Epilepsy & Behavior最新文献

{"title":"Mathematics skills in children with genetic generalized epilepsy: Cognitive and clinical correlates. Preliminary results","authors":"Belinda J. Poole ,&nbsp;Natalie L. Phillips ,&nbsp;Camilla Gilmore ,&nbsp;Anna Mandalis ,&nbsp;John Lawson ,&nbsp;Richard Webster ,&nbsp;Kavitha Kothur ,&nbsp;Samantha McLean ,&nbsp;Suncica Lah","doi":"10.1016/j.yebeh.2024.110110","DOIUrl":"10.1016/j.yebeh.2024.110110","url":null,"abstract":"<div><div>Impairments in mathematics have been found in children with Genetic Generalized Epilepsy (GGE), yet little is known about the underpinnings of these difficulties. The aim of this study was to investigate basic numeracy and secondary mathematics skills in GGE and explore cognitive and clinical correlates that relate to those skills. Nineteen children with GGE and 22 typically developing controls aged 8–16 years completed a neuropsychological battery which assessed: (i) basic numeracy skills: non-symbolic and symbolic magnitude comparison; (ii) secondary mathematics skills: calculation, reasoning, and fluency; and (iii) cognitive skills: intelligence, fluid reasoning, processing speed, and working memory. Epilepsy clinical factors (age of epilepsy onset, duration of epilepsy, number of anti-seizure medications) were also recorded. Children with GGE were impaired in select basic numeracy skills (non-symbolic magnitude comparison), and all secondary mathematics skills compared to controls. In children with GGE, the visuo-spatial central executive correlated with both basic numeracy skills. The verbal central executive correlated with mathematics reasoning. Non-verbal intelligence was related to symbolic magnitude comparison and mathematics reasoning. Fluid reasoning was correlated with non-symbolic magnitude comparison and mathematics problems solving. Epilepsy variables did not relate to mathematics outcomes. Overall, we found that children with GGE experience significant difficulties in select basic numeracy and all secondary mathematics skills. Risk factors for mathematics difficulties included reduced working memory capacity, lower intelligence and fluid reasoning. Our findings suggest that children with GGE may require accommodation for limited central executive working memory capacity in combination with academic supports for poor mathematics skills.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Antiseizure Medication Adherence in Paediatric Epilepsy: Implications for Clinical Practice and Patient Care","authors":"Anchu Anna Cherian ,&nbsp;Mini Sreedharan ,&nbsp;Priya Sreenivasan ,&nbsp;Mary Iype ,&nbsp;Shahanaz Ahamed ,&nbsp;Azmi Habeeb ,&nbsp;Reshmi Raveendran ,&nbsp;Roshni R. Lal","doi":"10.1016/j.yebeh.2024.110089","DOIUrl":"10.1016/j.yebeh.2024.110089","url":null,"abstract":"<div><h3>Objective</h3><div>Non adherence to antiseizure medications (ASM) is a common and modifiable risk factor for poor control of epilepsy and contributes to increased hospitalizations, bias in assessing the effectiveness of therapy and inaccurate clinical decision making.The aim of the study was to estimate proportion of nonadherence to antiseizure medications among children with epilepsy and to identify clinical and demographic factors that contribute to antiseizure medication non adherence.</div></div><div><h3>Methods</h3><div>Consecutive subjects ≤ 18 years with epilepsy, on antiseizure medications for atleast three months, attending Pediatric Neurology OPD, Government Medical College Thiruvananthapuram, Kerala, India were included in the study. Self reported adherence to antiseizure medications was measured using Medication Adherence Report Scale questionnaire. Perceptions towards medications were assessed using Beliefs about Medicines Questionnaire Clinicodemographic factors and medication beliefs were analysed to examine their association with non-adherence in the participating children.</div></div><div><h3>Results</h3><div>The rate of non-adherence in children with epilepsy was 32%. 68% of the study population had high necessity beliefs and 60% showed low concern beliefs, which indicated overall positive perception towards medications. Univariate analysis showed that the following were significantly associated with ASM non adherence: ASM side effects (OR:3.01; 95% CI:1.52–5.92; p &lt; 0.001) and ASM Concerns (OR: 0.84; 95% CI: 0.77–0.92; p 0.0003) and Necessity-Concern Differential Score (OR: 1.19; 95% CI: 1.10–1.29; p 0.0001). Other clinic-demographic variables did not exhibit a significant association with adherence. Multivariate analysis showed that both ASM side effects and ASM beliefs, represented by NCD score remained significant.</div></div><div><h3>Conclusion</h3><div>Perceptions towards medications have an important and potentially modifiable association with medication non adherence. Interventions to improve adherence should be tailored to each patient, including measures to address the specific beliefs of the patient and the family, along with practical barriers such as side effects of medications.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case series of the efficacy and tolerability of ketogenic diet in children with drug-resistant epilepsy due to neonatal hypoglycemia","authors":"Xiangjun Dou ,&nbsp;Yan Wu ,&nbsp;Lili Liang ,&nbsp;Yane Yang ,&nbsp;Fengtong Li ,&nbsp;Xia Li ,&nbsp;Dong Wang","doi":"10.1016/j.yebeh.2024.110088","DOIUrl":"10.1016/j.yebeh.2024.110088","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to investigate the effectiveness and tolerance of the ketogenic diet (KD) in children who have drug-resistant epilepsy (DRE) caused by neonatal hypoglycemia.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of the data from pediatric patients who were diagnosed with neonatal hypoglycemia-related DRE and initiated a KD at Xi’an Children’s Hospital between May 2014 and March 2023.</div></div><div><h3>Results</h3><div>Nine patients were enrolled in this study. The mean age of seizure onset was 6.16 ± 3.97 months, with a mean age of dietary therapy initiation at 21.56 ± 10.94 months and a median diet duration of nine months (range: 3–39.6 months). All of the nine patients (seven males) had daily seizures, and the most common seizure type was epileptic spasms. Magnetic resonance imaging (MRI) of the brain in all nine patients revealed bilateral atrophy of the occipital-parietal cortex, with or without gliosis. Of the patients studied, 22.2 % were classified as definite KD responders. These individuals achieved seizure freedom after one month of starting KD treatment and maintained a seizure-free state for over 22 months. One patient (11.1 %) was a partial KD responder who had a &gt; 50 % seizure reduction within three months from KD initiation and continued the diet therapy for more than one year. None of the patients stopped taking KD because they could not tolerate the majority of the adverse effects, which were mild. At the last follow-up, six patients (66.7 %) had stopped their diet therapy with lack of efficacy being the leading cause.</div></div><div><h3>Conclusions</h3><div>KD is a safe and tolerable alternative treatment in pediatric patients with DRE secondary to neonatal hypoglycaemia. Most of the time, KD has minimal efficacy; however, diet therapy may be quite helpful for some patients. Thus, for DRE associated with neonatal hypoglycemia, KD treatment is appropriate to consider.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise training on children with Epilepsy: A systematic review based on the ICF model","authors":"Shiau-Chian Jeng ,&nbsp;Cheng-Jhih Song ,&nbsp;Kuang-Lin Lin ,&nbsp;Wen-Yu Liu","doi":"10.1016/j.yebeh.2024.110072","DOIUrl":"10.1016/j.yebeh.2024.110072","url":null,"abstract":"","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events associated with Stiripentol in children aged 0–17 years: An analysis of a real-world pharmacovigilance database","authors":"Tianyu Chen ,&nbsp;Qiying Chen ,&nbsp;Yuezhen Zhang ,&nbsp;Ting Liu","doi":"10.1016/j.yebeh.2024.110073","DOIUrl":"10.1016/j.yebeh.2024.110073","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the occurrence of adverse drug events (ADEs) associated with Stiripentol (STP) use in children aged 0–17 years in real-world clinical settings. <strong>Methods:</strong>ADE reports on STP in children aged 0–17 years were collected from the WHO Global Case Safety Pathology Reporting Database (VigiBase), the U.S. Food and Drug Administration’s Spontaneous Adverse Event Reporting System database (FAERS), and the European Medicines Agency’s Pharmacovigilance database (Eudra Vigilance). Pharmacovigilance signals were identified through Reporting Odds Ratio (ROR), and Proportional Reporting Ratio (PRR).</div></div><div><h3>Results</h3><div>In total, 31,990 ADEs were reported with “Stiripentol” as the primary suspect drug. This includes 595 ADEs from the Eudra Vigilance, 1,353 ADEs from the FAERS, and 998 ADEs from the VigiBase. All three databases indicate a higher incidence of ADEs related to STP in the categories of nervous system disorders, general disorders and administration site conditions, injury, poisoning and procedural complications, and metabolism and nutrition disorders. A higher proportion of children aged 3–11 years reported (16.48 %–32.44 %). The FAERS data shows that cerebellar atrophy (PRR of 332.94, ROR of 532.10) is the strongest signal for children aged 0–2 years, while changes in seizure presentation (PRR of 110.76, ROR of 121.06) is the strongest signal for children aged 3–11 years. For children aged 12–17 years, seizures (PRR of 46.99, ROR of 47.40) and decreased appetite(PRR of 45.51, ROR of 45.96) are the strongest signals. The Eudra Vigilance results show that boys have higher ADEs than girls for investigations, blood and lymphatic system disorders, hepatobiliary disorders, infections and infestations in children aged 0–17 years. On the other hand, girls have higher ADEs than boys for skin and subcutaneous tissue disorders, injury, poisoning and procedural complications, general disorders and administration site conditions, and gastrointestinal disorders.</div></div><div><h3>Conclusion</h3><div>In the clinical application of STP in pediatrics, it is important to examine ADEs in Nervous system disorders, Injury, poisoning and procedural complications, General disorders and administration site conditions, and Metabolism and nutrition disorders. Further studies should confirm whether there are age and gender differences in different ADEs.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the health-seeking behaviors of people with epilepsy","authors":"Nuray Bingöl ,&nbsp;Neşe İşcan Ayyildiz ,&nbsp;Dilan Aktepe Coşar","doi":"10.1016/j.yebeh.2024.110063","DOIUrl":"10.1016/j.yebeh.2024.110063","url":null,"abstract":"<div><h3>Purpose</h3><div>Health-seeking behaviors of individuals who have epilepsy might affect the treatment of the disease, recovery process, and self-care activities. The present study was conducted to determine the health-seeking behaviors of individuals who have epilepsy.</div></div><div><h3>Materials and methods</h3><div>The present study was conducted in a descriptive and cross-sectional design with 190 epilepsy patients who applied to the Neurology Clinic in the north and east of Turkey between April 2023 and January 2024. The data of the study were collected by using the Introductory Data Form, Health-Seeking Behavior Scale (HSBS). The IBM SPSS 27 software, variance analysis, Tamhane T2, ANOVA Test, Tukey Test, and Multiple Regression Analysis were used to evaluate the study data.</div></div><div><h3>Results</h3><div>The mean score of the online health-seeking behavior sub-dimension of the Health-Seeking Behavior Scale of the individuals who had epilepsy was found to be 13.32 ± 5.40, the mean score of the professional health-seeking behavior sub-dimension was 9.92 ± 2.75, and the mean score of the traditional health-seeking behavior sub-dimension was 8.46 ± 3.29. No significant differences were detected between individuals’ sex, seizure types, and health-seeking behaviors, and a significant difference was detected between marital status, educational status, place of residence, occupation, income level, seizure frequency, and medication use status and health-seeking behaviors (p &lt; 0.05). According to the multiple linear regression analysis that was used to examine the effects of sociodemographic characteristics of individuals with epilepsy on health seeking behavior scale scores, it was found that sociodemographic characteristics such as educational status, place of residence, marital status, and age significantly affected online, professional, and traditional health seeking behavior scores.</div></div><div><h3>Conclusion</h3><div>In conclusion, it was found in the present study that the online health-seeking behavior of the individuals who had epilepsy was higher than other health-seeking behaviors. The health-seeking behaviors of patients were affected by sociodemographic characteristics (e.g., marital status, educational status, place of residence, occupation, income level, seizure frequency, and medication use). It is of great importance to conduct larger future studies on individuals who have epilepsy and are seeking traditional treatment for epileptic seizures because the sources from which health information is obtained might affect the diagnosis, treatment, and recovery processes.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term effects of limbic non-convulsive status epilepticus in peri-adolescent rats","authors":"Reem El Jammal ,&nbsp;Ali Tfaily ,&nbsp;Ashlyn G. Cochran ,&nbsp;Tyler Nguyen ,&nbsp;Derryl Miller ,&nbsp;Nour El Ayoubi ,&nbsp;Talha Soluoku ,&nbsp;Fletcher A. White ,&nbsp;Makram Obeid","doi":"10.1016/j.yebeh.2024.110086","DOIUrl":"10.1016/j.yebeh.2024.110086","url":null,"abstract":"<div><div>To optimize the clinical approach to non-convulsive status epilepticus (NCSE), it is essential to gain insight into its long-term effects on cognition and behaviors. Here, we investigated limbic NCSE-induced hippocampal injury and behavioral deficits in <em>peri</em>-adolescent rats. NCSE was induced in P43 <em>Sprague Dawley</em> <!-->rats with intrahippocampal subconvulsive doses of kainic acid (NCSE group, n = 14) under continuous epidural cortical electroencephalography (EEG). Controls received volume-matched saline (n = 18). Following one month of continuous EEG monitoring, rats were sequentially subjected (P73-91) to the open field, the Morris water maze (MWM), and the modified two-way active avoidance (MAAV). Rats were sacrificed at P91 to histologically assess hippocampal injury with NeuN (neuronal nuclei) staining, levels of GFAP (glial fibrillary acidic protein), and synaptophysin (Syp). Following kainic acid administration, the NCSE group experienced electroclinical seizures characterized by behavioral arrest and oromotor automatisms without tonic-clonic activity (latency: 15.93 ± 4.70 min, duration: 68.35 ± 17.97 min). There were no seizure recurrences in the rest of the long-term recordings. Compared to controls, NCSE rats had impaired place learning in the MWM, and lower rates of context-cued shock avoidance in the MAAV (p &lt; 0.05). The NCSE and control groups had comparable hippocampal neuronal densities and GFAP levels, but NCSE rats had significantly lower hilar Syp levels. One episode of limbic NCSE during <em>peri</em>-adolescence results in later life hippocampal synaptic dysfunction and contextual learning deficits. These data suggest that the diagnosis and treatment of NCSE should be prompt.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain damage caused by status epilepticus: A prospective MRI study","authors":"P Bosque Varela ,&nbsp;L Machegger ,&nbsp;J Steinbacher ,&nbsp;A Oellerer ,&nbsp;J Pfaff ,&nbsp;M McCoy ,&nbsp;E Trinka ,&nbsp;G Kuchukhidze","doi":"10.1016/j.yebeh.2024.110081","DOIUrl":"10.1016/j.yebeh.2024.110081","url":null,"abstract":"<div><h3>Background</h3><div>Status epilepticus (SE) is a severe neurological condition that might lead to long-term consequences such as neuronal death. This study investigated whether SE leads to brain volume loss by characterizing the dynamic of <em>peri</em>-ictal MRI abnormalities (PMA) through follow-up MRIs and assessing whether SE duration and specific outcome characteristics are associated with brain atrophy.</div></div><div><h3>Methods</h3><div>A prospective single-center cohort study enrolled 590 adult patients with definitive or possible SE. MRI in an acute setting was performed in 353/590 (60 %) patients. Follow-up MRIs at one week and one month were conducted to assess the reversibility of PMA. Measurements of diffuse brain volume were performed by employing a voxel-based morphometry with FreeSurfer, comparing an initial MRI with a follow-up test done four weeks after the initial one. The study analyzed the correlation between brain volume loss, SE duration, and clinical outcomes.</div></div><div><h3>Results</h3><div>PMA were observed in 156/353 (44 %) patients in at least one MRI sequence. In 44/83 (53 %) patients, PMA were reversible in one week. PMA persisted in 39/83 (47 %) patients. A second follow-up MRI was performed four weeks after the initial MRI in 33/39 (85 %) patients. In 14/33 (42 %), the MRI showed signs of focal atrophy, mostly in hippocampus. Volumetric analysis performed in patients who underwent two follow-up MRIs, indicated that 85 % of patients (28/33) had a decreased diffuse brain volume, with a median volume reduction of 16 %. A moderate negative correlation was found between diffuse brain volume and SE duration (Spearman correlation: −0.57) as well as hospitalization length (Spearman correlation: −0.60). This indicates that longer SE duration and extended hospitalization were associated with a greater brain volume loss.</div></div><div><h3>Conclusion</h3><div>In this prospective study, a proportion of patients displayed cerebral volume loss following a SE. These patients had longer duration and worse outcome of SE. However, the findings should be interpreted with caution due to several limitations, including the lack of consideration for underlying etiologies that may contribute to volume loss.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, methods and circumstances of suicide in epilepsy: A population-based study in Sweden","authors":"Sara Melin ,&nbsp;Torbjörn Tomson ,&nbsp;Olafur Sveinsson ,&nbsp;Tomas Andersson ,&nbsp;Sofia Carlsson ,&nbsp;Christian Rück ,&nbsp;Karin Wirdefeldt","doi":"10.1016/j.yebeh.2024.110106","DOIUrl":"10.1016/j.yebeh.2024.110106","url":null,"abstract":"<div><h3>Objective</h3><div>Persons with epilepsy have a higher risk of suicide compared to the general population, but limited data makes it unclear how extensive this risk is and who is most vulnerable. Our study aimed to explore the incidence of suicide among persons with epilepsy in Sweden, and compare to the general population. To facilitate prevention, we also wanted to examine methods and circumstances of suicide.</div></div><div><h3>Methods</h3><div>We identified all individuals with a diagnosis of epilepsy (ICD G40) in the Swedish Patient Register between 1998 and 2005 who were alive in 2006 (n = 60,952). Among them, 190 cases of suicide were recorded in the National Cause of Death Register during follow-up 2006 to 2011. We reviewed their medical records, death certificates, and autopsy records to validate the cause of death and epilepsy diagnosis, as well as collect information on suicide method and circumstances. After validation we calculated the incidence rates by age and sex and standardized mortality ratios (SMRs) with 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>Overall suicide incidence was 40.0/100,000 person-years (95 % CI 33.0–47.9). Incidence was highest in age 45 to 64 years (61.3, 95 % CI 46.4–79.1) and appeared higher in men than in women with epilepsy. Compared to the general population, individuals with epilepsy had twice the risk of suicide (SMR 2.03 CI 1.67–2.45) and the excess risk appeared more pronounced in women (SMR 2.70 CI 1.92–3.68) than in men (SMR 1.80 CI 1.40–2.26). Intoxication (50 %) was the most common method, followed by hanging, cutting weapons and guns (25 % combined).</div></div><div><h3>Significance</h3><div>Our results confirm that suicide is overrepresented in individuals with epilepsy, especially in middle age. Incidence was higher in men but the SMR was higher among women, suggesting that the effect of epilepsy on suicide risk is greater for women than for men. Identifying subgroups that are particularly vulnerable is important for suicide prevention.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsy","authors":"Mateus Eduardo Herpich ,&nbsp;Leonardo de Oliveira Guarnieri ,&nbsp;Antônio Carlos Pinheiro de Oliveira ,&nbsp;Márcio Flávio Dutra Moraes","doi":"10.1016/j.yebeh.2024.110076","DOIUrl":"10.1016/j.yebeh.2024.110076","url":null,"abstract":"<div><div>This study used intra-hippocampal injections of Kainic Acid (KA) in Wistar rats to induce spontaneous recurrent seizures (SRS) after a 9-day latent period. A post-conditioning protocol with LPS, injected at the same site 72 h after the initial KA insult, was employed to trigger secondary competing processes. To evaluate the post-conditioning effect of LPS, 25 animals were divided into four groups: SAL-SAL (n = 6), KA-SAL (n = 6), SAL-LPS (n = 7), and KA-LPS (n = 6). SRS occurrence and seizure duration were quantified through video monitoring from days 9 to 17, along with other ictal behaviors, such as tail-chasing and wet-dog-shakes. Behavioral assessments revealed that the KA-LPS group had preserved sucrose preference and intact long-term memory in the object recognition test, indicating reduced depressive-like behavior and cognitive preservation compared to the KA-SAL group. The forced swim test showed increased depressive-like behavior in the SAL-LPS group, with LPS mitigating these effects in the KA group. The marble-burying test showed no significant differences among groups. Animals were euthanized on day 26, and hippocampal slices were analyzed using fluoro-jade staining for cell death and immunofluorescence staining for Iba-1 (microglia) and GFAP (astrocyte) labeling. The results support the hypothesis that epileptogenesis involves a cascade of plastic changes in neural networks and that precise, timely interventions can potentially interfere with this process.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}