Environmental Health Perspectives最新文献

{"title":"Development of an Automated Morphometric Approach to Assess Vascular Outcomes following Exposure to Environmental Chemicals in Zebrafish.","authors":"Xiali Zhong, Junzhou Chen, Zhuyi Zhang, Qicheng Zhu, Di Ji, Weijian Ke, Congying Niu, Can Wang, Nan Zhao, Wenquan Chen, Kunkun Jia, Qian Liu, Maoyong Song, Chunqiao Liu, Yanhong Wei","doi":"10.1289/EHP13214","DOIUrl":"https://doi.org/10.1289/EHP13214","url":null,"abstract":"<p><strong>Background: </strong>Disruptions in vascular formation attributable to chemical insults is a pivotal risk factor or potential etiology of developmental defects and various disease settings. Among the thousands of chemicals threatening human health, the highly concerning groups prevalent in the environment and detected in biological monitoring in the general population ought to be prioritized because of their high exposure risks. However, the impacts of a large number of environmental chemicals on vasculature are far from understood. The angioarchitecture complexity and technical limitations make it challenging to analyze the entire vasculature efficiently and identify subtle changes through a high-throughput <i>in vivo</i> assay.</p><p><strong>Objectives: </strong>We aimed to develop an automated morphometric approach for the vascular profile and assess the vascular morphology of health-concerning environmental chemicals.</p><p><strong>Methods: </strong>High-resolution images of the entire vasculature in <i>Tg(fli1a:eGFP)</i> zebrafish were collected using a high-content imaging platform. We established a deep learning-based quantitative framework, ECA-ResXUnet, combined with MATLAB to segment the vascular networks and extract features. Vessel scores based on the rates of morphological changes were calculated to rank vascular toxicity. Potential biomarkers were identified by vessel-endothelium-gene-disease integrative analysis.</p><p><strong>Results: </strong>Whole-trunk blood vessels and the cerebral vasculature in larvae exposed to 150 representative chemicals were automatically segmented as comparable to human-level accuracy, with sensitivity and specificity of 95.56% and 95.81%, respectively. Chemical treatments led to heterogeneous vascular patterns manifested by 31 architecture indexes, and the common cardinal vein (CCV) was the most affected vessel. The antipsychotic medicine haloperidol, flame retardant 2,2-bis(chloromethyl)trimethylenebis[bis(2-chloroethyl) phosphate], and <i>tert</i>-butylphenyl diphenyl phosphate ranked as the top three in vessel scores. Pesticides accounted for the largest group, with a vessel score of <math><mrow><mo>≥</mo><mn>1</mn></mrow></math>, characterized by a remarkable inhibition of subintestinal venous plexus and delayed development of CCV. Multiple-concentration evaluation of nine per- and polyfluoroalkyl substances (PFAS) indicated a low-concentration effect on vascular impairment and a positive association between carbon chain length and benchmark concentration. Target vessel-directed single-cell RNA sequencing of <math><mrow><mi>f</mi><mi>l</mi><mi>i</mi><mn>1</mn><mrow><msup><mrow><mi>a</mi></mrow><mrow><mo>+</mo></mrow></msup></mrow></mrow></math> cells from larvae treated with <math><mrow><mi>λ</mi><mtext>-cyhalothrin</mtext></mrow></math>, perfluorohexanesulfonic acid, or benzylbutyl phthalate, along with vessel-endothelium-gene-disease integrative analysis, uncovered potential associatio","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"57001"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Toward Resilience-Community-Based Approaches to Managing Combined Sewer Overflows in a Changing Climate.","authors":"Jan C Semenza","doi":"10.1289/EHP15000","DOIUrl":"10.1289/EHP15000","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"51301"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Combined Sewer Overflow Events and Gastrointestinal Illness in Massachusetts Municipalities with and without River-Sourced Drinking Water, 2014-2019.","authors":"Beth M Haley, Yuantong Sun, Jyotsna S Jagai, Jessica H Leibler, Robinson Fulweiler, Jacqueline Ashmore, Gregory A Wellenius, Wendy Heiger-Bernays","doi":"10.1289/EHP14213","DOIUrl":"10.1289/EHP14213","url":null,"abstract":"<p><strong>Background: </strong>Combined sewer overflow (CSO) events release untreated wastewater into surface waterbodies during heavy precipitation and snowmelt. Combined sewer systems serve <math><mrow><mo>∼</mo><mn>40</mn><mtext> million</mtext></mrow></math> people in the United States, primarily in urban and suburban municipalities in the Midwest and Northeast. Predicted increases in heavy precipitation events driven by climate change underscore the importance of quantifying potential health risks associated with CSO events.</p><p><strong>Objectives: </strong>The aims of this study were to <i>a</i>) estimate the association between CSO events (2014-2019) and emergency department (ED) visits for acute gastrointestinal illness (AGI) among Massachusetts municipalities that border a CSO-impacted river, and <i>b</i>) determine whether associations differ by municipal drinking water source.</p><p><strong>Methods: </strong>A case time-series design was used to estimate the association between daily cumulative upstream CSO discharge and ED visits for AGI over lag periods of 4, 7, and 14 days, adjusting for temporal trends, temperature, and precipitation. Associations between CSO events and AGI were also compared by municipal drinking water source (CSO-impacted river vs. other sources).</p><p><strong>Results: </strong>Extreme upstream CSO discharge events (<math><mrow><mo>></mo><mn>95</mn></mrow></math>th percentile by cumulative volume) were associated with a cumulative risk ratio (CRR) of AGI of 1.22 [95% confidence interval (CI): 1.05, 1.42] over the next 4 days for all municipalities, and the association was robust after adjusting for precipitation [1.17 (95% CI: 0.98, 1.39)], although the CI includes the null. In municipalities with CSO-impacted drinking water sources, the adjusted association was somewhat less pronounced following 95th percentile CSO events [<math><mrow><mtext>CRR</mtext><mspace></mspace><mo>=</mo></mrow></math> 1.05 (95% CI: 0.82, 1.33)]. The adjusted CRR of AGI was 1.62 in all municipalities following 99th percentile CSO events (95% CI: 1.04, 2.51) and not statistically different when stratified by drinking water source.</p><p><strong>Discussion: </strong>In municipalities bordering a CSO-impacted river in Massachusetts, extreme CSO events are associated with higher risk of AGI within 4 days. The largest CSO events are associated with increased risk of AGI regardless of drinking water source. https://doi.org/10.1289/EHP14213.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"57008"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: \"Wake-up Call: Rapid Increase in Human Fungal Diseases under Climate Change\".","authors":"Lindsey Konkel Neabore","doi":"10.1289/EHP15250","DOIUrl":"10.1289/EHP15250","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"59001"},"PeriodicalIF":10.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Class Act? Regulating Organohalogen Flame Retardants in Groups versus Singly.","authors":"Nate Seltenrich","doi":"10.1289/EHP14881","DOIUrl":"https://doi.org/10.1289/EHP14881","url":null,"abstract":"<p><p>Regulating chemicals by class based on chemical similarities may help reduce risk of regrettable substitutions while enhancing health protection. A new Commentary summarizes OFR toxicity and exposure research to inform this effort.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"54002"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust.","authors":"Roger Atanga, Lidia L Appell, Myranda N Thompson, Fredine T Lauer, Adrian Brearley, Matthew J Campen, Eliseo F Castillo, Julie G In","doi":"10.1289/EHP13855","DOIUrl":"10.1289/EHP13855","url":null,"abstract":"<p><strong>Background: </strong>Uranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been described; however, transcriptomic changes within the intestinal epithelial cells and impacts on lineage differentiation are largely unknown.</p><p><strong>Objectives: </strong>Herein, we sought to determine the molecular and cellular changes that occur in the colon in response to uranium bearing dust (UBD) exposure.</p><p><strong>Methods: </strong>Human colonoids from three biologically distinct donors were acutely exposed to UBD then digested for single cell RNA sequencing to define the molecular changes that occur to specific identities of colonic epithelial cells. Validation in colonoids was assessed using morphological and imaging techniques.</p><p><strong>Results: </strong>Human colonoids acutely exposed to UBD exhibited disrupted proliferation and hyperplastic differentiation of the secretory lineage cell, enteroendocrine cells (EEC). Single-cell RNA sequencing also showed more EEC subtypes present in UBD-exposed colonoids.</p><p><strong>Discussion: </strong>These findings highlight the significance of crypt-based proliferative cells and secretory cell differentiation using human colonoids to model major colonic responses to uranium-bearing particulate dust exposure. https://doi.org/10.1289/EHP13855.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"57006"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11108582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.","authors":"Danielle E McBride, Amit Bhattacharya, Heidi Sucharew, Kelly J Brunst, Mary Barnas, Cyndy Cox, Lorenna Altman, Timothy J Hilbert, Jeff Burkle, Susan Westneat, Kaitlin Vollet Martin, Patrick J Parsons, Meredith L Praamsma, Christopher D Palmer, Kurunthachalam Kannan, Donald R Smith, Robert Wright, Chitra Amarasiriwardena, Kim N Dietrich, Kim M Cecil, Erin N Haynes","doi":"10.1289/EHP13381","DOIUrl":"10.1289/EHP13381","url":null,"abstract":"<p><strong>Background: </strong>Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance.</p><p><strong>Objectives: </strong>This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort.</p><p><strong>Methods: </strong>Participants were recruited into CARES when they were 7-9 y old, and reenrolled at 13-18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height-weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine.</p><p><strong>Results: </strong>CARES participants who completed the adolescent postural balance assessment (<math><mrow><mi>n</mi><mo>=</mo><mn>123</mn></mrow></math>) were 98% White and 54% female and had a mean age of 16 y (range: 13-18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males.</p><p><strong>Discussion: </strong>This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. https://doi.org/10.1289/EHP13381.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"57010"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal and Infancy Exposure to Phenols, Parabens, and Phthalates and Anthropometric Measurements up to 36 Months, in the Longitudinal SEPAGES Cohort.","authors":"Marion Ouidir, Aminata H Cissé, Jérémie Botton, Sarah Lyon-Caen, Cathrine Thomsen, Amrit K Sakhi, Azemira Sabaredzovic, Sam Bayat, Rémy Slama, Barbara Heude, Claire Philippat","doi":"10.1289/EHP13644","DOIUrl":"10.1289/EHP13644","url":null,"abstract":"<p><strong>Background: </strong>Endocrine-disrupting chemicals may play a role in adiposity development during childhood. Until now literature in this scope suffers from methodologic limitations in exposure assessment using one or few urine samples and missing assessment during the infancy period.</p><p><strong>Objectives: </strong>We investigated the associations between early-life exposure to quickly metabolized chemicals and post-natal growth, relying on repeated within-subject urine collections over pregnancy and infancy.</p><p><strong>Methods: </strong>We studied the associations of four phenols, four parabens, seven phthalates, and one nonphthalate plasticizer from weekly pooled urine samples collected from the mother during second and third trimesters (median 18 and 34 gestational weeks, respectively) and infant at 2 and 12 months of age, and child growth until 36 months. We relied on repeated measures of height, weight and head circumference from study visits and the child health booklet to predict growth outcomes at 3 and 36 months using the Jenss-Bayley nonlinear mixed model. We assessed associations with individual chemicals using adjusted linear regression and mixtures of chemicals using a Bayesian kernel machine regression model.</p><p><strong>Results: </strong>The unipollutant analysis revealed few associations. Bisphenol S (BPS) at second trimester was positively associated with all infant growth parameters at 3 and 36 months, with similar patterns between exposure at third trimester and all infant growth parameters at 3 months. Mono-<i>n</i>-butyl phthalate (MnBP) at 12 months was positively associated with body mass index (BMI), weight, and head circumference at 36 months. Mixture analysis revealed positive associations between exposure at 12 months and BMI and weight at 36 months, with MnBP showing the highest effect size within the mixture.</p><p><strong>Conclusions: </strong>This study suggests that exposure in early infancy may be associated with increased weight and BMI in early childhood, which are risk factors of obesity in later life. Furthermore, this study highlighted the impact of BPS, a compound replacing bisphenol A, which has never been studied in this context. https://doi.org/10.1289/EHP13644.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"57002"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Differences in Cohort Analyses of the Relationship between Secondhand Smoke Exposure during Pregnancy and Birth Weight: The Transportability Framework in the ECHO Program.","authors":"Andreas M Neophytou, Jenny Aalborg, Sheryl Magzamen, Brianna F Moore, Assiamira Ferrara, Margaret R Karagas, Leonardo Trasande, Dana Dabelea","doi":"10.1289/EHP13961","DOIUrl":"10.1289/EHP13961","url":null,"abstract":"<p><strong>Background: </strong>Estimates for the effects of environmental exposures on health outcomes, including secondhand smoke (SHS) exposure, often present considerable variability across studies. Knowledge of the reasons behind these differences can aid our understanding of effects in specific populations as well as inform practices of combining data from multiple studies.</p><p><strong>Objectives: </strong>This study aimed to assess the presence of effect modification by measured sociodemographic characteristics on the effect of SHS exposure during pregnancy on birth weights that may drive differences observed across cohorts. We also aimed to quantify the extent to which differences in the cohort mean effects observed across cohorts in the Environmental influences on Child Health Outcomes (ECHO) consortium are due to differing distributions of these characteristics.</p><p><strong>Methods: </strong>We assessed the presence of effect modification and transportability of effect estimates across five ECHO cohorts in a total of 6,771 mother-offspring dyads. We assessed the presence of effect modification via gradient boosting of regression trees based on the H-statistic. We estimated individual cohort effects using linear models and targeted maximum likelihood estimation (TMLE). We then estimated transported effects from one cohort to each of the remaining cohorts using a robust nonparametric estimation approach relying on TMLE estimators and compared them to the original effect estimates for these cohorts.</p><p><strong>Results: </strong>Observed effect estimates varied across the five cohorts, ranging from significantly lower birth weight associated with exposure [<math><mrow><mo>-</mo><mn>167.3</mn><mspace></mspace><mi>g</mi></mrow></math>; 95% confidence interval (CI): <math><mrow><mo>-</mo><mn>270.4</mn></mrow></math>, <math><mrow><mo>-</mo><mn>64.1</mn></mrow></math>] to higher birth weight with wide CIs, including the null (<math><mrow><mn>42.4</mn><mspace></mspace><mi>g</mi></mrow></math>; 95% CI: <math><mrow><mo>-</mo><mn>15.0</mn></mrow></math>, 99.8). Transported effect estimates only minimally explained differences in the point estimates for two out of the four cohort pairs.</p><p><strong>Discussion: </strong>Our findings of weak to moderate evidence of effect modification and transportability indicate that unmeasured individual-level and contextual factors and sources of bias may be responsible for differences in the effect estimates observed across ECHO cohorts. https://doi.org/10.1289/EHP13961.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"57007"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11108581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of the Heat-Related Risk and Burden of Hospitalizations for Cause-Specific Injuries and Contribution of Human-Induced Climate Change: A Time-Stratified Case-Crossover Study in China.","authors":"Lu Zhou, Cong Liu, Cheng He, Jian Lei, Yixiang Zhu, Ya Gao, Jianwei Xuan, Haidong Kan, Renjie Chen","doi":"10.1289/EHP14057","DOIUrl":"10.1289/EHP14057","url":null,"abstract":"<p><strong>Background: </strong>Although ambient temperature has been linked with injury incidence, there have been few nationwide studies to quantify the temperature-related risk and burden of cause-specific injury hospitalizations. Additionally, the impact of human-induced climate change to injury burden remains unknown.</p><p><strong>Objectives: </strong>Our objectives are to examine the associations between ambient temperature and injury hospitalizations from various causes and to quantify the contribution of human-induced warming to the heat-related burden.</p><p><strong>Methods: </strong>We collected injury hospitalization data from a nationwide hospital-based registry in China during 2000-2019. Using a time-stratified case-crossover design, we investigated the associations between daily mean temperature (°C) and cause-specific injury hospitalizations. We also quantified the burden of heat-related injuries under the scenarios with and without anthropogenic forcing, using the Detection and Attribution Model Intercomparison Project to assess the contribution of human-induced warming.</p><p><strong>Results: </strong>Our study included a total of 988,087 patients with hospitalization records for injuries. Overall, compared to the temperature at minimum risk of hospitalization (<math><mrow><mo>-</mo><mn>12.1</mn><mo>°</mo><mi>C</mi></mrow></math>), the relative risk of hospitalization at extreme hot temperature (30.8°C, 97.5th percentile) was 1.18 [95% confidence interval (CI): 1.14, 1.22], with an approximately linear association between temperature and hospitalization. Vulnerability to heat-related injuries was more pronounced among males, young (<math><mrow><mo><</mo><mn>18</mn></mrow></math> years of age) or middle-aged (45-64 years of age) individuals, and those living in the North. The heat-related attributable fraction increased from 23.2% in the 2000s to 23.6% in the 2010s, with a corresponding increase in the contribution of human-induced change over time. In the 2010s, the heat-related attributable fractions for specific causes of injury ranged from 12.4% to 54.4%, with human-induced change accounting for 6.7% to 10.6% of the burden.</p><p><strong>Discussion: </strong>This nationwide study presents new evidence of significant associations between temperature and cause-specific injury hospitalizations in China and highlights the increasing contribution of human-induced warming to the injury burden. https://doi.org/10.1289/EHP14057.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 5","pages":"57005"},"PeriodicalIF":10.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}