Epilepsy & Behavior最新文献

{"title":"Status epilepticus induced on postnatal day 7 alters ultrasonic vocalization call types on postnatal days 8 and 9","authors":"Joaquin N. Lugo III ,&nbsp;Leighton A. Douglas ,&nbsp;John M. Reinhart ,&nbsp;Katherine J. Blandin ,&nbsp;Danielle Santana-Coelho ,&nbsp;Joaquin N. Lugo","doi":"10.1016/j.yebeh.2025.110466","DOIUrl":"10.1016/j.yebeh.2025.110466","url":null,"abstract":"<div><div>A single instance of early-life status epilepticus (SE) in neonatal mice results in cognitive and behavioral impairments. The present study investigated the effects of SE on postnatal day (PD) 7 to determine the impact on auditory communication behavior. We used kainic acid to induce SE on PD7 and recorded isolation-induced ultrasonic vocalizations (USV) on PD8 and 9. We found SE did not alter the total number, total duration, average call duration, peak frequency, or low frequency in male and female mice on PD8 or PD9. However, there were sex-specific differences in call types. Female SE mice had an increase in chevron, complex, and upward calls, and a decrease in frequency steps, short, and two-component calls compared to female saline controls on PD8. Females with SE recorded on PD9 had an increase in composite, downward, and flat calls and a decrease in chevron, complex, upward, and frequency steps compared to female saline controls, p &lt; 0.05. Male SE mice that had their USVs recorded on PD8 had an increase in chevron, frequency steps, and two-component calls, and had a decrease in downward, upward, and flat calls compared to male saline controls. In contrast, SE males that had their USVs recorded on PD9 had an increase in downward and short calls, and a decrease in chevron, composite, frequency steps, and two-component calls compared to male saline controls, p &lt; 0.05. This study contributes to a systematic examination of the influence of early-life seizures on communication in mice and the sensitivity of call types in determining deficits.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110466"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative clinical outcomes in children with Febrile Infection-Related Epilepsy Syndrome (FIRES)","authors":"Jia Hui Teo ,&nbsp;Wai Chen Lim ,&nbsp;Mae Shyan Wong ,&nbsp;Jeremy B Lin ,&nbsp;Velda X Han ,&nbsp;Zhi Min Ng ,&nbsp;Terrence Thomas","doi":"10.1016/j.yebeh.2025.110467","DOIUrl":"10.1016/j.yebeh.2025.110467","url":null,"abstract":"<div><h3>Background and aims</h3><div>We evaluated functional, emotional, and behavioural outcomes in children with FIRES in those who received only conventional treatments versus those who received biologics and/or ketogenic diet.</div></div><div><h3>Methods</h3><div>A retrospective chart review of children (&lt;18 years) diagnosed with FIRES at two paediatric hospitals. Children were analysed according to two time periods according to availability of biologics (from 2018 onwards). Functional outcomes were assessed via modified Rankin Scale (mRS) and paediatric functional independence measure (WeeFIM). Aggression symptoms (screened with modified overt aggression scale (MOAS)), diagnoses of attention deficit/ hyperactivity disorder (ADHD), and anxiety and depression were also recorded. These outcome measures were analysed in intervals, up to 24 months post diagnosis.</div></div><div><h3>Results</h3><div>There were 30 children (mean age 8.9 ± 4.2 years) diagnosed with FIRES. Median mRS at 12 months post FIRES was 2 (IQR 1–5). WeeFIM score was lower at discharge (p = 0.053) to 24 months follow up (p = 0.030) in children who required biologics and/or KD. Aggression was more prevalent (53.5 %) in the latter period (2018–2023) with median MOAS scores higher at discharge (p = 0.019) and follow up at 24 months (p = 0.10). Inattention (33.3 %) and mood disorders (20 %) were observed in similar proportions of children across both time periods. Aggression appeared earlier (median 1.8 months, IQR 1–4.5) whilst inattention and mood disorder were noted later (median 4 months, IQR 1.8–10.5 and median 27 months, IQR 12 = 39 respectively).</div></div><div><h3>Conclusion</h3><div>All children recovering from FIRES need to be screened for potential long-term emotional and behavioural sequelae.</div></div><div><h3>What this paper adds</h3><div>(1) Behavioural and emotional sequelae were observed in FIRES regardless of whether biologics and/or Ketogenic Diet treatment was given.</div><div>(2) Aggression symptoms appeared earlier, whilst inattention and mood disorder were noted later during follow up.</div><div>(3) All children post FIRES should be screened for long-term emotional and behavioural sequelae.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110467"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“The traditional healer said, ’I had a genie that scared me in my eyes, and that is why I fall“: An ethnographic study in Mahenge, Tanzania","authors":"Pendo F. Magili ,&nbsp;Isolide S. Massawe ,&nbsp;Vivian P. Mushi ,&nbsp;Dan K. Bhwana ,&nbsp;William Matuja ,&nbsp;Robert Colebunders ,&nbsp;Helen Cross ,&nbsp;Josemir W. Sander ,&nbsp;Arjune Sen ,&nbsp;Charles R. Newton ,&nbsp;Sloan Mahone ,&nbsp;Bruno P. Mmbando","doi":"10.1016/j.yebeh.2025.110463","DOIUrl":"10.1016/j.yebeh.2025.110463","url":null,"abstract":"<div><h3>Background</h3><div>In many low-income countries, individuals with epilepsy often turn to traditional healers as their first source of treatment after the onset of seizures. However, their experiences with traditional healing practices remain poorly understood. This study examines the perceptions and experiences of people with epilepsy in relation to traditional healing in Mahenge, Tanzania.</div></div><div><h3>Methods</h3><div>A culturally specific ethnographic approach, centred on oral history, was employed to capture rich, contextually grounded narratives. A total of 45 oral history interviews were conducted with individuals living with epilepsy from 21 villages in Mahenge. Participants were purposively selected based on the following criteria: being at least 18 years of age, having a diagnosis of epilepsy, and the ability to recount their experiences in Swahili, the primary language spoken in the region. Data were manually analysed using thematic analysis.</div></div><div><h3>Results</h3><div>Traditional healers often attribute epilepsy to supernatural causes, such as curses or witchcraft, linking seizure onset to past events believed to have triggered the condition. Their treatment practices are frequently accompanied by strict behavioural restrictions, which can be challenging for individuals with epilepsy to follow and are sometimes cited as reasons for treatment failure. Moreover, some participants reported experiences of physical, emotional, and even sexual harassment during their encounters with traditional healers.</div></div><div><h3>Conclusion</h3><div>There is a strong reliance on traditional healing practices for epilepsy, where cultural beliefs and rituals can hinder accurate diagnosis and effective care. Raising awareness about epilepsy, its medical management, and the rights of people with epilepsy, both among traditional healers and the broader community, is essential to improve care and protect the well-being of those affected.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110463"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxoplasma gondii seropositivity as a risk factor for epilepsy: A discordant monozygotic twin study","authors":"Yew Li Dang ,&nbsp;Kate Esnault ,&nbsp;Marcel J. Leroi ,&nbsp;Piero Perucca ,&nbsp;Samuel F. Berkovic","doi":"10.1016/j.yebeh.2025.110492","DOIUrl":"10.1016/j.yebeh.2025.110492","url":null,"abstract":"<div><h3>Objective</h3><div><em>Toxoplasma gondii (T. gondii)</em> seropositivity has been reported to have up to a five-fold increased risk for epilepsy. However, substantial heterogeneity in methodology exists across these studies. Furthermore, other studies failed to replicate an association between <em>T. gondii</em> seropositivity and epilepsy. To address these inconsistencies, we investigated this issue in monozygotic (MZ) twin pairs discordant for epilepsy, a method that controls for age, sex and genetic factors.</div></div><div><h3>Methods</h3><div>We analyzed 32 MZ twin pairs who are discordant for epilepsy, comparing rates of <em>T. gondii</em> seropositivity (IgG) between affected and unaffected twins. The odds ratio for <em>T. gondii</em> seropositivity in affected twins compared to their unaffected co-twins was calculated using McNemar’s chi-squared paired proportion test. Factors associated with <em>T. gondii</em> seropositivity were assessed using Fisher’s exact test and Welch’s <em>t</em>-test, as appropriate.</div></div><div><h3>Results</h3><div>The frequency of seropositivity in affected twins compared to their unaffected co-twins did not differ (odds ratio of 1.67 [95 % CI: 0.39–6.97], <em>p</em> = 0.72), indicating no significant association between <em>T. gondii</em> seropositivity and epilepsy in this cohort. Age at testing was associated with <em>T. gondii</em> seropositivity, with individuals found to be seropositive being older than those who were seronegative [mean age at testing (SD) 59.1 years (12.6) vs 47.7 years (14.3), <em>p</em> = 0.03].</div></div><div><h3>Conclusion</h3><div>In our cohort of MZ twins discordant for epilepsy, we found no evidence for an association between <em>T. gondii</em> seropositivity and epilepsy. Larger carefully controlled studies are warranted.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110492"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision support system based on ensemble models in distinguishing epilepsy types","authors":"Pınar Bengi Boz ,&nbsp;Cevher Özden","doi":"10.1016/j.yebeh.2025.110470","DOIUrl":"10.1016/j.yebeh.2025.110470","url":null,"abstract":"<div><div>This study aimed to classify patients’ focal (frontal, temporal, parietal, occipital), multifocal, and generalized epileptiform activities based on EEG findings using artificial intelligence models. The study included 575 patients followed in the Neurology Epilepsy Polyclinics of Adana City Training and Research Hospital between June 2021 and July 2024. Patient history, examination findings, seizure characteristics and EEG results were retrospectively reviewed to create a comprehensive database. Initially, machine learning architectures were applied to differentiate generalized and focal epilepsy. Subsequently, EEG findings were categorized into eight subgroups, and machine learning methods were utilized for classification. Three AI models—Multilayer Perceptron (MLP), Random Forest, and Support Vector Machine (SVM)—were employed. The dataset was further improved through data augmentation with SMOTE. The initial deep learning model achieved 89 % accuracy, recall, and F1 scores. Then, Optuna framework was incorporated into model to optimize hyperparameters, thus the accuracy reached 96 %. In comparison, the proposed ensemble model combining MLP, SVM and XGBoost achieved the highest accuracy of 98 %. The study demonstrates that data augmentation and ensemble AI models can provide robust decision support for physicians in classifying epilepsy types.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110470"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the electronic health record to identify and enroll people with epilepsy into a self-management program: Implementation and scalability in a clinical setting","authors":"Gena R. Ghearing ,&nbsp;Michael Privitera ,&nbsp;Maegan Tyrrell ,&nbsp;Lucy Mendoza ,&nbsp;David Ficker ,&nbsp;Dana LoTempio ,&nbsp;Mark Granner ,&nbsp;Clara Adeniyi ,&nbsp;Richard Barigye ,&nbsp;Jessica Black ,&nbsp;Farren Briggs ,&nbsp;Nicole Fiorelli ,&nbsp;Carrie Rogers ,&nbsp;Martha Sajatovic","doi":"10.1016/j.yebeh.2025.110461","DOIUrl":"10.1016/j.yebeh.2025.110461","url":null,"abstract":"<div><h3>Rationale</h3><div>“<strong><u>S</u></strong>elf-<strong><u>ma</u></strong>nagement for people with epilepsy and a histo<strong><u>r</u></strong>y of negative health even<strong><u>t</u></strong>s” (SMART) is an 8-week, remotely delivered, Epilepsy Self-Management (ESM) program. The ongoing EXPANDing self-management support in healthcare networks (EXPAND) initiative leveraged the Electronic Health Record (EHR) to identify SMART candidates, simplify recruitment, and reduce staff workload.</div></div><div><h3>Methods</h3><div>This is an ongoing implementation effort at two Level 4 Epilepsy Centers (Iowa and Cincinnati) using the Epic EHR which follows 9326 People With Epilepsy (PWE). The EHR uses pre-visit screening to identify PWE with a recent seizure; barriers to medication adherence; depression symptoms; age 18–25; or residence in rural regions. At outpatient visits, Epic generated a Best Practice Advisory (BPA). The clinician clicked the BPA to forward a referral or to signal either the patient declined or was not a candidate. The program aims to enroll 560 PWE.</div></div><div><h3>Results</h3><div>11 Nurse and Peer Educators received training. Within the first 5 months of BPA activation over 5000 clinician alerts were sent, 360 PWE were referred to SMART. Among 42 PWE who attended at least 1 SMART session, mean age was 35.0 (12.0), 57.5 % (N = 23) women. Mean past 30-day seizure count was 4.3 (10.0).</div></div><div><h3>Conclusions</h3><div>The EXPAND initiative, conducted in 2 Midwest U.S. epilepsy centers, is being successfully implemented to provide ESM to PWE. A widely available EHR has facilitated the referral process and remote delivery format allows for reach among diverse communities. This practical approach is amenable to scale-up and may be a model for expanding ESM access to PWE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110461"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life, academic self-concept, and mental health in children with epilepsy: The possible role of epilepsy comorbidities","authors":"Dana Buršíková Brabcová ,&nbsp;Adéla Otáhalová ,&nbsp;Jiří Kohout ,&nbsp;Michala Suleková ,&nbsp;Ivana Mašková ,&nbsp;Anežka Bělohlávková ,&nbsp;Pavel Kršek","doi":"10.1016/j.yebeh.2025.110471","DOIUrl":"10.1016/j.yebeh.2025.110471","url":null,"abstract":"<div><h3>Purpose</h3><div>Epilepsy in children is often associated with impaired quality of life, lower academic achievement, and reduced academic self-concept, as well as an increased risk of depression and anxiety. This study aims to evaluate the possible impact of comorbidities, such as learning disabilities (LD) and attention deficit hyperactivity disorder (ADHD), on these variables.</div></div><div><h3>Methods</h3><div>A total of 104 children with epilepsy (CWE) aged 8–15 years, attending mainstream schools, participated in the study. Of these, 45 were diagnosed with LD and/or ADHD. Participants completed the CHEQOL-25 questionnaire to assess quality of life (QoL), the SPAS questionnaire to evaluate academic self-concept, as well as inventories measuring depressive and anxiety symptoms. The data were analyzed to identify differences between subgroups with and without LD/ADHD using a two-sample <em>t</em>-test. Additionally, correlation analysis was conducted to identify other relevant variables influencing QoL, academic self-concept, and depressive and anxiety symptoms.</div></div><div><h3>Results</h3><div>QoL and academic self-concept were significantly poorer in CWE with LD/ADHD compared to those without comorbidities. QoL showed statistically significant associations with depressive and anxiety symptoms, and academic self-concept. While depressive symptoms levels in CWE without comorbidities align with those in the general population, CWE with LD/ADHD showed an increased association with depressive symptoms. Although anxiety symptoms were relatively strongly associated with depressive symptoms, their prevalence remains broadly comparable to that of children without epilepsy, regardless of the presence of LD/ADHD.</div></div><div><h3>Conclusion</h3><div>CWE with LD/ADHD and their families may benefit from focused attention, including targeted counseling and therapeutic interventions. However, specific interventional studies are recommended, based on child-specific findings.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110471"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dravet syndrome: Insights into seizure and speech progression from registry data","authors":"Margaux Delporte ,&nbsp;Johan Verbeeck ,&nbsp;Isabella Brambilla ,&nbsp;Georg Zimmermann ,&nbsp;Geert Molenberghs ,&nbsp;Rima Nabbout ,&nbsp;Residras Collaboration Group","doi":"10.1016/j.yebeh.2025.110459","DOIUrl":"10.1016/j.yebeh.2025.110459","url":null,"abstract":"<div><h3>Objective</h3><div>Dravet syndrome (DS) is a rare genetic developmental and epileptic encephalopathy syndrome characterized by refractory seizures and neurodevelopmental disorders beginning in infancy. This study aims to understand the natural history of DS by utilizing longitudinal data from patient registries.</div></div><div><h3>Methods</h3><div>We analysed data from 475 subjects across two European patient registries (RESIDRAS and Platform-RESIDRAS) from Dravet Italia Onlus, collected between 2010 and 2024. The study included only participants that were under 18 years old. Clinical characteristics such as seizure types and speech development were modelled using generalized linear mixed models and ordinal transition models.</div></div><div><h3>Results</h3><div>Unilateral seizures predominantly occurred during infancy and early childhood, while generalized convulsive and focal to bilateral tonic-clonic seizures increased with age, showing a higher incidence in boys. Focal seizures peaked around the age of three years before declining. Speech development varied, with most participants initially having poor speech. However, a considerable number of transitions between different levels of speech impairment were observed over time. Transition models indicated that once speech is acquired, the likelihood of losing this ability is negligible.</div></div><div><h3>Significance</h3><div>Patient registries are instrumental in modelling the disease history of DS, offering insight into its progression by means of advanced statistical modelling techniques that build on clinical expertise. Future research should focus on evaluating the effects of therapies and exploring the interrelations between different clinical characteristics. Understanding these aspects can guide better management strategies and improve patient outcomes.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110459"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steps towards seizure freedom with the use of Cenobamate","authors":"M. Toledo ,&nbsp;L. Abraira ,&nbsp;S. López-Maza ,&nbsp;B. Boy ,&nbsp;D. Campos-Fernández ,&nbsp;M. Quintana ,&nbsp;E. Santamarina ,&nbsp;E. Bellido ,&nbsp;E. Fonseca","doi":"10.1016/j.yebeh.2025.110464","DOIUrl":"10.1016/j.yebeh.2025.110464","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Cenobamate (CNB) is an antiseizure medication (ASM) that may change the prescription across the time. Our study sought to compare the rate of seizure-freedom patients after one year of CNB use experience in a single tertiary centre.</div></div><div><h3>Methods</h3><div>All patients with a minimum follow-up of one year who used CNB between 2021 and 2022 (n = 66) were compared to those who treated during 2023 (n = 126).</div></div><div><h3>Results</h3><div>In 2023, patients were older, used fewer concomitant ASMs (IQR 2–3 in 2023 vs 3–4 in 2022), and had a lower seizure frequency. Seizure-freedom rates at 12 months in 2021–2022 cohort were 16.7 %, and 23 % in 2023. The responder rate was greater than 60 % in both cohorts. The CNB titration was slower in the 2023 cohort, the median dose achieved was 225 mg in 2021–2022 and 200 mg in 2023. Concomitant ASMs were reduced in 70 % for both groups. The adverse event rate was nearly 60 %, most of them central nervous system-related. The CNB retention rate at 12 months was over 80 % in both groups. In 2023, up to 12 % of patients remained in monotherapy after 12 months.</div></div><div><h3>Conclusions</h3><div>This is the first real-world data series that compares the use of CNB in two cohorts of a single centre. One year follow-up seizure freedom rates above 20% can be achieved by a proper patient selection, CNB dose increase and ASM dose reduction, which eventually lead to CNB monotherapy in some cases.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110464"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application and new visualization techniques of 3D-quantitative motion analysis in epileptic seizures characterized by ictal automatic movements","authors":"Anna Mira Loesch-Biffar ,&nbsp;Tamás Karácsony ,&nbsp;Leah Sattlegger ,&nbsp;Christian Vollmar ,&nbsp;Jan Rémi ,&nbsp;João Paulo Silva Cunha ,&nbsp;Soheyl Noachtar","doi":"10.1016/j.yebeh.2025.110486","DOIUrl":"10.1016/j.yebeh.2025.110486","url":null,"abstract":"<div><h3>Purpose</h3><div>Our aim was to test the capability of the NeuroKinect 3D-method, as a movement visualization technique and quantitative analysis to differentiate ictal movements such as hyperkinetic and focal seizures with manual automatisms. The dataset is extracted from the NeuroKinect dataset, which is a RGB-D-IR dataset of epileptic seizures. The dataset is recorded with Kinect v2 and consists of RGB, Infrared (IR) and depth streams.</div><div>Quantitative 3D-movement analysis of 20 motor seizures was performed. Velocity, acceleration, jerk, covered distance, displacement and movement extent of Regions of Interests (= ROI: head, right hand, left hand and trunk) were captured.</div></div><div><h3>Results</h3><div>Among the analyzed seizures were 10 hyperkinetic (n = 7: 4 male, 3 female; mean age 39.6 years (SD ± 9.7)) and 10 focal seizures with manual automatisms (n = 10: 2 male, 8 female; mean age 39.2 years (SD ± 17.6)). Hyperkinetic seizures exhibited higher mean velocity in all ROIs (e.g. head = 0.62 ± 0.28 (m/s) vs. 0.12 ± 0.07 (m/s)) as well as higher mean acceleration and mean jerk in most ROIs; these differences were statistically significant. Mean movement extent, covered distance, and displacement for all ROIs were larger for hyperkinetic seizures, however not significantly. The duration of ictal movements (80 s ± 38 s versus 26 s ± 14 s; p = 0.001) was significantly longer in focal seizures with manual automatisms.</div></div><div><h3>Conclusions</h3><div>This new visualization technique allows to reconstruct tracked movement via 3D viewer and supports a 3D movement quantification which is capable to differentiate seizures characterized by movements, which may help to localize the epileptogenic zone.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"170 ","pages":"Article 110486"},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}