experimental system. Untreated CAR-T cells served as a control group. After co-culture with tumor cells, the effect of EEI on CAR-T cell function was assessed. Flow cytometry, luciferase reporter gene, IncuCyte, and cytokine assays were used to evaluate the effects of the EEI on CAR-T cell cytotoxicity and phenotype <em>in vitro</em>. RNA sequencing was utilized to analyze the effect of EEI on CAR-T cell gene expression. Network pharmacology was applied to predict potential EEI therapeutic targets for CRS, which were verified via a THP-1 macrophage inflammation model.</div></div><div><h3>Results</h3><div>EEI enhanced the cytotoxicity of CAR-T cells against tumors. RNA-seq revealed that EEI modulated cytokine activity and Th17 cell differentiation in CAR-T cells. Subsequent experiments confirmed that the proportion of CD4+ <em>T</em> cells in CAR-T cells increased. The secretion of cytokines was greatly reduced under the effect of EEI. In the THP-1 macrophage inflammation model, EEI significantly reduced the levels of cytokines associated with inflammation induced by CAR-T cells.</div></div><div><h3>Conclusions</h3><div>This research proposed and tested a combination therapy involving EEI and CAR-T cells. The combination of CAR-T cells with EEI for tumor immunotherapy may enhance the clinical efficacy while providing synergistic effects and reducing toxicity.</div></div><div><h3>Funding</h3><div>Scientific Research Startup Funds for High-level Talents from Beijing University of Chinese Medicine (Grant No. 9,011,451,310,032)</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"73 ","pages":"Article 102425"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of acupuncture for the treatment of stress urinary incontinence: A systematic review and meta-analysis","authors":"Jiakun Zhang ,&nbsp;Zhongtong Ma ,&nbsp;Jintong Shi ,&nbsp;Wenjuan Shen ,&nbsp;Jiali Wei ,&nbsp;Mei Han","doi":"10.1016/j.eujim.2024.102417","DOIUrl":"10.1016/j.eujim.2024.102417","url":null,"abstract":"<div><h3>Introduction</h3><div>Stress urinary incontinence (SUI) is an involuntary loss of urine on physical exertion, sneezing, or coughing. Acupuncture, a worldwide accepted traditional and complementary medicine, has been widely used in China to treat SUI. This review aims to evaluate the effectiveness and safety of acupuncture for women with SUI.</div></div><div><h3>Methods</h3><div>The protocol was registered in PROSPERO (CRD42022361059) and this systematic review (SR) was funded by the National Administration of Traditional Chinese Medicine. Databases including China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database, SinoMed, Web of Science, PubMed, The Cochrane Library, and Embase were searched from their inception to October 2023, for relevant randomised controlled trials (RCTs) on the treatment of acupuncture with/without pelvic floor muscle training (PFMT). Study screening and data extraction were carried out independently by two authors. Methodological quality was evaluated using the Cochrane's risk of bias (RoB) tool 2.0. Meta-analysis was performed by RevMan 5.3.5.</div></div><div><h3>Results</h3><div>A total of 31 RCTs with 2885 patients were included in this SR. The results showed that the combination of acupuncture with PFMT had a better effect than PFMT only in decreasing urine leakage (RR = -1.87, 95 % CI [-2.24, -1.49], 13 studies, 956 patients) and Incontinence Questionnaire Short Form (ICI-Q-SF) scores (RR = -2.26, 95 % CI [-2.64, -1.88], 14 studies, 1015 patients) in women with SUI. Acupuncture compared with sham acupuncture demonstrated improvements in urinary leakage (RR = -4.22, 95 % CI [-5.52, -2.93], 5 studies, 286 patients), and ICI-Q-SF scores with MD and 95 % CI of -3.88(-4.59, -3.17), -8.71(-10.85, -6.57), and -3.10(-3.38, -2.82), respectively. Subgroup analyses of manual acupuncture or electroacupuncture and duration of PFMT treatment can appropriately reduce heterogeneity. For the Egger's test of 1-h pad leakage and of ICI-Q-SF scores, suggesting that there was a small possibility of publication bias in this SR (<em>p</em> = 0.1257 and <em>p</em> = 0.8058, respectively). Adverse events appeared in 12 participants in the acupuncture group and 9 in the sham group.(relative risk = 1.33, 95 % CI = [0.56, 3.15], <em>P</em> = 0.70). The quality of RCTs included in this review was generally poor.</div></div><div><h3>Conclusion</h3><div>Acupuncture has potential in the treatment of SUI in women, and no significant adverse events were reported. However, considering issues with the methodological quality of the included studies, the reliability of this review conclusion may be affected to a certain extent.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"73 ","pages":"Article 102417"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Reiki in the third trimester on breastfeeding self-efficacy, pregnancy-related complaints, and quality of life: Randomized controlled study","authors":"Seda Karaçay Yikar,&nbsp;Dilara Keklik,&nbsp;Evşen Nazik","doi":"10.1016/j.eujim.2024.102423","DOIUrl":"10.1016/j.eujim.2024.102423","url":null,"abstract":"<div><h3>Introduction</h3><div>This study was carried out to determine the effects of Reiki applied to pregnant women in the last trimester on breastfeeding self-efficacy, complaints during pregnancy, and quality of life.</div></div><div><h3>Methods</h3><div>The study was conducted as a two-group randomized controlled trial at a city hospital. A total of 68 pregnant women (34 in the Reiki group and 34 in the control group) receiving antenatal care participated in the study. The Reiki group received eight Reiki sessions, with the first being given face to face on the day they were enrolled in the study and seven remotely. Data were collected in three stages: on the first day of the study, four weeks after the first interview, and six weeks postpartum. Data were collected using a \"Personal Information Form, the ``Scale of Complaints during Pregnancy and Their Effect on Quality of Life (SCPEQL),'' and the ``Breastfeeding Self-Efficacy Scale (BSES).''</div></div><div><h3>Results</h3><div>The BSES scores of women in the Reiki and control groups yielded a significant difference between the first measurement and the one made after four weeks (MD 5.47, 95 % CIs [1.75 to 9.18]). There was no statistical difference between the BSES post-test scores of the groups (MD 2.92, 95% CIs [−0.65 to 6.48]). No significant difference was found between the mean SCPEQL scores of the groups, either (MD 11.47, 95% CIs [−27.03 to 4.09]). During the study, no adverse events were noted in either groups.</div></div><div><h3>Conclusions</h3><div>The results of this study showed that Reiki applied during pregnancy was effective in increasing women's breastfeeding self-efficacy, but there was no effect on the improvement of pregnancy-related complaints and quality of life.</div></div><div><h3>The clinical trial registration number</h3><div>NCT05942989.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"73 ","pages":"Article 102423"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of implementing clinical hypnosis and learning self-hypnosis with neurologists to improve well-being","authors":"Constance Flamand-Roze,&nbsp;Capucine Mouthon-Reignier,&nbsp;Nicolas Chausson,&nbsp;Didier Smadja","doi":"10.1016/j.eujim.2024.102428","DOIUrl":"10.1016/j.eujim.2024.102428","url":null,"abstract":"<div><h3>Introduction</h3><div>Numerous studies have highlighted the risk of burnout among neurologists. However, only a few suggest exploring the feasibility of implementing measures to help neurologists manage the anxiety and fatigue inherent in their profession. Furthermore, effective communication is crucial for workplace well-being. This study aimed to assess the feasibility of providing clinical hypnosis sessions to a group of neurologists and to instruct them in self-hypnosis and hypnotic communication methods, given the proven effectiveness of hypnosis.</div></div><div><h3>Methods</h3><div>We emailed 20 volunteer neurologists from the neurology department of the Centre Hospitalier Sud Francilien (CHSF, France), explaining the purpose and progress of our study. We employed surveys that included validated quantitative scales to evaluate fatigue, anxiety, depression, quality of life, workplace well-being, and communication in the department. Next, we conducted two practice and learning sessions focused on hypnosis, self-hypnosis, and communication techniques in two different groups. Each session lasted two hours and included a theoretical component, a recorded hypnosis session (20 min), or a role-playing segment to practice hypnotic communication techniques. Participants were encouraged to practice the exercises. After six months, the same evaluation questionnaires were given out again. We introduced a questionnaire to assess how regularly the exercises are practiced. The data were analyzed using frequencies, means, medians, and interquartiles.</div></div><div><h3>Results</h3><div>Out of the twenty neurologists, sixteen (80 %) participated in every session and finished all evaluation scales both before the sessions and six months later. Twelve participants (75 %) reported regularly using the practices. Responses suggested an improvement in fatigue at six months in eight participants, 12 experienced less anxiety and reported better quality of life. Participants who showed the most significant improvement frequently practiced hypnosis and communication techniques.</div></div><div><h3>Conclusion</h3><div>Using self-hypnosis and hypnotic communication demands personal commitment. However, those who practiced these methods tended to manage anxiety and fatigue more effectively. Regular practice is challenging but could eventually be a valuable strategy to enhance neurologists’ quality of life and communication. These practices are pretty simple to implement.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"73 ","pages":"Article 102428"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga therapy for eye health and disease: A scoping review","authors":"Deenadayalan Boopalan ,&nbsp;Archana Prabu Kumar ,&nbsp;Mahesh Kannan Vanamoorthy ,&nbsp;Venugopal Vijayakumar ,&nbsp;Poornima Ravi ,&nbsp;Madhesh Kasi ,&nbsp;Maheshkumar Kuppusamy","doi":"10.1016/j.eujim.2024.102427","DOIUrl":"10.1016/j.eujim.2024.102427","url":null,"abstract":"<div><h3>Introduction</h3><div>Yoga is widely practiced as a complementary, alternative, and integrative therapy to manage various health conditions. Existing literature indicates that yoga may play a role in eye care. The objective of this review was to investigate the available evidence of yoga in eye care.</div></div><div><h3>Methods</h3><div>This scoping review followed Arksey and O'Malley's framework and adhered to The Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for scoping reviews (PRISMA-ScR). It gathered literature from PubMed/MEDLINE, Scopus, the Cochrane Library, EMBASE, and Google Scholar using keywords and MeSH terms related to yoga and eye care, until 31st October 2024. The eligibility criteria for included studies were predefined using the PICO framework.</div></div><div><h3>Results</h3><div>A total of 29 studies, involving 1,938 participants aged 10 to 86 years, included healthy individuals and those with conditions like glaucoma, myopia, hypertension, and pseudoexfoliation syndrome. Interventions comprised asanas, pranayama, trataka, yogic ocular exercises, and relaxation techniques. Six studies reported reduced intraocular pressure (IOP), with other benefits including improved visual acuity, refractive power, and reduced eye strain. Adverse events included increased IOP, corneal thickness, and rare complications like vitreous detachment. Interventions varied in frequency and duration, with limited details on therapist training and supervision.</div></div><div><h3>Conclusions</h3><div>This scoping review highlights promising evidence supporting yoga therapy's role in promoting eye health and managing specific ocular conditions. However, further high quality randomized controlled trials are recommended to establish its safety, efficacy and to strengthen the clinical evidence.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"73 ","pages":"Article 102427"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of integrated Ayurveda treatment protocol in uncontrolled type 2 diabetes mellitus: A randomized controlled study","authors":"Suketha Kumari ,&nbsp;Rekha Patil ,&nbsp;Basavaraj R Tubaki","doi":"10.1016/j.eujim.2024.102424","DOIUrl":"10.1016/j.eujim.2024.102424","url":null,"abstract":"<div><h3>Introduction</h3><div>Uncontrolled type 2 diabetes mellitus (T2DM), measured as glycated hemoglobin (HbA1C) of &gt;7 %, is prevalent. An integrated Ayurveda treatment protocol (ITP) has potentially beneficial effects. This study aims to compare the efficacy of ITP with standard diabetic care in patients with uncontrolled T2DM.</div></div><div><h3>Methods</h3><div>This was a randomized, controlled, open-label clinical study. The study included patients (<em>n</em> = 200) with uncontrolled T2DM, on metformin (Glucophage) ≥1000 mg/day. Patients were randomized to either the standard treatment protocol (STP) or ITP group. The intervention in STP group was metformin (Glucophage) ≥ 1000mg/day with diet and lifestyle measures, while ITP group received metformin (Glucophage) ≥ 1000 mg /day, madhumehari ghana tab (ayurveda medicine), ayurvedic diet, and yoga for 90 days. The primary endpoint was a change in HbA1C. Secondary endpoints were homeostatic model assessment for insulin resistance (HOMA IR), fasting insulin, fasting blood glucose (FBG), postprandial blood glucose (PPBG), weight, body mass index (BMI), waist circumference, lipid profile, diabetes quality of life (DQOL), hemoglobin, and serum creatinine.</div></div><div><h3>Result</h3><div>Outcome difference assessment revealed significant improvement in HbA1C in ITP group compared with STP group (mean difference:1.04, 95 % confidence interval [CI]:1.27 to -0.80). ITP showed significant changes when compared to STP in HOMA IR (mean difference:1.41, 95 % CI:2.40 to -0.42), FBG (mean difference:22.25, 95 % CI:42.10 to -14.97), PPBG (-52.27, 95 % CI:70.50 to -34.05), serum triglycerides (mean difference:25.21, 95 % CI:42.30 to -8.12), and DQOL (mean difference:21.88, 95 % CI: 26.83 to -16.92). Furthermore, ITP group also demonstrated significant results in weight, BMI, body fat, visceral fat percentage, and body surface area. Comparable results were observed in serum insulin, total cholesterol, very low-density lipoprotein, and serum creatinine in between the groups. Changes were not significant for hemoglobin %, high-density lipoprotein, and low-density lipoprotein in both groups. There were mild adverse events in both groups, with 8 in STP group and 4 in ITP group.</div></div><div><h3>Conclusion</h3><div>ITP intervention produced significant improvements in glycemic parameters, insulin resistance parameters, anthropometric measures, and quality of life compared to standard care in uncontrolled T2DM.</div></div><div><h3>Clinical trial registration</h3><div>CTRI/2020/12/029,762</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"73 ","pages":"Article 102424"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Korean Medicine professions' perspectives on the applicability of ChatGPT in facial palsy practice: A web-based survey","authors":"Ji-Su Lee ,&nbsp;Sung-A Kim ,&nbsp;Taegon Kim ,&nbsp;Seunghoon Lee ,&nbsp;Tae-Hun Kim ,&nbsp;Jung Won Kang","doi":"10.1016/j.eujim.2024.102422","DOIUrl":"10.1016/j.eujim.2024.102422","url":null,"abstract":"<div><h3>Introduction</h3><div>Since November 2022, when Chat Generative Pre-trained Transformer (ChatGPT) was released, studies have been conducted to explore its potential use in various text-based areas. In the field of Korean Medicine (KM), studies evaluating the feasibility of ChatGPT are mainly focused on the educational domain. This study aimed to 1) identify the current level of ChatGPT-generated responses in answering questions from patients and KM practitioners, specifically exemplified by facial palsy and 2) explore the potential applicability of ChatGPT in KM practice through a perception survey of experts.</div></div><div><h3>Methods</h3><div>This study evaluates the applicability of ChatGPT concerning facial palsy through a survey of board-certified acupuncturists. The survey comprises two parts: assessing response quality for patients and for KM doctors in clinical practice. Ethical approval was obtained, and a 36-item questionnaire was administered online to 33 participants. Responses were analyzed for quality, relevance, and applicability using a combination of Likert scales and a standardized assessment tool.</div></div><div><h3>Results</h3><div>Among 33 eligible participants, 30 board-certified acupuncturists agreed to participate (response rate: 90.9 %). Survey results showed that the applicability of ChatGPT was lower for specialized KM practitioner inquiries than for general patient inquiries. Although the responses were considered useful to the readers (part 1: 96.7 %, part 2: 63.3 %) and understandable (part 1: 66.7 %, part 2: 60 %), the proportion of positive evaluations was relatively low in the domains assessing reliability and sufficiency.</div></div><div><h3>Conclusions</h3><div>Though ChatGPT is generally viewed positively for its potential utility, its direct application in KM clinical practice treating facial palsy at its current level seems challenging. To improve reliability, the information generated by ChatGPT should be critically reviewed by qualified expert medical personnel. To enhance sufficiency, further training of the artificial intelligence model with additional KM information is required.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102422"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}