Environmental Health Perspectives最新文献

{"title":"Hair Straightener Use in Relation to Prevalent and Incident Fibroids in the Sister Study with a Focus on Black Women.","authors":"Kemi Ogunsina, Katie M O'Brien, Alexandra J White, Che-Jung Chang, Symielle A Gaston, Chandra L Jackson, Dale P Sandler","doi":"10.1289/EHP14493","DOIUrl":"10.1289/EHP14493","url":null,"abstract":"<p><strong>Background: </strong>Uterine fibroids disproportionately affect Black women, and exposure to chemicals from hair relaxers or straighteners (\"straighteners\") may contribute to fibroid development.</p><p><strong>Objectives: </strong>We examined the association between straightener use and prevalent young-onset uterine fibroids (diagnosed before age 36 y), as well as incident fibroids (diagnosed age 36-60 y), with a focus on Black women. We also examined differences in associations across birth cohorts as proxies for formulation changes.</p><p><strong>Methods: </strong>Data from 4,162 Black women in the Sister Study, a prospective cohort of women 35-74 y of age (enrolled 2003-2009), were analyzed. We used logistic regression to estimate odds ratios (ORs) for the association of straightener use at 10-13 y of age and self-reported young-onset fibroids. We used Cox regression to assess hazard ratios (HRs) for straightener use (age 10-13 y and in 12 months before enrollment) and incident fibroids among 779 premenopausal Black women. Similar analyses were conducted in 40,782 non-Hispanic White women.</p><p><strong>Results: </strong>Over 70% of Black women used straighteners. In comparison with no use, any [<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.15</mn></mrow></math>; 95% confidence interval (CI): 0.96, 1.36] and frequent use (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.18</mn></mrow></math>; 95% CI: 0.99, 1.42) of straighteners at 10-13 y of age were associated with young-onset fibroids. This association was most apparent among those born between 1928 and 1945 (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.78</mn></mrow></math>; 95% CI: 1.15, 2.74) and 1965-1974 (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.64</mn></mrow></math>; 95% CI: 0.82, 3.29). Fibroid incidence from 36 to 60 y of age was modestly associated with use of straighteners at 10-13 y of age [hazard ratio <math><mrow><mo>(</mo><mtext>HR</mtext><mo>)</mo><mo>=</mo><mn>1.14</mn></mrow></math>; 95% CI: 0.81, 1.63] and in the 12 months prior to enrollment (<math><mrow><mtext>HR</mtext><mo>=</mo><mn>1.32</mn></mrow></math>; 95% CI: 0.88, 2.00). Among non-Hispanic White women, straightener use at 10-13 y of age was similarly associated with young-onset fibroids (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.23</mn></mrow></math>; 95% CI: 1.03, 1.47) despite lower use (<math><mrow><mo>≤</mo><mn>5</mn><mo>%</mo></mrow></math>) of straighteners. Sensitivity analyses indicated a potential for bias due to fibroid misclassification, with an overestimation of the effect likely if nulliparous women or women from households with lower education reported their fibroid status less accurately.</p><p><strong>Discussion: </strong>Hair straightener use may be positively associated with fibroid risk. https://doi.org/10.1289/EHP14493.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17004"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to Drinking Water Trihalomethanes and Risk of Cancer: A Systematic Review of the Epidemiologic Evidence and Dose-Response Meta-Analysis.","authors":"Emilie Helte, Fredrik Söderlund, Melle Säve-Söderbergh, Susanna C Larsson, Agneta Åkesson","doi":"10.1289/EHP14505","DOIUrl":"10.1289/EHP14505","url":null,"abstract":"<p><strong>Background: </strong>Chlorination is a widespread method for drinking water disinfection that has the drawback of introducing potentially carcinogenic chemical by-products to drinking water.</p><p><strong>Objective: </strong>We systematically evaluated the epidemiologic evidence of exposure to trihalomethane (THM) disinfection by-products and risk of cancer.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of epidemiologic studies that assessed the association of exposure to residential concentrations of THMs with risk of cancer in adults. A protocol was preregistered in PROSPERO (CRD42023435491). PubMed, Embase, Web of Science, and Cochrane were searched for publications up to April 2024. Study selection and risk of bias appraisal using the National Toxicology Program Office of Health Assessment and Translation (NTP OHAT) tool was done in duplicate. Summary risk estimates were assessed using random effects meta-analysis and one-stage dose-response meta-analysis.</p><p><strong>Results: </strong>The literature search resulted in 2,022 records, of which 29 publications assessing 14 different cancers were eligible for inclusion. Summary relative risks (RRs) were estimated for bladder cancer and colorectal cancer based on 5,860 and 9,262 cases and 84,371 and 90,272 participants, respectively. The summary RR of bladder cancer for the highest exposed compared with the lowest was 1.33 (95% CI: 1.04, 1.71), and in the dose-response analysis, RRs were statistically significant above THM concentrations of <math><mrow><mn>41</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mi>L</mi></mrow></math>. For colorectal cancer, the summary RR was 1.15 (95% CI: 1.07, 1.24).</p><p><strong>Conclusion: </strong>According to the World Cancer Research Fund criteria, we found limited-suggestive evidence that THM in drinking water increases the risk of bladder and colorectal cancer at levels below current regulatory limits in the US and EU, indicating that these fail to protect against cancer in the general population. https://doi.org/10.1289/EHP14505.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"16001"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Multifaceted Intervention (TEMP) for Prevention of Occupational Heat-Related Illness among Outdoor Workers in the Power Grid Industry: A Cluster Randomized Controlled Trial.","authors":"Ranyi Ding, Yutong Wang, Yuelin Yu, Xianglong Meng, Quanquan Gong, Yuchuan Tang, Jinhao Wang, Xianlin Mu, Huiping Li, Huziwei Zhou, Shengfeng Wang, Ping Liu","doi":"10.1289/EHP14172","DOIUrl":"10.1289/EHP14172","url":null,"abstract":"<p><strong>Background: </strong>Occupational heat-related illness (OHI) is a health threat to workers that can be fatal in severe cases. Effective and feasible measures are urgently needed to prevent OHI.</p><p><strong>Objectives: </strong>We evaluated the effectiveness of a multifaceted intervention, TEMP, in reducing the OHI risk among outdoor workers in the power grid industry.</p><p><strong>Methods: </strong>A cluster randomized controlled trial was conducted with power grid outdoor workers in Southern China from 4 July 2022 to 28 August 2022. Work groups were randomly allocated (1:1) to the intervention or control groups. The multifaceted intervention TEMP comprised mobile application (app)-based education training (T), personal protective equipment [PPE (E)], OHI risk monitoring (M), and educational posters (P). Four follow-ups were conducted every 2 wk after the trial began. The primary outcome was the OHI incidence, and the secondary outcome was PPE usage. The app usage was considered as the compliance of intervention in the intervention group. The primary analysis used was intention-to-treat analysis. Multilevel analyses using random effects logistic regression models were performed to compare the odds of OHI between the two groups, adjusted for individual-level (education and work position) and work-related (including water intake when feeling thirsty, cooling measures, and poor sleep before work) covariates.</p><p><strong>Results: </strong>Of 528 participants, 422 (79.92%) were males, and the <math><mrow><mtext>mean</mtext><mo>±</mo><mtext>SD</mtext></mrow></math> age was <math><mrow><mn>36.36</mn><mo>±</mo><mn>8.18</mn></mrow></math> y. The primary outcome, OHI incidence, was 1.80% in the intervention group and 4.82% in the control group at the end of the whole follow-up. OHI mainly occurred between 1100 and 1500 hours, with nausea, significantly increased heart rate, and oliguria being the top three reported OHI symptoms. Compared with the control group, the adjusted odds ratios between the intervention group and control group were 0.73 [95% confidence interval (CI): 0.30, 1.76] in the first follow-up wave, with 0.38 (95% CI: 0.15, 0.97), 0.29 (95% CI: 0.08, 1.05), and 0.39 (95% CI: 0.13, 1.19) in the following three follow-up waves, respectively. The intervention also significantly improved PPE usage in the intervention group.</p><p><strong>Discussions: </strong>This multifaceted intervention reduced the OHI risk among outdoor workers in the power grid industry. However, further research is needed to design a more flexible intervention strategy and evaluate its effectiveness in a larger population. https://doi.org/10.1289/EHP14172.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17001"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Critical Needs for Advancing Beauty Justice.","authors":"Ami R Zota, Eva L Siegel","doi":"10.1289/EHP16497","DOIUrl":"10.1289/EHP16497","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"11302"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic.","authors":"Kiran Makhani, Xiuhui Yang, France Dierick, Nivetha Subramaniam, Natascha Gagnon, Talin Ebrahimian, Stephanie Lehoux, Hao Wu, Jun Ding, Koren K Mann","doi":"10.1289/EHP14285","DOIUrl":"10.1289/EHP14285","url":null,"abstract":"<p><strong>Background: </strong>Millions worldwide are exposed to elevated levels of arsenic that significantly increase their risk of developing atherosclerosis, a pathology primarily driven by immune cells. While the impact of arsenic on immune cell populations in atherosclerotic plaques has been broadly characterized, cellular heterogeneity is a substantial barrier to in-depth examinations of the cellular dynamics for varying immune cell populations.</p><p><strong>Objectives: </strong>This study aimed to conduct single-cell multi-omics profiling of atherosclerotic plaques in apolipoprotein E knockout (<i>ApoE</i>^-/-) mice to elucidate transcriptomic and epigenetic changes in immune cells induced by arsenic exposure.</p><p><strong>Methods: </strong>The <i>ApoE</i>^-/- mice were fed a high-fat diet and were exposed to either <math><mrow><mn>200</mn><mtext> ppb</mtext></mrow></math> arsenic in drinking water or a tap water control, and single-cell multi-omics profiling was performed on atherosclerotic plaque-resident immune cells. Transcriptomic and epigenetic changes in immune cells were analyzed within the same cell to understand the effects of arsenic exposure.</p><p><strong>Results: </strong>Our data revealed that the transcriptional profile of macrophages from arsenic-exposed mice were significantly different from that of control mice and that differences were subtype specific and associated with cell-cell interaction and cell fates. Additionally, our data suggest that differences in arsenic-mediated changes in chromosome accessibility in arsenic-exposed mice were statistically more likely to be due to factors other than random variation compared to their effects on the transcriptome, revealing markers of arsenic exposure and potential targets for intervention.</p><p><strong>Discussion: </strong>These findings in mice provide insights into how arsenic exposure impacts immune cell types in atherosclerosis, highlighting the importance of considering cellular heterogeneity in studying such effects. The identification of subtype-specific differences and potential intervention targets underscores the significance of understanding the molecular mechanisms underlying arsenic-induced atherosclerosis. Further research is warranted to validate these findings and explore therapeutic interventions targeting immune cell dysfunction in arsenic-exposed individuals. https://doi.org/10.1289/EHP14285.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17007"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valley Fever: Fine Mineral Dust Modeling Points to High-Risk Regions and Seasons in California.","authors":"Silke Schmidt","doi":"10.1289/EHP16213","DOIUrl":"10.1289/EHP16213","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"14002"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Drinking Water Disinfection By-Products and Cancer-A Historical Perspective.","authors":"Cristina M Villanueva","doi":"10.1289/EHP16443","DOIUrl":"10.1289/EHP16443","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"11303"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When It Rains It Pours: <i>Campylobacter</i> Infection Rates after Rain on Wet and Dry Soils.","authors":"Charles Schmidt","doi":"10.1289/EHP16432","DOIUrl":"10.1289/EHP16432","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"14001"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Carbon Footprint of Hospital Services and Care Pathways: A State-of-the-Science Review.","authors":"Lisanne H J A Kouwenberg,Eva S Cohen,Wouter J K Hehenkamp,Lynn E Snijder,Jasper M Kampman,Burcu Küçükkeles,Arno Kourula,Marijn H C Meijers,Eline S Smit,Nicolaas H Sperna Weiland,Dionne S Kringos","doi":"10.1289/ehp14754","DOIUrl":"https://doi.org/10.1289/ehp14754","url":null,"abstract":"BACKGROUNDClimate change is the 21st century's biggest global health threat, endangering health care systems worldwide. Health care systems, and hospital care in particular, are also major contributors to greenhouse gas emissions.OBJECTIVESThis study used a systematic search and screening process to review the carbon footprint of hospital services and care pathways, exploring key contributing factors and outlining the rationale for chosen services and care pathways in the studies.METHODSThis state-of-the-science review searched the MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), GreenFILE (EBSCOhost), Web of Science, Scopus, and the HealthcareLCA databases for literature published between 1 January 2000 and 1 January 2024. Gray literature was considered up to 1 January 2024. Inclusion criteria comprised original research reporting on the carbon footprint of hospital services or care pathways. Quality of evidence was assessed according to the guidelines for critical review of product life cycle assessment (LCA). PROSPERO registration number: CRD42023398527.RESULTSOf 5,415 records, 76 studies were included, encompassing 151 hospital services and care pathways across multiple medical specialties. Reported carbon footprints varied widely, from 0.01kg carbon dioxide (CO2) equivalents (kgCO2e) for an hour of intravenously administered anesthesia to 10,200 kgCO2e for a year of hemodialysis treatment. Travel, facilities, and consumables were key contributors to carbon footprints, whereas waste disposal had a smaller contribution. Relative importance of carbon hotspots differed per service, pathway, medical specialty, and setting. Studies employed diverse methodologies, including different LCA techniques, functional units, and system boundaries. A quarter of the studies lacked sufficient quality.DISCUSSIONHospital services and care pathways have a large climate impact. Quantifying the carbon footprint and identifying hotspots enables targeted and prioritized mitigation efforts. Even for similar services, the carbon footprint varies considerably between settings, underscoring the necessity of localized studies. The emerging field of health care sustainability research faces substantial methodological heterogeneity, compromising the validity and reproducibility of study results. This review informs future carbon footprint studies by highlighting understudied areas in hospital care and providing guidance for selecting specific services and pathways. https://doi.org/10.1289/EHP14754.","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"62 1","pages":"126002"},"PeriodicalIF":10.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Accelerating Action toward Carbon-Neutral Hospital Care.","authors":"Tim Stobernack,Emma J Kooistra,Hugo R W Touw","doi":"10.1289/ehp16623","DOIUrl":"https://doi.org/10.1289/ehp16623","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"15 1","pages":"121301"},"PeriodicalIF":10.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}