Epilepsy & Behavior最新文献

{"title":"Obstructive sleep apnea is associated with risk for sudden unexpected death in epilepsy (SUDEP) using rSUDEP-7","authors":"Atiwat Soontornpun ,&nbsp;Christian Mouchati ,&nbsp;Noah D. Andrews ,&nbsp;James Bena ,&nbsp;Madeleine M. Grigg-Damberger ,&nbsp;Nancy Foldvary-Schaefer","doi":"10.1016/j.yebeh.2024.110121","DOIUrl":"10.1016/j.yebeh.2024.110121","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Evaluate relationships between PSG-confirmed OSA and SUDEP risk using the revised SUDEP Risk Inventory (rSUDEP-7).</div></div><div><h3>Methods</h3><div>Identified adults with epilepsy (AWE) who underwent PSG 2004–2016 at Cleveland Clinic. OSA was defined as apnea-hypopnea index (AHI)- ≥-5/h sleep; moderate/severe OSA as AHI≥15. SUDEP risk was assessed using rSUDEP-7: higher rSUDEP-7 score, greater SUDEP risk. Associations between rSUDEP-7 score and OSA groups (AHI≥15 vs. &lt;15) were evaluated using Wilcoxon rank-sum tests and multivariable linear models adjusting for age, sex, BMI, and smoking status. Spearman correlations measured relationships between rSUDEP-7 score with AHI and oxygen desaturation indices (ODI).</div></div><div><h3>Results</h3><div>OSA was present in 134 (62.6 %) of 214 AWE; moderate/severe in 75 (35 %). AWE with AHI≥15 were more likely to be male and older, had higher BMI, greater frequency of tonic-clonic seizures (TCS), longer epilepsy duration, and more likely to have drug-resistant epilepsy (DRE) and sleep-related seizures (all p&lt; 0.05). The median rSUDEP-7 score was 1 (0,3) but 37.4 % had a score ≥3 (high SUDEP risk), and 11.7 % ≥5 (highest SUDEP risk). rSUDEP-7 scores were higher in those with AHI≥15 (3 vs. 1, p = 0.001). Higher AHI and ODI 3% positively correlated with rSUDEP-7 (p=0.002 and p=0.016) while SpO₂ nadir negatively correlated with rSUDEP-7 (p=0.007). After adjustments, AWE with AHI≥15 had mean rSUDEP-7 score 1.14 points (95% CI 0.55–1.72, p&lt;0.001) higher than those with AHI&lt;15.</div></div><div><h3>Discussion</h3><div>AWE with PSG-confirmed moderate/severe OSA especially those who are older and have GTC had higher rSUDEP-7 scores potentially increasing their risk for SUDEP. Our findings support routine screening for OSA in AWE. Further studies confirming the significance and impact of OSA on SUDEP risk are needed.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between abnormal cardiac conditions and epilepsy: A two-sample Mendelian randomization study","authors":"Renfu Liu ,&nbsp;Yu Tian ,&nbsp;Xiangtao Zhang ,&nbsp;Xiaodan Zhang ,&nbsp;Yuanxiang Lin","doi":"10.1016/j.yebeh.2024.110111","DOIUrl":"10.1016/j.yebeh.2024.110111","url":null,"abstract":"<div><h3>Background</h3><div>Observational studies have consistently indicated a significant correlation between abnormal cardiac conditions and epilepsy. However, the association and direction of this relationship remain a subject of debate. This study employs a two-sample bidirectional Mendelian randomization (MR) approach to investigate the association between abnormal cardiac conditions and epilepsy.</div></div><div><h3>Methods</h3><div>Instrumental variables, represented by single nucleotide polymorphisms (SNPs) associated with epilepsy and various abnormal cardiac conditions, were derived from large-scale genome-wide association studies databases, including FinnGen and UK Biobank. Bidirectional MR analysis was conducted to estimate the association between epilepsy and abnormal cardiac conditions. Sensitivity analyses were performed using MR-Egger, weighted median, Inverse Variance Weighted, and MR pleiotropy residual sum and outlier methods.</div></div><div><h3>Results</h3><div>The forward MR analysis suggested a potential positive effect of atrial fibrillation and flutter (AF) and valvular heart diseases (VHD) on the risk of epilepsy. Conversely, the reverse MR analysis indicated that epilepsy might increase the susceptibility to AF, VHD, and heart failure.</div></div><div><h3>Conclusion</h3><div>The findings support a bidirectional relationship between AF, VHD, and epilepsy, indicating that AF and VHD can elevate the risk of developing epilepsy, while epilepsy, in turn, can also increase the risk of developing AF and VHD. Furthermore, the study suggest that epilepsy may contribute to the development of heart failure. These results underscore the importance of screening for cardiac abnormalities in patients with epilepsy and vice versa, to better understand their clinical significance and potential as modifiable risk factors.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is lateralization concordance between preoperative video-EEG, ictal SPECT, and MRI to be associated with positive psychiatric outcomes after cortico-amygdalohippocampectomy in patients with pharmacoresistant temporal lobe epilepsy associated to mesial temporal sclerosis? A retrospective cohort study","authors":"Bruna de Faria Dutra Andrade Karam,&nbsp;Michael Peres de Medeiros,&nbsp;Lucia Helena Neves Marques,&nbsp;Gerardo Maria de Araújo Filho","doi":"10.1016/j.yebeh.2024.110115","DOIUrl":"10.1016/j.yebeh.2024.110115","url":null,"abstract":"<div><h3>Objective</h3><div>The occurrence of comorbid psychiatric disorders (PD) in patients with pharmacoresistant temporal lobe epilepsy (TLE) associated to mesial temporal sclerosis (MTS) can be considered as a result of the complex interaction between biological and psychosocial factors, as well as the effects of antiseizure medications (ASM). Regarding biological aspects, despite the growing amount of knowledge, there is still a scarcity of data in literature clarifying whether a more precise definition of the seizure onset zone (SOZ) could be associated with a more favorable post-surgical psychiatric outcome. In the present study, the clinical and sociodemographic pre-surgical variables, including the results of neurophysiological and neuroimaging exams, were evaluated in patients with pharmacoresistant TLE-MTS aiming to investigate possible risk factors for the presence of PD after cortico-amygdalohippocampectomy (CAH).</div></div><div><h3>Methods</h3><div>A retrospective cohort analysis of medical records from initially 106 pre-surgical patients with pharmacoresistant TLE-MTS with PD (n = 51; 48.1 %) and without PD (n = 55; 51.9 %) proceeded. Pre-surgical clinical and sociodemographic data were compared between both groups and the predictors for the presence of post-surgical PD were characterized up to one and two years after CAH.</div></div><div><h3>Results</h3><div>Seventeen patients (16 %) had lost their follow-up in the first year after surgery, and 89 (84 %) had completed the study. No clinical and sociodemographic differences were observed between both groups of patients (p &gt; 0.05), except for a history of previous psychiatric treatment (p = 0.001). Eighteen patients (35.29 %) with pre-surgical history of PD had remission of PD after CAH, while eight (14.5 %) developed de novo PD. The previous history of PD was directly associated with the development of post-surgical PD one year after CAH (p &lt; 0.0001). Previous psychiatric treatment (p &lt; 0.01), previous history of mood (p = 0.002) and anxiety (p = 0.03) disorder, as well as discordance in lateralization between MRI, SPECT, and EEG (p = 0.02), were predictors for the development of PD two years after CAH. Post-surgical psychiatric outcomes were associated to seizure outcome based on the Engel classification (p &lt; 0,0001).</div></div><div><h3>Conclusion</h3><div>The present data observed an association between lateralization concordance of results of pre-surgical investigative exams and positive postoperative psychiatric outcomes in patients with pharmacoresistant TLE-MTS. These results could suggest that a more precise definition of the SOZ could be associated with a more favorable post-surgical psychiatric outcome after CAH.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of social factors on the outcome of status epilepticus","authors":"A Neligan ,&nbsp;S Rajakulendran","doi":"10.1016/j.yebeh.2024.110097","DOIUrl":"10.1016/j.yebeh.2024.110097","url":null,"abstract":"<div><div>In this review we look at the evidence of the impact of social factors, both inherent and external on the prognosis of status epilepticus (SE). Specifically, we look at the impact of gender, ethnicity, educational level and social deprivation on the incidence and prognosis of SE. We found evidence of clear differences in SE incidence and mortality by ethnicity (at least in the United States) with the highest incidence and lowest mortality rates in black populations. One study was identified which demonstrated a clear association of low educational attainment and increased mortality in epilepsy but not specifically SE. Similarly, there was evidence of a clear association (in adults) between social deprivation and epilepsy but again not specifically SE. Finally, there was weak evidence that social deprivation/lower economic status may be associated with higher SE mortality but this may be explained by other factors. This paper was presented at the 9th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures held in April 2024.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of reproductive risk among women with epilepsy of childbearing age","authors":"Chloé E. Hill ,&nbsp;Chun Chieh Lin ,&nbsp;Shriya Suresh ,&nbsp;Stephanie Shatzman ,&nbsp;Nishad Shaheid ,&nbsp;Sung Hyun Seo ,&nbsp;Linda M. Selwa ,&nbsp;Temenuzhka Mihaylova","doi":"10.1016/j.yebeh.2024.110107","DOIUrl":"10.1016/j.yebeh.2024.110107","url":null,"abstract":"<div><h3>Background</h3><div>Having children or planning to have children may raise many questions for women with epilepsy. Seizures and antiseizure medications (ASMs) impact contraception, fetal/early childhood development, and maternal health. Little is known regarding patients’ perspectives about reproductive risk and how those perspectives influence reproductive decision-making.</div></div><div><h3>Methods</h3><div>As a quality improvement initiative, we distributed an electronic survey within our health system to women ages 21–45 with a primary diagnosis of epilepsy/seizures. We then performed an exploratory research study to investigate perceptions of risk of epilepsy and ASMs on reproductive health and decision making. Additionally, we looked at clinical characteristics as possible predictors of fear impacting reproductive decisions.</div></div><div><h3>Results</h3><div>There were 267 responses (32% responder rate); after exclusion criteria, 233 respondents were included in the study. There were mixed responses about how fear of ASM teratogenicity impacted decisions about having children (33% very much, 34% a little, 33% not at all). While 45% responded that fear of having a child with epilepsy/seizures did not at all affect decisions about having children, for 24% this very much affected their decision. In total 42% of respondents reported they had had children. When we evaluated the impact of certain clinical characteristics, we found ASM number and valproic acid use impacted reproductive decision making, while other expected characteristics (e.g., drug-refractoriness and convulsive seizures) did not.</div></div><div><h3>Discussion</h3><div>We found variation in perceptions of risk. Overall, our data support the very personalized nature of preferences and the need for individualized counseling when guiding patients in reproductive decision making.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of physical injuries among patients with epilepsy in Sub-Sharan Africa: A systematic review and meta-analysis","authors":"Gebremeskel Kibret Abebe ,&nbsp;Biruk Beltew Abate ,&nbsp;Alemu Birara Zemariam ,&nbsp;Molla Azmeraw ,&nbsp;Habtamu Setegne Ngusie ,&nbsp;Melesse Abiye Munie ,&nbsp;Amsalu Baylie Taye ,&nbsp;Bogale Molla ,&nbsp;Befkad Derese Tilahun ,&nbsp;Addis Wondmagegn Almaw","doi":"10.1016/j.yebeh.2024.110099","DOIUrl":"10.1016/j.yebeh.2024.110099","url":null,"abstract":"<div><h3>Background</h3><div>Globally, 50 million people suffer from epilepsy, with more than 80% of patients with epilepsy living in low‐ and middle‐income countries. The World Health Organization (WHO) estimates that approximately 25 million people in Africa have epilepsy. In Sub-Saharan Africa, 50 % of patients with epilepsy experience seizure-related physical injuries, including burns, fractures, motor vehicle accidents, dental injury, soft-tissue injuries, and submersion accidents.</div></div><div><h3>Objective</h3><div>This systematic review and meta-analysis was conducted to assess the prevalence and associated factors of physical injuries among patients with epilepsy in Sub-Sharan Africa.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted between January 2012 and December 2023. An experienced librarian performed a thorough search across several databases, including PubMed, Medline, the Cochrane Database of Systematic Reviews, Up To Date, EMBASE, and NICE (National Institute for Health and Care Excellence). The search also included grey literature and unpublished studies. Data were extracted on the prevalence of physical injuries and associated factors among patients with epilepsy in Sub-Saharan Africa. A pooled analysis of prevalence was conducted using a random-effects model, and a systematic review of risk factors for physical injuries was performed.</div></div><div><h3>Results</h3><div>A total of seven studies (n = 1724) were included. The pooled prevalence physical of injuries among patients with epilepsy in Sub-Sharan Africa is found to be 63.68 % (95 % CI: 62.15, 65.22; I2 = 99.7 %; p &lt; 0.0001). Subgroup analyses were conducted by grouping the studies by country. We also employed a leave-one-out sensitivity analysis to identify potential sources of heterogeneity. Publication bias was assessed by visual inspection of meta-funnel plot and egger, begs test, and revealed there was no publication bias.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis can be used for policy maker, stakeholders and concerned body to set strategies to prevent seizure-related physical injuries among patients with epilepsy. The finding also allows clinicians to provide appropriate patient care.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-of-illness review of status epilepticus in Europe","authors":"Adam Strzelczyk ,&nbsp;Andreas Brunklaus ,&nbsp;Felix Rosenow ,&nbsp;Justyna Paprocka ,&nbsp;Susanne Schubert-Bast ,&nbsp;Leena Kämppi","doi":"10.1016/j.yebeh.2024.110105","DOIUrl":"10.1016/j.yebeh.2024.110105","url":null,"abstract":"<div><div>The objective of this review is to give an overview of published cost of illness (COI) studies on status epilepticus (SE). This review analysed studies from 2014 onwards, focusing on direct and indirect costs of SE treatment in Europe. Searches were conducted across major databases, and studies employing various methodologies were included and systematically assessed.</div><div>Six European studies from France, Germany, and Spain provided data on COI of SE treatment. Median hospital costs ranged from € 2,330 to € 6,517, and mean costs from € 5,711 to € 14,946 per admission. The median length of stay was between 5 and 14 days, with mean stays ranging from 9.2 to 21.2 days, resulting in mean daily treatment costs that ranged from € 545 to € 802. Notably, annual costs in France were estimated at € 122 million, and in Germany over € 200 million. Reported cost drivers across the studies included several factors such as very young and old age, acute-symptomatic aetiology, comorbidities, refractory or super-refractory SE, and three or more treatment steps including ventilation. Two studies also examined long-term healthcare utilisation, revealing significant ongoing resource needs.</div><div>Although recent research has improved the understanding of SE costs, data on indirect costs and long-term outcomes remain sparse. Variations in cost estimates across countries highlight the need for further studies to better understand the economic burden. Future research is needed to better assess long-term COI, quality of life, mortality and SE complications, and provide a foundation for cost-effectiveness evaluations of new treatments and interventions for SE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of magnetoencephalographic and clinical features to identify atypical self-limited epilepsy with centrotemporal spikes","authors":"Yihan Li ,&nbsp;Yingfan Wang ,&nbsp;Fengyuan Xu ,&nbsp;Teng Jiang ,&nbsp;Xiaoshan Wang","doi":"10.1016/j.yebeh.2024.110095","DOIUrl":"10.1016/j.yebeh.2024.110095","url":null,"abstract":"<div><h3>Introduction</h3><div>Our aim was to use magnetoencephalography (MEG) and clinical features to early identify self-limited epilepsy with centrotemporal spikes (SeLECTS) patients who evolve into atypical SeLECTS (AS).</div></div><div><h3>Methods</h3><div>The baseline clinical and MEG data of 28 AS and 33 typical SeLECTS (TS) patients were collected. Based on the triple-network model, MEG analysis included power spectral density representing spectral power and corrected amplitude envelope correlation representing functional connectivity (FC). Based on the clinical and MEG features of AS patients, the linear support vector machine (SVM) classifier was used to construct the prediction model.</div></div><div><h3>Results</h3><div>The spectral power transferred from the alpha band to the delta band in the bilateral posterior cingulate cortex, and the inactivation of the beta band in both the right anterior cingulate cortex and left middle frontal gyrus were distinctive features of the AS group. The FC network in the AS group was characterized by attenuated intrinsic FC within the salience network in the alpha band, as well as attenuated FC interactions between the salience network and both the default mode network and central executive network in the beta band. The prediction model that integrated MEG and clinical features had a high prediction efficiency, with an accuracy of 0.80 and an AUC of 0.84.</div></div><div><h3>Conclusion</h3><div>The triple-network model of early AS patients has band-dependent MEG alterations. These MEG features combined with clinical features can efficiently predict AS at an early stage.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"9th London – Innsbruck colloquium on status epilepticus and acute seizures, held in London in April 2024","authors":"Simon Shorvon ,&nbsp;Matthew Walker ,&nbsp;Eugen Trinka","doi":"10.1016/j.yebeh.2024.110087","DOIUrl":"10.1016/j.yebeh.2024.110087","url":null,"abstract":"<div><div>This editorial introduces the Epilepsy &amp; Behavior issue devoted to the 9th London-Innsbruck Colloquium on Status Epilepticus. It summarises the topics of the colloquium and other aspects. The selection of the presentations made in the special issue give a flavour of recent progress and development in the field.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life, depression, anxiety, and sleep in mothers and fathers of children with dravet syndrome in Sweden","authors":"Colin Reilly ,&nbsp;Björn Bjurulf ,&nbsp;Tove Hallböök","doi":"10.1016/j.yebeh.2024.110102","DOIUrl":"10.1016/j.yebeh.2024.110102","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate health-related<!--> <span><span>quality of life</span><svg><path></path></svg></span> <!-->(HRQoL), depression, anxiety and sleep in caregivers (mothers and fathers) of children with Dravet Syndrome (DS).</div></div><div><h3>Methods</h3><div>Mothers (n = 41) and fathers (n = 39) of 42 children with DS completed the Rand 36-Item Short Form Health Survey <em>(</em>SF<em>-</em>36<em>),</em> the <span><span>Hospital Anxiety and Depression Scale</span><svg><path></path></svg></span> <!-->(HADS), and the Insomnia Severity Index (ISI). Mothers’ and fathers’ SF-36 scores were compared with Swedish population values for males and females using t-tests. Differences in proportions of mothers vs. fathers classified as ‘noncases’ or ‘possible/probable’ cases of anxiety (HADS-A) and depression (HADS-D), respectively, were assessed with the chi-square test. Parents’ SF-36, HADS symptom and ISI scores were compared using t-tests. Linear regression analysis was employed to explore factors associated with sleep and mental health.</div></div><div><h3>Results</h3><div>Mothers had significantly lower scores compared with population norms on seven of eight SF-36 domains whilst fathers had lower scores on five domains. Mothers had significantly lower scores than fathers on one (i.e. Role limitation − emotional) SF-36 domain. A larger proportion of mothers than fathers had ‘possible/probable’ anxiety (83 % vs 59 %; p = 0.018), but not depression (46 % vs. 46 %; p = 0.987). Mothers reported more symptoms of anxiety than fathers (p = 0.007) but there was no difference in depression (p = 0.399). Mothers (78 %) reported more sleep difficulties than fathers (67 %) but the difference was not significant (p = 0.254). Sleep difficulties were predicted by mental health difficulties and vice versa, in mothers and fathers (all p &lt; 0.001). Increased child sleep difficulties were associated with increased maternal sleep difficulties (p = 0.003) but not paternal sleep difficulties.</div></div><div><h3>Conclusion</h3><div>Parents of children with DS have high levels of mental health and sleep difficulties and reduced HRQoL. Mothers experienced higher levels of anxiety, but not depression, than fathers. There is a need to screen parents of children for these difficulties and develop interventions to ameliorate the difficulties.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}