Epilepsy & Behavior最新文献

{"title":"Use of intrathecal rituximab in autoimmune epilepsy: A retrospective study.","authors":"Christina Wombles, Emilyn Ballard, Holly Skinner, Angel Claudio, Ki Hyeong Lee, Mahammed Z Khan Suheb, Okorie Okorie, Amay Parikh, Raad Bassel, Elakkat D Gireesh","doi":"10.1016/j.yebeh.2025.110280","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110280","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune encephalitis (AE) is a significant challenge in neurological practice, often proving refractory to conventional treatments. It typically manifests with recurrent seizures or status epilepticus, necessitating early diagnosis and tailored therapy for optimal outcomes. Early institution of effective treatment has been reported to reduce the mortality and morbidity associated with this condition. A subpopulation presenting with acute seizures due to autoimmune encephalitis later develop chronic epilepsy, which can be refractory to conventional modes of treatments. In addition, there is a group of chronic epilepsy patients who did not have acute symptomatic seizures who have autoimmune antibodies suggesting an immunological origin of their seizures. This study aims at evaluating the use of rituximab administered intrathecally, for treating these patients, taking pharmacodynamic properties into account.</p><p><strong>Materials and methods: </strong>We retrospectively evaluated the efficacy and safety of intrathecal rituximab (ITR) in 15 patients with autoimmune-related epilepsy (9 of them with acute presentation with seizures and 6 with chronic intractable epilepsy). The nature of these seizures, laboratory findings, imaging and EEG findings were compared over the course of treatment and follow up.</p><p><strong>Results: </strong>No significant long term side effects related to administration of ITR were noted in the 15 patients reported in this series. Improvement was noted in seizure control in the majority of the patients, especially in the acute presentation category, although definitive conclusions about efficacy could not be made since these patients were also receiving additional modes of therapies. Better seizure control was noted in all patients in 12 months follow up.</p><p><strong>Conclusions: </strong>Our findings underscore the safety of intrathecal rituximab in treating autoimmune-related status epilepticus and refractory epilepsy related to autoimmune etiology.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110280"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for depression, anxiety, and suicidality in outpatients of a tertiary epilepsy center: How frequent are increased scores and what is recommended?","authors":"Anne Hagemann, Izumi Kuramochi, Christian G Bien, Christian Brandt","doi":"10.1016/j.yebeh.2025.110289","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110289","url":null,"abstract":"<p><strong>Objective: </strong>Psychiatric comorbidities are frequent in people with epilepsy (PWE) or psychogenic nonepileptic seizures (PNES), and the use of validated screening instruments to identify respective symptoms is recommended. Our aim was to investigate the recommendations resulting from routine screening for depression, anxiety and suicidality with the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and the Generalized Anxiety Disorder Scale (GAD-7) in the outpatient clinic of a tertiary epilepsy center.</p><p><strong>Methods: </strong>We retrospectively analyzed NDDI-E and GAD-7 scores (German versions) of 264 outpatients at a tertiary epilepsy center and extracted recommendations regarding psychopathology from the outpatient letters.</p><p><strong>Results: </strong>The screening revealed a likely major depression (NDDI-E ≥17) in 15.2% of PWE (without PNES, 30/197) and an NDDI-E score ≥17 in 51.2% of patients with PNES ± epilepsy (21/41), moderate to severe symptoms of generalized anxiety (GAD-7 ≥10) in 20.3% of PWE (40/197) and 56.1% of patients with PNES (23/41), and a high risk of suicidality (NDDI-E item 4 ≥3) in 8.1% of PWE (16/197) and in 24.4% of patients with PNES (10/41). The most frequently given recommendations regarding depression or anxiety were a psychiatric/psychotherapeutic treatment for PWE and an admission to the psychotherapy ward of the epilepsy center for patients with PNES. No evidence for active suicidal tendencies was found in any of the patients with a positive screening for suicidality.</p><p><strong>Conclusion: </strong>Routine screening with NDDI-E and GAD-7 for depression, anxiety and suicidality is efficient and feasible and leads to individual recommendations for further assessment and treatment.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110289"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of people with epilepsy in their professional development and daily working life: An exploratory study.","authors":"Leonie Reckin, Sarah Jeschke, Felix von Podewils, Janek Gießler, Silke Schmidt-Schuchert, Samuel Tomczyk, Thilo Bertsche, Martina P Neininger, Astrid Bertsche","doi":"10.1016/j.yebeh.2025.110285","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110285","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective of this exploratory study was to examine the current situation of people with epilepsy (PWE) in the German labor market and how epilepsy affects their daily working life.</p><p><strong>Methods: </strong>From June 2023 to March 2024, we conducted an exploratory online survey in adult PWE in Germany.</p><p><strong>Results: </strong>The online survey was completed by 193 PWE (median age: 40.5 years; Q25/75: 27/53; 62 % female). The participants reported the following effects of their diagnosis on their professional lives: Experiencing reduced work performance due to perceived adverse drug reactions (102/193; 53 %), worrying often about the professional future (93/193; 48 %), and perceiving every-day work or school life to be more challenging because of the diagnosis (90/193; 47 %). Of the 81 participants who were diagnosed before finishing school, 26/81 (32 %) could not pursue their initial career aspirations after receiving their diagnosis. Of the PWE who were diagnosed during their vocational or academic training, 3/35 (9 %) had to specialize differently in their field of training, and 10/35 (29 %) were forced to stop their training. 10/77 (13 %) PWE who were diagnosed during their professional life could not keep their job following the diagnosis.</p><p><strong>Conclusion: </strong>According to self-reports, one of the main challenges faced by adult PWE is the deterioration of work performance due to perceived adverse drug reactions. They also perceived a major mental strain regarding their professional future because of the diagnosis. Moreover, they felt considerably limited in their career choices, especially if they were diagnosed early in life.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110285"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of quantitative EEG markers for predicting outcome after the initial treatment with levetiracetam monotherapy in newly diagnosed epilepsy.","authors":"Felix Zahnert, Pieter van Mierlo, Lena Habermehl, Llenalia Garcia, Karim Malki, Susanne Knake","doi":"10.1016/j.yebeh.2025.110284","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110284","url":null,"abstract":"<p><strong>Objective: </strong>To develop a predictive model for the classification of seizure freedom under first-line monotherapy with levetiracetam in patients with newly diagnosed epilepsy.</p><p><strong>Methods: </strong>Clinical data and routine EEG recordings of patients with newly diagnosed epilepsy who were started on a first-line monotherapy with levetiracetam were analyzed retrospectively. EEG had been acquired prior to the initiation of treatment in all patients. Patients who had experienced no further seizures until the last follow-up were labeled as seizure-free. Spectral EEG features (band power, peak power, and peak frequency) and functional connectivity were computed in each patient and, together with clinical data, formed the input features for the classification procedure. The BiMM-forest algorithm was used for classification and 5-fold cross-validation was conducted to evaluate the model performance.</p><p><strong>Results: </strong>Seventy-four patients were analyzed (43 (58.1 %) female, 43/74 seizure-free. The mean classification accuracy was 75.5 % (95 %-CI = 46.1-92.4 %). The most predictive features for seizure-freedom were increased right frontal delta energy and delta peak energy as well as decreased central delta energy in the first routine EEG.</p><p><strong>Significance: </strong>While significant above-chance predictions were not achieved in this study, a promising framework for the classification of treatment response on first-line monotherapy with levetiracetam based on pre-treatment EEG data alone was provided. Although negative, our results show trends that should encourage future, larger studies to develop EEG-based frameworks for the prediction of treatment response under specific anti-seizure medications.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110284"},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The awareness, attitudes and knowledge of pediatricians in Tamil Nadu India of sudden unexpected death in epilepsy (SUDEP) and epilepsy related risks: A cross-sectional study.","authors":"Nandan Ravichandra, Narmada Ashok, Virupakshi Jalihal, Janani Sankar, Joanne McCabe, Ramya Sekar, Rohini Rattihalli, Rohit Shankar","doi":"10.1016/j.yebeh.2025.110286","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110286","url":null,"abstract":"<p><strong>Background: </strong>Sudden Unexpected Death in Epilepsy (SUDEP) in epilepsy is recognised to be equally common in adults and in children and young people (CYP). There is higher prevalence of epilepsy in lower- and middle-income countries (LMICs) compared to high income countries (HIC) however research in SUDEP is limited in LMICs such as India particularly in CYP.</p><p><strong>Objective: </strong>To explore SUDEP awareness and attitudes to communication to CYP and their carers/parents by pediatricians in Tamil Nadu, India, one of the 28 states, with 80 million population.</p><p><strong>Methods: </strong>A cross-sectional online survey of Likert response questions using validated themes, was circulated among the paediatric doctors fraternity in Tamil Nadu, India. Non-discriminatory exponential snowballing technique leading to convenience non-probability sampling was used. The inquiry involved SUDEP-related topics including the awareness, knowledge, need for and importance of counselling. Descriptive statistics were used for analysis.</p><p><strong>Results: </strong>Out of the 150 consenting participants, a majority were males (60.0 %), had more than 10 years of practice (80.7 %), were private practitioners (51.3 %) and working in urban areas (94 %). Over a third (35 %) did not know of SUDEP, while less than half of the participants (40.7 %) had ever counseled CYP and/or their carers on SUDEP. Nearly three quarters (73.3 %) recognised the need for training on SUDEP risk and communication.</p><p><strong>Conclusion: </strong>There is a significant lack of SUDEP awareness and knowledge among pediatricians in Tamil Nadu India which is likely to be the case across much of India. Virtual training and education could help bridge the knowledge gap.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110286"},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Temporal lobe encephaloceles: Electro-clinical characteristics and seizure outcome after tailored lesionectomy\".","authors":"Alessandra Burini, Elisa Visani, Fabio Martino Doniselli, Valeria Cuccarini, Rita Garbelli, Gianluca Marucci, Dalia De Santis, Giuseppe Didato, Francesco Deleo, Chiara Pastori, Andrea Stabile, Flavio Villani, Michele Rizzi, Luca Girardi, Marco de Curtis, Roberta Di Giacomo","doi":"10.1016/j.yebeh.2025.110282","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110282","url":null,"abstract":"","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110282"},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To what extent does status epilepticus contribute to brain damage in the developmental and epileptic Encephalopathies.","authors":"Nicola Specchio, Stéphane Auvin","doi":"10.1016/j.yebeh.2025.110271","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110271","url":null,"abstract":"<p><p>This paper is based on a presentation made at the 9th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures in April 2024. Status Epilepticus (SE) is a neurological emergency involving prolonged seizures that disrupt brain function and may cause severe, long-term neurological damage. Developmental and Epileptic Encephalopathies (DEEs), a group of severe genetic disorders with early-onset epilepsy, often exhibit SE episodes that compound their inherent cognitive and developmental challenges. In patients with DEEs, SE may intensify excitotoxicity, metabolic strain, and neuroinflammatory processes, exacerbating developmental delays and cognitive deficits. SE episodes in DEEs frequently resist conventional anti-seizure medications, posing heightened risks of progressive neurological decline and mortality. This paper explores how SE contributes to worsening neurodevelopmental outcomes in DEEs, particularly through sustained structural and functional brain alterations observed in human neuroimaging and animal models. Findings from clinical studies and neuroimaging highlight SE's role in structural damage, including cortical atrophy, hippocampal sclerosis, and gray matter loss. Rodent models replicate SE through chemical or electrical induction, providing insights into SE-induced neurodegeneration, network reorganization, especially in critical areas like the hippocampus, which is more known, however few of scientists look that much outside it. The models reveal a progressive cycle where recurrent SE episodes increase brain excitability, predisposing to further seizures and cumulative developmental impairment. Moreover, genetic animal models of DEEs suggest that early-life seizures exacerbate the severity of the epilepsy phenotype and neurocognitive deficits. This paper underscores the need for advanced, individualized therapies to manage SE in DEE patients and prevent recurrence, aiming to minimize long-term neurological and developmental sequelae.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110271"},"PeriodicalIF":2.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the road ahead: Assessing international guidelines for commercial drivers with epileptic seizures.","authors":"Liam Mulcahy, Nicholas Lawn, John Dunne","doi":"10.1016/j.yebeh.2025.110287","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110287","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the availability and consistency of commercial driving eligibility criteria for patients with seizures.</p><p><strong>Methods: </strong>We systematically evaluated commercial driver's license regulations for patients with epilepsy, first acute symptomatic seizure and first unprovoked seizure in different countries. Government driving authority websites and published guidelines were accessed and if not available, local neurologists were contacted.</p><p><strong>Results: </strong>Information on commercial driving eligibility was available for 112 countries: 85 (76 %) via government websites or published guidelines and 27 (24 %) via direct contact with local neurologists. For epilepsy, 85 countries had clear guidelines: 42 countries requiring a seizure-free period of between 5 and 10 years, 43 applying a lifetime ban. Twenty-seven responding countries had no guidelines. For first acute symptomatic seizure (information available for 101 countries), 33 countries either required an individualised assessment or specified a seizure-free period ranging between 6 months and 10 years, 38 had a lifetime ban and 30 had no guidelines. For first unprovoked seizure (information available for 103 countries) 35 countries required seizure freedom for 1 to 10 years, 38 enforced a lifetime ban and 30 had no guidelines. There was considerable variation in the requirements for MRI, EEG, treatment with anti-seizure medication, and/or neurologist input.</p><p><strong>Conclusions: </strong>A marked lack of uniformity in commercial vehicle license guidelines exists for patients with seizures, likely in part reflecting the paucity of long-term data to inform evidence-based policy.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110287"},"PeriodicalIF":2.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between caregiver burden and life satisfaction in caregivers of individuals with epilepsy: An example in eastern Turkey.","authors":"Gülden Atan, Fatma Gündüz Oruç, Kemal Atan","doi":"10.1016/j.yebeh.2025.110275","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110275","url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to investigate the relationship between caregiver burden and life satisfaction among caregivers of individuals with epilepsy.</p><p><strong>Methods: </strong>This descriptive and cross-sectional study was conducted with 210 caregivers at a university hospital located in Van, a province in eastern Türkiye. A personal information form prepared by the researcher based on literature, along with The Caregiver Burden Scale and Life Satisfaction Scale, was used to collect data. Descriptive statistics including frequency, percentage, mean, and standard deviation were utilized. Kurtosis and Skewness coefficients were used to analyze the normal distribution of the data. The relationships between the dimensions determining the levels of the scales for caregivers were examined using Pearson correlation and linear regression analyses. Additionally, t-tests, one-way analysis of variance (ANOVA), and post hoc analyses (Tukey, LSD) were employed. A significance level of p < 0.05 was accepted.</p><p><strong>Results: </strong>The mean total score for caregiver burden among the participants was found to be 35.433 ± 11.480. The mean total score for life satisfaction was determined to be 11.386 ± 2.972. A significant relationship was found between the caregiver burden and life satisfaction scores of the caregivers of individuals with epilepsy participating in the study (r = -0.333; p = 0.000 < 0.05). It was determined that the level of caregiver burden decreases the level of life satisfaction (ß=-0.333).</p><p><strong>Conclusion: </strong>It was determined that relatives of patients with epilepsy experience high levels of caregiver burden. It was also determined that caregiver burden is related to sociodemographic factors such as the caregiver being 41 years of age or older, literate, married, low-income, and the patient's spouse. In the same study, it was also determined that as the total caregiver burden score increased, the total life satisfaction score decreased.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110275"},"PeriodicalIF":2.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A computer-assisted rehabilitation program improves self-management, cognition, and quality of life in epilepsy: A randomized controlled trial.","authors":"Ulku Saygili Duzova, Zuhal Seflek, Fettah Eren, Serefnur Ozturk, Murat Faruk Tutar","doi":"10.1016/j.yebeh.2025.110277","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110277","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the impact of a computer-assisted rehabilitation program on self-management, cognitive function, and quality of life in people with epilepsy (PwE).</p><p><strong>Methods: </strong>A randomized controlled trial was conducted with 44 PwE (22 intervention, 22 control) at a university hospital's neurology clinic. The intervention group received 12 sessions of the RehaCom program (45 min/session, twice a week for six weeks). Data were collected using the \"Quality of Life in Epilepsy Inventory (QOLIE)\", \"Epilepsy Self-Management Scale (ESMS)\", and \"Moxo test\" before and after the intervention.</p><p><strong>Results: </strong>The intervention group showed significant improvements in attention and timing dimensions of the MOXO test and reductions in hyperactivity symptoms compared to the control group (p < 0.05). ESMS scores, including overall self-management, information management, lifestyle management, and safety management sub-dimensions, significantly increased. Similarly, QOLIE scores, particularly in cognitive functioning, emotional well-being, and energy/fatigue, improved, while seizure worry scores decreased (p < 0.001).</p><p><strong>Significance: </strong>The computer-assisted rehabilitation program enhanced self-management, quality of life, attention, and responsiveness while reducing impulsivity and hyperactivity symptoms in PwE.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"164 ","pages":"110277"},"PeriodicalIF":2.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}