European Journal of Integrative Medicine最新文献

{"title":"Add-on effects of five-animal exercise in ankylosing spondylitis: A randomized controlled trial","authors":"Lijun Pang ,&nbsp;Yunfei Li ,&nbsp;Lili Cheng ,&nbsp;Junjie Chen ,&nbsp;Ziheng Zhu ,&nbsp;Zhongfu Tang ,&nbsp;Chuanbing Huang","doi":"10.1016/j.eujim.2026.102613","DOIUrl":"10.1016/j.eujim.2026.102613","url":null,"abstract":"<div><h3>Introduction</h3><div>Ankylosing spondylitis (AS) is a chronic inflammatory spondyloarthritis in which pharmacologic therapy alone often leaves residual pain, stiffness and functional limitation. Wuqinxi (Five-Animal Exercise) is a traditional Chinese mind–body practice that may provide anti-inflammatory and mobility benefits. This trial evaluated the add-on effects of a 12-week Wuqinxi programme combined with standard pharmacologic therapy on clinical, biomarker and imaging outcomes in patients with AS.</div></div><div><h3>Methods</h3><div>In this single-centre, randomized, parallel-group trial, 64 adults with AS receiving stable celecoxib and sulfasalazine were allocated to Wuqinxi plus standard care or standard care alone for 12 weeks. The primary outcome was change in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Key secondary outcomes were Bath Ankylosing Spondylitis Functional and Metrology Indices (BASFI, BASMI), spinal pain (visual analogue scale), and radiographic and MRI scores (modified Stoke Ankylosing Spondylitis Spinal Score [mSASSS], Spondyloarthritis Research Consortium of Canada [SPARCC] sacroiliac joint score). Analyses followed the intention-to-treat principle and are reported as between-group mean differences in change with 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>BASDAI improved in both groups but more with Wuqinxi (mean change −2.6 vs −2.1; between-group difference −0.58, 95% CI −1.10 to −0.05). Add-on Wuqinxi yielded larger gains in physical function and spinal mobility (BASFI difference −1.35, 95% CI −1.93 to −0.78; BASMI difference −1.63, 95% CI −2.15 to −1.10), and greater reductions in spinal pain (visual analogue scale difference −0.94, 95% CI −1.56 to −0.32). Structural and inflammatory scores also favoured Wuqinxi (mSASSS difference −5.31, 95% CI −8.49 to −2.14; SPARCC difference −6.31, 95% CI −8.59 to −4.04), accompanied by consistent improvements in health-related quality of life, spinal mobility measures and inflammatory biomarkers. No serious adverse events occurred; mild musculoskeletal soreness and gastrointestinal discomfort were infrequent and self-limited in both groups.</div></div><div><h3>Conclusions</h3><div>A 12-week, partially supervised Wuqinxi programme as an add-on to standard pharmacologic therapy improved disease activity, function, spinal mobility, quality of life, inflammatory biomarkers and MRI inflammation in patients with AS, with good short-term safety. Larger and longer trials are needed to confirm durability and structural benefits.</div></div><div><h3>Trial registration</h3><div>ITMCTR2024000756.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102613"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of 4-7-8 breathing exercise training on sleep quality of undergraduate nursing students: A randomized controlled study","authors":"Uğur Doğan,&nbsp;Meltem Sungur","doi":"10.1016/j.eujim.2026.102620","DOIUrl":"10.1016/j.eujim.2026.102620","url":null,"abstract":"<div><h3>Introduction</h3><div>Undergraduate nursing students commonly experience poor sleep quality due to irregular sleep patterns, academic pressures, clinical stressors, and excessive caffeine intake, yet the efficacy of the 4–7–8 breathing exercise has not been studied in this population. This study examined the effects of a 4-week 4–7–8 breathing exercise intervention on sleep quality among undergraduate nursing students.</div></div><div><h3>Methods</h3><div>This randomized controlled trial examined the effects of a 4-week 4–7–8 breathing exercise intervention on sleep quality among undergraduate nursing students at a public university in south-eastern Turkey. Recruited participants were randomly allocated using computer-generated block randomization to either an intervention group (<em>n</em> = 40) that practiced the technique nightly or a control group (<em>n</em> = 42) that received no intervention. The 4–7–8 breathing technique involves inhaling through the nose for 4 s, holding the breath for 7 s, and exhaling through the mouth for 8 s. Sleep quality was assessed pre- and post-intervention using the Pittsburgh Sleep Quality Index (PSQI).</div></div><div><h3>Results</h3><div>The intervention and control groups, which showed similar baseline characteristics including mean age (21.1 ± 0.7 vs 21.5 ± 2.0 years) and gender distribution (77.5% vs 78.6% female), both demonstrated poor sleep quality at baseline (PSQI &gt; 5). Post-intervention, the intervention group showed significant improvements in total PSQI scores compared to the control group (mean difference:2.76; 95% CI:3.76 to -1.76). Significant between-group improvements were also found for the subscales of subjective sleep quality (mean difference: 0.51; 95% CI:0.78 to -0.24), sleep latency (mean difference: 0.54; 95% CI:0.91 to -0.18), sleep disturbances (mean difference: 0.47; 95% CI:0.71 to -0.22), and daytime dysfunction (mean difference: 0.91; 95% CI:1.25 to -0.56). The control group exhibited no significant changes excluding sleep disturbances. No adverse events were reported.</div></div><div><h3>Conclusions</h3><div>The 4–7–8 breathing exercise is an effective non-pharmacological intervention for improving sleep quality in undergraduate nursing students. These findings support its integrations into nursing education and clinical practice as a self-care tool and potential therapeutic modality for patients. Future research should explore long-term effects and applicability to other stressed populations.</div></div><div><h3>The clinical trial registration number</h3><div>NCT06103344 (<span><span>http://clinicaltrials.gov/</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102620"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the medicinal potential of Helianthus tuberosus: A comprehensive bibliometric study","authors":"Ramazon Safarzoda Sharoffidin ,&nbsp;Jabor Yusufi Salomiddin ,&nbsp;Shahriyor Bakhtiyor Sharifzoda ,&nbsp;Khushronsho Abdukarimzoda ,&nbsp;Afshin Zare ,&nbsp;Nadiar M. Mussin ,&nbsp;Kulyash R. Zhilisbayeva ,&nbsp;Nader Tanideh ,&nbsp;Amin Tamadon","doi":"10.1016/j.eujim.2025.102608","DOIUrl":"10.1016/j.eujim.2025.102608","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Helianthus tuberosus</em>, commonly known as Jerusalem artichoke, has been recognized for its diverse medicinal applications attributed to its rich composition of bioactive compounds. Despite the growing body of research, a comprehensive understanding of the publication landscape concerning its medicinal potential remains limited. This study aims to perform a detailed bibliometric analysis of the literature pertaining to the medicinal applications of <em>H. tuberosus</em>, elucidating publication characteristics, journal dissemination patterns, author and institutional productivity, country-specific research contributions, and prevalent thematic focuses.</div></div><div><h3>Methods</h3><div>A systematic search was conducted from January 1979 to February 2025 using the Web of Science and Scopus databases. The search strategy involved querying article titles, abstracts, and keywords with relevant terms related to <em>H. tuberosus</em> and its medicinal applications. No restrictions were placed on publication year, but only English-language articles were included. After removing duplicates and normalizing metadata, a refined dataset of 129 unique documents were analyzed. Bibliometric analysis was performed using the 'bibliometrix' package within the RStudio environment.</div></div><div><h3>Results</h3><div>The analysis encompassed 129 research articles, featuring 568 authors from 40 countries, covering a 45-year period. The annual progression of literature showed variability over time, with author activity peaking in 2021 and 2022, each year producing 18 and 16 publications, respectively. The top ten journals contributed to 25 publications, accounting for 16.4% of the total output, with \"Veterinary World\" leading at four publications. Among the authors, Bochnia M, Glatter M, Greef J, Grela E, Ilgaza A, Jogloy S, and Zeyner A were prominent, each contributing five articles. Chulalongkorn University in Thailand was the most prolific institution, contributing 16 studies. Thailand led in publication count with 44 articles and the most cited country was Turkey with 449 citations. Keyword analysis revealed \"Jerusalem artichoke,\" \"inulin,\" and \"<em>Helianthus tuberosus</em>\" as the most frequently occurring terms.</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis provides a comprehensive overview of the research landscape concerning the medicinal potential of <em>H. tuberosus</em>. The findings highlight key contributors, prevalent research themes, and collaborative networks, offering valuable insights for future research directions and potential therapeutic applications of this versatile plant.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102608"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends on the ketogenic diet–gut microbiota relationship: A bibliometric analysis","authors":"Emre Manisalı ,&nbsp;Kaan Zıkşahna ,&nbsp;Rumeysa Adıyıl ,&nbsp;Murat Ihlamur","doi":"10.1016/j.eujim.2026.102615","DOIUrl":"10.1016/j.eujim.2026.102615","url":null,"abstract":"<div><h3>Introduction</h3><div>The ketogenic diet (KD) has attracted increasing attention for its potential to modulate the gut microbiota; however, the rapidly expanding literature makes it difficult to identify dominant themes, leading contributors, and research gaps. This study aimed to map global research trends on the KD–gut microbiota relationship using bibliometric methods.</div></div><div><h3>Methods</h3><div>A bibliometric analysis was conducted using the Scopus database. Records published between January 1, 2009 and December 31, 2024 were included (search updated to January 1, 2025). Bibliometric indicators and performance analyses were computed, and keyword co-occurrence and international collaboration networks were visualized using VOSviewer.</div></div><div><h3>Results</h3><div>A total of 404 documents were identified. Publication output increased markedly after 2016 and peaked in 2024, indicating growing scientific interest. The most prolific authors and institutions contributed disproportionately to the field, and thematic mapping revealed five dominant clusters, including neurodegenerative diseases, metabolic regulation, and microbiota-related mechanisms. While the field is expanding, the distribution of document types suggests that conceptual and synthesis work remains prominent.</div></div><div><h3>Conclusion</h3><div>Research on the KD–gut microbiota relationship has grown substantially over the last decade, with clear thematic consolidation around metabolic and neurological outcomes. Future studies should prioritize mechanistic and longitudinal clinical designs and integrate multi-omics approaches to clarify causal pathways and support personalized dietary interventions.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102615"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a quantitative network pharmacology approach for TCM formulas: A case study of Ma Huang Tang","authors":"Hongsheng Liu ,&nbsp;Qi Yang ,&nbsp;Guiyuan Pang ,&nbsp;Meiyu Huang ,&nbsp;Lianxiang Lu ,&nbsp;Peiyuan Li ,&nbsp;Ben Chen ,&nbsp;Lini Huo","doi":"10.1016/j.eujim.2026.102611","DOIUrl":"10.1016/j.eujim.2026.102611","url":null,"abstract":"<div><h3>Introduction</h3><div>Network pharmacology is widely used to study the mechanisms of Traditional Chinese Medicine (TCM). However, existing methods do not account for the varying dosages of individual components in TCM formulas, which can affect result reliability. This study aimed to assess the impact of incorporating dosage information into network pharmacology for more accurate evaluation of TCM formulas.</div></div><div><h3>Methods</h3><div>A quantitative network pharmacology approach was developed by introducing the ‘Score of Quantitative Network Pharmacology’ (SQNP) as an evaluation index. Using Ma Huang Tang (MHT) as a case study, both qualitative and quantitative network pharmacology methods were applied to analyse key targets, Gene Ontology (GO) biological function enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The effects of dosage weighting were compared across both methods.</div></div><div><h3>Results</h3><div>The comparative analysis revealed that the quantitative method significantly improved the accuracy of identifying key targets. The top 10 targets were consistent in type but showed a significant change in ranking with the addition of dosage weighting. Biological function and pathway enrichment analysis also demonstrated higher reliability with the quantitative approach. The quantitative network pharmacology method provided a more comprehensive understanding of the therapeutic mechanisms of MHT.</div></div><div><h3>Conclusions</h3><div>Incorporating dosage information into network pharmacology using the SQNP method enhances the reliability of target identification and biological analysis for TCM formulas, offering a more accurate and scientifically robust evaluation for TCM research.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102611"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions for reducing pain and anxiety in women experiencing infertility undergoing hysterosalpingography: A systematic review without meta-analysis","authors":"Shu-Hsien Fang ,&nbsp;Ping-Shaou Yu ,&nbsp;Bih-O Lee ,&nbsp;Chien-Jen Chen","doi":"10.1016/j.eujim.2025.102609","DOIUrl":"10.1016/j.eujim.2025.102609","url":null,"abstract":"<div><h3>Introduction</h3><div>Hysterosalpingography (HSG) is a common diagnostic procedure for infertility but often causes pain and anxiety. Non-pharmacological interventions offer potential alternatives to pharmacological pain management.</div></div><div><h3>Methods</h3><div>A systematic review followed PRISMA 2020 guidelines where a search strategy was applied to extract articles from included databases: PubMed, CINAHL Plus with Full Text, Cochrane Library, EMBASE, DynaMed, Clinical Key, MEDLINE, and Airiti Library, published before December 2024. The Cochrane RoB (Risk of Bias) 2.0 tool was used to assess the risk of bias, and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) criteria were applied to evaluate study evidence.</div></div><div><h3>Results</h3><div>Eight randomized controlled trials (RCTs) met the inclusion criteria, covering educational counseling, virtual reality (VR), music therapy, mobile-assisted education (MAEC), and acupoint warming therapy. Educational counseling improved patient preparedness and reduced pain, technology-assisted interventions diverted attention, and acupoint warming therapy with music provided dual physiological and psychological benefits. It was also observed that anxiety was reduced in three related articles although study quality varied, with some limitations in blinding and sample size.</div></div><div><h3>Conclusion</h3><div>Non-pharmacological interventions reduced pain (low certainty) and anxiety (very low certainty) during hysterosalpingography. Concerns remain about the methodological quality, small sample sizes, heterogeneity in the interventions, and for anxiety outcomes, inconsistent effects. Further high-quality studies are needed to determine the optimal application, refine implementation, and support evidence-based application.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102609"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data mining in traditional Chinese medicine: a bibliometric analysis and literature review of research trends and clinical applications (2010–2025)","authors":"Wen-juan Song ,&nbsp;Xing Wang ,&nbsp;Xiao-gang Du","doi":"10.1016/j.eujim.2026.102612","DOIUrl":"10.1016/j.eujim.2026.102612","url":null,"abstract":"<div><h3>Introduction</h3><div>The application of data mining in Traditional Chinese Medicine (TCM) has gained considerable momentum in recent years. As bibliometric analysis can systematically quantify scientific outputs and identify research trends and knowledge gaps, we used this method to complement traditional literature reviews. This approach helps mitigate potential selection bias and provides a comprehensive perspective on the field's evolution. This study aims to characterize the research landscape of data mining in TCM by integrating bibliometric analysis with a literature review. We sought to identify technological trends, research hotspots, and clinical translation potential to guide future research.</div></div><div><h3>Methods</h3><div>We employed a combined approach of bibliometric analysis and literature review. We conducted a comprehensive literature search in the Web of Science Core Collection (WoSCC), including the Science Citation Index Expanded (SCIE) and Social Sciences Citation Index (SSCI) databases, covering publications from 2010 to 2025. Bibliometric analysis and visualization were performed using OriginPro2024, Bibliometrix(v5.0), VOSviewer(v1.6.20), and CiteSpace(v6.3.R1). To ensure comprehensive coverage, we also reviewed clinical and application studies from the China National Knowledge Infrastructure (CNKI) database, emphasizing TCM diagnosis, herb mining, and translational challenges.</div></div><div><h3>Results</h3><div>Among the 1501 publications analyzed, the field grew rapidly after 2020, with output peaking at 325 publications in 2024. China and the United States emerged as the leading contributing countries, with Beijing University of Chinese Medicine being among the top-performing institutions. Frequently used keywords included “machine learning,” “deep learning,” and “network pharmacology.” The research focus evolved through two distinct stages: correlation and application. However, clinical translation remains limited due to challenges such as data heterogeneity and difficulties in algorithm integration.</div></div><div><h3>Conclusion</h3><div>Bibliometric analysis and literature review together provide valuable evidence to guide the development of TCM data mining. Future studies should focus on developing algorithms capable of handling complex data, building standardized knowledge bases, and fostering international and cross-disciplinary collaboration to accelerate clinical translation.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102612"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147384808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-compassion and interoceptive awareness as mechanisms of change in yoga for emotional well-being: A secondary analysis of a randomized controlled trial","authors":"Camille L. Garnsey ,&nbsp;Katherine E. Gnall ,&nbsp;Joshua A. Wilt ,&nbsp;Crystal L. Park ,&nbsp;Sara Lazar","doi":"10.1016/j.eujim.2026.102619","DOIUrl":"10.1016/j.eujim.2026.102619","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Yoga practice is associated with improved emotional well-being (EWB), but little is known about the mechanisms of yoga that support EWB This post-hoc secondary analysis of a randomized controlled trial tested a) whether changes in self-compassion and interoceptive awareness were associated with changes in EWB (i.e., meaning in life, sense of inner peace, ability to pursue goals) over the course of a yoga intervention, and b) whether amount practiced relates to changes in proposed mechanisms and EWB outcomes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Eighty-four participants who self-identified as stressed were randomized to varying doses of a 12-week Kripalu-style yoga intervention. As part of the parent clinical trial, participants completed self-report surveys at baseline, mid-treatment, and post-treatment assessing self-compassion (Self-Compassion Scale, Short Form), elements of interoceptive awareness (The Multidimensional Assessment of Interoceptive Awareness) and domains of emotional well-being (peace, meaning, ability to pursue goals; Functional Assessment of Chronic Illness Therapy–Spiritual Well-being Scale; Brief Self Control Scale). Seventy-five participants from the parent study had data for at least one of the main study variables and were thus included in this secondary analysis. To examine whether changes in hypothesized mechanisms (self-compassion, interoceptive awareness) were associated with changes in EWB outcomes, standardized residuals reflecting relative change were obtained by regressing post-treatment scores on baseline scores for all variables. Then, partial correlations (controlling for gender, age and site) between the standardized residuals for changes in mechanisms and changes in EWB were examined. To examine a potential dose effect, partial correlations between average weekly practice and change in both mechanisms and three EWB outcomes were conducted, controlling for home-practice randomization group, gender, age, and study site.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Over the course of the intervention (T1 to T3), changes in self-compassion were associated with changes in both meaning and peace (&lt;em&gt;r&lt;/em&gt;s = 0.52, 0.54, respectively, &lt;em&gt;ps&lt;/em&gt; &lt; 0.001), but not with changes in ability to pursue goals (&lt;em&gt;r&lt;/em&gt; = 0.15, &lt;em&gt;p&lt;/em&gt; = .21). Over the course of the intervention (T1 to T3), changes in the interoceptive awareness subscale of trusting were associated with changes in peace (&lt;em&gt;r&lt;/em&gt; = 0.35, &lt;em&gt;p=&lt;/em&gt;.003) and changes in the attention regulation subscale were associated with changes in both meaning (&lt;em&gt;r&lt;/em&gt; = 0.37, &lt;em&gt;p&lt;/em&gt; = .001) and peace (&lt;em&gt;r&lt;/em&gt; = 0.34, &lt;em&gt;p&lt;/em&gt;=.003). Yoga dosage was associated with increases in self-compassion (&lt;em&gt;r&lt;/em&gt; = 0.34, &lt;em&gt;p&lt;/em&gt; = .04) only.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Findings provide promising preliminary evidence that yoga interventions and community classes may benefit from emphasizing self-compassion and body a","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102619"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of yoga on sleep quality, fatigue and physical activity levels in patients with multiple sclerosis: A randomized controlled trial","authors":"Dilara Özturk ,&nbsp;Gülcan Bahcecioglu Turan","doi":"10.1016/j.eujim.2025.102607","DOIUrl":"10.1016/j.eujim.2025.102607","url":null,"abstract":"<div><h3>Introduction</h3><div>Yoga may support symptom management in individuals with Multiple Sclerosis (MS) by improving sleep, reducing fatigue, and promoting physical activity. This study examined the effects of a six-week yoga program on sleep quality, fatigue, and physical activity levels in patients with MS.</div></div><div><h3>Methods</h3><div>This randomized controlled trial included 60 patients with MS (30 intervention, 30 control). The intervention group completed 12 yoga sessions over six weeks, while the control group received no intervention. Sleep quality, fatigue, and physical activity were assessed using the Pittsburgh sleep quality index (PSQI), Fatigue severity scale (FSS), and international physical activity questionnaire–short form (IPAQ-SF).</div></div><div><h3>Results</h3><div>Compared with the control group, the intervention group showed substantial improvements in sleep quality (mean difference −6.14, 95% CI −7.79 to −4.49). Fatigue severity was lower in the yoga group after the intervention (mean difference −1.48, 95% CI −2.44 to −0.52). Physical activity levels increased markedly in the intervention group (mean difference +1857.92 met-min/week, 95% CI 1355.7 to 2360.1). No adverse effects related to the yoga intervention were reported.</div></div><div><h3>Conclusion</h3><div>A six-week yoga program improved sleep quality, reduced fatigue, and significantly increased physical activity levels in individuals with MS. Yoga may be considered a beneficial complementary approach in the care and symptom management of patients with MS.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102607"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a core outcome set for traditional Chinese dietotherapy in type 2 diabetes","authors":"Qiuyun Xue ,&nbsp;Lixia Yuan ,&nbsp;Jieyi Zhou ,&nbsp;Wenxi Li ,&nbsp;Hui Wang ,&nbsp;Zijie Hong ,&nbsp;Xu Zhou","doi":"10.1016/j.eujim.2026.102618","DOIUrl":"10.1016/j.eujim.2026.102618","url":null,"abstract":"<div><h3>Introduction</h3><div>To develop a core outcome set (COS) for clinical research on traditional Chinese dietotherapy for type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>We conducted a systematic search of nine literature databases for randomized controlled trials (RCTs) on traditional Chinese dietotherapy or herbal medicine for T2D published between 2020 and 2022, from which outcomes and effect estimates were extracted. This was supplemented with semi-structured interviews with clinicians and patients/family members to form a candidate outcome pool. A Delphi expert survey was then employed to evaluate the importance of each outcome. Finally, a consensus meeting was held to establish the COS.</div></div><div><h3>Results</h3><div>The systematic literature review included 94 RCTs and 5 trial registration protocols, yielding 233 outcomes. Semi-structured interviews supplemented this with 8 additional outcomes. After cleaning, merging, and refining, 115 outcomes were excluded, resulting in a final candidate pool of 126 outcomes. These were categorized by functional attribute into a hierarchical framework comprising four primary domains: efficacy, safety, cost, and compliance. In the subsequent Delphi survey, the first round invited 40 experts, with 32 participating (response rate 80.0%); the expert authority coefficient was 0.732. Among 73 outcomes with importance scores below 85 or a coefficient of variation greater than 0.2, 72 were excluded by consensus meeting vote, one was retained, and 6 clinician-suggested outcomes were added, resulting in 60 outcomes proceeding to the second round. The second Delphi round invited 29 experts (response rate 90.6%), and the authority coefficient increased to 0.767. From 31 outcomes considered for exclusion in this round, 28 were ultimately excluded, and 3 were retained after the consensus meeting vote. The final consensus meeting established the Core Outcome Set for traditional Chinese dietotherapy in T2D (COS-TCD-T2D), which includes 32 outcomes categorized into four primary domains: efficacy (22 outcomes, further divided into 10 subdomains), safety (6 outcomes), cost (2 outcomes), and compliance (2 outcomes).</div></div><div><h3>Conclusion</h3><div>This study successfully developed the COS-TCD-T2D, which consists of 32 outcomes. It can serve as a standardized tool for outcome selection in clinical research on traditional Chinese dietotherapy and may also be applicable to other complementary treatments for T2D.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102618"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}