Environmental Health Perspectives最新文献

{"title":"China’s Clean\u0000Heating Policy and Effects on\u0000Blood Pressure in Rural Beijing Adults","authors":"Talia Sternbach,Sam Harper,Xiaoying Li,Collin Brehmer,Yuanxun Zhang,Wenlu Yuan,Shu Tao,Kaibing Xue,Kennedy Hirst,Guofeng Shen,Christopher Barrington-Leigh,Xiang Zhang,Brian Robinson,Ellison Carter,Jill Baumgartner","doi":"10.1021/ehp.6c00053","DOIUrl":"https://doi.org/10.1021/ehp.6c00053","url":null,"abstract":"Abstract Large-scale residential energy transitions from solid fuel to clean energy are promising strategies to mitigate climate change and improve population health, but rigorous evaluation of their impacts is rare. China’s Clean Heating Policy (CHP) aimed to transition tens of millions of households from coal to electric and gas-based space heating. Following evidence of policy-driven improvements in indoor air pollution and indoor temperature, we evaluated the CHP’s impact on blood pressure (BP). In winter 2018–2019, we enrolled 1,003 adults aged >40 years from 50 Beijing villages not yet treated by the CHP; 20 villages were treated during follow-up (winters 2019–2020 and 2021–2022). Brachial and central BP and covariates were measured during household visits by trained staff. Policy impacts were estimated using an extended two-way fixed-effects difference-in-differences approach with village-clustered standard errors and adjustment for key BP predictors to improve precision. We found evidence of reductions (in mmHg) in brachial systolic BP (−1.4, 95% confidence interval [CI]: −3.3, 0.5), central systolic BP (−1.5, 95% CI: −3.3, 0.4), brachial diastolic BP (−1.6, 95% CI: −2.9, −0.3), and central diastolic BP (−1.6, 95% CI: −2.9, −0.3) among villages treated by the CHP compared with those untreated. Treatment effects varied by the year villages were treated by the CHP (p for homogeneity = 0.00 to 0.14) with greater BP reductions among participants in earlier-treated villages. Household energy policies like the CHP may serve as effective population-level interventions to reduce BP in China and complement high-risk cardiovascular prevention strategies.","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"39 1","pages":""},"PeriodicalIF":10.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Childhood\u0000Cognitively Stimulating Activities\u0000on the Association between Prenatal and Early Postnatal Lead Exposure\u0000and Later Adulthood Cognitive Function","authors":"Ruby Hickman,Joyce JY Lin,Kaleigh A. McAlaine,Tracy Punshon,Brian P. Jackson,Matthew N. Barr,Felicitas B. Bidlack,Laura Germine,Scott M. Bartell,Joseph J. Mangano,Justin Farmer,Joel D. Schwartz,Rajarshi Mukherjee,Susan A. Korrick,Marc G. Weisskopf","doi":"10.1021/ehp.6c00105","DOIUrl":"https://doi.org/10.1021/ehp.6c00105","url":null,"abstract":"Abstract Introduction: Early lead exposure is linked to cognitive function in later adulthood. In animal studies, enriched environments appear to protect against adverse effects of lead exposure, but there has been limited exploration in humans. Our objective was to assess whether engagement in cognitively stimulating activities in childhood modifies the association between early lead exposure and later adult cognitive function. Methods: Participants come from the St. Louis Baby Tooth – Later Life Health Study (SLBT), a cohort study which recruited beginning in 2021. SLBT is composed of individuals primarily from the St. Louis, USA area who donated deciduous (baby) teeth to a prior study, the Baby Tooth Survey, in 1958–1972. Participants who completed a survey and cognitive testing were selected through stratified random sampling for tooth lead analysis. Prenatal and postnatal tooth dentin lead concentrations were measured in the donated teeth using laser ablation inductively coupled plasma mass spectrometry. A summary cognitive function score was derived from z-scored outcomes on six cognitive tests completed online through the TestMyBrain platform. Participation in cognitively stimulating activities at ages 6, 12, and 18 years was retrospectively assessed at the time of cognitive testing with the Rush Alzheimer’s Disease Center Lifetime Cognitive Activities scale. Results: From 4236 participants who completed the survey and cognitive tests, 717 had tooth metals analyzed, from which 704 had non-outlying lead measures and sufficient survey information. Participants were on average 62 years (SD = 3.6) at the time of cognitive testing, and 376 (53%) were female. The level of cognitively stimulating activities averaged across childhood modified the effect of second-trimester lead exposure on later adulthood cognitive function. For those with less-frequent childhood cognitively stimulating activities, 1 ppm higher second-trimester lead was associated with 0.34 (95% CI: −0.52, −0.16) SD lower later adulthood cognitive function, while the association among those with high cognitively stimulating activities was null (−0.02 SD, 95% CI: −0.12, 0.07). Results were robust to adjustment for additional childhood socioeconomic characteristics and restriction to white non-Hispanic race. Conclusions: Our work supports the hypothesis that engaging in cognitively stimulating activities in childhood, after earlier lead exposure, could buffer its deleterious effects on later adult cognitive function.","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"11 3 1","pages":"699-706"},"PeriodicalIF":10.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study to Explore\u0000the Application of Silicone\u0000Wristband-Based Chemical Exposure Assessment to Kidney Disease Epidemiology\u0000in Agricultural Workers","authors":"Melissa DeSantiago,Grant D. Tore,Nicholas J. Herkert,Heather M. Stapleton,Duncan Hay,Margarita Valenzuela,Jenny Ruedlinger,Ana M. Rule,Jordan R. Kuiper,Jeffrey J. Fadrowski,Catterina Ferreccio,Sandra Cortés A,Lesliam Quirós-Alcalá","doi":"10.1021/ehp.6c00319","DOIUrl":"https://doi.org/10.1021/ehp.6c00319","url":null,"abstract":"Abstract Exposure assessment in kidney disease epidemiology remains challenging because kidney function impairment may alter urinary chemical excretion, limiting the utility of urinary biomonitoring and highlighting the need for alternative tools. We combined targeted and nontargeted analyses of silicone wristbands worn by 43 male agricultural workers to characterize their personal chemical exposome and evaluate preliminary associations of these exposures, urinary biomarkers, and kidney health. Kidney function was assessed via estimated glomerular filtration rate (eGFR, mL/min/1.73m2). Pesticides were quantified in wristbands (worn 8–11 days) and spot urine samples using targeted analysis. A custom GC-HRMS nontargeted workflow was applied to examine potential chemical exposure differences from wristband measurements. Associations between pesticide exposure and kidney function were evaluated using minimally adjusted linear regression for continuous eGFR (β) and log-binomial regression for binary eGFR < 90 (prevalence ratio [PR]). Overall, our findings suggest that higher wristband pesticide concentrations may be associated with lower kidney function among participants. In adjusted models, a 10-fold increase in wristband chlorpyrifos concentration yielded a higher prevalence of eGFR < 90 (PR = 1.53; 95% CI: 0.99, 2.36). Oxyfluorfen detection was similarly associated with a higher prevalence of eGFR < 90 (PR = 2.38; 95% CI: 1.01, 5.61). Conversely, most urinary biomarkers showed no association, though specific gravity-corrected AMPA concentrations were inversely associated with eGFR < 90 (PR = 0.31; 95% CI: 0.11, 0.87). Exploratory nontargeted analysis identified 193 tentative features that were higher on wristbands from participants with eGFR < 90 and only one feature that was higher on wristbands from participants with eGFR ≥ 90. Silicone wristbands show promise for enhancing characterization of the personal chemical exposome and warrant further investigation as a complementary tool to urinary biomonitoring for reducing exposure misclassification in kidney disease epidemiology. These exploratory findings, based on a small sample, are hypothesis-generating and require validation through larger, longitudinal studies.","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"71 1","pages":""},"PeriodicalIF":10.4,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM_2.5 and 30-Day Readmission in Medicare Beneficiaries with Alzheimer's Disease and Related Dementias: Effect Modification by Neighborhood Green and Blue Space.","authors":"Garam Byun, Scott W Delaney, Daniel Mork, Mahima Kaur, Yongsoo Choi, Antonella Zanobetti, Jenny Jyoung Lee, Tarik Benmarhnia, Peter James, Francesca Dominici, Thomas M Gill, Danielle Braun, Michelle L Bell","doi":"10.1021/EHP.6c00147","DOIUrl":"10.1021/EHP.6c00147","url":null,"abstract":"<p><p>Hospital readmissions are a major concern among people living with Alzheimer's disease and related dementias (ADRD), contributing to substantial burden on patients, caregivers, and health care systems. We evaluated whether short-term exposure to fine particulate matter (PM_2.5) was associated with 30-day all-cause readmission among older adults with ADRD and whether residential green and blue space modified this association. We conducted a nationwide time-stratified case-crossover study using Medicare fee-for-service inpatient claims from 2000 to 2016 in the contiguous United States. We identified 30-day all-cause readmissions following the first index admission with ADRD. Daily modeled PM_2.5 concentrations were linked to residential ZIP Codes, and exposure windows up to lag 2 days were examined. Measures of green and blue space were derived from Landsat and Google Street View data. Conditional logistic regression was used to estimate associations between PM_2.5 and readmission with interaction terms used to evaluate effect modification by levels of green and blue space. Among 6,098,836 beneficiaries with an index admission with ADRD, 759,128 (12.4%) experienced a 30-day all-cause readmission. An interquartile range (IQR; 7.2 μg/m³) increase in PM_2.5 averaged over lag 0 to 2 days was associated with a higher risk of readmission (odds ratio: 1.010; 95% confidence interval: 1.006, 1.015). Associations were higher for beneficiaries with longer intervals to readmission (>7 days). Effect modification by green or blue space was not conclusive. These findings suggest that short-term PM_2.5 exposure may increase the risk of 30-day all-cause hospital readmission among Medicare beneficiaries with ADRD. Reducing ambient PM_2.5 exposure may help prevent avoidable readmissions and lessen burden on patients, caregivers, and health care systems.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"134 6","pages":"707-714"},"PeriodicalIF":10.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation of STopTox: A Novel Alternative\u0000Method (NAM) for Acute Systemic and Topical Toxicity","authors":"Ricardo Scheufen Tieghi,Cleber C. Melo-Filho,Holli-Joi Martin,José Teófilo Moreira-Filho,Tripp LaPratt,Dave Allen,Judy Strickland,Alexander Tropsha,Nicole Kleinstreuer,Eugene N. Muratov","doi":"10.1021/ehp.6c01195","DOIUrl":"https://doi.org/10.1021/ehp.6c01195","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"51 1","pages":"494-497"},"PeriodicalIF":10.4,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted Lipidomics Analysis of Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Small-for-Gestational Age (SGA) Delivery: An Exploratory Study in the Atlanta African American Maternal-Child Cohort, 2014-2020.","authors":"Kaitlin R Taibl, Anne L Dunlop, Paula-Dene C Nesbeth, Dana Boyd Barr, Kristal Maner-Smith, Xueyun Liu, Chih-Yu Chen, Elizabeth J Corwin, Kurunthachalam Kannan, Dean P Jones, Carmen J Marsit, Youran Tan, Stephanie M Eick, M Ryan Smith, Parinya Panuwet, P Barry Ryan, Donghai Liang","doi":"10.1021/EHP.6c00018","DOIUrl":"10.1021/EHP.6c00018","url":null,"abstract":"<p><p>Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) is associated with small-for-gestational age (SGA), an adverse pregnancy outcome indicative of intrauterine growth restriction (IUGR). Evidence from previous environmental epidemiologic work suggests that lipids contribute to this association through oxidative stress and inflammation. Therefore, we conducted an exploratory study by analyzing the maternal lipidome with the meet-in-the-middle approach to identify potential intermediates. In the Atlanta African American Maternal-Child Cohort, pregnant participants provided serum samples between 6 and 17 weeks gestation, which underwent targeted PFAS analysis (<i>N</i>: total = 513, SGA = 61) and untargeted lipidomics analysis (<i>N</i>: total = 330, SGA = 36). A lipidome-wide association study (LWAS) was conducted for PFNA, PFOA, PFOS, and PFHxS with multivariable regression and their mixture with quantile g-computation. A separate LWAS was performed for SGA with multivariable regression. Lipid pathway analysis was performed in LIPEA (Lipid Pathway Enrichment Analysis). Lipidomic signatures that overlapped between any PFAS LWAS and the SGA LWAS were considered intermediates. A simultaneous, 1-quartile increase in serum concentrations of PFNA, PFOA, PFOS, and PFHxS at early pregnancy was associated with a 43% increase in delivery of an SGA newborn (Odds Ratio = 1.43; 95% Confidence Interval = 1.02, 2.00). The overall mixture effect was driven by PFNA (weight = 0.42). There were 321 features associated with the PFAS mixture and 25 features associated with SGA in the maternal lipidome (all <i>p</i> < 0.05, but none remained significant after false discovery rate correction). After confirmation and annotation, three intermediate metabolites were identified, including phosphatidylinositol 18:1-20:4, phosphatidylcholine 32:0, and monoacylglycerol 18:0. The pathways for glycerophospholipid metabolism, retrograde endocannabinoid signaling, insulin resistance, and long-term depression were also enriched in the LWAS for PFNA, PFOA, PFOS, PFHxS, the PFAS mixture, and SGA. Global analysis of the maternal lipidome during early pregnancy revealed diverse bioactive lipid involvement in the PFAS-SGA association. Additional research is warranted to understand if antioxidants and anti-inflammatory nutrients would attenuate exposure effects on adverse maternal-child health outcomes.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"134 6","pages":"601-612"},"PeriodicalIF":10.9,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Associations Between Per- and Polyfluoroalkyl Substances and the Risk of Type 2 Diabetes: The Role of Genetic Susceptibility and Lipid Metabolism.","authors":"Xu Cheng, Junya Gao, Lu Liu, Lin Liu, Hong Guo, Jin Zhang, Yu Wang, Gaokun Qiu, Meian He","doi":"10.1021/EHP.6c00071","DOIUrl":"10.1021/EHP.6c00071","url":null,"abstract":"<p><p>To elucidate the sex-specific associations of per- and polyfluoroalkyl substances (PFASs) on type 2 diabetes (T2D) risk and to explore whether genetic susceptibility and baseline lipid profiles may help explain these associations. A nested case-control study including 985 matched case-control pairs from the Dongfeng-Tongji Cohort was conducted. Serum PFAS concentrations, T2D-related pathway polygenic risk scores (PRSs), blood lipid profiles, and plasma lipidomes were integrated. Conditional logistic regression, weighted quantile sum (WQS) regression, mediation analysis, and gene-environment interaction analysis were used to explore the associations and mechanisms. Sex-specific associations were observed between PFAS exposure and incident T2D, with PFOA and PFNA being associated with higher T2D risk in females. Liver-lipid pathway PRS strengthened these sex-specific associations. PFAS exposure was associated with triglyceride-related lipid profiles in females. Exploratory analyses suggested that the lipid score statistically accounted for part of the selected PFAS-T2D associations. <i>CYP19A1</i>-rs2414098 modified the association in females, with 50% mediation by the lipid score in the CC genotype (higher estrone). Baseline lipid profiles may partly account for the observed sex-specific associations between PFAS exposure and incident T2D. The observed effect modification by <i>CYP19A1</i> rs2414098 suggests that hormonal pathways may contribute to the sex-specific associations, although this hypothesis requires confirmation in studies with direct hormone measurements and experimental validation.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"134 6","pages":"688-698"},"PeriodicalIF":10.9,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"17α-Hydroxyprogesterone Mediates Mo-Induced Sperm-Mediated Transgenerational Inheritance of Impaired Spermatogenesis.","authors":"Kun Zhou, Xue Song, Yingtong Jiang, Mengyuan Zhu, Yanling Chen, Miaomiao Tang, Guohong Zhao, Yusheng Guan, Xiaoling Zhang, Yanhui Hu, Minjian Chen","doi":"10.1021/EHP.6c00223","DOIUrl":"10.1021/EHP.6c00223","url":null,"abstract":"<p><p>Growing evidence suggests that exposure to metals, such as molybdenum, contributes to significant health risks. However, very little is known about its potential male reproductive toxicity due to paternal exposure across generations. The aim of the present study was to investigate the male reproductive toxicity of paternal exposure to sodium molybdate (Na₂MoO₄) across generations and reveal the underlying mechanism. Adult F0 male C57 mice were administered sodium molybdate at doses of 0.01 and 0.1 mg/kg/day. The assessment included testicular toxicity evaluation and metabolomic profiling, followed by mechanistic studies <i>in vivo</i> and <i>in vitro</i> from F0 to F2. A large sample of case-control study including 958 subjects verified the findings. Reduced sperm counts and damages to seminiferous tubules across generations were observed in Mo-treated groups. Metabolomics analysis revealed a transgenerational elevation of 17α-hydroxyprogesterone (17α-OHP) in the testes of Mo-treated groups. Apoptosis and ferroptosis were enhanced in GC-2 cells in vitro after 17α-OHP treatment and were validated in vivo. Molecular competition experiments revealed that 17α-OHP competes for the NADPH binding site in FSP1, hindering FSP1's catalytic function, as supported by metabolomics analysis. Enzyme activity analysis found a reduction in FSP1 activity after 17α-OHP treatment, promoting ferroptosis and apoptosis in GC-2 cells in vitro. AHCY was identified as a potential target and was reduced after Mo exposure both <i>in vivo</i> and <i>in vitro</i>, accompanied by testicular DNA hypomethylation and elevated expression of key enzymes for 17α-OHP synthesis across generations, including Hsd3b and Cyp17a1. Human studies revealed that Mo exposure was associated with an increased risk of male infertility via 17α-OHP. This study innovatively elucidated the mechanisms by which paternal Mo exposure induced transgenerational male reproductive toxicity through metabolic and epigenetic alterations using human, mouse, and <i>in vitro</i> models.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"134 6","pages":"726-746"},"PeriodicalIF":10.9,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Urinary Triclosan Concentrations Across Gestation and Childhood with the Adolescent Gut Microbiome.","authors":"Hannah E Laue, Abby F Fleisch, Antonia M Calafat, Bruce P Lanphear, Kim M Cecil, Kimberly Yolton, Jessie P Buckley, Margaret R Karagas, Juliette C Madan, Amy D Willis, Joseph M Braun","doi":"10.1021/EHP.6c00017","DOIUrl":"10.1021/EHP.6c00017","url":null,"abstract":"<p><p>Research on the influence of repeated exposure to antimicrobial chemicals, such as triclosan, on the microbiome is lacking. The goal of this study was to elucidate the associations of time-varying urinary triclosan concentrations with the adolescent gut microbiome. We used data from a prospective cohort based in Cincinnati, OH (enrolled 2003-2006, n = 146), to assess the time-varying associations of urinary triclosan concentrations with adolescent (age ∼ 12 years) gut microbiome diversity and composition. Individuals ≥ 18-years-old were recruited during the second trimester of pregnancy, and urinary triclosan concentrations were measured in pregnant women up to 2 times in pregnancy and up to 7 times in the child from ages 1 through 12 years. At age ∼ 12 years, fecal microbiome diversity and composition was characterized with metagenomic sequencing. We estimated differences in the relative abundance of prevalent (≥50%) bacterial species and gene pathways using linear regression and generalized estimating equations to assess windows of heightened susceptibility adjusted for sociodemographic characteristics. Additionally, we examined sex-specific associations by including an interaction term. The adolescent median Shannon diversity was 3.5 (IQR: 3.3, 3.5). Higher gestational triclosan concentrations with lower gut microbiome diversity [β = -0.13 per 10-fold increase (95%CI: -0.24, -0.02)]. Triclosan concentrations were also positively associated with higher abundance of antibiotic resistance genes and differential abundance of some bacterial species, with the strongest associations observed in early life and at age 12 years. We also found differences depending on sex, with more significant associations observed among males. Our findings provide insight into windows of triclosan exposure that are relevant to gut microbiome composition and the impacts of antimicrobial agents.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"134 6","pages":"672-687"},"PeriodicalIF":10.9,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics Insights Linking Personal Care Products Exposure to Serum Lipid Profiles in Older Adults: The China BAPE Study.","authors":"Yongjun Situ, Xiaojie Guo, Huimin Ren, Jiankun Qian, Chenlong Li, Chenfeng Li, Xianwen Tang, Jiran Zhang, Xiaona Wang, Mengyao Wang, Yue Liang, Chenglei Qi, Lin Chen, Kaiyue Shao, Hongyang Cui, Song Tang, Chen Mao, Xiaoming Shi","doi":"10.1021/EHP.6c00011","DOIUrl":"10.1021/EHP.6c00011","url":null,"abstract":"<p><p>Personal care products (PCPs) are widespread environmental exposures, yet their combined and system-wide effects on serum lipid profiles in the aging population remain poorly understood. This study aimed to comprehensively assess the association between exposure to multiple PCPs and serum lipid profiles in healthy older adults and to explore underlying molecular pathways and biological mechanisms. We conducted a prospective panel study with five monthly follow-up surveys between September 2018 and January 2019 among 76 healthy older adults (60-69 years) in Jinan, China. This study measured urinary concentrations of PCPs, serum lipid markers, and multiomics profiles (transcriptomics, lipidomics, and metabolomics). We employed linear mixed-effects models to analyze exposure-outcome associations and integrated multiomics data with causal inference testing and Ingenuity Pathway Analysis to identify mediating biomolecules and biological mechanisms. Additional analyses examined the relationships of PCP exposures with inflammatory cytokines, oxidative stress biomarkers, and electrocardiographic (ECG) parameters to provide functional support for the identified pathways and their associated phenotypic consequences. Four PCPs [Benzophenone-2 (BP-2), Benzophenone-3 (BP-3), 4-Hydroxy benzophenone (4-OHBP), and Ethyl p-Hydroxybenzoate (EtP)] were significantly associated with altered serum lipid profiles. Multiomics analyses suggested their convergence on a PPAR-centered immunometabolic network, with S100 signaling identified as a novel activation pathway. Specifically, BP-2 was associated with patterns consistent with IL-4/IL-13-mediated alternative macrophage activation, while PPAR appeared to be involved in inflammatory polarization and metabolic reprogramming. Cytokine analysis revealed associations between BP-2 and key inflammatory mediators (e.g., IL-1β), oxidative stress assessment linked BP-2 exposure to elevated markers of oxidative damage (e.g., 8-PGF2α), and ECG analysis associated BP-2 exposure with altered cardiac electrophysiology (e.g., QRS duration). These multifaceted findings suggest associations between PCP exposures and serum lipid profiles, and highlight the potential contribution to cardiovascular risk. Our findings provide integrated, multilayered evidence suggesting associations between exposure to PCPs and alterations in serum lipid profiles in older adults, bridging exposure profiles, biomolecular perturbations, and subclinical functional changes. These results serve as a hypothesis-generating theoretical foundation that, pending confirmation in larger studies or experimental validation, advances the understanding of environmental metabolic disruption in aging populations.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"134 6","pages":"624-638"},"PeriodicalIF":10.9,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}