Epilepsy & Behavior最新文献

{"title":"SCN1A rs3812718 polymorphism modulates structural and functional brain networks in TLE: A multimodal imaging-genomics study","authors":"Yiren Chen ,&nbsp;Liyuan Fu ,&nbsp;Xiaoyang Wang ,&nbsp;Pengfan Yang ,&nbsp;Hui Xiao ,&nbsp;Shangwen Xu ,&nbsp;Hui Li","doi":"10.1016/j.yebeh.2025.110725","DOIUrl":"10.1016/j.yebeh.2025.110725","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the impact of the SCN1A rs3812718 polymorphism on gray matter volume (GMV) and resting-state functional network topology in temporal lobe epilepsy (TLE) patients.</div></div><div><h3>Methods</h3><div>60 TLE patients and 28 healthy controls (HCs) underwent genotyping and MRI (3D-T1, rs-fMRI). Participants were grouped by genotype (AA/AGvs.GG) and disease status (TLEvs.HC). Voxel-based morphometry assessed GMV; graph theory analyzed functional network topology. 2x2 ANCOVA tested genotype and disease main effects and their interaction.</div></div><div><h3>Results</h3><div>AA/AG genotype frequency was higher in (TLE vs.HCs). GMV: Significant genotype main effect (AA/AGvs.GG): reduced GMV in right temporal regions/hippocampus/left SMG; increased in left MTG/right precuneus. Significant disease main effect (TLEvs.HC): widespread GMV reductions, especially in mesiotemporal/neocortical areas. Significant genotype-by-disease interaction: TLE patients with AA/AG genotype showed the most extensive GMV reductions (bilateral ITG, fusiform gyri, right hippocampus/precuneus/occipital, left caudate/rectus).</div></div><div><h3>Functional Networks</h3><div>Significant disease main effect: reduced degree centrality in left dorsolateral prefrontal cortex (SFGdor/MFG) in TLEvs.HC. No significant interaction effects on global/nodal topology.</div></div><div><h3>Correlations</h3><div>In AA/AG TLE patients, left MTG GMV negatively correlated with epilepsy duration.</div></div><div><h3>Conclusion</h3><div>The SCN1A rs3812718AA/AG genotype is a TLE risk factor. It independently and interactively (with disease status) is associated with structural brain alterations (GMV) in TLE and is linked to disease-related functional network changes (DC) in cognitive regions. These genetic-neuroimaging signatures offer potential biomarkers for TLE precision medicine.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110725"},"PeriodicalIF":2.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of perceived social support and resilience between mental problems and stigmatization in adolescents with epilepsy: A cross-sectional study","authors":"Mehmet Emin Düken ,&nbsp;Mustafa Belli","doi":"10.1016/j.yebeh.2025.110731","DOIUrl":"10.1016/j.yebeh.2025.110731","url":null,"abstract":"<div><h3>Aim</h3><div>The present study was conducted to examine the mediating roles of perceived social support and resilience in the relationship between mental health and stigmatization in adolescents with epilepsy.</div></div><div><h3>Method</h3><div>This cross-sectional and descriptive study planned in accordance with STROBE guidelines was conducted in two hospitals in Şanlıurfa between 01.05.2024 and 31.01.2025. The study included 249 adolescents with epilepsy who met the inclusion criteria. Data were collected by using the Brief Symptom Inventory (BSI), Epilepsy Stigma Scale (ESS), Multidimensional Perceived Social Support Scale (MSPSS) and Child and Adolescent Psychological Resilience Scale (CEASRS). Analyses were conducted by using regression analysis and mediation models. Ethics committee approval was obtained and informed consent was obtained from the participants.</div></div><div><h3>Results</h3><div>It was found that 44 % of the adolescents with epilepsy who participated in the study experienced high levels of stigmatization. While a strong positive correlation was found between mental health and stigmatization (r = 0.990, p &lt; 0.001), significant negative correlations were found between perceived social support (r = -0.958, p &lt; 0.001) and resilience (r = -0.945, p &lt; 0.001) and stigmatization. According to the mediation analysis results, perceived social support (β = 0.074, CI [0.040–0.122]) and resilience (β = 0.438, CI [0.292–0.569]) significantly reduced the effect of mental health on stigmatization in adolescents with epilepsy.</div></div><div><h3>Conclusion</h3><div>The results of the study show that social support systems should be strengthened and resilience should be increased to reduce the effects of mental health and stigmatization in adolescents with epilepsy. In this respect, it is recommended to strengthen social support mechanisms and include interventions that increase resilience in clinical approaches to individuals with epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110731"},"PeriodicalIF":2.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended psychosocial follow-up after epilepsy surgery: 1–2-year results from a prospective cohort","authors":"Özge Selçukoğlu Kilimci ,&nbsp;Şenol Turan ,&nbsp;Cihan İşler ,&nbsp;Beril Kara Esen ,&nbsp;Gülçin Baş ,&nbsp;Çiğdem Özkara","doi":"10.1016/j.yebeh.2025.110712","DOIUrl":"10.1016/j.yebeh.2025.110712","url":null,"abstract":"<div><h3>Objective</h3><div>Epilepsy surgery is an effective treatment for patients with drug-resistant epilepsy, often resulting in complete seizure control. Various factors, including coping styles, clinical features, and sociodemographic variables, influence psychosocial outcomes following surgery. This study aimed to examine changes in comprehensive psychosocial outcomes following epilepsy surgery and to assess how presurgical variables influenced these results.</div></div><div><h3>Methods</h3><div>This study serves as a follow-up to our previous research, in which we evaluated patients preoperatively and 6 months postoperatively using the Social Adaptation Self-Evaluation Scale (SASS), Epilepsy Self-Efficacy Scale (ESES), Felt Stigma Scale (FSS), Rosenberg Self-Esteem Scale (RSES), and the Coping Orientation to Problems Experienced (COPE) Inventory. Twenty-seven participants who were reachable 1–2 years after surgery were re-assessed using the SASS, ESES, RSES, and FSS. Changes in scale scores over time were evaluated using the Friedman test, and correlations were examined with Spearman’s analysis.</div></div><div><h3>Results</h3><div>Patients demonstrated increased self-efficacy levels following surgery (p = 0.008). Social adaptation levels after surgery were positively correlated with the presurgical active coping, use of emotional social support, and emotional-focused coping (p = 0.006, p = 0.038, p = 0.037, respectively). Postsurgical stigma was negatively correlated with presurgical emotional-focused coping (p = 0.023). The presurgical seizure frequency was negatively correlated with the postsurgical ESES and SASS (p = 0.002, p = 0.020, respectively). Furthermore, individuals who were employed before surgery demonstrated better social adaptation following the procedure (p = 0.007).</div></div><div><h3>Conclusions</h3><div>The psychosocial outcomes following epilepsy surgery are influenced by factors beyond seizure control. A better understanding of additional factors can elucidate the variability in psychosocial outcomes and empower healthcare providers to engage in more thorough and realistic dialogue about expected outcomes following surgery. Our results highlight key factors to predict psychosocial outcomes before surgery and provide valuable insights from a one-year follow-up. These findings support the need for comprehensive presurgical evaluations to identify psychosocial challenges and improve long-term outcomes for epilepsy surgery patients.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110712"},"PeriodicalIF":2.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unknown etiology group of late onset epilepsy more likely to show epileptiform EEG abnormalities than cerebrovascular disease group","authors":"Akihiko Nakaya ,&nbsp;Kazuhiro Kato ,&nbsp;Kazutaka Jin ,&nbsp;Satoru Ohtomo ,&nbsp;Nobukazu Nakasato ,&nbsp;Masashi Aoki","doi":"10.1016/j.yebeh.2025.110721","DOIUrl":"10.1016/j.yebeh.2025.110721","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether the cerebrovascular disease (CVD) group of late-onset epilepsy shows lower detection rates of interictal and ictal epileptiform abnormalities (EAs) using routine EEG than other etiology groups.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed consecutive patients who had first seizure at age 65 years or older. The detection of EAs was investigated as well as background factors including age at EEG, timing of EEG after the last seizure, recording time of EEG, EEG-vigilance, and antiseizure medications. Multivariable logistic regression analysis was used to compare the detection rate of EAs between etiologies.</div></div><div><h3>Results</h3><div>EAs were detected in 53 (27 %) of 196 patients with late-onset epilepsy: 17 (20.7 %) of 82 patients with CVD, 9 (29.0 %) of 31 with traumatic brain injury, 4 (23.5 %) of 17 with other structural etiologies, 1 (20.0 %) of 5 with metabolic etiology, 9 (28.1 %) of 32 with dementia, and 13 (44.8 %) of 29 with unknown etiology. The odds ratios for EA detection, using the CVD group as the reference, were 1.60 for traumatic brain injury, 1.32 for other structural etiologies, 0.98 for metabolic etiology, 1.57 for dementia, and 4.10 for unknown etiology. The unknown etiology group showed significantly higher detection rate than the CVD group (<em>p</em> = 0.010).</div></div><div><h3>Conclusion</h3><div>The higher detection rate in the unknown etiology group may indicate the presence of latent etiologies with high epileptic activity, while the lower detection rate in the CVD group may reflect electrophysiologically inactive lesions.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110721"},"PeriodicalIF":2.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric disorders associated with newer antiseizure medications: A real-world disproportionality analysis of FDA adverse event reporting system","authors":"Jiahao Li ,&nbsp;Rujia Zhong ,&nbsp;Feng Zhang ,&nbsp;Yi Guo","doi":"10.1016/j.yebeh.2025.110722","DOIUrl":"10.1016/j.yebeh.2025.110722","url":null,"abstract":"<div><h3>Background</h3><div>Antiseizure medications (ASMs), particularly newer agents such as levetiracetam, topiramate, and perampanel, are fundamental in treating epilepsy and related disorders. Our study aims to analyze the psychiatric safety profiles of newer ASMs.</div></div><div><h3>Research design and methods</h3><div>The data were extracted from the US FDA Adverse Event Reporting System (FAERS) database from 2004Q1 to 2024Q2. The analysis focused on the clinical characteristics, the ranking of adverse reactions, the time-to-onset, and the severity proportion of newer ASMs-related psychiatric disorders.</div></div><div><h3>Results</h3><div>Disproportionality analysis highlighted a significant association between newer ASMs and psychiatric adverse events (AEs), with drugs like perampanel and levetiracetam showing notably high risks for severe psychiatric outcomes such as aggression, suicidal ideation, and psychosis. The median time-to-onset of psychiatric AEs was 33 days, with a substantial proportion (46.4 %) occurring within the first 30 days of treatment. Among all ASMs, perampanel has the highest severe proportion of ASM-associated psychiatric disorders at 51.5 %.</div></div><div><h3>Conclusions</h3><div>Our findings underscore a significant link between the use of newer ASMs and the risk of developing psychiatric disorders, suggesting the need for careful psychiatric assessment and monitoring when prescribing these medications.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110722"},"PeriodicalIF":2.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Adaptive mental health screening in veterans admitted to an epilepsy monitoring unit\". [Epilepsy Behav. 171 (2025) 110628].","authors":"David Engel, Corey Meyer, Sarah Senderling, Esther Fiore, Lina Lee, Jeremiah Lum, Andrea Hildebrand, Marissa Kellogg, Megan Callahan","doi":"10.1016/j.yebeh.2025.110699","DOIUrl":"https://doi.org/10.1016/j.yebeh.2025.110699","url":null,"abstract":"","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":" ","pages":"110699"},"PeriodicalIF":2.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging evidence of structural and network disruptions in adolescents with conversion disorder with seizures","authors":"Kalpana Dhanik ,&nbsp;Amit Arya ,&nbsp;Vivek Agarwal ,&nbsp;Uttam Kumar","doi":"10.1016/j.yebeh.2025.110709","DOIUrl":"10.1016/j.yebeh.2025.110709","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated structural and network-level brain alterations in adolescents with conversion disorder with attacks of seizures (CD/FS), focusing on stage-specific differences across acute and persistent presentations.</div></div><div><h3>Methods</h3><div>Sixty adolescents with CD/FS (26 acute-stage, 34 persistent-stage) and 60 age-matched controls underwent 3 T MRI. Voxel-based morphometry (VBM), source-based morphometry (SBM), and connectogram analyses were used to assess grey and white matter (GM and WM) alterations. Correlations with dissociative symptoms (DES scores) and age were evaluated.</div></div><div><h3>Results</h3><div>Compared to controls, adolescents with CD/FS showed significant reductions in total GM and WM volumes. Acute-stage CD/FS was marked by localized GM increases in the mid-temporal poles and focal WM disruptions, while persistent-stage CD/FS exhibited widespread structural abnormalities, including volume reductions in the precuneus, posterior cingulate cortex, cerebellum, and cingulum. SBM revealed GM alterations in the hippocampus, lingual gyrus, putamen, and pallidum, along with WM changes in the midbrain and precuneus. Connectogram analysis showed progressive network disintegration—acute-stage CD/FS demonstrated localized disruptions in salience (SN) and default mode networks (DMN), whereas persistent-stage CD/FS showed widespread negative connectivity across SN, DMN, limbic, and executive networks.</div></div><div><h3>Conclusions</h3><div>Findings indicate that CD/FS in adolescents progresses from localized to widespread structural and network dysfunction. These findings highlight the importance of early identification of stage-specific brain network alterations in adolescents with functional seizures, which may support future efforts to develop prognostic markers and inform individualized clinical approaches.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110709"},"PeriodicalIF":2.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of public attitudes toward people with epilepsy in Austria, Switzerland and Germany based on web-based surveys","authors":"Margarete Pfäfflin ,&nbsp;Rupprecht Thorbecke ,&nbsp;Christoph Baumgartner ,&nbsp;Stephan Rüegg ,&nbsp;Theodor W. May","doi":"10.1016/j.yebeh.2025.110719","DOIUrl":"10.1016/j.yebeh.2025.110719","url":null,"abstract":"<div><h3>Objective</h3><div>Assessment and comparison of public attitudes toward people with epilepsy (PWE) in Austria (AT), Switzerland (CH) and Germany (DE), including the identification of predictors.</div></div><div><h3>Methods</h3><div>Web-based surveys were conducted in all three countries using the same method of data collection, data weighting and validated questionnaires: SAPE (Scale of Attitudes toward People with Epilepsy) to assess <em>Social Distance, Stereotypes, Personal Concerns, and Emotional Reactions,</em> and <em>Suitability of Professional</em> and <em>Leisure Activities for PWE, Epilepsy Knowledge, Experience with epilepsy,</em> and <em>Sociodemographic data</em> of the respondents. For comparison with former surveys the <em>Caveness Questions</em> (CQ) were added. Adult respondents (≥ 18 years) who had heard of epilepsy from AT (n = 1017), CH (n = 951), and DE (n = 1001) were included.</div></div><div><h3>Results</h3><div>About two thirds of the population have known someone with epilepsy, around half have witnessed a seizure but less than half would know what to do during a seizure. Attitudes toward PWE were similar across the three countries and did not differ significantly (presented as mean ± standard deviation in the total group): <em>Concerns</em> (41.9 ± 23.2) and <em>Fears</em> (36.6 ± 23.9) in dealing with PWE being more pronounced than <em>Anger</em> (9.6 ± 17.1), negative <em>Stereotypes</em> (17.7 ± 18.3), and <em>Social Distance</em> (17.0 ± 18.6). One’s own involvement appears to be a key in reducing social distance and improving attitudes toward PWE: Personal contact with PWE, the ability to help during a seizure, and knowledge about treatment of epilepsy were the most important predictors for positive attitudes. Women reported less <em>Social Distance</em> and <em>Anger</em> than men. Only 5–7 % of the respondents considered epilepsy as insanity, but between 22–27 % would agree with at least one distancing item of the CQ. <em>Professional activities</em> involving dangerous situations or weapons and those involving direct responsibility for a helpless person (baby) were considered less suitable for PWE by around 40 % or more of the respondents in all three countries. However, the share of those who were uncertain about the <em>Suitability of Occupational</em> and <em>Leisure Activities</em> was quite high.</div></div><div><h3>Significance</h3><div>For the first time a common survey was conducted in the three German speaking countries of Austria, Switzerland and Germany with the new tool (SAPE) encompassing adapted scales on <em>Social Distance</em> and <em>Emotional Reactions</em>. The survey laid the foundation for monitoring changes in attitudes in the three countries in the long term and shows which priorities should be set for desirable joint actions by the three Epilepsy Leagues/Societies to positively influence the attitudes of the populations toward PWE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110719"},"PeriodicalIF":2.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health disparities in youth with Epilepsy: A closer look at behavioral health outcomes","authors":"Janelle L Wagner ,&nbsp;Sonal Bhatia ,&nbsp;Christopher W Beatty ,&nbsp;Senyene E. Hunter ,&nbsp;Imelda Vetter ,&nbsp;Grace Gaston ,&nbsp;Cortney Wolfe-Christensen","doi":"10.1016/j.yebeh.2025.110716","DOIUrl":"10.1016/j.yebeh.2025.110716","url":null,"abstract":"<div><div>A recent scoping review of health disparities and equities in pediatric epilepsy identified behavioral health outcomes as the largest represented domain, comprising 23% of findings. The current study sought to elucidate these findings by examining social determinants of health (SDOH), including: race/ethnicity, insurance, socio-economic status (SES), and education, within the context of four behavioral health domains: mental health, neurocognitive, family functioning, and health-related quality of life (HRQOL). Results from the scoping review revealed a total of 76 unique behavioral health findings, with more health disparities than equities in the neurocognitive and HRQOL domains and more health equities than disparities in the mental health and family functioning domains. The highest number of disparities was related to socio-economic status (SES; 74.1%). However, due to the complexity and intersectionality of SDOH in behavioral health functioning, combined with differences in methodologies between studies, we caution against general conclusions regarding the role of SDOH in barriers to pediatric epilepsy care. Instead, specific SDOH should be considered within each behavioral health domain.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110716"},"PeriodicalIF":2.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy and migraine: A bidirectional mendelian randomization study","authors":"Fangliang Chen ,&nbsp;Jianyun Sun ,&nbsp;Jianxiang Lei ,&nbsp;Yu Wang","doi":"10.1016/j.yebeh.2025.110723","DOIUrl":"10.1016/j.yebeh.2025.110723","url":null,"abstract":"<div><h3>Objective</h3><div>Numerous observational research reports have consistently demonstrated a significant association between migraines and epilepsy, but it remains uncertain whether a causal relationship exists between these two diseases. This study aims to explore the potential causal relationship between epilepsy and migraine through a two-sample bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>A two-sample bidirectional MR analysis was conducted using the data from the genome-wide association studies (GWAS) of epilepsy and migraine in the European population. The primary analytical approach was the inverse variance weighted (IVW) method, with additional MR methods, including MR-Egger and weighted median, employed for complementary analysis. Comprehensive sensitivity analyses were also performed to assess the robustness of the results.</div></div><div><h3>Results</h3><div>The MR analysis showed no evidence of a causal relationship between epilepsy and migraine (P &gt; 0.05) in either the forward or reverse analysis. Sensitivity analyses validated the reliability of the results.</div></div><div><h3>Significance</h3><div>No evidence of a genetic causal relationship between migraine and epilepsy was identified. However, the mechanisms underlying the observed association between the two diseases in observational studies warrant further investigation.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"172 ","pages":"Article 110723"},"PeriodicalIF":2.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}