Epilepsy & Behavior最新文献

{"title":"Evaluation and management of non-epileptic (functional) seizures: Lessons learned","authors":"Ryan Van Patten ,&nbsp;Jason Richards ,&nbsp;Andrew S. Blum ,&nbsp;W. Curt LaFrance Jr.","doi":"10.1016/j.yebeh.2025.110398","DOIUrl":"10.1016/j.yebeh.2025.110398","url":null,"abstract":"<div><div>In this article focusing on patients with non-epileptic (functional) seizures (NES/FS), senior and rising academicians discuss lessons learned over decades of clinical practice, teaching, and research in the field. Lessons include that non-epileptic (functional) seizures (NES/FS) can be reliably differentiated from epilepsy and diagnosed by a trained neurologist/epileptologist using video EEG long-term monitoring in the seizure monitoring unit. We note that some patients have concurrent NES/FS and epilepsy, meaning that clinicians should carefully document each seizure and teach the patient to differentiate epileptic from non-epileptic events. Neuropsychiatric and neuropsychological evaluations can inform treatment in patients with NES/FS, particularly given the need to comprehensively assess and understand diverse neurological, psychiatric, cognitive, and medical symptoms. Finally, evidence-based psychotherapies for NES/FS include cognitive behavioral therapy and neurobehavioral therapy, which can be administered by a trained seizure counselor.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"167 ","pages":"Article 110398"},"PeriodicalIF":2.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal functional connectivity of paracingulate gyrus in patients with temporal lobe epilepsy-comorbid sleep disorders","authors":"Kangrun Wang ,&nbsp;Yueyao Chen ,&nbsp;Wen Chai ,&nbsp;Chaorong Liu ,&nbsp;Langzi Tan ,&nbsp;Jialinzi He ,&nbsp;Xianghe Liu ,&nbsp;Ge Wang ,&nbsp;Min Zhang ,&nbsp;Lili Long ,&nbsp;Bo Xiao ,&nbsp;Fangfang Xie ,&nbsp;Yanmin Song","doi":"10.1016/j.yebeh.2025.110408","DOIUrl":"10.1016/j.yebeh.2025.110408","url":null,"abstract":"<div><div>Abnormalities in paracingulate gyrus (PCG) were found in both patients with temporal lobe epilepsy and patients with sleep disorders. These abnormalities include reduced functional connectivity between PCG and other brain regions, abnormal activity and reduced volume of PCG. PCG may be associated with comorbid sleep disorders in patients with temporal lobe epilepsy (TLE). This study aimed to explore the relationship between abnormal PCG function and comorbid sleep disorders in patients with TLE. We used Pittsburgh Sleep Quality Index −8/9 to divide fifty-eight patients into a group with sleep disorders and group without sleep disorders. Using the PCG as the seed, we examined the task-based seed-to-voxel functional connectivity identified by group-independent component analysis. Compared with the normal sleep group<strong>,</strong> we observed longer disease duration, higher frequency of seizures, higher Self-Rating Anxiety Scale scores in the comorbidity group (p &lt; 0.05). During the verbal fluency character task, functional connectivity from the PCG to the right frontal and parietal regions was decreased in the comorbidity group (p &lt; 0.05, FDR-corrected). Sensitivity analyses confirmed that our conclusions were not affected by factors such as laterality or hippocampal sclerosis. These abnormalities reveal brain lesions in patients with TLE comorbid sleep disorders, which may contribute to the pathogenesis of the comorbidity and be related to patients’ preserved verbal functions.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"168 ","pages":"Article 110408"},"PeriodicalIF":2.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term seizure reduction in generalized epilepsy after anterior nucleus of the thalamus stimulation","authors":"Zachary L Bernstein ,&nbsp;Ashley LB Raghu ,&nbsp;Amir P Divanbeighi Zand ,&nbsp;Ammar Kheder ,&nbsp;Robert E Gross","doi":"10.1016/j.yebeh.2025.110389","DOIUrl":"10.1016/j.yebeh.2025.110389","url":null,"abstract":"<div><h3>Introduction</h3><div>In 2018 the FDA approved the use of anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS) for focal epilepsy in response to the results of the Stimulation of the Anterior Nucleus of Thalamus for Epilepsy (SANTÉ) double-blind randomized controlled trial. While generalized epilepsy (GE) was never assessed in this trial, subsequent follow up clarified that focal to bilateral tonic-clonic seizures were reduced in these subjects. In rare cases ANT DBS has nonetheless been pursued for patients with GE.</div></div><div><h3>Methods</h3><div>We report a 27-year-old male with idiopathic GE who was successfully treated with ANT DBS. Prior to DBS, the patient typically had three or four generalized tonic-clonic seizures (GTCS) per week, amongst other seizures, and was refractory to both medication and vagal nerve stimulation (VNS). We also systematically reviewed the literature to understand the extent to which ANT DBS has been used in GE, under what circumstances, and with what results.</div></div><div><h3>Results</h3><div>Five years since the introduction of ANT DBS, the patient has remained free of GTCS. Over this time, other seizures were also markedly reduced. For the systematic review, a comprehensive literature search using PubMed, Cochrane, and Google Scholar identified 23 GE patients treated with ANT DBS across 13 publications. 13 patients had patient-specific seizure outcomes reported. Clinical findings, seizure characteristics, and outcomes were summarized, demonstrating that ANT DBS surgery typically occurred after failed VNS and was usually effective, including 3 patients who became free of GTCS.</div></div><div><h3>Conclusion</h3><div>This anecdotal evidence of effectiveness suggests that some GE networks can be modulated by high-frequency stimulation at the ANT node. When established therapies have failed, ANT DBS is a therapeutic option, but the treatment requires further structured research in treating GE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"167 ","pages":"Article 110389"},"PeriodicalIF":2.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do anxiety, depression, and stigma affect quality of life in people with epilepsy?","authors":"Gülşah Çamcı ,&nbsp;Hatice Karabuğa Yakar ,&nbsp;Sıdıka Oğuz ,&nbsp;Heycan Erdoğan","doi":"10.1016/j.yebeh.2025.110399","DOIUrl":"10.1016/j.yebeh.2025.110399","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety, depression, and stigma can significantly affect the quality of life of people with epilepsy. This study was carried out to determine the relationship between these factors.</div></div><div><h3>Method</h3><div>The study was conducted with 325 people with epilepsy admitted to the neurology outpatient clinic of a training and research hospital in Istanbul, Türkiye. Data were collected using a General Information Form, the Depression in Neurological Disorders Scale-Epilepsy (NDDI-E), Generalized Anxiety Disorder-7 Scale (GAD-7), Epilepsy Self-Stigma Scale (ESSS), and Quality of Life in Epilepsy Scale (QOLIE-31). Data were analyzed using the Student’s <em>t</em>-test, one-way ANOVA, Pearson correlation, and multiple linear regression test.</div></div><div><h3>Results</h3><div>Of the included patients, 60.9 % were female, 61.5 % were married, and 84.3 % had generalized seizures. The mean anxiety score was 16.80 ± 6.13, and 13.5 % of patients had mild anxiety, 27.7 % had moderate anxiety, and 58.8 % had severe anxiety. The mean depression score was 14.07 ± 3.58, and 39.7 % of the patients were at risk for depression. The mean total score for stigma was 14.29 ± 5.67, and the mean total score of the quality of life scale was 47.54 ± 11.36. Quality of life decreased with increasing levels of depression (r = -0.418; p &lt; 0.001), anxiety (r = -0.292; p &lt; 0.001), and stigma (r = -0.224; p &lt; 0.001). Depression, anxiety, stigma, and seizure frequency explained 25 % of the total variance in quality of life.</div></div><div><h3>Conclusion</h3><div>There was a negative correlation between anxiety, depression, stigma, and quality of life. These factors, as well as seizure frequency, were statistically significant predictors of quality of life in people with epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"167 ","pages":"Article 110399"},"PeriodicalIF":2.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric comorbidities predict seizure recurrence in newly treated adults with epilepsy","authors":"Ke Tang ,&nbsp;Rui Zhong ,&nbsp;Nan Li ,&nbsp;Jing Li ,&nbsp;Xinyue Zhang ,&nbsp;Weihong Lin ,&nbsp;Jing Yang ,&nbsp;Guangjian Li","doi":"10.1016/j.yebeh.2025.110409","DOIUrl":"10.1016/j.yebeh.2025.110409","url":null,"abstract":"<div><h3>Objective</h3><div>At least 30 % to 40 % of patients newly treated for epilepsy experience further seizures despite initiation of appropriate antiseizure medication (ASM) treatment. This study aimed to identify clinically useful predictors of seizure recurrence in newly treated adults with epilepsy which would have major clinical benefits.</div></div><div><h3>Methods</h3><div>This work is a prospective cohort study conducted in Northeast China between June 2017 and May 2022. At enrolment, we collected information about demographics, clinical characteristics, and psychiatric comorbidities in newly treated adults with epilepsy. All patients were followed for 12 months for further seizures. Predictors of seizure recurrence were identified using logistic regression analyses.</div></div><div><h3>Results</h3><div>A total of 836 newly treated adults with epilepsy were included in the final analysis. During follow-up, 362 (43.3 %) patients experienced at least one seizure recurrence, and 474 (56.7 %) entered seizure remission. Multivariable analysis showed that the odds of patients with depression having seizure recurrence were 1.74 times greater than those of patients without depression (Adjusted OR 1.74, 95 % CI 1.21–2.51). Similarly, the odds of patients with anxiety having seizure recurrence were 1.69 times greater than those of patients without anxiety (Adjusted OR 1.69, 95 % CI 1.21–2.37). Other Predictors of seizure recurrence included &gt;5 seizures prior to treatment, brain MRI lesion, EEG epileptiform discharges.</div></div><div><h3>Conclusion</h3><div>We found that psychiatric comorbidities at baseline increase the risk of seizure recurrence in newly treated adults with epilepsy. Future studies are required to clarify the mechanisms underlying the links among psychiatric comorbidities and epilepsy. Furthermore, our findings might inform prospective studies investigating whether psychiatric treatment reduces the risk of seizure recurrence in these patients.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"168 ","pages":"Article 110409"},"PeriodicalIF":2.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing efficacy and safety: The dual impact of antiseizure medications on the developing brain","authors":"M.S. Oliveira ,&nbsp;R.A. Fernandes ,&nbsp;L.S. Pinto ,&nbsp;F.A. Moreira ,&nbsp;O.W. de Castro ,&nbsp;V.R. Santos","doi":"10.1016/j.yebeh.2025.110400","DOIUrl":"10.1016/j.yebeh.2025.110400","url":null,"abstract":"<div><div>The number of neurons in the developing brain is greater than typically found in adulthood, and the brain possesses delicate mechanisms to induce the death of excess cells and refine neural circuitry. The correct tuning between the processes of neuronal death and survival generates a mature and functional brain in its complexity and plastic capacity. Epilepsy is a highly prevalent neurological condition worldwide, including among young individuals. However, exposure to the main treatment approaches, the long-term use of Antiseizure Medication (ASM), during the critical period of development can induce a series of changes in this delicate balance. Acting by various mechanisms of action, ASMs may induce an increase in neuronal death, something that translates into deleterious neuropsychiatric effects in adulthood. Several investigations conducted in recent years have brought to light new aspects related to this dynamic, yet many questions, such as the cellular mechanisms of death and the pathophysiology of late effects, still have unresolved elements.</div><div>In this review, we aimed to explore the mechanisms of action of the most widely used ASMs in the treatment of neonatal epilepsy, the broad aspects of neuronal death in the developing brain and the repercussions of this death and other effects in adulthood. We review the evidence indicating a relationship between exposure to ASMs and the manifestation of associated psychiatric comorbidities in adulthood and discuss some possible mechanisms underlying the induction of this process by morphological and physiological changes in the related behaviors.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"167 ","pages":"Article 110400"},"PeriodicalIF":2.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of self-management education on quality of life in patients with epilepsy: A systematic review and meta-analysis","authors":"Yanfang Huang ,&nbsp;Min Zhang ,&nbsp;Tengteng Liu","doi":"10.1016/j.yebeh.2025.110393","DOIUrl":"10.1016/j.yebeh.2025.110393","url":null,"abstract":"<div><h3>Background</h3><div>Self-management education, as a non-pharmacological intervention, aims to help epilepsy patients better control their condition and improve their quality of life. While some studies have shown that self-management education is beneficial for epilepsy patients, its specific effects still require systematic evaluation.</div></div><div><h3>Objective</h3><div>This study aims to comprehensively assess the impact of self-management education on the quality of life and recurrence frequency of epilepsy patients through a systematic review and <em>meta</em>-analysis.</div></div><div><h3>Methods</h3><div>This study systematically reviewed literature on self-management education for epilepsy patients from 2014 to 2024. Computer searches were conducted in PubMed, Wiley Library, EMBASE, Web of Science, Cochrane Central, and CNKI databases, covering the period from January 1, 2014, to August 31, 2024, to identify relevant randomized controlled trials (RCTs). Two independent reviewers screened the literature, extracted data, and assessed the risk of bias according to predefined criteria. The primary outcome measures included scores from the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression, the Epilepsy Self-Efficacy Scale (ESES), the Quality of Life in Epilepsy Inventory (QOLIE-31), the Medication Event Monitoring System (MEMS), the Patient Health Questionnaire (PHQ-9), and the Epilepsy Knowledge Questionnaire (EKP).</div></div><div><h3>Results</h3><div>A total of 9 RCTs involving 1094 patients were included after searching six databases. The results showed that self-management education significantly improved the quality of life of epilepsy patients (SMD = 0.56, 95 % CI [-0.05; 0.18]) and significantly reduced anxiety (SMD = −0.41, 95 % CI [-0.58; −0.23]) and depression symptoms (SMD = −0.40, 95 % CI [-0.76; −0.05]). Additionally, self-management education significantly enhanced patients’ self-efficacy in managing seizures (SMD = 0.32, 95 % CI [0.12; 0.52]).</div></div><div><h3>Conclusion</h3><div>Self-management education can effectively improve the quality of life and mental health of epilepsy patients, enhancing their ability to cope with the disease, and provides strong evidence for clinical practice. However, due to the high heterogeneity among studies, more high-quality RCTs are needed to further validate these findings.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"168 ","pages":"Article 110393"},"PeriodicalIF":2.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicranial focal cortex stimulation for minimally invasive neuromodulation of the epileptogenic region: A review","authors":"Andreas Schulze-Bonhage ,&nbsp;Victoria San Antonio-Arce ,&nbsp;Sotirios Kalousios ,&nbsp;Eva Martinez-Lizana ,&nbsp;Volker Arnd Coenen ,&nbsp;Martin Hirsch","doi":"10.1016/j.yebeh.2025.110390","DOIUrl":"10.1016/j.yebeh.2025.110390","url":null,"abstract":"<div><div>Epicranial focal cortex stimulation (FCS) is a new type of neurostimulation for pharmacoresistant focal epilepsy, which has recently been CE-certified for treatment of European patients. Stimulation is performed via an epicranially placed five-contact electrode array, which applies high frequency stimulation and DC-like cathodal stimulation to the individual epileptogenic brain region. Stimulation at appropriate intensities is not perceived by patients, and first evidence from two prospective unblinded clinical trials suggests excellent tolerability of both, subgaleal implantation and transcranial stimulation. In epilepsies arising from the dorsolateral brain convexity, FCS resulted in a median seizure reduction of &gt;50 % after 6 months which further increased to &gt;60 % after 2 years. This compares favorably to more invasive neurostimulation approaches.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"168 ","pages":"Article 110390"},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological outcome after surgery of frontal lobe epilepsy in children with good seizure outcome","authors":"S. Blanchet ,&nbsp;C. Bulteau ,&nbsp;S. Perguilhem ,&nbsp;A. Salaun ,&nbsp;S. Ferrand-Sorbets ,&nbsp;J. Laschet ,&nbsp;P. Piolino ,&nbsp;I. Jambaqué","doi":"10.1016/j.yebeh.2025.110405","DOIUrl":"10.1016/j.yebeh.2025.110405","url":null,"abstract":"<div><div>One third of children with drug-resistant epilepsy included in surgical programmes have frontal lobe epilepsy. Frontal lobe epilepsy in itself constitutes a high risk of impacting neurocognitive and behavioral development. In this study, we characterized the long-term neuropsychological and behavioral outcomes of children with pharmacoresistant structural focal epilepsy who underwent frontal neurosurgery. The clinical variables that may influence these outcomes were also investigated. A comprehensive neuropsychological evaluation – including a behavioral questionnaire − was administered to 37 children on long-term postoperative follow-up (5.1 years ± 2.9) using the Wechsler Intelligence Scale for Children, Fluency task, Rey-Osterrieth Complex Figure, Trail Making Test, Tower of London, Wisconsin Sorting Card Test and Achenbach Child Behaviour Inventory. To assess executive functions in the youngest children, we administered the junior version of EpiTrack. The clinical characteristics were as follows (mean in years ± standard deviation): Engel I (78 % with among them 96 % without anti-seizure medication), age of onset of seizures (3.5 ± 2.9), preoperative delay (3.9 ± 2.5), neurosurgical age (7.5 ± 3.6), FCD (n = 25) versus LEAT (n = 12) aetiologies. In our series, the children had an average FSIQ (92 ± 17) with a significant difference between VCI which was higher than WMI and PSI. About a third of the children experienced weakness of the executive functions with some difficulties in phonemic verbal fluency and slowness in attentional tasks, and a long execution time in planning, as well as impaired conceptualization and organization capacities. Mild to severe alteration on the Epitrack Junior was found in the majority of the youngest patients although they had a mean FSIQ of 96. At the behavioral level, around a quarter of children reached a pathological score in the attentional, social and anxiety/depression domains. Regarding the effects of clinical variables, we demonstrated that early age at surgery, shorter disease duration and LEAT etiology, were good prognosis factors for neuropsychological outcomes. Early frontal lobe resection followed by good seizure outcome efficiently determines intellectual and neuropsychological trajectory in selected patients. Our results help to better understand the cognitive and behavioral outcomes of this pediatric population, who may benefit from cognitive follow-up and adapted intervention when weaknesses are identified.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"167 ","pages":"Article 110405"},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy associated with chromosomal disorders","authors":"Maria A. Montenegro ,&nbsp;Silvia Vincentiis ,&nbsp;Kette D. Valente","doi":"10.1016/j.yebeh.2025.110360","DOIUrl":"10.1016/j.yebeh.2025.110360","url":null,"abstract":"<div><div>Chromosomal disorders are multisystemic conditions frequently presenting developmental delay and epilepsy as primary neurological symptoms. Epilepsy in these syndromes significantly impacts morbidity, quality of life, and neurodevelopment. Angelman syndrome, ring chromosome 20, Down syndrome, Dup15q syndrome, and others display suggestive electroclinical profiles that may help diagnose and treatment. Understanding the associated electroencephalographic (EEG) findings is critical for clinicians to tailor interventions and optimize outcomes. This review highlights the prevalence, onset, seizure types, EEG characteristics, and treatment approaches for epilepsy in major chromosomal disorders. Angelman syndrome features epilepsy with atypical absences and myoclonic seizures, often associated with specific EEG patterns such as rhythmic delta activity. Ring chromosome 20 syndrome presents with focal frontal seizures, including non-convulsive <em>status epilepticus</em>. Down syndrome has a biphasic epilepsy distribution, from infantile spasms to late-onset myoclonic epilepsy. Similarly, Dup15q syndrome is marked by drug-resistant epilepsy, with EEG showing beta rhythms and hypsarrhythmia. Knowing the electroclinical patterns associated with chromosomal disorders may improve diagnosis and epilepsy management, which enhances patient care and prognosis accuracy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"167 ","pages":"Article 110360"},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}