Environmental Health Perspectives最新文献

{"title":"Invited Perspective: Critical Needs for Advancing Beauty Justice.","authors":"Ami R Zota, Eva L Siegel","doi":"10.1289/EHP16497","DOIUrl":"10.1289/EHP16497","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"11302"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Variation in the Association between Extreme Heat Events and Warm Season Pediatric Acute Care Utilization: A Small-Area Assessment of Multiple Health Conditions and Environmental Justice Implications in California (2005-2019).","authors":"Allan Ndovu, Chen Chen, Lara Schwarz, Emma Lasky, Sheri D Weiser, Tarik Benmarhnia","doi":"10.1289/EHP14236","DOIUrl":"10.1289/EHP14236","url":null,"abstract":"<p><strong>Background: </strong>The increasing frequency and severity of extreme heat events due to climate change present unique risks to children and adolescents. There is a lack of evidence regarding how heat's impacts on pediatric patients vary spatially and how structural and sociodemographic factors drive this heterogeneity.</p><p><strong>Objectives: </strong>We examined the association between extreme heat events and pediatric acute care utilization in California for 19 distinct health conditions. We then assessed how extreme heat's consequences varied at the ZIP code level and identified environmental justice metrics that modulated children's vulnerability to extreme heat.</p><p><strong>Methods: </strong>This study analyzed 7.2 million unscheduled hospitalizations and emergency department visits for children <math><mrow><mo><</mo><mn>19</mn></mrow></math> years old in California between May and September from 2005 to 2019. We first utilized a time-stratified case-crossover design to generate statewide estimates for the association between extreme heat events and care utilization. We then implemented a within-community matched design coupled with a Bayesian hierarchical model to generate spatially varying effect estimates. Finally, we conducted a random effects meta-regression to examine how community-level characteristics modified heat's impacts across ZIP codes.</p><p><strong>Results: </strong>Extreme heat events were associated with substantial increases in acute care utilization for all causes [odds ratio <math><mrow><mo>(</mo><mtext>OR</mtext><mo>)</mo><mo>=</mo><mn>1.03</mn></mrow></math>; 95% confidence interval (CI): 1.03, 1.04] and were attributable for over 30,000 excess acute care utilizations during the study period. Extreme heat events were also associated with increases in heat-related illness (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.53</mn></mrow></math>; 95% CI: 1.49, 1.58); endocrine, nutritional, and metabolic disorders (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.13</mn></mrow></math>; 95% CI: 1.1, 1.16); other signs and symptoms (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.07</mn></mrow></math>; 95% CI: 1.06, 1.08); and injury and poisoning (<math><mrow><mtext>OR</mtext><mo>=</mo><mn>1.07</mn></mrow></math>; 95% CI: 1.05, 1.08). There was substantial spatial heterogeneity in extreme heat events effects, especially in coastal metropolitan areas. Communities with lower incomes and education levels, less access to insurance and air conditioning, and higher percentages of Black, Hispanic, and Pacific Islander residents were most vulnerable during extreme heat events.</p><p><strong>Conclusions: </strong>Extreme heat events in California are associated with increased pediatric care utilization. There is significant variation in heat's consequences, and historically disadvantaged and under-resourced communities are most impacted. These findings suggest that interventions designed to improve heat resilience should be tar","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17010"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic.","authors":"Kiran Makhani, Xiuhui Yang, France Dierick, Nivetha Subramaniam, Natascha Gagnon, Talin Ebrahimian, Stephanie Lehoux, Hao Wu, Jun Ding, Koren K Mann","doi":"10.1289/EHP14285","DOIUrl":"10.1289/EHP14285","url":null,"abstract":"<p><strong>Background: </strong>Millions worldwide are exposed to elevated levels of arsenic that significantly increase their risk of developing atherosclerosis, a pathology primarily driven by immune cells. While the impact of arsenic on immune cell populations in atherosclerotic plaques has been broadly characterized, cellular heterogeneity is a substantial barrier to in-depth examinations of the cellular dynamics for varying immune cell populations.</p><p><strong>Objectives: </strong>This study aimed to conduct single-cell multi-omics profiling of atherosclerotic plaques in apolipoprotein E knockout (<i>ApoE</i>^-/-) mice to elucidate transcriptomic and epigenetic changes in immune cells induced by arsenic exposure.</p><p><strong>Methods: </strong>The <i>ApoE</i>^-/- mice were fed a high-fat diet and were exposed to either <math><mrow><mn>200</mn><mtext> ppb</mtext></mrow></math> arsenic in drinking water or a tap water control, and single-cell multi-omics profiling was performed on atherosclerotic plaque-resident immune cells. Transcriptomic and epigenetic changes in immune cells were analyzed within the same cell to understand the effects of arsenic exposure.</p><p><strong>Results: </strong>Our data revealed that the transcriptional profile of macrophages from arsenic-exposed mice were significantly different from that of control mice and that differences were subtype specific and associated with cell-cell interaction and cell fates. Additionally, our data suggest that differences in arsenic-mediated changes in chromosome accessibility in arsenic-exposed mice were statistically more likely to be due to factors other than random variation compared to their effects on the transcriptome, revealing markers of arsenic exposure and potential targets for intervention.</p><p><strong>Discussion: </strong>These findings in mice provide insights into how arsenic exposure impacts immune cell types in atherosclerosis, highlighting the importance of considering cellular heterogeneity in studying such effects. The identification of subtype-specific differences and potential intervention targets underscores the significance of understanding the molecular mechanisms underlying arsenic-induced atherosclerosis. Further research is warranted to validate these findings and explore therapeutic interventions targeting immune cell dysfunction in arsenic-exposed individuals. https://doi.org/10.1289/EHP14285.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17007"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Drinking Water Disinfection By-Products and Cancer-A Historical Perspective.","authors":"Cristina M Villanueva","doi":"10.1289/EHP16443","DOIUrl":"10.1289/EHP16443","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"11303"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valley Fever: Fine Mineral Dust Modeling Points to High-Risk Regions and Seasons in California.","authors":"Silke Schmidt","doi":"10.1289/EHP16213","DOIUrl":"10.1289/EHP16213","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"14002"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Maternal BPA Exposure during Pregnancy on Obesity in Male Offspring: A Mechanistic Mouse Study of Adipose-Derived Exosomal miRNA.","authors":"Zhenyao Huang, Rui Niu, Qiaoqiao Xu, Rui Zhang, Weiyue Hu, Yufeng Qin, Xinru Wang, Qiujin Xu, Yankai Xia, Yun Fan, Chuncheng Lu","doi":"10.1289/EHP14888","DOIUrl":"10.1289/EHP14888","url":null,"abstract":"<p><strong>Background: </strong>The widespread use of bisphenol A (BPA) has led to universal exposure among the population, raising concerns about its health effects. Epidemiological studies have linked environmentally relevant levels of BPA exposure to obesity.</p><p><strong>Objectives: </strong>We aimed to uncover the complex mechanisms by which oral exposure during pregnancy with BPA affects the offspring.</p><p><strong>Methods: </strong>We conducted a two-stage mouse study. In stage 1, we gavaged dams with BPA at 0.05, 0.5, and <math><mrow><mn>5</mn><mspace></mspace><mi>mg</mi><mo>/</mo><mi>kg</mi><mtext> per day</mtext></mrow></math> during pregnancy, and we tracked the offspring's weight and diet to 12 wk of age. In stage 2, exosomes from BPA-exposed dams and offspring were injected into pregnant mice and 3-wk-old males, respectively, and the mice were observed up to 12 wk. We then sequenced exosomal microRNAs (miRNAs) in male offspring whose dams had been exposed to BPA during pregnancy and checked their expression in adipose, liver, and serum samples at weeks 3, 6, 9, and 12. Finally, we explored the functions of exosomes and exosomal miRNAs secreted by adipose-derived mesenchymal stem cells, and we investigated whether the exosomes and miRNAs they secreted could affect glucose uptake, triglyceride synthesis, and the expression of genes related to glucose and lipid metabolism in alpha mouse liver 12 cells.</p><p><strong>Results: </strong>Gavage of <math><mrow><mn>0.05</mn><mspace></mspace><mi>mg</mi><mo>/</mo><mi>kg</mi><mtext> per day</mtext></mrow></math> of BPA during pregnancy in dams led to obesity in male offspring mice, and injection of exosomes from male offspring with BPA exposure during pregnancy also induced similar outcomes in the next generation of male pups. Exosomal miRNA sequencing identified differentially expressed miRNAs associated with BPA-induced obesity in male offspring, revealing sustained high expression of miRNAs in adipose tissue and a gradual increase in the liver and serum over time. Further mechanistic studies showed that exosomes derived from BPA-treated adipose-derived stem cells reduced the expression of peroxisome proliferator-activated receptor-gamma and fibroblast growth factor 21, leading to impaired insulin signaling and lipid metabolism in hepatocytes. Overexpression of miR-124-3p in hepatocytes mimicked these effects; in contrast, knockdown of miR-124-3p or inhibition of exosome secretion reversed them.</p><p><strong>Discussion: </strong>The present study corroborates the regulatory function of adipose-derived exosomal miRNAs in obesity in male offspring mice resulting from BPA exposure during pregnancy. Exosomal miRNA may be a key and novel molecular biomarker in the adverse effects of chemical exposure during pregnancy. https://doi.org/10.1289/EHP14888.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17011"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When It Rains It Pours: <i>Campylobacter</i> Infection Rates after Rain on Wet and Dry Soils.","authors":"Charles Schmidt","doi":"10.1289/EHP16432","DOIUrl":"10.1289/EHP16432","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"14001"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Carbon Footprint of Hospital Services and Care Pathways: A State-of-the-Science Review.","authors":"Lisanne H J A Kouwenberg,Eva S Cohen,Wouter J K Hehenkamp,Lynn E Snijder,Jasper M Kampman,Burcu Küçükkeles,Arno Kourula,Marijn H C Meijers,Eline S Smit,Nicolaas H Sperna Weiland,Dionne S Kringos","doi":"10.1289/ehp14754","DOIUrl":"https://doi.org/10.1289/ehp14754","url":null,"abstract":"BACKGROUNDClimate change is the 21st century's biggest global health threat, endangering health care systems worldwide. Health care systems, and hospital care in particular, are also major contributors to greenhouse gas emissions.OBJECTIVESThis study used a systematic search and screening process to review the carbon footprint of hospital services and care pathways, exploring key contributing factors and outlining the rationale for chosen services and care pathways in the studies.METHODSThis state-of-the-science review searched the MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), GreenFILE (EBSCOhost), Web of Science, Scopus, and the HealthcareLCA databases for literature published between 1 January 2000 and 1 January 2024. Gray literature was considered up to 1 January 2024. Inclusion criteria comprised original research reporting on the carbon footprint of hospital services or care pathways. Quality of evidence was assessed according to the guidelines for critical review of product life cycle assessment (LCA). PROSPERO registration number: CRD42023398527.RESULTSOf 5,415 records, 76 studies were included, encompassing 151 hospital services and care pathways across multiple medical specialties. Reported carbon footprints varied widely, from 0.01kg carbon dioxide (CO2) equivalents (kgCO2e) for an hour of intravenously administered anesthesia to 10,200 kgCO2e for a year of hemodialysis treatment. Travel, facilities, and consumables were key contributors to carbon footprints, whereas waste disposal had a smaller contribution. Relative importance of carbon hotspots differed per service, pathway, medical specialty, and setting. Studies employed diverse methodologies, including different LCA techniques, functional units, and system boundaries. A quarter of the studies lacked sufficient quality.DISCUSSIONHospital services and care pathways have a large climate impact. Quantifying the carbon footprint and identifying hotspots enables targeted and prioritized mitigation efforts. Even for similar services, the carbon footprint varies considerably between settings, underscoring the necessity of localized studies. The emerging field of health care sustainability research faces substantial methodological heterogeneity, compromising the validity and reproducibility of study results. This review informs future carbon footprint studies by highlighting understudied areas in hospital care and providing guidance for selecting specific services and pathways. https://doi.org/10.1289/EHP14754.","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"62 1","pages":"126002"},"PeriodicalIF":10.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Accelerating Action toward Carbon-Neutral Hospital Care.","authors":"Tim Stobernack,Emma J Kooistra,Hugo R W Touw","doi":"10.1289/ehp16623","DOIUrl":"https://doi.org/10.1289/ehp16623","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"15 1","pages":"121301"},"PeriodicalIF":10.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Male Rats Exposed to Aroclor 1221 and Vinclozolin.","authors":"Emily N Hilz, Ross Gillette, Lindsay M Thompson, David Crews, Andrea C Gore","doi":"10.1289/EHP15684","DOIUrl":"10.1289/EHP15684","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence supports an association of endocrine-disrupting chemical (EDC) exposures with adverse biological effects in humans and wildlife. Recent studies reveal that health consequences of environmental exposures may persist or emerge across generations. This creates a dual conundrum: that we are exposed to contemporary environmental chemicals overlaid upon the inheritance of our ancestors' exposure profiles. Even when legacy EDCs are phased out, they may remain relevant due to persistence in the environment together with intergenerational inheritance of their adverse biological effects. Thus, we all possess a body burden of legacy contaminants, and we are also increasingly exposed to new generations of EDCs.</p><p><strong>Objectives: </strong>We assessed the effects of direct and ancestral exposures to EDCs across six generations on anxiety-like behaviors in male rats using our \"two hits, three generations apart\" multigenerational EDC exposure experimental model. We investigated two classes of EDCs with distinct hormonal actions and historical use-the weakly estrogenic polychlorinated biphenyl (PCB) mixture Aroclor 1221 (A1221) and the anti-androgenic fungicide vinclozolin (VIN)-in both the maternal and paternal line. We also determined if a hormonal mechanism drives these effects across generations.</p><p><strong>Methods: </strong>Rats were gestationally exposed to A1221, VIN, or vehicle [dimethyl sulfoxide (DMSO)] in the F1 generation. Three generations later, the F4 generation was given the same or a different exposure. Anxiety-like behavior was measured in the open field test, light:dark box, and elevated plus maze across generations. Serum was collected at the end of the experiment, and concentrations of estradiol and corticosterone were analyzed.</p><p><strong>Results: </strong>Although direct exposure did not affect behavior in F1 males, ancestral exposure to VIN decreased anxiety-like behavior in the F3 paternal line compared to vehicle. In the F4 paternal line, ancestral A1221 followed by direct exposure to VIN increased anxiety-like behavior compared to controls. In the F6 maternal line, relative to vehicle, the double ancestral hits of A1221/VIN decreased anxiety-like behavior. Serum hormones weakly predicted behavioral changes in the F4 paternal line and were modestly affected in the F4 and F6 maternal lines.</p><p><strong>Discussion: </strong>Our data suggest that anxiety-like behavioral phenotypes emerge transgenerationally in male rats in response to EDC exposure and that multiple hits of either the same or a different EDC can increase the impact in a lineage-specific manner. https://doi.org/10.1289/EHP15684.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 12","pages":"127006"},"PeriodicalIF":10.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}