European Journal of Integrative Medicine最新文献

{"title":"Meta-analysis and trial sequential analysis of Huaiqihuang granules in treatment of cough variant asthma in pediatrics","authors":"Qiaoling Li,&nbsp;Jing Peng,&nbsp;Linhui Liu","doi":"10.1016/j.eujim.2025.102511","DOIUrl":"10.1016/j.eujim.2025.102511","url":null,"abstract":"<div><h3>Introduction</h3><div>Many individuals with cough variant asthma (CVA) utilize Huaiqihuang granules to alleviate symptoms. However, there is a lack of systematic reviews investigating its efficacy and safety for CVA.</div></div><div><h3>Methods</h3><div>A computer-based retrieval of various databases was conducted to search for randomized controlled trials (RCTs) on the treatment of CVA in children using Huaiqihuang granules combined with Western medicine. The search encompassed eight databases, including China National Knowledge Infrastructure (CNKI), Wangfang, VIP (VIP Information Co.Ltd.), PubMed, Web of Science, The Cochrane Library, Embase, and Sinomed database, and covered literature up to April 2025. Articles were screened and selected based on predefined inclusion and exclusion criteria. The quality of the included articles was assessed, followed by a meta-analysis using RevMan5.3. The quality of evidence was graded using the Grade of Recommendations Assessment, Development, and Evaluation (GRADE) system. Additionally, trial sequential analysis (TSA) was performed using TSA 0.9.5.10 beta software.</div></div><div><h3>Results</h3><div>A total of 17 RCTs were included in the analysis, encompassing a total sample size of 1,742 patients. Results showed that the combination of Huaiqihuang granules with conventional Western medicine significantly enhanced clinical efficacy and reduced recurrence rates compared to Western medicine alone. This combination also improved immune parameters, including CD4+/CD8+, and modulated inflammatory markers such as inflammatory factors interleukin-4 (IL-4) and interferon-gamma (IFN-γ), while restoring immunoglobulin levels (IgA, IgE, IgG). Additionally, it improved pulmonary function indices, including FEV1, FEV1/FVC and PEF. No significant differences were observed in the incidence of adverse reactions between the two groups. TSA demonstrated that the total effective rate curve surpassed both the traditional and TSA boundaries, corroborating the clinical efficacy. According to the GRADE assessment, outcomes related to treatment efficacy, recurrence rate, IFN-γ, CD4+, and incidence of adverse reactions were rated as moderate-quality evidence, whereas the remaining outcomes were assessed as low-quality evidence.</div></div><div><h3>Conclusion</h3><div>The integration of Huaiqihuang granules with conventional Western medicine in the management of CVA significantly enhances clinical efficacy, reduces recurrence rates, improves immune parameters, restores pulmonary function, ameliorates inflammatory markers, and normalizes immunoglobulin levels, in comparison to the use of Western medicine alone.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102511"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shikonin enhances hypnotic effect and synergistic properties of diazepam, possibly through GABAergic interaction pathway: In vivo and in silico studies","authors":"Shipan Paul ,&nbsp;Raihan Chowdhury ,&nbsp;Md. Sakib Al Hasan ,&nbsp;Md. Shimul Bhuia ,&nbsp;Mohammed Alfaifi ,&nbsp;Salehin Sheikh ,&nbsp;Asraful Islam Rakib ,&nbsp;Faysal Mollah ,&nbsp;Shakil Ahmmed ,&nbsp;Sharmita Ghosh Situ ,&nbsp;Irfan Aamer Ansari ,&nbsp;Siddique Akber Ansari ,&nbsp;Debasree Sen Oisay ,&nbsp;Muhammad Torequl Islam","doi":"10.1016/j.eujim.2025.102508","DOIUrl":"10.1016/j.eujim.2025.102508","url":null,"abstract":"<div><h3>Introduction</h3><div>Shikonin is a natural naphthoquinone from Lithospermum erythrorhizon with diverse pharmacological activities, including neuroprotective, anti-inflammatory, and hypnotic effects.</div></div><div><h3>Methods</h3><div>The current study was focused on investigating the hypnotic effect and combination characteristics of shikonin with diazepam through in vivo and in silico studies. Swiss albino mice received shikonin (SKN-10 and SKN-20 mg/kg), diazepam (DZP-2 mg/kg) as a positive control, and a vehicle as a negative control (NC). Two combinations of SKN-10 and SKN-20 with DZP-2 were also administered before thiopental sodium-induced sleep to assess hypnosis and sedation. Different computational tools were utilized for molecular interaction and pharmacokinetics.</div></div><div><h3>Results</h3><div>In vivo study demonstrated that shikonin significantly (<em>p</em> &lt; 0.05) increased sleep duration and reduced sleep latency in animals compared to the NC group. In addition to combination therapy, SKN-10 significantly enhanced the effect of diazepam compared to DZP-2 + SKN-20, resulting in the longest sleep duration and shortest latency, indicating the strongest hypnotic effects compared to the other groups. Moreover, molecular docking indicated that the shikonin showed strong binding affinity (BA) (−8.9 kcal/mol) compared to diazepam for the GABA_A receptor.</div></div><div><h3>Conclusion</h3><div>In summary, shikonin showed significant hypnotic and synergistic effects along with diazepam. Acute toxicity studies showed shikonin caused no behavioral changes, toxicity, or mortality in mice up to 20 mg/kg, suggesting a high safety margin, with the oral LD₅₀ likely exceeding 1g/kg. Future research should explore shikonin’s long-term effects, safety, and optimal dosage, particularly in clinical settings. In vitro studies on GABA_A interactions, combination therapy with diazepam, and cognitive, behavioral, and toxicity assessments are crucial for its safe use in CNS disorders.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102508"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the development and validation of a patient centered assessment method questionnaire – patient version (PCAM-P) for use in chiropractic care generative","authors":"Cassie M. Argenbright ,&nbsp;Hayden J. Chighizola ,&nbsp;Kent J. Stuber ,&nbsp;Christopher A. Malaya","doi":"10.1016/j.eujim.2025.102530","DOIUrl":"10.1016/j.eujim.2025.102530","url":null,"abstract":"<div><h3>Introduction</h3><div>The biopsychosocial (BPS) model offers a holistic framework for patient care, yet its implementation in chiropractic settings remains limited. The Patient-Centered Assessment Method (PCAM) evaluates patient complexity within the BPS model but lacks a corresponding tool for direct patient self-report. This study aims to develop and validate a patient-facing version of the PCAM (PCAM-P) tailored specifically for chiropractic care, enabling comparison between patient and provider perspectives on BPS needs.</div></div><div><h3>Methods</h3><div>A multi-phase design will guide the development, refinement, and validation of the PCAM-P. Initial adaptation will involve expert review to ensure conceptual alignment with the original PCAM. Pilot testing and validation phases will assess face validity, construct validity, and reliability, including analyses of internal consistency and patient-provider congruency. Participants will include chiropractic patients presenting with pain and their providers, with data collected via secure, online platforms. Demographic and clinical information will be incorporated into all analyses. Primary outcomes will include the PCAM-P’s reliability and validity in assessing biopsychosocial complexity in chiropractic care. Secondary outcomes will evaluate the congruency of patient-provider assessments and the tool’s feasibility and utility in supporting BPS-informed communication and care delivery.</div></div><div><h3>Discussion</h3><div>This is the first study to develop and evaluate a mirrored BPS assessment tool specifically for chiropractic patients. The PCAM-P is designed to improve patient-provider communication, enhance care alignment, and support the integration of biopsychosocial principles into routine chiropractic practice.</div></div><div><h3>Conclusion</h3><div>The PCAM-P aims to provide a validated, patient-centered tool for biopsychosocial assessment in chiropractic care. Study findings aim to inform clinical practice guidelines and promote interdisciplinary applications of the BPS model, advancing holistic and collaborative care.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102530"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of Yiqi Jiedu decoction on diabetic peripheral neuropathy and related brain function changes: A randomized controlled trial protocol","authors":"Chaofan Sun ,&nbsp;Guoxing Ling ,&nbsp;Chunquan Sun ,&nbsp;Xingzhong Feng","doi":"10.1016/j.eujim.2025.102543","DOIUrl":"10.1016/j.eujim.2025.102543","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes, characterized by high disability and mortality rates. Pain, the primary symptom of DPN, leads to increased central nervous system responsiveness and decreased pain thresholds, resulting in conditions like hyperalgesia, anxiety, and depression—collectively referred to as \"central sensitization.\" Changes in brain structure and function are closely linked to this phenomenon but remain unclear. While functional magnetic resonance imaging (fMRI) technology can monitor brain function changes, there is limited research on the effects of interventions on these functions in patients with DPN. Yiqi Jiedu (YQJD) Decoction has been used in China to treat DPN for many years, with some studies indicating it may improve symptoms and quality of life, but there is a lack of high-quality clinical evidence, and its central mechanism of action remains unclear.</div></div><div><h3>Methods</h3><div>This ongoing randomized, double-blind, placebo-controlled trial aims to enroll about 88 patients aged 45–75 with DPN, diagnosed with qi deficiency and blood stasis syndrome. Participants will be randomly assigned in a 1:1 ratio to either receive YQJD Granules or the placebo, with follow-up assessments at weeks 4 and 8. The primary outcomes include the Toronto Clinical Scoring System (TCSS), Michigan Diabetic Neuropathy Score (MDNS), Traditional Chinese Medicine (TCM) syndrome score, nerve conduction velocity, and fMRI changes. Secondary outcomes will assess psychological characteristics in patients and changes in serum cytokines and glucose-lipid metabolism indicators.</div></div><div><h3>Discussion</h3><div>This study aims to evaluate the efficacy and safety of YQJD Decoction in the treatment of DPN using fMRI technology. It will analyze changes in brain regions before and after treatment, explore the cerebral effects of YQJD, and elucidate the relationship between central sensitization and brain effect patterns in the pathogenesis of DPN. The findings of this study will provide clinical evidence and mechanistic insights for the integration of TCM and Western medicine in the treatment of DPN. It is expected to reveal the central mechanisms involved in the intervention of neuropathic pain through Chinese herbal medicine.</div></div><div><h3>Trial registration</h3><div>Chinese clinical trial registry, ChiCTR2400084649. Registered on 22 May 2024, <span><span>https://www.chictr.org.cn/</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102543"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baihu Jia Renshen decoction for type 2 diabetes: A multi-method study combining a systematic literature review, Delphi survey, and network pharmacology","authors":"Fangyan Yang ,&nbsp;Kangle Shi ,&nbsp;Xiaoyu Liu ,&nbsp;Shiyao Wang ,&nbsp;Hongyu Meng ,&nbsp;Juan Cheng ,&nbsp;Jiayue Li ,&nbsp;Weihong Xu ,&nbsp;Yangxi Li ,&nbsp;Ruixi Tian ,&nbsp;Ling Tang ,&nbsp;Cong Lei ,&nbsp;Zhijun Wang ,&nbsp;Hongmei Duan ,&nbsp;Qinggang Meng","doi":"10.1016/j.eujim.2025.102501","DOIUrl":"10.1016/j.eujim.2025.102501","url":null,"abstract":"<div><h3>Introduction</h3><div>Baihu Jia Renshen Decoction is composed of Gypsum Fibrosum, Anemarrhenae Rhizoma, Oryza Sativa L., Glycyrrhizae Radix et Rhizoma and Ginseng Radix et Rhizoma. It is recommended by five guidelines in China for the treatment of type 2 diabetes mellitus (T2DM). However, evaluations of its efficacy involve a diverse range of outcomes. This multi-method study aims to identify clinical outcomes that traditional Chinese medicine (TCM) practitioners consider both predictive of T2DM progression and responsive to the formula, and to explore the herbal formula’s mechanisms of action on these outcomes.</div></div><div><h3>Methods</h3><div>We searched eight databases and collated clinical outcomes reported in randomized controlled trials, as well as signs and symptoms of clinical response listed in TCM clinical guidelines. A panel of eight TCM clinicians participated in three rounds of Delphi surveys to select the most important outcomes. Finally, overlapping genes between responsive outcomes-related genes and the targets of formula were obtained. Based on the enrichment analysis results, the“herb-compound-target-pathway-outcome” relationship was constructed to show how the formula affect clinical outcomes.</div></div><div><h3>Results</h3><div>Seventy-six outcomes were shortlisted from the literature, from which consensus was reached in the Delphi survey on eight. These were xerostomia, polydipsia, preference for cold drinks, red tongue, dry tongue, tongue coating dryness, large pulse and fasting blood glucose (FBG). Fifteen overlapping gene targets were identified. Based on enrichment analysis, we hypothesized that diosgenin, nicotinic acid, and anhydroicaritin from Anemarrhenae Rhizoma may act on SOD1, PPARGC1A, CHRM3, modulating AMPK signaling pathway and thereby influencing xerostomia and tongue dryness. The 29 components were found to act on PPARG, PPARGC1A, SHBG, etc, regulating insulin signaling pathway and the AMPK signaling pathway, ultimately affecting FBG.</div></div><div><h3>Conclusion</h3><div>Based on the network pharmacology studies, the potential mechanisms of action of Baihu Jia Renshen Decoction on the eight core clinical outcomes are as follows. Anemarrhenae Rhizoma may regulate dryness of the tongue and xerostomia. Anemarrhenae Rhizoma, Ginseng Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma may modulate FBG levels. Further research is needed to explore the formula’s mechanisms of action for the remaining five outcomes and T2DM.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102501"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effects of wogonin on hepatocellular carcinoma through modulation of lactate metabolism and suppression of regulatory T-cell differentiation","authors":"Fansheng Meng ,&nbsp;Yiheng Zhang ,&nbsp;Xujing Gu ,&nbsp;Tianle Ma ,&nbsp;Zhipeng Chen ,&nbsp;Huihua Fang ,&nbsp;Li Wu ,&nbsp;Huaning Xu ,&nbsp;Yan Huang","doi":"10.1016/j.eujim.2025.102545","DOIUrl":"10.1016/j.eujim.2025.102545","url":null,"abstract":"<div><h3>Introduction</h3><div>Wogonin, an active flavonoid derived from the traditional Chinese medicinal herb Scutellaria baicalensis, has been reported to regulate cellular metabolism. Increasing evidence suggests that wogonin inhibits regulatory T-cell (Treg) differentiation and modulates immune responses both <em>in vitro</em> and <em>in vivo</em>. However, the underlying molecular mechanisms remain poorly understood. Our previous findings demonstrated that lactic acid, a metabolic byproduct of glycolysis in hepatocellular carcinoma (HCC) cells, promotes the differentiation of naïve CD4⁺ <em>T</em> cells into Tregs.</div></div><div><h3>Methods</h3><div>The effects of wogonin (1.25, 5, and 20 μg/mL) on naïve CD4⁺ <em>T</em>-cell differentiation were examined in the presence of lactic acid. The proportion of Tregs was analyzed using flow cytometry. Protein and mRNA expression levels of TGF-β, p-Smad2, p-Smad3, LDHA, p-mTOR, HIF-1α, ATP5B, and FOXP3 were measured by western blotting (WB) and RT-PCR, respectively. Levels of IL-10, α-KG, and 2-HG were quantified using ELISA. To further assess <em>in vivo</em> efficacy, a mouse hepatoma transplantation model was established by subcutaneous injection of H22 cells. Seven days after inoculation, mice were treated with wogonin (12.5 or 25 mg/kg). After three weeks, mice were euthanized. Tumors underwent histological analysis by HE staining, while CD4⁺and CD8⁺ <em>T</em>-cell populations were assessed via immunohistochemistry and flow cytometry. LDHA enzyme activity, intracellular and extracellular lactate and glucose concentrations were measured by ELISA. FOXP3 and IL-10 mRNA levels were evaluated by RT-PCR.</div></div><div><h3>Results</h3><div>Supplemental lactic acid significantly increased Treg differentiation following cytokine stimulation (anti-CD3, anti-CD28, and TGF-β). Conversely, wogonin treatment significantly and dose-dependently reduced Treg differentiation and LDHA expression. Through inhibitor screening, c-Myc was identified as a critical molecular target of wogonin. Mechanistically, wogonin suppressed c-Myc activity, subsequently downregulating LDHA expression and enzyme activity, reducing abnormal accumulation of 2-hydroxyglutarate (2-HG), normalizing the 2-HG/α-KG ratio, and ultimately decreasing FOXP3 and IL-10 expression.</div></div><div><h3>Conclusions</h3><div>Wogonin suppresses Treg differentiation and exerts anti-HCC effects by inhibiting c-Myc-mediated LDHA expression and disrupting the 2-HG/ATP5B/mTOR/HIF-1α signaling pathway. Given its potential to reshape the immunosuppressive tumor microenvironment, further investigation into its combination with PD-1/PD-L1 inhibitors is warranted.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102545"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of a yoga-based mind body intervention for women with a history of hypertensive disorder in pregnancy","authors":"Caroline A Smith ,&nbsp;Kylie Barr ,&nbsp;Angela Makris ,&nbsp;Amanda Henry ,&nbsp;Hannah Dahlen ,&nbsp;Annemarie Hennessy ,&nbsp;Alison Canty ,&nbsp;Wendy Pickup","doi":"10.1016/j.eujim.2025.102499","DOIUrl":"10.1016/j.eujim.2025.102499","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertensive disorders of pregnancy affect 5 to 10% of women and are a significant cause of perinatal morbidity and mortality. This group of women have been shown to have an elevated risk of cardiovascular disease (CVD) and premature mortality. There are currently no interventions specifically targeting this at-risk group of women to reduce relevant risk factors and improve outcomes. In other populations of individuals at high CVD risk, studies suggest yoga may be effective in reducing CVD risk. This study examined the feasibility of yoga in contributing to the management of blood pressure postpartum.</div></div><div><h3>Methods</h3><div>A feasibility study was conducted. The primary objective was to examine recruitment, adherence, satisfaction, and safety of the yoga intervention. Secondary objectives included change in blood pressure, serological measures, quality of life and anxiety. Women were eligible from five to seven months postpartum. An online yoga intervention was delivered over eight weeks.</div></div><div><h3>Results</h3><div>Ten women (16% of those eligible) were recruited. All women completed the intervention. Compliance with the clinical outcome assessments ranged between 70 and 90%. There was high fidelity with intervention engagement. There were no significant changes over time in any clinical outcome, although a trend to overall improved quality of life (p=0.06) was seen. There were no adverse reactions reported.</div></div><div><h3>Conclusion</h3><div>Although uptake was low, women engaged well with postpartum yoga. Further research on yoga is needed to test effectiveness for CVD risk reduction for women with hypertension in the postpartum setting, involving an appropriately powered randomised controlled trial. The study was registered with the Australian and New Zealand Clinical Trial Registry (Registration number ACTRN: 12622000450718).</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102499"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tai Chi and resistance exercise on fatigue in patients with ulcerative colitis: A randomized clinical trial","authors":"Yu Zhou ,&nbsp;Tengteng Ding ,&nbsp;Ranran Qiao ,&nbsp;Ping Zhang ,&nbsp;Hui Li ,&nbsp;Qiong Liu","doi":"10.1016/j.eujim.2025.102519","DOIUrl":"10.1016/j.eujim.2025.102519","url":null,"abstract":"<div><h3>Introduction</h3><div>Fatigue is common and burdensome in patients with ulcerative colitis (UC), yet pharmacological treatments offer limited relief. Exercise is gaining attention as a non-pharmacological strategy, and resistance training is increasingly recommended. However, Tai Chi—a traditional Chinese exercise—has not yet been evaluated in this population. This study compared the effects of Tai Chi and resistance training on multiple outcomes in patients with UC.</div></div><div><h3>Methods</h3><div>This single-center, evaluator-blind, three-arm randomized clinical trial block-randomized 75 patients with UC to 12 weeks of Tai Chi or resistance training and a control group involving standard treatment and care with general exercise advice. Eligible participants had fatigue (Multidimensional Fatigue Inventory score ≥ 40) and were in remission or had mild-to-moderate disease activity (Modified Mayo score ≤ 10). The primary outcome was fatigue, secondary outcomes included handgrip strength (HGS), skeletal muscle mass index (SMI), sleep quality, anxiety, depression, and health-related quality of life, all strongly associated with fatigue.</div></div><div><h3>Results</h3><div>The three groups showed significant differences in total fatigue and in general, physical, and mental fatigue subdimensions. Compared with the control group, fatigue improved in both the Tai Chi group (mean difference:8.90 [95 % confidence interval [CI], -15.11 to -2.69]) and the resistance training group (mean difference:7.00 [95 % CI, -13.16 to -0.84]), with no significant differences between them. However, between the two interventions, Tai Chi showed numerically greater improvements in anxiety, depression, and emotional function, while resistance training led to greater improvements in HGS (mean difference: 7.50 [95 % CI, 2.37 to 12.63]) and SMI (mean difference: 0.54 [95 % CI, 0.01 to 1.08]). No adverse events occurred, except for one case of mild abdominal discomfort in the resistance training group, which resolved with rest.</div></div><div><h3>Conclusions</h3><div>Both Tai Chi and resistance training effectively reduced fatigue and improved related outcomes in UC patients. Tai Chi may be more beneficial for psychological symptoms, while resistance training showed greater improvements in physical strength. Given their complementary advantages and safety, both may serve as valuable non-pharmacological options in UC management. Future studies should explore their integration into long-term, multimodal treatment strategies.</div></div><div><h3>Registration</h3><div>ChiCTR2300071289.</div></div><div><h3>Funding</h3><div>None.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102519"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training needs for (UK) professional standards authority accredited register and regulated traditional, complementary and integrative medicine professions for supporting patients to make lifestyle and health behaviour changes: A rapid narrative review","authors":"Jonquil Pinto,&nbsp;Katie Read,&nbsp;Ella Tarabey,&nbsp;Felicity L. Bishop","doi":"10.1016/j.eujim.2025.102517","DOIUrl":"10.1016/j.eujim.2025.102517","url":null,"abstract":"<div><h3>Introduction</h3><div>Improving healthy lifestyles is a public health priority. Traditional, Complementary and Integrative medicine (TCIM) providers, and certain professions on the UK Professional Standards Authority (PSA) Accredited Registers (AR) may be well-placed to contribute - some TCIM professions already support patients to make behaviour changes. We aimed to map the landscape of training for PSA AR and regulated TCIM practitioners working with individuals to support lifestyle changes, including current provision, gaps and training needs.</div></div><div><h3>Methods</h3><div>We conducted a rapid narrative review of training within PSA AR and regulated TCIM professions. We searched research databases for articles exploring perceptions, experiences and responses to training (for supporting behaviour change) and searched websites of UK professional bodies for educational guidelines for pre-qualification education. We conducted systematic data searching and extraction, quality appraisal and produced a narrative synthesis of research and guidelines which identified patterns across professions.</div></div><div><h3>Results</h3><div>We identified 24 education guidelines (4 were unlocated). A total of 548 research studies were identified from database searches, and we identified 5 further studies. A total of 20 full-text articles were retrieved, 7 were excluded, leaving 13 in the review. While 22 of 24 guidelines mentioned lifestyle or health behaviour, only 4 (chiropractic, nutritional therapy, osteopathy and acupuncture) provided any detailed recommendations about how to support patients to make health behaviour changes (e.g. providing written information or recording/monitoring progress). Eight of the 13 research studies focussed on chiropractic; most studies focussed on physical activity, two on smoking cessation, and several looked at training in broad techniques including motivational interviewing. Practitioners in research studies were generally positive about training in lifestyle and health behaviour change and there was some evidence that such training enhances practitioner self-efficacy or skills.</div></div><div><h3>Conclusions</h3><div>Most evidence of engagement with supporting lifestyle/behaviour change is within four professions: chiropractic, osteopathy, nutritional therapy and acupuncture. To build on existing knowledge and practice, future training for chiropractors, osteopaths, nutritional therapists and acupuncturists could target the capabilities (e.g. knowledge, skills, decision-making), opportunities (e.g. resources) and motivations (e.g. social/professional role) of practitioners. Future research should also evaluate the impact of practitioner training on patients’ lifestyle and health behaviours.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102517"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is traditional Chinese medicine syndrome differentiation important in primary insomnia? An exploratory review with matching recombination indirect comparisons and network meta-analysis","authors":"Guo-Dong Li ,&nbsp;Xin-Yu Hu ,&nbsp;Yi Yuan ,&nbsp;Xi-Jing Meng ,&nbsp;Le-Yan Hu ,&nbsp;Yu-Ting Huang ,&nbsp;Hui-Juan Cao","doi":"10.1016/j.eujim.2025.102515","DOIUrl":"10.1016/j.eujim.2025.102515","url":null,"abstract":"<div><h3>Introduction</h3><div>Syndrome differentiation is the primary method of Traditional Chinese Medicine (TCM) diagnosis and treatment of diseases and has become the key to the clinical development of acupuncture. However, there is a lack of supporting clinical evidence to determine the impact of syndrome differentiation on the efficacy of acupuncture treatment. Therefore, we aimed to evaluate the importance of point selection based on syndrome differentiation by re-analyzing the trials' results in treating primary insomnia with acupuncture.</div></div><div><h3>Methods</h3><div>We systematically searched 9 databases for eligible trials. Two authors extracted data independently from citations, interventions, and outcomes. Since the \"treatment acupuncture\" and \"control acupuncture\" data compared in this study were from different trials, we matched the data in a 1:1 ratio and minimized heterogeneity between the paired groups. Matching factors included age, sex ratio, and the baseline Pittsburgh Sleep Quality Index (PSQI) score. Meta-analyses were performed using Revman 5.4 software. STATA 15.0 was used for the network meta-analysis. Effect estimation presented continuous data with a standard mean difference (SMD) with a 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>We included a total of 172 trials. After matching, 19 recombinational pairs of studies were established. Meta-analysis of the 19 pairs showed that PSQI scores in the syndrome differentiation group were lower than the non-syndrome differentiation group (SMD: -0.87, 95 %CI -1.46 to -0.28, <em>P</em> = 0.004). Network meta-analysis of all included trials showed no statistical difference in acupoints selection between syndrome and non-syndrome differentiation (SMD: -0.40, 95 % CI -2.63 to 1.84). However, acupoint selection based on syndrome differentiation (43.9 %) ranks higher than acupoint selection based on non-syndrome differentiation (38.0 %) according to SUCRA curves.</div></div><div><h3>Conclusions</h3><div>Current evidence does not conclusively support the superiority of syndrome differentiation-based acupuncture over non-syndrome differentiation for primary insomnia. While statistically significant large effect size was observed in matched studies, the clinical relevance of this difference remains uncertain due to methodological limitations, heterogeneity, and inconsistent findings across analytical approaches. Future trials with direct comparisons and standardized outcome measures are needed to clarify the clinical utility of syndrome differentiation in acupuncture therapy.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102515"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}