Epilepsy & Behavior最新文献

{"title":"Corrigendum to \"Adaptive mental health screening in veterans admitted to an epilepsy monitoring unit\". [Epilepsy Behav. 171 (2025) 110628].","authors":"David Engel, Corey Meyer, Sarah Senderling, Esther Fiore, Lina Lee, Jeremiah Lum, Andrea Hildebrand, Marissa Kellogg, Megan Callahan","doi":"10.1016/j.yebeh.2025.110699","DOIUrl":"10.1016/j.yebeh.2025.110699","url":null,"abstract":"","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":" ","pages":"110699"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The facilitators and barriers of emotional well-being in Chinese adolescents with epilepsy based on the PERMA model: A qualitative study.","authors":"Wanyue Fang, Shasha Zhang, Fang Zhang, Wenjun Wei, Shoushan Li","doi":"10.1016/j.yebeh.2025.110687","DOIUrl":"10.1016/j.yebeh.2025.110687","url":null,"abstract":"<p><strong>Objective: </strong>Explore the factors that promote and hinder emotional well-being(EWB) in adolescents with epilepsy(AWE), and provide theoretical evidence for promoting the improvement of EWB in AWEs.</p><p><strong>Method: </strong>Using purposive sampling, semi-structured interviews were conducted with 16 AWEs aged 13-18 years, and data analysis was performed based on the PERMA model.</p><p><strong>Results: </strong>Four subthemes of facilitating factors for EWB in AWEs were identified: positive emotions (positive experiences in daily life), engagement (stage-appropriate feasible goals), relationships (harmonious family relationships, supportive peer relationships, and understanding teachers), and accomplishment (stage-appropriate feasible goals). Four subthemes of barrier factors included: diminished positive emotional experiences (stigma associated with epilepsy), restricted engagement (limitations in physical activities), interpersonal conflicts (discordant social atmosphere), and difficult-to-achieve accomplishments (ineffective emotion regulation strategies and unmanageable academic pressure).</p><p><strong>Conclusion: </strong>Both facilitating and obstructive factors influence EWB in AWEs. Healthcare professionals should focus on leisure activities, interpersonal dynamics, disease awareness, emotion regulation, and academic pressure when developing targeted interventions for patients and their caregivers. These measures aim to enhance patients' sense of meaning and EWB while alleviating epilepsy-related stress.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"110687"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered resting-state functional connectivity in the sleep-wake circuit in juvenile myoclonic epilepsy: A Seed-based fMRI study.","authors":"Jiayao Li, Danlei Wei, Wen Chai, Fangfang Xie, Xianghe Liu, Min Zhang, Sha Huang, Jinxin Peng, Jingwan Feng, Lili Long, Bo Xiao, Kangrun Wang, Yanmin Song","doi":"10.1016/j.yebeh.2025.110786","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110786","url":null,"abstract":"<p><strong>Objective: </strong>Juvenile myoclonic epilepsy (JME) is characterized by myoclonic seizures mostly occurring after awakening, and sleep deprivation is a common predisposing factor. This study aims to investigate the resting-state functional connectivity (rs-FC) of key regions in the sleep-wake circuit in patients with JME, focusing on the suprachiasmatic nucleus (SCN), posterior hypothalamus, and the ascending reticular activating system (ARAS).</p><p><strong>Methods: </strong>This study involved 33 patients with JME and 40 age and gender-matched healthy controls (HCs). All participants underwent sleep and cognitive learning-related neuropsychological scales and resting-state functional magnetic resonance imaging (rs-fMRI), and seed-based functional connectivity analysis was performed on regions within the sleep-wake circuit, including the SCN, posterior hypothalamus, and ARAS nuclei.</p><p><strong>Results: </strong>In patients with JME, significant alterations in rs-FC were observed, including increased connectivity between the left SCN and the left medial superior frontal gyrus (P_FDR-corr = 0.002), and altered connectivity in the laterodorsal tegmental nucleus (LTN), periaqueductal gray (PAG), and parabrachial complex (PBC). LTN seed displayed significant hyperconnectivity with the cluster in the frontal lobe (right superior frontal gyrus, bilateral supplementary motor area, bilateral precentral gyrus, bilateral paracentral lobule), the parietal lobe (bilateral postcentral gyrus, right superior parietal lobule), right superior temporal gyrus, the occipital lobe (bilateral cuneus, bilateral superior occipital gyrus, bilateral calcarine fissure), and midbrain in JMEs (P_FDR-corr< 0.001), and revealed significantly decreased rs-FC with pons (P_FDR-corr< 0.001) compared to HCs. Furthermore, PAG seed showed significant hyperconnectivity with the left red nucleus and the dorsal raphe nucleus (P_FDR-corr< 0.001) compared to HCs. Lastly, PBC seed showed significant hyperconnectivity with pons, and significantly decreased rs-FC with midbrain, cerebellar vermis, and bilateral locus coeruleus (P_FDR-corr< 0.001).</p><p><strong>Conclusions: </strong>The study reveals significant alterations in the functional connectivity of brain regions involved in the sleep-wake circuit in patients with JME, providing valuable information for understanding myoclonic seizures after awakening and seizures triggered by sleep deprivation.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"110786"},"PeriodicalIF":2.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of long-term combination therapy with lacosamide and oxcarbazepine for pediatric patients with focal epilepsy: real-world clinical experience.","authors":"Xueying Wang, Lin Yang, Shaoping Huang, Dan Li, Yu Liu, Yingying Guo, Na Sun, Gaobo Ye, Yonghui Dang","doi":"10.1016/j.yebeh.2025.110718","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110718","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy and safety of the combination of lacosamide (LCM) and oxcarbazepine (OXC) in children with focal epilepsy, either as a dual therapy or in combination with other anti-seizure medications.</p><p><strong>Methods: </strong>We collected clinical data retrospectively from pediatric epilepsy patients treated with both LCM and OXC for at least 6 months at the Department of Pediatrics, Second Affiliated Hospital of Xi'an Jiaotong University, between January 2021 and July 2023. Efficacy and adverse events were investigated.</p><p><strong>Results: </strong>Collectively, 69 pediatric patients were included, with ages ranging from 1 to 18 years. The age at onset of epilepsy varied from 15 days to 14.8 years. Disease duration ranged from 1 month to 14 years. All pediatric patients exhibited focal seizures, with the maximum number of concurrent combined medications being six. The maintenance dose of LCM for all pediatric patients was between 3.8 and 10 mg/kg, while that of OXC was between 15 and 40 mg/kg. Over half of the patients showed a greater than 50 % reduction in seizure frequency during long-term follow-up. The most frequently reported adverse reactions included hyponatremia, headache, dizziness, somnolence, and nausea; no patients experienced rash as an adverse reaction.</p><p><strong>Conclusion: </strong>The combination of LCM and OXC has shown promising efficacy and tolerability in pediatric patients with focal epilepsy. This therapeutic combination is a worthwhile option to consider for patients with focal epilepsy, especially those with underlying structural abnormalities.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"110718"},"PeriodicalIF":2.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated clinico-psychosocial factors of caregiver burden among family caregivers of adults with epilepsy: A cross-sectional study from a Tertiary Care Centre in India.","authors":"Shubhi Nema, Senthil Amudhan, Ravindranadh Chowdary Mundlamuri, Vaishali Dagar, Hemant Kumar Tiwari, Priyanthi Arichandran, Girish Nagaraja Rao","doi":"10.1016/j.yebeh.2025.110789","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110789","url":null,"abstract":"<p><strong>Objective: </strong>Despite the considerable burden of caregiving for persons with epilepsy (PwE), evidence from resource-limited settings remains sparse. This study aimed to assess caregiver burden and its associated factors among caregivers of PwE in a resource-limited setting.</p><p><strong>Methods: </strong>A hospital-based cross-sectional study was conducted in a tertiary care setting in India. Data were collected from primary caregivers of adult PwE through interviews using a comprehensive questionnaire assessing socio-demographics of patients and caregivers, clinical characteristics of PwE, caregiver burden, and associated psychosocial factors (depression, anxiety, and stigma). Descriptive statistics were used to describe the prevalence of caregiver burden, and multivariable linear regression analysis was used to identify associated factors.</p><p><strong>Results: </strong>Among 306 completed interviews, the mean caregiver burden score was 36.8 (SD = 11.8), and 35 % of participants had moderate-to-severe burden. Caregiver burden correlated positively with anxiety (r = 0.7, p < 0.01), depression (r = 0.6, p < 0.01), and stigma (r = 0.6, p < 0.01). In the final model, caregiver burden was significantly higher among caregivers who were married, unemployed, missed more workdays, and frequently visited NFHCPs (Non-Formal Health Care Providers). Psychosocial variables such as anxiety, depression, and stigma were also associated with caregiver burden. Standardized beta coefficients indicated stigma had the strongest association (β = 0.34), followed by anxiety (β = 0.32) and depression (β = 0.19).</p><p><strong>Conclusion: </strong>A substantial proportion of caregivers experienced moderate-to-severe burden, significantly associated with anxiety, depression, and stigma. Targeted interventions addressing caregiver mental health and stigma may reduce burden and improve comprehensive epilepsy care.</p>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"110789"},"PeriodicalIF":2.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a video-based deep learning model for distinguishing epileptic seizures from non-epileptic events in a pediatric cohort","authors":"Ping Ding ,&nbsp;Tinghong Liu ,&nbsp;Jinshan Xu,&nbsp;Liu Yuan,&nbsp;Liwei Zhang,&nbsp;Zhirong Wei,&nbsp;Yuchen Tai,&nbsp;Shuli Liang","doi":"10.1016/j.yebeh.2025.110785","DOIUrl":"10.1016/j.yebeh.2025.110785","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop and validate a video-based deep learning system for distinguishing epileptic seizures (ES) from non-epileptic events (NEE) in a pediatric cohort. Using a prospective validation cohort, we further assessed the diagnostic performance and clinical applicability of the artificial intelligence (AI) model, investigated potential factors contributing to its diagnostic errors, and benchmarked its clinical utility against clinicians grouped by different levels of expertise.</div></div><div><h3>Methods</h3><div>An enhanced multiscale vision transformer was trained on 438 retrospectively collected videos, with benchmark comparisons against MViTv2 and SlowFast architectures. Prospective validation was performed using 130 consecutive videos to assess the diagnostic performance of the AI system against tiered clinician groups (interns, attending physicians, and chief physicians). A generalized linear mixed model (GLMM) was employed to identify factors associated with AI misdiagnosis, with further comparative analysis of diagnostic performance between AI and human clinicians.</div></div><div><h3>Results</h3><div>Our model demonstrated significantly higher accuracy (p = 0.001) and sensitivity (p = 0.004) compared to the MViTv2 model. Although all performance metrics were numerically higher than those of the SlowFast model, these differences did not reach statistical significance. GLMM analysis indicated that event type (motor vs. non-motor) was a significant factor influencing model misclassification (p = 0.020). The model achieved substantially higher diagnostic accuracy for motor events compared to non-motor events (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The video-based AI classifier shows promise as an assistive tool for clinicians in differentiating ES from NEE based on video evidence in a pediatric cohort. Our AI model demonstrated notably effective diagnostic performance for motor events, while its accuracy was more limited for non-motor events.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"Article 110785"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental and epileptic encephalopathies: From current care to future perspectives − insights from epilepsy centres in Lombardy, Italy","authors":"Giuseppe Didato ,&nbsp;Francesca Ragona ,&nbsp;Alice Pompili ,&nbsp;Francesca Beccaria ,&nbsp;Simone Beretta ,&nbsp;Valentina Chiesa ,&nbsp;Valentina De Giorgis ,&nbsp;Giovanni De Maria ,&nbsp;Robertino Dilena ,&nbsp;Ivan Lucio Giordano ,&nbsp;Francesca Labriola ,&nbsp;Monica Lodi ,&nbsp;Cinzia Peruzzi ,&nbsp;Rui Quintas ,&nbsp;Claudio Zucca ,&nbsp;Aglaia Vignoli","doi":"10.1016/j.yebeh.2025.110763","DOIUrl":"10.1016/j.yebeh.2025.110763","url":null,"abstract":"<div><h3>Purpose</h3><div>Developmental and epileptic encephalopathies (DEEs) are complex diseases, requiring specialized expertise from neurologists and dedicated facilities for diagnosis and treatment. Building networks among specialized centres can improve the overall quality of care for patients with DEEs. This study aimed to evaluate the approach to DEEs in different epilepsy centres in Lombardy, Northern Italy.</div></div><div><h3>Methods</h3><div>A panel of experts from Lombardy’s epilepsy centres met in 2023 with the aim of sharing their experiences about DEEs management, specifically Lennox-Gastaut syndrome, Dravet syndrome and Tuberous Sclerosis Complex. This collaborative initiative aimed not only to compare current practices, but also to explore the potential for building stronger networks among specialized centres to improve care pathways for patients with DEEs. Following the meeting, a survey was distributed to the participants to gather quantitative data on diagnostic and treatment approaches, as well as to identify the unmet needs concerning patients with DEEs.</div></div><div><h3>Results</h3><div>The expert panel identified several key issues in the management of DEEs: a) organizational barriers often hinder the implementation of best practices in the clinical management of DEEs; b) due to legislative limitations, the ability to prescribe specific new medications for rare diseases is granted excusively to a subset of referral centres (67%); c) the majority of the involved centres (70%) must refer DEEs patients to other facilities for epilepsy surgery; d) the management of adult patients with DEEs, especially those with psychiatric comorbidities, remains a major challenge.</div></div><div><h3>Conclusions</h3><div>Establishing networks between different referral centres can improve and enhance DEE patients’ management.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"Article 110763"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of interoceptive accuracy in individuals with epilepsy","authors":"Melik Gursoy ,&nbsp;Serkan Aksu ,&nbsp;Semai Bek ,&nbsp;Gulnihal Kutlu","doi":"10.1016/j.yebeh.2025.110765","DOIUrl":"10.1016/j.yebeh.2025.110765","url":null,"abstract":"<div><h3>Objective</h3><div>Interoception, conceptualized as the ability to discern internal bodily signals, is integral to the regulation of emotions, cognitive functioning, and overall physiological well-being. This phenomenon is delineated into three distinct dimensions: accuracy, sensibility, and awareness. The primary aim of our investigation was to evaluate the interoceptive accuracy performances across a spectrum of subjects, including patients with well-managed epilepsy, drug-resistant epilepsy, individuals diagnosed with PNES, patients with a dual diagnosis of PNES and epilepsy (designated as PNES + epilepsy), as well as healthy control participants.</div></div><div><h3>Methods</h3><div>The research encompassed a total of 144 participants, who were systematically classified into five distinct groups. Interoceptive accuracy was assessed utilizing the heartbeat counting task (HCT), while psychological distress was measured through the Patient Health Questionnaire-9 (PHQ-9). Rigorous inclusion and exclusion criteria were implemented to ensure the homogeneity of the sample. Statistical analyses were performed to evaluate the differences across the groups.</div></div><div><h3>Results</h3><div>The coefficients of interoceptive accuracy were markedly superior in the healthy control group (0.843) in comparison to the controlled epilepsy group (0.668), the drug-resistant epilepsy group (0.672), the PNES plus epilepsy group (0.575), and the PNES group (0.582). Nevertheless, no statistically significant differences were identified among the various patient cohorts.</div></div><div><h3>Significance</h3><div>Interoceptive dysfunction is frequently observed in populations afflicted with epilepsy and PNES, underscoring its potential relevance in the pathophysiological framework of these disorders as well as in the formulation of therapeutic interventions. Future inquiries should concentrate on exploring targeted strategies aimed at enhancing interoceptive processing and related clinical outcomes.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"Article 110765"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exacerbation of absence seizures by central prolactin in female taiep rats: An animal model of epilepsy-prone leukodystrophy","authors":"Salvador Hernandez-Alvarado ,&nbsp;Carmen Cortes ,&nbsp;Jose R. Eguibar","doi":"10.1016/j.yebeh.2025.110743","DOIUrl":"10.1016/j.yebeh.2025.110743","url":null,"abstract":"<div><div>Absence seizures are a type of generalized epilepsy characterized by spike-wave discharges (SWDs) in the electroencephalogram (EEG). This condition affects girls more frequently than boys and has a worse prognosis in women during puberty and adulthood. These characteristics of sexual dimorphism and age predominance could be attributed to changes in plasma hormone levels during development, particularly during puberty, which can modulate the cortico-thalamic circuit responsible for generating and sustaining SWDs. Prolactin is a peptide hormone secreted by adenohypophysis, exhibits sexual dimorphism and undergoes an increase during puberty. In this study, we employed female <em>taiep</em> rats, a well-validated animal model of leukodystrophy known as hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC). This model has a sexually dimorphic pattern of SWDs, with males exhibiting greater susceptibility to the condition. The rats were ovariectomized and electrodes were implanted for EEGs and a stainless-steel cannula for administration of rat prolactin via intracerebroventricular (i.c.v.) injection. Five 12-hour EEGs were performed with fixed 48-hour start intervals: the control EEG followed by i.c.v. prolactin administration at doses of 0.5, 1, 2, or 4 μg/2 μL. The frequency of SWDs increased significantly with the 2 and 4 μg/2 μL doses of prolactin. The mean duration of SWDs increased significantly with all doses evaluated, with the greatest effect observed 6 h after 4 μg/2 μL of prolactin, which doubled the mean duration obtained in control conditions. Additionally, prolactin 4 μg/2 μL significantly decreased the latency to the first SWDs. We propose that prolactin is capable of neuromodulating the thalamo-cortical circuit responsible for spike-wave discharges.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"Article 110743"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between self-esteem and social anxiety in adults with epilepsy: the role of seizure frequency","authors":"Fatma Gündüz Oruç ,&nbsp;Gülden Atan","doi":"10.1016/j.yebeh.2025.110764","DOIUrl":"10.1016/j.yebeh.2025.110764","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to determine the self-esteem and social anxiety levels of adult individuals with epilepsy and to examine the moderating effect of seizure frequency on these variables.</div></div><div><h3>Method</h3><div>The study was planned as a descriptive and cross-sectional study. The sample consisted of 307 adults with epilepsy living in Van province in eastern Turkey who met the inclusion criteria. Personal information form, Rosenberg Self-Esteem Scale (RSES), and Social Anxiety Scale Short Form were used to collect the data. Data analysis was performed with SPSS Statistics 27 package program at 95 % confidence level and significance level was accepted as p &lt; 0.05.</div></div><div><h3>Results</h3><div>The mean self-esteem score of the participants was 23.46 ± 1.71 and the mean social anxiety score was 29.55 ± 2.21. Self-esteem did not show a significant difference according to sociodemographic and clinical characteristics (p &gt; 0.05). Statistically significant differences were found in social anxiety levels in terms of educational status and occupation (p = 0.001 and p = 0.005). The relationship between seizure frequency and self-esteem had a significant negative predictive effect on social fear and restlessness in new situations (b = -0.497; p = 0.001), while the moderating effect of seizure frequency was not statistically significant (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Self-esteem of individuals with epilepsy was found to be high and homogeneously distributed independent of sociodemographic factors such as gender, age, and educational status. Social anxiety levels varied according to educational and occupational status.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"173 ","pages":"Article 110764"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}