Environmental Health Perspectives最新文献

{"title":"Erratum: \"Impact of Skin Care Products on Phthalates and Phthalate Replacements in Children: The ECHO-FGS\".","authors":"Michael S Bloom, Juliana M Clark, John L Pearce, Pamela L Ferguson, Roger B Newman, James R Roberts, William A Grobman, Anthony C Sciscione, Daniel W Skupski, Kelly Garcia, John E Vena, Kelly J Hunt","doi":"10.1289/EHP16591","DOIUrl":"https://doi.org/10.1289/EHP16591","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 11","pages":"119001"},"PeriodicalIF":10.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asking Why Is Necessary to Address Health Disparities: A Critical Approach for Solution-Oriented Environmental Epidemiological Research.","authors":"Tamarra James-Todd, Kathryn S Tomsho, Symielle A Gaston, Kevin C Elliott, Chandra L Jackson","doi":"10.1289/EHP14513","DOIUrl":"10.1289/EHP14513","url":null,"abstract":"<p><strong>Background: </strong>In environmental epidemiology, we use an array of tools from various, related disciplines to answer key questions about environmental exposures in relation to health outcomes. Typically, we ask questions related to what, who, where, when, and how. We value these questions because they contribute to novel scientific discovery and our understanding of disease etiology linked to environmental exposures. In addition, these questions help us better understand who might be at highest risk of exposure and subsequent risk of disease. Although necessary for the goals of environmental epidemiology, these questions are insufficient for addressing environmental health disparities. Specifically, these questions may be able to help us describe exposure-health outcome associations but are limited in their ability to move beyond identification to intervening on observed disparities to achieve environmental health equity.</p><p><strong>Objectives: </strong>We sought to emphasize the need to value and routinely add the key question of \"Why?\" in environmental epidemiological studies. In asking this additional critical question, we can identify and incorporate the structural determinants and drivers of environmental exposure disparities and determine whether these factors are linked to existing and historically recalcitrant health disparities. Further, we can design effective studies that build on existing frameworks to address the fundamental causes of environmental health disparities.</p><p><strong>Discussion: </strong>This commentary underscores the need to routinely incorporate \"why\" questions in the practice of environmental epidemiology. By asking and addressing \"Why?\" we can employ better, more solution-oriented study designs, improve data collection, and enhance our ability to collaborate with diverse study populations through trust-building and community-engaged research. Incorporating these approaches will move environmental epidemiology forward from mostly documenting to actively addressing environmental health disparities. https://doi.org/10.1289/EHP14513.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 11","pages":"115001"},"PeriodicalIF":10.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Associations between Changes in Exposure to Air Pollutants due to Relocation and the Incidence of 14 Major Disease Categories and All-Cause Mortality: A Natural Experiment Study\".","authors":"Ziwei Gao, Jiachen Qi, Wei Ye","doi":"10.1289/EHP16404","DOIUrl":"10.1289/EHP16404","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 11","pages":"118001"},"PeriodicalIF":10.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study.","authors":"Aizhen Wang,&nbsp;Yanjian Wan,&nbsp;Gaga Mahai,&nbsp;Xi Qian,&nbsp;Yuanyuan Li,&nbsp;Shunqing Xu,&nbsp;Wei Xia","doi":"10.1289/EHP12097","DOIUrl":"10.1289/EHP12097","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Widespread insecticide exposure might be a risk factor for neurodevelopment of our children, but few studies examined the mixture effect of maternal coexposure to organophosphate insecticides (OPPs), pyrethroids (PYRs), and neonicotinoid insecticides (NNIs) during pregnancy on child neurodevelopment, and critical windows of exposure are unknown.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;We aimed to evaluate the association of prenatal exposure to multiple insecticides with children's neurodevelopment and to identify critical windows of the exposure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Pregnant women were recruited into a prospective birth cohort study in Wuhan, China, from 2014-2017. Eight metabolites of OPPs (mOPPs), three metabolites of PYRs (mPYRs), and nine metabolites of NNIs (mNNIs) were measured in 3,123 urine samples collected at their first, second, and third trimesters. Children's neurodevelopment [mental development index (MDI) and psychomotor development index (PDI)] was assessed using the Bayley Scales of Infant Development at 2 years of age (&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;N&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1,041&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;). Multivariate linear regression models, generalized estimating equation models, and weighted quantile sum (WQS) regression were used to estimate the association between the insecticide metabolites and Bayley scores. Potential sex-specific associations were also examined.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Single chemical analysis suggested higher urinary concentrations of some insecticide metabolites at the first trimester were significantly associated with lower MDI and PDI scores, and the associations were more prominent among boys. Each 1-unit increase in ln-transformed urinary concentrations of two mOPPs, 3,5,6-trichloro-2-pyridinol and 4-nitrophenol, was associated with a decrease of 3.16 points [95% confidence interval (CI): &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;5.59&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.74&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;] and 3.06 points (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;5.45&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.68&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;) respectively in boys' MDI scores. Each 1-unit increase in that of &lt;i&gt;trans&lt;/i&gt;-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid (&lt;i&gt;trans&lt;/i&gt;-DCCA; an mPYR) was significantly associated with a decrease of 2.24 points (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;3.89&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.58&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;) in boys' MDI scores and 1.90 points (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;3.16&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.64&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;) in boys' PDI scores, respectively. Significantly positive associations of maternal urinary biomarker concentrations [e.g., dimethyl phosphate (a nonspecific mOPP) and desmethyl-clothianidin (a relatively specific mNNI)] with child neurodevelopment were also observed. Using repeated holdout validation, a 1-quartile increase in the WQS index of the insecticide mixture (in the negative di","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"131 10","pages":"107011"},"PeriodicalIF":10.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49675710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Wind and Flood: Review of Cyclone Research Spotlights Trauma Outcomes.","authors":"Charles Schmidt","doi":"10.1289/EHP13761","DOIUrl":"10.1289/EHP13761","url":null,"abstract":"A solemn man carrying a red walks along the road in a storm-damaged neighborhood.","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"131 10","pages":"104002"},"PeriodicalIF":10.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study.","authors":"Parisa Montazeri, Nuria Güil-Oumrait, Sandra Marquez, Lourdes Cirugeda, Andrea Beneito, Mònica Guxens, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Loreto Santa-Marina, Jordi Sunyer, Maribel Casas, Martine Vrijheid","doi":"10.1289/EHP11103","DOIUrl":"10.1289/EHP11103","url":null,"abstract":"<p><strong>Background: </strong>Prenatal exposure to endocrine-disrupting chemicals (EDCs) may disrupt normal fetal and postnatal growth. Studies have mainly focused on individual aspects of growth at specific time points using single chemical exposure models. However, humans are exposed to multiple EDCs simultaneously, and growth is a dynamic process.</p><p><strong>Objective: </strong>The objective of this study was to evaluate the associations between prenatal exposure to EDCs and children's body mass index (BMI) growth trajectories using single exposure and mixture modeling approaches.</p><p><strong>Methods: </strong>Using data from the INfancia y Medio Ambiente (INMA) Spanish birth cohort (<math><mrow><mi>n</mi><mo>=</mo><mn>1,911</mn></mrow></math>), prenatal exposure to persistent chemicals [hexachlorobenzene (HCB), 4-4'-dichlorodiphenyldichloroethylene (DDE), polychlorinated biphenyls (PCB-138, -150, and -180), 4 perfluoroalkyl substances (PFAS)] and nonpersistent chemicals (8 phthalate metabolites, 7 phenols) was assessed using blood and spot urine concentrations. BMI growth trajectories were calculated from birth to 9 years of age using latent class growth analysis. Multinomial regression was used to assess associations for single exposures, and Bayesian weighted quantile sum (BWQS) regression was used to evaluate the EDC mixture's association with child growth trajectories.</p><p><strong>Results: </strong>In single exposure models exposure to HCB, DDE, PCBs, and perfluorononanoic acid (PFNA) were associated with increased risk of belonging to a trajectory of lower birth size followed by accelerated BMI gain by 19%-32%, compared with a trajectory of average birth size and subsequent slower BMI gain [e.g., relative risk ratio (RRR) per doubling in DDE <math><mrow><mtext>concentration</mtext><mo>=</mo><mn>1.19</mn></mrow></math> (95% CI: 1.05, 1.35); RRR for <math><mrow><mtext>PFNA</mtext><mo>=</mo><mn>1.32</mn></mrow></math> (95% CI: 1.05, 1.66)]. HCB and DDE exposure were also associated with higher probability of belonging to a trajectory of higher birth size and accelerated BMI gain. Results from the BWQS regression showed the mixture was positively associated with increased odds of belonging to a BMI trajectory of lower birth size and accelerated BMI gain (odds ratio per 1-quantile increase of the <math><mrow><mtext>mixture</mtext><mo>=</mo><mn>1.70</mn></mrow></math>; credible interval: 1.03, 2.61), with HCB, DDE, and PCBs contributing the most.</p><p><strong>Discussion: </strong>This study provides evidence that prenatal EDC exposure, particularly persistent EDCs, may lead to BMI trajectories in childhood characterized by accelerated BMI gain. Given that accelerated growth is linked to a higher disease risk in later life, continued research is important. https://doi.org/10.1289/EHP11103.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"131 10","pages":"107006"},"PeriodicalIF":10.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Exposure to Walkable Residential Neighborhoods and Risk of Obesity-Related Cancer in the New York University Women's Health Study (NYUWHS).","authors":"Sandra India-Aldana, Andrew G Rundle, James W Quinn, Tess V Clendenen, Yelena Afanasyeva, Karen L Koenig, Mengling Liu, Kathryn M Neckerman, Lorna E Thorpe, Anne Zeleniuch-Jacquotte, Yu Chen","doi":"10.1289/EHP11538","DOIUrl":"10.1289/EHP11538","url":null,"abstract":"<p><strong>Background: </strong>Living in neighborhoods with higher levels of walkability has been associated with a reduced risk of obesity and higher levels of physical activity. Obesity has been linked to increased risk of 13 cancers in women. However, long-term prospective studies of neighborhood walkability and risk for obesity-related cancer are scarce.</p><p><strong>Objectives: </strong>We evaluated the association between long-term average neighborhood walkability and obesity-related cancer risk in women.</p><p><strong>Methods: </strong>The New York University Women's Health Study (NYUWHS) is a prospective cohort with 14,274 women recruited between 1985 and 1991 in New York City and followed over nearly three decades. We geocoded residential addresses for each participant throughout follow-up and calculated an average annual measure of neighborhood walkability across years of follow-up using data on population density and accessibility to destinations associated with geocoded residential addresses. We used ICD-9 codes to characterize first primary obesity-related cancers and employed Cox proportional hazards models to assess the association between average neighborhood walkability and risk of overall and site-specific obesity-related cancers.</p><p><strong>Results: </strong>Residing in neighborhoods with a higher walkability level was associated with a reduced risk of overall and site-specific obesity-related cancers. The hazards ratios associated with a 1-standard deviation increase in average annual neighborhood walkability were 0.88 (95% CI: 0.85, 0.93) for overall obesity-related cancer, 0.89 (95% CI: 0.84, 0.95) for postmenopausal breast cancer, 0.82 (95% CI: 0.68, 0.99) for ovarian cancer, 0.87 (95% CI: 0.76, 0.99) for endometrial cancer, and 0.68 (95% CI: 0.49, 0.94) for multiple myeloma, adjusting for potential confounders at both the individual and neighborhood level. The association between neighborhood walkability and risk of overall obesity-related cancer was stronger among women living in neighborhoods with higher levels of poverty compared with women living in areas with lower poverty levels (<math><mrow><msub><mrow><mi>p</mi></mrow><mrow><mrow><mtext>Interaction</mtext></mrow></mrow></msub><mo>=</mo><mn>0.006</mn></mrow></math>).</p><p><strong>Discussion: </strong>Our study highlights a potential protective role of neighborhood walkability in preventing obesity-related cancers in women. https://doi.org/10.1289/EHP11538.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"131 10","pages":"107001"},"PeriodicalIF":10.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Metabolic Differences Associated with Exposure to Polybrominated Biphenyl and Polychlorinated Biphenyls in the Michigan PBB Registry.","authors":"Susan S Hoffman, Donghai Liang, Robert B Hood, Youran Tan, Metrecia L Terrell, M Elizabeth Marder, Hillary Barton, Melanie A Pearson, Douglas I Walker, Dana Boyd Barr, Dean P Jones, Michele Marcus","doi":"10.1289/EHP12657","DOIUrl":"10.1289/EHP12657","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Polybrominated biphenyls (PBB) and polychlorinated biphenyls (PCB) are persistent organic pollutants with potential endocrine-disrupting effects linked to adverse health outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;In this study, we utilize high-resolution metabolomics (HRM) to identify internal exposure and biological responses underlying PCB and multigenerational PBB exposure for participants enrolled in the Michigan PBB Registry.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;HRM profiling was conducted on plasma samples collected from 2013 to 2014 from a subset of participants enrolled in the Michigan PBB Registry, including 369 directly exposed individuals (F0) who were alive when PBB mixtures were accidentally introduced into the food chain and 129 participants exposed to PBB &lt;i&gt;in utero&lt;/i&gt; or through breastfeeding, if applicable (F1). Metabolome-wide association studies were performed for PBB-153 separately for each generation and &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Σ&lt;/mi&gt;&lt;mtext&gt;PCB&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt; (PCB-118, PCB-138, PCB-153, and PCB-180) in the two generations combined, as both had direct PCB exposure. Metabolite and metabolic pathway alterations were evaluated following a well-established untargeted HRM workflow.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Mean levels were &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;1.75&lt;/mn&gt;&lt;mtext&gt; ng&lt;/mtext&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;mL&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt; [standard deviation (SD): 13.9] for PBB-153 and &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;1.04&lt;/mn&gt;&lt;mtext&gt; ng&lt;/mtext&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;mL&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt; (SD: 0.788) for &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Σ&lt;/mi&gt;&lt;mtext&gt;PCB&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt;. Sixty-two and 26 metabolic features were significantly associated with PBB-153 in F0 and F1 [false discovery rate (FDR) &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;&lt;&lt;/mo&gt;&lt;mn&gt;0.2&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;], respectively. There were 2,861 features associated with &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Σ&lt;/mi&gt;&lt;mtext&gt;PCB&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt; (FDR &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;&lt;&lt;/mo&gt;&lt;mn&gt;0.2&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;). Metabolic pathway enrichment analysis using a bioinformatics tool revealed perturbations associated with &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Σ&lt;/mi&gt;&lt;mtext&gt;PCB&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt; in numerous oxidative stress and inflammation pathways (e.g., carnitine shuttle, glycosphingolipid, and vitamin B9 metabolism). Metabolic perturbations associated with PBB-153 in F0 were related to oxidative stress (e.g., pentose phosphate and vitamin C metabolism) and in F1 were related to energy production (e.g., pyrimidine, amino sugars, and lysine metabolism). Using authentic chemical standards, we confirmed the chemical identity of 29 metabolites associated with &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Σ&lt;/mi&gt;&lt;mtext&gt;PCB&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt; levels (level 1 evidence).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our results demonstrate that serum PBB-153 is associated with alterations in inflammation and oxidative stress-related pathways, which differed when stratified by generation. We also found that &lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Σ&lt;/mi&gt;&lt;mtext&gt;PCB&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt; was associated with the downregulation of important neurotransmitters,","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"131 10","pages":"107005"},"PeriodicalIF":10.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41195443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Glyphosate, 2,4-D and DEET Biomarkers in Relation to Neurobehavioral Performance in Ecuadorian Adolescents in the ESPINA Cohort.","authors":"Briana N C Chronister, Kun Yang, Audrey R Yang, Tuo Lin, Xin M Tu, Dolores Lopez-Paredes, Harvey Checkoway, Jose Suarez-Torres, Sheila Gahagan, Danilo Martinez, Dana Barr, Raeanne C Moore, Jose R Suarez-Lopez","doi":"10.1289/EHP11383","DOIUrl":"10.1289/EHP11383","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Herbicides are the most used class of pesticides worldwide, and insect repellents are widely used globally. Yet, there is a dearth of studies characterizing the associations between these chemical groups and human neurobehavior. Experimental studies suggest that glyphosate and 2,4-dichlorophenoxyacetic acid (2,4-D) herbicides can affect neurobehavior and the cholinergic and glutamatergic pathways in the brain. We aim to assess whether herbicides and insect repellents are associated with neurobehavioral performance in adolescents.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We assessed 519 participants (11-17 years of age) living in agricultural communities in Ecuador. We quantified urinary concentrations of glyphosate, 2,4-D, and two N,N-diethyl-meta-toluamide (DEET) insect repellent metabolites [3-(diethylcarbamoyl)benzoic acid (DCBA) and 3-(ethylcarbamoyl)benzoic acid (ECBA)] using isotope-dilution mass spectrometry. We assessed neurobehavioral performance using 9 subtests across 5 domains (attention/inhibitory control, memory/learning, language, visuospatial processing, and social perception). We characterized the associations using generalized estimating equations and multiple imputation for metabolites below detection limits. Models were adjusted for demographic and anthropometric characteristics, urinary creatinine, and sexual maturation. Mediation by salivary cortisol, dehydroepiandrosterone, &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;17&lt;/mn&gt;&lt;mi&gt;β&lt;/mi&gt;&lt;mtext&gt;-estradiol&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt;, and testosterone was assessed using structural equation modeling.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The mean of each neurobehavioral domain score was between 7.0 and 8.7 [standard deviation (SD) range: 2.0-2.3]. Glyphosate was detected in 98.3% of participants, 2,4-D in 66.2%, DCBA in 63.3%, and ECBA in 33.4%. 2,4-D was negatively associated with all neurobehavioral domains, but statistically significant associations were observed with attention/inhibition [score difference per 50% higher metabolite concentration &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;mi&gt;β&lt;/mi&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;/mrow&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.19&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; 95% confidence interval (CI): &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.31&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.07&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;], language [&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;β&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.12&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.23&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.01&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;)], and memory/learning [&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;β&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.11&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.22&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, 0.01)]. Glyphosate had a statistically significant negative association only with social perception [&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;β&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.08&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.14&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.01&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;)]. DEET metabolites were not associated with neurobehavioral performance. Mediation by gender and adrenal","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"131 10","pages":"107007"},"PeriodicalIF":10.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41195445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and Polyfluoroalkyl Substances and Anti-Müllerian Hormone Concentrations in Two Preconception Cohort Studies.","authors":"Lauren A Wise, Tanran R Wang, Ellen M Mikkelsen, Amelia K Wesselink, Antonia M Calafat, Ganesa Wegienka, Ruth J Geller, Chad M Coleman, Mary D Willis, Erica E Marsh, Samantha Schildroth, Julianne C Botelho, Geralyn Messerlian-Lambert, Elizabeth E Hatch","doi":"10.1289/EHP12592","DOIUrl":"10.1289/EHP12592","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"131 10","pages":"107703"},"PeriodicalIF":10.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}