Epilepsy & Behavior最新文献

{"title":"Influence of mindfulness meditation on intracranial EEG parameters in epileptic and non-epileptic brain areas","authors":"Daniel D. Cummins ,&nbsp;Zac Schulman ,&nbsp;Christina Maher ,&nbsp;Lea Tortolero ,&nbsp;Adam Saad ,&nbsp;Lizabeth Nunez Martinez ,&nbsp;Richard J. Davidson ,&nbsp;Lara V. Marcuse ,&nbsp;Ignacio Saez ,&nbsp;Fedor Panov","doi":"10.1016/j.yebeh.2024.110150","DOIUrl":"10.1016/j.yebeh.2024.110150","url":null,"abstract":"<div><h3>Objective</h3><div>Mind-wandering is a pervasive human brain state and, when in excess, may promote negative affect and neuropsychiatric conditions. Mindfulness meditation may promote alternate brain states, improving affect and reducing stress. An understanding of the neural basis between these brain states could thus advance treatment of neuropsychiatric conditions, including those associated with epilepsy.</div></div><div><h3>Methods</h3><div>To explore the neural basis of mindfulness meditation versus mind-wandering, we enrolled eight patients in a trial of structured mindfulness meditation and open mind-wandering who underwent stereo electroencephalography (sEEG) within the mesial temporal lobe for seizure localization. Electrophysiology was compared between mind-wandering and mindfulness separately for epileptic and non-epileptic MTL. Using fitting-one-over-f modeling, periodic components of electrophysiology were compared in canonical frequency bands of theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz), and gamma (30–55 Hz). Aperiodic components of the power spectra were assessed by the model offset, knee, and exponent.</div></div><div><h3>Results</h3><div>We found a significant reduction in gamma power (30–55 Hz) within the mesial temporal lobe (MTL) during mindfulness meditation compared with mind-wandering in non-epileptic (p = 1.20E-4) but not in epileptic MTL (p = 0.352).There was also a significant difference between epileptic versus non-epileptic MTL in gamma power between conditions (p = 0.011). There were no significant changes in power across any frequency band within epileptic mesial temporal MTL between brain states. Conversely, there were significant differences between mind-wandering and mindfulness within epileptic MTL in aperiodic components (offset, knee, and exponent, all p &lt; 0.05), while no differences in aperiodic components were seen in non-epileptic MTL (all p &gt; 0.70).</div></div><div><h3>Significance</h3><div>Intracranial electrophysiologic modulations between brain state (mind-wandering versus mindfulness) may differ between epileptic and non-epileptic MTL. Modulations in gamma activity in non-epileptic MTL may represent functional changes in brain state, while aperiodic changes in epileptic MTL may modulate propensity for seizures.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110150"},"PeriodicalIF":2.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vagal nerve stimulation on patients with bilateral temporal lobe epilepsy","authors":"Ashwaq Alshahrani ,&nbsp;Jorge G. Burneo ,&nbsp;David A. Steven ,&nbsp;Michelle-Lee Jones ,&nbsp;Keith W. MacDougall ,&nbsp;Jonathan C. Lau ,&nbsp;Derek B. Debicki ,&nbsp;Tenielle Gofton ,&nbsp;David C. Diosy ,&nbsp;Richard S. McLachlan ,&nbsp;Ana Suller Marti","doi":"10.1016/j.yebeh.2024.110138","DOIUrl":"10.1016/j.yebeh.2024.110138","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of vagus nerve stimulation (VNS) on the seizure frequency in patients with drug-resistant epilepsy (DRE) and bilateral temporal lobe epilepsy (bi-TLE). Additionally, we aimed to determine the safety of VNS and its side effects.</div></div><div><h3>Methods</h3><div>Our retrospective study included 17 patients with bi-TLE who underwent VNS-device implantation at our center from 1997 to 2019. The main outcome was a reduction in seizure frequency. Bitemporal cases were confirmed using scalp electroencephalography (EEG) or invasive electroencephalography (iEEG).</div></div><div><h3>Results</h3><div>The median age at seizure onset was 18 years. Bi-TLE was confirmed by scalp EEG in 47 % and by iEEG in 53 % of the patients. The median follow-up period was 36 months. The median seizure frequency per month before and after VNS was 9.5 (IQR = 4.3–35.3) and 2 (IQR = 0.8–4.2), respectively. Compared to baseline, 70.5 % of the patients achieved ≥ 50 % reduction in seizure frequency, whereas 35.3 % experienced either no or minimal reduction in seizure frequency. The response rate (&gt;50 % reduction in seizure frequency) was 87.5 % in patients who underwent scalp EEG and 55.5 % in those who underwent iEEG. For VNS treatment, the median follow-up was at 36 months (IQR = 17–46.5). Adverse effects were observed in 59 % of the patients, including cough and hoarseness.</div></div><div><h3>Discussion</h3><div>Therapeutic choices are limited in cases of drug-resistant bi-TLE. Our study on VNS-device implantation in bi-TLE suggests a positive outcome.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110138"},"PeriodicalIF":2.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the Epilepsy Perceived Stress Inventory for Adults (EPSI-A): A pilot study","authors":"Judit Catalán-Aguilar ,&nbsp;Irene Cano-López ,&nbsp;Paula Tormos-Pons ,&nbsp;Alejandro Lozano-García ,&nbsp;Kevin G. Hampel ,&nbsp;Vanesa Hidalgo ,&nbsp;Alicia Salvador ,&nbsp;Vicente Villanueva ,&nbsp;Esperanza González-Bono","doi":"10.1016/j.yebeh.2024.110142","DOIUrl":"10.1016/j.yebeh.2024.110142","url":null,"abstract":"<div><h3>Introduction</h3><div>Stress is one of the most common trigger factors for epileptic seizures and is strongly related to clinical and emotional variables. Despite its influence in the course of the disease, there is an absence of instruments for measuring perceived stress in people with drug-resistant epilepsy. Therefore, this study develops and validates the Epilepsy Perceived Stress Inventory for Adults (EPSI-A), a self-report inventory in Spanish designed to quantify perceived chronic stress in this population.</div></div><div><h3>Method</h3><div>The sample consisted of 236 patients with drug-resistant epilepsy who underwent a neuropsychological assessment in which anxiety, depression, and quality of life were explored. In addition, from 125 patients in the sample, 9 measures of salivary cortisol were collected during the evaluation.</div></div><div><h3>Results</h3><div>The EPSI-A consisted of 15 items, with higher scores indicating higher perceived stress. The exploratory factor analysis showed a four-factor solution: <em>epilepsy concerns</em> (5 items); <em>impact on daily performance</em> (4 items); <em>social consequences</em> (3 items); and <em>epilepsy severity</em> (3 items). These factors explained 63.3 % of the total variance. Internal consistency reliability measured with McDonald’s omega and Cronbach’s alpha coefficients was satisfactory, with values ≥ 0.78 (except for epilepsy severity with values of 0.59 and 0.58, respectively). Construct validity was demonstrated by its correlation with several psychological scales and clinical variables.</div></div><div><h3>Conclusions</h3><div>The results showed that the EPSI-A is a reliable and valid tool for assessing perceived chronic stress in people with epilepsy. Its conciseness, rapid administration time, and specificity make it an appropriate instrument for this population.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110142"},"PeriodicalIF":2.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality psychopathology in temporal lobe epilepsy: An Arabian study","authors":"Maria Joy Khachan ,&nbsp;Joakima Khachan ,&nbsp;Nicole Tannous ,&nbsp;Jad El Ahdab ,&nbsp;Georges Raad ,&nbsp;Kamal Kallab","doi":"10.1016/j.yebeh.2024.110122","DOIUrl":"10.1016/j.yebeh.2024.110122","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous research has linked epilepsy of the temporal lobe (TLE) with comorbidities of psychiatric nature, yet few studies have investigated personality psychopathology in patients with TLE. This is the first study on the topic in the Arab world and the first study using the Personality Inventory for DSM-5-Brief From (PID-5-BF). Thus, this study, which is cross-sectional by nature, aims to explore the potential relationship between TLE and personality psychopathology.</div></div><div><h3>Methods</h3><div>Utilizing the validated Arabic version of the Personality Inventory for DSM-5 − Brief Form (PID-5-BF), this study compared average total scores and domain scores among 24 TLE patients and 48 controls from the general population, using the Independent Samples <em>t</em>-test. Binary logistic regression used to assess the impact of gender and age on personality psychopathology in both the TLE and control group.</div></div><div><h3>Results</h3><div>Following adjustment for age and gender, notable disparities emerged in average total scores (p &lt; 0.001), as well as negative affect (p &lt; 0.0001), disinhibition (p &lt; 0.04), and psychoticism scores (p &lt; 0.01), with TLE patients exhibiting higher scores across these domains with a score of 1.28, 2.00, 1.08 and 1.25 respectively compared to controls with a score of 0.85, 1.08, 0.69 and 0.69 respectively. Nevertheless, analyses investigating age and gender as predictors for personality psychopathology yielded non-significant results in both groups.</div></div><div><h3>Discussion</h3><div>The study hints at a possible positive link between TLE and personality psychopathology, possibly attributable to limbic system involvement. This is the first study of its kind in the Arab world, highlighting a neglected topic in the region. While these results hold clinical implications, further research is warranted to validate these relationships.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110122"},"PeriodicalIF":2.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapeutic strategies for drug-resistant epilepsy in children","authors":"Stéphane Auvin ,&nbsp;Nicola Specchio","doi":"10.1016/j.yebeh.2024.110139","DOIUrl":"10.1016/j.yebeh.2024.110139","url":null,"abstract":"<div><div>Drug resistance is defined as the failure of adequate trials of two tolerated and appropriately chosen antiseizure medications to achieve sustained seizure freedom. In case of uncontrolled seizures, pseudo-drug-resistance (poor compliance, a worsening effect of an antiseizure medication, a diagnosis of psychogenic non-epileptic seizure) should be first ruled out in case of pediatric epilepsies. This paper discusses the process of choosing antiseizure medication and the concepts of rationale polytherapy and precision medicine. In drug-resistant epilepsy, when curative surgery is not feasible, the aim of the treatment is focused on the improvement of quality of life rather than on seizure count. In recent years, despite an increase in available antiseizure medications, the incidence of drug-resistant epilepsy has not changed. Precision medicine may offer in rare epilepsies a mechanism-driven treatment, but it is still unclear if this will end up in an improvement of efficacy in drug-resistant epilepsies. Gene therapy with antisense oligonucleotides or Adeno-associated Virus (AAV) is transitioning from the experimental side to the first human trial. It may modify the natural history of selected epileptic syndromes.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110139"},"PeriodicalIF":2.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of ADHD in children with childhood absence epilepsy versus controls: A population-based study","authors":"Saskia L. Vanderwiel ,&nbsp;Brandon Jones ,&nbsp;Katherine C. Nickels ,&nbsp;Lily C. Wong-Kisiel ,&nbsp;Anthony Fine ,&nbsp;Jay Mandrekar ,&nbsp;Elaine C. Wirrell","doi":"10.1016/j.yebeh.2024.110143","DOIUrl":"10.1016/j.yebeh.2024.110143","url":null,"abstract":"<div><h3>Introduction</h3><div>Children with childhood absence epilepsy (CAE) are deemed to be at higher risk of attention deficit hyperactivity disorder (ADHD), however the magnitude of that risk has not been assessed in a population-based study.</div></div><div><h3>Methods</h3><div>The Rochester Epidemiology Project database was used to identify children with a new diagnosis of CAE while resident in Olmsted County, MN between 1980–2018. For each case, four age- and sex-matched controls without epilepsy were identified. Records of cases and controls screening positive for ADHD were reviewed to confirm this diagnosis. Those with comorbid ADHD and CAE were further assessed to determine if the ADHD diagnosis preceded or followed the epilepsy diagnosis, as well as the impact of ADHD treatment on possible seizure exacerbation and long-term epilepsy course.</div></div><div><h3>Results</h3><div>Forty-one cases of CAE were identified and matched to 164 controls. ADHD was diagnosed in 17 children (41.5 %) with CAE and 12 controls (7.3 %) (p &lt; 0.001). Compared to those without epilepsy, the diagnosis of ADHD in CAE was more likely to be made by a mental health professional than a primary care provider (p = 0.047). ADHD in CAE typically followed the diagnosis of CAE and in 7/17 cases, was diagnosed after remission of epilepsy and discontinuation of antiseizure medication. There was no difference in the proportion of cases or controls treated with ADHD medication (16/17 cases and 12/12 controls). Both groups had high likelihood of favorable response to ADHD medication and no child with CAE experienced seizure exacerbation with ADHD treatment.</div></div><div><h3>Conclusions</h3><div>ADHD was 5.7-fold more common in CAE then in children without epilepsy in our population-based study. Treatment with stimulants is highly effective and not associated with worsening of seizures. Primary care providers must be vigilant to carefully screen this population for ADHD.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110143"},"PeriodicalIF":2.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misinformation on first aid for seizures communicated through the fastest growing social media platform: A cross-sectional study of TikTok content","authors":"Alexei A. Birkun","doi":"10.1016/j.yebeh.2024.110116","DOIUrl":"10.1016/j.yebeh.2024.110116","url":null,"abstract":"<div><h3>Introduction</h3><div>Social media platforms have significant potential to enhance public knowledge on how to respond to generalised seizures. Among the platforms, TikTok emerges as a standout performer, demonstrating exceptional user engagement.</div></div><div><h3>Study objective</h3><div>This study aimed to assess the quality of content on first aid for seizures posted on TikTok.</div></div><div><h3>Methods</h3><div>TikTok videos providing instructions on first aid for generalised seizures and having at least 100,000 views were analysed for completeness and correctness of the advice using a 21-item checklist. Any misleading recommendations suggesting inappropriate actions were collected from the videos and users’ comments on the videos.</div></div><div><h3>Results</h3><div>Nineteen eligible videos had a total of 19,502,200 views. The videos frequently omitted key guidelines-concordant instructions on first aid for seizures, in particular, to lay the person down to prevent falling (missed in 84.2% of the videos), avoid moving the person unless they are in danger (89.5%), check the person’s breathing once the seizure has ended (89.5%) and commence cardiopulmonary resuscitation if the person remains unresponsive and not breathing normally (94.7%). Nine videos (47.4%) contained misleading instructions, most commonly to put the person on their side or otherwise move them during the seizure. Multiple comments to the videos advocated futile and dangerous actions, for instance, putting objects into the person’s mouth, restraining, or hitting the person.</div></div><div><h3>Conclusion</h3><div>TikTok videos convey information on first aid for seizures to multi-million audiences concurrently propagating incomplete, inaccurate and potentially harmful non-evidence-based advice. Urgent research and regulatory efforts are needed to develop effective strategies to combat the misinformation spread.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110116"},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions in the experience of transition from pediatric to adult care of patients with childhood-onset epilepsy in Japan","authors":"Takumi Sasaki ,&nbsp;Wataru Irie ,&nbsp;Akiko Sugahara ,&nbsp;Kazutaka Jin ,&nbsp;Nobukazu Nakasato ,&nbsp;Hitoshi Shiwaku","doi":"10.1016/j.yebeh.2024.110119","DOIUrl":"10.1016/j.yebeh.2024.110119","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to clarify perceptions of the transition from pediatric to adult care for patients with childhood-onset epilepsy in Japan.</div></div><div><h3>Methods</h3><div>A qualitative descriptive study design was used. Semi-structured interviews were conducted with patients with childhood-onset epilepsy who had transitioned to adult care attending a tertiary hospital’s adult outpatient care unit specializing in treating epilepsy. Data were analyzed using content analysis to extract perceptions regarding the transition from pediatric to adult care.</div></div><div><h3>Result</h3><div>Six male and seven female patients between the ages of 18 and 49 years participated in the study. Seventeen perception categories regarding the experience of transitioning from pediatric to adult care were identified: {I followed a specific transfer process}, {I want to transition to adult care}, {I want to remain in pediatrics},{I have noticed something after transitioning to adult care}, {I recall trust in pediatricians}, {increased motivation for self-management}, and {I want detailed explanations about illness}.</div></div><div><h3>Conclusions</h3><div>The patients wanted to transition to adult medicine, but were passive, waiting for their physicians to suggest the transition. Furthermore, their perceptions of their own self-care varied. Pediatric healthcare providers should discuss and support the decision to transition from pediatric to adult care and provide information to help patients with childhood-onset epilepsy accept their future and understand their self-management requirements. These patients may become independent through the transition to adult care, and collaboration between pediatric and adult medicine is important to pass the responsibility of self-support to medical providers in adult care.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110119"},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of psychological and neurocognitive processes accompanying functional seizures","authors":"Lana Higson ,&nbsp;Terence J O’Brien ,&nbsp;Zhibin Chen ,&nbsp;Genevieve Rayner ,&nbsp;Rubina Alpitsis ,&nbsp;Toby Winton-Brown","doi":"10.1016/j.yebeh.2024.110117","DOIUrl":"10.1016/j.yebeh.2024.110117","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the relationship between clinical, psychological, and cognitive characteristics of adults with functional seizures. <strong>Methods:</strong> This study describes baseline characteristics of one-hundred and seven participants with a documented diagnosis of functional seizures recruited to the Re-PROGRAM randomised controlled trial. Participants completed a semi-structured interview, neuropsychological assessment, and questionnaire measures via Telehealth. <strong>Results:</strong> Participants reported low levels of trust in body sensations, high levels of negative ruminative thinking, dissociation, somatisation, anxiety, depression, severe levels of functional impairment, and poor quality of life. At a group level, they had normal neurocognitive function, including mental control, processing speed, attention, and executive function. Anxiety (73%), depression (68%), post-traumatic stress disorder (49%), migraine (63%) and chronic pain (52%) were common comorbidities. Forty-three percent reported a family history of dementia. Somatic symptoms were associated with depression, anxiety, dissociation, ruminative negative thinking, and lower scores on the ’Not-distracting’ interoception scale. Poorer psychosocial functioning was associated with depression and dissociation. Reduced mental quality of life was associated with higher levels of depression, anxiety, dissociation, ruminative negative thinking, and lower scores on the ‘Trusting’ interoception scale. There were no associations between the clinical or psychological variables and seizure frequency or seizure classification. Neither cognitive impairment nor failure on effort testing were associated with the clinical or psychological factors, quality of life or psychosocial functioning. <strong>Significance:</strong> This study highlights the burden of psychiatric and physical comorbidity; and the relationship between psychological factors and functional impairment in a large cohort of patients with functional seizures despite normal cognitive function.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110117"},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated acoustic stimulation (audiogenic kindling) induces estrous arrest in the Wistar audiogenic Rat (WAR) strain. A model of pseudopregnancy?","authors":"Matheus Credendio Eiras ,&nbsp;Carolina Gennari Verruma ,&nbsp;Artur Fernandes ,&nbsp;Ester Silveira Ramos ,&nbsp;Cristiana Libardi Miranda Furtado ,&nbsp;Norberto Garcia-Cairasco ,&nbsp;Rosana Maria dos Reis","doi":"10.1016/j.yebeh.2024.110125","DOIUrl":"10.1016/j.yebeh.2024.110125","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy is a chronic disorder characterized by a predisposition to epileptic seizures, affecting more than 50 million people worldwide.</div></div><div><h3>Methods</h3><div>Wistar and Wistar Audiogenic Rats (WAR) females were evaluated regarding estrous cycle and seizures episodes during repeated (kindling) acoustic stimulation at different stages of the estrous cycle.</div></div><div><h3>Results</h3><div>Acoustic stimulation did not affect the estrous cycle of most Wistar females in either control (91.6 %) or kindled (70.0 %) groups. They also had no seizures episodes. In WAR females, most of the control group (91.6 %) showed regular cycles during acoustic stimulation. In the kindling group, all females showed irregular cycles during acoustic stimulation with diestrus arrest for several days (11.8 ± 1.46 days) and 12 of them (92.3 %) showed, at least, four mesencephalic seizure behaviors during the acoustic stimulation (1 ≤ cSI ≤ 8). In this group, 7 females (53.84 %) also showed limbic seizures (2 ≤ LI ≤ 4). When WAR females were stratified by estrous cycle stage, the group that started the acoustic stimulation during estrus had five females (45.4 %) with diestrus arrest for several days (11.4 ± 0.89 days) and, eight females (72.7 %) exhibited, at least, two seizure behaviors (1 &lt; cSI &lt; 8). When acoustic stimulation was started in the metestrus stage, six females (54.5 %) exhibited diestrus arrest for several days (10.5 ± 3.27 days). In the metestrus group, ten females (90.9 %) presented five or six seizure episodes (1 &lt; cSI &lt; 8).</div></div><div><h3>Conclusion</h3><div>Our results showed that chronic audiogenic seizures (audiogenic kindling) affect the estrous cycle of WAR females, resulting in a consistent diestrus arrest for 10–12 days, which is consistent with the phenomenon of pseudopregnancy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"161 ","pages":"Article 110125"},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}