Evangelia Damigou, Shauna M Downs, Christina Chrysohoou, Fotios Barkas, Costas Tsioufis, Christos Pitsavos, Evangelos Liberopoulos, Petros P Sfikakis, Demosthenes Panagiotakos
{"title":"Sustainable, planetary healthy dietary patterns are associated with lower 20-year incidence of cardiovascular disease: the ATTICA study (2002-2022).","authors":"Evangelia Damigou, Shauna M Downs, Christina Chrysohoou, Fotios Barkas, Costas Tsioufis, Christos Pitsavos, Evangelos Liberopoulos, Petros P Sfikakis, Demosthenes Panagiotakos","doi":"10.1038/s41430-025-01586-1","DOIUrl":"https://doi.org/10.1038/s41430-025-01586-1","url":null,"abstract":"<p><strong>Background/objectives: </strong>Nutrition epidemiology research scarcely focuses on the relationship between dietary patterns that are beneficial for both planet and human health. This study aimed to examine the association between adherence to a sustainable, planetary-healthy dietary pattern, i.e., the EAT-Lancet Reference Diet (EAT-LD), and 20-year cardiovascular disease (CVD) incidence, in a Mediterranean population.</p><p><strong>Subjects/methods: </strong>Τhe ATTICA study is a prospective cohort study with a baseline phase in 2002 and 3 consecutive follow-ups (in 2006, 2012, 2022). The EAT-Lancet Index (EAT-LI) and the MedDietScore scales were calculated based on previously published guidelines to assess the adherence to the respective dietary pattern. The current sample consisted of 1,988 Greek adults initially free-of-CVD at baseline. The development of a cardiovascular event was assessed throughout the 20-year period (WHO-ICD-10 classification).</p><p><strong>Results: </strong>The 20-year incidence of CVD was 3600 cases/10,000 individuals (95%Confidence Interval-CI: 3506 to 3695/10,000). Median (interquartile range) values for EAT-LI and MedDietScore were 17 (6.2) out of possible 42 points and 27 (2.9) out of possible 55 points, respectively. Both diet scales were inversely associated with 20-year CVD incidence [Hazard Ratio-HR (95% CI) per 1 point (of possible 42 points) of EAT-LI: 0.83 (0.77-0.90) and per 1 point (of possible 55 points) of MedDietScore: 0.90 (0.84-0.93)].</p><p><strong>Conclusion: </strong>Our findings highlight that diets that are good for planetary health, are also healthy for humans. Promoting diets that are culturally acceptable, economically viable, easily accessible, planet-friendly, and sustainable should be a key strategy for enhancing both public and planetary health.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of high-intensity interval rope-skipping on cardiorespiratory fitness, body composition, and enjoyment in young adults.","authors":"Wachirawit Phongchin, Suthana Tingsabhat, Ravisara Trongjitpituk, Thitipat Reun-Arom, Eric Tsz-Chun Poon, Waris Wongpipit","doi":"10.1038/s41430-025-01575-4","DOIUrl":"https://doi.org/10.1038/s41430-025-01575-4","url":null,"abstract":"<p><strong>Background/objective: </strong>Rope skipping is a cost-effective, moderate-to-vigorous-intensity aerobic exercise. While high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) are known to improve cardiorespiratory fitness (CRF) in labs, their effects in free-living conditions with rope skipping in young adults are unclear. The purpose of the study was to examine the effects of HIIE and MICE using rope skipping on CRF, body composition, and enjoyment in young adults.</p><p><strong>Subjects/methods: </strong>Fifty-nine healthy adults (29 females; aged 21.7 ± 2.5 years) were randomly assigned to HIIE (9 × 2-min bouts at 80% HRmax with 1-min active recovery), MICE (30-min at 70% HRmax), or a non-exercise control group (CONT). HIIE sessions occurred three times weekly, MICE five times weekly, over 8 weeks. Maximal oxygen uptake (a measure of CRF) was assessed both before and after the intervention. Enjoyment was evaluated using the Physical Activity Enjoyment Scale following the first and final sessions.</p><p><strong>Results: </strong>After 8 weeks, both HIIE [48.4 (43.9, 52.9) mL/kg/min; mean (95%CI)] and MICE [47.2 (43.1, 51.1) mL/kg/min] groups showed significantly better CRF than pretest [43.8 (38.8, 48.8) mL/kg/min, p < 0.001, and 42.2 (38.1, 46.2) mL/kg/min, p < 0.001, respectively] and the CONT group [39.9 (37.0, 42.8) mL/kg/min, p < 0.001, η<sup>2</sup>p = 0.595]. Body composition did not differ among or within groups. Enjoyment levels also did not differ between or within exercise groups.</p><p><strong>Conclusion: </strong>HIIE and MICE using rope skipping similarly enhanced CRF and provided comparable enjoyment in young adults. HIIE could be a time-efficient alternative to MICE for those with limited exercise time.</p><p><strong>Clinical trial registration: </strong>TCTR20220314004, thaiclinicaltrials.org.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing the Gaps in the Vitamin B12 Deficiency 2024 NICE Guidelines: Highlighting the Need for Better Recognition, Diagnosis, and Management of Pernicious Anaemia.","authors":"Alfie Thain, Kathryn Hart, Kourosh R Ahmadi","doi":"10.1038/s41430-025-01583-4","DOIUrl":"https://doi.org/10.1038/s41430-025-01583-4","url":null,"abstract":"<p><p>The 2024 NICE guidelines on vitamin B<sub>12</sub> deficiency have significant implications for the diagnosis and management of pernicious anaemia (PA), the commonest non-dietary cause of such deficiency. This perspective discusses the guidelines in relation to PA itself, suggests that clearer diagnostic protocols are required, and calls for clinician education to improve the patient journey for those with PA.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of GLIM-defined malnutrition with depressive mood in older adults undergoing rehabilitation.","authors":"Akio Shimizu, Keisuke Maeda, Junko Ueshima, Yuria Ishida, Tatsuro Inoue, Kenta Murotani, Ayano Nagano, Naoharu Mori, Tomohisa Ohno, Ichiro Fujisima","doi":"10.1038/s41430-025-01584-3","DOIUrl":"https://doi.org/10.1038/s41430-025-01584-3","url":null,"abstract":"<p><strong>Background/objectives: </strong>Depressive mood is prevalent in geriatric patients who undergo rehabilitation. Malnutrition, which frequently coexists in this demographic group, likely affects mental health status significantly. This study examined the association between malnutrition and depressive mood at discharge in geriatric patients who were undergoing rehabilitation and identified the mediating roles of specific malnutrition components in this association.</p><p><strong>Subjects/methods: </strong>This prospective cohort study comprised 189 geriatric rehabilitation patients. Malnutrition was determined using the Global Leadership Initiative on Malnutrition (GLIM) criteria, and depressive mood was assessed using the Geriatric Depression Scale-15 (GDS-15). The potential mediation of the GLIM components in the relationship between malnutrition and depressive mood was evaluated using causal mediation analysis.</p><p><strong>Results: </strong>Malnutrition was positively associated with increased GDS-15 scores at both admission (p = 0.007) and discharge (p < 0.001). The severity of malnutrition corresponded with increased odds of depressive mood at discharge (moderate malnutrition: odds ratio [OR] 3.84, 95% confidence interval [CI] 1.48-9.94, p = 0.005; severe malnutrition: OR 5.11, 95% CI 1.52-15.17, p = 0.003). Notably, both muscle mass reduction (OR 1.51, 95% CI 1.01-2.27, p = 0.042) and disease burden (OR 1.37, 95% CI 1.00-1.89, p = 0.047) were identified as mediators in the association between malnutrition and depressive mood at discharge.</p><p><strong>Conclusions: </strong>Nutritional status significantly influenced the mental health of geriatric rehabilitation patients, with muscle mass reduction and disease burden mediating this relationship. These findings emphasize the importance of a multidimensional geriatric rehabilitation approach that includes nutritional interventions.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The burden of prediabetes in low- and middle-income countries: a systematic review and meta-analysis.","authors":"Anjaly Joseph, Christian Sewor, Bhagiaswari Kodapally, Chanda Engred Manda, Jaison Joseph, Elezebeth Mathews","doi":"10.1038/s41430-025-01578-1","DOIUrl":"https://doi.org/10.1038/s41430-025-01578-1","url":null,"abstract":"<p><p>The global burden of diabetes is rising sharply, with a significant proportion of cases emerging in low- and middle-income countries (LMICs). Prediabetes, a condition characterized by elevated blood glucose levels that do not yet meet the threshold for diabetes, serves as a crucial stage for intervention and prevention. Despite its importance, comprehensive data on prediabetes prevalence in LMICs are sparse. Thus, we conducted a systematic review and meta-analysis to ascertain the prevalence of prediabetes in LMICs. We systematically reviewed studies on prediabetes in Low- and Middle-Income Countries (LMICs) from 1<sup>st</sup> January 2003 and 31<sup>st</sup> July 2024 using PubMed, Scopus, and Web of Science databases. The NIH study quality assessment tool assessed bias, and pooled prevalence was determined via a random-effects model. We examined publication bias through funnel plot analysis and Begg's and Egger's tests. The prevalence of prediabetes estimated from 164 studies conducted in LMICs was 13.1% (95% CI: 11.7%, 14.5%) based on the World Health Organization (WHO) criteria, and 27.0% (95% CI: 24.5%, 29.5%) based on the American Diabetes Association (ADA) criteria. The pooled prevalence did not significantly differ between males and females for both diagnostic criterias and by study design. The analysis indicated a noteworthy degree of heterogeneity in the pooled estimates (I2 > 70%; p < 0.05). The findings from this study indicated a higher burden of prediabetes within LMICs with regional variations.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Belinda Neo, Dale Tilbrook, Noel Nannup, Alison Daly, Eleanor Dunlop, John Jacky, Carol Michie, Cindy Prior, Brad Farrant, Carrington C J Shepherd, Anita S Lawrence, Edoardo Tescari, Lucinda J Black
{"title":"Quantifying vitamin D intake among Aboriginal and Torres Strait Islander peoples in Australia.","authors":"Belinda Neo, Dale Tilbrook, Noel Nannup, Alison Daly, Eleanor Dunlop, John Jacky, Carol Michie, Cindy Prior, Brad Farrant, Carrington C J Shepherd, Anita S Lawrence, Edoardo Tescari, Lucinda J Black","doi":"10.1038/s41430-025-01580-7","DOIUrl":"https://doi.org/10.1038/s41430-025-01580-7","url":null,"abstract":"<p><strong>Background/objective: </strong>Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] concentration < 50 nmol/L) is prevalent among Aboriginal and Torres Strait Islander peoples in Australia. Alternative to sun exposure (the primary source of vitamin D), vitamin D can also be obtained from food (e.g. fish, eggs, and meat) and supplements. However, the vitamin D intake of this population group is unknown. We aimed to provide the first quantification of vitamin D intake using nationally representative data from Aboriginal and Torres Strait Islander peoples.</p><p><strong>Methods: </strong>We used food consumption data collected in the 2012-2013 National Aboriginal and Torres Strait Islander Nutrition and Physical Activity Survey (n = 4109) and vitamin D food composition data to quantify vitamin D intake by sex, age group, and remoteness of location. Wilcoxon rank-sum test was used to assess the difference in vitamin D intake between sexes and remoteness of location.</p><p><strong>Results: </strong>The median (25th, 75th percentile) vitamin D intake among Aboriginal and Torres Strait Islander peoples aged ≥ 2 years was 80 (45, 145) IU/day. Vitamin D intake was statistically significantly different between males and females (p = < 0.001). There was no statistically significant difference between vitamin D intake in non-remote and remote areas (p = 0.292).</p><p><strong>Conclusions: </strong>Vitamin D intake among Aboriginal and Torres Strait Islander peoples is low. Food-based public health strategies guided by Aboriginal and Torres Strait Islander Elders and communities could be developed to promote higher vitamin D intake among this population.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prasangi Dabare, Pujitha Wickramasinghe, Indu Waidyatilaka, Sarita Devi, Maduka de Lanerolle Dias, Rajitha Wickremasinghe, Dulani Samaranayake, Ranil Jayawardena, Andrew P Hills, Pulani Lanerolle
{"title":"Validation of physical activity recall questionnaire and log using doubly-labelled water in Sri Lankan children.","authors":"Prasangi Dabare, Pujitha Wickramasinghe, Indu Waidyatilaka, Sarita Devi, Maduka de Lanerolle Dias, Rajitha Wickremasinghe, Dulani Samaranayake, Ranil Jayawardena, Andrew P Hills, Pulani Lanerolle","doi":"10.1038/s41430-025-01579-0","DOIUrl":"https://doi.org/10.1038/s41430-025-01579-0","url":null,"abstract":"<p><strong>Background and objective: </strong>Valid and cost-effective approaches are essential to assess physical activity and sedentary behaviours in individuals of all ages. This study aimed to validate a physical activity recall questionnaire (PAR-Q) and a physical activity log against the doubly labelled water (DLW) technique in 11-13-year-old Sri Lankan children.</p><p><strong>Method: </strong>Total energy expenditure (TEE) was determined using the criterion DLW technique (TEE<sub>DLW</sub>) and physical activity energy expenditure (PAEE<sub>DLW</sub>) was estimated. Subsequently, physical activity assessment methods were validated in a group of children (n = 79). PAR-Q was adapted from the adolescent physical activity questionnaire and the physical activity log from the Bouchard activity diary. The youth physical activity compendium was used to calculate PAEE from both PAR-Q (PAEE<sub>PAR-Q</sub>) and activity log (PAEE<sub>PALog</sub>). Statistical analysis included Pearson's correlation coefficient and Bland-Altman analyses.</p><p><strong>Results: </strong>Mean age of the study sample was 12.0 ± 0.8 years where the greater proportion were males (51.9%, n = 41). PAEE<sub>PAR-Q</sub> and PAEE<sub>PALog</sub> were significantly correlated with the PAEE<sub>DLW</sub> (r = 0.69 and r = 0.49, p < 0.05). PAR-Q underestimated PAEE by 230.1 ± 1071.1 kJ/day. Physical activity log overestimated PAEE by 14.6 ± 1283.2 kJ/day; for unit increase in the mean of the two measurements, the difference between the measurements increased by 0.48 (R<sup>2</sup> = 0.16, p < 0.001).</p><p><strong>Conclusion: </strong>PAR-Q is a valid tool for predicting PAEE in Sri Lankan children whereas the physical activity log was not. Researchers and practitioners can confidently use the PAR-Q to assess physical activity in this population, with potential applications in various research and intervention settings.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Longitudinal assessment of maternal micronutrients (folate and vitamin B<sub>12</sub>) and homocysteine levels in women who develop gestational diabetes mellitus.","authors":"Shweta Madiwale, Nikita Joshi, Karuna Randhir, Hemlata Pisal, Vrushali Kadam, Ghattu Krishnaveni, Girija Wagh, Sanjay Gupte, Caroline Fall, Sadhana Joshi","doi":"10.1038/s41430-025-01581-6","DOIUrl":"https://doi.org/10.1038/s41430-025-01581-6","url":null,"abstract":"<p><strong>Background: </strong>Micronutrients (folate and vitamin B<sub>12</sub>) and homocysteine are key components of the one-carbon metabolism and literature on the associations of these micronutrients with the pathophysiology of gestational diabetes mellitus (GDM) is unclear. The current study aims to examine the levels of these micronutrients across pregnancy in women who develop GDM and compare them with non-GDM women.</p><p><strong>Methods: </strong>A total of 200 pregnant women (100 Non-GDM and 100 GDM) were included in the study and blood samples were collected at 4 different time intervals throughout pregnancy (Visit-1 = 11-14 weeks, Visit-2 = 18-22 weeks, Visit-3 = 26-28 weeks, and Visit-4 = at delivery).</p><p><strong>Results: </strong>Vitamin B<sub>12</sub> levels at V3 and V4 (p = 0.031 and p = 0.001) and folate levels from V2, till delivery (p < 0.01 for V2, V3 and p = 0.025 for V4) were higher in GDM as compared to non-GDM. However, homocysteine levels were lower at all time points across gestation (p < 0.01 for all) in women with GDM. Intake of vitamin B<sub>12</sub> & folate rich foods was comparable in GDM and Non-GDM women. Also, the percentage of GDM women who took vitamin B<sub>12</sub> supplements was comparable between groups, while folate supplements were higher V1 (p < 0.01) in GDM women.</p><p><strong>Conclusions: </strong>Elevated micronutrients and lower homocysteine levels in GDM women necessitate more research for better understanding the role of these one carbon nutrients in the etiology of GDM and emphasizes the need to establish the optimum maternal vitamin B<sub>12</sub> and folate levels for fetal development.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Meta-analysis of the association between the dietary inflammatory index and risk of chronic kidney disease\" by Chen et al. 2024.","authors":"Amirhossein Ataei Kachouei, Frazam Kamrani, Fahimeh Haghighatdoost","doi":"10.1038/s41430-025-01582-5","DOIUrl":"https://doi.org/10.1038/s41430-025-01582-5","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernando Lamarca, Flávio T Vieira, Mariana S Melendez-Araújo, Ricardo M Lima, Eliane Said Dutra, Kênia Mara Baiocchi de Carvalho
{"title":"Resting energy expenditure of females mid- to long-term after bariatric surgery: agreement between indirect calorimetry and predictive methods.","authors":"Fernando Lamarca, Flávio T Vieira, Mariana S Melendez-Araújo, Ricardo M Lima, Eliane Said Dutra, Kênia Mara Baiocchi de Carvalho","doi":"10.1038/s41430-025-01577-2","DOIUrl":"https://doi.org/10.1038/s41430-025-01577-2","url":null,"abstract":"<p><strong>Background/objectives: </strong>Predictive equations estimate post-bariatric surgery resting energy expenditure (REE), but lack accuracy assessment, especially for the remaining body mass. This study aimed to evaluate the agreement between indirect calorimetry and REE predictive methods.</p><p><strong>Subjects/methods: </strong>It enrolled 226 females [median age 43.0 (36.2; 50.4) years] who underwent mid- to long-term post-Roux-en-Y gastric bypass [median postoperative time 6.1 (4.0; 9.0) years]. The measured REE (mREE) was obtained using indirect calorimetry, while the estimated REE (eREE) was derived from 18 predictive equations and an artificial neural network model. Analyses were performed for the total sample and body mass index (BMI) subgroups (<30 kg/m² and ≥30 kg/m²). eREE within ±10% of mREE was considered accurate; Bland-Altman plots were performed to evaluate agreement.</p><p><strong>Results: </strong>In the BMI < 30 kg/m² subgroup [n = 115; 1372 ± 153 kcal (5744.3 ± 640.6 kJ)], mREE did not differ from four predictive equations; Henry [1371 ± 95 kcal (5740.1 ± 397.8 kJ), p = 0.922, bias -1.0 kcal (-4.2 kJ)] and Dietary Reference Intakes-Institute of Medicine [1382 ± 102 kcal (5786.2 ± 427.1 kJ), p = 0.315, bias 10.2 kcal (42.7 kJ)] equations showed better agreement and accurate prediction performance among BMI categories (79.1 and 82.6%, respectively). The BMI ≥ 30 kg/m² subgroup mREE [n = 111; 1516 ± 186 kcal (6347.2 ± 778.7 kJ)] was significantly lower than all predictive methods and had higher bias and over-prediction, except for Mifflin-St Jeor equation [1523 ± 186 kcal (6376.5 ± 778.7 kJ), p = 0.469, bias 7.7 kcal (32.2 kJ)].</p><p><strong>Conclusion: </strong>Equations for estimating REE show wide performance variation, with limited accurate options in this population, especially among those with BMI > 30 kg/m².</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}