European Journal of Integrative Medicine最新文献

{"title":"Phytochemical characterization of phenolic compounds by liquid chromatography-time of flight mass spectrometry and biological activities of Peltigera neckeri, Peltigera canina and Peltigera ponojensis from Türkiye","authors":"Burcu Sümer Tüzün ,&nbsp;Seyhan Oran ,&nbsp;Şule Öztürk ,&nbsp;Tuğçe Fafal ,&nbsp;Recep İlhan ,&nbsp;Bijen Kıvçak","doi":"10.1016/j.eujim.2025.102444","DOIUrl":"10.1016/j.eujim.2025.102444","url":null,"abstract":"<div><h3>Introduction</h3><div>Lichens are symbiotic associations that live in diverse environmental conditions. They produce metabolites such as carotenoids, lichen phenolics, and water-soluble phenolics. The study aims to determine the content and <em>in-vitro biological activities</em> of <em>Peltigera</em> lichens from Bursa province, which have not been previously investigated.</div></div><div><h3>Methods</h3><div>Methanol and acetone extracts were analyzed. Liquid Chromatography-Time of Flight Mass Spectrometry (LC/QTOF/MS) was used for qualitative and quantitative analysis. <em>In-vitro</em> antioxidant and tyrosinase inhibitory activities were evaluated, along with cytotoxic activity assessments.</div></div><div><h3>Results</h3><div>Zeaxanthin was identified in the acetone extract of <em>P. neckeri</em>. Vanillic acid was found to be the major component in both <em>P. canina</em> extracts, while neoxanthin was detected in the methanol extract. Evernic acid and usnic acid were also present in both extracts. Rosmarinic acid, rutin, and zeaxanthin were not detected in <em>P. ponojensis</em> extracts, whereas neoxanthin, usnic acid, and evernic acid were present. The most active extract was the methanol extract of <em>P. ponojensis</em>, with an IC₅₀ value of 23.52 ± 0.02 µg/mL for radical scavenging. No tyrosinase inhibitory activity was observed in either extract of <em>P. neckeri</em>. The most active extract was methanol extract of <em>P. ponojensis</em> with an IC₅₀ value of 30.588 ± 0.02 µg/mL. Cytotoxicity results showed no death or proliferation reduction in any tested cell lines.</div></div><div><h3>Conclusion</h3><div><em>Peltigera</em> species may serve as potential sources of antioxidants.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102444"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herb-derived compounds from Radix Salviae decoction (RSD) modulated cell death of vascular smooth muscle cells","authors":"Peizhong Liu ,&nbsp;Qingqing Liu ,&nbsp;Guofu Zhong ,&nbsp;Shunzi Zhangyun ,&nbsp;Chuangpeng Li ,&nbsp;Dawei Wang ,&nbsp;Qing Liu","doi":"10.1016/j.eujim.2025.102447","DOIUrl":"10.1016/j.eujim.2025.102447","url":null,"abstract":"<div><h3>Introduction</h3><div>Prior research has suggested that herb-derived compounds from <em>Radix Salviae</em> decoction (RSD) may have anti-inflammatory, antioxidant, antithrombotic and cardiac function improvement properties in cardiovascular system diseases. However, the efficacy and mechanism of herb-derived compounds from RSD for modulating cell death of vascular smooth muscle cells (VSMC) have yet to be investigated. This study aimed to investigate the effects of RSD in modulating cell death of vascular smooth muscle cells and elucidate the underlying mechanisms.</div></div><div><h3>Methods</h3><div>Chemical constituents were analyzed through literature and databases. Network pharmacological analysis identified targets for herb-derived compounds from RSD and cell death. A protein-protein interaction network was constructed using String, followed by GO and KEGG analyses to explore pathways affecting vascular smooth muscle cell death.</div></div><div><h3>Results</h3><div>Network pharmacological analysis identified the targets for the three compounds from RSD (Tanshinone ⅡA (DST), Santalol (TXC), and Bornyl ester (LNZ)) and three kinds of cell death (pyroptosis, autophagy and apoptosis). Large nodes such as CASP8, CASP3, TP53, JUN and BAX were observed at the center of the targets network, suggesting that they play key roles in protein interaction networks. In serum-free medium (SFM) conditions of VSMC <em>in vitro</em>, treatment with the herb–derived compounds from RSD significantly promoted pyroptosis of VSMC indicated by increased mRNA levels of GSDMD and GSDME, and the increased mRNA levels of IL-1β. These compounds also inhibited autophagy, as they reduced the expression of ATG12, and decreased the LC3-II/I ratio in VSMC; and the compounds decreased the proportion of early apoptotic cells indicated by flow cytometry. Furthermore, cytokines of IL-6 and TNF-α were notably inhibited after treatment with these compounds. For the related cell signaling transduction, the herb-derived compounds from RSD suppressed PI3K-AKT while activating the NF-κB signaling pathway.</div></div><div><h3>Conclusion</h3><div>This study reveals that treatment of nutrition-depleted VSMC with DST, TXC, and LNZ leads to the promotion of pyroptosis and downregulation of inflammatory factor expression, alongside reduction of autophagy and early apoptotic cells.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102447"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of auricular acupressure on sexual functioning among postmenopausal women: A randomized sham controlled trial","authors":"Zainab Alimoradi ,&nbsp;Zohreh Hosseini Marznaki ,&nbsp;Mohammad Hossein Hakimi ,&nbsp;Terry Oleson ,&nbsp;Mark D. Griffiths","doi":"10.1016/j.eujim.2025.102451","DOIUrl":"10.1016/j.eujim.2025.102451","url":null,"abstract":"<div><h3>Introduction</h3><div>Sexual dysfunction is a common complaint of postmenopausal women. The present study investigated the effect of ear acupressure on sexual functioning (the primary outcome) and sexual distress (the secondary outcome) among postmenopausal women.</div></div><div><h3>Methods</h3><div>A randomized, sham-controlled triple-blinded trial was conducted from June 2022 to January 2023 among postmenopausal women recruited from urban comprehensive health centers in Qazvin, Iran. Ninety postmenopausal women were randomly assigned (1:1) to auricular acupressure or sham control group using a balanced block randomization method. The intervention was 10 sessions of ear acupressure (at four-day intervals) using adhesives containing vaccaria seeds. The sham intervention was identical except for the use of special non-latex adhesives but without the vaccaria seeds. The Female Sexual Function Index (FSFI), Arizona Sexual Experience Scale (ASEX), and Female Sexual Distress Scale (FSDS) were completed by participants three times during the study: before intervention, one month after intervention, and two months after intervention.</div></div><div><h3>Results</h3><div>Auricular acupressure significantly increased the mean score on the FSFI in the intervention group compared to the sham group (adjusted mean difference of 5.12 [95 % CI: 3.39; 6.85] in first follow-up, and 10.17 [95 % CI: 7.71; 12.63]) in second follow-up. There was a significant decrease in the mean score on the ASEX (decreased scores indicate better sexual experience) and FSD in the intervention group compared to the sham group in first and second follow-up. These changes were also clinically significant. No adverse events were reported during the intervention or the follow-ups.</div></div><div><h3>Conclusion</h3><div>Among postmenopausal women, auricular acupressure appears to be an effective intervention in improving sexual functioning, as well as reducing sexual distress.</div></div><div><h3>Trial registration</h3><div>The trial was registered prospectively in 2022–04–13 (code IRCT20180218038789N6) in the Clinical Trial Registration Center of Iran.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102451"},"PeriodicalIF":1.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical and psychological impacts of Tai Chi on college students and the determination of optimal dose: A systematic review and meta-analysis of randomized controlled trials","authors":"Guohao Wang ,&nbsp;Yi Liu ,&nbsp;Chan Peng ,&nbsp;Ting Shen ,&nbsp;Bingbing Du ,&nbsp;Lijuan Yi","doi":"10.1016/j.eujim.2025.102450","DOIUrl":"10.1016/j.eujim.2025.102450","url":null,"abstract":"<div><h3>Introduction</h3><div>Physical inactivity among college students is a global health concern linked to adverse physical and mental health outcomes. Tai Chi, a mind-body exercise rooted in traditional Chinese medicine, has shown promise in addressing these issues through its dual physiological and psychosocial benefits. This systematic review and meta-analysis aimed to synthesize evidence on Tai Chi's effects on college students' well-being and identify optimal implementation parameters.</div></div><div><h3>Method</h3><div>The protocol for this meta-analysis has been registered with International Prospective Register of Systematic Reviews platform (PROSPERO, CRD42022380005). We systematically searched PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Wan Fang Data, Chinese Scientific Journal Database (VIP), and Chinese Biomedical Medicine Database (CBM) databases from inception to July 2022 (updated January 2024) for randomized controlled trials (RCTs) evaluating Tai Chi's physical/psychological impacts on college students. Two reviewers independently screened studies, extracted data, and assessed bias risk using Cochrane Handbook 5.2. Meta-analyses were performed in RevMan 5.4, with subgroup analyses to determine optimal exercise parameters.</div></div><div><h3>Results</h3><div>We included a total of 26 trials with 1806 participants. The results of the meta-analysis demonstrated that Tai Chi exerts a positive influence on the physical and mental well-being of college students. Specifically, it led to an enhancement in vital capacity (MD=41.96; 95 % CI, 31.49 to 52.44), and a reduction in anxiety (SMD= -0.22; 95 % CI, -0.37 to -0.08;) and depression symptoms (SMD= -0.17; 95 % CI, -0.30 to -0.04). Subgroup analysis revealed optimal parameters for depression (&gt;12 weeks, ≥4 sessions/week, each &gt;50 min, total &gt;150 min/week) and anxiety (&gt;12 weeks, ≥4 sessions/week, each 30–50 min, total &gt;150 min/week).</div></div><div><h3>Conclusion</h3><div>Tai Chi exhibits meaningful benefits for respiratory function and mental health in college students, though effects on other physiological markers remain inconclusive. While these evidence-based parameters provide practical guidance, methodological limitations (e.g., regional bias, heterogeneous interventions) necessitate cautious interpretation. Future trials should prioritize standardized protocols and long-term follow-up to optimize Tai Chi's role in campus wellness programs.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102450"},"PeriodicalIF":1.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin for the prevention and treatment of cataracts: A systematic review of preclinical studies and potential therapeutic mechanisms","authors":"Mahdie Hajimonfarednejad ,&nbsp;Seyede Maryam Najibi ,&nbsp;Fatemeh Sadat Hasheminasab","doi":"10.1016/j.eujim.2025.102448","DOIUrl":"10.1016/j.eujim.2025.102448","url":null,"abstract":"<div><h3>Introduction</h3><div>Cataract is one of the leading causes of blindness worldwide. Recent research has established that oxidative stress and free radical damage significantly contribute to the development of cataracts. Studies focused on cataract prevention and treatment have investigated curcumin, an antioxidant derived from plants. The present systematic review aims to provide an overview of the current evidence regarding the effectiveness of curcumin in the prevention and treatment of cataracts, as well as the underlying mechanisms of its action, based on preclinical studies. Curcumin (diarylheptanoid) is an antioxidant derived from the rhizome of <em>Curcuma longa</em>.</div></div><div><h3>Methods</h3><div>Studies indexed in Google Scholar, PubMed, Scopus, and Web of Science were searched for from publication dates until October 10, 2024. The search strategy utilized keywords related to cataracts and curcumin. In vivo, in vitro, and trials published in English that assessed the therapeutic or preventive potential of curcumin against cataracts were eligible for inclusion. Information was gathered on the types of studies, cell types or animal models used, the aims of the studies, interventions, primary outcomes, and whether curcumin could help in preventing the development of cataracts or improving the condition, as well as the reported mechanisms of action. SYRCLE's risk of bias tool was used to identify potential biases in animal research.</div></div><div><h3>Results</h3><div>Out of 206 papers screened, only 17 papers (nine in vivo studies, seven in vitro studies and one both vivo-in vitro study) met the selection criteria for the current review. All included literature confirmed the anticataract property of curcumin. They showed that the cataract prevention capability of curcumin was related high on the basis of lipid peroxidation inhibition and stimulation of antioxidant enzymes. No human studies were found that investigated the anticataractogenic role of curcumin.</div></div><div><h3>Conclusion</h3><div>Curcumin has the potential to serve as a therapeutic agent for the prevention and treatment of cataracts due to its antioxidant activity. However, to fully harness the clinical benefits of this compound, issues related to its bioavailability must be addressed. To realize the full potential of curcumin as an effective strategy against cataracts, conducting clinical trials is essential.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102448"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing moxibustion strategies in rheumatoid arthritis: A systematic review and network meta-analysis","authors":"Jiamin Wen ,&nbsp;Jiatian Ma ,&nbsp;Qiao Xiao ,&nbsp;Tingting Liu ,&nbsp;Zhiling Sun","doi":"10.1016/j.eujim.2025.102449","DOIUrl":"10.1016/j.eujim.2025.102449","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) is a highly prevalent chronic autoimmune disease worldwide. Moxibustion has increasingly been used in clinical practice as an effective treatment for RA. However, more comprehensive evidence is needed to determine optimal moxibustion strategies for RA management and guide clinical interventions.</div></div><div><h3>Methods</h3><div>This review conducted a literature search across eight databases, including PubMed, Embase, Web of Science, Cochrane Library, VIP, CBM, Wanfang Database, and CNKI. The Cochrane Risk of Bias tool 2 was used to assess the quality of the selected studies. Network meta-analysis (NMA) was conducted using R Studio 4.2.2 and STATA 17.0.</div></div><div><h3>Results</h3><div>A total of 78 clinical trials with 5896 participants were included. The relative efficacy of nine moxibustion therapies was assessed. NMA data revealed that compared with conventional therapy (CVT, including Disease-modifying Antirheumatic Drugs, Nonsteroidal Anti-inflammatory Drugs, and glucocorticoids), heat-sensitive moxibustion plus CVT showed promising effects for clinical response (RR = 1.45, 95 % CI: 1.08, 2.06) and disease activity score 28 (DAS-28; mean difference [MD] = −0.98, 95 % CI: −1.81, −0.15). Moxa cone moxibustion (MCM) plus CVT was more effective than suspending moxibustion plus CVT in DAS-28 (MD = −0.48, 95 % CI: −0.83, −0.09). For the visual analog scale, MCM plus CVT was the most effective (MD = −1.59, 95 % CI: −2.08, −1.11), more effective than warm needle moxibustion (WNM) plus CVT (MD = −0.93, 95 % CI: −1.81, −0.05) and direct moxibustion plus CVT (MD = −1.49, 95 % CI: −2.81, −0.19). Indirect moxibustion (IM) plus CVT was most effective in reducing morning stiffness time (MD = −22.76, 95 % CI: −36.31, −7.23). WNM plus CVT and governor vessel moxibustion (GVM) plus CVT showed greater effects in reducing swollen joint count (MD = −2.37, 95 % CI: −3.23, −1.54) and lowering rheumatoid factor (MD = −0.68, 95 % CI: −1.58, 0.22). In reducing C-reactive protein, IM plus CVT was most effective (MD = −6.60, 95 % CI: −9.55, −3.95). GVM plus CVT had the lowest adverse reaction rate (3.33 %).</div></div><div><h3>Conclusion</h3><div>This NMA provides robust evidence supporting the combination of multiple moxibustion therapies with traditional RA treatments. Moxibustion may alleviate various RA symptoms. However, longer-term, high-quality, reproducible, multicenter randomized controlled trials with larger sample sizes are necessary to confirm these results and establish optimal treatment strategies.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102449"},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence construction of traditional Chinese medicine injections for Group 3 pulmonary hypertension: A Bayesian network meta-analysis of 70 randomized controlled trials","authors":"Zhaohui Ding ,&nbsp;Xunxun Yuan ,&nbsp;Junfeng Fan ,&nbsp;Fangfang Chao ,&nbsp;Jia Xiao ,&nbsp;Huie Luo ,&nbsp;Hanrong Xue ,&nbsp;Lihua Wang","doi":"10.1016/j.eujim.2025.102446","DOIUrl":"10.1016/j.eujim.2025.102446","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese medicine (TCM) injections have potential in treating primary conditions associated with Group 3 pulmonary hypertension (G3PH) and preventing its progression. However, the optimal intervention for specific outcomes remains unclear.</div></div><div><h3>Methods</h3><div>Randomized controlled trials (RCTs) were identified from eight databases up to December 26, 2024. The Risk of Bias 2 (RoB 2) tool was employed to evaluate the risk of bias of the included RCTs. Bayesian network meta-analyses were conducted to assess the effectiveness of TCM injections for G3PH. The effectiveness and safety of TCM injections were ranked based on the surface under the cumulative ranking curve (SUCRA).</div></div><div><h3>Results</h3><div>Seventy RCTs were included, involving 17 TCM injections and 6148 patients. According to the RoB 2 assessment, 65 and 5 RCTs were classified as having “some concerns” or “high” risk of bias, respectively. Bayesian network meta-analyses indicated that Shenmai injection, Shuxuening injection, Xinmailong injection, and Danhong injection ranked highest for improving response rates based on cardiac function (SUCRA: 89.2 %), partial pressure of oxygen (PaO₂) (SUCRA: 97.0 %), partial pressure of carbon dioxide (PaCO₂) (SUCRA: 89.7 %), and blood oxygen saturation (SaO₂) (SUCRA: 99.0 %), respectively. Honghua injection showed the strongest effects in reducing mean pulmonary arterial pressure (mPAP) (SUCRA: 88.0 %) and increasing forced expiratory volume in one second as a percentage of prediction (FEV₁ % pred) (SUCRA: 87.7 %). All reported adverse events were mild.</div></div><div><h3>Conclusions</h3><div>TCM injections are generally effective and safe complementary therapies for G3PH. Shenmai injection, Honghua injection, Shuxuening injection, Xinmailong injection, and Danhong injection emerged as the most effective options for improving various outcomes, including response rate, mPAP, FEV₁ % pred, PaO₂, PaCO₂, and SaO₂. However, the evidence quality ranges from moderate to very low due to risks of bias, imprecision, and heterogeneity among the included RCTs.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"76 ","pages":"Article 102446"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary analyses of Traditional East Asian Medicine (TEAM) case report and clinical registry data on pain: A study protocol","authors":"Brigitte Linder ,&nbsp;Nicholas Lowe ,&nbsp;Mike Armour ,&nbsp;Belinda J. Anderson ,&nbsp;Lisa Conboy ,&nbsp;Lisa Taylor-Swanson ,&nbsp;Sandro Graca ,&nbsp;Rodney Dutton ,&nbsp;Kathleen Lumiere","doi":"10.1016/j.eujim.2025.102437","DOIUrl":"10.1016/j.eujim.2025.102437","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional East Asian Medicine (TEAM) relies heavily on case reports for clinical decision-making. However, methods for analyzing data from multiple case reports are currently underdeveloped. This protocol will outline novel methods for secondary analyses of TEAM case reports and clinical registry data focused on pain to inform practice-based research.</div></div><div><h3>Methods</h3><div>We will use a concurrent triangulation mixed methods design to analyze data from 12 case reports and 130 clinical registry records, meeting the requirements of the CARE guidelines and focusing on TEAM treatments for pain. Quantitative analysis will include descriptive statistics, pairwise <em>t</em>-tests, and responder analysis. Qualitative analysis will employ thematic analysis with both deductive and inductive approaches. Data will be standardized using ICPC-2 and ICD-11 Traditional Medicine codes. Key focus areas include practitioner diagnosis, clinical reasoning, patient outcomes, and self-care behaviors.</div></div><div><h3>Discussion</h3><div>Anticipated outcomes include refined methodologies for case report and clinical registry data analysis, insights into TEAM clinical practice patterns, and identification of complex system phenomena within TEAM frameworks.</div></div><div><h3>Conclusion</h3><div>This project aims to address research gaps in modelling case data analysis methodologies for TEAM, potentially enhancing the rigor, validity, and applicability of practice-based research, informing clinical trial design, and contributing to better patient-centered care.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"75 ","pages":"Article 102437"},"PeriodicalIF":1.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of scalp acupuncture therapy combined with training on limb movement disorders after stroke: A systematic review and meta-analysis","authors":"Yenan Tian ,&nbsp;Peizhen Zhao ,&nbsp;Yongjun Peng","doi":"10.1016/j.eujim.2025.102432","DOIUrl":"10.1016/j.eujim.2025.102432","url":null,"abstract":"<div><h3>Introduction</h3><div>Stroke patients often suffer from different degrees of disability, among which limb movement disorders (LMDs) are the most prevalent. Scalp acupuncture (SA) therapy combined with training has been widely used for LMD treatment after stroke. Whether SA therapy combined with training is superior to monotherapy or other therapies remains unknown. This review aimed to evaluate the effectiveness and safety of SA therapy combined with training for LMDs after stroke.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, Web of Science, and Cochrane Library databases were thoroughly searched for studies from inception to November 23, 2024. Fugl-Meyer Assessment (FMA), Modified Ashworth Scale (MAS), Berg Balance Scale (BBS), and Modified Barthel Index (MBI) were used to evaluate the effectiveness of SA therapy combined with training in treating LMDs after stroke. Weighted mean differences (WMDs) were calculated.</div></div><div><h3>Results</h3><div>A total of 4345 records were initially identified, and 26 studies were finally included. Compared to simple training, SA therapy combined with training had significant effects in the total score of FMA (WMD= 10.01, 95 %CI= 2.24, 17.78), the upper-extremity score of FMA (WMD= 6.35, 95 %CI=4.11, 8.59), the lower-extremity score of FMA (WMD= 2.69, 95 %CI= 1.49, 3.90), MAS (WMD= -0.47, 95 %CI= -0.72, -0.22), BBS (WMD= 3.52, 95 %CI= 0.55, 6.48), and MBI (WMD= 7.72, 95 %CI= 4.97, 9.56). No significant difference was found in adverse events (RR= 6.97, 95 %CI= 2.10, 23.11, <em>P</em> = 0.33). More significant effects in FMA-L and MAS were revealed after 12 weeks of treatment (all P _interaction&lt;0.01).</div></div><div><h3>Conclusion</h3><div>SA therapy combined with training can significantly improve FMA, MAS, BBS, and MBI to enhance limb function, with favorable safety profiles. 12 weeks of SA therapy combined with training often yields better improvements in lower limb motor function and limb spasticity. More RCTs of higher quality are needed to provide reliable support for these conclusions.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"74 ","pages":"Article 102432"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of obesity-related parameters and dietary habits on Chinese medicine body constitutions: A mediation analysis based on Taiwan Biobank Research Database","authors":"Ping-Ho Chen ,&nbsp;Su-Chen Fang ,&nbsp;Shu-fen Shen ,&nbsp;Chen-Jung Chen ,&nbsp;Wan-Ling Lin ,&nbsp;Sheng-Miauh Huang","doi":"10.1016/j.eujim.2025.102431","DOIUrl":"10.1016/j.eujim.2025.102431","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Chinese medicine (TCM) theory believes that diet is very important in changing body constitution and preventing diseases because food is similar to medicine. This study aimed to explore the effects of obesity-related parameters and dietary habits on TCM body constitution in Taiwanese people.</div></div><div><h3>Methods</h3><div>This study applied an observational cross-sectional design. Individuals were selected from the Taiwan Biobank Research Database. The body constitution questionnaire (BCQ) and food frequency questionnaire (FFQ) were administered. Yin deficiency, yang deficiency, and stasis in TCM were assessed by BCQ. Obesity-related parameters were defined as body weight, body fat, and body mass index (BMI). Multiple linear regression and mediation analyses were conducted.</div></div><div><h3>Results</h3><div>A total of 16,790 individuals were enrolled in the study. Individuals with higher FFQ scores and BMI had better yang deficiency, yin deficiency, and stasis patterns. Those with higher body weight and body fat had poor yang deficiency, yin deficiency, and stasis patterns. After adjusting for potential confounders, all obesity-related parameters partially mediated the association between the FFQ and yang deficiency or stasis patterns. Only body weight partially mediated the association between the FFQ and yin deficiency patterns.</div></div><div><h3>Conclusion</h3><div>Dietary habits and obesity-related parameters have direct effects on TCM body constitutions. Healthy dietary habits have an indirect effect on TCM body constitutions through obesity-related parameters, especially for yang deficiency and stasis patterns. Further studies are needed to confirm and understand the potential mechanisms, including innate physiological and environmental factors, underlying these findings.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"74 ","pages":"Article 102431"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}