European Journal of Integrative Medicine最新文献

{"title":"Evolving research methodologies are shaping the future of integrative medicine","authors":"Jennifer Hunter , Guo-Yan Yang , Nicola Robinson","doi":"10.1016/j.eujim.2024.102420","DOIUrl":"10.1016/j.eujim.2024.102420","url":null,"abstract":"","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102420"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hotspots and trends in global antiviral herbal basic research: A visualization analysis","authors":"Liangyu Hu,&nbsp;Chunying Wang,&nbsp;Yang Zhang","doi":"10.1016/j.eujim.2024.102419","DOIUrl":"10.1016/j.eujim.2024.102419","url":null,"abstract":"<div><div>Introduction: Viral infections can become public health emergencies due to the possibility of the wide transmission of their associated pathogens and their rapid variation. Moreover, most viruses lack effective therapeutic drugs and vaccines. Herbal medicines have been clinically validated for their broad-spectrum antiviral properties and their ability to leverage their complex compositions to target multiple levels, pathways, and channels. In this study, we seek to assess the current global research landscape and identify current and future directions for research on antiviral herbal medicines to guide future pharmacological developments. Methods: Bibliometric and visualization methods were used to analyze 2134 Chinese-language and 4600 English-language journal articles published between 2017 and 2022 from both Chinese and international databases, and the theme words and foci of highly cited papers were analyzed. Results: It was found that coronaviruses (especially severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), the influenza virus, the hepatitis B virus, and the human immunodeficiency virus were the primary targets for antiviral herbal medicines. Key herbs included <em>Glycyrrhiza glabra, Lonicera japonica, Scutellaria baicalensis, Ephedra sinica, Forsythia suspensa, Agastache rugosa, Astragalus membranaceus</em>, and <em>Poria cocos</em>. The primary active compounds known to be responsible for these antiviral effects are alkaloids, bioflavonoids, flavonoids, sterols, and polyphenols, including curcumin, quercetin, kaempferol, wogonin, stigmasterol, β-glutosterol, luteolin, coumarins, naringenin, gallic acid, berberine, and andrographolide. These compounds work through mechanisms such as inhibiting viral replication, blocking virus–receptor interactions, destroying viruses, regulating the immune response, oxidative stress induction, and cytokine response suppression. Conclusions: The research foci included the pharmacodynamic foundations, molecular dynamics simulation, and virtual screening of active components in herbs use for the treatment of viral diseases such as SARS-CoV-2 using bioinformatics, macromolecular docking, and network pharmacology. Significant gaps remain in interdisciplinary collaboration, especially regarding herb cultivation, processing, sustainable harvesting, and potential drug interactions.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102419"},"PeriodicalIF":1.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of Qianjinweijing decoction in the treatment of bronchiectasis: A systematic review and meta-analysis","authors":"Limin Zhang,&nbsp;Jin Su,&nbsp;Xiaozheng Wu,&nbsp;Wen Li,&nbsp;Yunzhi Chen","doi":"10.1016/j.eujim.2024.102418","DOIUrl":"10.1016/j.eujim.2024.102418","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Bronchiectasis is a chronic inflammatory airway disease marked by permanent dilation of the bronchi, recurrent infections, and associated complications. The traditional Chinese medicine Qianjinweijing Decoction (QJWJ) has shown promising results in bronchiectasis treatment with few side effects. However, there is a lack of recent comprehensive research evaluating its effectiveness. This review aims to examine the effectiveness and safety of QJWJ in treating bronchiectasis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We searched 7 databases including China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Chinese Science Database, China Biology Medicine Disc (Sinomed), PubMed, Embase, and Cochrane Library, for relevant randomized controlled trials (RCTs) until May 2023, in both Chinese and English. Two researchers conducted a comprehensive review of literature, extracting data based on predefined criteria. The risk of bias was assessed using the Cochrane Collaboration tool, and meta-analysis was performed using RevMan 5.4.1 and RStudio software. Quality of evidence was evaluated using GRADEpro (V3.6.) software.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;This review analysed 35 studies with 2609 patients. The QJWJ group consisted of 1318 patients, while the routine pharmacotherapy (RP) group had 1291 patients. Combining QJWJ and RP in bronchiectasis treatment showed better with clinical effectiveness [risk ratio (RR)=1.17, 95 % confidence interval (CI) (1.13, 1.21), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], the percentage of forced expiratory volume in the first second to the predicted value (FEV&lt;sub&gt;1&lt;/sub&gt; %) [mean difference (MD)=3.52, 95 % CI (1.48, 5.55), &lt;em&gt;P&lt;/em&gt; = 0.0007], the ratio of forced expiratory volume to forced vital capacity in the first second (FEV&lt;sub&gt;1&lt;/sub&gt;/FVC) [MD=6.62, 95 % CI (1.52, 11.72), &lt;em&gt;P&lt;/em&gt; = 0.01], peak expiratory flow rate (PEFR) [MD=7.14, 95 % CI (5.15, 9.12), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], white blood cell count (WBC) [MD=-1.42, 95 % CI (-2.53, -0.31), &lt;em&gt;P&lt;/em&gt; = 0.01], c-reactive protein (CRP) [MD=-7.2, 95 % CI (-9.3, -5.1), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], and the procalcitonin (PCT) [standardized mean difference (SMD)=-1.39, 95 % CI (-2.02, -0.76), &lt;em&gt;P&lt;/em&gt; &lt; 0.0001], without increasing the incidence of adverse reactions [RR=0.79, 95 % CI (0.44, 1.42), &lt;em&gt;P&lt;/em&gt; = 0.43]. QJWJ alone also significantly improved bronchiectasis treatment, enhanced clinical effectiveness [RR=1.19, 95 % CI (1.04, 1.36), &lt;em&gt;P&lt;/em&gt; = 0.010], FEV&lt;sub&gt;1&lt;/sub&gt; % [MD=7.09, 95 % CI (4.5, 9.68), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], and reduced WBC [MD=-2.7, 95 % CI (-3.7, -1.7), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], CRP [MD=-4.22, 95 % CI (-55.32, -3.12), &lt;em&gt;P&lt;/em&gt; &lt; 0.00001], without increasing the incidence of adverse reactions [RR=0.20, 95 % CI (0.01, 4.06), &lt;em&gt;P&lt;/em&gt; = 0.29].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Evidence suggested that QJWJ, used alone or with RP, notably improved bronchiectasis treatment outcomes, enhanced lung fun","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102418"},"PeriodicalIF":1.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflexology specific guidance for using the template for the intervention description and replication (TIDieR): A delphi study","authors":"Jacqueline James ,&nbsp;Joseph T. Costello ,&nbsp;Sally Edwards-Price ,&nbsp;Tracey Smith ,&nbsp;Amanda McAuley ,&nbsp;Barbara E. Scott ,&nbsp;Spyridon Dimitrakoulas ,&nbsp;Marcia Edwards ,&nbsp;Dorothy Kelly ,&nbsp;David L. Wayte ,&nbsp;Andrea F. Porritt ,&nbsp;Amy K. Drahota","doi":"10.1016/j.eujim.2024.102416","DOIUrl":"10.1016/j.eujim.2024.102416","url":null,"abstract":"<div><h3>Introduction</h3><div>Reflexology is a holistic, complementary therapy, carried out on the feet, hands, ears, or face. There is no single accepted definition of reflexology, as it encompasses various practices, making it important that research studies articulate exactly what the reflexology intervention entailed.</div><div>This study sought to produce reflexology-specific guidance for researchers and practitioners, for use with the Template for the Intervention Description and Replication (TIDieR) checklist, to improve the quality of the documentation of reflexology interventions within the research literature.</div></div><div><h3>Method</h3><div>This study used the TIDieR checklist as a framework for a three-round Delphi process to gain agreement on what information authors should consider including in their study report to support replication of their intervention. Following the Delphi process two online consolidation meetings were held to agree the wording and examples for the guidance document.</div></div><div><h3>Results</h3><div>Guidance based on the unique considerations of reflexology interventions was developed for use with the TIDieR checklist.</div><div>A diverse group of 43 experts from Europe, North America, Asia, and Australasia, including 40 reflexologists, 9 of whom were also study authors, and 2 methodological specialists contributed to the guidance.</div><div>Each Delphi round was completed by 39 to 42 (91 % to 98 %) of the 43 panel members, and 16 (37 %) participated in the consolidation meetings. Consensus was reached on 46 items via the Delphi rounds (36 to be included in the guidance and 10 to be excluded); 38 items failed to reach consensus. The consolidation meetings informed the final wording of the guidance document, covering all the 12 TIDieR domains.</div></div><div><h3>Conclusion</h3><div>The reflexology-specific guidance strongly advocates for the utilisation of the TIDieR checklist, with elaboration tailored for reflexology as used in various contexts internationally. By serving as a reporting guide for reflexology intervention studies, this tool has the capacity to improve the reporting of reflexology intervention studies, thereby facilitating replicability and promoting greater transparency within the field of reflexology.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102416"},"PeriodicalIF":1.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurveda interventions for non-specific chronic low back pain— protocol for a systematic review and network meta-analysis","authors":"Ritu Kumari,&nbsp;Mandip Goyal,&nbsp;Kalpesh Panara","doi":"10.1016/j.eujim.2024.102413","DOIUrl":"10.1016/j.eujim.2024.102413","url":null,"abstract":"<div><h3>Introduction</h3><div>Low back pain (570 million prevalent cases worldwide) is the main contributor to the overall burden of musculoskeletal conditions. The most common form of low back pain is non-specific low back pain (NSCLBP) (almost 90 %). There are no treatments that completely cure chronic low back pain. Ayurveda is one of the traditional systems of Indian medicine commonly practiced in Southeast Asian countries. Even though Ayurveda interventions (oral medication or procedure-based treatment or combined therapy) are practiced widely for this condition, there is ambiguity about the hierarchy of treatment. The present review has been planned to compare all the available Ayurveda treatment modalities for NSCLBP in terms of efficacy, and safety, in all the age groups of patients.</div></div><div><h3>Methods</h3><div>This review will be written in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the PRISMA extension for network meta-analyses. Electronic searches will be carried out in PubMed, Scopus, TRIP, Website of Indexing of Indian Medical Journals, the Cochrane Register for Controlled Trials, The Clinical Trials Registry- India, AYUSH research portal, and Digital Helpline for Ayurveda Research Articles, and other pre-print repositories since its inception till 31st March 2024. Randomized controlled trials, randomized cross-over studies, cluster-randomized studies, and nonrandomized studies of interventions (prospective cohort studies, non-randomized clinical trials) will be included. The risk of bias will be assessed with ROB-2, ROBINS-I, and other revised risk of bias tools for cross-over studies and cluster randomised studies recommended by the Cochrane collaboration. To evaluate the credibility of the findings, the Grading of Recommendations Assessment, Development, and Evaluation method for network meta-analysis will be implemented. A narrative approach to synthesize and report qualitative and quantitative data will be used, and where feasible, we will conduct network meta-analyses using STATA software.</div></div><div><h3>Conclusions</h3><div>This protocol defines a plan of the study that would facilitate the process of recommending treatment for NSCLBP, by providing a treatment hierarchy of Ayurvedic treatment to the policymakers and stakeholders.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102413"},"PeriodicalIF":1.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic signature in ocular dosing: Exploring the metabolic impacts of sublethal high-dose naringenin on ARPE-19 cells","authors":"Ozan Kaplan ,&nbsp;Emine Koç ,&nbsp;Seyhan Türk ,&nbsp;Tuba Tüylü Küçükkılınç ,&nbsp;Zeynep Göktaş ,&nbsp;Mustafa Çelebier","doi":"10.1016/j.eujim.2024.102414","DOIUrl":"10.1016/j.eujim.2024.102414","url":null,"abstract":"<div><h3>Introduction</h3><div>Naringenin (NRG), a flavanone polyphenol found in citrus fruits, has been increasingly recognized for its potential therapeutic effects in ocular disorders. This study aimed to assess the impact of high-dose NRG on human retinal pigment epithelial cells (ARPE-19) cells through metabolomic analysis.</div></div><div><h3>Methods</h3><div>Cell viability was evaluated using the thiazolyl blue tetrazolium bromide (MTT) assay, demonstrating non-cytotoxicity at concentrations ranging from 3 to 100 μM within a 24-h exposure period. High-dose (100 μM) NRG was selected for further investigation based on its non-cytotoxic nature. Chromatographic analyses were performed using Liquid Chromatography Quadropole Time-of-Flight Mass Spectrometry (LC-Q-ToF-MS).</div></div><div><h3>Results</h3><div>Metabolomic analysis revealed subtle metabolic changes, with similar profiles between control and test groups, emphasizing the nuanced effects of NRG. Multivariate analysis, including Principal Component Analysis (PCA), illustrated distinct clustering of control and test groups, indicating consistent metabolic adjustments within each group. Despite maintaining cell viability, stress responses were identified in ARPE-19 cells, as evidenced by reduced glucose-6-phosphate levels and alterations in pyrimidine/purine pathways. This highlights the importance of exploring cellular responses using metabolomics beyond traditional viability metrics.</div></div><div><h3>Conclusion</h3><div>In the broader context, this study contributes data on the interplay between NRG and retinal pigmented epithelial. As NRG is utilized in routine ocular applications, particularly as an eye drop, our findings suggest careful dosage selection, considering both non-irritability and subtle metabolic changes. Further research is needed to refine dosage strategies and comprehensively assess the safety profile of NRG in ocular applications.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102414"},"PeriodicalIF":1.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of neuromodulatory effects of Origanum punonense danin essential oil on AMPA receptor function using whole-cell patch-clamp technique","authors":"Mohammad Qneibi ,&nbsp;Kamal Issa ,&nbsp;Amjad Bakhatan ,&nbsp;Majde Abu Khaled ,&nbsp;Sosana Bdir ,&nbsp;Mohammad Bdair ,&nbsp;Dana Sandouka ,&nbsp;Nidal Jaradat","doi":"10.1016/j.eujim.2024.102411","DOIUrl":"10.1016/j.eujim.2024.102411","url":null,"abstract":"<div><h3>Introduction</h3><div>: The quest for natural compounds with neuromodulatory properties has gained significant momentum in neuropharmacology. Among these, <em>Origanum punonense (O. punonense)</em> essential oil (EO) stands out due to its rich bioactive profile, particularly characterized by carvacrol. This study aimed to elucidate the effects of <em>O. punonense</em> EO on α-amino-3‑hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), crucial synaptic plasticity, and cognitive function mediators.</div></div><div><h3>Methods</h3><div>: Leaves of <em>O. punonense</em> were collected along the Dead Sea coast in Jericho. After washing, it was dried in the shade for 15 days and ground. Essential oil was extracted using a microwave-ultrasonic method, with ultrasonic waves to enhance extraction. Using whole-cell patch-clamp techniques, we studied the effects of <em>O. punonense EO</em> on AMPAR kinetics in HEK293t cells transfected with homomeric and heteromeric subunits.</div></div><div><h3>Results</h3><div>: <em>O. punonense</em> EO significantly reduced AMPAR's whole-cell currents, indicating a targeted modulation of synaptic responses. Oil administration inhibited the currents for glutamate receptor subunits GluA1 (reduced from 885±58 pA to 342±20 pA), GluA1/2 (from 627±77 pA to 209±36 pA), GluA2 (from 1125±112 pA to 256±37 pA), and GluA2/3 (from 474±79 pA to 125±31 pA). The EO decreased the desensitization rate significantly for GluA2 and GluA2/3 (<em>p</em> &lt; 0.01) and for GluA1/2 (<em>p</em> &lt; 0.05), except for GluA1. In addition, the EO increased the deactivation rate significantly for GluA2 and GluA2/3 (<em>p</em> &lt; 0.01) and for GluA1/2 (<em>p</em> &lt; 0.05), with no effect observed on GluA1.</div></div><div><h3>Conclusions</h3><div>: This study highlights the possible properties of <em>O. punonense</em> EO and suggests future research to understand its medicinal benefits in neurodegenerative diseases.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"72 ","pages":"Article 102411"},"PeriodicalIF":1.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dose-effect relationship of acupuncture in the treatment of functional gastrointestinal disorders: A meta-regression of randomized controlled trials","authors":"Siyao Gong,&nbsp;Xin Yu,&nbsp;Jiao Yang,&nbsp;Dan Huang,&nbsp;Shuguang Yu,&nbsp;Sha Yang","doi":"10.1016/j.eujim.2024.102406","DOIUrl":"10.1016/j.eujim.2024.102406","url":null,"abstract":"<div><h3>Introduction</h3><div>The efficacy of acupuncture in treating functional gastrointestinal disorders (FGIDs) has been widely acknowledged. However, the dose-response relationship between acupuncture frequency and FGIDs remains uncertain. This review aimed to explore the relationship between the number of acupuncture sessions and the efficacy of acupuncture for FGIDs.</div></div><div><h3>Methods</h3><div>Seven major databases were searched from their inception to April 25, 2023. Literature screening, risk of bias assessment, and data extraction were performed by two reviewers independently. The quality of included randomized controlled trials (RCTs) was assessed using the Cochrane bias risk tool and Jadad score. The dose-effect relationship between acupuncture sessions and the clinical response rate in patients with FGIDs was investigated by using the cubic spline limited nonlinear meta-regression method in statal5.1. Before the review, we conducted the PROSPERO registration (CRD42022344699).</div></div><div><h3>Results</h3><div>Our analysis included 100 studies on acupuncture treatment of FGIDs, encompassing 8,589 participants. The meta-analysis of the dose-response relationship indicated that acupuncture could improve clinical symptoms and clinical response in patients with FGIDs to some extent. The clinical response rate increased with the number of acupuncture sessions in the range of ten to twenty sessions, with the odds ratio (OR) value rising from 1.05 (95 % CI: 0.89, 1.21) to 1.38 (95 % CI: 1.22,1.53). The peak of clinical response rate was observed at 24 acupuncture sessions (OR = 1.40; 95 % CI: 1.25, 1.55), representing a 40 % increase in OR. Compared with 24 sessions, the clinical response rate decreased after 56 sessions (OR = 1.22; 95 % CI: 0.64, 1.81).</div></div><div><h3>Conclusion</h3><div>There is a dose-response relationship between the number of acupuncture sessions and the clinical response in individuals with FGIDs. Twenty-four acupuncture treatments correlate with the optimal clinical response.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"71 ","pages":"Article 102406"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and anti-urease activities of Cardamine bulbifera: Insights from molecular docking and density functional theory studies","authors":"Emine İncilay Torunoğlu ,&nbsp;Erdi Can Aytar ,&nbsp;Betül Aydın ,&nbsp;Alper Durmaz","doi":"10.1016/j.eujim.2024.102410","DOIUrl":"10.1016/j.eujim.2024.102410","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Cardamine bulbifera</em> (L.) Crantz, commonly known as “Asian bittercress”, is a plant species widely distributed across Asia. It belongs to the Brassicaceae and has been traditionally used in medicinal applications. This study investigates the phytochemical composition, phenolic content, antioxidant properties, and anti-urease activity of <em>C. bulbifera.</em></div></div><div><h3>Methods</h3><div>In this study, the aerial parts of the <em>C. bulbifera</em> were collected. The total polyphenol content of the extracts was determined using spectrophotometric methods, and its antioxidant and anti-urease activities were assessed. The chemical composition was characterised using gas chromatography-mass spectroscopic (GC-MS) analysis. Additionally, molecular docking studies explored potential interactions between the identified compounds and <em>Helicobacter pylori</em> CagA oncoprotein. Furthermore, Density Functional Theory (DFT) analysis provided valuable insights into the electronic properties of the main compounds.</div></div><div><h3>Result</h3><div>The total phenolic content of <em>C. bulbifera</em> extract was 225 ± 0.02 mg GAE/g extract DW, and the total flavonoid content was 62.64 ± 3.27 mg QE/g extract DW. The 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay revealed an IC₅₀ value of 1.01 ± 0.04 mg/mL, indicating significant antioxidant activity. The IC₅₀ value for anti-urease activity was determined to be 2.74 ± 0.03 µg/mL, suggesting potent inhibition of urease enzyme activity. GC-MS analysis identified 15 bioactive compounds in the extract. Molecular docking studies highlighted Phenol, 3,5-bis(1,1-dimethylethyl) and 1-dodecanol as compounds with the highest binding affinity for the <em>H. pylori</em> CagA oncoprotein, suggesting potential therapeutic implications against <em>H. pylori</em>-related cancers. Additionally, DFT analysis emphasised these compounds' electronic properties and chemical reactivities, indicating their potential role in future pharmaceutical developments.</div></div><div><h3>Conclusion</h3><div><em>C. bulbifera</em> exhibits rich phenolic and flavonoid content and significant antioxidant and intense urease inhibition activities. These findings suggest that <em>C. bulbifera</em> may offer potential therapeutic options for conditions related to <em>H. pylori</em> infections, including cancer. Further research is needed to explore its mechanisms of action and clinical applications in more detail.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"71 ","pages":"Article 102410"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should eighteen incompatibilities be used? A systematic review and meta-analysis of the analgesic effect of pinellia and aconitum used externally for cancer pain","authors":"Can Cao ,&nbsp;Xiaoqing Liu ,&nbsp;Meijing Wu ,&nbsp;Xiangnan Xu ,&nbsp;Wenyong Liao ,&nbsp;Xiao Dong ,&nbsp;Yi Tian ,&nbsp;Ying Zhang ,&nbsp;Gansheng Zhong","doi":"10.1016/j.eujim.2024.102407","DOIUrl":"10.1016/j.eujim.2024.102407","url":null,"abstract":"<div><h3>Introduction</h3><div>Many clinical formulas containing the couplet Chinese medicines pinellia and aconitum (CMPA) have been recognized and demonstrated analgesic efficacy. However, CMPA belongs to the \"eighteen incompatibilities\" of traditional Chinese medicine theory, which is considered prohibited and dangerous by some medical practitioners. Whether CMPA can truly be used safely and without concern in the clinic urgently requires a more cohesive evaluation of the evidence. This review aims to evaluate the effectiveness and safety of CMPA for external use in the treatment of cancer pain.</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, and Sinomed databases to collect randomized controlled trials (RCTs) comparing CMPA with conventional medicines for the treatment of cancer pain from their inception to December 31, 2023. Meta-analysis was conducted using RevMan 5.4 software. The modified Cochrane risk of bias tool was used to assess the quality of the included studies, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) evidence profile was constructed to illustrate the certainty of evidence.</div></div><div><h3>Results</h3><div>A total of 1083 patients were enrolled in 14 RCTs. The results of the meta-analysis showed that the numerical rating scale (NRS) pain score [MD=-0.84, 95 % CI (-1.21, -0.47), <em>P</em> &lt; 0.00001, moderate certainty], duration of continuous analgesia [MD=1.45 h, 95 % CI (1.13, 1.77), <em>P</em> &lt; 0.00001, low certainty], and Karnofsky performance status (KPS) quality of life score [MD=7.25, 95 % CI (5.01, 9.48), <em>P</em> &lt; 0.00001, low certainty] of patients after external administration of CMPA-containing prescriptions in combination with conventional medicine therapy were better than those with the conventional medicine therapy. The incidence of total adverse reactions [RR=0.69, 95 % CI (0.58, 0.83), <em>P</em> &lt; 0.0001, moderate certainty] and constipation [RR=0.43, 95 % CI (0.19, 0.97), <em>P</em> = 0.04, moderate certainty] of patients after external administration of CMPA-containing prescriptions in combination with conventional medicine therapy were lower than those with the conventional medicine therapy. No statistically significant differences were found regarding the effectiveness or safety of CMPA-containing prescriptions compared to conventional medicine therapy (low or very low certainty evidence).</div></div><div><h3>Conclusion</h3><div>The external use of CMPA-containing prescriptions, when combined with conventional medicine therapy, is safer and more effective for cancer pain than conventional medicine therapy. However, higher-level evidence is still warranted.</div></div><div><h3>Review registration</h3><div>PROSPERO registration number: CRD42023400792.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"71 ","pages":"Article 102407"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}