Hui-Chen Wu, Ronald A Glabonjat, Kathrin Schilling, William A Anderson, Siyue Gao, Arce Domingo Relloso, Nancy LoIacono, Monique Slowly, Anne E Nigra, Tiffany Sanchez, Marisa H Sobel, Marta Galvez-Fernandez, Matthew J Budoff, Mary V Gamble, Ana Navas-Acien, Mariana Lazo
{"title":"砷暴露和代谢生物标志物与肝脏疾病亚临床指标的关联：动脉粥样硬化多种族研究的横断面调查","authors":"Hui-Chen Wu, Ronald A Glabonjat, Kathrin Schilling, William A Anderson, Siyue Gao, Arce Domingo Relloso, Nancy LoIacono, Monique Slowly, Anne E Nigra, Tiffany Sanchez, Marisa H Sobel, Marta Galvez-Fernandez, Matthew J Budoff, Mary V Gamble, Ana Navas-Acien, Mariana Lazo","doi":"10.1289/EHP16728","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Long-term exposure to arsenic (As) can cause many health effects and As metabolism is key in the detoxification and elimination of As. We hypothesize that hepatic steatosis might affect As metabolism efficiency. We evaluated the association of As exposure and As metabolism biomarkers with hepatic steatosis.</p><p><strong>Methods: </strong>In this cross-sectional analysis, we analyzed data from 3,577 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), an ethnically diverse US adult population, with urinary metals and liver CT scan data available. We measured total As and As species in urine, and summarized As methylation biomarkers as inorganic (iAs%), monomethylarsonic acid (MMA%), and dimethylarsinic acid (DMA%). The ratio of liver-to-spleen (L/S) Hounsfield units (HU) < 1.0 and liver attenuation < 40 HU were used to assess the presence and severity of liver fat content. We used logistic regression to estimate the odds ratio (OR) (95%CI) of steatosis per higher interquartile range (IQR) of log-transformed total urinary As levels (ΣAs, μg/L), and per 5% higher in log-transformed As species (iAs%, MMA%, DMA%).</p><p><strong>Results: </strong>The adjusted ORs (95%CI) for L/S < 1.0 were 1.09 (0.91, 1.30) per higher IQR of ΣAs, and 0.80 (0.68, 0.95), 0.69 (0.61, 0.77), and 1.24 (1.15, 1.34) per 5% higher iAs%, MMA%, and DMA%, respectively. The corresponding ORs (95% CI) for HU < 40 were 0.99 (0.75, 1.30) per higher IQR of increase ΣAs, and 0.70 (0.50, 0.91), 0.65 (0.55, 0.78), and 1.31 (1.16, 1.48) per 5% higher iAs%, MMA%, and DMA%, respectively. The associations were consistent by self-reported race/ethnicity and sex.</p><p><strong>Conclusions: </strong>Arsenic methylation capacity, but not exposure, was associated with the prevalence of hepatic steatosis. Studies are needed to examine the longitudinal association between the progression of hepatic steatosis with As metabolism biomarkers and As-related disease. https://doi.org/10.1289/EHP16728.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Association of Arsenic Exposure and Metabolism Biomarkers with Subclinical Measures of Liver Disease: a cross-sectional investigation in the Multi-Ethnic Study of Atherosclerosis.\",\"authors\":\"Hui-Chen Wu, Ronald A Glabonjat, Kathrin Schilling, William A Anderson, Siyue Gao, Arce Domingo Relloso, Nancy LoIacono, Monique Slowly, Anne E Nigra, Tiffany Sanchez, Marisa H Sobel, Marta Galvez-Fernandez, Matthew J Budoff, Mary V Gamble, Ana Navas-Acien, Mariana Lazo\",\"doi\":\"10.1289/EHP16728\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Long-term exposure to arsenic (As) can cause many health effects and As metabolism is key in the detoxification and elimination of As. We hypothesize that hepatic steatosis might affect As metabolism efficiency. We evaluated the association of As exposure and As metabolism biomarkers with hepatic steatosis.</p><p><strong>Methods: </strong>In this cross-sectional analysis, we analyzed data from 3,577 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), an ethnically diverse US adult population, with urinary metals and liver CT scan data available. We measured total As and As species in urine, and summarized As methylation biomarkers as inorganic (iAs%), monomethylarsonic acid (MMA%), and dimethylarsinic acid (DMA%). The ratio of liver-to-spleen (L/S) Hounsfield units (HU) < 1.0 and liver attenuation < 40 HU were used to assess the presence and severity of liver fat content. We used logistic regression to estimate the odds ratio (OR) (95%CI) of steatosis per higher interquartile range (IQR) of log-transformed total urinary As levels (ΣAs, μg/L), and per 5% higher in log-transformed As species (iAs%, MMA%, DMA%).</p><p><strong>Results: </strong>The adjusted ORs (95%CI) for L/S < 1.0 were 1.09 (0.91, 1.30) per higher IQR of ΣAs, and 0.80 (0.68, 0.95), 0.69 (0.61, 0.77), and 1.24 (1.15, 1.34) per 5% higher iAs%, MMA%, and DMA%, respectively. The corresponding ORs (95% CI) for HU < 40 were 0.99 (0.75, 1.30) per higher IQR of increase ΣAs, and 0.70 (0.50, 0.91), 0.65 (0.55, 0.78), and 1.31 (1.16, 1.48) per 5% higher iAs%, MMA%, and DMA%, respectively. The associations were consistent by self-reported race/ethnicity and sex.</p><p><strong>Conclusions: </strong>Arsenic methylation capacity, but not exposure, was associated with the prevalence of hepatic steatosis. Studies are needed to examine the longitudinal association between the progression of hepatic steatosis with As metabolism biomarkers and As-related disease. https://doi.org/10.1289/EHP16728.</p>\",\"PeriodicalId\":11862,\"journal\":{\"name\":\"Environmental Health Perspectives\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":10.1000,\"publicationDate\":\"2025-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Health Perspectives\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1289/EHP16728\",\"RegionNum\":1,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Health Perspectives","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1289/EHP16728","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
The Association of Arsenic Exposure and Metabolism Biomarkers with Subclinical Measures of Liver Disease: a cross-sectional investigation in the Multi-Ethnic Study of Atherosclerosis.
Background: Long-term exposure to arsenic (As) can cause many health effects and As metabolism is key in the detoxification and elimination of As. We hypothesize that hepatic steatosis might affect As metabolism efficiency. We evaluated the association of As exposure and As metabolism biomarkers with hepatic steatosis.
Methods: In this cross-sectional analysis, we analyzed data from 3,577 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), an ethnically diverse US adult population, with urinary metals and liver CT scan data available. We measured total As and As species in urine, and summarized As methylation biomarkers as inorganic (iAs%), monomethylarsonic acid (MMA%), and dimethylarsinic acid (DMA%). The ratio of liver-to-spleen (L/S) Hounsfield units (HU) < 1.0 and liver attenuation < 40 HU were used to assess the presence and severity of liver fat content. We used logistic regression to estimate the odds ratio (OR) (95%CI) of steatosis per higher interquartile range (IQR) of log-transformed total urinary As levels (ΣAs, μg/L), and per 5% higher in log-transformed As species (iAs%, MMA%, DMA%).
Results: The adjusted ORs (95%CI) for L/S < 1.0 were 1.09 (0.91, 1.30) per higher IQR of ΣAs, and 0.80 (0.68, 0.95), 0.69 (0.61, 0.77), and 1.24 (1.15, 1.34) per 5% higher iAs%, MMA%, and DMA%, respectively. The corresponding ORs (95% CI) for HU < 40 were 0.99 (0.75, 1.30) per higher IQR of increase ΣAs, and 0.70 (0.50, 0.91), 0.65 (0.55, 0.78), and 1.31 (1.16, 1.48) per 5% higher iAs%, MMA%, and DMA%, respectively. The associations were consistent by self-reported race/ethnicity and sex.
Conclusions: Arsenic methylation capacity, but not exposure, was associated with the prevalence of hepatic steatosis. Studies are needed to examine the longitudinal association between the progression of hepatic steatosis with As metabolism biomarkers and As-related disease. https://doi.org/10.1289/EHP16728.
期刊介绍：
Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.
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