Environmental Health Perspectives最新文献

{"title":"Exposure to Drinking Water Trihalomethanes and Risk of Cancer: A Systematic Review of the Epidemiologic Evidence and Dose-Response Meta-Analysis.","authors":"Emilie Helte, Fredrik Söderlund, Melle Säve-Söderbergh, Susanna C Larsson, Agneta Åkesson","doi":"10.1289/EHP14505","DOIUrl":"10.1289/EHP14505","url":null,"abstract":"<p><strong>Background: </strong>Chlorination is a widespread method for drinking water disinfection that has the drawback of introducing potentially carcinogenic chemical by-products to drinking water.</p><p><strong>Objective: </strong>We systematically evaluated the epidemiologic evidence of exposure to trihalomethane (THM) disinfection by-products and risk of cancer.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of epidemiologic studies that assessed the association of exposure to residential concentrations of THMs with risk of cancer in adults. A protocol was preregistered in PROSPERO (CRD42023435491). PubMed, Embase, Web of Science, and Cochrane were searched for publications up to April 2024. Study selection and risk of bias appraisal using the National Toxicology Program Office of Health Assessment and Translation (NTP OHAT) tool was done in duplicate. Summary risk estimates were assessed using random effects meta-analysis and one-stage dose-response meta-analysis.</p><p><strong>Results: </strong>The literature search resulted in 2,022 records, of which 29 publications assessing 14 different cancers were eligible for inclusion. Summary relative risks (RRs) were estimated for bladder cancer and colorectal cancer based on 5,860 and 9,262 cases and 84,371 and 90,272 participants, respectively. The summary RR of bladder cancer for the highest exposed compared with the lowest was 1.33 (95% CI: 1.04, 1.71), and in the dose-response analysis, RRs were statistically significant above THM concentrations of <math><mrow><mn>41</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mi>L</mi></mrow></math>. For colorectal cancer, the summary RR was 1.15 (95% CI: 1.07, 1.24).</p><p><strong>Conclusion: </strong>According to the World Cancer Research Fund criteria, we found limited-suggestive evidence that THM in drinking water increases the risk of bladder and colorectal cancer at levels below current regulatory limits in the US and EU, indicating that these fail to protect against cancer in the general population. https://doi.org/10.1289/EHP14505.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"16001"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Disparities in Exposures to PFAS and Other Unregulated Industrial Drinking Water Contaminants in US Public Water Systems.","authors":"Aaron J Maruzzo, Amanda B Hernandez, Christopher H Swartz, Jahred M Liddie, Laurel A Schaider","doi":"10.1289/EHP14721","DOIUrl":"10.1289/EHP14721","url":null,"abstract":"<p><strong>Background: </strong>Unregulated contaminants in drinking water, such as per- and polyfluoroalkyl substances (PFAS), can contribute to cumulative health risks, particularly in overburdened and less-advantaged communities. To our knowledge, there has been no nationwide assessment of socioeconomic disparities in exposures to unregulated contaminants in drinking water.</p><p><strong>Objective: </strong>The goals of this study were to identify determinants of unregulated contaminant detection among US public water systems (PWSs) and evaluate disparities related to race, ethnicity, and socioeconomic status.</p><p><strong>Methods: </strong>We gathered data from the US Environmental Protection Agency's (US EPA's) Third Unregulated Contaminant Monitoring Rule (2013-2015), PWS characteristics, sociodemographic data, and suspected pollution sources from regulatory databases. We included four target contaminants (or classes) with industrial sources: PFAS, 1,4-dioxane, 1,1-dichloroethane, and chlorodifluoromethane (HCFC-22). Associations were evaluated with pairwise comparison tests and generalized logistic mixed-effects regression models for six dichotomous outcomes: detection of each of four target contaminants, detection of <math><mrow><mo>≥</mo><mn>1</mn></mrow></math> target contaminant, and PWS exceedance of <math><mrow><mo>≥</mo><mn>1</mn></mrow></math> US EPA health reference level that was in effect in 2017.</p><p><strong>Results: </strong>More than 97 million US residents were served by a PWS with detectable levels of 1,4-dioxane (22% of PWSs), HCFC-22 (5.8%), 1,1-dichloroethane (4.7%), and/or PFAS (4.0%). Unregulated contaminant detection was more frequent among large systems, urban systems, and systems using groundwater or a combination of groundwater and surface water. In comparison with PWSs with no detectable levels of these unregulated contaminants, PWSs with detectable levels served counties with higher proportions of Hispanic residents (17% vs. 13%), as did PWSs that exceeded EPA health reference levels in comparison with PWSs with no exceedances (18% vs. 14%). There were persistent positive associations between proportions of Hispanic residents and detections of target contaminants, even after accounting for pollution sources.</p><p><strong>Discussion: </strong>Previously, inequities in exposures to drinking water contaminants were underestimated because prior studies have focused on regulated contaminants. PWSs serving counties with more Hispanic residents, non-Hispanic Black residents, and urban households may benefit from additional resources to proactively mitigate unregulated chemical contamination. Future studies should evaluate factors underlying these disparities to promote actions that protect water quality for all residents. https://doi.org/10.1289/EHP14721.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17002"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Multifaceted Intervention (TEMP) for Prevention of Occupational Heat-Related Illness among Outdoor Workers in the Power Grid Industry: A Cluster Randomized Controlled Trial.","authors":"Ranyi Ding, Yutong Wang, Yuelin Yu, Xianglong Meng, Quanquan Gong, Yuchuan Tang, Jinhao Wang, Xianlin Mu, Huiping Li, Huziwei Zhou, Shengfeng Wang, Ping Liu","doi":"10.1289/EHP14172","DOIUrl":"10.1289/EHP14172","url":null,"abstract":"<p><strong>Background: </strong>Occupational heat-related illness (OHI) is a health threat to workers that can be fatal in severe cases. Effective and feasible measures are urgently needed to prevent OHI.</p><p><strong>Objectives: </strong>We evaluated the effectiveness of a multifaceted intervention, TEMP, in reducing the OHI risk among outdoor workers in the power grid industry.</p><p><strong>Methods: </strong>A cluster randomized controlled trial was conducted with power grid outdoor workers in Southern China from 4 July 2022 to 28 August 2022. Work groups were randomly allocated (1:1) to the intervention or control groups. The multifaceted intervention TEMP comprised mobile application (app)-based education training (T), personal protective equipment [PPE (E)], OHI risk monitoring (M), and educational posters (P). Four follow-ups were conducted every 2 wk after the trial began. The primary outcome was the OHI incidence, and the secondary outcome was PPE usage. The app usage was considered as the compliance of intervention in the intervention group. The primary analysis used was intention-to-treat analysis. Multilevel analyses using random effects logistic regression models were performed to compare the odds of OHI between the two groups, adjusted for individual-level (education and work position) and work-related (including water intake when feeling thirsty, cooling measures, and poor sleep before work) covariates.</p><p><strong>Results: </strong>Of 528 participants, 422 (79.92%) were males, and the <math><mrow><mtext>mean</mtext><mo>±</mo><mtext>SD</mtext></mrow></math> age was <math><mrow><mn>36.36</mn><mo>±</mo><mn>8.18</mn></mrow></math> y. The primary outcome, OHI incidence, was 1.80% in the intervention group and 4.82% in the control group at the end of the whole follow-up. OHI mainly occurred between 1100 and 1500 hours, with nausea, significantly increased heart rate, and oliguria being the top three reported OHI symptoms. Compared with the control group, the adjusted odds ratios between the intervention group and control group were 0.73 [95% confidence interval (CI): 0.30, 1.76] in the first follow-up wave, with 0.38 (95% CI: 0.15, 0.97), 0.29 (95% CI: 0.08, 1.05), and 0.39 (95% CI: 0.13, 1.19) in the following three follow-up waves, respectively. The intervention also significantly improved PPE usage in the intervention group.</p><p><strong>Discussions: </strong>This multifaceted intervention reduced the OHI risk among outdoor workers in the power grid industry. However, further research is needed to design a more flexible intervention strategy and evaluate its effectiveness in a larger population. https://doi.org/10.1289/EHP14172.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17001"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Critical Needs for Advancing Beauty Justice.","authors":"Ami R Zota, Eva L Siegel","doi":"10.1289/EHP16497","DOIUrl":"10.1289/EHP16497","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"11302"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Variation in the Association between Extreme Heat Events and Warm Season Pediatric Acute Care Utilization: A Small-Area Assessment of Multiple Health Conditions and Environmental Justice Implications in California (2005-2019).","authors":"Allan Ndovu, Chen Chen, Lara Schwarz, Emma Lasky, Sheri D Weiser, Tarik Benmarhnia","doi":"10.1289/EHP14236","DOIUrl":"10.1289/EHP14236","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The increasing frequency and severity of extreme heat events due to climate change present unique risks to children and adolescents. There is a lack of evidence regarding how heat's impacts on pediatric patients vary spatially and how structural and sociodemographic factors drive this heterogeneity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;We examined the association between extreme heat events and pediatric acute care utilization in California for 19 distinct health conditions. We then assessed how extreme heat's consequences varied at the ZIP code level and identified environmental justice metrics that modulated children's vulnerability to extreme heat.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study analyzed 7.2 million unscheduled hospitalizations and emergency department visits for children &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;&lt;&lt;/mo&gt;&lt;mn&gt;19&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; years old in California between May and September from 2005 to 2019. We first utilized a time-stratified case-crossover design to generate statewide estimates for the association between extreme heat events and care utilization. We then implemented a within-community matched design coupled with a Bayesian hierarchical model to generate spatially varying effect estimates. Finally, we conducted a random effects meta-regression to examine how community-level characteristics modified heat's impacts across ZIP codes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Extreme heat events were associated with substantial increases in acute care utilization for all causes [odds ratio &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;mtext&gt;OR&lt;/mtext&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1.03&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% confidence interval (CI): 1.03, 1.04] and were attributable for over 30,000 excess acute care utilizations during the study period. Extreme heat events were also associated with increases in heat-related illness (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;OR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1.53&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 1.49, 1.58); endocrine, nutritional, and metabolic disorders (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;OR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1.13&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 1.1, 1.16); other signs and symptoms (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;OR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1.07&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 1.06, 1.08); and injury and poisoning (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;OR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1.07&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 1.05, 1.08). There was substantial spatial heterogeneity in extreme heat events effects, especially in coastal metropolitan areas. Communities with lower incomes and education levels, less access to insurance and air conditioning, and higher percentages of Black, Hispanic, and Pacific Islander residents were most vulnerable during extreme heat events.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Extreme heat events in California are associated with increased pediatric care utilization. There is significant variation in heat's consequences, and historically disadvantaged and under-resourced communities are most impacted. These findings suggest that interventions designed to improve heat resilience should be tar","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17010"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic.","authors":"Kiran Makhani, Xiuhui Yang, France Dierick, Nivetha Subramaniam, Natascha Gagnon, Talin Ebrahimian, Stephanie Lehoux, Hao Wu, Jun Ding, Koren K Mann","doi":"10.1289/EHP14285","DOIUrl":"10.1289/EHP14285","url":null,"abstract":"<p><strong>Background: </strong>Millions worldwide are exposed to elevated levels of arsenic that significantly increase their risk of developing atherosclerosis, a pathology primarily driven by immune cells. While the impact of arsenic on immune cell populations in atherosclerotic plaques has been broadly characterized, cellular heterogeneity is a substantial barrier to in-depth examinations of the cellular dynamics for varying immune cell populations.</p><p><strong>Objectives: </strong>This study aimed to conduct single-cell multi-omics profiling of atherosclerotic plaques in apolipoprotein E knockout (<i>ApoE</i>^-/-) mice to elucidate transcriptomic and epigenetic changes in immune cells induced by arsenic exposure.</p><p><strong>Methods: </strong>The <i>ApoE</i>^-/- mice were fed a high-fat diet and were exposed to either <math><mrow><mn>200</mn><mtext> ppb</mtext></mrow></math> arsenic in drinking water or a tap water control, and single-cell multi-omics profiling was performed on atherosclerotic plaque-resident immune cells. Transcriptomic and epigenetic changes in immune cells were analyzed within the same cell to understand the effects of arsenic exposure.</p><p><strong>Results: </strong>Our data revealed that the transcriptional profile of macrophages from arsenic-exposed mice were significantly different from that of control mice and that differences were subtype specific and associated with cell-cell interaction and cell fates. Additionally, our data suggest that differences in arsenic-mediated changes in chromosome accessibility in arsenic-exposed mice were statistically more likely to be due to factors other than random variation compared to their effects on the transcriptome, revealing markers of arsenic exposure and potential targets for intervention.</p><p><strong>Discussion: </strong>These findings in mice provide insights into how arsenic exposure impacts immune cell types in atherosclerosis, highlighting the importance of considering cellular heterogeneity in studying such effects. The identification of subtype-specific differences and potential intervention targets underscores the significance of understanding the molecular mechanisms underlying arsenic-induced atherosclerosis. Further research is warranted to validate these findings and explore therapeutic interventions targeting immune cell dysfunction in arsenic-exposed individuals. https://doi.org/10.1289/EHP14285.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17007"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valley Fever: Fine Mineral Dust Modeling Points to High-Risk Regions and Seasons in California.","authors":"Silke Schmidt","doi":"10.1289/EHP16213","DOIUrl":"10.1289/EHP16213","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"14002"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Drinking Water Disinfection By-Products and Cancer-A Historical Perspective.","authors":"Cristina M Villanueva","doi":"10.1289/EHP16443","DOIUrl":"10.1289/EHP16443","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"11303"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Maternal BPA Exposure during Pregnancy on Obesity in Male Offspring: A Mechanistic Mouse Study of Adipose-Derived Exosomal miRNA.","authors":"Zhenyao Huang, Rui Niu, Qiaoqiao Xu, Rui Zhang, Weiyue Hu, Yufeng Qin, Xinru Wang, Qiujin Xu, Yankai Xia, Yun Fan, Chuncheng Lu","doi":"10.1289/EHP14888","DOIUrl":"10.1289/EHP14888","url":null,"abstract":"<p><strong>Background: </strong>The widespread use of bisphenol A (BPA) has led to universal exposure among the population, raising concerns about its health effects. Epidemiological studies have linked environmentally relevant levels of BPA exposure to obesity.</p><p><strong>Objectives: </strong>We aimed to uncover the complex mechanisms by which oral exposure during pregnancy with BPA affects the offspring.</p><p><strong>Methods: </strong>We conducted a two-stage mouse study. In stage 1, we gavaged dams with BPA at 0.05, 0.5, and <math><mrow><mn>5</mn><mspace></mspace><mi>mg</mi><mo>/</mo><mi>kg</mi><mtext> per day</mtext></mrow></math> during pregnancy, and we tracked the offspring's weight and diet to 12 wk of age. In stage 2, exosomes from BPA-exposed dams and offspring were injected into pregnant mice and 3-wk-old males, respectively, and the mice were observed up to 12 wk. We then sequenced exosomal microRNAs (miRNAs) in male offspring whose dams had been exposed to BPA during pregnancy and checked their expression in adipose, liver, and serum samples at weeks 3, 6, 9, and 12. Finally, we explored the functions of exosomes and exosomal miRNAs secreted by adipose-derived mesenchymal stem cells, and we investigated whether the exosomes and miRNAs they secreted could affect glucose uptake, triglyceride synthesis, and the expression of genes related to glucose and lipid metabolism in alpha mouse liver 12 cells.</p><p><strong>Results: </strong>Gavage of <math><mrow><mn>0.05</mn><mspace></mspace><mi>mg</mi><mo>/</mo><mi>kg</mi><mtext> per day</mtext></mrow></math> of BPA during pregnancy in dams led to obesity in male offspring mice, and injection of exosomes from male offspring with BPA exposure during pregnancy also induced similar outcomes in the next generation of male pups. Exosomal miRNA sequencing identified differentially expressed miRNAs associated with BPA-induced obesity in male offspring, revealing sustained high expression of miRNAs in adipose tissue and a gradual increase in the liver and serum over time. Further mechanistic studies showed that exosomes derived from BPA-treated adipose-derived stem cells reduced the expression of peroxisome proliferator-activated receptor-gamma and fibroblast growth factor 21, leading to impaired insulin signaling and lipid metabolism in hepatocytes. Overexpression of miR-124-3p in hepatocytes mimicked these effects; in contrast, knockdown of miR-124-3p or inhibition of exosome secretion reversed them.</p><p><strong>Discussion: </strong>The present study corroborates the regulatory function of adipose-derived exosomal miRNAs in obesity in male offspring mice resulting from BPA exposure during pregnancy. Exosomal miRNA may be a key and novel molecular biomarker in the adverse effects of chemical exposure during pregnancy. https://doi.org/10.1289/EHP14888.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"17011"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When It Rains It Pours: <i>Campylobacter</i> Infection Rates after Rain on Wet and Dry Soils.","authors":"Charles Schmidt","doi":"10.1289/EHP16432","DOIUrl":"10.1289/EHP16432","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 1","pages":"14001"},"PeriodicalIF":10.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}