European Journal of Integrative Medicine最新文献

{"title":"Is chiropractic spinal manipulation effective for the treatment of cervicogenic, tension-type, or migraine headaches? A systematic review","authors":"Luis Ceballos-Laita ,&nbsp;Edzard Ernst ,&nbsp;Andoni Carrasco-Uribarren ,&nbsp;Daniel García-García ,&nbsp;Sandra Jiménez-del-Barrio","doi":"10.1016/j.eujim.2025.102462","DOIUrl":"10.1016/j.eujim.2025.102462","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with headaches often seek complementary and alternative therapies, including chiropractic care. Chiropractic spinal manipulation is one of the most commonly used techniques for these patients; however, its effectiveness remains unclear. This systematic review aimed to evaluate the effectiveness of chiropractic spinal manipulation in reducing headache days, episode duration, episode intensity, and medication intake in patients with headaches.</div></div><div><h3>Methods</h3><div>MEDLINE (Pubmed), PEDro, SCOPUS, Cochrane Library and Web of Science databases were searched from inception to April 2024. PICO search strategy was used to identify randomized controlled trials applying chiropractic spinal manipulations versus sham manipulation, no additional intervention, or other conservative non-pharmacological interventions in patients with headaches. Eligible studies and data extraction were conducted independently by two reviewers. Quality of the studies was assessed with Physiotherapy Evidence Database scale, and risk of bias with Cochrane Collaboration tool. Certainty of the evidence was evaluated using GRADE approach.</div></div><div><h3>Results</h3><div>Eight studies ranging from low to high methodological quality were included in the synthesis without a meta-analysis. The results were categorized into three subgroups: chiropractic manipulation versus sham, chiropractic manipulation versus control, and chiropractic manipulation versus deep friction massage. Among the five studies comparing chiropractic manipulation to sham, two found a significant reduction in the number of headache days. Of the three studies comparing chiropractic manipulation to a control, one reported a decrease in headache episode duration. No significant differences were observed for any other variable across the subgroups. The certainty of evidence was downgraded to very low.</div></div><div><h3>Conclusions</h3><div>It is uncertain if chiropractic spinal manipulation is more effective than sham, control, or deep friction massage interventions for patients with headaches.</div></div><div><h3>PROSPERO registration number</h3><div>CRD42024518480</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102462"},"PeriodicalIF":1.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the sedation effect of music intervention and remimazolam in elderly patients undergoing transurethral prostate resection under spinal anesthesia: A randomized controlled clinical trial","authors":"Jing Wu ,&nbsp;Sen Cai ,&nbsp;Chang-Ming Wang ,&nbsp;Xue-Song Wang","doi":"10.1016/j.eujim.2025.102455","DOIUrl":"10.1016/j.eujim.2025.102455","url":null,"abstract":"<div><h3>Introduction</h3><div>Pharmacological and non-pharmacological interventions are widely utilized in clinical practice for intraoperative sedation. However, the degree of sedation and side effects vary between the two modalities. This study aimed to explore the sedation effect of music intervention and remimazolam in elderly patients undergoing transurethral prostate resection (TURP) under spinal anesthesia.</div></div><div><h3>Methods</h3><div>Patients aged 60–80 years, scheduled for TURP under spinal anesthesia, were prospectively enrolled in this study and randomly assigned to no music group (Group A), music intervention group (Group B), remimazolam group (Group C), and remimazolam-combined-music intervention group (Group D). The primary outcome was assessed using the bispectral index (BIS). Secondary outcomes included blood pressure, heart rate (HR), pulse oxygen saturation (SpO₂), cognitive function, the incidence of adverse events including body movement and coughing, and respiratory depression, as well as surgeon and patient satisfaction.</div></div><div><h3>Results</h3><div>The study randomly assigned 120 patients to four groups, with 117 patients ultimately included in the analysis. At specific time points, BIS values for Groups B [T7: 20 min after the start of TURP, T11: 60 min after the start of TURP and T14: leaving the operating room(OR)], C (T3–14: immediately after changing to lithotomy position to leaving the OR), and D (T3–14) were lower than those for Group A (<em>P</em> &lt; 0.05). Compared to Group A, significant decreases in blood pressure and SpO₂ were observed after intervention in Groups C and D, respectively (<em>P</em> &lt; 0.05). Although the incidence of adverse events, including body movement and coughing, was higher in Groups C and D compared to Group A (<em>P</em> &lt; 0.05), there was no significant difference in the incidence of respiratory depression. Significantly, surgeons reported lower satisfaction in Group C compared to Group A (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>While remimazolam induced deeper sedation, music intervention offered only a slight sedative effect. However, remimazolam also increased the incidence of body movement and coughing, which potentially reduced surgeon satisfaction.</div></div><div><h3>Clinical trial registration</h3><div>ChiCTR2300071284</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102455"},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloodletting therapy to manage fever caused by infectious diseases: A systematic review of randomized controlled trials","authors":"Shuai Dong ,&nbsp;Meng-Fang Xu ,&nbsp;Xin-Hao Li ,&nbsp;Ye-Xin Zhang ,&nbsp;Nicola Robinson ,&nbsp;Xin-Xin Yang ,&nbsp;Hui-Juan Cao","doi":"10.1016/j.eujim.2025.102441","DOIUrl":"10.1016/j.eujim.2025.102441","url":null,"abstract":"<div><h3>Introduction</h3><div>Bloodletting therapy (BLT), a traditional Chinese medicine (TCM) non-pharmaceutical therapy, may have a good antipyretic effect, but the evidence has not been evaluated. The aim of this systematic review was to assess the antipyretic effect and safety of TCM BLT used in patients with infections.</div></div><div><h3>Methods</h3><div>The protocol of this review was registered in PROSPERO (No.CRD42023411059). We included randomized controlled trials (RCTs) comparing BLT alone or in combination with another therapy to controls (no treatment or usual care). A search of CNKI, Wanfang, VIP, Sinomed, Cochrane Library, PubMed, and Embase databases was conducted up to March 2023. Cochrane Risk of Bias 2.0 tool and GRADE were used for assessing methodological quality of included trials and certainty of evidence.</div></div><div><h3>Result</h3><div>Fourteen RCTs (1419 participants) were included. BLT (either used alone or as add on therapy) was superior to drugs alone in increasing antipyretic rate and lowering the body temperature only for adults. For children or when combined with pediatric Tuina or herbal medicine, its advantages were not shown. The fever clearance time may be shortened (Mean Difference (MD)=-7.59 h, 95 %CI -12.73 h to -2.44 h, 194 participants, <em>I²</em>=69 %, 3 trials, <em>P</em> <em>=</em> 0.004) and the commencement of fever abatement (MD=-1.48 h, 95 %CI -2.02 h to -0.94 h, 134 participants, <em>I²</em>=0 %, 2 trials, <em>P</em> &lt; 0.00001) improved when used as an adjunctive treatment with pediatric Tuina. Safety of BLT to treat fever was still unclear since few trials reported this relevant outcome. Certainty of evidence was very low.</div></div><div><h3>Conclusion</h3><div>The long-term (24hrs+) antipyretic effect of BLT alone and combined with drugs may be better than that of drugs alone for adults. For children combining BLT and pediatric Tuina/herbal medicine was no better in increasing antipyretic rate compared to pediatric Tuina/herbal medicine alone. Current evidence does not provide firm conclusions about the safety of BLT.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102441"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvia miltiorrhiza in angina pectoris and myocardial infarction: A bibliometric analysis","authors":"Qi Lan ,&nbsp;Jin-Wen Wu ,&nbsp;Ding-Shan Zhang ,&nbsp;Yu-Mei Qian ,&nbsp;Xin-Rui Yang ,&nbsp;Ting Peng ,&nbsp;Zhen-Xun Wan ,&nbsp;Ping Liu ,&nbsp;Yan Jiang ,&nbsp;Meng-Nan Liu","doi":"10.1016/j.eujim.2025.102445","DOIUrl":"10.1016/j.eujim.2025.102445","url":null,"abstract":"<div><h3>Introduction</h3><div>Angina pectoris and myocardial infarction, as the common causes and symptoms of cardiovascular disease, are one of the important research fields of traditional and complementary medicine. Using bibliometric methods, this study conducted a multidimensional analysis of the research trajectory of Salvia miltiorrhiza in the treatment of angina pectoris and myocardial infarction from 2007 to 2024, with a focus on its research characteristics, hot spots and frontiers.</div></div><div><h3>Methods</h3><div>Title, topic, abstract and author keywords related to Salvia miltiorrhiza, myocardial infarction and angina pectoris were utilized in the Web of Science Core Collection database to maximize the search related to the research topic. Co-authorship, co-occurrence and co-citation analysis of publications, countries, institutions, journals, authors, references and keywords were conducted using Citespace 6.3.R1, SCImago Graphica Beta 1.0.42, VOSviewer, Bibliometrix R Package and Microsoft Excel.</div></div><div><h3>Results</h3><div>The annual publication volume of studies related to the treatment of angina pectoris and myocardial infarction using Salvia miltiorrhiza exhibits phased changes, demonstrating a general upward trend. China is the country with the highest number of publications and citations, and it has established collaborations with multiple countries. Canada and India have emerged as significant participants in recent years. The number of authors and publications meets the requirements of Price's Law and the core author in this research field is Li, Xiang. The top three keywords are Salvia miltiorrhiza (75 occurrences), myocardial infarction (70 occurrences) and Danshen(37 occurrences).</div></div><div><h3>Conclusions</h3><div>The current hotspots of Salvia miltiorrhiza in the treatment of angina pectoris and myocardial infarction mainly focus on three aspects: the pharmacological effects of this herb and its active ingredients, the treatment mechanism of angina pectoris and myocardial infarction, and the physiological and pathological relationship of its network pharmacology. These findings not only provide a solid foundation for the clinical application of Salvia miltiorrhiza but also demonstrate its potential in preventing and controlling cardiovascular diseases.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102445"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary and integrative health approaches used for pain management by U.S. adults with chronic fatigue syndrome/myalgic encephalomyelitis: Findings from the 2022 National Health Interview Survey","authors":"Jenna L. Adamowicz ,&nbsp;Zoe Sirotiak ,&nbsp;Emily B.K. Thomas ,&nbsp;Brian C. Lund ,&nbsp;Katherine Hadlandsmyth ,&nbsp;Mary A. Driscoll","doi":"10.1016/j.eujim.2025.102443","DOIUrl":"10.1016/j.eujim.2025.102443","url":null,"abstract":"<div><h3>Introduction</h3><div>While most persons with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) experience pain, traditional pain treatments may be harmful or unfavorable to this population. Complementary and integrative health approaches for pain management offer a potentially important alternative. However, there is a paucity of research regarding which pain treatments patients with CFS/ME use. This study examined the prevalence of pain-related complementary and integrative health usage in CFS/ME adults and the factors that may be associated with usage, such as sex and anxious and depressive symptoms.</div></div><div><h3>Methods</h3><div>Using 2022 U.S. National Health Interview Survey data, seven different complementary and integrative health approaches were examined. Survey weights and variance estimation variables were utilized, and Rao-Scott chi-square test examined group-based differences.</div></div><div><h3>Results</h3><div>A total of 453 individuals (1.6 %) reported currently having CFS/ME. About one third (32.3 %) of the CFS/ME sample reported using complementary and integrative health approaches for pain management. The most commonly reported treatments were meditation (15.1 %), chiropractic care (14.5 %), and massage (10.7 %). Females with CFS/ME were significantly more likely to use pain-related complementary and integrative health approaches relative to their male counterparts (39.1 % vs. 24.3 %, respectively; χ² (1) = 5.90, <em>p</em> = 0.015). Usage of pain-related complementary and integrative health approaches did not differ significantly among those with or without clinically elevated anxious or depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Overall, persons with CFS/ME appear to use pain-related complementary and integrative health modalities at a lower rate relative to the general population. Although complementary and integrative health use was common, over half of the sample were not using these modalities, highlighting an opportunity for broader dissemination for pain management purposes.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102443"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into add-on effectiveness of Chinese herbal formulae in COVID-19: An overview of systematic reviews","authors":"Bo Li ,&nbsp;Yi-Ying Wang ,&nbsp;Le-yan Hu ,&nbsp;Jie Lian ,&nbsp;Shuai Dong ,&nbsp;Guo-dong Li ,&nbsp;Jia-xin Wang ,&nbsp;Zheng Li ,&nbsp;Hui-juan Cao","doi":"10.1016/j.eujim.2025.102440","DOIUrl":"10.1016/j.eujim.2025.102440","url":null,"abstract":"<div><h3>Introduction</h3><div>Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, overwhelming healthcare systems. Numerous clinical trials have explored the efficacy of Chinese herbal formulae (CHFs) in treating COVID-19, resulting in a surge of systematic reviews (SRs). This review critically evaluates the additive effectiveness of CHFs for COVID-19, aiming to provide a robust foundation for high-quality research and integrated therapeutic strategies.</div></div><div><h3>Methods</h3><div>This PRISMA-compliant review was registered on PROSPERO. We included SRs assessed oral CHFs combined with guideline recommended Standard Treatment (ST), versus ST in patients with COVID-19 patients. Primary outcomes included clinical improvement (e.g., days without ventilator support) and deterioration (e.g., new need for oxygen therapy). PubMed, Cochrane Library, Embase, Sinomed, CNKI, Wanfang, and VIP were searched from inception to July 1, 2024, for SRs (Cochrane/non-Cochrane) of RCTs reporting predefined outcomes. Secondary meta-analyses were conducted using RevMan 5.3, with methodological quality and evidence certainty assessed via AMSTAR-II and GRADE.</div></div><div><h3>Results</h3><div>Eight SRs (6860 cases) were included. Meta-analyses showed that CHF combined with ST outperformed ST alone in reducing all-cause mortality (RR = 0.27, 95 %CI [0.08–0.96], <em>P</em> = 0.04), adverse events (RR = 0.34, 95 %CI [0.20–0.59], <em>P</em> &lt; 0.0001), severe case conversion (RR = 0.33, 95 %CI [0.17–0.66], <em>P</em> = 0.002), and improving pulmonary imaging (RR = 1.28, 95 %CI [1.12–1.46], <em>P</em> = 0.0003). No significant differences were observed in clinical symptom recovery rates (cough) or recovery times (cough and fatigue). Bubble plots suggested weak to moderate effects of specific CHFs (e.g., <em>Buzhongyiqi Decoction, Maxingshigan-Weijing Decoction</em>) on viral clearance, severe case conversion, adverse events, and pulmonary imaging.</div></div><div><h3>Conclusion</h3><div>Comprehensive analyses indicated that CHFs showed good add-on effect in treating COVID-19. However, it is important to note that the overall quality of evidence in these studies is generally low, and further high-quality clinical trials are needed to validate these findings.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102440"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of the results of Reiki research","authors":"Melike Demir Doğan","doi":"10.1016/j.eujim.2025.102442","DOIUrl":"10.1016/j.eujim.2025.102442","url":null,"abstract":"<div><h3>Introduction</h3><div>This study analyses bibliometric indicators to assess global research trends on Reiki, including publication patterns and key contributing countries.</div></div><div><h3>Methods</h3><div>The publications included in Web of Science (WOS) databases between 1970 and 2024 were reviewed. The WOS database was searched using TS= “REIKI” and all WOS indexes were included. This search identified 414 studies. Among them, letters (<em>n</em> = 7), editorial materials (<em>n</em> = 19), book reviews (<em>n</em> = 9), corrections (<em>n</em> = 2), art and poetry (<em>n</em> = 1), news (<em>n</em> = 1), and retracted publications (<em>n</em> = 1) were removed. The remaining 374 articles were included in this bibliometric analysis. The R-package for bibliometric analysis (Bibliometrix) was used.</div></div><div><h3>Results</h3><div>The bibliometric analysis found that researchers published Reiki-related studies between 1983 and 2024, with a publication growth rate of 4.47 %. On average, articles were 9.5 years old and received 13 citations per document. The total number of keywords identified by the authors was 553, the number of authors in the articles was 1124 authors, the number of single-author articles was 70, the average number of publications per author was 3.5, and international co-authorships were 7.219 %. The USA, Brazil, the United Kingdom, Canada, and Turkiye were the top five countries that published on Reiki, respectively. The USA, Canada, the United Kingdom, Australia, and Turkiye were the top five countries with the most cited articles, respectively. Vitale A. is the most cited author. Journal of Alternative and Complementary Medicine is the most cited journal.</div></div><div><h3>Conclusion</h3><div>This study is the first of its kind to evaluate the articles written by researchers in the field of Reiki only. Despite the difficulties researchers experienced in the field of Reiki, the studies have increasingly been conducted in this field over the years and have been cited studies more. This study may be helpful for researchers to determine productive countries, journals, authors, and emerging trends in Reiki by providing comprehensive analyses and structured information on this subject.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102442"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical characterization of phenolic compounds by liquid chromatography-time of flight mass spectrometry and biological activities of Peltigera neckeri, Peltigera canina and Peltigera ponojensis from Türkiye","authors":"Burcu Sümer Tüzün ,&nbsp;Seyhan Oran ,&nbsp;Şule Öztürk ,&nbsp;Tuğçe Fafal ,&nbsp;Recep İlhan ,&nbsp;Bijen Kıvçak","doi":"10.1016/j.eujim.2025.102444","DOIUrl":"10.1016/j.eujim.2025.102444","url":null,"abstract":"<div><h3>Introduction</h3><div>Lichens are symbiotic associations that live in diverse environmental conditions. They produce metabolites such as carotenoids, lichen phenolics, and water-soluble phenolics. The study aims to determine the content and <em>in-vitro biological activities</em> of <em>Peltigera</em> lichens from Bursa province, which have not been previously investigated.</div></div><div><h3>Methods</h3><div>Methanol and acetone extracts were analyzed. Liquid Chromatography-Time of Flight Mass Spectrometry (LC/QTOF/MS) was used for qualitative and quantitative analysis. <em>In-vitro</em> antioxidant and tyrosinase inhibitory activities were evaluated, along with cytotoxic activity assessments.</div></div><div><h3>Results</h3><div>Zeaxanthin was identified in the acetone extract of <em>P. neckeri</em>. Vanillic acid was found to be the major component in both <em>P. canina</em> extracts, while neoxanthin was detected in the methanol extract. Evernic acid and usnic acid were also present in both extracts. Rosmarinic acid, rutin, and zeaxanthin were not detected in <em>P. ponojensis</em> extracts, whereas neoxanthin, usnic acid, and evernic acid were present. The most active extract was the methanol extract of <em>P. ponojensis</em>, with an IC₅₀ value of 23.52 ± 0.02 µg/mL for radical scavenging. No tyrosinase inhibitory activity was observed in either extract of <em>P. neckeri</em>. The most active extract was methanol extract of <em>P. ponojensis</em> with an IC₅₀ value of 30.588 ± 0.02 µg/mL. Cytotoxicity results showed no death or proliferation reduction in any tested cell lines.</div></div><div><h3>Conclusion</h3><div><em>Peltigera</em> species may serve as potential sources of antioxidants.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102444"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herb-derived compounds from Radix Salviae decoction (RSD) modulated cell death of vascular smooth muscle cells","authors":"Peizhong Liu ,&nbsp;Qingqing Liu ,&nbsp;Guofu Zhong ,&nbsp;Shunzi Zhangyun ,&nbsp;Chuangpeng Li ,&nbsp;Dawei Wang ,&nbsp;Qing Liu","doi":"10.1016/j.eujim.2025.102447","DOIUrl":"10.1016/j.eujim.2025.102447","url":null,"abstract":"<div><h3>Introduction</h3><div>Prior research has suggested that herb-derived compounds from <em>Radix Salviae</em> decoction (RSD) may have anti-inflammatory, antioxidant, antithrombotic and cardiac function improvement properties in cardiovascular system diseases. However, the efficacy and mechanism of herb-derived compounds from RSD for modulating cell death of vascular smooth muscle cells (VSMC) have yet to be investigated. This study aimed to investigate the effects of RSD in modulating cell death of vascular smooth muscle cells and elucidate the underlying mechanisms.</div></div><div><h3>Methods</h3><div>Chemical constituents were analyzed through literature and databases. Network pharmacological analysis identified targets for herb-derived compounds from RSD and cell death. A protein-protein interaction network was constructed using String, followed by GO and KEGG analyses to explore pathways affecting vascular smooth muscle cell death.</div></div><div><h3>Results</h3><div>Network pharmacological analysis identified the targets for the three compounds from RSD (Tanshinone ⅡA (DST), Santalol (TXC), and Bornyl ester (LNZ)) and three kinds of cell death (pyroptosis, autophagy and apoptosis). Large nodes such as CASP8, CASP3, TP53, JUN and BAX were observed at the center of the targets network, suggesting that they play key roles in protein interaction networks. In serum-free medium (SFM) conditions of VSMC <em>in vitro</em>, treatment with the herb–derived compounds from RSD significantly promoted pyroptosis of VSMC indicated by increased mRNA levels of GSDMD and GSDME, and the increased mRNA levels of IL-1β. These compounds also inhibited autophagy, as they reduced the expression of ATG12, and decreased the LC3-II/I ratio in VSMC; and the compounds decreased the proportion of early apoptotic cells indicated by flow cytometry. Furthermore, cytokines of IL-6 and TNF-α were notably inhibited after treatment with these compounds. For the related cell signaling transduction, the herb-derived compounds from RSD suppressed PI3K-AKT while activating the NF-κB signaling pathway.</div></div><div><h3>Conclusion</h3><div>This study reveals that treatment of nutrition-depleted VSMC with DST, TXC, and LNZ leads to the promotion of pyroptosis and downregulation of inflammatory factor expression, alongside reduction of autophagy and early apoptotic cells.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102447"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of auricular acupressure on sexual functioning among postmenopausal women: A randomized sham controlled trial","authors":"Zainab Alimoradi ,&nbsp;Zohreh Hosseini Marznaki ,&nbsp;Mohammad Hossein Hakimi ,&nbsp;Terry Oleson ,&nbsp;Mark D. Griffiths","doi":"10.1016/j.eujim.2025.102451","DOIUrl":"10.1016/j.eujim.2025.102451","url":null,"abstract":"<div><h3>Introduction</h3><div>Sexual dysfunction is a common complaint of postmenopausal women. The present study investigated the effect of ear acupressure on sexual functioning (the primary outcome) and sexual distress (the secondary outcome) among postmenopausal women.</div></div><div><h3>Methods</h3><div>A randomized, sham-controlled triple-blinded trial was conducted from June 2022 to January 2023 among postmenopausal women recruited from urban comprehensive health centers in Qazvin, Iran. Ninety postmenopausal women were randomly assigned (1:1) to auricular acupressure or sham control group using a balanced block randomization method. The intervention was 10 sessions of ear acupressure (at four-day intervals) using adhesives containing vaccaria seeds. The sham intervention was identical except for the use of special non-latex adhesives but without the vaccaria seeds. The Female Sexual Function Index (FSFI), Arizona Sexual Experience Scale (ASEX), and Female Sexual Distress Scale (FSDS) were completed by participants three times during the study: before intervention, one month after intervention, and two months after intervention.</div></div><div><h3>Results</h3><div>Auricular acupressure significantly increased the mean score on the FSFI in the intervention group compared to the sham group (adjusted mean difference of 5.12 [95 % CI: 3.39; 6.85] in first follow-up, and 10.17 [95 % CI: 7.71; 12.63]) in second follow-up. There was a significant decrease in the mean score on the ASEX (decreased scores indicate better sexual experience) and FSD in the intervention group compared to the sham group in first and second follow-up. These changes were also clinically significant. No adverse events were reported during the intervention or the follow-ups.</div></div><div><h3>Conclusion</h3><div>Among postmenopausal women, auricular acupressure appears to be an effective intervention in improving sexual functioning, as well as reducing sexual distress.</div></div><div><h3>Trial registration</h3><div>The trial was registered prospectively in 2022–04–13 (code IRCT20180218038789N6) in the Clinical Trial Registration Center of Iran.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102451"},"PeriodicalIF":1.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}