Advancing Exposomics: From Concept to Practice in Environmental Health Sciences.

IF 9.8 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Health Perspectives Pub Date : 2025-06-12 DOI:10.1289/EHP15561

Alison A Motsinger-Reif, David M Balshaw, Linda S Birnbaum, Yuxia Cui, Curt T DellaValle, Cinnamon A Dixon, Erin Iturriaga, David A Jett, Aubrey K Miller, Victoria K Shanmugam, Sarah M Temkin, Richard K Kwok

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Abstract

Background: Exposomics is a conceptual framework positioned at the intersection of environmental health sciences and precision medicine. It seeks to comprehensively understand how environmental exposures and the body's response to these exposures impact human health across the life course. Introduced in 2005, the exposome concept represents a paradigm shift from single-pollutant studies to an integrated approach considering a broad range of exposures.

Objectives: This commentary explores the ongoing efforts to operationalize the exposome, with a focus on NIH initiatives aimed at building capacity in exposomics research and integrating lifecourse exposure data into health research.

Methods: This commentary draws on a structured review of current NIH funding opportunities, initiatives, and strategic documents related to exposomics. Key NIH-supported projects and collaborations were identified through analysis of publicly available agency reports, grant announcements, and program descriptions. Additional insights were gathered from relevant literature and international research activities to contextualize the NIH's role in promoting exposomics and integrating life-course exposure data into health research.

Discussion: Operationalizing the exposome is essential for advancing the field of environmental health and precision medicine. NIH-supported initiatives, alongside international collaborations, aim to standardize methodologies, develop tools, and promote interdisciplinary research. Addressing the complexities of exposomics requires integrating diverse datasets and fostering global coordination, paving the way for innovative strategies to improve human health outcomes. https://doi.org/10.1289/EHP15561.

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推进暴露学：从概念到环境健康科学的实践。

背景：暴露组学是一种定位于环境健康科学和精准医学交叉领域的概念框架。它旨在全面了解环境暴露和人体对这些暴露的反应如何影响人类整个生命过程中的健康。暴露量概念于2005年提出，代表了从单一污染物研究向考虑广泛暴露的综合方法的范式转变。目的：本评论探讨了正在进行的将暴露体付诸实施的努力，重点是美国国立卫生研究院旨在建立暴露体研究能力和将生命过程暴露数据纳入健康研究的举措。方法：这篇评论借鉴了当前NIH资助机会、倡议和与暴露学相关的战略文件的结构化审查。通过分析公开的机构报告、拨款公告和项目描述，确定了nih支持的关键项目和合作。从相关文献和国际研究活动中收集了更多的见解，以确定NIH在促进暴露组学和将生命过程暴露数据整合到健康研究中的作用。讨论：实施暴露机制对于推进环境卫生和精准医疗领域至关重要。美国国立卫生研究院支持的倡议，以及国际合作，旨在标准化方法，开发工具，促进跨学科研究。处理暴露学的复杂性需要整合不同的数据集并促进全球协调，为改进人类健康成果的创新战略铺平道路。https://doi.org/10.1289/EHP15561。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

14.40

自引率

2.90%

发文量

388

审稿时长

6 months

期刊介绍： Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.