European Journal of Clinical Nutrition最新文献

{"title":"Association between beverage quality with sleep disorders and quality of life: a cross-sectional study.","authors":"Kimia Leilami, Seyedhassan Sadrian, Zahra Ghazimoradi, Zahra Rezaei, Atefeh Torabi Ardekani, Morteza Zare, Seyed Jalil Masoumi","doi":"10.1038/s41430-025-01624-y","DOIUrl":"10.1038/s41430-025-01624-y","url":null,"abstract":"<p><strong>Background/objectives: </strong>The interplay between beverage consumption patterns and critical aspects of health, such as quality of life (QoL) and sleep disorders, has been increasingly recognized. This study is essential as it explores how the Healthy Beverage Index (HBI) and Healthy Beverage Score (HBS) relate to sleep disorders and QoL in a diverse adult population, highlighting their impact on various health aspects.</p><p><strong>Subjects/methods: </strong>A cross-sectional analysis was conducted using data from the Shiraz University of Medical Sciences Employees Health Cohort Study (SUMS EHCS), encompassing 3380 participants aged 20-65. Data collection included a 119-item Food Frequency Questionnaire (FFQ) and comprehensive anthropometric, lifestyle, and health-related assessments. HBI and HBS were computed to evaluate beverage consumption patterns, and their associations with sleep quality and QoL were analyzed using logistic regression models.</p><p><strong>Results: </strong>Higher HBI scores were significantly associated with 16% improved QoL (OR: 1.16, 95% CI: 1.02-1.29, p = 0.034) and a 17% reduced risk of sleep disorders (OR = 0.83, 95% CI: 0.69-0.99, p = 0.039). However, HBS did not significantly correlate with QoL or sleep quality.</p><p><strong>Conclusion: </strong>As indicated by higher HBI scores, the findings emphasize that promoting healthier beverage choices could enhance sleep quality and overall life satisfaction.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dietary fiber on trimethylamine-N-oxide production after beef consumption and on gut microbiota: MEATMARK - a randomized cross-over study.","authors":"Melanie Haas, Beate Brandl, Klaus Neuhaus, Susanne Wudy, Karin Kleigrewe, Hans Hauner, Thomas Skurk","doi":"10.1038/s41430-025-01636-8","DOIUrl":"10.1038/s41430-025-01636-8","url":null,"abstract":"<p><strong>Background/objectives: </strong>The gut-microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) has been linked to cardiovascular disease (CVD) risk, while dietary fiber is associated with reduced CVD risk and improved gut health. Considering these associations, we conducted a randomized, double-blind, pilot study to investigate the influence of fiber supplementation on intestinal TMAO formation after beef consumption.</p><p><strong>Subjects/methods: </strong>13 volunteers underwent a two-week dietary fiber and placebo intervention. We assessed the effect of fiber supplementation on the gut microbiota and gene abundance of the enzyme cutC, a key enzyme for microbial TMA formation, a precursor for TMAO. We measured the TMAO response following beef consumption after the two-week intervention. We also examined the role of hepatic enzyme FMO3 on TMAO plasma levels.</p><p><strong>Results: </strong>Although overall TMAO production did not change between the dietary fiber and placebo group (p-value = 0.26, 95% CI), subgroup analysis revealed that fiber supplementation attenuated TMAO formation following beef intake in participants with lower habitual meat consumption ( <3 times/week, p-value = 0.029, 95% CI). Furthermore, fiber intervention significantly downregulated microbial cutC gene abundance (p = 0.034, 95% CI), suggesting a mechanism by which fiber might reduce plasma TMAO levels. While dietary fiber intervention did not alter TMAO production across all participants, it showed a potential effect in individuals with lower habitual meat intake. The observed downregulation of cutC gene abundance suggests a mechanism for the beneficial impact of fiber on TMAO formation.</p><p><strong>Conclusion: </strong>These findings support the role of a high-fiber, low-meat diet as a promising strategy to mitigate TMAO-related CVD risk. Graphical abstract of the MEATMARK study. Created with BioRender.com. Haas, M. (2025) https://BioRender.com/x12v771 .</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of breastfeeding duration with cardiac structure and function in 4 years old.","authors":"Zhi Wang, Ling Yang, Bowen Du, Hualin Wang, Caifang Xu, Qianchuo Wang, Zhuoyan Li, Zhikang Xu, Hui Wang, Kun Sun, Jian Wang","doi":"10.1038/s41430-025-01623-z","DOIUrl":"https://doi.org/10.1038/s41430-025-01623-z","url":null,"abstract":"<p><strong>Background: </strong>Breast milk is an important source of nutrition for infant development. But few studies have investigated the relationship between breastfeeding duration and children's cardiac structure and function.</p><p><strong>Objectives: </strong>To assess the association of the duration of breastfeeding in infancy with cardiac structures and functions in 4-year-old children.</p><p><strong>Methods: </strong>The study analyzed data from 891 mother-offspring pairs in the Shanghai Birth Cohort (SBC) with complete 4-year follow-up and breastfeeding questionnaires. It excluded children with congenital heart defects or missing echocardiography data at age 4. Breastfeeding duration, including exclusive and mixed feeding, was categorized into three groups (<6months, 6-12months, >12months) based on questionnaires at 3 days, 24 days, 6, 12, and 24 months. Echocardiographic data were measured following 2010 American Society of Echocardiography recommendations.</p><p><strong>Results: </strong>The results showed that: compared to 4-year-old children who were breastfed for less than 6 months, those breastfed for more than 6 months had bigger left atrial and ventricular volume, including increased left atrial diastolic volume [LAVd (β: 2.09, 95% CI: 1.35, 2.83)], left atrial systolic volume [LAVs (β: 0.92, 95% CI: 0.53, 1.3)], left ventricular diastolic volume [LVEDV (β: 2.00, 95% CI: 0.36, 3.62)] and systolic volume [LVESV (β: 0.87, 95% CI: 0.17, 1.57)]. Children breastfed over 12 months showed similar cardiac structural changes as those breastfed 6-12 months. These findings were more pronounced in girls and low birthweight children.</p><p><strong>Conclusions: </strong>Four-year-old children who were breastfed for six months or more had increased left heart volume, and this association was influenced by gender and birthweight.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectrical impedance vector analysis and phase angle in response to resistance training volume reduction in older women.","authors":"Melissa Antunes, Leandro Dos Santos, Luís Alberto Gobbo, Analiza M Silva, Paolo M Cunha, Witalo Kassiano, Letícia T Cyrino, Hellen C G Nabuco, Ricardo J Rodrigues, Luís B Sardinha, Edilson S Cyrino","doi":"10.1038/s41430-025-01635-9","DOIUrl":"https://doi.org/10.1038/s41430-025-01635-9","url":null,"abstract":"<p><strong>Background: </strong>Bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) are important for monitoring hydration, muscle function, and quality of life in older adults. Resistance training (RT) can counteract aging's adverse effects on cellular integrity and function.</p><p><strong>Objective: </strong>This study compared the effects of RT volume reduction on BIVA and PhA in physically independent older women. Sixty-seven participants (>60 years) underwent a 20-week standardized whole-body RT program (eight exercises, three sets each, 8-12 repetitions, three non-consecutive days per week in the morning). They were then randomly assigned to one of the three eight-week training conditions following the training model described above: reduced volume to one set (RV1, n = 22), two sets (RV2, n = 24), or maintained volume (MV, n = 21). Bioimpedance spectroscopy measured total body water (TBW), intracellular (ICW), and extracellular (ECW) water, BIVA, and PhA based on resistance (R), impedance (Z), reactance (Xc), and height (H). All groups showed significant increases in TBW, ICW, and ECW during the volume reduction phase (P < 0.05).</p><p><strong>Results: </strong>R, R/H, Z, and Z/H decreased across all groups, with significant changes from the pre-conditioning phase in the RV1 and RV2 groups (P < 0.05). Xc and Xc/H increased during the pre-conditioning phase across all groups and returned to baseline during the volume reduction phase (P < 0.05). PhA increased during the pre-conditioning and was maintained during the volume reduction phase (RV1 = +0.33°, RV2 = +0.50°, MV = +0.47°; P < 0.05).</p><p><strong>Conclusion: </strong>These results suggest that reducing RT volume by up to one-third can still improve PhA, BIVA, and hydration status in older women.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acute effects of moderate-intensity continuous or high-intensity interval exercise on appetite and appetite-related hormones in South Asian and white European adults with non-diabetic hyperglycaemia.","authors":"Tonghui Shen, Alice E Thackray, Jack A Sargeant, Thomas Yates, James A King, Scott A Willis, David J Stensel","doi":"10.1038/s41430-025-01633-x","DOIUrl":"https://doi.org/10.1038/s41430-025-01633-x","url":null,"abstract":"<p><strong>Objective: </strong>To compare acute effects of continuous moderate-intensity exercise (CME) and low-volume high-intensity interval exercise (LV-HIIE) on appetite responses between South Asians and white Europeans with non-diabetic hyperglycaemia.</p><p><strong>Methods: </strong>Thirteen white Europeans and 10 South Asians (age 50-74 years) completed three, 5-h experimental conditions (CME, LV-HIIE, control) in randomised sequences. Standardised meals were provided at 0 and 3 h. Exercise involved a 25-min LV-HIIE or 35-min CME bout that ended at 2 h. Subjective appetite perceptions and appetite-related hormones (glucagon-like peptide-1 (GLP-1), peptide YY (PYY), acylated ghrelin (AG)) were measured at 0, 0.5, 1, 2, 3, 3.5, 4 and 5 h. Time-averaged total area under the curve (TAUC; 1-5 h) was analysed, adjusted for age, sex, and pre-intervention time-averaged TAUC (0-1 h).</p><p><strong>Results: </strong>Total GLP-1 was higher in LV-HIIE (mean difference [95% CI] 4.3 [1.5, 7.1] pmol/L h) and CME (4.5 [1.4, 7.7] pmol/L h) versus control (condition effect P = 0.01), but exercise had no effect on the other outcomes in the whole study population (P ≥ 0.28). Appetite responses to exercise were similar between ethnicities for total GLP-1 and total PYY (interaction P ≥ 0.11), but subtle differences emerged for AG and overall appetite (interaction P ≤ 0.02). AG was higher and overall appetite lower in LV-HIIE versus CME in South Asians whilst overall appetite was higher in LV-HIIE versus CME in white Europeans, but neither exercise bout was different to control.</p><p><strong>Discussion: </strong>Single LV-HIIE and CME bouts increased total GLP-1 in individuals with non-diabetic hyperglycaemia, but exercise-related appetite responses were not strongly modulated by exercise intensity or ethnicity.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARFID and a twist of lime- unravelling a case of paediatric scurvy.","authors":"Amer Abdul Qaiyum, Maliha Salim, Mohammed Abdelrehiem, Leanne Royle, Sarah Maltby","doi":"10.1038/s41430-025-01634-w","DOIUrl":"https://doi.org/10.1038/s41430-025-01634-w","url":null,"abstract":"<p><p>Scurvy, considered an ancient disease, is now being seen in children with restricted nutritional intake. Often children have vague symptoms which warrant thorough investigations to rule out more serious causes. The diagnostic uncertainty, extensive investigations and prolonged hospitalization has significant impact on child's development. We have presented a case of scurvy in a 7-year-old boy, known to have ARFID with progressive lower limb pain, weakness, limp and inability to bear weight for 5 weeks which have previously been reported in literature. However, this case was complicated by variable neurological findings during his admission. Scurvy was considered and diagnosed much later in the disease course after ruling out more sinister causes. Main learning points of this case were to have a high index of suspicion for Scurvy in children with restricted intake, and to improve surveillance and monitoring for nutritional deficiencies in these patients.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stunted African toddlers digest and obtain energy from energy-dense thick sorghum porridge.","authors":"Fatimata Cisse, Clay Swackhamer, Hawa G Diall, Atossa Rahmanifar, Mariam Sylla, Antone R Opekun, Michael A Grusak, Amy H-M Lin, Elizabeth A Pletsch, Anna M R Hayes, Roberto Quezada-Calvillo, Buford L Nichols, Bruce R Hamaker","doi":"10.1038/s41430-025-01632-y","DOIUrl":"https://doi.org/10.1038/s41430-025-01632-y","url":null,"abstract":"<p><strong>Background/objectives: </strong>Increasing the energy density of porridges could help meet the needs of moderately malnourished, stunted children. However, it is not clear whether stunted toddlers can adequately digest and obtain energy from energy-dense porridges with thick texture. A clinical study was conducted in Bamako, Mali, using ¹³C-labeled substrates and serial breath sampling to determine whether stunted toddlers differed from healthy toddlers in their capacity to digest thick and thin sorghum porridges.</p><p><strong>Subjects/methods: </strong>Experimental porridges, including a traditional porridge (control), a starch-enriched calorie-dense thick porridge, and an α-amylase-thinned calorie-dense porridge, were fed to stunted (n = 24) and healthy (n = 24) 18-30-month toddlers. Breath test results were expressed as Percent Dose Recovery and curve fit using the Weibull function to determine the kinetics of starch digestion.</p><p><strong>Results: </strong>The stunted and healthy toddlers were able to digest and oxidize the starch from traditional porridge equally well, with no statistically significant differences between the kinetic parameters of the two groups. After consumption of thickened porridge, healthy toddlers had slightly faster starch digestion kinetics with PDR curves rising more rapidly (p < 0.05) and peaking earlier in the postprandial period (p < 0.01) for healthy individuals than for stunted individuals, yet these groups did not have differences in the overall extent of starch digestion, as their final CPDR values were not significantly different. Gastric emptying rate did not differ significantly between the healthy and stunted groups.</p><p><strong>Conclusion: </strong>Overall, we found that thick porridge supplied digestible carbohydrates to stunted and healthy toddlers, as well as thinned calorie-dense porridge.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise conducted prior to phenylketonuria-type meal on appetite, satiety hormones and energy expenditure: a randomised cross-over trial.","authors":"Nouf A Alghamdi, James L Dorling, Abdulrahman Alreshidi, Konstantinos Gerasimidis, Dalia Malkova","doi":"10.1038/s41430-025-01629-7","DOIUrl":"https://doi.org/10.1038/s41430-025-01629-7","url":null,"abstract":"<p><strong>Background/objectives: </strong>Individuals with phenylketonuria (PKU) are at increased risk for obesity, possibly due to reduced satiety induced by a PKU diet that is low protein and high carbohydrate. It is unclear how exercise alters postprandial satiety after a PKU-like meal. The objective was to examine changes in postprandial satiety, satiety hormone concentrations, energy expenditure and substrate oxidation in response to acute treadmill exercise following a PKU-like meal.</p><p><strong>Subjects/methods: </strong>Sixteen males (mean age [±SD]: 26.5 ± 4.8 years; BMI: 23.7 ± 3.2 kg/m²) participated in a randomized cross-over trial with two conditions: exercise and control. Both trials involved consuming a PKU-like meal comprising naturally low-protein foods, a special low-protein food and a protein substitute. In the exercise trial, participants exercised at 60% of maximal oxygen uptake for 1 h before the meal; in the control trial, they rested. Satiety agents (peptide YY [PYY], glucagon-like peptide-1 [GLP-1] and growth differentiation factor-15 [GDF-15]), appetite, energy expenditure, fat oxidation and carbohydrate oxidation were measured.</p><p><strong>Results: </strong>Mean (±SE) appetite and postprandial PYY and GLP-1 concentrations were unaffected by exercise (P ≥ 0.279). However, GDF-15 was higher in the exercise trial (control: 288 ± 25 pg/mL vs. exercise: 322 ± 24 pg/mL; P = 0.002). Exercise increased fat oxidation (P = 0.013) and decreased carbohydrate oxidation post-meal (P = 0.022), with concomitantly lower RER (P = 0.005). Energy expenditure rose during exercise (P < 0.001), but no difference occurred postprandially (P = 0.543).</p><p><strong>Conclusions: </strong>Acute exercise prior to a PKU-like meal does not affect postprandial GLP-1 and PYY concentrations compared to control but GDF-15 was increased and RER was reduced, potentially improving appetite regulation.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupoint injection increases the efficacy of vitamin B12 for diabetic neuropathy: a meta-analysis and trial sequential analysis.","authors":"Yunfeng Yu, Tongyi Zhou, Liu Li, Xiu Liu, Yuman Yin, Rong Yu","doi":"10.1038/s41430-025-01631-z","DOIUrl":"https://doi.org/10.1038/s41430-025-01631-z","url":null,"abstract":"<p><p>This study aims to systematically evaluate the efficacy and safety of vitamin B12 acupoint injections compared to other administration routes in treating diabetic neuropathy (DN). We included 20 randomized controlled trials published before March 1, 2024, sourced from eight public databases, involving 1688 participants. Subsequently, we recorded their basic data, investigated their risk of bias, and then carried out a meta-analysis and trial sequential analysis (TSA). The meta-analysis revealed that compared to other administration routes of vitamin B12, acupoint injection significantly improved the clinical effectiveness proportion by 28% (risk ratio [RR] 1.28, 95% confidence interval [CI] 1.22-1.35), peroneal nerve motor nerve conduction velocity (MNCV) by 4.43 m/s (MD 4.43, 95% CI 2.83-6.03), peroneal nerve sensory nerve conduction velocity (SNCV) by 3.82 m/s (MD 3.82, 95% CI 3.23-4.41), median nerve MNCV by 5.48 m/s (MD 5.48, 95% CI 4.71-6.24), and median nerve SNCV by 4.62 m/s (MD 4.62, 95% CI 3.84-5.39) in patients with DN, while having no significant impact on fasting blood glucose (FBG) (MD -0.18, 95% CI -0.44 to 0.08), 2-h postprandial blood glucose (2h-PBG) (MD -0.02, 95% CI -0.36 to 0.33), and the adverse event incidence (RR 1.44, 95% CI 0.44-4.70). TSA indicated that except for FBG, 2h-PBG, and adverse event incidence, the remaining meta-analysis results were conclusive. These findings indicate that compared to other administration routes of vitamin B12, acupoint injection improves neurological function in patients with DN without increasing adverse events and economic burden, suggesting that it may be the optimal administration route for vitamin B12.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of common fats and oils with cardiometabolic health outcomes in the Framingham Offspring cohort.","authors":"Xinyi Zhou, Ioanna Yiannakou, Mengjie Yuan, Martha R Singer, Lynn L Moore","doi":"10.1038/s41430-025-01601-5","DOIUrl":"https://doi.org/10.1038/s41430-025-01601-5","url":null,"abstract":"<p><strong>Background/objectives: </strong>Evidence on the long-term associations between common fats and oils and cardiometabolic health is lacking. We evaluated the associations of butter, margarine, and non-hydrogenated oils with cardiometabolic risk (CMR) and the development of cardiovascular disease (CVD) and type 2 diabetes (T2DM) in the Framingham Offspring cohort.</p><p><strong>Methods/subjects: </strong>We included 2459 subjects (≥30 years) with valid three-day food records. Multivariable Cox proportional hazards models were used to compute hazard ratios for incident CVD and T2DM over ~18 years; analysis of covariance was used to estimate adjusted mean levels of CMR factors (adiposity, insulin resistance, fasting glucose, lipids) over four years associated with baseline intakes of butter, margarine, and non-hydrogenated oils.</p><p><strong>Results: </strong>Higher intakes of butter (>5 vs. 0 g/day) were associated with less insulin resistance (p = 0.0011), higher HDL-C levels (p = 0.0021), lower triglycerides (TG) (p = 0.0032), and lower TG:HDL ratio (p = 0.0052), as well as a 31% lower risk of T2DM (95% CI: 0.49, 0.97). Higher margarine intakes (>7 vs. <2 g/day) were associated with a 29% increased risk of CVD (95% CI:1.02, 1.63) and a 41% increased risk of T2DM (95% CI:1.02, 1.95). Lastly, higher consumption of non-hydrogenated oils (>7 vs. ≤2 g/day) was associated with a 0.6 kg/m² higher BMI and 8 mg/dL higher LDL-C levels.</p><p><strong>Conclusions: </strong>More than one teaspoon (5 g) of butter/day was beneficially associated with several CMR factors and a lower T2DM risk, while margarine was associated with an increased risk of both CVD and T2DM. These findings suggest butter may be a healthier dietary fat source for the benefit of CMR.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}