特定来源的空气污染与慢性阻塞性肺疾病的风险:一项汇总队列研究

IF 9.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Manuella Lech Cantuaria, Aslak Harbo Poulsen, Ole Raaschou-Nielsen, Étienne Audureau, Ralph Epaud, Sophie Lanone, Jørgen Brandt, Lisa Marie Frohn, Matthias Ketzel, Anja Olsen, Lau Caspar Thygesen, Mette Sørensen
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引用次数: 0

摘要

背景:长期暴露于空气污染与慢性阻塞性肺疾病(COPD)发展之间的证据仍然存在争议。此外,大多数研究都研究了颗粒物(PM)和二氧化氮(NO2)的相关性,而忽略了它们的排放源和其他相关的空气污染物,如超细颗粒(UFP)和单质碳(EC)。目的:本研究旨在评估长期居住暴露于PM2.5、NO2、UFP和EC与COPD风险之间的关系,区分来自当地交通和其他来源的空气污染的影响。方法:我们汇集了两个大型丹麦队列的数据——饮食、癌症和健康队列和丹麦国家健康调查。对于所有参与者(N = 159,769),我们根据完整的地址历史估算了长期空气污染暴露对总、当地交通和其他贡献的影响。我们使用Cox比例风险模型来估计10年时间加权平均空气污染与COPD事件之间的关联,并对人口统计学、社会经济和生活方式因素(包括吸烟)进行了调整。我们评估了性别、吸烟状况和既往哮喘诊断可能改变这些关联的可能性。结果:长期暴露于PM2.5、NO2、UFP和EC与COPD的高风险相关。经完全校正后,PM2.5在总贡献四分位数范围内的风险比(HR)最高(HR: 1.11[95%置信区间:1.05,1.17]),其次是NO2(1.08[1.04, 1.13])、UFP(1.05[0.99, 1.11])和EC(1.02[1.00, 1.05])。与本地交通PM2.5相比,其他来源的PM2.5与慢性阻塞性肺病的相关性更强,而对于UFP和EC,本地交通的贡献似乎是最有害的。效应修正分析显示,在女性、从不吸烟者和哮喘患者之间存在更强的相关性。讨论:我们的研究结果表明,来自当地交通和其他来源的空气污染会导致COPD风险,其差异取决于污染物类型。需要进一步的研究在不同的人群和地理环境中验证这些发现。https://doi.org/10.1289/EHP16554。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Source-specific air pollution and risk of chronic obstructive pulmonary disease: A pooled cohort study.

Background: The evidence linking long-term exposure to air pollution and development of chronic obstructive pulmonary disease (COPD) is still controversial. Furthermore, most studies have investigated associations with particulate matter (PM) and nitrogen dioxide (NO2), disregarding their emission source and other relevant air pollutants, such as ultrafine particles (UFP) and elemental carbon (EC).

Objectives: This study aimed to assess associations between long-term residential exposure to PM2.5, NO2, UFP, and EC and risk of COPD, distinguishing the effects of air pollution from local traffic and other sources.

Methods: We pooled data from two large Danish cohorts - the Diet, Cancer, and Health cohort and the Danish National Health Survey. For all participants (N = 159,769), we estimated long-term air pollution exposure to total, local traffic, and other contributions, based on complete address histories. We used Cox proportional hazards models to estimate associations between 10-year time-weighted averaged air pollution and incident COPD, adjusting for demographic, socioeconomic, and lifestyle factors, including smoking.We evaluated possible modification of these associations by sex, smoking status, and previous asthma diagnosis.

Results: Long-term exposures to PM2.5, NO2, UFP, and EC were associated with higher risk of COPD. The highest hazard ratio (HR) per interquartile range of total contributions was observed for PM2.5 (HR: 1.11 [95% confidence interval: 1.05, 1.17]), followed by NO2 (1.08 [1.04, 1.13]), UFP (1.05 [0.99, 1.11]), and EC (1.02 [1.00, 1.05]), after full adjustment. PM2.5 from other sources than local traffic was more strongly associated with COPD than PM2.5 from local traffic, while for UFP and EC, the contributions from local traffic seemed most harmful. Effect modification analyses showed stronger associations among women, never smokers, and those with an asthma diagnosis.

Discussion: Our findings suggest that air pollution from local traffic and other sources contribute to COPD risk, with variations depending on the pollutant type. Further research is needed to validate these findings across different populations and geographical settings. https://doi.org/10.1289/EHP16554.

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来源期刊
Environmental Health Perspectives
Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
14.40
自引率
2.90%
发文量
388
审稿时长
6 months
期刊介绍: Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.
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