Pre-disease biomarkers of persistent organic pollutants (POPs) and amyotrophic lateral sclerosis (ALS) risk in Finland.

IF 10.1 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ian W Tang, Paul Knekt, Panu Rantakokko, Markku Heliövaara, Harri Rissanen, Päivi Ruokojärvi, Rajarshi Mukherjee, Marc G Weisskopf
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引用次数: 0

Abstract

Background: Persistent organic pollutants (POPs) are toxic chemicals that bioaccumulate and were used in pesticides and industrial products/processes. POP-exposed occupations and environmental exposure to POPs have been associated with amyotrophic lateral sclerosis (ALS), but no study has evaluated the association with ALS when measuring POPs in samples collected before ALS onset.

Objectives: This study examined the relationship between pre-disease POP exposure and ALS risk.

Methods: We conducted a nested case-control study pooling three Finnish cohorts (n=56,862). During a median follow-up of 27 years, 97 incident ALS cases were identified (mean age at ALS=68). Within each cohort, two controls per case were selected by individual matching for age, sex, municipality, and serum freeze-thaw cycles. Thirteen polychlorinated biphenyls (PCB) and nine organochlorine pesticides (OCP) were determined in serum samples collected at baseline and stored at -20C. We considered these POPs both in groups (similar congener, isomer, metabolite groups) and separately. Odds ratios and 95% confidence intervals were estimated using a conditional logistic model in a two-stage approach, further adjusting for smoking, occupation, marital status, BMI, and serum cholesterol level in primary models.

Results: In the main model hexachlorobenzene (HCB) showed a positive association with ALS occurrence. In contrast, Σnon-dioxin-like (NDL) PCB and ΣDDT were significantly inversely associated with ALS incidence. Most other POP groups were non-significantly inversely associated with ALS risk. In co-pollutant models, the only notable changes were that Σdioxin-like PCB and ΣHCH showed large non-significant, elevated, ORs, suggesting some negative co-pollutant confounding. There were some suggestions of stronger findings when limiting to some subgroups.

Discussion: We found little evidence that POPs were associated with ALS, but we identified a suggestive positive association with HCB and HCH. ΣNDL PCB and ΣDDT were inversely associated with ALS. This could suggest protective mechanisms or uncontrolled confounding by neuroprotective factors (e.g. fish oils). https://doi.org/10.1289/EHP16539.

芬兰持久性有机污染物(POPs)和肌萎缩侧索硬化症(ALS)风险的病前生物标志物
背景:持久性有机污染物(POPs)是生物积累的有毒化学物质,用于农药和工业产品/工艺。暴露于持久性有机污染物的职业和环境暴露与肌萎缩性侧索硬化症(ALS)有关,但在测量ALS发病前收集的样本中的持久性有机污染物时,没有研究评估其与ALS的关系。目的:本研究探讨疾病前POP暴露与ALS风险之间的关系。方法:我们进行了一项巢式病例对照研究,纳入了三个芬兰队列(n=56,862)。在中位27年的随访期间,发现了97例ALS病例(ALS时平均年龄为68岁)。在每个队列中,通过年龄、性别、城市和血清冻融周期的个体匹配,每个病例选择两个对照。在-20℃保存的血清样品中检测了13种多氯联苯(PCB)和9种有机氯农药(OCP)。我们将这些持久性有机污染物分为两组(相似的同系物、异构体、代谢物组)和单独考虑。比值比和95%置信区间采用两阶段方法的条件logistic模型进行估计,并在初级模型中进一步调整吸烟、职业、婚姻状况、BMI和血清胆固醇水平。结果:在主要模型中,六氯苯(HCB)与ALS的发生呈正相关。相反,Σnon-dioxin-like (NDL) PCB和ΣDDT与ALS发病率呈显著负相关。大多数其他POP组与ALS风险无显著负相关。在共污染物模型中,唯一显著的变化是Σdioxin-like PCB和ΣHCH显示出较大的、不显著的、升高的or,这表明存在一些负的共污染物混淆。当限制在某些亚组时,有一些更强的发现的建议。讨论:我们几乎没有发现持久性有机污染物与ALS相关的证据,但我们确定了与六氯环己烷和六氯环己烷的暗示性正相关。ΣNDL PCB和ΣDDT与ALS呈负相关。这可能表明保护机制或不受控制的神经保护因素(如鱼油)混淆。https://doi.org/10.1289/EHP16539。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Environmental Health Perspectives
Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
14.40
自引率
2.90%
发文量
388
审稿时长
6 months
期刊介绍: Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.
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