European Journal of Integrative Medicine最新文献

{"title":"Exploring Korean Medicine professions' perspectives on the applicability of ChatGPT in facial palsy practice: A web-based survey","authors":"Ji-Su Lee ,&nbsp;Sung-A Kim ,&nbsp;Taegon Kim ,&nbsp;Seunghoon Lee ,&nbsp;Tae-Hun Kim ,&nbsp;Jung Won Kang","doi":"10.1016/j.eujim.2024.102422","DOIUrl":"10.1016/j.eujim.2024.102422","url":null,"abstract":"<div><h3>Introduction</h3><div>Since November 2022, when Chat Generative Pre-trained Transformer (ChatGPT) was released, studies have been conducted to explore its potential use in various text-based areas. In the field of Korean Medicine (KM), studies evaluating the feasibility of ChatGPT are mainly focused on the educational domain. This study aimed to 1) identify the current level of ChatGPT-generated responses in answering questions from patients and KM practitioners, specifically exemplified by facial palsy and 2) explore the potential applicability of ChatGPT in KM practice through a perception survey of experts.</div></div><div><h3>Methods</h3><div>This study evaluates the applicability of ChatGPT concerning facial palsy through a survey of board-certified acupuncturists. The survey comprises two parts: assessing response quality for patients and for KM doctors in clinical practice. Ethical approval was obtained, and a 36-item questionnaire was administered online to 33 participants. Responses were analyzed for quality, relevance, and applicability using a combination of Likert scales and a standardized assessment tool.</div></div><div><h3>Results</h3><div>Among 33 eligible participants, 30 board-certified acupuncturists agreed to participate (response rate: 90.9 %). Survey results showed that the applicability of ChatGPT was lower for specialized KM practitioner inquiries than for general patient inquiries. Although the responses were considered useful to the readers (part 1: 96.7 %, part 2: 63.3 %) and understandable (part 1: 66.7 %, part 2: 60 %), the proportion of positive evaluations was relatively low in the domains assessing reliability and sufficiency.</div></div><div><h3>Conclusions</h3><div>Though ChatGPT is generally viewed positively for its potential utility, its direct application in KM clinical practice treating facial palsy at its current level seems challenging. To improve reliability, the information generated by ChatGPT should be critically reviewed by qualified expert medical personnel. To enhance sufficiency, further training of the artificial intelligence model with additional KM information is required.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102422"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of acupuncture for perimenopausal insomnia: A systematic review and meta-analysis of randomized controlled trials","authors":"Luquan Qin ,&nbsp;Zhiyu Zhang ,&nbsp;Chuanfang Zhang ,&nbsp;Hua Zhou","doi":"10.1016/j.eujim.2024.102404","DOIUrl":"10.1016/j.eujim.2024.102404","url":null,"abstract":"<div><h3>Introduction</h3><div>Acupuncture is widely recognized as an alternative therapy for perimenopausal insomnia (PMI) in China, yet it lacks robust evidence-based support. This systematic review evaluated the efficacy and safety of acupuncture in treating PMI.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search for randomized controlled trials (RCTs) evaluating acupuncture for PMI across eight databases (PubMed, Cochrane Library, Web of Science, Embase, CNKI, CSPD, CSTJ, and CBM) from their inception until May 17, 2024. We assessed the risk of bias using the Cochrane risk-of-bias tool for randomized trials (RoB). and performed a random-effects meta-analysis and GRADE assessment.</div></div><div><h3>Results</h3><div>The meta-analysis included 16 studies with 1,112 participants. We found evidence supporting the effectiveness of acupuncture in improving several outcomes. Acupuncture significantly improved sleep quality compared to sham-acupuncture or waitlist control (Pittsburgh sleep quality index (PSQI) MD -3.94, 95 %CI [-5.52, -2.35], 6 RCTs, 412 participants, moderate certainty) and medication (PSQI MD -2.62, 95 %CI [- 4.11, -1.12], 7 RCTs, 520 participants, low certainty). Clinical improvement rates were higher for acupuncture compared to medication or waitlist (RR 1.38, 95 %CI [1.12, 1.69], <em>P</em> = 0.002, low certainty). Objective measures using wrist actigraphy monitor or polysomnography favoured acupuncture over sham-acupuncture or medication for improving sleep efficiency (SMD 1.00, 95 %CI [0.70, 1.31], 5 RCTs, 330 participants, moderate certainty), total sleep time (SMD 0.84, 95 %CI [0.61, 1.06], 5 RCTs, 330 participants, moderate certainty) and wake after sleep onset (SMD -0.80, 95 %CI [-1.20, -0.40], 4 RCTs, 281 participants, low certainty), but not sleep awakenings (SMD 0.03, 95 %CI [-0.22, 0.27] 4 RCTs, 256 participants, low certainty). The effects of acupuncture on the Kupperman index and follicle-stimulating hormone (FSH) were inconclusive due to insufficient data. Adverse events were infrequent and symptoms were generally mild. There was a lower risk of adverse events from acupuncture compared to medication (RR 0.05, 95 %CI [0.0, 0.83], 3 RCTs, 183 participants, low certainty) and no difference compared to sham acupuncture (RR 1.25, 95 %CI [0.5, 3.1], moderate certainty).</div></div><div><h3>Conclusion</h3><div>The current body of research suggests acupuncture is an effective and safe treatment option for PMI, offering benefits over Western medication, though the available evidence remains limited.</div></div><div><h3>Registration</h3><div>PROSPERO CRD42023443190</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102404"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical profiling of Prunus armeniaca kernel extracts and exploration of their multifaceted antioxidant and antibacterial effects through in vitro and in silico studies","authors":"Mohamed Amine El-Hajjaji ,&nbsp;Kawtar Fikri-Benbrahim ,&nbsp;Mohammed El Ouassete ,&nbsp;Nidal Naceiri Mrabti ,&nbsp;Najoua Soulo ,&nbsp;Asmae El Ghouizi ,&nbsp;Badiaa Lyoussi ,&nbsp;Zineb Benziane Ouaritini","doi":"10.1016/j.eujim.2024.102421","DOIUrl":"10.1016/j.eujim.2024.102421","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Prunus armeniaca</em> \"Apricot\" kernels are considered a by-product widely employed in traditional medicine for treating various ailments due to their potential therapeutic properties. The current investigation sought to assess the properties of aqueous and methanol extracts of <em>Prunus armeniaca</em> kernels (PAK).</div></div><div><h3>Methods</h3><div>The phytochemical composition of the studied extracts was evaluated using high-performance liquid chromatography with a diode array detector (HPLC-DAD). Total antioxidant capacity (TAC), β-carotene bleaching, reducing power (RP), and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays were used to assess antioxidant activity. Using the disc diffusion method and the microdilution test in 96-well microplates against four bacterial strains, the antimicrobial activity of the aforementioned extracts was evaluated. The potential of several phenolic compounds as bacterial inhibitors was assessed through extensive density functional theory (DFT) calculations and molecular docking analyses.</div></div><div><h3>Results</h3><div>The phytochemical analysis revealed the identification of several phenolic constituents, with tocopherol (11.61 ± 0.9 mg/g of dry extract) and resveratrol (25.3 ± 0.4 mg/g of dry extract) emerging as the major compounds in the aqueous and methanolic extracts, respectively. Both extracts exhibited remarkable antioxidant activity with IC₅₀ values of 1.47 ± 0.08 and 1.97 ± 0.15 mg/mL (DPPH), EC₅₀ = 3.682 ± 0.123 and 12.415 ± 0.344 mg/mL (RP), TAC values of 6.486 ± 0.275 and 5.323 ± 0.826 mg AAE/g, and β-carotene values of 56 ± 0.553 % and 50 ± 0.645 % respectively. Moreover, the aqueous extract showed the highest antibacterial activity against <em>Staphylococcus aureus</em> with a MIC value of 0.625 mg/mL, and an inhibition zone diameter of 11.5 ± 0.71 mm. The combined analysis of docking results and DFT calculations for various phenolic compounds against <em>Staphylococcus aureus</em> (Glycyl-penicillin-binding protein 2a) and <em>Escherichia coli</em> (DNA Gyrase B) revealed significant interactions and reactivities.</div></div><div><h3>Conclusion</h3><div>These results clearly indicate that PAK contains a high concentration of bioactive compounds, especially tocopherol and resveratrol, and may serve in the treatment of various diseases thanks to its extracts' promising antioxidant and antimicrobial activities.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102421"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in sperm quality with an antioxidant formula in mild-moderate male infertility: A prospective study","authors":"Carolyn Ee ,&nbsp;Jennifer Hunter ,&nbsp;Alan Bensoussan ,&nbsp;William Ledger ,&nbsp;Andrew Davidson ,&nbsp;Paul Fahey ,&nbsp;Christopher Nicol ,&nbsp;Harleen Kaur ,&nbsp;Mitchell Low ,&nbsp;Kate Templeman ,&nbsp;Mahmoud A. Al-Dabbas ,&nbsp;Caroline Smith","doi":"10.1016/j.eujim.2024.102412","DOIUrl":"10.1016/j.eujim.2024.102412","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to examine for an association between an antioxidant formula and sperm quality, as well as safety, in males with mild to moderate sub-fertility.</div></div><div><h3>Methods</h3><div>A prospective, open-label single-arm study examined the association between 24 weeks treatment with a proprietary formula containing 15 vitamins, minerals and antioxidants (including L-carnitine, acetyl-L-carnitine, selenium, folic acid, L-cysteine and Co-enzyme Q10) and sperm quality in healthy males aged 20 – 60 with idiopathic teratospermia, asthenospermia and/or mild-moderate oligospermia. The primary outcome was simultaneous change in sperm concentration, progressive motility and morphology between screening, week 16 and week 24. Secondary outcomes included safety, pregnancy rates, sperm oxidative stress, sperm DNA fragmentation, and serum/plasma nutrient levels.</div></div><div><h3>Results</h3><div>Sixty-one participants, with a mean age of 35.8 years, were included in the intention-to-treat analysis. No improvement in overall sperm quality was observed (i.e. simultaneous improvement in all three measures) as only two of the three sperm quality measures improved. Mean sperm concentration decreased by 0.24 standard deviations (SD) while mean morphology and motility improved by 0.28 and 0.04 SD respectively, however, these changes did not reach clinical significance (set at ≥ 0.4 SD improvement in means). There were no changes in secondary outcomes apart from an increase in homocysteine and vitamin B12 levels and decrease in high DNA stainability. Fifteen pregnancies were reported (pregnancy rate 29 %). Twenty-one of 62 (33.8 %) participants reported 36 adverse events (AEs), one of which was serious, leading to study withdrawal. Most AEs were of mild intensity and resolved.</div></div><div><h3>Conclusion</h3><div>Twenty-four weeks of an antioxidant formula was not associated with clinically significant changes in overall sperm quality. The formula was generally safe and well tolerated. Our findings are limited by the single- arm design, and randomised controlled trials are required to confirm or refute our findings.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102412"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of clinical control and symptom severity on attitudes towards holistic complementary alternative medicine in individuals with chronic obstructive pulmonary disease: A cross-sectional study","authors":"Züleyha Kılıç,&nbsp;Rabiye Çırpan","doi":"10.1016/j.eujim.2024.102415","DOIUrl":"10.1016/j.eujim.2024.102415","url":null,"abstract":"<div><h3>Introduction</h3><div>Many symptoms such as dyspnoea, chronic cough, chronic expectoration experienced in chronic obstructive pulmonary disease (COPD) and the progressive course of the disease negatively affect individuals bio-psychosocially and reduce their quality of life. At this point, it is believed to be important to use pharmacological and evidence-based complementary alternative medicine (CAM) methods together for effective disease management in COPD. The purpose of this study was to investigate the effect of clinical control and symptom severity on attitudes towards holistic, complementary, and alternative medicine in individuals with COPD.</div></div><div><h3>Methods</h3><div>This descriptive and correlational study was conducted with 150 hospitalised individuals with COPD that met the inclusion criteria for the study. A questionnaire form, the Modified Medical Research Council Dyspnoea Scale (mMRC), the Clinical COPD Questionnaire (CCQ), COPD Assessment Test (CAT), and the Holistic Complementary and Alternative Medicine Questionnaire (HCAMQ) were used to collect the data.</div></div><div><h3>Results</h3><div>In the study, 38% of the individuals with COPD used CAM, and herbal methods were the most preferred. The mean HCAMQ score was 28.24 ± 5.88. There was a statistically significant positive correlation between HCAMQ and mMRC and Clinical COPD Questionnaire functional status scores (p &lt; 0.05). An increase of one unit in the mMRC scores was correlated with an increase in HCAMQ scores of 1.125 points (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The present study determined that individuals with COPD had a positive attitude towards CAM, and the positive attitude towards CAM decreased with increasing dyspnoea level and decreasing COPD functional status control.</div></div><div><h3>Funding</h3><div>None</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102415"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving research methodologies are shaping the future of integrative medicine","authors":"Jennifer Hunter ,&nbsp;Guo-Yan Yang ,&nbsp;Nicola Robinson","doi":"10.1016/j.eujim.2024.102420","DOIUrl":"10.1016/j.eujim.2024.102420","url":null,"abstract":"","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102420"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hotspots and trends in global antiviral herbal basic research: A visualization analysis","authors":"Liangyu Hu,&nbsp;Chunying Wang,&nbsp;Yang Zhang","doi":"10.1016/j.eujim.2024.102419","DOIUrl":"10.1016/j.eujim.2024.102419","url":null,"abstract":"<div><div>Introduction: Viral infections can become public health emergencies due to the possibility of the wide transmission of their associated pathogens and their rapid variation. Moreover, most viruses lack effective therapeutic drugs and vaccines. Herbal medicines have been clinically validated for their broad-spectrum antiviral properties and their ability to leverage their complex compositions to target multiple levels, pathways, and channels. In this study, we seek to assess the current global research landscape and identify current and future directions for research on antiviral herbal medicines to guide future pharmacological developments. Methods: Bibliometric and visualization methods were used to analyze 2134 Chinese-language and 4600 English-language journal articles published between 2017 and 2022 from both Chinese and international databases, and the theme words and foci of highly cited papers were analyzed. Results: It was found that coronaviruses (especially severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), the influenza virus, the hepatitis B virus, and the human immunodeficiency virus were the primary targets for antiviral herbal medicines. Key herbs included <em>Glycyrrhiza glabra, Lonicera japonica, Scutellaria baicalensis, Ephedra sinica, Forsythia suspensa, Agastache rugosa, Astragalus membranaceus</em>, and <em>Poria cocos</em>. The primary active compounds known to be responsible for these antiviral effects are alkaloids, bioflavonoids, flavonoids, sterols, and polyphenols, including curcumin, quercetin, kaempferol, wogonin, stigmasterol, β-glutosterol, luteolin, coumarins, naringenin, gallic acid, berberine, and andrographolide. These compounds work through mechanisms such as inhibiting viral replication, blocking virus–receptor interactions, destroying viruses, regulating the immune response, oxidative stress induction, and cytokine response suppression. Conclusions: The research foci included the pharmacodynamic foundations, molecular dynamics simulation, and virtual screening of active components in herbs use for the treatment of viral diseases such as SARS-CoV-2 using bioinformatics, macromolecular docking, and network pharmacology. Significant gaps remain in interdisciplinary collaboration, especially regarding herb cultivation, processing, sustainable harvesting, and potential drug interactions.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102419"},"PeriodicalIF":1.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of Qianjinweijing decoction in the treatment of bronchiectasis: A systematic review and meta-analysis","authors":"Limin Zhang,&nbsp;Jin Su,&nbsp;Xiaozheng Wu,&nbsp;Wen Li,&nbsp;Yunzhi Chen","doi":"10.1016/j.eujim.2024.102418","DOIUrl":"10.1016/j.eujim.2024.102418","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Bronchiectasis is a chronic inflammatory airway disease marked by permanent dilation of the bronchi, recurrent infections, and associated complications. The traditional Chinese medicine Qianjinweijing Decoction (QJWJ) has shown promising results in bronchiectasis treatment with few side effects. However, there is a lack of recent comprehensive research evaluating its effectiveness. This review aims to examine the effectiveness and safety of QJWJ in treating bronchiectasis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We searched 7 databases including China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Chinese Science Database, China Biology Medicine Disc (Sinomed), PubMed, Embase, and Cochrane Library, for relevant randomized controlled trials (RCTs) until May 2023, in both Chinese and English. Two researchers conducted a comprehensive review of literature, extracting data based on predefined criteria. The risk of bias was assessed using the Cochrane Collaboration tool, and meta-analysis was performed using RevMan 5.4.1 and RStudio software. Quality of evidence was evaluated using GRADEpro (V3.6.) software.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;This review analysed 35 studies with 2609 patients. The QJWJ group consisted of 1318 patients, while the routine pharmacotherapy (RP) group had 1291 patients. Combining QJWJ and RP in bronchiectasis treatment showed better with clinical effectiveness [risk ratio (RR)=1.17, 95 % confidence interval (CI) (1.13, 1.21), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], the percentage of forced expiratory volume in the first second to the predicted value (FEV&lt;sub&gt;1&lt;/sub&gt; %) [mean difference (MD)=3.52, 95 % CI (1.48, 5.55), &lt;em&gt;P&lt;/em&gt; = 0.0007], the ratio of forced expiratory volume to forced vital capacity in the first second (FEV&lt;sub&gt;1&lt;/sub&gt;/FVC) [MD=6.62, 95 % CI (1.52, 11.72), &lt;em&gt;P&lt;/em&gt; = 0.01], peak expiratory flow rate (PEFR) [MD=7.14, 95 % CI (5.15, 9.12), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], white blood cell count (WBC) [MD=-1.42, 95 % CI (-2.53, -0.31), &lt;em&gt;P&lt;/em&gt; = 0.01], c-reactive protein (CRP) [MD=-7.2, 95 % CI (-9.3, -5.1), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], and the procalcitonin (PCT) [standardized mean difference (SMD)=-1.39, 95 % CI (-2.02, -0.76), &lt;em&gt;P&lt;/em&gt; &lt; 0.0001], without increasing the incidence of adverse reactions [RR=0.79, 95 % CI (0.44, 1.42), &lt;em&gt;P&lt;/em&gt; = 0.43]. QJWJ alone also significantly improved bronchiectasis treatment, enhanced clinical effectiveness [RR=1.19, 95 % CI (1.04, 1.36), &lt;em&gt;P&lt;/em&gt; = 0.010], FEV&lt;sub&gt;1&lt;/sub&gt; % [MD=7.09, 95 % CI (4.5, 9.68), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], and reduced WBC [MD=-2.7, 95 % CI (-3.7, -1.7), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], CRP [MD=-4.22, 95 % CI (-55.32, -3.12), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], without increasing the incidence of adverse reactions [RR=0.20, 95 % CI (0.01, 4.06), &lt;em&gt;P&lt;/em&gt; = 0.29].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Evidence suggested that QJWJ, used alone or with RP, notably improved bronchiectasis treatment outcomes, enhanced lung fun","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102418"},"PeriodicalIF":1.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflexology specific guidance for using the template for the intervention description and replication (TIDieR): A delphi study","authors":"Jacqueline James ,&nbsp;Joseph T. Costello ,&nbsp;Sally Edwards-Price ,&nbsp;Tracey Smith ,&nbsp;Amanda McAuley ,&nbsp;Barbara E. Scott ,&nbsp;Spyridon Dimitrakoulas ,&nbsp;Marcia Edwards ,&nbsp;Dorothy Kelly ,&nbsp;David L. Wayte ,&nbsp;Andrea F. Porritt ,&nbsp;Amy K. Drahota","doi":"10.1016/j.eujim.2024.102416","DOIUrl":"10.1016/j.eujim.2024.102416","url":null,"abstract":"<div><h3>Introduction</h3><div>Reflexology is a holistic, complementary therapy, carried out on the feet, hands, ears, or face. There is no single accepted definition of reflexology, as it encompasses various practices, making it important that research studies articulate exactly what the reflexology intervention entailed.</div><div>This study sought to produce reflexology-specific guidance for researchers and practitioners, for use with the Template for the Intervention Description and Replication (TIDieR) checklist, to improve the quality of the documentation of reflexology interventions within the research literature.</div></div><div><h3>Method</h3><div>This study used the TIDieR checklist as a framework for a three-round Delphi process to gain agreement on what information authors should consider including in their study report to support replication of their intervention. Following the Delphi process two online consolidation meetings were held to agree the wording and examples for the guidance document.</div></div><div><h3>Results</h3><div>Guidance based on the unique considerations of reflexology interventions was developed for use with the TIDieR checklist.</div><div>A diverse group of 43 experts from Europe, North America, Asia, and Australasia, including 40 reflexologists, 9 of whom were also study authors, and 2 methodological specialists contributed to the guidance.</div><div>Each Delphi round was completed by 39 to 42 (91 % to 98 %) of the 43 panel members, and 16 (37 %) participated in the consolidation meetings. Consensus was reached on 46 items via the Delphi rounds (36 to be included in the guidance and 10 to be excluded); 38 items failed to reach consensus. The consolidation meetings informed the final wording of the guidance document, covering all the 12 TIDieR domains.</div></div><div><h3>Conclusion</h3><div>The reflexology-specific guidance strongly advocates for the utilisation of the TIDieR checklist, with elaboration tailored for reflexology as used in various contexts internationally. By serving as a reporting guide for reflexology intervention studies, this tool has the capacity to improve the reporting of reflexology intervention studies, thereby facilitating replicability and promoting greater transparency within the field of reflexology.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102416"},"PeriodicalIF":1.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurveda interventions for non-specific chronic low back pain— protocol for a systematic review and network meta-analysis","authors":"Ritu Kumari,&nbsp;Mandip Goyal,&nbsp;Kalpesh Panara","doi":"10.1016/j.eujim.2024.102413","DOIUrl":"10.1016/j.eujim.2024.102413","url":null,"abstract":"<div><h3>Introduction</h3><div>Low back pain (570 million prevalent cases worldwide) is the main contributor to the overall burden of musculoskeletal conditions. The most common form of low back pain is non-specific low back pain (NSCLBP) (almost 90 %). There are no treatments that completely cure chronic low back pain. Ayurveda is one of the traditional systems of Indian medicine commonly practiced in Southeast Asian countries. Even though Ayurveda interventions (oral medication or procedure-based treatment or combined therapy) are practiced widely for this condition, there is ambiguity about the hierarchy of treatment. The present review has been planned to compare all the available Ayurveda treatment modalities for NSCLBP in terms of efficacy, and safety, in all the age groups of patients.</div></div><div><h3>Methods</h3><div>This review will be written in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the PRISMA extension for network meta-analyses. Electronic searches will be carried out in PubMed, Scopus, TRIP, Website of Indexing of Indian Medical Journals, the Cochrane Register for Controlled Trials, The Clinical Trials Registry- India, AYUSH research portal, and Digital Helpline for Ayurveda Research Articles, and other pre-print repositories since its inception till 31st March 2024. Randomized controlled trials, randomized cross-over studies, cluster-randomized studies, and nonrandomized studies of interventions (prospective cohort studies, non-randomized clinical trials) will be included. The risk of bias will be assessed with ROB-2, ROBINS-I, and other revised risk of bias tools for cross-over studies and cluster randomised studies recommended by the Cochrane collaboration. To evaluate the credibility of the findings, the Grading of Recommendations Assessment, Development, and Evaluation method for network meta-analysis will be implemented. A narrative approach to synthesize and report qualitative and quantitative data will be used, and where feasible, we will conduct network meta-analyses using STATA software.</div></div><div><h3>Conclusions</h3><div>This protocol defines a plan of the study that would facilitate the process of recommending treatment for NSCLBP, by providing a treatment hierarchy of Ayurvedic treatment to the policymakers and stakeholders.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102413"},"PeriodicalIF":1.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}