Environmental Health Perspectives最新文献

{"title":"After the Smoke Clears: Wildland-Urban Interface Fires and Residues in Nearby Homes.","authors":"Nancy Averett","doi":"10.1289/EHP14770","DOIUrl":"10.1289/EHP14770","url":null,"abstract":"<p><p>Scientists are scrambling to fill major research gaps about the types of pollutants released when wildfires burn not just vegetation, but also structures and vehicles-and how nearby residents can protect themselves.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 7","pages":"72001"},"PeriodicalIF":10.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Airway Microbiome and the Immune Response to Diesel Exhaust: A Randomized Crossover Controlled Exposure Study.","authors":"Min Hyung Ryu, Illiassou Hamidou Soumana, Denise J Wooding, Fernando Sergio Leitao Filho, Julia Yang, Corey Nislow, Christopher F Rider, Janice M Leung, Chris Carlsten","doi":"10.1289/EHP13874","DOIUrl":"10.1289/EHP13874","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 7","pages":"77701"},"PeriodicalIF":10.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS).","authors":"Sebastian Gutsfeld, Leah Wehmas, Ifeoluwa Omoyeni, Nicole Schweiger, David Leuthold, Paul Michaelis, Xia Meng Howey, Shaza Gaballah, Nadia Herold, Carolina Vogs, Carmen Wood, Luísa Bertotto, Gi-Mick Wu, Nils Klüver, Wibke Busch, Stefan Scholz, Jana Schor, Tamara Tal","doi":"10.1289/EHP13667","DOIUrl":"10.1289/EHP13667","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl Substances (PFAS) are synthetic chemicals widely detected in humans and the environment. Exposure to perfluorooctanesulfonic acid (PFOS) or perfluorohexanesulfonic acid (PFHxS) was previously shown to cause dark-phase hyperactivity in larval zebrafish.</p><p><strong>Objectives: </strong>The objective of this study was to elucidate the mechanism by which PFOS or PFHxS exposure caused hyperactivity in larval zebrafish.</p><p><strong>Methods: </strong>Swimming behavior was assessed in 5-d postfertilization (dpf) larvae following developmental (1-4 dpf) or acute (5 dpf) exposure to <math><mrow><mn>0.43</mn><mo>-</mo><mn>7.86</mn><mspace></mspace><mi>μ</mi><mi>M</mi></mrow></math> PFOS, <math><mrow><mn>7.87</mn><mo>-</mo><mn>120</mn><mspace></mspace><mi>μ</mi><mi>M</mi></mrow></math> PFHxS, or 0.4% dimethyl sulfoxide (DMSO). After developmental exposure and chemical washout at 4 dpf, behavior was also assessed at 5-8 dpf. RNA sequencing was used to identify differences in global gene expression to perform transcriptomic benchmark concentration-response (<math><mrow><mrow><msub><mrow><mtext>BMC</mtext></mrow><mrow><mi>T</mi></mrow></msub></mrow></mrow></math>) modeling, and predict upstream regulators in PFOS- or PFHxS-exposed larvae. CRISPR/Cas9-based gene editing was used to knockdown peroxisome proliferator-activated receptors (ppars) <i>pparaa/ab</i>, <i>pparda/db</i>, or <i>pparg</i> at day 0. Knockdown crispants were exposed to <math><mrow><mn>7.86</mn><mspace></mspace><mi>μ</mi><mi>M</mi></mrow></math> PFOS or 0.4% DMSO from 1-4 dpf and behavior was assessed at 5 dpf. Coexposure with the ppard antagonist GSK3787 and PFOS was also performed.</p><p><strong>Results: </strong>Transient dark-phase hyperactivity occurred following developmental or acute exposure to PFOS or PFHxS, relative to the DMSO control. In contrast, visual startle response (VSR) hyperactivity only occurred following developmental exposure and was irreversible up to 8 dpf. Similar global transcriptomic profiles, <math><mrow><mrow><msub><mrow><mtext>BMC</mtext></mrow><mrow><mi>T</mi></mrow></msub></mrow></mrow></math> estimates, and enriched functions were observed in PFOS- and PFHxS-exposed larvae, and ppars were identified as putative upstream regulators. Knockdown of <i>pparda/db</i>, but not <i>pparaa/ab</i> or <i>pparg</i>, blunted PFOS-dependent VSR hyperactivity to control levels. This finding was confirmed via antagonism of <i>ppard</i> in PFOS-exposed larvae.</p><p><strong>Discussion: </strong>This work identifies a novel adverse outcome pathway for VSR hyperactivity in larval zebrafish. We demonstrate that developmental, but not acute, exposure to PFOS triggered persistent VSR hyperactivity that required <i>ppard</i> function. https://doi.org/10.1289/EHP13667.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 7","pages":"77007"},"PeriodicalIF":10.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60-69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study.","authors":"Peijie Sun, Xiaojie Guo, Enmin Ding, Chenfeng Li, Huimin Ren, Yibo Xu, Jiankun Qian, Fuchang Deng, Wanying Shi, Haoran Dong, Elizabeth Z Lin, Pengfei Guo, Jianlong Fang, Qian Zhang, Wenhua Zhao, Shilu Tong, Xiaobo Lu, Krystal J Godri Pollitt, Xiaoming Shi, Song Tang","doi":"10.1289/EHP13865","DOIUrl":"10.1289/EHP13865","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggested that abiotic airborne exposures may be associated with changes in body composition. However, more evidence is needed to identify key pollutants linked to adverse health effects and their underlying biomolecular mechanisms, particularly in sensitive older adults.</p><p><strong>Objectives: </strong>Our research aimed to systematically assess the relationship between abiotic airborne exposures and changes in body composition among healthy older adults, as well as the potential mediating mechanisms through the serum lipidome.</p><p><strong>Methods: </strong>From September 2018 to January 2019, we conducted a monthly survey among 76 healthy adults (60-69 years old) in the China Biomarkers of Air Pollutant Exposure (BAPE) study, measuring their personal exposures to 632 abiotic airborne pollutions using MicroPEM and the Fresh Air wristband, 18 body composition indicators from the InBody 770 device, and lipidomics from venous blood samples. We used an exposome-wide association study (ExWAS) and deletion/substitution/addition (DSA) model to unravel complex associations between exposure to contaminant mixtures and body composition, a Bayesian kernel machine regression (BKMR) model to assess the overall effect of key exposures on body composition, and mediation analysis to identify lipid intermediators.</p><p><strong>Results: </strong>The ExWAS and DSA model identified that 2,4,5-T methyl ester (2,4,5-TME), 9,10-Anthracenedione (ATQ), 4b,8-dimethyl-2-isopropylphenanthrene, and 4b,5,6,7,8,8a,9,10-octahydro-(DMIP) were associated with increased body fat mass (BFM), fat mass indicators (FMI), percent body fat (PBF), and visceral fat area (VFA) in healthy older adults [Bonferroni-Hochberg false discovery rate <math><mrow><mo>(</mo><mi>FD</mi><mrow><mrow><msub><mi>R</mi><mrow><mi>BH</mi></mrow></msub></mrow></mrow><mo>)</mo><mo><</mo><mn>0.05</mn></mrow></math>]. The BKMR model demonstrated a positive correlation between contaminants (anthracene, ATQ, copaene, di-epi-<math><mi>α</mi></math>-cedrene, and DMIP) with VFA. Mediation analysis revealed that phosphatidylcholine [PC, PC(16:1e/18:1), PC(16:2e/18:0)] and sphingolipid [SM, SM(d18:2/24:1)] mediated a significant portion, ranging from 12.27% to 26.03% (<i>p</i>-value <math><mrow><mo><</mo><mn>0.05</mn></mrow></math>), of the observed increase in VFA.</p><p><strong>Discussion: </strong>Based on the evidence from multiple model results, ATQ and DMIP were statistically significantly associated with the increased VFA levels of healthy older adults, potentially regulated through lipid intermediators. These findings may have important implications for identifying potentially harmful environmental chemicals and developing targeted strategies for the control and prevention of chronic diseases in the future, particularly as the global population is rapidly aging. https://doi.org/10.1289/EHP13865.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 7","pages":"77005"},"PeriodicalIF":10.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: More Greenspace, Less Cognitive Decline? Current Evidence and Future Directions.","authors":"Li-Xin Hu, Bo-Yi Yang","doi":"10.1289/EHP14915","DOIUrl":"10.1289/EHP14915","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 7","pages":"71302"},"PeriodicalIF":10.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes.","authors":"Madeleine H Milne, Paul A Helm, Keenan Munno, Satyendra P Bhavsar, Chelsea M Rochman","doi":"10.1289/EHP13540","DOIUrl":"10.1289/EHP13540","url":null,"abstract":"<p><strong>Background: </strong>Microplastics are a pervasive contaminant cycling through food webs-leading to concerns regarding exposure and risk to humans.</p><p><strong>Objectives: </strong>We aimed to quantify and characterize anthropogenic particle contamination (including microplastics) in fish caught for human consumption from the Humber Bay region of Lake Ontario. We related quantities of anthropogenic particles to other factors (e.g., fish size) that may help in understanding accumulation of microplastics in fish.</p><p><strong>Methods: </strong>A total of 45 samples of six fish species collected from Humber Bay in Lake Ontario near Toronto, Ontario, Canada, were examined for anthropogenic particles in their gastrointestinal (GI) tracts and fillets. Using microscopy and spectroscopy, suspected anthropogenic particles were identified and characterized.</p><p><strong>Results: </strong>We observed anthropogenic particles in the GI tracts and fillets of all species. Individual fish had a <math><mrow><mtext>mean</mtext><mo>±</mo><mtext>standard deviation</mtext></mrow></math> of <math><mrow><mn>138</mn><mo>±</mo><mn>231</mn></mrow></math> anthropogenic particles, with a single fish containing up to 1,508 particles. GI tracts had <math><mrow><mn>93</mn><mo>±</mo><mn>226</mn></mrow></math> particles/fish (<math><mrow><mn>9.8</mn><mo>±</mo><mn>32.6</mn></mrow></math> particles/gram), and fillets had <math><mrow><mn>56</mn><mo>±</mo><mn>61</mn></mrow></math> particles/fish (<math><mrow><mn>0.5</mn><mo>±</mo><mn>0.8</mn></mrow></math> particles/gram). Based on a consumption rate of 2 servings/week, the average yearly human exposure through the consumption of these fish fillets would be <math><mrow><mn>12,800</mn><mo>±</mo><mn>18,300</mn></mrow></math> particles.</p><p><strong>Discussion: </strong>Our findings suggest that consumption of recreationally caught freshwater fish can be a pathway for human exposure to microplastics. The elevated number of particles observed in fish from Humber Bay highlights the need for large-scale geographic monitoring, especially near sources of microplastics. Currently, it is unclear what the effects of ingesting microplastics are for humans, but given that recreationally caught freshwater fish are one pathway for human exposure, these data can be incorporated into future human health risk assessment frameworks for microplastics. https://doi.org/10.1289/EHP13540.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 7","pages":"77004"},"PeriodicalIF":10.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forever Pesticides: A Growing Source of PFAS Contamination in the Environment.","authors":"Nathan Donley, Caroline Cox, Kyla Bennett, Alexis M Temkin, David Q Andrews, Olga V Naidenko","doi":"10.1289/EHP13954","DOIUrl":"10.1289/EHP13954","url":null,"abstract":"<p><strong>Background: </strong>Environmental contamination by fluorinated chemicals, in particular chemicals from the per- and polyfluoroalkyl substances (PFAS) class, has raised concerns around the globe because of documented adverse impacts on human health, wildlife, and ecosystem quality. Recent studies have indicated that pesticide products may contain a variety of chemicals that meet the PFAS definition, including the active pesticide ingredients themselves. Given that pesticides are some of the most widely distributed pollutants across the world, the legacy impacts of PFAS addition into pesticide products could be widespread and have wide-ranging implications on agriculture and food and water contamination, as well as the presence of PFAS in rural environments.</p><p><strong>Objectives: </strong>The purpose of this commentary is to explore different ways that PFAS can be introduced into pesticide products, the extent of PFAS contamination of pesticide products, and the implications this could have for human and environmental health.</p><p><strong>Methods: </strong>We submitted multiple public records requests to state and federal agencies in the United States and Canada and extracted relevant data from those records. We also compiled data from publicly accessible databases for our analyses.</p><p><strong>Discussion: </strong>We found that the biggest contributor to PFAS in pesticide products was active ingredients and their degradates. Nearly a quarter of all US conventional pesticide active ingredients were organofluorines and 14% were PFAS, and for active ingredients approved in the last 10 y, this had increased to 61% organofluorines and 30% PFAS. Another major contributing source was through PFAS leaching from fluorinated containers into pesticide products. Fluorination of adjuvant products and \"inert\" ingredients appeared to be limited, although this represents a major knowledge gap. We explored aspects of immunotoxicity, persistence, water contamination, and total fluorine load in the environment and conclude that the recent trend of using fluorinated active ingredients in pesticides may be having effects on chemical toxicity and persistence that are not given adequate oversight in the United States. We recommend a more stringent risk assessment approach for fluorinated pesticides, transparent disclosure of \"inert\" ingredients on pesticide labels, a complete phase-out of post-mold fluorination of plastic containers, and greater monitoring in the United States. https://doi.org/10.1289/EHP13954.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 7","pages":"75003"},"PeriodicalIF":10.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Residential Greenness Exposure with Depression Incidence in Adults 50 Years of Age and Older: Findings from the Cohort Study on Global AGEing and Adult Health (SAGE) in China.","authors":"Zhiqing Chen, Fan Wu, Yan Shi, Yanfei Guo, Jiahong Xu, Shuru Liang, Zhongguo Huang, Guanhao He, Jianxiong Hu, Qijiong Zhu, Siwen Yu, Shangfeng Yang, Cuiling Wu, Weiling Tang, Xiaomei Dong, Wenjun Ma, Tao Liu","doi":"10.1289/EHP13947","DOIUrl":"10.1289/EHP13947","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Depression is a social and public health problem of great concern globally. Identifying and managing the factors influencing depression are crucial for preventing and decreasing the burden of depression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Our objectives are to explore the association between residential greenness and the incidence of depression in an older Chinese population and to calculate the disease burden of depression prevented by greenness exposure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study was the Chinese part of the World Health Organization Study on Global AGEing and Adult Health (WHO SAGE). We collected the data of 8,481 residents &lt;math&gt;&lt;mrow&gt;&lt;mo&gt;≥&lt;/mo&gt;&lt;mn&gt;50&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt; years of age in China for the period 2007-2018. Average follow-up duration was 7.00 (&lt;math&gt;&lt;mrow&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;mn&gt;2.51&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;) years. Each participant was matched to the yearly maximum normalized difference vegetation index (NDVI) at their residential address. Incidence of depression was assessed using the Composite International Diagnostic Interview (CIDI), self-reports of depression, and/or taking depression medication. Association between greenness and depression was examined using the time-dependent Cox regression model with stratified analysis by sex, age, urbanicity, annual family income, region, smoking, drinking, and household cooking fuels. Furthermore, the prevented fraction (PF) and attributable number (AN) of depression prevented by exposure to greenness were estimated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Residential greenness was negatively associated with depression. Each interquartile range (IQR) increase in NDVI &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;500&lt;/mn&gt;&lt;mtext&gt;-m&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt; buffer was associated with a 40% decrease [&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;hazard ratio &lt;/mtext&gt;&lt;mo&gt;(&lt;/mo&gt;&lt;mtext&gt;HR&lt;/mtext&gt;&lt;mo&gt;)&lt;/mo&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.60&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% confidence interval (CI): 0.37, 0.97] in the risk of depression incidence among the total participants. Subgroup analyses showed negative associations in urban residents (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;HR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.32&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 0.12, 0.86) vs. rural residents, in high-income residents (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;HR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.28&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 0.11, 0.71) vs. low-income residents, and in southern China (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;HR&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.50&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 0.26, 0.95) vs. northern China. Over 8.0% (&lt;math&gt;&lt;mrow&gt;&lt;mtext&gt;PF&lt;/mtext&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;8.69&lt;/mn&gt;&lt;mo&gt;%&lt;/mo&gt;&lt;/mrow&gt;&lt;/math&gt;; 95% CI: 1.38%, 15.40%) and 1,955,199 (95% CI: 310,492; 3,464,909) new cases of depression may be avoided by increasing greenness exposures annually across China.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The findings suggest protective effects of residential greenness exposure on depression incidence in the older population, particularly among urban residents, high-income residents, and participants living in southern China. The construction of residential greenness","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 6","pages":"67004"},"PeriodicalIF":10.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Psychiatric Emergency Visits and Warm Ambient Temperature during Pregnancy: A Time-Stratified Case-Crossover Study.","authors":"Jennifer D Runkle, Margaret M Sugg, Anne Berry, Charlie Reed, Kristen Cowan, Luke Wertis, Sophie Ryan","doi":"10.1289/EHP13293","DOIUrl":"10.1289/EHP13293","url":null,"abstract":"<p><strong>Background: </strong>Acute exposure to high ambient temperature and heat waves during the warm season has been linked with psychiatric disorders. Emerging research has shown that pregnant people, due to physiological and psychological changes, may be more sensitive to extreme heat, and acute exposure has been linked to increased risk of pregnancy complications; however, few studies have examined psychiatric complications.</p><p><strong>Objective: </strong>Our objective was to examine the association between acute exposure to warm ambient temperatures and emergency department (ED) visits for mental disorders during pregnancy.</p><p><strong>Methods: </strong>A time-stratified case-crossover design with conditional logistic regression was performed on <math><mrow><mo>∼</mo><mn>206,000</mn></mrow></math> psychiatric ED visits for pregnant patients in North Carolina, from May to September 2016 to 2019. Daily average ambient temperature was the main exposure and was linked to daily visits by maternal zip code of residence for prenatal mood and anxiety disorders (PMAD), severe mental illness (SMI), mental disorder of pregnancy (MDP), suicidal thoughts (SUIC), and any psychiatric disorder (Any). Effect modification by trimester, residential segregation, economic segregation, urbanicity, and availability of greenspace was also investigated.</p><p><strong>Results: </strong>Each <math><mrow><mn>5</mn><mo>°</mo><mi>C</mi></mrow></math> increase in same-day exposure to warm ambient temperature on case days was associated with an increase in incidence rate ratio (IRR) for any psychiatric disorder [IRR = 1.07; 95% confidence interval (CI): 1.01, 1.14] including anxiety (IRR = 1.14; 95% CI: 1.00, 1.30), bipolar disorder (IRR = 1.28; 95% CI: 0.98, 1.67), and suicidal thoughts (IRR = 1.28; 95% CI: 1.00, 1.65) compared to control days. In general, the associations were strongest for warm season temperatures on the same day of exposure or for temperatures averaged over the 3 or 6 d preceding the ED visit. The greatest risk of an incident ED admission for PMAD (RR = 1.20; 95% CI: 1.04, 1.39), particularly for anxiety (RR = 1.30; 95% CI: 1.07, 1.59), and any psychiatric disorder (RR = 1.17; 95% CI: 1.07, 1.28) occurred following cumulative exposure to hot temperatures the week before admission. Higher psychiatric burden from temperature was observed in urban areas and on extreme heat days.</p><p><strong>Conclusions: </strong>For this pregnant population in the southeastern United States, short-term exposure to high ambient temperatures during the warm season was associated with a greater risk of ED visits for an array of psychiatric disorders. Findings show that climate-related increases in ambient temperature may contribute to psychiatric morbidity in pregnant people. https://doi.org/10.1289/EHP13293.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 6","pages":"67001"},"PeriodicalIF":10.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: New Insight into Cadmium-Related Osteoporosis Yields Hope for Prevention and Therapy.","authors":"Lu Cai","doi":"10.1289/EHP15263","DOIUrl":"10.1289/EHP15263","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 6","pages":"61301"},"PeriodicalIF":10.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}