Epilepsy & Behavior最新文献

{"title":"Identification of neuro-inflammatory biomarkers through non-invasive advanced neuroimaging techniques in pharmaco-resistant epilepsy: A systematic review","authors":"Dayana Haidar Shoukair ,&nbsp;Rania El Majzoub ,&nbsp;Mariam Kassem ,&nbsp;Ali Ismail ,&nbsp;Ghida Safadieh ,&nbsp;Jana Kotaich ,&nbsp;Elissa El Toum ,&nbsp;Mohammad Fayyad-Kazan ,&nbsp;Bahia Chahine","doi":"10.1016/j.yebeh.2025.110641","DOIUrl":"10.1016/j.yebeh.2025.110641","url":null,"abstract":"<div><h3>Objectives</h3><div>The primary aim is to conduct a comprehensive review focusing on the identification of neuro-inflammatory biomarkers using advanced non-invasive neuroimaging tools in pharmaco-resistant epilepsy.</div></div><div><h3>Methods</h3><div>A systematic search was conducted through four different databases, namely PubMed, Embase, Web of Science, and Google Scholar. Title and abstract screening, full text assessment, data extraction, and quality evaluation, were performed by two independent reviewers. ARRIVE 2.0 guidelines tool, was used to evaluate the quality of the included studies in this review.</div></div><div><h3>Results</h3><div>A total of 562 records were generated through literature search. Among these, 12 experimental studies met the eligibility criteria, and were included in the qualitative review. These studies identified the following six neuroinflammatory biomarkers in pharmacoresistant epilepsy: TSPO, BBBD, HMGB1, LRP1, P-gp, and MPO. TSPO was the most frequent identified biomarker by six studies out of 12. Within the included studies, eight use positron emission tomography (PET) as their neuroimaging modality of choice, five employ magnetic resonance imaging (MRI), with one specifically employing an MRI T2 sequence, four utilize single photon emission computed tomography (SPECT), and one study uses computed tomography (CT) imaging technique.</div></div><div><h3>Conclusion</h3><div>This review identified six neuroinflammatory biomarkers in drug-resistant epilepsy using noninvasive neuroimaging tools. These biomarkers could be used as diagnostic, predictive, and therapeutic targets. Moreover, they can be used to delineate epileptic foci in the presurgical evaluation of refractory epileptic patients. However, these studies are still in the preclinical phase, requiring further research in this field.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110641"},"PeriodicalIF":2.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden Unexpected Death in Epilepsy (SUDEP) Summit: Recommendations and priorities for clinical action, awareness, public health and epidemiology, and basic science","authors":"Sloka S. Iyengar ,&nbsp;Gardiner Lapham ,&nbsp;Jeffrey R. Buchhalter ,&nbsp;Gordon F. Buchanan ,&nbsp;Elizabeth J. Donner ,&nbsp;Sonya B. Dumanis ,&nbsp;Caitlin L. Grzeskowiak ,&nbsp;Brandy E. Fureman ,&nbsp;Lawrence J. Hirsch ,&nbsp;Alison Kukla ,&nbsp;Owen L. Middleton ,&nbsp;Lori L. Isom ,&nbsp;Daniel Friedman ,&nbsp;Sally Schaeffer ,&nbsp;David S. Auerbach","doi":"10.1016/j.yebeh.2025.110648","DOIUrl":"10.1016/j.yebeh.2025.110648","url":null,"abstract":"<div><h3>Background</h3><div>It remains difficult to predict who will succumb to Sudden Unexpected Death in Epilepsy (SUDEP). As the mechanisms for SUDEP remain unknown, there are not adequate strategies to prevent SUDEP. Thus, some providers are reluctant to discuss SUDEP risk with patients. Public health surveillance and prevention efforts are limited. The SUDEP Summit aimed to identify gaps in the field and prioritize recommendations to advance basic science, clinical care, and public health approaches to mitigate SUDEP.</div></div><div><h3>Methods</h3><div>In 2020, a diverse group of stakeholders formed the four SUDEP Summit workgroups: 1. Clinical Action, 2. Awareness and Behavior Change, 3. Public Health and Epidemiology, and 4. Basic Science.</div></div><div><h3>Results</h3><div>Each workgroup defined priorities for action and necessary resources and partners; outlined challenges and barriers; defined metrics of success; and developed short and long-term goals. Workgroups discussed methods to prioritize SUDEP research and develop educational materials for healthcare professionals to raise awareness about the risks of SUDEP. Since the meeting, progress has been made in alignment with the workgroups’ recommendations. These include studies examining the use of wearables, clinical trials reporting SUDEP rates, tools to improve SUDEP education, policies to improve SUDEP reporting, SUDEP risk calculators, new clinically relevant models, and standardization of data collection.</div></div><div><h3>Significance</h3><div>Advancements in SUDEP awareness, education, epidemiology, and causal mechanisms require interdisciplinary collaborative approaches between funding agencies, advocacy groups, providers, and researchers; and the development of new partnerships. More work remains to achieve the recommendations from the Summit, which highlight the fundamental importance of coordinating efforts to mitigate and end SUDEP.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110648"},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances and health-related quality of life in children with epilepsy: A caregiver survey","authors":"Luc Wiesmüller ,&nbsp;Didare Strauch ,&nbsp;Jan Schönberger ,&nbsp;Victoria San Antonio-Arce ,&nbsp;Thomas Bast ,&nbsp;Susanne Schubert-Bast ,&nbsp;Steffen Syrbe ,&nbsp;Julia Jacobs ,&nbsp;Kerstin Alexandra Klotz","doi":"10.1016/j.yebeh.2025.110613","DOIUrl":"10.1016/j.yebeh.2025.110613","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep disorders are common in patients with epilepsy. In adults, evidence suggests reduced sleep quality and its negative impact on health-related quality of life (HRQoL). However, data on large pediatric cohorts remain limited. This study investigates the relationship between epilepsy and subjective sleep quality as well as its association with HRQoL in a large cohort of children with epilepsy (CWE).</div></div><div><h3>Material and Methods</h3><div>A parental online survey was conducted for CWE up to 15 years. Biographical and medical information was collected and standardized questionnaires were administered to assess parent reported sleep quality (Children’s Sleep Habit Questionnaire), and HRQoL (KINDL®-questionnaire).</div></div><div><h3>Results</h3><div>A total of 304 CWE (52.3 % male) were surveyed, with a median age of 7 years (range 1–15). Seizure frequency varied from daily (25 %) to less than once per year (24.7 %). Antiseizure medication (ASM) was used in 93.8 %, with 30 % receiving ≥ 3 ASMs. Comorbidities, such as autism or ADHD, were reported in 179 children (58.9 %).</div><div>The mean sleep disturbance score was 54.8 (SD 9.4), with 290 children (95.4 %) scoring above 41, indicating impaired sleep. CWE with both, daytime and nocturnal seizures had worse sleep quality compared to those with daytime seizures only (p = 0.027). The use of sedative medications, like clobazam, was associated with impaired sleep quality (p = 0.025) and shorter sleep duration (p = 0.005).</div></div><div><h3>Conclusion</h3><div>CWE experience poorer sleep quality compared to children without epilepsy, especially when nocturnal seizures are present, regardless of the number of ASMs or presence of comorbidities. In CWE, impaired sleep correlates with lower HRQoL.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110613"},"PeriodicalIF":2.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsuicidal self-injurious behavior in people with epilepsy and non-psychotic mental disorders","authors":"Mikhail Zinchuk ,&nbsp;Georgii Kustov ,&nbsp;Sofya Popova ,&nbsp;Flora Rider ,&nbsp;Alexander Yakovlev ,&nbsp;Alla Guekht","doi":"10.1016/j.yebeh.2025.110634","DOIUrl":"10.1016/j.yebeh.2025.110634","url":null,"abstract":"<div><h3>Purpose</h3><div>Persons with epilepsy (PWE) are at an increased risk for self-injurious behaviors. While suicidal behavior in PWE has been the subject of considerable research, data on nonsuicidal self-injury (NSSI) in PWE remains limited. The aim of this study was to describe the basic characteristics of NSSI in PWE and to identify associated sociodemographic, biographical, psychological, and clinical factors.</div></div><div><h3>Methods</h3><div>A cross-sectional study assessed 209 consecutive adult PWE with non-psychotic mental disorders using the Self-Injurious Thoughts and Behaviors Interview, Beck Depression Inventory, State-Trait Anxiety Inventory, Brief Reasons for Living Inventory, Modified 36-Item Personality Inventory for DSM-5 and ICD-11 Brief Form Plus-Modified, World Health Organization Quality of Life – 100, as well as a case-report form, to collect relevant for the study data.</div></div><div><h3>Results</h3><div>Lifetime NSSI was reported by 27.7% of PWE, with cutting, carving hitting, picking a wound, biting, and skin scraping being the most common methods. NSSI in PWE was associated with significant features in sociodemographic (born after 1980), biographical (school bullying), clinical (higher levels of depression, anxiety, suicidal ideation and suicide attempts), and psychological profiles (deficits in suicide resilience factors, more pronounced traits of negative affectivity, detachment, antagonism, and psychoticism), and a poorer quality of life.</div></div><div><h3>Conclusion</h3><div>This is the first study to report methods and other NSSI-related parameters in PWE. NSSI is associated with numerous negative parameters, some of which are potentially modifiable, and may therefore become a target for therapeutic interventions with potential benefit in terms of reducing suicide risk, which is high in this subpopulation of PWE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110634"},"PeriodicalIF":2.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world efficacy and safety of perampanel versus levetiracetam monotherapy for focal epilepsy: A single-center retrospective study","authors":"Yingfang She ,&nbsp;Yide Li ,&nbsp;Shuda Chen ,&nbsp;Xiaowei Xu ,&nbsp;Liemin Zhou","doi":"10.1016/j.yebeh.2025.110630","DOIUrl":"10.1016/j.yebeh.2025.110630","url":null,"abstract":"","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110630"},"PeriodicalIF":2.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between white matter structural connectivity and epilepsy","authors":"Nan Zhang ,&nbsp;Rui Huang ,&nbsp;Xiaoyu Dong","doi":"10.1016/j.yebeh.2025.110642","DOIUrl":"10.1016/j.yebeh.2025.110642","url":null,"abstract":"<div><div>White matter structural connectivity has recently been linked to epilepsy pathogenesis, yet its causal role remains unclear. This study used Mendelian randomization (MR) to investigate the causal relationship between white matter structural connectivity and epilepsy. GWAS summary statistics for white matter structural connectivity were sourced from the UK Biobank, while epilepsy data were obtained from FinnGen R10 and the International League Against Epilepsy (ILAE). Our MR analysis revealed significant causal links between white matter structural connectivity and epilepsy risk. Increased connectivity between the right hemisphere visual and salience/ventral attention networks (<em>RH Vis to RH Sal/VentAttn WMSC</em>) was associated with higher epilepsy risk in FinnGen_R10_FE_STRICT (OR = 2.25, 95 % CI = 1.43–3.56, p &lt; 0.01, FDR P = 0.019). Conversely, increased connectivity between left and right hemisphere salience/ventral attention networks (<em>LH Sal/VentAttn to RH Sal/VentAttn WMSC</em>) was linked to reduced epilepsy risk in FinnGen_R10_GE_STRICT (OR = 0.17, 95 % CI = 0.07–0.46, p &lt; 0.01, FDR P = 0.033). A total of 15 nominally significant associations were identified across datasets. These findings suggest a causal relationship between white matter structural connectivity and epilepsy, offering insights into disease mechanisms and potential therapeutic targets.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110642"},"PeriodicalIF":2.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a community-based online incentivized survey to describe the healthcare and school-based care of adolescents with functional seizures","authors":"Andrea L. Tanner ,&nbsp;Ukamaka M. Oruche ,&nbsp;Claire Burke Draucker","doi":"10.1016/j.yebeh.2025.110636","DOIUrl":"10.1016/j.yebeh.2025.110636","url":null,"abstract":"<div><h3>Introduction</h3><div>Functional seizures have profound effects on adolescents and their families. These adolescents report negative experiences with healthcare and school-based providers that are likely exacerbated by racial/ethnic and socioeconomic disparities. Research with this population has been conducted mainly in clinic settings. This study aimed to (1) Determine if a racially/ethnically and socioeconomically diverse group of adolescents with functional seizures can be recruited via a community-based online incentivized survey, (2) Describe adolescents’ mental health care utilization and parents’ perceptions of encountering disparities in the adolescents’ healthcare, (3) Describe adolescents’ school-based outcomes, and (4) Describe adolescents’ and their parents’ perspectives on school-based care.</div></div><div><h3>Methods</h3><div>A cross-sectional community-based online incentivized survey with adolescents with functional seizures and their parents.</div></div><div><h3>Results</h3><div>A racially/ethnically and socioeconomically diverse sample of 22 adolescents with functional seizures and their parents completed the survey, although recruitment was challenged by a high rate of fraudulent and careless responders. Most adolescent responders were chronically absent from school, and most were receiving mental health treatment. Half of the parents reported health disparities due to race/ethnicity, cost, or both. Parents and adolescents provided valuable insights regarding their perspectives on school-based care for adolescents with functional seizures.</div></div><div><h3>Conclusion</h3><div>School nurses and other healthcare providers should develop strategies to address chronic absenteeism due to functional seizures, assess health disparities experienced by adolescents and their families, combat lack of understanding of functional seizures, and provide informed and compassionate care for this population. Survey researchers should develop a systematic plan using multiple strategies to combat fraudulent responses in survey research.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110636"},"PeriodicalIF":2.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Hughlings Jackson’s dreamy state: dissociative symptoms in temporal lobe epilepsy","authors":"Fiore D’Aprano ,&nbsp;Alice Matson ,&nbsp;Jessamae Pieters ,&nbsp;Jacquie Eyres ,&nbsp;Toby Winton-Brown ,&nbsp;Terence J. O’Brien ,&nbsp;Graeme Jackson ,&nbsp;Sarah J. Wilson ,&nbsp;Charles B. Malpas ,&nbsp;Genevieve Rayner","doi":"10.1016/j.yebeh.2025.110623","DOIUrl":"10.1016/j.yebeh.2025.110623","url":null,"abstract":"<div><h3>Background</h3><div>Transient, dissociative experiences have been attributed to temporal lobe epilepsy (TLE) since at least the time of John Hughlings Jackson in the 1870s, who described how different dissociative symptoms might have distinct clinical potential. While dissociative symptoms are well-understood as a semiological feature of mesial TLE, they can also occur interictally yet remain poorly understood. We systematically examined the frequency, nature, and clinical correlates of dissociative experiences in TLE in an initial effort to better understand their phenotypic features.</div></div><div><h3>Methods</h3><div>157 adults with TLE and 57 healthy controls participated (<em>N</em> = 214). A data-driven statistical approach determined the underlying factor structure of the Wessex Dissociation Scale in this cohort and delineated phenotypic symptom clusters. We then examined group differences in rates of dissociation symptoms, as well as the influence of epilepsy-related and mood factors.</div></div><div><h3>Results</h3><div>People with TLE reported more frequent dissociative experiences (<em>M</em> = 0.96, SD = 0.61) than controls (<em>M</em> = 0.69, <em>SD</em> = 0.38; <em>p &lt;</em> 0.001). A novel five-factor solution of dissociative symptoms emerged, namely intrusive, affective, memory, somatic, and numbing. Memory blanks and somatic distortions were uniquely elevated in TLE. Memory blanks and numbing dissociative symptoms were associated with increased seizure frequency, epilepsy duration, and number of anti-seizure medications. Higher depression and anxiety symptoms were linked to elevated overall dissociative symptoms and scores on each subfactor (<em>r</em> = 0.26–.64; <em>p</em> &lt; 0.01–&lt;.001).</div></div><div><h3>Conclusions</h3><div>People with TLE experience elevated rates of dissociative symptoms in their daily lives. Rather than a general dissociative phenotype, memory- and sensory-related symptoms predominate. The data-driven five-factor model refines earlier understandings and aligns well with contemporary neurocognitive models of epilepsy as a disorder of large-scale network dysfunction, with psychological and epilepsy-specific mechanisms underpinning dissociative experiences in TLE. While the aetiology of these symptoms is complex and multidetermined, TLE nevertheless remains an insightful model for understanding the neurological basis of dissociation more broadly.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110623"},"PeriodicalIF":2.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized and focal epilepsy and pregnancy, delivery and neonatal outcomes: a retrospective cohort study","authors":"Noah Margolese ,&nbsp;Ahmad Badeghiesh ,&nbsp;Haitham Baghlaf ,&nbsp;Aaron Samuels ,&nbsp;Michael H. Dahan","doi":"10.1016/j.yebeh.2025.110640","DOIUrl":"10.1016/j.yebeh.2025.110640","url":null,"abstract":"<div><div>We previously demonstrated associations between maternal epilepsy and pregnancy outcomes. Now, we seek to determine whether these outcomes differ between generalized and focal epilepsy.</div><div>A retrospective cohort study was completed using the HCUP-NIS database. Pregnancy outcomes were compared across generalized and focal epilepsy types, as determined via ICD-9 codes.</div><div>Of 2,596 pregnancies, 1978 women had focal epilepsy and 618 had generalized epilepsy. Focal epilepsy was associated with increased rates of cesarean sections as compared to generalized epilepsy (aOR = 1.27;95 %CI = 1.02–1.57;p = 0.030). Other pregnancy outcomes did not differ significantly, including pregnancy induced hypertension, gestational hypertension, preeclampsia, eclampsia, preeclampsia and eclampsia superimposed on pre-existing hypertension, gestational diabetes mellitus, placenta previa, preterm premature rupture of membranes, preterm delivery, abruptio placenta, chorioamnionitis, operative vaginal delivery, hysterectomy, postpartum hemorrhage, wound complications, maternal death, transfusion, maternal infection, deep venous thrombosis, pulmonary embolism, venous thromboembolism, disseminated intravascular coagulation, small for gestational age, intrauterine fetal demise and congenital anomalies (P &gt; 0.05, all). As compared to generalized epilepsy, focal epilepsy was associated with younger age (p &lt; 0.001), lower income quartile (p = 0.013), tobacco smoking during pregnancy (p = 0.037) and illicit drug use (p &lt; 0.001). Women with focal epilepsy were more likely than those with generalized epilepsy to be covered by Medicaid and less likely to be covered through Medicare or private insurance (p &lt; 0.001). No significant differences were observed regarding other maternal characteristics.</div><div>Women with focal epilepsy are at a higher risk of delivery through cesarean section than those with generalized epilepsy. The reason why remains unclear. Reassuringly, other pregnancy complications are not increased by generalized as opposed to focal epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110640"},"PeriodicalIF":2.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating microRNAs as potential biomarkers in pediatric epilepsy: a pilot study","authors":"Beata Rzepka-Migut ,&nbsp;Celina Kruszniewska-Rajs ,&nbsp;Magdalena Bugowska ,&nbsp;Marcela Krzempek ,&nbsp;Joanna Gola ,&nbsp;Pasquale Striano ,&nbsp;Justyna Paprocka","doi":"10.1016/j.yebeh.2025.110631","DOIUrl":"10.1016/j.yebeh.2025.110631","url":null,"abstract":"<div><h3>Objective</h3><div>Epilepsy is among the most prevalent neurological disorders in children, yet its diagnosis remains largely subjective and reliant on clinician expertise. This highlights the need for objective, minimally invasive biomarkers to support early diagnosis and predict drug resistance. Circulating microRNAs (miRNAs) in whole blood present a promising avenue as potential diagnostic and prognostic biomarkers for pediatric epilepsy. This study explores the relationship between selected miRNA expression levels and clinical characteristics in children with epilepsy.</div></div><div><h3>Methods</h3><div>A literature review identified five miRNAs with high potential as biomarkers for drug-resistant epilepsy based on studies of the adult population. Quantitative RT-PCR (RT-qPCR) assays were employed to measure miRNA levels in whole blood and assess correlations with clinical characteristics. This pilot study, conducted from June to December 2023, analyzed 109 of the 115 collected blood samples.</div></div><div><h3>Results</h3><div>Correlation analysis revealed significant relationships between miR-142-3p, miR-194-5p, and miR-342-5p expression levels with sex, miR-142-3p and miR-342-5p expression levels with the age of seizure onset, and miR-342-5p with family history. Additionally, miR-233-3p expression showed a statistically significant correlation with EEG abnormalities. The analysis did not demonstrate the potential of the selected miRNAs as valuable biomarkers.</div></div><div><h3>Significance</h3><div>Differences in epilepsy etiology between pediatric and adult populations, along with age and disease duration-dependent miRNA expression, suggest that adult-based findings may not be directly applicable to children. Further research in pediatric cohorts is essential to establish miRNAs as reliable biomarkers for pediatric epilepsy diagnosis and prognosis.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"171 ","pages":"Article 110631"},"PeriodicalIF":2.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}