European Journal of Clinical Nutrition最新文献

{"title":"When dietary patterns become identities: a new challenge for nutrition science.","authors":"Miguel López-Moreno, Nuria Perez-Diaz-Del-Campo","doi":"10.1038/s41430-026-01837-9","DOIUrl":"https://doi.org/10.1038/s41430-026-01837-9","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status and associated factors among children aged 6-24 months at a primary health care centre in conflict-affected Gaza.","authors":"Lina Murtaja, Hamza Abdeljawad, Ahmed Najim, Josie Rodgers, Reham Almukbel, Kinan Mokbel","doi":"10.1038/s41430-026-01836-w","DOIUrl":"https://doi.org/10.1038/s41430-026-01836-w","url":null,"abstract":"<p><strong>Background/objectives: </strong>Children aged 6-24 months are highly vulnerable to malnutrition during conflict because they depend on breastfeeding, complementary feeding and functioning nutrition services. This study assessed nutritional status, socioeconomic correlates, maternal knowledge and primary health care centre (PHCC) nutrition service gaps in Gaza.</p><p><strong>Subjects/methods: </strong>This cross-sectional study was conducted at Al-Daraj Martyrs Health Centre, one of the remaining functioning PHCCs in Gaza City during the study period, between late August and October 2025. Mother-child pairs were recruited by convenience sampling. Of 276 mother-child pairs approached, 250 completed the questionnaire. The anthropometric analytic sample comprised 200 children with the required anthropometric information, while haemoglobin results were available for 55 of the 250 completed participants.</p><p><strong>Results: </strong>Stunting affected 12.5% of children, underweight 20.1%, wasting 20.8%, and anaemia 63.6% of the haemoglobin-tested subsample. Underweight was associated with household food shortage (p = 0.013) and previous malnutrition treatment (p = 0.002), wasting with child age category (p = 0.0024), and anaemia with paternal unemployment (p = 0.020). Maternal knowledge and practice scores were positively correlated (r = 0.177, p = 0.012), but neither was independently associated with stunting or underweight in adjusted models. PHCC nutrition support was limited, with 71.0% of mothers reporting nurse-provided nutrition advice and 52.5% reporting growth-chart review.</p><p><strong>Conclusion: </strong>In this clinic-based sample from conflict-affected Gaza, malnutrition among children aged 6-24 months was substantial. The pattern suggests that nutritional risk was shaped more by structural deprivation and weakened PHCC support than by maternal knowledge alone. These findings underline the need to restore nutrition services and improve access to adequate food for young children.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of sarcopenic obesity at hospital admission according to ESPEN-EASO approach on functional status of older adults: results of a retrospective and prospective observational study.","authors":"Gianluca Gortan Cappellari, Rocco Barazzoni, Nicola Veronese, Paolo De Colle, Giuseppe Castiglia, Matteo Bianchini, Carlo Cortese, Sabrina Rampazzo, Anna Rizza, Giovanni Zampieri, Michela Zanetti","doi":"10.1038/s41430-026-01835-x","DOIUrl":"https://doi.org/10.1038/s41430-026-01835-x","url":null,"abstract":"<p><strong>Background/objectives: </strong>Sarcopenic obesity (SO) is associated with adverse outcomes. This study aimed to assess the prevalence of SO diagnosed using the ESPEN-EASO approach and its correlations with functional impairment in an acute geriatric setting.</p><p><strong>Subjects/methods: </strong>Observational study including 453 older adults admitted to a Geriatric Unit. According to the ESPEN-EASO approach, patients were screened for obesity (BMI), assessed for handgrip strength (HGS, dynamometry), and body composition (bioimpedance analysis). SO was defined by low HGS, reduced relative to body weight skeletal muscle mass (SMM%), and increased relative fat mass (FM%). Screen-positive patients not meeting SO criteria were classified as obese (OB). Screen-negative patients with low SMM% and HGS were defined as sarcopenic (SARC); the remaining served as control (NS-NO). Functional status was investigated by IADL and by basal ADL collected at admission, during hospitalization, and at discharge and analyzed using trajectory modeling and univariate and multivariate adjusted models.</p><p><strong>Results: </strong>Among enrolled patients (mean age: 84.9 ± 7.0 y, F: 236, 52.1%), 36 (7.9%) had SO, 65 (14.3%) OB, 98 (21.0%) SARC, and 254 (56.7%) NS-NO. In multivariate analyses (NS-NO as reference) only SO demonstrated an increased risk of impaired ADL at discharge while OB and SARC did not. Trajectory modeling confirmed an SO-specific association with functional impairment followed by lower ADL recovery. Age, malnutrition, and cognitive impairment were independently associated with reduced ADL at admission and at discharge and with IADL.</p><p><strong>Conclusions: </strong>Sarcopenic obesity is associated with a higher risk of poor ADL at discharge, emphasizing the importance of personalized obesity phenotyping in hospitalized older adults.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional intake on dialysis and non-dialysis days and the effect of intradialytic food provision among hemodialysis patients, a single-center study.","authors":"Haalah Shaaker, Andrew Davenport","doi":"10.1038/s41430-026-01833-z","DOIUrl":"https://doi.org/10.1038/s41430-026-01833-z","url":null,"abstract":"<p><strong>Background/objectives: </strong>Patients receiving hemodialysis (HD) are at risk of malnutrition due to the considerable time required to attend dialysis, which may reduce food intake on dialysis days (DDs). We assessed dietary intake on one DD and two non-dialysis days (NDDs) and the impact of intradialytic food consumption on nutritional status.</p><p><strong>Subjects/methods: </strong>We conducted a cross-sectional study of 60 HD outpatients using the Global Leadership Initiative on Malnutrition criteria, dietary records, and bioimpedance analysis to assess nutritional intake and status.</p><p><strong>Results: </strong>Their mean age was 62 ± 14 years; 65% were male, 27% had sarcopenia, 67% were frail, and one-third were classified with malnutrition. Three-day averaged dietary records showed that only 8% met the Kidney Disease Outcomes Quality Initiative energy and protein recommendations; both were lower on the DD compared with NDDs: 14.8 (10.7-22.3) vs 16.3 (13.3-22.9) kcal/kg/day (p = 0.018) and 0.72 ± 0.35 vs 0.87 ± 0.38 g/kg/day (p = 0.001), respectively. Forty-three percent brought food on the DD, and their energy and protein intakes did not differ between the DD and NDDs. In contrast, those who did not bring food had lower energy (p < 0.001) and protein intakes (p < 0.001) on the DD. Patients who brought food did not experience any greater peri-dialytic hypotension (n = 10, 38% vs n = 14, 41%), despite lower extracellular water-to-total body water ratios (p = 0.007).</p><p><strong>Conclusion: </strong>Nutritional intake remains suboptimal in many hemodialysis patients, particularly on DDs. These findings suggest that providing or bringing food during dialysis may help improve or maintain nutritional intake. However, longitudinal studies are required to confirm these findings.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bioelectrical impedance analysis (BIA) international database: an update and ongoing call for data.","authors":"Analiza M Silva, Gil B Rosa, Tiago R Silva, Federica Frau, Jonathan Ck Wells, Elisabetta Marini, Leigh C Ward","doi":"10.1038/s41430-026-01828-w","DOIUrl":"https://doi.org/10.1038/s41430-026-01828-w","url":null,"abstract":"<p><p>The Bioelectrical Impedance Analysis International Database (BIAID) is an initiative aimed at pooling, standardizing and harmonizing bioelectrical impedance analysis (BIA) data across populations. This report provides a synthesis of the data currently available in the BIAID and an overview of the actions undertaken to date. The repository, which is based on raw bioelectrical values as minimal required data, has expanded over the past two years to include 321,680 individuals across the lifespan, encompassing both healthy and clinical populations and representing all WHO regions. A methodological questionnaire was also implemented to assess data quality and measurement protocols across contributing centers. To date, several research proposals using BIAID data have been approved, reflecting increasing scientific interest and use of the database. Continued data sharing and collaboration are essential to enhance the robustness, representativeness and global applicability of the database, promoting high-quality and reproducible research in nutritional science.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food frequency questionnaires are ranking tools, not rulers: a measurement problem hiding in plain sight.","authors":"Jimmy Chun Yu Louie, Jahar Bhowmik","doi":"10.1038/s41430-026-01834-y","DOIUrl":"https://doi.org/10.1038/s41430-026-01834-y","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperammonaemic encephalopathy following bariatric surgery: detailed biochemical phenotyping and pathophysiology informed treatment.","authors":"Jeremy Clark, George Roubos, Elaine Jayadiwangsa, Luke Ephraums, David Russell, Timothy Fazio","doi":"10.1038/s41430-026-01830-2","DOIUrl":"https://doi.org/10.1038/s41430-026-01830-2","url":null,"abstract":"<p><p>Hyperammonaemic encephalopathy is a rare and potentially devastating complication following bariatric surgery. Recognition of the pathology and understanding of pathophysiology are essential to effective treatment. Three patients with symptoms and biochemical changes suggestive of small intestinal bacterial overgrowth (SIBO) following gastric bypass developed relapsing hyperammonaemic encephalopathy. Severe protein malnutrition and biochemical dysfunction of the urea cycle were noted on biochemical testing. Hyperammonemia in all three patients did not respond to empiric therapy for a potential genetic urea cycle disorder. Successful treatment was dependent upon adequate therapy for SIBO in the bypassed small bowel loop and a period of parenterally delivered nutrition. Uncontrolled weight loss was able to be arrested. Hyperammonaemic encephalopathy after bariatric surgery is driven by SIBO and subsequent protein-energy malnutrition. These two preconditions cause increased delivery of ammonia to the urea cycle and cellular dysfunction of the urea cycle. Treatment of these preconditions informs management priorities.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single centre experience of refeeding hypophosphataemia and refeeding syndrome in parenteral nutrition and a proposal for a sub-fulminant categorisation.","authors":"Luka Kablar, Simon Hill, Richard Swift, Russell Walmsley","doi":"10.1038/s41430-026-01829-9","DOIUrl":"https://doi.org/10.1038/s41430-026-01829-9","url":null,"abstract":"<p><strong>Background: </strong>Refeeding syndrome (RFS) is an uncommon, but potentially serious, complication of nutrition therapy. There remains a lack of consensus as to the clinical definition of RFS and refeeding hypophosphataemia (RH), and what measures should be included to assess risk. This study aims to evaluate the prevalence of RH and RFS using previously proposed criteria in our cohort of patients receiving parenteral nutrition (PN), and assess the National Institute for Health and Care Excellence guidelines as risk factors.</p><p><strong>Methods: </strong>A single-centre prospective cohort study of adult patients (age ≥18 years) receiving PN for more than 48 h over a 5 year period. Prevalence of RH was determined using four previously established diagnostic criteria and RFS by the King's College criteria. Risk factors were assessed using univariate analysis and multiple logistic regression.</p><p><strong>Results: </strong>354 cases fulfilled the inclusion criteria. 4.5-13.3% (17-47 of the 354 cases) met at least one of the criteria for RH. No cases met the criteria for RFS. Thirteen (3.7%) cases with RH manifested signs of fluid overload without an alternative explanation except possible refeeding syndrome. Weight loss above 10% over 3-6 months (P = 0.03), serum albumin (P = 0.02), and serum haemoglobin (P = 0.01) were factors associated with RH.</p><p><strong>Conclusion: </strong>Prevalence of RH varies considerably according to the established criteria used, but overall remains uncommon. Previously defined RFS was not seen in our cohort of patients. A combination of RH and fluid overload without an alternative cause may represent sub-fulminant RFS.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographically clustered dietary patterns associated with body mass index among nationally represented adults in Malaysia: a substitution analysis.","authors":"Kimberly Yuin Y'ng Wong, Foong-Ming Moy, Sanjay Rampal","doi":"10.1038/s41430-026-01831-1","DOIUrl":"https://doi.org/10.1038/s41430-026-01831-1","url":null,"abstract":"<p><strong>Background: </strong>Despite the rising prevalence of obesity, evidence on geographically specific dietary patterns and the potential impact of healthier dietary shifts remains limited. This study therefore aims to identify spatial clustering of dietary patterns and use substitution analysis to estimate the effect of a dietary pattern shift on body mass index (BMI).</p><p><strong>Methods: </strong>Information from the Malaysian Adult Nutrition Survey (MANS) 2014 (n = 2574) were utilised. Dietary patterns were identified using principal component analysis of 17 food groups, and Bartlett scores were derived. Global and Local Moran's I with an egocentric distance of 8 km or five nearest neighbours assessed general and local clustering of the dietary pattern scores, respectively. Direct and substitutive associations between dietary patterns and BMI accounted for hierarchical data structure and socio-demography factors.</p><p><strong>Results: </strong>Three dietary patterns explaining 36.0% of the variance were identified and labelled as Western, Healthier, and Traditional diets. Significant spatial clustering was observed for all dietary patterns, with the Western diet showing the weakest clustering. Healthier diets predominated in higher-income urban areas, whereas the Traditional diet clustered in lower-income areas. Energy-adjusted Traditional diet score was positively associated with BMI (β = 0.40 kg/m²; p < 0.01), while substituting it with Healthier diet was inversely associated (β = -0.8 kg/m²; p < 0.05).</p><p><strong>Conclusion: </strong>This study presents a novel application of substitution analysis on the association between dietary pattern and BMI across a multi-ethnic population. The findings reveal geographically distinct dietary patterns linked to BMI, underscoring the need for localised nutrition and obesity prevention strategies.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin B12 absorption and factors associated with the response to long-term oral B12 supplementation: a secondary analysis of data from a B12-deficient Indian rural community.","authors":"Chittaranjan S Yajnik, Urmila S Deshmukh, Dattatray S Bhat, Rucha Sh Wagh, Onkar A Deshmukh, Rasika Ladkat, Lindsay D Plank, Souvik Bandyopadhyay, Caroline H Fall, Helga Refsum, Elaine C Rush","doi":"10.1038/s41430-026-01825-z","DOIUrl":"https://doi.org/10.1038/s41430-026-01825-z","url":null,"abstract":"<p><strong>Background: </strong>The absorption of oral vitamin B12 (B-12) and predictors of its long-term supplementation are not well understood in populations with B-12 insufficiency.</p><p><strong>Objective: </strong>In a secondary data analysis of a B-12 absorption study and a supplementation trial in a B-12 insufficient rural Indian community, we examined (i) the distribution of plasma holotranscobalamin (holoTC) responses during an absorption test, and (ii) predictors of B-12 status during long-term, oral supplementation with physiological and near-physiological doses of B-12.</p><p><strong>Methods: </strong>Participants in the Pune Maternal Nutrition Study first underwent a B-12 absorption study (CobaSorb protocol) and subsequently participated in a 12-month double-blind randomized controlled trial of daily oral B-12 (0, 2, or 10 µg cyanocobalamin) and folic acid (0 or 200 µg). Plasma holoTC responses during absorption test were characterized, and linear mixed-effects models used to identify predictors of B-12 absorption and response during long-term supplementation.</p><p><strong>Results: </strong>Participants (313) included children (n = 109, mean age 9 y, weight 21.9 kg, BMI 13.6 kg/m²), mothers (n = 108, 30 y, 47.7 kg, 19.3 kg/m²), and fathers (n = 96, 37 y, 59.3 kg, 21.4 kg/m²). The holoTC response during the absorption test was positively associated with the B-12 dose (10 or 2 µg) and negatively with body weight. Improvements in B-12 status (plasma B-12, tHcy, combined B-12 indicator: 2cB12) after supplementation were positively predicted by baseline biomarker concentration, holoTC response during absorption test, B-12 dose, and compliance.</p><p><strong>Conclusions: </strong>The holoTC response during B-12 absorption test predicted subsequent biomarker responses to long-term B-12 supplementation, linking absorptive capacity with metabolic correction. These findings provide a mechanistic framework for understanding variability in response to oral B-12 replenishment.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}