2008 - 2018年新发和遗留的全氟烷基和多氟烷基物质血清水平的趋势:一项在中国进行的纵向研究。

IF 10.1 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Xu Cheng, Yu Wang, Jin Zhang, Hong Guo, Lin Liu, Lu Liu, Junya Gao, Meian He
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引用次数: 0

摘要

背景:中国是全氟烷基和多氟烷基物质(PFAS)的重要生产国和消费国,但对中国人PFAS的纵向趋势了解有限。目的:本研究调查了中国人群中PFAS的年代际变化趋势和潜在暴露源,并探讨了潜在的误分类偏差。方法:对2008年、2013年和2018年采集的216名湖北省居民648份血清PFAS(含11种全氟羧酸(PFCAs)、9种全氟磺酸(PFSAs)、6种PFAS前体和4种PFAS替代品)进行重复测定。我们使用线性混合效应模型来检验PFAS浓度随调查时间的变化趋势。我们还使用主成分分析-多元线性回归(PCA-MLR)模型评估了PFAS的潜在暴露源。结果:在至少80%的人群中检测到11种PFAS, PFOS、PFOA和6:2CL-PFESA是主要的PFAS。我们发现线性全氟辛烷磺酸在10年期间略有下降;与此同时,PFOA的含量增加了一倍,短链PFCAs (PFBA、PFHpA)的检出率上升。6:2CL-PFESA(中国特定的PFAS替代品)保持了十年的高水平。在三个时间点观察到PFAS之间类似的相关趋势。我们的研究结果与其他研究结果的比较表明,研究人群暴露于三种潜在的污染源,可能是摄入受污染的饮食,大气中PFAS的远距离迁移,以及从灰尘、饮用水和日常用品中获得的暴露。我们发现某一时间点的血清PFAS测量值与5年的水平相似,但与10年的水平不同。讨论:我们的研究提供了中国退休工人在Dongfeng-Tongji队列中血清PFAS水平的信息,并强调暴露于新型PFCAs和PFAS替代品的风险值得继续关注。对于长期随访(如超过5年)的纵向研究,仅依赖单一基线血清PFAS水平可能产生误分类偏倚,导致预期的零偏倚,并影响对健康影响的估计。https://doi.org/10.1289/EHP15340。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trends in serum levels of emerging and legacy per- and polyfluoroalkyl substances from 2008 to 2018: a longitudinal study in China.

Background: China is an important producer and consumer of per- and polyfluoroalkyl substances (PFAS), but there is limited understanding of longitudinal trends of PFAS in Chinese people.

Objectives: This study investigated decadal trends in PFAS and potential sources of exposure in the Dongfeng-Tongji cohort of Chinese people and explored potential misclassification bias.

Methods: We repeatedly measured serum PFAS (containing 11 perfluorocarboxylic acids (PFCAs), 9 perfluorosulfonic acids (PFSAs), 6 PFAS precursors, and 4 PFAS alternatives) in 648 samples (collected in 2008, 2013, and 2018) from 216 Chinese residents in Hubei Province. We used linear mixed effect model to examine trends in PFAS concentrations over survey time. We also assessed the potential exposure sources of PFAS using principal component analysis-multiple linear regression (PCA-MLR) model.

Results: Eleven PFAS were detected in at least 80% of the population, PFOS, PFOA, and 6:2CL-PFESA being the predominant PFAS. We found a slight decrease in linear-PFOS during the 10-year period; at the same time, the levels of PFOA doubled and the detection rate of short-chain PFCAs (PFBA, PFHpA) rose. 6:2CL-PFESA (China specific PFAS alternative) remained high for a decade. Similar correlation trends between PFAS were observed at three timepoints. Comparison of our findings with those from other studies suggests the study population was exposed to three potential sources of contamination, which may represent ingestion of contaminated diets, long-range transport of atmospheric PFAS, and exposures acquired from dust, drinking water, and daily commodities. We found that serum PFAS measurement at on timepoint was similar to levels over a 5-year period but not a 10-year period.

Discussion: Our study provides information on serum PFAS levels in Chinese retired workers in the Dongfeng-Tongji cohort, and highlights that the risk of exposure to novel PFCAs and PFAS alternatives deserves continued attention. For longitudinal studies with long-term follow-up (e.g. more than 5 years), relying only on a single baseline serum PFAS level may generate misclassification bias resulting in expected bias towards the null and affect the estimation of health effects. https://doi.org/10.1289/EHP15340.

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来源期刊
Environmental Health Perspectives
Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
14.40
自引率
2.90%
发文量
388
审稿时长
6 months
期刊介绍: Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.
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