European Journal of Integrative Medicine最新文献

{"title":"Complementary and integrative health approaches used for pain management by U.S. adults with chronic fatigue syndrome/myalgic encephalomyelitis: Findings from the 2022 National Health Interview Survey","authors":"Jenna L. Adamowicz ,&nbsp;Zoe Sirotiak ,&nbsp;Emily B.K. Thomas ,&nbsp;Brian C. Lund ,&nbsp;Katherine Hadlandsmyth ,&nbsp;Mary A. Driscoll","doi":"10.1016/j.eujim.2025.102443","DOIUrl":"10.1016/j.eujim.2025.102443","url":null,"abstract":"<div><h3>Introduction</h3><div>While most persons with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) experience pain, traditional pain treatments may be harmful or unfavorable to this population. Complementary and integrative health approaches for pain management offer a potentially important alternative. However, there is a paucity of research regarding which pain treatments patients with CFS/ME use. This study examined the prevalence of pain-related complementary and integrative health usage in CFS/ME adults and the factors that may be associated with usage, such as sex and anxious and depressive symptoms.</div></div><div><h3>Methods</h3><div>Using 2022 U.S. National Health Interview Survey data, seven different complementary and integrative health approaches were examined. Survey weights and variance estimation variables were utilized, and Rao-Scott chi-square test examined group-based differences.</div></div><div><h3>Results</h3><div>A total of 453 individuals (1.6 %) reported currently having CFS/ME. About one third (32.3 %) of the CFS/ME sample reported using complementary and integrative health approaches for pain management. The most commonly reported treatments were meditation (15.1 %), chiropractic care (14.5 %), and massage (10.7 %). Females with CFS/ME were significantly more likely to use pain-related complementary and integrative health approaches relative to their male counterparts (39.1 % vs. 24.3 %, respectively; χ² (1) = 5.90, <em>p</em> = 0.015). Usage of pain-related complementary and integrative health approaches did not differ significantly among those with or without clinically elevated anxious or depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Overall, persons with CFS/ME appear to use pain-related complementary and integrative health modalities at a lower rate relative to the general population. Although complementary and integrative health use was common, over half of the sample were not using these modalities, highlighting an opportunity for broader dissemination for pain management purposes.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102443"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into add-on effectiveness of Chinese herbal formulae in COVID-19: An overview of systematic reviews","authors":"Bo Li ,&nbsp;Yi-Ying Wang ,&nbsp;Le-yan Hu ,&nbsp;Jie Lian ,&nbsp;Shuai Dong ,&nbsp;Guo-dong Li ,&nbsp;Jia-xin Wang ,&nbsp;Zheng Li ,&nbsp;Hui-juan Cao","doi":"10.1016/j.eujim.2025.102440","DOIUrl":"10.1016/j.eujim.2025.102440","url":null,"abstract":"<div><h3>Introduction</h3><div>Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, overwhelming healthcare systems. Numerous clinical trials have explored the efficacy of Chinese herbal formulae (CHFs) in treating COVID-19, resulting in a surge of systematic reviews (SRs). This review critically evaluates the additive effectiveness of CHFs for COVID-19, aiming to provide a robust foundation for high-quality research and integrated therapeutic strategies.</div></div><div><h3>Methods</h3><div>This PRISMA-compliant review was registered on PROSPERO. We included SRs assessed oral CHFs combined with guideline recommended Standard Treatment (ST), versus ST in patients with COVID-19 patients. Primary outcomes included clinical improvement (e.g., days without ventilator support) and deterioration (e.g., new need for oxygen therapy). PubMed, Cochrane Library, Embase, Sinomed, CNKI, Wanfang, and VIP were searched from inception to July 1, 2024, for SRs (Cochrane/non-Cochrane) of RCTs reporting predefined outcomes. Secondary meta-analyses were conducted using RevMan 5.3, with methodological quality and evidence certainty assessed via AMSTAR-II and GRADE.</div></div><div><h3>Results</h3><div>Eight SRs (6860 cases) were included. Meta-analyses showed that CHF combined with ST outperformed ST alone in reducing all-cause mortality (RR = 0.27, 95 %CI [0.08–0.96], <em>P</em> = 0.04), adverse events (RR = 0.34, 95 %CI [0.20–0.59], <em>P</em> &lt; 0.0001), severe case conversion (RR = 0.33, 95 %CI [0.17–0.66], <em>P</em> = 0.002), and improving pulmonary imaging (RR = 1.28, 95 %CI [1.12–1.46], <em>P</em> = 0.0003). No significant differences were observed in clinical symptom recovery rates (cough) or recovery times (cough and fatigue). Bubble plots suggested weak to moderate effects of specific CHFs (e.g., <em>Buzhongyiqi Decoction, Maxingshigan-Weijing Decoction</em>) on viral clearance, severe case conversion, adverse events, and pulmonary imaging.</div></div><div><h3>Conclusion</h3><div>Comprehensive analyses indicated that CHFs showed good add-on effect in treating COVID-19. However, it is important to note that the overall quality of evidence in these studies is generally low, and further high-quality clinical trials are needed to validate these findings.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102440"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of the results of Reiki research","authors":"Melike Demir Doğan","doi":"10.1016/j.eujim.2025.102442","DOIUrl":"10.1016/j.eujim.2025.102442","url":null,"abstract":"<div><h3>Introduction</h3><div>This study analyses bibliometric indicators to assess global research trends on Reiki, including publication patterns and key contributing countries.</div></div><div><h3>Methods</h3><div>The publications included in Web of Science (WOS) databases between 1970 and 2024 were reviewed. The WOS database was searched using TS= “REIKI” and all WOS indexes were included. This search identified 414 studies. Among them, letters (<em>n</em> = 7), editorial materials (<em>n</em> = 19), book reviews (<em>n</em> = 9), corrections (<em>n</em> = 2), art and poetry (<em>n</em> = 1), news (<em>n</em> = 1), and retracted publications (<em>n</em> = 1) were removed. The remaining 374 articles were included in this bibliometric analysis. The R-package for bibliometric analysis (Bibliometrix) was used.</div></div><div><h3>Results</h3><div>The bibliometric analysis found that researchers published Reiki-related studies between 1983 and 2024, with a publication growth rate of 4.47 %. On average, articles were 9.5 years old and received 13 citations per document. The total number of keywords identified by the authors was 553, the number of authors in the articles was 1124 authors, the number of single-author articles was 70, the average number of publications per author was 3.5, and international co-authorships were 7.219 %. The USA, Brazil, the United Kingdom, Canada, and Turkiye were the top five countries that published on Reiki, respectively. The USA, Canada, the United Kingdom, Australia, and Turkiye were the top five countries with the most cited articles, respectively. Vitale A. is the most cited author. Journal of Alternative and Complementary Medicine is the most cited journal.</div></div><div><h3>Conclusion</h3><div>This study is the first of its kind to evaluate the articles written by researchers in the field of Reiki only. Despite the difficulties researchers experienced in the field of Reiki, the studies have increasingly been conducted in this field over the years and have been cited studies more. This study may be helpful for researchers to determine productive countries, journals, authors, and emerging trends in Reiki by providing comprehensive analyses and structured information on this subject.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102442"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical characterization of phenolic compounds by liquid chromatography-time of flight mass spectrometry and biological activities of Peltigera neckeri, Peltigera canina and Peltigera ponojensis from Türkiye","authors":"Burcu Sümer Tüzün ,&nbsp;Seyhan Oran ,&nbsp;Şule Öztürk ,&nbsp;Tuğçe Fafal ,&nbsp;Recep İlhan ,&nbsp;Bijen Kıvçak","doi":"10.1016/j.eujim.2025.102444","DOIUrl":"10.1016/j.eujim.2025.102444","url":null,"abstract":"<div><h3>Introduction</h3><div>Lichens are symbiotic associations that live in diverse environmental conditions. They produce metabolites such as carotenoids, lichen phenolics, and water-soluble phenolics. The study aims to determine the content and <em>in-vitro biological activities</em> of <em>Peltigera</em> lichens from Bursa province, which have not been previously investigated.</div></div><div><h3>Methods</h3><div>Methanol and acetone extracts were analyzed. Liquid Chromatography-Time of Flight Mass Spectrometry (LC/QTOF/MS) was used for qualitative and quantitative analysis. <em>In-vitro</em> antioxidant and tyrosinase inhibitory activities were evaluated, along with cytotoxic activity assessments.</div></div><div><h3>Results</h3><div>Zeaxanthin was identified in the acetone extract of <em>P. neckeri</em>. Vanillic acid was found to be the major component in both <em>P. canina</em> extracts, while neoxanthin was detected in the methanol extract. Evernic acid and usnic acid were also present in both extracts. Rosmarinic acid, rutin, and zeaxanthin were not detected in <em>P. ponojensis</em> extracts, whereas neoxanthin, usnic acid, and evernic acid were present. The most active extract was the methanol extract of <em>P. ponojensis</em>, with an IC₅₀ value of 23.52 ± 0.02 µg/mL for radical scavenging. No tyrosinase inhibitory activity was observed in either extract of <em>P. neckeri</em>. The most active extract was methanol extract of <em>P. ponojensis</em> with an IC₅₀ value of 30.588 ± 0.02 µg/mL. Cytotoxicity results showed no death or proliferation reduction in any tested cell lines.</div></div><div><h3>Conclusion</h3><div><em>Peltigera</em> species may serve as potential sources of antioxidants.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102444"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herb-derived compounds from Radix Salviae decoction (RSD) modulated cell death of vascular smooth muscle cells","authors":"Peizhong Liu ,&nbsp;Qingqing Liu ,&nbsp;Guofu Zhong ,&nbsp;Shunzi Zhangyun ,&nbsp;Chuangpeng Li ,&nbsp;Dawei Wang ,&nbsp;Qing Liu","doi":"10.1016/j.eujim.2025.102447","DOIUrl":"10.1016/j.eujim.2025.102447","url":null,"abstract":"<div><h3>Introduction</h3><div>Prior research has suggested that herb-derived compounds from <em>Radix Salviae</em> decoction (RSD) may have anti-inflammatory, antioxidant, antithrombotic and cardiac function improvement properties in cardiovascular system diseases. However, the efficacy and mechanism of herb-derived compounds from RSD for modulating cell death of vascular smooth muscle cells (VSMC) have yet to be investigated. This study aimed to investigate the effects of RSD in modulating cell death of vascular smooth muscle cells and elucidate the underlying mechanisms.</div></div><div><h3>Methods</h3><div>Chemical constituents were analyzed through literature and databases. Network pharmacological analysis identified targets for herb-derived compounds from RSD and cell death. A protein-protein interaction network was constructed using String, followed by GO and KEGG analyses to explore pathways affecting vascular smooth muscle cell death.</div></div><div><h3>Results</h3><div>Network pharmacological analysis identified the targets for the three compounds from RSD (Tanshinone ⅡA (DST), Santalol (TXC), and Bornyl ester (LNZ)) and three kinds of cell death (pyroptosis, autophagy and apoptosis). Large nodes such as CASP8, CASP3, TP53, JUN and BAX were observed at the center of the targets network, suggesting that they play key roles in protein interaction networks. In serum-free medium (SFM) conditions of VSMC <em>in vitro</em>, treatment with the herb–derived compounds from RSD significantly promoted pyroptosis of VSMC indicated by increased mRNA levels of GSDMD and GSDME, and the increased mRNA levels of IL-1β. These compounds also inhibited autophagy, as they reduced the expression of ATG12, and decreased the LC3-II/I ratio in VSMC; and the compounds decreased the proportion of early apoptotic cells indicated by flow cytometry. Furthermore, cytokines of IL-6 and TNF-α were notably inhibited after treatment with these compounds. For the related cell signaling transduction, the herb-derived compounds from RSD suppressed PI3K-AKT while activating the NF-κB signaling pathway.</div></div><div><h3>Conclusion</h3><div>This study reveals that treatment of nutrition-depleted VSMC with DST, TXC, and LNZ leads to the promotion of pyroptosis and downregulation of inflammatory factor expression, alongside reduction of autophagy and early apoptotic cells.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102447"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical and psychological impacts of Tai Chi on college students and the determination of optimal dose: A systematic review and meta-analysis of randomized controlled trials","authors":"Guohao Wang ,&nbsp;Yi Liu ,&nbsp;Chan Peng ,&nbsp;Ting Shen ,&nbsp;Bingbing Du ,&nbsp;Lijuan Yi","doi":"10.1016/j.eujim.2025.102450","DOIUrl":"10.1016/j.eujim.2025.102450","url":null,"abstract":"<div><h3>Introduction</h3><div>Physical inactivity among college students is a global health concern linked to adverse physical and mental health outcomes. Tai Chi, a mind-body exercise rooted in traditional Chinese medicine, has shown promise in addressing these issues through its dual physiological and psychosocial benefits. This systematic review and meta-analysis aimed to synthesize evidence on Tai Chi's effects on college students' well-being and identify optimal implementation parameters.</div></div><div><h3>Method</h3><div>The protocol for this meta-analysis has been registered with International Prospective Register of Systematic Reviews platform (PROSPERO, CRD42022380005). We systematically searched PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Wan Fang Data, Chinese Scientific Journal Database (VIP), and Chinese Biomedical Medicine Database (CBM) databases from inception to July 2022 (updated January 2024) for randomized controlled trials (RCTs) evaluating Tai Chi's physical/psychological impacts on college students. Two reviewers independently screened studies, extracted data, and assessed bias risk using Cochrane Handbook 5.2. Meta-analyses were performed in RevMan 5.4, with subgroup analyses to determine optimal exercise parameters.</div></div><div><h3>Results</h3><div>We included a total of 26 trials with 1806 participants. The results of the meta-analysis demonstrated that Tai Chi exerts a positive influence on the physical and mental well-being of college students. Specifically, it led to an enhancement in vital capacity (MD=41.96; 95 % CI, 31.49 to 52.44), and a reduction in anxiety (SMD= -0.22; 95 % CI, -0.37 to -0.08;) and depression symptoms (SMD= -0.17; 95 % CI, -0.30 to -0.04). Subgroup analysis revealed optimal parameters for depression (&gt;12 weeks, ≥4 sessions/week, each &gt;50 min, total &gt;150 min/week) and anxiety (&gt;12 weeks, ≥4 sessions/week, each 30–50 min, total &gt;150 min/week).</div></div><div><h3>Conclusion</h3><div>Tai Chi exhibits meaningful benefits for respiratory function and mental health in college students, though effects on other physiological markers remain inconclusive. While these evidence-based parameters provide practical guidance, methodological limitations (e.g., regional bias, heterogeneous interventions) necessitate cautious interpretation. Future trials should prioritize standardized protocols and long-term follow-up to optimize Tai Chi's role in campus wellness programs.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102450"},"PeriodicalIF":1.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of auricular acupressure on sexual functioning among postmenopausal women: A randomized sham controlled trial","authors":"Zainab Alimoradi ,&nbsp;Zohreh Hosseini Marznaki ,&nbsp;Mohammad Hossein Hakimi ,&nbsp;Terry Oleson ,&nbsp;Mark D. Griffiths","doi":"10.1016/j.eujim.2025.102451","DOIUrl":"10.1016/j.eujim.2025.102451","url":null,"abstract":"<div><h3>Introduction</h3><div>Sexual dysfunction is a common complaint of postmenopausal women. The present study investigated the effect of ear acupressure on sexual functioning (the primary outcome) and sexual distress (the secondary outcome) among postmenopausal women.</div></div><div><h3>Methods</h3><div>A randomized, sham-controlled triple-blinded trial was conducted from June 2022 to January 2023 among postmenopausal women recruited from urban comprehensive health centers in Qazvin, Iran. Ninety postmenopausal women were randomly assigned (1:1) to auricular acupressure or sham control group using a balanced block randomization method. The intervention was 10 sessions of ear acupressure (at four-day intervals) using adhesives containing vaccaria seeds. The sham intervention was identical except for the use of special non-latex adhesives but without the vaccaria seeds. The Female Sexual Function Index (FSFI), Arizona Sexual Experience Scale (ASEX), and Female Sexual Distress Scale (FSDS) were completed by participants three times during the study: before intervention, one month after intervention, and two months after intervention.</div></div><div><h3>Results</h3><div>Auricular acupressure significantly increased the mean score on the FSFI in the intervention group compared to the sham group (adjusted mean difference of 5.12 [95 % CI: 3.39; 6.85] in first follow-up, and 10.17 [95 % CI: 7.71; 12.63]) in second follow-up. There was a significant decrease in the mean score on the ASEX (decreased scores indicate better sexual experience) and FSD in the intervention group compared to the sham group in first and second follow-up. These changes were also clinically significant. No adverse events were reported during the intervention or the follow-ups.</div></div><div><h3>Conclusion</h3><div>Among postmenopausal women, auricular acupressure appears to be an effective intervention in improving sexual functioning, as well as reducing sexual distress.</div></div><div><h3>Trial registration</h3><div>The trial was registered prospectively in 2022–04–13 (code IRCT20180218038789N6) in the Clinical Trial Registration Center of Iran.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102451"},"PeriodicalIF":1.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin for the prevention and treatment of cataracts: A systematic review of preclinical studies and potential therapeutic mechanisms","authors":"Mahdie Hajimonfarednejad ,&nbsp;Seyede Maryam Najibi ,&nbsp;Fatemeh Sadat Hasheminasab","doi":"10.1016/j.eujim.2025.102448","DOIUrl":"10.1016/j.eujim.2025.102448","url":null,"abstract":"<div><h3>Introduction</h3><div>Cataract is one of the leading causes of blindness worldwide. Recent research has established that oxidative stress and free radical damage significantly contribute to the development of cataracts. Studies focused on cataract prevention and treatment have investigated curcumin, an antioxidant derived from plants. The present systematic review aims to provide an overview of the current evidence regarding the effectiveness of curcumin in the prevention and treatment of cataracts, as well as the underlying mechanisms of its action, based on preclinical studies. Curcumin (diarylheptanoid) is an antioxidant derived from the rhizome of <em>Curcuma longa</em>.</div></div><div><h3>Methods</h3><div>Studies indexed in Google Scholar, PubMed, Scopus, and Web of Science were searched for from publication dates until October 10, 2024. The search strategy utilized keywords related to cataracts and curcumin. In vivo, in vitro, and trials published in English that assessed the therapeutic or preventive potential of curcumin against cataracts were eligible for inclusion. Information was gathered on the types of studies, cell types or animal models used, the aims of the studies, interventions, primary outcomes, and whether curcumin could help in preventing the development of cataracts or improving the condition, as well as the reported mechanisms of action. SYRCLE's risk of bias tool was used to identify potential biases in animal research.</div></div><div><h3>Results</h3><div>Out of 206 papers screened, only 17 papers (nine in vivo studies, seven in vitro studies and one both vivo-in vitro study) met the selection criteria for the current review. All included literature confirmed the anticataract property of curcumin. They showed that the cataract prevention capability of curcumin was related high on the basis of lipid peroxidation inhibition and stimulation of antioxidant enzymes. No human studies were found that investigated the anticataractogenic role of curcumin.</div></div><div><h3>Conclusion</h3><div>Curcumin has the potential to serve as a therapeutic agent for the prevention and treatment of cataracts due to its antioxidant activity. However, to fully harness the clinical benefits of this compound, issues related to its bioavailability must be addressed. To realize the full potential of curcumin as an effective strategy against cataracts, conducting clinical trials is essential.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102448"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing moxibustion strategies in rheumatoid arthritis: A systematic review and network meta-analysis","authors":"Jiamin Wen ,&nbsp;Jiatian Ma ,&nbsp;Qiao Xiao ,&nbsp;Tingting Liu ,&nbsp;Zhiling Sun","doi":"10.1016/j.eujim.2025.102449","DOIUrl":"10.1016/j.eujim.2025.102449","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) is a highly prevalent chronic autoimmune disease worldwide. Moxibustion has increasingly been used in clinical practice as an effective treatment for RA. However, more comprehensive evidence is needed to determine optimal moxibustion strategies for RA management and guide clinical interventions.</div></div><div><h3>Methods</h3><div>This review conducted a literature search across eight databases, including PubMed, Embase, Web of Science, Cochrane Library, VIP, CBM, Wanfang Database, and CNKI. The Cochrane Risk of Bias tool 2 was used to assess the quality of the selected studies. Network meta-analysis (NMA) was conducted using R Studio 4.2.2 and STATA 17.0.</div></div><div><h3>Results</h3><div>A total of 78 clinical trials with 5896 participants were included. The relative efficacy of nine moxibustion therapies was assessed. NMA data revealed that compared with conventional therapy (CVT, including Disease-modifying Antirheumatic Drugs, Nonsteroidal Anti-inflammatory Drugs, and glucocorticoids), heat-sensitive moxibustion plus CVT showed promising effects for clinical response (RR = 1.45, 95 % CI: 1.08, 2.06) and disease activity score 28 (DAS-28; mean difference [MD] = −0.98, 95 % CI: −1.81, −0.15). Moxa cone moxibustion (MCM) plus CVT was more effective than suspending moxibustion plus CVT in DAS-28 (MD = −0.48, 95 % CI: −0.83, −0.09). For the visual analog scale, MCM plus CVT was the most effective (MD = −1.59, 95 % CI: −2.08, −1.11), more effective than warm needle moxibustion (WNM) plus CVT (MD = −0.93, 95 % CI: −1.81, −0.05) and direct moxibustion plus CVT (MD = −1.49, 95 % CI: −2.81, −0.19). Indirect moxibustion (IM) plus CVT was most effective in reducing morning stiffness time (MD = −22.76, 95 % CI: −36.31, −7.23). WNM plus CVT and governor vessel moxibustion (GVM) plus CVT showed greater effects in reducing swollen joint count (MD = −2.37, 95 % CI: −3.23, −1.54) and lowering rheumatoid factor (MD = −0.68, 95 % CI: −1.58, 0.22). In reducing C-reactive protein, IM plus CVT was most effective (MD = −6.60, 95 % CI: −9.55, −3.95). GVM plus CVT had the lowest adverse reaction rate (3.33 %).</div></div><div><h3>Conclusion</h3><div>This NMA provides robust evidence supporting the combination of multiple moxibustion therapies with traditional RA treatments. Moxibustion may alleviate various RA symptoms. However, longer-term, high-quality, reproducible, multicenter randomized controlled trials with larger sample sizes are necessary to confirm these results and establish optimal treatment strategies.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102449"},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence construction of traditional Chinese medicine injections for Group 3 pulmonary hypertension: A Bayesian network meta-analysis of 70 randomized controlled trials","authors":"Zhaohui Ding ,&nbsp;Xunxun Yuan ,&nbsp;Junfeng Fan ,&nbsp;Fangfang Chao ,&nbsp;Jia Xiao ,&nbsp;Huie Luo ,&nbsp;Hanrong Xue ,&nbsp;Lihua Wang","doi":"10.1016/j.eujim.2025.102446","DOIUrl":"10.1016/j.eujim.2025.102446","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese medicine (TCM) injections have potential in treating primary conditions associated with Group 3 pulmonary hypertension (G3PH) and preventing its progression. However, the optimal intervention for specific outcomes remains unclear.</div></div><div><h3>Methods</h3><div>Randomized controlled trials (RCTs) were identified from eight databases up to December 26, 2024. The Risk of Bias 2 (RoB 2) tool was employed to evaluate the risk of bias of the included RCTs. Bayesian network meta-analyses were conducted to assess the effectiveness of TCM injections for G3PH. The effectiveness and safety of TCM injections were ranked based on the surface under the cumulative ranking curve (SUCRA).</div></div><div><h3>Results</h3><div>Seventy RCTs were included, involving 17 TCM injections and 6148 patients. According to the RoB 2 assessment, 65 and 5 RCTs were classified as having “some concerns” or “high” risk of bias, respectively. Bayesian network meta-analyses indicated that Shenmai injection, Shuxuening injection, Xinmailong injection, and Danhong injection ranked highest for improving response rates based on cardiac function (SUCRA: 89.2 %), partial pressure of oxygen (PaO₂) (SUCRA: 97.0 %), partial pressure of carbon dioxide (PaCO₂) (SUCRA: 89.7 %), and blood oxygen saturation (SaO₂) (SUCRA: 99.0 %), respectively. Honghua injection showed the strongest effects in reducing mean pulmonary arterial pressure (mPAP) (SUCRA: 88.0 %) and increasing forced expiratory volume in one second as a percentage of prediction (FEV₁ % pred) (SUCRA: 87.7 %). All reported adverse events were mild.</div></div><div><h3>Conclusions</h3><div>TCM injections are generally effective and safe complementary therapies for G3PH. Shenmai injection, Honghua injection, Shuxuening injection, Xinmailong injection, and Danhong injection emerged as the most effective options for improving various outcomes, including response rate, mPAP, FEV₁ % pred, PaO₂, PaCO₂, and SaO₂. However, the evidence quality ranges from moderate to very low due to risks of bias, imprecision, and heterogeneity among the included RCTs.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102446"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}