Environmental Health Perspectives最新文献

{"title":"Response to \"Comment on 'Exposure to Per- and Polyfluoroalkyl Substances and Mortality in US Adults: A Population-Based Cohort Study'\".","authors":"Xue Wen, Mei Wang, Xuewen Xu, Tao Li","doi":"10.1289/EHP17324","DOIUrl":"10.1289/EHP17324","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":"48003"},"PeriodicalIF":10.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.","authors":"Lisa A Vrooman, Mary C Gieske, Crystal Lawson, Joseph Cesare, Shuo Zhang, Marisa S Bartolomei, Benjamin A Garcia, Terry J Hassold, Patricia A Hunt","doi":"10.1289/EHP15046","DOIUrl":"10.1289/EHP15046","url":null,"abstract":"<p><strong>Background: </strong>Environmental contamination by endocrine-disrupting chemicals (EDCs) has created serious public health, ecological, and regulatory concerns. Prenatal exposures can affect a wide range of developing organ systems and are associated with adverse changes to behavior, metabolism, fertility, and disease risk in the adult. The most serious and puzzling observation for some EDC exposures is the transmission of effects to subsequent unexposed generations (transgenerational effects) in animal models. This requires the induction of epigenetic aberrations to the germline that are not subject to the normal processes of erasure and resetting in subsequent generations. Understanding when and how the germline is vulnerable to environmental contaminants is an essential first step in devising strategies to prevent and reverse their effects.</p><p><strong>Methods: </strong>Fetal mouse oocytes were collected after exposure of the dam to various concentrations of bisphenol A (BPA) or placebo. Meiotic effects were assessed by immunostaining to visualize the synaptonemal complex and recombination sites, as well as whole chromosome fluorescence <i>in situ</i> hybridization probes. Enriched oocyte pools were analyzed by mass spectrometry and RNA sequencing to determine differences in histone posttranslational modifications and gene expression, respectively.</p><p><strong>Results: </strong>We found germline effects across a wide range of exposure levels, the severity of which was positively associated with BPA concentration. We identified the onset of meiotic prophase as the vulnerable window of exposure and found surprising exposure-related differences in chromatin. Oocyte analysis by mass spectrometry and immunofluorescence suggested H4K20me2, a histone posttranslational modification involved in DNA damage repair, was particularly affected. Subsequent RNA-seq analysis revealed a relatively small number of differentially expressed genes, but in addition to genes involved in chromatin dynamics, several with important roles in DNA repair/recombination and centromere stability were affected.</p><p><strong>Discussion: </strong>Together, our data from a mouse model suggest BPA exposure induced complex molecular differences in the germline that dysregulated chromatin and affected several critical and interrelated meiotic pathways. https://doi.org/10.1289/EHP15046.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":"47002"},"PeriodicalIF":10.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<ArticleTitle xmlns:ns0=\"http://www.w3.org/1998/Math/MathML\">Estimating the Effects of Hypothetical Ambient <ns0:math><ns0:mrow><ns0:mi>P</ns0:mi><ns0:mrow><ns0:msub><ns0:mrow><ns0:mi>M</ns0:mi></ns0:mrow><ns0:mrow><ns0:mn>2.5</ns0:mn></ns0:mrow></ns0:msub></ns0:mrow></ns0:mrow></ns0:math> Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort.","authors":"Chengyi Lin, Riyang Liu, Caroline Sutton, Andrew T DeWan, Laura Forastiere, Kai Chen","doi":"10.1289/EHP14723","DOIUrl":"10.1289/EHP14723","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Emerging evidence identifies ambient particulate matter (PM) with an aerodynamic diameter &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;≤&lt;/mo&gt;&lt;mn&gt;2.5&lt;/mn&gt;&lt;mspace&gt;&lt;/mspace&gt;&lt;mi&gt;μ&lt;/mi&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt; (&lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mi&gt;PM&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;2.5&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;) as a modifiable risk factor for dementia, but the potential health benefits gained by enacting regulations that reduce &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mi&gt;PM&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;2.5&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt; remain unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Our aim was to estimate the total effects of hypothetical ambient &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mi&gt;PM&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;2.5&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt; interventions starting in late life on the risk of dementia in a cohort using the parametric g-formula.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We used data from 291,495 participants in the UK Biobank cohort who were free of dementia and &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;≥&lt;/mo&gt;&lt;mn&gt;55&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; y of age at baseline (2010). We estimated the total effects of hypothetical ambient &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mi&gt;PM&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;2.5&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt; interventions (achieving annual average standards of &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;12&lt;/mn&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mtext&gt; &lt;/mtext&gt;&lt;mi&gt;μ&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mn&gt;3&lt;/mn&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;10&lt;/mn&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mtext&gt; &lt;/mtext&gt;&lt;mi&gt;μ&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mn&gt;3&lt;/mn&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;, and &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;9&lt;/mn&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mtext&gt; &lt;/mtext&gt;&lt;mi&gt;μ&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mn&gt;3&lt;/mn&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;) from 2010 to 2019 on the risk of dementia by calculating the difference between the estimated 10-y risk of dementia under a specified hypothetical intervention and the risk under no intervention using the parametric g-formula.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In comparison with no intervention, the estimated 10-y risk difference of dementia was &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.54&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; per 1,000 population [95% confidence interval (CI): &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;1.00&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.10&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;], &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;1.36&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; per 1,000 population (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;2.44&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.25&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;), &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;1.92&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; per 1,000 population (95% CI: &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;3.39&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;, &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt;&lt;mn&gt;0.33&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;), with &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mi&gt;PM&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;2.5&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt; interventions achieving annual average standards of &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;12&lt;/mn&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;mtext&gt; &lt;/mtext&gt;&lt;mi&gt;μ&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;/mrow","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":"47007"},"PeriodicalIF":10.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal average temperature differences and CVD incidence: results from the US-based Nurses' Health study, Nurses' Health Study II, and the Health Professional Follow-up study.","authors":"Jochem O Klompmaker, Francine Laden, Francesca Dominici, Peter James, Eric Rimm, Charlie Roscoe, Grete Wilt, Antonella Zanobetti, Jaime E Hart","doi":"10.1289/EHP14677","DOIUrl":"https://doi.org/10.1289/EHP14677","url":null,"abstract":"<p><strong>Background: </strong>Climate change is one of the greatest health threats facing humanity. Multiple studies have documented the impact of short-term temperature exposure on human health. However, long-term temperature exposures are far less studied.</p><p><strong>Objectives: </strong>We examined whether exposure to higher or lower summer and winter average temperatures compared to long-term average temperatures were associated with cardiovascular disease (CVD) incidence in three US-based cohorts.</p><p><strong>Methods: </strong>We followed 276,618 participants from the Nurses' Health Study (NHS, 1991-2018), the NHSII (1994-2017), and the Health Professionals' Follow-Up Study (1991-2015). We used data (1986-2018) from PRISM Spatial Climate Datasets (800 × 800m spatial resolution) to calculate differences between the summer (June-August) and winter (December-February) average temperatures and the previous 5-year summer and winter average temperatures at residential addresses of each participant. CVD incidence was defined as first nonfatal or fatal MI or nonfatal or fatal stroke. Cox proportional hazard models were used to examine associations with between average temperatures and CVD incidence. Hazard ratios (HRs) and 95% confidence intervals (95%CI) were pooled using random effect meta-analysis. We also examined associations in the populations aged <65 and 65+ years.</p><p><strong>Results: </strong>After pooling HRs, we found no association of summer average temperatures higher than the previous 5-year average temperature, with CVD incidence. A winter average temperature lower than the previous 5-year average was associated with CVD incidence (HR = 0.96 per 2.7°C increase, 95%CI: 0.94, 0.98). Among persons aged <65 years, we observed increased CVD risks with higher summer average temperatures (pooled HR = 1.03 per 1.3°C increase, 95%CI: 1.00, 1.07) and lower winter average temperatures (pooled HR = 0.91 per 2.7°C increase, 95%CI: 0.87, 0.94) compared to the previous 5-year average temperature.</p><p><strong>Discussion: </strong>Exposure to a winter average temperature lower than the previous 5-year average was associated with an increased CVD risk. Exposure to a summer average temperature higher than the previous 5-year average was associated with CVD incidence in the population aged <65 years, but not in the full population. https://doi.org/10.1289/EHP14677.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to synthetic phenols assessed in multiple urine samples and dysregulation of steroid hormone homeostasis in two European cohorts.","authors":"Paulina Jedynak, Mariona Bustamante, Matthieu Rolland, Vicente Mustieles, Cathrine Thomsen, Amrit K Sakhi, Azemira Sabaredzovic, Maria Foraster, Mireia Gascon, Maria Dolores Gómez-Roig, Elisa Llurba, Ioar Rivas, Isabelle Ouellet-Morin, Sam Bayat, Sarah Lyon-Caen, Oscar J Pozo, Martine Vrijheid, Jordi Sunyer, Rémy Slama, Payam Dadvand, Claire Philippat","doi":"10.1289/EHP15117","DOIUrl":"https://doi.org/10.1289/EHP15117","url":null,"abstract":"<p><strong>Background: </strong>Some synthetic phenols alter hormonal pathways involved in successful pregnancy and fetal development. Despite high within-subject temporal variability of phenols, previous studies mostly utilized spot urine samples to assess pregnancy exposure. Herein we investigated associations between pregnancy exposure to eight phenols assessed in multiple pooled urine samples and steroid hormones assessed in maternal hair reflecting cumulative hormone levels over the previous weeks to months.</p><p><strong>Methods: </strong>We assessed phenol-hormone associations in 928 pregnant women from two pooled cohorts recruited in Spain (BiSC, 2018-2021) and France (SEPAGES, 2014-2017), using pools of up to 21 samples each, collected in early pregnancy (median gestational age: 18.0 weeks), as well as hair collected in late pregnancy (BiSC) or at birth (SEPAGES). We measured two bisphenols, four parabens, benzophenone-3, and triclosan along with metabolites of three adrenal (Σcortisol, Σcortisone, 11-dehydrocorticosterone) and two reproductive hormones (progesterone, testosterone). We ran adjusted linear regressions for each exposure-outcome pair and Bayesian Kernel Machine Regression for phenols mixture.</p><p><strong>Results: </strong>Bisphenol S was associated with higher cortisol and 11-dehydrocorticosterone concentrations. Propylparaben was associated with lower levels of cortisol, cortisone, and 11-dehydrocorticosterone, while methylparaben was linked to a reduction in cortisol levels. Interestingly, associations identified for parabens were stronger for women carrying female fetuses. No associations for phenols mixture were detected.</p><p><strong>Conclusions: </strong>Our study suggests that pregnancy exposure to bisphenol S and some parabens (propyl- and methylparaben) may affect production of maternal corticosteroid hormones that are important for a successful pregnancy and fetal development.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Comment on 'Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis'\".","authors":"Wenxin Wan, Susan Peters, Lützen Portengen, Ronnie Babigumira, Jo Steinson Stenehjem, David Richardson, Roel Vermeulen","doi":"10.1289/EHP17293","DOIUrl":"https://doi.org/10.1289/EHP17293","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis\".","authors":"Jian Huang","doi":"10.1289/EHP17036","DOIUrl":"https://doi.org/10.1289/EHP17036","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Prenatal and childhood exposure to fluoride and cognitive development: findings from the longitudinal MINIMat cohort in rural Bangladesh.","authors":"Christine Till","doi":"10.1289/EHP16269","DOIUrl":"https://doi.org/10.1289/EHP16269","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Cohort Perspective of Climate Epidemiology: The Case of Examining Intergenerational Inequalities in Susceptibility to Non-Optimal Temperatures in Japan.","authors":"Lei Yuan, Yasushi Honda, Lina Madaniyazi, Aurelio Tobias, Chris Fook Sheng Ng, Masahiro Hashizume","doi":"10.1289/EHP15226","DOIUrl":"10.1289/EHP15226","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Younger generations are projected to experience more severe climate exposure impacts during their lifetimes than older generations as global warming progresses. Despite the increasing evidence of the recent temporal changes in heat-related mortality risks, there remains a lack of research exploring this association from a cohort perspective.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Our objective was to quantify the variation in susceptibility to short-term effects of non-optimal temperature on mortality, across generations and over the life course of specific generations, using a novel age-period-cohort approach.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An extended two-stage analytical approach was applied to a nationwide mortality dataset covering individuals born from 1866 to 2019 in all 47 prefectures in Japan. Daily mortality counts observed between 1972 and 2019 were aggregated into 5-year birth cohorts and corresponding age groups of the decedents. For each prefecture and birth cohort, the age-dependent association between ambient temperature and daily mortality was modeled using conditional quasi-Poisson regression. Then, the prefecture-specific associations were pooled across cohorts, separately for each age group, using a repeated-measure meta-regression. To model the intergenerational changes in risks, a nonlinear, continuous term for cohort was applied in the meta-analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 29 million all-cause deaths were analyzed. The relative risk (RR) of heat-related mortality (99th temperature percentile compared to minimum mortality temperature) decreased across generations for elder adults (65-89 years of age), from &lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;RR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1.18&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; [95% confidence interval (CI): 1.13, 1.23] for those born in 1901-1905 to &lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;RR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;1.04&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; (95% CI: 1.01, 1.07) for those born in 1926-1930 (&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mtext&gt;-trend&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.004&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;). Similar to heat-related risk, the cold-related mortality risk (at first percentile) also decreased across the same cohorts (&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mtext&gt;-trend&lt;/mtext&gt;&lt;mo&gt;&lt;&lt;/mo&gt;&lt;mn&gt;0.001&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;). The predicted continuous trends in heat- and cold-related mortality risks exhibited a nonlinear decline across generations. An inconsistent pattern was observed for middle-aged people (40-64 years of age) born between 1930 and 1960, with a slight increase in risks for cold and heat over generations. For cohort-specific risk trajectories, heat- and cold-related mortality risks generally increased with age, after 60 years old.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This nationwide, individual-level study adopted a novel cohort perspective to investigate how population susceptibility to short-term non-optimal temperature exposure varies across generations. Our findings revealed disparities in susceptibility between generations, highlighting th","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 2","pages":"27003"},"PeriodicalIF":10.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Understanding the Links between Weather and Environmental Health to Strengthen Climate Resilience.","authors":"Katrina J Charles","doi":"10.1289/EHP16766","DOIUrl":"10.1289/EHP16766","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"133 2","pages":"21301"},"PeriodicalIF":10.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}