DOTTs--结核病治疗植物数据库：合理利用传统医药进行治疗

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

European Journal of Integrative Medicine Pub Date : 2024-10-01 DOI:10.1016/j.eujim.2024.102409

Hazarika Risha , Gangar Tarun , Patra Sanjukta

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引用次数: 0

摘要

导言结核分枝杆菌是一种导致结核病（TB）的高度耐药性超级细菌，是造成全球死亡的主要原因之一。人们对改良药物方案和疗法进行了广泛研究，但仍未证明它们能完全有效地消灭病原体或其耐药形式。因此，我们需要其他新颖的治疗方法来解决这一问题。传统医学在通过成文法（阿育吠陀、悉达、尤那尼）和非成文法（民间医学）治疗结核病方面发挥着重要作用。近年来，利用药用植物治疗结核病已引起广泛关注。发现未被充分开发的治疗结核病的植物有助于制定未来的治疗策略。本研究旨在将民族植物学文献汇集到一个统一的平台上，以便深入了解未记载的部落/民间结核病治疗方法。通过使用 Bootstrap 层叠样式表（CSS）主题的 PHP-HTML 平台开发的用户友好型网络界面向用户展示数据，数据库由 MySQL 数据库管理系统（DBMS）管理。数据库中提供了总共 100 种植物的当地名称、分类学分类（目和科）、部落、植物部位、配方以及抗结核属性。结论 DOTTs 数据库提供了 100 种印度药用植物的民族植物学和民族药理学数据。该数据库将帮助研究人员获取有关这些植物的信息，从而有利于进一步评估和发现结核病药物研发的潜在线索。通过适当的调查和研究，结核病有望不再成为严重的公共卫生风险。

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DOTTs-Database of Therapeutic Plants against Tuberculosis: Rationalizing traditional medicine for therapeutic applications

Introduction

Mycobacterium tuberculosis, a highly resistant superbug causing tuberculosis disease (TB), contributes to one of the leading causes of death worldwide. Improved drug regimens and therapeutics have been extensively studied, but still none are proven to be fully effective in eliminating the pathogen or its drug-resistant forms. Therefore, alternative and novel therapeutic approaches to address this problem are needed. Traditional medicine can be vital in managing TB via codified (Ayurveda, Siddha, Unani) and uncodified systems (folk medicine). In recent years, the utilization of medicinal plants for TB therapy has garnered considerable attention. Identifying underexplored plants utilized as a remedy for TB can aid in developing future treatment strategies. The current study aims to assemble the ethnobotanical literature that provides insight into the undocumented tribal/folk medicinal practices against tuberculosis in one unified platform.

Methods

The medicinal plants with therapeutic properties against tuberculosis were identified manually by screening published literature. The data is represented to the users using a user-friendly web interface developed via the PHP-HTML platform using Bootstrap Cascading Style Sheet (CSS) theme, and the database is managed by MySQL Database Management System (DBMS).

Results

Database of Therapeutic Plants against Tuberculosis (DOTTs) describes the medicinal plants used traditionally in different forms against tuberculosis by various indigenous tribes and communities in India. A total of 100 plants with their local names, taxonomical classification (order and family), tribe, plant part, and formulations, as well as the anti-tubercular attributes, are provided in the database. Additional information about the plants can be retrieved from the external links provided.

Conclusion

The DOTTs database provides the ethnobotanical and ethnopharmacological data of 100 Indian medicinal plants. This database will help the researchers acquire information about the plants that could be beneficial for further evaluation and discovery of potential leads in TB drug discovery. With proper investigation and advancement, it is anticipated that TB could no longer be a serious public health risk.

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来源期刊

European Journal of Integrative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

4.70

自引率

4.00%

发文量

102

审稿时长

33 days

期刊介绍： The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education. EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians. The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.