European Journal of Clinical Nutrition最新文献

{"title":"Exercise and nutrition interventions for sarcopenia in cirrhosis: a systematic review and network meta-analysis of randomized controlled trials.","authors":"Sirinda Kittiprachakul, Soe Thiha Maung, Napalai Poorirerngpoom, Asadapong Srinawakul, Merint Numpaisarn, Thodsawit Tiyarattanachai, Nicha Somlaw, Onanong Kulaputana, Prooksa Ananchuensook, Jeerath Phannajit, Sarissa Rangkla, Roongruedee Chaiteerakij","doi":"10.1038/s41430-025-01642-w","DOIUrl":"https://doi.org/10.1038/s41430-025-01642-w","url":null,"abstract":"<p><p>Sarcopenia is highly prevalent and associated with poor outcomes in cirrhotic patients. We aimed to evaluate the efficacy of exercise, protein supplementation, and branched-chain amino acid (BCAA) supplementation in treating cirrhotic sarcopenia. PubMed, Embase, Scopus and the Cochrane Library were searched for randomized controlled trials of exercise, protein supplementation, and/or BCAA supplementation on improving at least one of the sarcopenia features: muscle mass, muscle strength and physical performance. Differences in post- and pre-intervention changes between intervention and control arms were calculated as a standardized mean difference (SMD), with 95% confidence interval (CI). A network meta-analysis (NMA), component NMA, pairwise meta-analysis (PW-MA) of 23 trials comprising 1525 participants were performed. By NMA, combined exercise with protein and BCAA supplementations had the greatest effect on increasing muscle mass (SMD 2.12; 95%CI: 0.59-3.65). Exercise alone or with BCAA/protein supplementation also significantly increased muscle mass, but protein or BCAA supplementation alone did not increase muscle mass. By PW-MA, exercise significantly improved physical performance versus control (SMD 1.43; 95%CI: 0.63-2.17; p < 0.01; I² = 59%) and exercise plus protein supplementation was superior to protein alone (SMD 0.66; 95%CI: 0.26-1.06; p = 0.001; I² = 0%). In the systematic review of effects of BCAA supplementation on muscle strength, its impact was inconclusive. Exercise is the mainstay of sarcopenia treatment in cirrhosis and is most effective at improving muscle mass when combined with protein and BCAA supplementation. Nutritional supplementation alone does not enhance muscle mass. Further well-designed studies are needed to identify the most effective type of exercise.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide-induced Wernicke encephalopathy: a comprehensive analysis.","authors":"Cécile Gras, Victoria De Wit, Nacima Oussedik, Sylvie Daclin, Venceslas Bourdin, Delphine Callot, Ghiles Chegrani, Claire Rives-Lange, Laurent Chouchana","doi":"10.1038/s41430-025-01653-7","DOIUrl":"https://doi.org/10.1038/s41430-025-01653-7","url":null,"abstract":"<p><p>Although GLP-1 receptors analogues (RAs) benefits-risks profile has been largely documented in diabetes, higher dosages recently approved in obesity still require further assessment. We describe here the case of a 49-year-old female patient treated with semaglutide for obesity, who presented with Wernicke encephalopathy in a context of iterative vomiting and reduced food intake. Eighteen other cases of Wernicke encephalopathy were reported in literature and in the WHO global safety database (VigiBase). A context of nausea/vomiting or reduced food intake is described in 68% of cases, with weight loss ranging from -3.5 to -13.3 kg/month over 3 to 6 months. Disproportionality analysis in VigiBase showed that Wernicke encephalopathy was disproportionately reported with semaglutide, tirzepatide and the whole GLP-1RAs group. Altogether, this comprehensive analysis supports a safety signal regarding the risk of Wernicke encephalopathy with GLP-1RAs, which requires a prompt assessment, accounting for the growing use of these drugs.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal folic acid supplementation in different pregnancy and infant neurobehavioral development at 6 and 18 months.","authors":"Maoyuan Yang, Zengyao Wang, Ke Zhou, Siyi Ren, Yu Cao, Xinglin Jin, Mei Li, Xia Zhou, Guanghui Sui, Yating Ren, Yuyan Zhang, Mengru Chen, Yuyan Gao, Jie Sheng, Sufang Wang","doi":"10.1038/s41430-025-01657-3","DOIUrl":"https://doi.org/10.1038/s41430-025-01657-3","url":null,"abstract":"<p><strong>Background: </strong>It has been proven that periconceptional folic acid (FA) supplementation could prevent neural tube defects. However, FA supplementation during different stages of pregnancy and its association with the neurobehavioral development of offspring remains unclear, particularly the effects of continued FA supplementation during the second and third trimesters. This study aimed to investigate the relationship between maternal FA supplementation at various stages of pregnancy and infant neurobehavioral development.</p><p><strong>Methods: </strong>In a prospective birth cohort study involving 3246 parent-child pairs, 2905 infants completed neurobehavioral development assessments at 6 months and 3005 infants at 18 months. Information regarding micronutrient supplementation at various stages of pregnancy was recorded. Multivariable logistic regression was used to evaluate the association between FA supplementation and infant neurobehavioral developmental delays. In addition, propensity score analysis was performed to correct the potential imbalances in the distribution of related factors between the groups.</p><p><strong>Results: </strong>During the periconceptional period, maternal standardized FA supplementation (taking 0.4 mg FA daily before and in early pregnancy, as officially recommended) was associated with a reduced risk of possible development delays in 18-month-old infants in the communication domain (RR = 0.48, 95% CI: 0.26-0.86; P = 0.015). After the 12th gestational week, maternal continuous FA supplementation in the second and third trimesters was significantly associated with a decreased risk of possible neurobehavioral development delay in 6-month-old infants in fine motor domain (RR = 0.31, 95% CI: 0.12-0.82; P = 0.019) and the problem-solving domain (RR = 0.20, 95% CI: 0.05-0.79; P = 0.022). These associations remained significant after adjusting for confounders and propensity scores.</p><p><strong>Conclusions: </strong>FA supplementation at different stages of pregnancy may enhance neurobehavioral development in offspring. To confirm these findings, additional investigations or trials with larger sample sizes and consistent tracking of folate status throughout pregnancy are recommended.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of orally administered cetylated fatty acids on symptoms and functional capacity in patients with knee osteoarthritis: results of a randomized, double-blind, placebo-controlled study.","authors":"Manana Zodeleva, Nino Pochkhua, Maria Sole Rossato, Eka Arziani","doi":"10.1038/s41430-025-01656-4","DOIUrl":"https://doi.org/10.1038/s41430-025-01656-4","url":null,"abstract":"<p><strong>Background/objectives: </strong>The development and implementation of new treatments for knee osteoarthritis in routine practice remains an unmet need. The aim of this study was to assess the efficacy and safety of a Cetylated Fatty Acids (CFA)-based dietary supplement in patients with knee osteoarthritis (OA), a prevalent and difficult-to-treat condition.</p><p><strong>Subjects/methods: </strong>60 patients (mean age: 66.0 ± 7.7 years, 85% female) with grade 3-4 knee osteoarthritis and a pain intensity of > 4 cm on the visual analog scale (VAS) were enrolled and randomized in a 1:1 ratio to receive either 1.5 g of oral CFA or a placebo for 60 days. The primary outcome was the change in pain intensity (VAS), secondary outcomes included changes in range of motion (ROM), in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the safety profile of the food supplement.</p><p><strong>Results: </strong>After 60 days of CFA assumption, the mean reduction in pain intensity (VAS) was -1.7 cm (95% CI [-2.0, -1.4]), showing a statistically significant difference compared to placebo (-0.6 cm, 95% CI [-1.0, -0.2]; p < 0.005). The mean decrease in the WOMAC total score was also greater in the CFA group (-19.5 vs. -15.8), although the placebo-corrected effect was not statistically significant (-3.7, 95% CI [-8.3, 0.8]; p = 0.108). Observed improvements in flexion (3.8° [95% CI: 2.6, 5.0]) and external rotation (2.9° [95% CI: 2.1, 3.8]) were both statistically significant in favor of CFA (p ≤ 0.001) compared to placebo. Differences in extension and internal rotation were negligible. The safety profile of the investigational product resulted favorable, considering that only 4 out of 30 patients reported mild adverse events, and none withdrawn from the study due to adverse events.</p><p><strong>Conclusion: </strong>In patients with knee osteoarthritis, incorporating a CFA oral supplement into the treatment regimen provides superior efficacy in pain relief and range of motion improvement compared to placebo, while maintaining a favorable safety profile.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term low-carbohydrate diet decreases body weight and fat mass but not muscle strength in children and young people with type 1 diabetes.","authors":"V Neuman, K Maratova, L Plachy, L Drnkova, S Pruhova, S Kolouskova, B Obermannova, S A Amaratunga, M Kulich, J Havlik, O Cinek, Z Sumnik","doi":"10.1038/s41430-025-01658-2","DOIUrl":"https://doi.org/10.1038/s41430-025-01658-2","url":null,"abstract":"<p><strong>Aims: </strong>We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to a change in body weight, body composition, and muscle strength in children and young people with diabetes (CYPwD).</p><p><strong>Methods: </strong>Thirty-five CYPwD were recruited into this randomized controlled cross-over study (20 female; age 14.5 ± 2.9 years). The interventions were five and five weeks of ready-made food box deliveries of isocaloric diets in random order: either LCD (94.5 ± 4.7 g/day) or recommended carbohydrate diet (RCD) (191 ± 19.2 g/day). The outcomes were body weight and body mass index (BMI) standard deviation scores (SDS), body fat percentage assessed by bioimpedance and muscle strength assessed by jumping mechanography at the end of each dietary intervention. The Welch two-sample t-tests were used to determine the difference in outcomes.</p><p><strong>Results: </strong>At the end of the LCD period, the participants had significantly lower body weight and BMI SDS than at the end of the RCD period (61.7 kg vs. 62.6 kg, P < 0.001, and 22.3 kg/m² vs. 22.7 kg/m², P < 0.001) and (0.84 SD vs. 0.94 SD, P < 0.001, and 0.81 SD vs. 0.91 SD, P < 0.001). The body fat percentage was lower at the end of the LCD period (24.5% vs. 25.3%, P = 0.001). Dynamic muscle functions did not differ significantly at the end of the intervention periods.</p><p><strong>Conclusions: </strong>We demonstrated that a short-term low-carbohydrate diet is able to decrease body weight, BMI, and decrease the percentage of body fat in CYPwD without negatively affecting their muscle function.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary diversity and the risk of metabolic syndrome in a Japanese population: an analysis of baseline cross-sectional data from the J-MICC study.","authors":"Zin Wai Htay, Nobuaki Michihata, Yohko Nakamura, Yoshitaka Hippo, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Takashi Tamura, Mako Nagayoshi, Yasufumi Kato, Yudai Tamada, Asahi Hishida, Shiroh Tanoue, Daisaku Nishimoto, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Sakurako Katsuura-Kamano, Takeshi Watanabe, Kenji Wakai, Keitaro Matsuo","doi":"10.1038/s41430-025-01654-6","DOIUrl":"https://doi.org/10.1038/s41430-025-01654-6","url":null,"abstract":"<p><strong>Background: </strong>With the increasing burden of metabolic syndrome, it is crucial to focus on lifestyle factors to reduce the risk of metabolic syndrome.</p><p><strong>Objectives: </strong>This study aims to quantify the associations between dietary diversity and the risk of metabolic syndrome among the Japanese population.</p><p><strong>Methods: </strong>This study was conducted using baseline data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. The baseline survey was conducted from 2005 to 2014 by recruiting individuals aged 35-69. Information regarding dietary intake and biometric measurements were obtained. Dietary Diversity Score (DDS) was calculated from the data based on the food frequency questionnaire. A multiple logistic regression analysis was conducted to analyze the association between DDS and metabolic syndrome.</p><p><strong>Results: </strong>In total, 75,332 participants were included for analysis. Inverse associations were observed between a high DDS and metabolic syndrome (adjusted odds ratio, 0.83 [95% confidential interval 0.76-0.92]). Likewise, a high DDS was associated with reduced odds of a high body mass index and hypertension. No significant associations were observed between the DDS and serum triglyceride, fasting blood glucose, or high-density lipoprotein cholesterol values.</p><p><strong>Conclusion: </strong>The findings of this study emphasize that dietary diversity has inversed associations with metabolic syndrome. Promoting a diverse and balanced diet can be a potential strategy for mitigating the burden of metabolic syndrome.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fortification, folate and vitamin B12 balance, and the nervous system. Is folic acid excess potentially harmful?","authors":"Edward H Reynolds, Agata Sobczyńska-Malefora, Ralph Green","doi":"10.1038/s41430-025-01652-8","DOIUrl":"10.1038/s41430-025-01652-8","url":null,"abstract":"<p><p>The benefits of folic acid fortification are well known but less understood or acknowledged is the growing evidence of potential harms to the nervous system from excess folate, primarily because of a combination of fortification and/or high and sustained intake of folic acid supplements. We have summarised the historical, clinical, epidemiological and experimental evidence accumulated over the last 60 years in the pre and postfortification eras, which consistently and substantially suggests that excess folate, in particular in folic acid users, can have direct harms to the nervous system, especially in the presence of vitamin B12 deficiency. The harms are related both to the dose and duration of exposure to excess folic acid. Recent experimental evidence suggests that impaired cortical neurogenesis with excess folic acid is similar to that of folate or vitamin B12 deficiency and greatest when folate excess is present with vitamin B12 deficiency. Excess folate leads to a fall in vitamin B12 levels and aggravation of the block in folate metabolism resulting from vitamin B12 deficiency. The balance between folate and vitamin B12 is crucial to the functioning of one carbon metabolic pathways, the methylation cycle and ultimately to DNA and RNA structure and function, genetic and epigenetic stability. Vitamin B12 deficiency is an independent risk factor for NTDs and accounts for the increased risk of NTDs in some countries where B12 deficiency is more common than folate deficiency. A more prudent and balanced approach to fortification with folic acid, or preferably a natural reduced folate, combined with vitamin B12 would potentially improve the benefits and reduce the harms, including epigenetic and transgenerational risks, associated with current public health policies.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization-based dietary recommendations for healthy eating.","authors":"Xu-Wen Wang, Scott T Weiss, Frank B Hu, Yang-Yu Liu","doi":"10.1038/s41430-025-01655-5","DOIUrl":"https://doi.org/10.1038/s41430-025-01655-5","url":null,"abstract":"<p><p>Various diet scores have been developed to assess compliance with dietary guidelines. Yet, enhancing those diet scores is very challenging. Here, we tackle this issue by formalizing an optimization problem and solving it with simulated annealing. Our optimization-based dietary recommendation (ODR) approach, evaluated using Diet-Microbiome Association study data, provides efficient and reasonable recommendations for different diet scores. ODR has the potential to enhance nutritional counseling and promote dietary adherence for healthy eating.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of nutritional status and eating behaviours in patients with chronic inflammatory bowel disease: a pilot study.","authors":"Alice Scricciolo, Vincenza Lombardo, Karla Amada Bascuñán, Magdalena Araya, Luca Elli, Andrea Costantino, Rachele Gori, Giulia Gilberti, Flavio Caprioli, Gian Eugenio Tontini, Maurizio Vecchi, Federica Mascaretti, Luisa Doneda, Valentina Meschia, Leda Roncoroni","doi":"10.1038/s41430-025-01645-7","DOIUrl":"10.1038/s41430-025-01645-7","url":null,"abstract":"<p><strong>Background and aims: </strong>Ulcerative colitis (UC) and Crohn's disease (CD) are inflammatory bowel diseases (IBD) with varying clinical presentations. Current literature lacks specific dietary recommendations, though diets may serve as potential tools.</p><p><strong>Methods: </strong>This study, conducted at IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico of Milan from April 2020 to July 2022, aimed to evaluate the diets of UC and CD patients, focusing on preferred and avoided foods.</p><p><strong>Results: </strong>Results showed 67.4% and 80.9% of participants in remission by Mayo and HBI scores, respectively, with normal nutritional status and higher weight in CD versus UC patients and controls. Lactose-free diets were most common (21.3% UC, 17.4% CD, 11.6% controls), followed by gluten-free diets (23.4% UC, 13.4% CD, 9.3% controls). Low-FODMAPS diet adoption was minimal. Fibre avoidance was notable in CD (52%) and UC (45%) versus controls (5%). Pasta and bread consumption were high across groups. No dietary associations with disease activity or intergroup differences were found.</p><p><strong>Conclusions: </strong>The study population exhibited mild to moderate disease activity, normal nutritional status and prevalent dietary restrictions affecting nutrient intake and quality of life. Lactose-free diets were frequently employed, while gluten-free and low-FODMAPS diets were less common. Encouraging supervised fibre intake is recommended to prevent microbiota alterations negatively impacting intestinal health and homeostasis in IBD patients.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of kidney replacement therapy on indirect calorimetry in critically ill patients.","authors":"Annalena Knoll, Sirak Petros, Bastian Pasieka, Lorenz Weidhase","doi":"10.1038/s41430-025-01643-9","DOIUrl":"10.1038/s41430-025-01643-9","url":null,"abstract":"<p><strong>Background: </strong>Kidney replacement therapy (KRT) is frequently implemented in the intensive care unit. While measuring energy expenditure is recommended in the critically ill, the influence of KRT on indirect calorimetry (IC) is not fully clear. This prospective study aimed to investigate the influence of continuous veno-venous hemodialysis (CVVHD) and slow extended daily dialysis (SLEDD) on IC variables.</p><p><strong>Patients and methods: </strong>We included critically ill mechanically ventilated adult medical patients on KRT for acute kidney injury. CVVHD was run with regional citrate anticoagulation, while SLEDD with systemic heparin anticoagulation. We conducted IC twice on every patient, either immediately before the planned termination of KRT and then an hour after the end of KRT or immediately before commencement of KRT and then again after an hour on KRT.</p><p><strong>Results: </strong>We included 100 patients (75 males) with a median age of 64.0 years, a mean APACHE-II score of 30.9 and a mean SOFA score of 11.3 on the day of IC. There was no significant difference in median resting energy expenditure with versus without CVVHD (8029 [6993-9644] versus 7814 [6962-9304] kJ, p = 0.75) as well as with versus without SLEDD (9258 [8017-10,364] versus 9269 [8070-11,065] kJ, p = 0.63). The difference in resting energy expenditure between the two measurements was also not significant regardless of the sequence of IC measurements (p = 0.69).</p><p><strong>Conclusion: </strong>This prospective study on critically ill adult patients did not show any significant difference for indirect calorimetry variables between measurements conducted during CVVHD and SLEDD compared to those without KRT.</p><p><strong>Clinicaltrials: </strong>gov ID: NCT04599569.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}