Association of breastfeeding duration with cardiac structure and function in 4 years old.

IF 3.3 3区 医学 Q2 NUTRITION & DIETETICS
Zhi Wang, Ling Yang, Bowen Du, Hualin Wang, Caifang Xu, Qianchuo Wang, Zhuoyan Li, Zhikang Xu, Hui Wang, Kun Sun, Jian Wang
{"title":"Association of breastfeeding duration with cardiac structure and function in 4 years old.","authors":"Zhi Wang, Ling Yang, Bowen Du, Hualin Wang, Caifang Xu, Qianchuo Wang, Zhuoyan Li, Zhikang Xu, Hui Wang, Kun Sun, Jian Wang","doi":"10.1038/s41430-025-01623-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Breast milk is an important source of nutrition for infant development. But few studies have investigated the relationship between breastfeeding duration and children's cardiac structure and function.</p><p><strong>Objectives: </strong>To assess the association of the duration of breastfeeding in infancy with cardiac structures and functions in 4-year-old children.</p><p><strong>Methods: </strong>The study analyzed data from 891 mother-offspring pairs in the Shanghai Birth Cohort (SBC) with complete 4-year follow-up and breastfeeding questionnaires. It excluded children with congenital heart defects or missing echocardiography data at age 4. Breastfeeding duration, including exclusive and mixed feeding, was categorized into three groups (<6months, 6-12months, >12months) based on questionnaires at 3 days, 24 days, 6, 12, and 24 months. Echocardiographic data were measured following 2010 American Society of Echocardiography recommendations.</p><p><strong>Results: </strong>The results showed that: compared to 4-year-old children who were breastfed for less than 6 months, those breastfed for more than 6 months had bigger left atrial and ventricular volume, including increased left atrial diastolic volume [LAVd (β: 2.09, 95% CI: 1.35, 2.83)], left atrial systolic volume [LAVs (β: 0.92, 95% CI: 0.53, 1.3)], left ventricular diastolic volume [LVEDV (β: 2.00, 95% CI: 0.36, 3.62)] and systolic volume [LVESV (β: 0.87, 95% CI: 0.17, 1.57)]. Children breastfed over 12 months showed similar cardiac structural changes as those breastfed 6-12 months. These findings were more pronounced in girls and low birthweight children.</p><p><strong>Conclusions: </strong>Four-year-old children who were breastfed for six months or more had increased left heart volume, and this association was influenced by gender and birthweight.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Clinical Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41430-025-01623-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Breast milk is an important source of nutrition for infant development. But few studies have investigated the relationship between breastfeeding duration and children's cardiac structure and function.

Objectives: To assess the association of the duration of breastfeeding in infancy with cardiac structures and functions in 4-year-old children.

Methods: The study analyzed data from 891 mother-offspring pairs in the Shanghai Birth Cohort (SBC) with complete 4-year follow-up and breastfeeding questionnaires. It excluded children with congenital heart defects or missing echocardiography data at age 4. Breastfeeding duration, including exclusive and mixed feeding, was categorized into three groups (<6months, 6-12months, >12months) based on questionnaires at 3 days, 24 days, 6, 12, and 24 months. Echocardiographic data were measured following 2010 American Society of Echocardiography recommendations.

Results: The results showed that: compared to 4-year-old children who were breastfed for less than 6 months, those breastfed for more than 6 months had bigger left atrial and ventricular volume, including increased left atrial diastolic volume [LAVd (β: 2.09, 95% CI: 1.35, 2.83)], left atrial systolic volume [LAVs (β: 0.92, 95% CI: 0.53, 1.3)], left ventricular diastolic volume [LVEDV (β: 2.00, 95% CI: 0.36, 3.62)] and systolic volume [LVESV (β: 0.87, 95% CI: 0.17, 1.57)]. Children breastfed over 12 months showed similar cardiac structural changes as those breastfed 6-12 months. These findings were more pronounced in girls and low birthweight children.

Conclusions: Four-year-old children who were breastfed for six months or more had increased left heart volume, and this association was influenced by gender and birthweight.

母乳喂养时间与4岁儿童心脏结构和功能的关系。
背景:母乳是婴儿发育的重要营养来源。但很少有研究调查母乳喂养时间与儿童心脏结构和功能之间的关系。目的:评估婴儿母乳喂养时间与4岁儿童心脏结构和功能的关系。方法:对上海出生队列(SBC)中891对母婴进行4年随访和母乳喂养问卷调查。该研究排除了4岁以下有先天性心脏缺陷或缺少超声心动图数据的儿童。根据3天、24天、6月、12月和24月的问卷调查,将母乳喂养时间(包括纯喂养和混合喂养)分为3组(12个月)。超声心动图数据是根据2010年美国超声心动图学会的建议测量的。结果:结果显示:与母乳喂养少于6个月的4岁儿童相比,母乳喂养超过6个月的儿童左心房和心室容积更大,包括左心房舒张容积[LAVd (β: 2.09, 95% CI: 1.35, 2.83)]、左心房收缩容积[LAVs (β: 0.92, 95% CI: 0.53, 1.3)]、左心室舒张容积[LVEDV (β: 2.00, 95% CI: 0.36, 3.62)]和收缩容积[LVESV (β: 0.87, 95% CI: 0.17, 1.57)]增加。母乳喂养超过12个月的儿童与母乳喂养6-12个月的儿童表现出相似的心脏结构变化。这些发现在女孩和低出生体重儿童中更为明显。结论:母乳喂养6个月或更长时间的4岁儿童左心容积增加,这种关联受性别和出生体重的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
10.60
自引率
2.10%
发文量
189
审稿时长
3-6 weeks
期刊介绍: The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信