The dose-effect relationship of acupuncture in the treatment of functional gastrointestinal disorders: A meta-regression of randomized controlled trials
IF 1.9 4区 医学Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Siyao Gong, Xin Yu, Jiao Yang, Dan Huang, Shuguang Yu, Sha Yang
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引用次数: 0
Abstract
Introduction
The efficacy of acupuncture in treating functional gastrointestinal disorders (FGIDs) has been widely acknowledged. However, the dose-response relationship between acupuncture frequency and FGIDs remains uncertain. This review aimed to explore the relationship between the number of acupuncture sessions and the efficacy of acupuncture for FGIDs.
Methods
Seven major databases were searched from their inception to April 25, 2023. Literature screening, risk of bias assessment, and data extraction were performed by two reviewers independently. The quality of included randomized controlled trials (RCTs) was assessed using the Cochrane bias risk tool and Jadad score. The dose-effect relationship between acupuncture sessions and the clinical response rate in patients with FGIDs was investigated by using the cubic spline limited nonlinear meta-regression method in statal5.1. Before the review, we conducted the PROSPERO registration (CRD42022344699).
Results
Our analysis included 100 studies on acupuncture treatment of FGIDs, encompassing 8,589 participants. The meta-analysis of the dose-response relationship indicated that acupuncture could improve clinical symptoms and clinical response in patients with FGIDs to some extent. The clinical response rate increased with the number of acupuncture sessions in the range of ten to twenty sessions, with the odds ratio (OR) value rising from 1.05 (95 % CI: 0.89, 1.21) to 1.38 (95 % CI: 1.22,1.53). The peak of clinical response rate was observed at 24 acupuncture sessions (OR = 1.40; 95 % CI: 1.25, 1.55), representing a 40 % increase in OR. Compared with 24 sessions, the clinical response rate decreased after 56 sessions (OR = 1.22; 95 % CI: 0.64, 1.81).
Conclusion
There is a dose-response relationship between the number of acupuncture sessions and the clinical response in individuals with FGIDs. Twenty-four acupuncture treatments correlate with the optimal clinical response.
期刊介绍:
The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education.
EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians.
The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.