European Journal of Clinical Nutrition最新文献

{"title":"A 4-week caloric restriction with high volume resistance-training and high-protein diet does not increase fat-free mass sparing but increases strength.","authors":"Samir Nait-Yahia, Mikael F Kanaan, Noémie Beauregard, Merissa Jade Anderton, Andrea Duval, Éric Doucet","doi":"10.1038/s41430-026-01757-8","DOIUrl":"https://doi.org/10.1038/s41430-026-01757-8","url":null,"abstract":"<p><strong>Background: </strong>Athletes employ weight loss protocols to lower fat mass (FM) and maintain fat-free mass (FFM) for performance purposes. High volume resistance-training (HVRT) has been associated with greater increases in FFM than low volume resistance-training (LVRT). However, less is known about the effects of HVRT under caloric restriction (CR). Therefore, it remains unclear whether HVRT could elicit greater retention of FFM and improvements in strength during CR.</p><p><strong>Objectives: </strong>Determine the effects of HVRT and high protein intake on FFM and strength in resistance- trained individuals after a 40% CR.</p><p><strong>Methods: </strong>Sixteen resistance-trained individuals underwent a high-protein (2.3 g/kg body mass (BM)), 4- week 40% CR with a 5-day/week resistance-training intervention. Participants were randomly assigned to LVRT (12 sets/muscle group/week) or HVRT (30 sets/muscle group/week). Pre-post intervention testing included dual energy x-ray absorptiometry, indirect calorimetry, dietary records, resistance-training records, 5RM strength testing, and nitrogen balance.</p><p><strong>Results: </strong>Significant reductions in BM (Δ -4.2 ± 0.5 kg, p < 0.001), FM (Δ -3.7 ± 0.4 kg, p < 0.001), and %FM (Δ -3.5 ± 0.4%, p < 0.001) were observed, but changes were not different between groups. No intervention or group by intervention effects were noted for FFM. HVRT produced greater increases for 5RM testing for chest press (p = 0.005), right leg press (p = 0.003), and left leg press (p < 0.001).</p><p><strong>Conclusion: </strong>HVRT does not seem to further enhance FFM retention during a 40% CR. Albeit, greater increases in strength were noted in HVRT, but mechanisms underlying such improvements remain to be investigated.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between socio-demographic factors and diet patterns among Indian women in a low-income urban setting.","authors":"Sarah H Kehoe, Harsha Chopra, Devi Shivshankaran, Chiara Di Gravio, Sirazul A Sahariah, Meera Gandhi, Barrie M Margetts, Ramesh D Potdar, Caroline H D Fall","doi":"10.1038/s41430-026-01739-w","DOIUrl":"https://doi.org/10.1038/s41430-026-01739-w","url":null,"abstract":"<p><strong>Background/objectives: </strong>Improving the diets of women of reproductive age living in Mumbai slums may benefit their own health and that of their children. Our objective was to identify diet patterns in this population group.</p><p><strong>Subjects/methods: </strong>Participants were married women (n = 6513) aged <40 years enroled in a randomised controlled trial of a food-based intervention. We collected dietary data at the time of enrolment using a 212-item food frequency questionnaire. We used principal component analysis and cluster analysis to identify dietary patterns and explored socio-demographic correlates of the patterns using multivariate linear regression models.</p><p><strong>Results: </strong>We identified 2 interpretable patterns. The first, named the 'Snack, Fruit and Sweet' pattern was characterised by vegetable curry, fried snacks, salad, fruit, sweets and sweetened beverages and explained 9.3% of the variance. Scores on this pattern were independently associated with the women not working versus being employed (0.13, CI: 0.06, 0.19, p < 0.001) and with standard of living index score (0.03, CI: 0.02, 0.04, p < 0.001). The second pattern was named 'Non-vegetarian' and was characterised by meat and biriyani and rice and noodle dishes, with low intakes of lentils, legumes, nuts and seeds. This pattern was associated with being Muslim and was negatively associated with age (-0.02, CI: -0.03, -0.02, p < 0.001) and standard of living index (-0.01, CI: -0.01, 0.00, p < 0.001). It explained 6.7% of the variance.</p><p><strong>Conclusions: </strong>We identified two interpretable patterns that can be used to better understand dietary habits in Mumbai slums. This knowledge can be used to target interventions aimed at improving diet quality in these communities.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: Vitamin D status and response to supplementation in very preterm infants: A prospective cohort study.","authors":"Suphawe Wasuanankun, Prattana Rattanachamnongk, Buranee Yangthara, Sopapan Ngerncham, Ratchada Kitsommart, Punnanee Wutthigate","doi":"10.1038/s41430-026-01759-6","DOIUrl":"https://doi.org/10.1038/s41430-026-01759-6","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between bioimpedance-measured and calf-derived appendicular skeletal muscle mass in amyotrophic lateral sclerosis patients.","authors":"Domenico Azzolino, Aida Zulueta, Rachele Piras, Paola Mariani, Riccardo Sideri, Tiziano Lucchi, Christian Lunetta","doi":"10.1038/s41430-026-01758-7","DOIUrl":"https://doi.org/10.1038/s41430-026-01758-7","url":null,"abstract":"<p><strong>Background: </strong>Over time, amyotrophic lateral sclerosis (ALS) has been considered an accelerated model of sarcopenia. However, muscle mass is rarely assessed in ALS patients. The aim of this study was to explore the agreement between bioelectrical impedance analysis (BIA)-measured and calf circumference (CC)-derived appendicular skeletal muscle mass index (ASMMI) in ALS patients.</p><p><strong>Methods: </strong>Body composition was assessed using anthropometric measures and BIA. Pearson analyses were used to assess correlations and Kappa (κ) statistics were used to evaluate agreement between BIA-measured and CC-derived ASMMI. CC predictive ability was assessed through the area under the receiver operating characteristic curve.</p><p><strong>Results: </strong>A total of 61 ALS patients were included. The CC-ASMM was highly correlated with the BIA-ASMM (r = 0.830, p < 0.001) and CC-ASMMI was moderately correlated with BIA-ASMMI (r = 0.62, p < 0.001). Low CC-derived and BIA-derived ASMMI presented a moderate degree of agreement in the overall sample (k = 0.546, 95% CI 0.325-0.767) and in men (k = 0.432, 95% CI 0.056-0.809), while a substantial agreement was observed in women (k = 0.613, 95% CI 0.344-0.883). The optimal cut-off values for CC in identifying low ASMMI from the ROC analysis, were 34 cm for both sexes with an area under the curve (AUC) of 0.818 for men (sensitivity 80%, specificity 78.3%) and of 0.841 (sensitivity 83.3%, specificity 72.7%) for women.</p><p><strong>Conclusion: </strong>Our preliminary study showed a good predictive ability of the CC, an anthropometric parameter significantly associated with sarcopenia, in reflecting the ASMM. The best performance was found for a CC cut-off point of ≤34 cm in both sexes.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancies between caliper and portable A-mode ultrasound estimates of subcutaneous fat in older adults.","authors":"Lara Vilar Fernandes, Gabriela Benatti de Oliveira, Rui Valdiviesso, Teresa F Amaral, Ligiana Pires Corona","doi":"10.1038/s41430-026-01756-9","DOIUrl":"https://doi.org/10.1038/s41430-026-01756-9","url":null,"abstract":"<p><p>It has been proposed that subcutaneous fat thickness measured by ultrasound corresponds to half of the skinfold thickness measured with calipers at the same anatomical site. This study compared portable A-mode ultrasound and caliper skinfold assessments in older adults. In a cross-sectional sample of 146 participants, fat thickness was measured at the biceps brachii, triceps brachii, subscapular, and suprailiac sites using a BodyMetrix® BX-2000 ultrasound device and a LipoWise PRO digital caliper. Agreement between methods varied markedly by site: Lin's concordance correlation coefficients were 0.21 (triceps), 0.02 (subscapular), and 0.33 (biceps, suprailiac), indicating poor to moderate concordance. The Bradley-Blackwood test showed differences between methods (p < 0.001). Skinfold/ultrasound mean ratios were 1.50 (triceps), 1.20 (biceps), 1.50 (suprailiac), and 2.90 (subscapular). Caliper skinfold measurements consistently overestimate subcutaneous fat thickness versus ultrasound, especially at the subscapular site, limiting interchangeability and potentially compromising clinical assessment accuracy in older adult populations.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A series of N-of-1 dietary intervention studies with whole-grain foods and nuts reveals individual predictors of blood pressure and heart rate.","authors":"Tilly I T Potter, Fieke Pepping, Anne J Wanders, Elizabeth H Zandstra, Peter L Zock, Rikard Landberg, Rute Vieira, Baukje de Roos","doi":"10.1038/s41430-026-01740-3","DOIUrl":"https://doi.org/10.1038/s41430-026-01740-3","url":null,"abstract":"<p><strong>Background/objectives: </strong>To determine predictors of systolic and diastolic blood pressure (SBP/DBP), of heart rate, and of whole-grains and nuts consumption, on an individual level, using a series of N-of-1 studies.</p><p><strong>Methods: </strong>Participants were enrolled in individual 24-wk N-of-1 studies, consisting of 8-wk observation, intervention, and follow-up periods. Participants completed personalized morning and evening questionnaires and took their own blood pressure daily. During the intervention period, participants received 3-4 portions of whole-grains and a portion of nuts daily. Fasted blood samples were collected every 4 weeks for analysis of lipids and plasma alkylresorcinol concentrations. Dynamic regression modeling was used to determine factors associated with changes in blood pressure, heart rate, and compliance with the intervention.</p><p><strong>Results: </strong>12 participants completed their study, with 11 collecting enough data to permit analysis. Dynamic regression modeling identified variables significantly affecting individual blood pressure, heart rate, and consumption of whole-grains and nuts, including sleep quality, weekday, motivation to eat well, alcohol consumption, day of menstrual cycle, outside temperature, and physical activity. Consumption of whole-grains and nuts was associated with a significant (p < 0.01) decrease in SBP for one participant, a significant (p < 0.05) decrease in DBP for two participants, and a significant (p < 0.01) lowering in heart rate for five participants.</p><p><strong>Conclusions: </strong>The N-of-1 studies uniquely identified individual-level factors that were associated with changes in blood pressure and heart rate, and with compliance to consumption of whole-grains and nuts. N-of-1 studies are imperative to better understand heterogeneity of response and to develop more targeted, personalized and acceptable dietary advice.</p><p><strong>Trial registration: </strong>https://clinicaltrials.gov/study/NCT04326686 . First registered 20 March 2020.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the predictive value of PNI and GNRI for all-cause mortality rates of elderly patients in cardiac care unit and cardiovascular intensive care unit.","authors":"Wanlu Zhou, Jingjia Yu, Min Zheng, Ruizheng Shi","doi":"10.1038/s41430-026-01741-2","DOIUrl":"https://doi.org/10.1038/s41430-026-01741-2","url":null,"abstract":"<p><strong>Background: </strong>The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) are reliable alternative biomarkers of nutrition. However, the relationship between nutritional indicators and mortality of elderly patients in the cardiac care unit (CCU) and cardiovascular intensive care unit (CVICU) remains unknown.</p><p><strong>Methods: </strong>This retrospective observational study analyzed data from 811 elderly patients in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The primary outcome was 360-day all-cause mortality. PNI and GNRI were evaluated using restricted cubic spline (RCS), Cox proportional hazards model, Kaplan-Meier curve, and subgroup analyses. Predictive models were developed using machine learning (ML) algorithms, and the predictive values of feature variables were assessed using the SHapley Additive exPlanation (SHAP) algorithm.</p><p><strong>Results: </strong>RCS and Cox models showed that higher nutritional indices were associated with lower mortality risk. Kaplan-Meier curves further confirmed higher mortality in patients with lower indices. Four ML algorithms were constructed. Among these, the logistic regression (LR) algorithm demonstrated superior performance compared to the others, with PNI and GNRI identified as the key predictors. Subgroup analyses showed consistent PNI and GNRI effects across congestive heart failure (CHF), myocardial infarction (MI), acute kidney injury (AKI), and type 2 diabetes mellitus (T2DM), with no significant interactions.</p><p><strong>Conclusion: </strong>Nutritional indices were significantly associated with the mortality risk of elderly patients in CCU and CVICU.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct dietary patterns across type 2 diabetes subtypes: Insights from the SMART2D cohort.","authors":"Mei Chung Moh, Tsz Kiu Kwan, Jun Shi Lai, Marjorelee T Colega, Chalani U Ubeynarayana, Huili Zheng, Jian-Jun Liu, Keven Ang, Sylvia Liu, Wern Ee Tang, Ziliang Lim, Tavintharan Subramaniam, Chee Fang Sum, Mary Foong-Fong Chong, Su Chi Lim","doi":"10.1038/s41430-026-01753-y","DOIUrl":"https://doi.org/10.1038/s41430-026-01753-y","url":null,"abstract":"<p><strong>Background/objectives: </strong>We previously identified three validated clinical subtypes of type 2 diabetes (T2D) in a multi-ethnic Southeast Asian cohort, but their dietary patterns remained uncharacterised. This cross-sectional analysis explored whether dietary patterns differ across T2D subtypes and examined subtype-specific associations with diabetes-related comorbidities.</p><p><strong>Subjects/methods: </strong>Dietary patterns were derived using factor analysis of 46 food groups from 1007 T2D adults (age:61 ± 11 years, 52.7% male) who completed a 125-item food frequency questionnaire. T2D subtypes including mild age-related diabetes with insulin insufficiency (MARD-II), mild obesity-related diabetes (MOD), and severe insulin-resistant diabetes with relative insulin insufficiency (SIRD-RII) were classified using the nearest centroid approach. Each participant's predominant dietary pattern was defined by their highest factor score. Associations between T2D subtypes and dietary pattern scores, and between predominant dietary patterns and comorbidities within each subtype, were assessed using multivariable regression analysis.</p><p><strong>Results: </strong>Three patterns were identified: meat, fast food & eat-out; sugar-laden food & drinks; and plant-based & dairy. Among MARD-II, 40.0% had a predominant plant-based & dairy pattern, whereas both MOD and SIRD-RII had predominant sugar-laden food & drinks (~38%), followed by meat, fast food & eat-out (~31%) patterns. Compared with MARD-II, MOD and SIRD-RII were positively associated with meat, fast food & eat-out pattern and inversely with plant-based & dairy pattern (all P < 0.001). Predominant sugar-laden food & drinks and meat, fast food & eat-out patterns were differentially associated with comorbidities, particularly in MOD and SIRD-RII.</p><p><strong>Conclusions: </strong>Our findings suggest distinct dietary intake/patterns and subtype-specific associations with comorbidities in multi-ethnic Southeast Asians with T2D.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimethylamine N-oxide (TMAO) as a prognostic marker among patients at nutritional risk. A secondary analysis of the randomized clinical trial EFFORT.","authors":"Adina Stern, Carla Wunderle, Pascal Tribolet, Peter J Neyer, Luca Bernasconi, Zeno Stanga, Beat Mueller, Philipp Schuetz","doi":"10.1038/s41430-026-01750-1","DOIUrl":"https://doi.org/10.1038/s41430-026-01750-1","url":null,"abstract":"<p><strong>Background: </strong>Trimethylamine N-oxide (TMAO), a metabolite produced by the gut microbiota, is highly influenced by dietary factors and is linked to negative health outcomes including all-cause mortality and cardiovascular events. We evaluated the prognostic value of TMAO among hospitalized patients at nutritional risk participating in the Effect of early nutritional support on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial (EFFORT) regarding clinical outcomes and response to nutritional support.</p><p><strong>Clinical trial registration: </strong>clinicaltrials.gov as NCT02517476 (registered 7 August 2015) METHODS: This secondary analysis is based on the randomized-controlled EFFORT trial, which compared individualized nutritional therapy with usual care in medical inpatients at nutritional risk. We studied the association of admission TMAO concentrations with all-cause mortality after 180 days (primary endpoint) and major adverse cardiovascular events (MACE) using quartile-based regression analysis.</p><p><strong>Results: </strong>Among 218 patients with available TMAO measurements, those in higher quartiles showed an increased all-cause mortality compared to the lowest quartile after 180 days (adjusted HR 1.92 95% CI 1.03-3.56, p = 0.04) and 5 years (adjusted HR 2.01 95% CI 1.23-3.31, p = 0.006). A similar trend was observed for MACE. We found no significant associations between dietary factors or nutritional history and admission TMAO levels, nor was TMAO predictive regarding the response to nutritional therapy.</p><p><strong>Conclusion: </strong>The risk of mortality over six months nearly doubled in patients at risk of malnutrition with elevated baseline TMAO levels. Additional research is needed to determine if dietary interventions can successfully modulate TMAO levels and, in turn, improve clinical outcomes.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference values for bioelectrical impedance-derived phase angle: a cross-sectional study of 5,049 healthy individuals from Colombia.","authors":"Frank Carrera-Gil, Robinson Ramírez-Vélez, Gildardo Uribe-Gil","doi":"10.1038/s41430-026-01744-z","DOIUrl":"https://doi.org/10.1038/s41430-026-01744-z","url":null,"abstract":"<p><strong>Background and aims: </strong>Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is a noninvasive indicator of cellular integrity and body cell mass. PhA varies with age, sex, and population background; however, reference data from Latin American populations remain limited. This study therefore aimed to establish age- and sex-specific PhA reference values and percentile curves in a healthy Colombian population.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 5,049 individuals (3,113 females) aged 10-94 years. PhA was calculated directly from body resistance and reactance obtained from BIA. Smoothed centile curves and tables for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated using the Lambda-Mu-Sigma (LMS) method to develop sex- and age-specific norms.</p><p><strong>Results: </strong>PhA followed a non-linear pattern with age, increasing during adolescence and early adulthood, peaking around midlife (40-49 years), and declining thereafter. Males consistently exhibited higher PhA values than females across all age groups. Sex-specific percentile curves (P3-P97) were generated, illustrating the distribution of the PhA by age group and providing normative reference values for clinical and research applications.</p><p><strong>Conclusion: </strong>This study provides the first age- and sex-specific phase angle reference values for a healthy Colombian population, addressing the lack of normative standards in Latin America. These population-specific curves offer clinically relevant benchmarks that may improve the assessment of cellular health and nutritional status in diverse settings.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}