European Journal of Integrative Medicine最新文献

{"title":"Effect of different exercise modalities on health and quality of life in people with Parkinson’s disease: A systematic review and meta-analysis","authors":"Lihua Wang ,&nbsp;Qian Wang ,&nbsp;Mingze Sun ,&nbsp;Yan Zhang ,&nbsp;Xiao Qi","doi":"10.1016/j.eujim.2025.102541","DOIUrl":"10.1016/j.eujim.2025.102541","url":null,"abstract":"<div><h3>Introduction</h3><div>Parkinson's disease (PD) is a progressive neurodegenerative disorder, prevalent worldwide, with an unknown etiology and currently no specific treatment. Physical exercise-defined as “planned, structured, and repetitive physical activity aimed at improving or maintaining physical fitness”-has emerged as a non-pharmacological, holistic, and patient-centered intervention for the management of PD. This study aims to evaluate the impact of physical exercise on mental and physical health, and the quality of life in individuals with PD.</div></div><div><h3>Method</h3><div>A systematic search was conducted in PubMed, Web of Science (WoS), Embase, and the Cochrane Database for randomized controlled trials (RCTs) from their inception until December 2024. Key data extracted included publication details, sample demographic characteristics, the interventions used for both experimental and control groups, and outcome assessment characteristics at baseline and post-intervention. The Cochrane Risk of Bias tool was utilized to assess the risk of bias, and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework was applied to evaluate the certainty of the evidence.</div></div><div><h3>Result</h3><div>A total of 35 eligible articles (<em>n</em> = 1620) from 54 studies were included in our systematic review. The results demonstrated that physical exercise interventions had a significant effect on various outcomes, including global cognitive function (SMD 0.43, 95 % CI 0.01 to 0.85, <em>p</em> = 0.04), depression (SMD -0.54, 95 % CI -0.75 to -0.32, <em>p</em> &lt; 0.00001), anxiety (SMD -0.42, 95 % CI -0.69 to -0.15, <em>p</em> = 0.002), physical health (SMD -0.74, 95 % CI -1.01 to -0.48, <em>p</em> = 0.0002), balance (SMD 0.78, 95 % CI 0.36 to 1.19, <em>p</em> &lt; 0.00001), fatigue (SMD -0.65, 95 % CI -1.28 to - 0.01, <em>p</em> = 0.05), and quality of life (SMD -0.51, 95 % CI -0.80 to -0.22, <em>p</em> = 0.0005) in the experimental group (exercise training) compared to the control post-intervention. Most studies were assessed as having a low risk of bias, the quality of the included studies was generally high (median PEDro score = 7, range 5–10). Adverse events were reported in only 5 of 35 trials, with low incidence (3.1–16.1 %) and mild severity (e.g., musculoskeletal discomfort).</div></div><div><h3>Conclusion</h3><div>This review found moderate certainty evidence that physical exercise can improve depression, physical health, balance and quality of life, and low certainty evidence for improvements in cognitive function, anxiety and fatigue. Further research is indicated to provide clearer insights about the beneficial effects of exercise for PD.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102541"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pediatric Tui Na over three months on children’s growth: A systematic review and meta-analysis of randomized controlled trials","authors":"Huimin Su ,&nbsp;Hui Mao ,&nbsp;Yangyang Zhang ,&nbsp;Heng Yin ,&nbsp;Shenlin Chen ,&nbsp;Jiayi Hong ,&nbsp;Yuxuan Yang ,&nbsp;Yifei Song ,&nbsp;Shuxuan Chen ,&nbsp;Honghao Wang ,&nbsp;Landan Xu ,&nbsp;Hongjia Li ,&nbsp;Manci Zhou ,&nbsp;Xun Li","doi":"10.1016/j.eujim.2025.102548","DOIUrl":"10.1016/j.eujim.2025.102548","url":null,"abstract":"<div><h3>Introduction</h3><div>This review aims to evaluate the effectiveness and safety of pediatric Tui Na on children’s growth.</div></div><div><h3>Methods</h3><div>The protocol of this review was registered in INPLASY (10.37766/inplasy2024.2.0116). We searched seven databases and two ongoing trial registers up to June 8, 2024, for randomized controlled trials (RCTs) of pediatric Tui Na, to assess the impact of Tui Na lasting over 3 months on children’s growth. Risk of bias was assessed with the RoB1 tool. Results were presented and synthesized via RevMan 5.4.</div></div><div><h3>Results</h3><div>A total of 46 RCTs involving 11,284 children were included. We found that Tui Na increased height compared to routine health care alone (29 trials, mean 3.68 cm, 95 % CI (confidence interval) [2.92, 4.43], low-certainty evidence) and to touch (2 trials, mean 1.72 cm, 95 % CI [1.22, 2.22], low-certainty evidence). Adding Tui Na to touch resulted in a height increase of 1.99 cm (5 trials, mean 95 % CI [1.04, 2.95], low-certainty evidence). Subgroups of normal children (Tui Na for 3-4 months, 5-6 months, 12 months) and preterm children (Tui Na for 3-4 months, 12 months) both showed significant benefits. Tui Na was also beneficial for the growth of height, weight, head circumference, chest circumference, waist circumference and BMI, as well as parental satisfaction compared to routine health care. Compared to touch, Tui Na was beneficial for growth of height, weight and head circumference. Tui Na also showed additional benefits in growth of height, weight and head circumference added to touch. RevMan 5.4 was used for the meta-analyses and funnel plots.</div></div><div><h3>Conclusion</h3><div>This evaluation indicates that Tui Na over 3 months can promote children’s growth and appears to be safe, with high parental satisfaction. However, large-sample and high-quality RCTs and real-world observations with long-term follow-up are needed to confirm these findings.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102548"},"PeriodicalIF":1.7,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of Yiqi Jiedu decoction on diabetic peripheral neuropathy and related brain function changes: A randomized controlled trial protocol","authors":"Chaofan Sun ,&nbsp;Guoxing Ling ,&nbsp;Chunquan Sun ,&nbsp;Xingzhong Feng","doi":"10.1016/j.eujim.2025.102543","DOIUrl":"10.1016/j.eujim.2025.102543","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes, characterized by high disability and mortality rates. Pain, the primary symptom of DPN, leads to increased central nervous system responsiveness and decreased pain thresholds, resulting in conditions like hyperalgesia, anxiety, and depression—collectively referred to as \"central sensitization.\" Changes in brain structure and function are closely linked to this phenomenon but remain unclear. While functional magnetic resonance imaging (fMRI) technology can monitor brain function changes, there is limited research on the effects of interventions on these functions in patients with DPN. Yiqi Jiedu (YQJD) Decoction has been used in China to treat DPN for many years, with some studies indicating it may improve symptoms and quality of life, but there is a lack of high-quality clinical evidence, and its central mechanism of action remains unclear.</div></div><div><h3>Methods</h3><div>This ongoing randomized, double-blind, placebo-controlled trial aims to enroll about 88 patients aged 45–75 with DPN, diagnosed with qi deficiency and blood stasis syndrome. Participants will be randomly assigned in a 1:1 ratio to either receive YQJD Granules or the placebo, with follow-up assessments at weeks 4 and 8. The primary outcomes include the Toronto Clinical Scoring System (TCSS), Michigan Diabetic Neuropathy Score (MDNS), Traditional Chinese Medicine (TCM) syndrome score, nerve conduction velocity, and fMRI changes. Secondary outcomes will assess psychological characteristics in patients and changes in serum cytokines and glucose-lipid metabolism indicators.</div></div><div><h3>Discussion</h3><div>This study aims to evaluate the efficacy and safety of YQJD Decoction in the treatment of DPN using fMRI technology. It will analyze changes in brain regions before and after treatment, explore the cerebral effects of YQJD, and elucidate the relationship between central sensitization and brain effect patterns in the pathogenesis of DPN. The findings of this study will provide clinical evidence and mechanistic insights for the integration of TCM and Western medicine in the treatment of DPN. It is expected to reveal the central mechanisms involved in the intervention of neuropathic pain through Chinese herbal medicine.</div></div><div><h3>Trial registration</h3><div>Chinese clinical trial registry, ChiCTR2400084649. Registered on 22 May 2024, <span><span>https://www.chictr.org.cn/</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102543"},"PeriodicalIF":1.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of traditional Chinese exercises for sleep disturbances in older people: A systematic review and Bayesian network meta‐analysis","authors":"Zhengyang Mei ,&nbsp;Chenyi Cai ,&nbsp;Chifong Lam ,&nbsp;Tingfeng Wang ,&nbsp;Shi Luo","doi":"10.1016/j.eujim.2025.102540","DOIUrl":"10.1016/j.eujim.2025.102540","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep disturbances are increasingly prevalent, with older people particularly vulnerable due to age-related changes and the cumulative impact of psychosocial and health-related stressors. The objective of this systematic review and Bayesian network meta-analysis was to evaluate the comparative efficacy of traditional Chinese exercises (TCEs) for improving sleep disturbances in older people and to identify which intervention is the most effective.</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, EBSCOhost, Scopus, Web of Science, APA PsycINFO, the China National Knowledge Infrastructure (CNKI), Wanfang, the Chinese Scientific Journal Database (VIP), and Google Scholar for randomized controlled trials (RCTs) of TCEs in participants aged ≥60 years. We conducted pairwise and network meta-analyses using Stata version 18.0.</div></div><div><h3>Results</h3><div>The analysis included 17 RCTs involving a total of 1,730 participants. Pairwise meta-analyses indicated that TCEs effectively improved sleep disturbances in older people compared to the control groups (SMD = -0.48, 95 % CI [-0.69, -0.27], <em>p</em> &lt; 0.01). Network meta-analyses indicated that Qigong-Baduanjin exerted the strongest effect on older people’ sleep disturbances (SUCRA: 90.9 %), followed by Tai Chi (SUCRA: 71.8 %) and Qigong-Liuzijue (SUCRA: 46.1 %).</div></div><div><h3>Conclusions</h3><div>TCEs effectively improved sleep disturbances in older people, and Qigong-Baduanjin exerted the strongest effect, followed by Tai Chi and Qigong-Liuzijue. However, the findings of this review need to be interpreted and applied within specific clinical and patient contexts. When applying the results to clinical practice, careful consideration must be given to the specific circumstances and clinical needs of the patients.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102540"},"PeriodicalIF":1.7,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bailemian capsule for insomnia: a systematic review with meta-analysis","authors":"Yifan Yang ,&nbsp;Qinghao Cai ,&nbsp;Jiayu Huang ,&nbsp;Runru Mai ,&nbsp;Yuanyuan Hu ,&nbsp;Lijun Ouyang ,&nbsp;Zhimin Yang ,&nbsp;Biyun Xu","doi":"10.1016/j.eujim.2025.102537","DOIUrl":"10.1016/j.eujim.2025.102537","url":null,"abstract":"<div><h3>Introduction</h3><div><strong>:</strong> Bailemian capsule is a Chinese patent medicine widely used for insomnia. Recently, numerous new randomized controlled trials (RCTs) have been published. Our objective was to evaluate the efficacy and safety of Bailemian capsule.</div></div><div><h3>Methods</h3><div><strong>:</strong> Seven databases (EMBASE, PubMed, the Cochrane library, Web of Science, Chinese National Knowledge Infrastructure, Wanfang database and China Biomedical Literature database) were searched for RCTs of Bailemian capsule as of 24 February 2024. Primary outcomes were assessed with the Pittsburgh Sleep Quality Index (PSQI). The risk of bias was assessed by the Cochrane Collaboration's tool, and meta- analysis was performed using Review Manager 5.3. The review was registered in PROSPERO (CRD42024507706).</div></div><div><h3>Results</h3><div><strong>:</strong> A total of 15 RCTs involving 1547 participants were included. Compared with monotherapy, combining Bailemian capsules with sedating psychotropic drugs (MD = -3.74, 95 % CI [-4.99, -2.48], <em>Z</em> = 5.85, <em>P</em> &lt; 0.00001, I²= 87 %) or non-sedating psychotropic drugs (MD = -2.84, 95 % CI [-4.61, -1.08], <em>Z</em> = 3.16, <em>P</em> = 0.002, I²= 95 %) significantly reduced PSQI scores in patients with insomnia. The combination with non-sedating psychotropic drugs also significantly improved PSQI scores in patients with anxiety insomnia (MD = -1.28, 95 % CI [-1.85, -0.72], <em>Z</em> = 3.16, <em>P</em> &lt; 0.00001, I² = 0 %) and depressive/anxiety insomnia (MD = -4.34, 95 % CI [-4.91, -3.77], <em>Z</em> = 4.49, <em>P</em> &lt; 0.00001, I² = 0 %). Compared with sedating psychotropic drugs, the combination with Bailemian capsules led to greater reductions in PSQI scores in patients with insomnia disorder (MD = -3.55, 95 % CI: [-5.09, -2.00]; <em>Z</em> = 4.49, <em>P</em> = 0.0002, I2=92.9 %). Furthermore, the combination significantly reduced the incidence of adverse events compared with sedating (RR = 0.29, 95 % CI 0.17–0.50, <em>Z</em> = 4.47, <em>P</em> &lt; 0.00001, I² = 0 %) and non-sedating psychotropic drugs alone (RR = 0.42, 95 % CI 0.25–0.69, <em>Z</em> = 3.42, <em>P</em> = 0.0006, I² = 0 %).</div></div><div><h3>Conclusion</h3><div><strong>:</strong> This meta-analysis provides evidence for the efficacy and safety of Bailemian capsule in treating insomnia. However, with high heterogeneity and high risk of bias of the included studies, the recommendation of this conclusion remains cautious and requires further validation by high-quality clinical studies.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102537"},"PeriodicalIF":1.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional herbal medicine as an adjuvant therapy for preventing the recurrence of hepatocellular carcinoma after radical resection: Development and validation of a machine learning prediction model","authors":"Xinyu Yue ,&nbsp;Meihuan Fu ,&nbsp;Song Yu ,&nbsp;Huayue Shi ,&nbsp;Simo Cheng ,&nbsp;Xiaofeng Zhai","doi":"10.1016/j.eujim.2025.102535","DOIUrl":"10.1016/j.eujim.2025.102535","url":null,"abstract":"<div><h3>Introduction</h3><div>Hepatocellular carcinoma (HCC) is the most prevalent pathological subtype of primary liver cancer. Although numerous studies have proposed models to predict recurrence following radical resection of HCC, none have accounted for the potential impact of traditional Chinese medicine (TCM). This study aims to evaluate whether adjuvant therapy with traditional herbal medicine (THM) can extend recurrence-free survival (RFS) in patients with HCC and to develop clinical prognostic models to aid in assessing the risk of recurrence after hepatectomy.</div></div><div><h3>Methods</h3><div>Clinical data from 403 patients who underwent radical resection at Shanghai Changhai Hospital from 2002 to 2023 were collected. Patients were categorized into THM and non-THM groups on the basis of whether they received THM therapy in the early postoperative period following HCC resection, and survival analysis was conducted to assess the differences in RFS and overall survival (OS) between the two groups. To build the models, the data were split into training and testing sets. Twenty-one variables were selected using Lasso regression, and predictive models were subsequently constructed employing Cox proportional hazards regression and the random survival forest (RSF) method. A nomogram was then developed based on the Cox regression model. The models were validated and compared based on their discriminatory power, calibration performance, and clinical utility. A nomogram was then developed based on the Cox regression model.</div></div><div><h3>Results</h3><div>RFS was significantly better in the THM group than in the non-THM group (<em>p</em> &lt; 0.001), but there was no difference in OS between the two groups. The median RFS was 48.13 (95 % CI, 38.63, 57.64) months vs 18.07 months (95 % CI, 13.09, 23.04), and the 1-, 3-, and 5-year RFS rates in the THM and non-THM groups were 82.26 % vs 62.58 %, 62.10 % vs 35.55 % and 45.56 % vs 29.03 %, respectively. The variables identified through Lasso regression—including THM intervention, age, postoperative AFP levels, cirrhosis, tumor diameter, and gender—were incorporated into the development of both Cox and RSF models. Both models exhibited comparable performance with respect to discrimination, calibration, and clinical utility.</div></div><div><h3>Conclusion</h3><div>THM adjuvant therapy following HCC resection can effectively reduce the risk of early recurrence; however, it does not significantly extend overall survival. Cox regression and RSF prediction models were successfully established, and their combined application may aid clinicians in estimating individual recurrence risk and formulating personalized treatment strategies.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102535"},"PeriodicalIF":1.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary and alternative medicine use among patients with diabetes mellitus in Iran: A systematic review and meta-analysis","authors":"Seyede Maryam Najibi,&nbsp;Seyede Hamide Rajaie,&nbsp;Mohadeseh Ostovar,&nbsp;Mohammad Hashem Hashempur","doi":"10.1016/j.eujim.2025.102533","DOIUrl":"10.1016/j.eujim.2025.102533","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to systematically review the literature on the use of complementary and alternative medicine (CAM) among patients with diabetes in Iran.</div></div><div><h3>Methods</h3><div>Relevant studies were identified by searching international and Iranian databases up to August 2024. After study selection and data extraction, meta-analyses of proportions were performed using the DerSimonian and Laird random effects model. Subgroup analysis and sensitivity analysis were conducted to explore the sources of heterogeneity and evaluate the robustness of overall effects, respectively.</div></div><div><h3>Results</h3><div>The pooled prevalence of CAM use from nine studies was 62%. Heterogeneity was very high (I-squared (I²) = 99.03%) with a wide 95% prediction interval range of 14–95%. The most significant factor increasing the likelihood of CAM use was a positive attitude toward the safety of CAM. The most common sources of information on CAM were family and friends. Additionally, almost half of the participants disclosed the use of CAM to their healthcare provider.</div></div><div><h3>Conclusion</h3><div>The high prevalence of CAM use, alongside low rates of patient disclosure, underscores the critical importance of physician-patient communication. This reality makes it crucial for health professionals to engage in open discussions with patients about their CAM use, ensuring that such practices are safe and effective in conjunction with conventional diabetes management. Further research is recommended to explore the specific types of CAM utilized and their impacts on treatment success, and patient satisfaction.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102533"},"PeriodicalIF":1.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the development and validation of a patient centered assessment method questionnaire – patient version (PCAM-P) for use in chiropractic care generative","authors":"Cassie M. Argenbright ,&nbsp;Hayden J. Chighizola ,&nbsp;Kent J. Stuber ,&nbsp;Christopher A. Malaya","doi":"10.1016/j.eujim.2025.102530","DOIUrl":"10.1016/j.eujim.2025.102530","url":null,"abstract":"<div><h3>Introduction</h3><div>The biopsychosocial (BPS) model offers a holistic framework for patient care, yet its implementation in chiropractic settings remains limited. The Patient-Centered Assessment Method (PCAM) evaluates patient complexity within the BPS model but lacks a corresponding tool for direct patient self-report. This study aims to develop and validate a patient-facing version of the PCAM (PCAM-P) tailored specifically for chiropractic care, enabling comparison between patient and provider perspectives on BPS needs.</div></div><div><h3>Methods</h3><div>A multi-phase design will guide the development, refinement, and validation of the PCAM-P. Initial adaptation will involve expert review to ensure conceptual alignment with the original PCAM. Pilot testing and validation phases will assess face validity, construct validity, and reliability, including analyses of internal consistency and patient-provider congruency. Participants will include chiropractic patients presenting with pain and their providers, with data collected via secure, online platforms. Demographic and clinical information will be incorporated into all analyses. Primary outcomes will include the PCAM-P’s reliability and validity in assessing biopsychosocial complexity in chiropractic care. Secondary outcomes will evaluate the congruency of patient-provider assessments and the tool’s feasibility and utility in supporting BPS-informed communication and care delivery.</div></div><div><h3>Discussion</h3><div>This is the first study to develop and evaluate a mirrored BPS assessment tool specifically for chiropractic patients. The PCAM-P is designed to improve patient-provider communication, enhance care alignment, and support the integration of biopsychosocial principles into routine chiropractic practice.</div></div><div><h3>Conclusion</h3><div>The PCAM-P aims to provide a validated, patient-centered tool for biopsychosocial assessment in chiropractic care. Study findings aim to inform clinical practice guidelines and promote interdisciplinary applications of the BPS model, advancing holistic and collaborative care.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102530"},"PeriodicalIF":1.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ethnobotanical study of plants and traditional herbal therapies in the Kara-Koy Gorge, Kyrgyz Republic","authors":"Nurbek Aldayarov ,&nbsp;Askarbek Tulobaev ,&nbsp;Kadyrbai Chekirov ,&nbsp;Gulbubu Kurmanbekova ,&nbsp;Nazgul Imanberdieva ,&nbsp;Gulnara Sharshenalieva ,&nbsp;Nurjamal Omurzakova ,&nbsp;Bermet Kydyralieva","doi":"10.1016/j.eujim.2025.102529","DOIUrl":"10.1016/j.eujim.2025.102529","url":null,"abstract":"<div><h3>Introduction</h3><div>The Kara-Koy Gorge, located in the southern region of the Kyrgyz Republic, is home to a diverse array of plant species, many of which are known for their medicinal properties. Despite their historical use, the pharmacological properties of these plants remain largely unexplored. These species represent a potential source for the development of novel therapeutic agents. This study aimed to document traditional plant-based remedies, focusing on their preparation methods, therapeutic applications, and associated ailments, as reported by local custodians of traditional wisdom.</div></div><div><h3>Methods</h3><div>Ethnomedicinal data were collected between March 2021 and October 2022 through semi-structured interviews with local informants. Two ethnobotanical indices were applied to analyze the data. Plant specimens were collected, taxonomically identified, and preserved as voucher specimens.</div></div><div><h3>Results</h3><div>A total of 160 plant species, representing 123 genera and 47 botanical families were cited in homemade single-species herbal remedies. These remedies were employed for the treatment of 117 ailments, grouped into 14 therapeutic categories. The highest informant consensus factor values were recorded for digestive (0.86) and integumentary (0.84) disorders. <em>Dracocephalum imberbe</em> Bunge, <em>D. ferganicum</em> Lazkov, <em>Plantago major</em> L., and <em>Rosa canina</em> L. exhibited the highest use values of 0.98. Aerial parts were the most frequently used plant parts (37 %), and decoction was the predominant method of preparation (40 %).</div></div><div><h3>Conclusion</h3><div>The findings highlight the presence of underexplored plant species with significant ethnomedicinal potential. Future research should prioritize phytochemical profiling and pharmacological validation to substantiate and preserve this traditional local knowledge.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102529"},"PeriodicalIF":1.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety investigation of LIMAN technology based curcumin formulation on knee osteoarthritis: a randomized double-blind placebo-controlled trial","authors":"Girish HR ,&nbsp;Harshith N ,&nbsp;Nehru Sai Suresh Chalichem ,&nbsp;Abhijith Phanindra ,&nbsp;Mohammed S. Khan ,&nbsp;Jayant Deshpande","doi":"10.1016/j.eujim.2025.102531","DOIUrl":"10.1016/j.eujim.2025.102531","url":null,"abstract":"<div><h3>Introduction</h3><div>Knee osteoarthritis is the most common and extensively studied form of osteoarthritis, with varying prevalence reported across studies. Although the presentation of knee osteoarthritis can differ among individuals, it typically manifests as joint pain, stiffness, and restricted mobility, often accompanied by muscle weakness and balance issues. The present clinical study aimed to evaluate the safety and efficacy of Maxicuma®, a highly bioavailable form of curcumin, made from ethanolic extract of turmeric, at two different doses in reducing the symptoms and improving the functional status in individuals with knee osteoarthritis.</div></div><div><h3>Methods</h3><div>A total of 180 subjects with knee osteoarthritis as per NICE criteria were recruited into the study and severity of either Grade II or Grade III was assessed by radiographic analysis as per Kellgren-Lawrence (KL) scale. Participants received a daily single dose of either placebo, Maxicuma 100 or Maxicuam 250 per day for 90 days. Efficacy was assessed using WOMAC (Western Ontario and McMaster Universities Arthritis Index), VAS (Visual analog scale) and treadmill walk test to understand severity, intensity of pain and physical performance respectively, at day 30, day 45, day 60 and day 90.</div></div><div><h3>Results</h3><div>The test item was well tolerated with no major adverse events reported. A total of 180 and 174 subjects were considered for intention-to-treat and per-protocol analysis, respectively. Both doses of Maxicuma® demonstrated statistical significance (<em>p</em> &lt; 0.05) compared to placebo starting from day 30 across all efficacy measures.</div></div><div><h3>Conclusion</h3><div>Findings from this clinical study indicate that Maxicuma® 100 mg and 250 mg are effective and well-tolerated supplement options for managing knee osteoarthritis. Both dosages showed potential in improving clinical symptoms and enhancing functional outcomes.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102531"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}