European Journal of Clinical Nutrition最新文献

{"title":"Association between the geospatial school food environment and nutritional outcomes among school children: a systematic review.","authors":"Hema Matela, Pooja Panchal, Aditya Singh, SukhDev Mishra, Kavitha Menon","doi":"10.1038/s41430-026-01826-y","DOIUrl":"https://doi.org/10.1038/s41430-026-01826-y","url":null,"abstract":"<p><p>The food environment around the school influences children's food choices and dietary practices. The present review studied the status of the outside school food environment and its impact on children's nutritional outcomes. The present study conducted a systematic literature search across four electronic scientific databases (Science Direct, PubMed, SCOPUS, and Web of Science) from January 2010 and February 2024. A comprehensive search yielded 4260 articles, and 61 eligible studies were included. The evidence suggested that the proximity to the food outlets significantly influences the nutritional status of the schoolchildren, regardless of the number and the type of outlets offering unhealthy foods around the schools. Nutritional outcomes are more influenced when food service establishments are located within 800 m of schools. Findings from developed countries indicate that closer proximity to food outlets (<800 m) is associated with poor dietary practices and higher BMI/obesity. Limited insights are observed from developing countries. The study highlights recommend for enhanced methodological standards to increase the comparability of research and to formulate evidence-based zoning regulations for restricting the sale of unhealthy foods around the school.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision diagnosis guides ketogenic diet therapy in inherited metabolic epilepsies: Concurrent non-ketotic hyperglycinemia and biotinidase deficiency.","authors":"Amany Elbarky, Doaa El Amrousy, Sally Mahmoud, Aya Lotfy, Mohamed Aboeisa, Khalid Elsayed Elballat, Salma Khamis, Reem Naser, Assma Maher, Heba Dawoud","doi":"10.1038/s41430-026-01821-3","DOIUrl":"https://doi.org/10.1038/s41430-026-01821-3","url":null,"abstract":"<p><p>Non-ketotic hyperglycinemia (NKH) and biotinidase deficiency are rare inborn errors of metabolism that individually predispose to severe, drug-resistant epilepsy. Their concurrent occurrence in a single patient represents an exceptionally uncommon diagnostic and therapeutic challenge. The ketogenic diet (KD) has emerged as an adjuvant effective intervention in metabolic epilepsies, yet its role in dual metabolic disorders of this nature has not been previously described. We report female infant with autosomal recessive glycine encephalopathy (NKH) and biotinidase deficiency confirmed by whole exome sequencing and enzyme assay, who presented with neonatal-onset focal seizures and progressive encephalopathy refractory to five anti-seizure medications (ASMs). Initiation of classic 3:1 KD occurred during a PICU admission supervised by a multidisciplinary team (MDT) at 18 months of age. Within two weeks, significant clinical improvement was observed. Over the subsequent year, seizures were controlled, three ASMs were successfully withdrawn, encephalopathy episodes were eliminated, nasogastric tube feeding was discontinued, and the patient achieved meaningful neurodevelopmental milestones. This case highlights the potential of the KD as a unified therapeutic approach to improve clinical outcomes in patients with co-existing NKH and biotinidase deficiency. Early implementation of KD under the guidance of MDT may interrupt the neurotoxic cascade of glycine accumulation and biotin-dependent metabolic dysfunction, enhancing seizure control, development and quality of life.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of day-to-day variation in dietary intake on dietary patterns identification through factor analysis.","authors":"Giovanna da Conceição Nepomuceno, Diana Barbosa Cunha, Eliseu Verly Junior","doi":"10.1038/s41430-026-01827-x","DOIUrl":"https://doi.org/10.1038/s41430-026-01827-x","url":null,"abstract":"<p><strong>Background/objectives: </strong>Short-term dietary assessments, such as 24-h recalls, are affected by day-to-day variation, influencing the stability and identification of dietary patterns through factor analysis. We evaluated the effect of within-person random error on replicating these patterns.</p><p><strong>Methods: </strong>Twenty non-consecutive 24-h recalls were completed by 302 adults over about three months. Individual usual intakes were defined as the average of 20 days. Factor analyses identified: (i) usual dietary patterns (20dDP), based on usual individual intakes; and (ii) n-day (n = 2, 3, or 4) dietary patterns (ndDP), based on all possible recall combinations. Factor mirroring and interchangeability ensured alignment for comparison between 20dDP and ndDP factor loadings distributions.</p><p><strong>Results: </strong>Three usual dietary patterns were identified: Prudent, Traditional, and Western, explaining 25% of the variance. Mean loading factors from 190 two-day combinations were weaker than the usual ones, with substantial attenuation in the third factor. Foods in the usual first and second factors were consistently identified in most 2-day combinations. In contrast, foods of the usual third pattern were identified largely by chance, depending on the sampled 2-day combination, and more foods not belonging to this factor were incorrectly assigned. This indicates that while two-day data capture major patterns, subsequent, less explanatory factors are highly susceptible to random error. Results were similar for 3 and 4-day combinations.</p><p><strong>Conclusions: </strong>Usual dietary patterns can be identified using at least 2 non-consecutive collection days; however, the first factor is most stable, while subsequent factors show greater susceptibility to day-to-day variation, potentially compromising replication of usual dietary patterns.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of rest interval time during resistance exercise on postprandial triglyceride concentrations in resistance-trained young men.","authors":"Eiji Pereira, Yoshiki Yamada, Miki Sakazaki, Stephen F Burns, Masashi Miyashita","doi":"10.1038/s41430-026-01819-x","DOIUrl":"https://doi.org/10.1038/s41430-026-01819-x","url":null,"abstract":"<p><strong>Objective: </strong>Elevated postprandial triglyceride (TG) is a risk factor for cardiovascular disease. This study investigated the acute effect of whole-body resistance exercise with different rest interval durations, but identical volume and intensity, on postprandial TG concentrations.</p><p><strong>Methods: </strong>Fifteen healthy men (age: 23.1 ± 3.4 years; BMI: 24 ± 3 kg/m²) completed two exercise trials and one control (rest) trial in a randomised crossover design, each separated by a 7-day washout. On day 1, participants performed resistance exercises with either 30-s (short rest) or 180-s (long rest) intervals between sets or rested throughout the day. Both resistance exercise trials employed identical exercises, sets, repetitions and external load. On day 2, 17.25 h later, participants consumed a standardised test meal (0.56 g fat per kg of body mass), followed by blood sampling at baseline and 0.5, 1, 1.5, 2, 4 and 6 h postprandially.</p><p><strong>Results: </strong>Participants lifted a total volume of 6433 ± 1554 kg on each exercise trial. However, no significant differences were observed in fasting (P = 0.061) or postprandial (main effects of trial, P = 0.147; trial-by-time interaction P = 0.058) TG concentrations among trials.</p><p><strong>Conclusion: </strong>Whole-body resistance exercise with different rest intervals did not reduce postprandial TG concentration in resistance-trained young men.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148967181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition, geography and ethnicity: understanding the associations with health.","authors":"Jonathan Ck Wells","doi":"10.1038/s41430-026-01824-0","DOIUrl":"https://doi.org/10.1038/s41430-026-01824-0","url":null,"abstract":"<p><p>Human body composition varies substantially across populations, for a range of different reasons that remain poorly understood. Similar to body size and limb proportions, both fat-free and fat mass are geographically patterned, which may relate both to ancestry but also to persisting ecological stresses, whose effects may be transmitted through the life-course and across generations. The role of genetics in such variability remains uncertain, moreover relevant ecological stresses include not only physical (e.g. temperature) and biological (e.g. diet, subsistence, pathogen burden) components, but also societal factors including colonisation, conflict, migration and economic inequality. Body composition variability has major implications for health inequalities, and improving our understanding of the different underlying mechanisms may help us understand how to design public health interventions, and optimise the prevention and management of disease. However, the terminology used to address population variability in body composition needs to be reconsidered. Terms such as race/ethnicity, ancestry and geography are widely used to frame investigations and interpret findings, but the variable most often collected in studies is ethnicity, selected by research participants on the basis of their identity. Race has no biological validity, but may be a marker of exposure to racism and discrimination. Improved understanding of the multiple components of biology that relate to ethnicity may help understand the sources of population variability in body composition, and hence improve efforts to reduce health inequalities.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ResB supplementation on gut microbiome composition in elderly pneumonia: a randomized pilot trial.","authors":"Shree Rath, Rishikesh Dash, Manisha Pattanayak, Kavya Varshni, Puja Sohal, Priyanka Mishra, O M Padarabinda Dash, Sourin Bhuniya, Jayant Kumar Mitra, Balamurugan Ramadass","doi":"10.1038/s41430-026-01822-2","DOIUrl":"https://doi.org/10.1038/s41430-026-01822-2","url":null,"abstract":"<p><strong>Rationale: </strong>Pneumonia remains a leading cause of morbidity and mortality in older adults, often exacerbated by immune dysregulation and prolonged hospitalization. The gut-lung axis is increasingly recognized as a modulator of respiratory immunity, yet the therapeutic potential of targeted probiotic interventions in elderly pneumonia patients remains underexplored.</p><p><strong>Objectives: </strong>To characterize gut microbial compositional changes, temporal shifts, and microbial interaction network dynamics associated with ResB® Lung Support probiotic supplementation in elderly patients hospitalized with pneumonia in this exploratory, hypothesis-generating pilot trial.</p><p><strong>Methods: </strong>In a randomized, double-blind, placebo-controlled trial, patients aged ≥60 years admitted with Pneumonia received either resB® probiotic capsules or placebo for 14 days alongside standard care. Stool samples were collected at baseline, day 15, and day 30 (or discharge). Microbiome profiling was performed using 16S rRNA gene sequencing. Statistical analyses included linear mixed-effects Modeling, Wilcoxon rank-sum tests, and trajectory and network assessments.</p><p><strong>Results: </strong>Sixteen patients completed the study. The probiotic group exhibited increased abundance of several beneficial taxa, including Bifidobacterium longum (p = 0.08, FDR = 0.16) and Blautia_A_141781 (p = 0.05, FDR = 0.1), along with positive temporal shifts in Prevotella copri and CAG_83. Pathogenic genera such as Corynebacterium (p = 0.06, FDR = 0.3) and Streptococcus (p = 0.07, FDR = 0.3) declined in the treatment arm. Log-fold change analysis showed significant increases in CAG_83 (p = 0.02, FDR = 0.09) and P. copri (p = 0.027, FDR = 0.09), with an upward trend for B. longum (p = 0.09, FDR = 0.18). Microbiome trajectory analysis indicated temporal shifts in gut microbial composition in the treatment group, and network analysis demonstrated enhanced connectivity among commensal taxa with reduced pathogenic interactions.</p><p><strong>Conclusions: </strong>Probiotic supplementation with resB® Lung Support was associated with changes in gut microbiome composition in elderly pneumonia patients, including shifts in several commensal and potentially pathogenic taxa. Given the exploratory nature of this pilot trial, these findings should be interpreted cautiously. The results suggest that microbiome-targeted nutritional interventions may influence gut microbial dynamics during acute respiratory illness and warrant further investigation in larger, multicenter studies.</p><p><strong>Trial registration number: </strong>CTRI/2022/04/041687 (URL: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=NjY5MjI) .</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary macronutrient intake and the gut microbiome in adults undergoing bariatric surgery.","authors":"Sarah J Lande, Lydia M Stephney, Lucia A Gonzalez Ramirez, Paula-Dene C Nesbeth, Terryl J Hartman, Dean P Jones, Damaskini Valvi, Elizabeth M Hechenbleikner, Edward Lin, Rob S McConnell, Vaia Lida Chatzi, Jessica A Alvarez, Thomas R Ziegler","doi":"10.1038/s41430-026-01800-8","DOIUrl":"10.1038/s41430-026-01800-8","url":null,"abstract":"<p><p>Information linking diet with the gut microbiome in bariatric surgery is limited. This pilot study examined correlations between macronutrient intake and gut microbiome indexes in adults undergoing bariatric surgery. Participants were 29 adults (93% female) undergoing bariatric surgery. Food records were used to estimate daily macronutrient intake. Shotgun sequencing was used in pre- and post-operative stool samples to identify changes in microbial composition. Diversity indices and differential abundance were calculated, and correlations between dietary intake and outcomes were assessed using linear regression and machine learning models. Phyla and genera were statistically correlated with macronutrient intakes, in particular, intake of soluble fiber, insoluble fiber, and dietary glycemic index. Changes in nutrient-related functional gene pathways were linked to change in HEI-2015 scores and in soluble and insoluble fiber intake following bariatric surgery. In this hypothesis-generating study, intakes of specific macronutrients were correlated with several microbial phyla, genera, and nutrient-related functional gene pathways.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of ready-to-use-therapeutic-food (RUTF) on micronutrient levels in undernourished children with cancer: a randomized open-labelled controlled study.","authors":"Maya Prasad, Shyam Srinivasan, Alka Jadhav, Girish Chinnaswamy, Ronald D Barr, Elena J Ladas","doi":"10.1038/s41430-026-01823-1","DOIUrl":"https://doi.org/10.1038/s41430-026-01823-1","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence suggests that micronutrient deficiencies are predictive of poorer outcomes in children with cancer. We assessed the prevalence and clinical impact of circulating micronutrient concentrations, as well as the change in micronutrient status after RUTF supplementation, in undernourished children with cancer.</p><p><strong>Methods: </strong>Undernourished children with cancer were randomized 1:1 to receive either standard nutritional therapy(SNT) or SNT + RUTF for 6 weeks. The primary outcome was weight gain, and secondary outcomes included changes in micronutrient status from study entry to 6 weeks, including serum copper, phosphorus, zinc, iron, B12 and 25-OH vitamin D3. Predefined laboratory reference cut-offs for low circulating micronutrient concentrations were applied. Clinical outcomes assessed were significant infection, grade 3-4 mucositis and treatment delay >1 week.</p><p><strong>Results: </strong>Between July-2015 and March-2018, 260 subjects were enrolled; 191 (76.7%) had low circulating concentrations of at least one micronutrient and 37 (14.9%) low circulating concentrations of 3 or more micronutrients. Low circulating concentrations were noted with vitamin D3-111 (42.7%), serum zinc in 97 (37.3%), phosphorus-62 (23.8%) and iron-45 (18%). Fewer children who received RUTF-34 (27.6%) had low zinc concentrations compared to SNT-45 (35.7%, p = 0.045) and 35 (25.5%) had improvement in vitamin B12 concentrations compared to SNT-23 (18.3%, p = 0.045). Irrespective of treatment arm, low circulating zinc and copper at study entry were associated with treatment delay (OR 1.8; 95% CI 1.1-3.2 and OR 4.7; 95% CI 0.4-53.2, respectively). Low circulating vitamin B12 was associated with toxic death (OR 9.7; 95% CI 2.4-38.8).</p><p><strong>Conclusions: </strong>There is a high prevalence of low circulating micronutrient concentrations, specifically vitamin D3, zinc, phosphorus and iron in children with cancer, often associated with adverse clinical outcomes. Supplementation with RUTF showed an inconsistent improvement in micronutrient levels. The clinical impact of micronutrient deficiencies in children with cancer should be the focus of future interventional trials. There is a need for evidence-based micronutrient supplementation in children with cancer.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal tolerance and compliance during a 2-week intervention of reformulated tube feeds with a plant-dominant protein blend in community-based adult patients on long-term nutritional support.","authors":"Claudia A van den Berg, Elise J M van Eijnatten, Peter Top, Agata Zoubek-Wojcik, Piotr Wojcik, Jan Csomor, Michaël Sels, Sonia Amodio, Margriet Veldhorst, Zandrie Hofman","doi":"10.1038/s41430-026-01814-2","DOIUrl":"https://doi.org/10.1038/s41430-026-01814-2","url":null,"abstract":"<p><strong>Background and aims: </strong>Gastrointestinal (GI) tolerance is essential for effective tube feeding (TF) in patients with, or at risk of, disease-related malnutrition. This study evaluated GI tolerance, energy intake, compliance, body weight, and safety of four reformulated TFs with a higher proportion of plant-based proteins and improved vitamin composition versus commercially available TFs.</p><p><strong>Methods: </strong>In this single-arm, open-label, multicountry study, 100 community-based adults on long-term TF continued their usual TF for one week (baseline week [BW]), followed by a 2-week intervention with one of four reformulated TFs (1.0 or 1.5 kcal/mL; with/without fiber) matched for energy density and fiber content. Outcomes included GI tolerance, energy intake, compliance, body weight, and safety. Results from the second intervention week (IW2) were compared with BW.</p><p><strong>Results: </strong>98% of subjects reported no or mild symptoms. The incidence of diarrhoea (BW: 2.0%, IW2: 1.0%) and constipation (BW: 0.0%, IW2: 1.0%) was very low. Compliance was ≥95% in 98% of subjects in BW and IW2. Energy intake (BW: 1396 ± 357 vs. IW2: 1400 ± 355 kcal/day, p = 0.954) and body weight (BW: 65.9 ± 12.0 vs. IW2: 66.1 ± 11.6 kg, p = 0.812) remained stable. No serious adverse events (AE) were reported. AEs were reported in 7 subjects (7%) during the intervention period, which were either unlikely related to the study product or as expected.</p><p><strong>Conclusions: </strong>Community-based adults on long-term TF, who used a reformulated TF with a plant-dominant protein blend for two weeks, tolerated the TF very well, maintained their body weight, and had excellent TF compliance. No safety concerns associated with these TFs were identified. These findings support their use in clinical practice.</p><p><strong>Registration number of clinical trial: </strong>NCT05902806.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.","authors":"Lijun Shen, Kai Wang, Renjie Li, Yafang Li, Yunchong Guo, Fangping Li, Jinqiu Yuan, Zhen Yang, Bin Xia, Xiahong Lin","doi":"10.1038/s41430-026-01805-3","DOIUrl":"https://doi.org/10.1038/s41430-026-01805-3","url":null,"abstract":"<p><strong>Background/objectives: </strong>The relationship between one-carbon metabolism (OCM) nutrients (methionine, folate, vitamin B2, vitamin B6, and vitamin B12) and metabolic dysfunction-associated steatotic liver disease (MASLD) remains uncertain. This study aimed to examine the association of dietary intake OCM nutrients intake with liver-related events (LRE) and mortality among individuals with MASLD.</p><p><strong>Methods: </strong>This prospective cohort study analyzed data from 46,800 participants in the UK Biobank. MASLD was defined using a validated Fatty Liver Index (FLI) ≥ 60. Dietary intake was assessed using a web-based 24-hour dietary recall tool. Participants with a history of cancer or LRE at baseline were excluded. Multivariable Cox proportional hazard models and restricted cubic splines (RCS) were employed to estimate hazard ratios (HRs) and evaluate dose-response relationships.</p><p><strong>Results: </strong>During a median follow-up of 13.3 years, 291 incident LRE cases and 3547 deaths occurred. Higher dietary intakes of several OCM nutrients were associated with lower risks of LRE and mortality, with the strongest evidence observed for vitamin B6. The HRs and 95% CIs of LRE comparing the highest with lowest intake categories were 0.74 (0.53, 1.04) for methionine, 0.66 (0.48, 0.92) for vitamin B6, 0.78 (0.56, 1.08) for vitamin B2, 0.71 (0.51, 0.99) for vitamin B12, and 0.72 (0.52, 1.00) for folate. Similar inverse associations were observed for mortality. RCS analyses indicated an approximately linear dose-response relationship with LRE incidence, whereas the associations with mortality appeared non-linear.</p><p><strong>Conclusions: </strong>Higher dietary intake of OCM nutrients is associated with lower risks of LRE and mortality in populations with MASLD.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}