Epilepsy & Behavior最新文献

{"title":"Unlocking new frontiers in epilepsy through AI: From seizure prediction to personalized medicine","authors":"Majd A. AbuAlrob ,&nbsp;Adham Itbaisha ,&nbsp;Boulenouar Mesraoua","doi":"10.1016/j.yebeh.2025.110327","DOIUrl":"10.1016/j.yebeh.2025.110327","url":null,"abstract":"<div><div>Artificial intelligence (AI) is revolutionizing epilepsy care by advancing seizure detection, enhancing diagnostic precision, and enabling personalized treatment. Machine learning and deep learning technologies improve seizure monitoring, automate EEG analysis, and facilitate tailored therapeutic strategies, addressing the complexities of epilepsy management. However, challenges remain, including issues of model accuracy, interpretability, and applicability across diverse patient populations. Ethical considerations, such as safeguarding patient privacy, ensuring data security, and mitigating algorithmic bias, underscore the importance of responsible AI integration. Collaborative efforts among neurologists, data scientists, and regulatory authorities are critical to refining models, establishing ethical guidelines, and ensuring safe clinical adoption. This review examines AI’s transformative potential, its current limitations, and the multidisciplinary initiatives driving its effective implementation in epilepsy care.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"166 ","pages":"Article 110327"},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of status epilepticus among older adults – a prospective real-world study","authors":"Telma Assis ,&nbsp;Luan Côrtes ,&nbsp;Silas Santana ,&nbsp;Aroldo Bacellar","doi":"10.1016/j.yebeh.2025.110329","DOIUrl":"10.1016/j.yebeh.2025.110329","url":null,"abstract":"<div><div>Data on status epilepticus (SE) in older inpatients is limited.</div></div><div><h3>Aim</h3><div>To assess SE characteristics and etiologies, and <del>i</del>dentify risk factors for SE in a cohort of hospitalized patients.</div></div><div><h3>Methods</h3><div>We selected patients aged <span><math><mrow><mo>≥</mo></mrow></math></span> 60 years with late-onset seizures from a tertiary center. We analyzed demographics, clinical characteristics, etiology of seizures, neurological diseases, and comorbidities. We performed the Kaplan-Meier analysis to examine acute symptomatic and unprovoked seizures and multivariate logistic regression to identify risk factors for SE.</div></div><div><h3>Results</h3><div>We enrolled 236 patients (mean age: 77.1 ± 9.7 years [SD]) with acute symptomatic seizures, unprovoked seizures and both. SE occurred in 61 (25.8 %) patients. The mean age at the first-ever seizure was 76.5 ± 9.8 years. Females comprised 62.3 % of the patients in the SE group. Convulsive SE was the most common presentation (80.3 %). Cerebrovascular disorders were the most common etiology (27.9 %) among patients with SE. The likelihood of SE occurring was similar between patients with acute symptomatic seizures alone or in combination with unprovoked seizures (118/50 %), and those with unprovoked seizures (118/50 %). Dyslipidemia negatively correlated with SE (OR 0.45 [95 % CI, 0.24–0.85]; p = 0.014), perhaps due to statin use. Psychiatric disorders (OR 2.76 [95 % CI, 1.45–5.24]; <em>p</em> = 0.002;), sepsis (OR 2.33 [95 % CI, 1.13–4.79]; <em>p</em> = 0.021), and congestive heart failure (OR 2.95 [95 % CI,1.07–8.12]; <em>p</em> = 0.036) were risk factors for SE.</div></div><div><h3>Conclusion</h3><div>We identified older inpatients who developed SE, their characteristics, and the risk factors for developing SE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110329"},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic outcomes after mild-moderate traumatic brain injury in adult seizure-prone (FAST) and seizure-resistant (SLOW) rats: A model for understanding genetic contributions to acquired epileptogenesis?","authors":"Wai Lam Leung ,&nbsp;Ali Shad ,&nbsp;Piero Perucca ,&nbsp;Terence J. O’Brien ,&nbsp;Bridgette D. Semple ,&nbsp;Pablo M. Casillas-Espinosa","doi":"10.1016/j.yebeh.2025.110347","DOIUrl":"10.1016/j.yebeh.2025.110347","url":null,"abstract":"<div><div>Post-traumatic epilepsy (PTE) is a common, serious, long-term complication of traumatic brain injury (TBI). However, only a minority of individuals will develop epilepsy after a TBI, and the contribution of genetic predisposition to the risk of acquired epilepsy warrants further exploration. In this study, we examined whether innate, genetically determined differences in seizure susceptibility between seizure-prone FAST and seizure-resistant SLOW rat strains would influence chronic behavioral and PTE outcomes after experimental TBI. We hypothesized that FAST rats would show increased vulnerability to PTE and poorer neurobehavioral outcomes. Using the lateral fluid percussion injury model, we first determined the optimal injury parameters to generate a mild-moderate TBI in young adult FAST rats, which had previously shown high mortality to severe TBI. Then, FAST and SLOW rats underwent TBI or sham surgery, and a series of behavioral tests were performed either acutely (within 4 weeks) or chronically (more than 22 weeks) post-injury. Acutely, FAST rats showed an increased physiological response to TBI with a longer apnea duration, delayed pain response, and delayed self-righting, as well as increased acute seizure-like behavior compared to SLOW rats. Conversely, SLOW rats showed greater neuromotor deficits and weight loss sub-acutely compared to FAST rats. Chronically, while strain-specific phenotypes were observed (e.g., FAST rats showing increased anxiety-like behavior, altered nociceptive responses, and polydipsia), no TBI effects were detected. Analysis of continuous video-electroencephalographic recordings over a 1-month period starting at 6 months post-TBI did not reveal any spontaneous seizures. However, periodic epileptiform discharges were only found in FAST rats that had a TBI. Together, these findings reflect fundamental differences in chronic behavior and epileptiform discharges as a result of innate distinctions in epileptogenic susceptibility in FAST versus SLOW rats. However, a lack of spontaneous seizure activity or chronic neurobehavioral deficits in TBI animals confounded our ability to address the initial hypothesis, such that alternative injury models may be more suitable to study genetic contributions to the development of PTE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"166 ","pages":"Article 110347"},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between Body Mass Index and epilepsy","authors":"Yu-xuan Li ,&nbsp;Ruo-xia Chen ,&nbsp;Xue-rui Lv ,&nbsp;Qiang Zi ,&nbsp;Fu-mei Zhang ,&nbsp;Yun Li","doi":"10.1016/j.yebeh.2025.110295","DOIUrl":"10.1016/j.yebeh.2025.110295","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the clinical characteristics and influencing factors among epilepsy patients with varying Body Mass Index (BMI), and to propose new approaches for the prevention and treatment of epilepsy.</div></div><div><h3>Methods</h3><div>A total of 250 adult patients, newly diagnosed with epilepsy and not yet treated with antiepileptic drugs at the First Affiliated Hospital of Dali University between January 2017 and December 2022, were randomly selected as the experimental group. Additionally, 250 healthy individuals from the same period served as the control group to investigate the relationship between BMI and epilepsy. Univariate analysis and ordered multiple logistic regression were used to further identify factors influencing BMI in patients with epilepsy.</div></div><div><h3>Results</h3><div>A significant difference in BMI was found between adults newly diagnosed with epilepsy who had not yet used antiepileptic drugs, and healthy individuals (<em>P</em> = 0.001). The obesity rate was higher in epilepsy patients (20.4 %) compared to healthy adults (9.6 %).The ordered multiple logistic regression analysis revealed that gender(<em>P</em> = 0.003), age(<em>P</em> = 0.029), nation(<em>P</em> = 0.008), occupation(<em>P</em> &lt; 0.001), etiology(<em>P</em> = 0.001), NLR(<em>P</em> = 0.022), and SIRI(<em>P</em> = 0.008) were all significant factors influencing BMI in epilepsy patients.</div></div><div><h3>Conclusion</h3><div>People with epilepsy are more likely to also be obese and is associated with factors such as gender, age, nation, occupation, etiology, and inflammatory markers. In clinical practice, it is essential to monitor and manage BMI in epilepsy patients, identify preventable risk factors, and ultimately enhance treatment outcomes and quality of life.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110295"},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy management in primary healthcare: Knowledge, attitudes, and practices among health professionals in Palestine","authors":"Abeer Ghanayem ,&nbsp;Hussein Hallak","doi":"10.1016/j.yebeh.2025.110345","DOIUrl":"10.1016/j.yebeh.2025.110345","url":null,"abstract":"<div><h3>Background</h3><div>Primary healthcare practitioners play a key role in the comprehensive care of epilepsy. People with epilepsy require suitable guidance for self-management to enhance their health and well-being. The aim was to evaluate knowledge, attitudes, and practices about epilepsy management among the primary healthcare professionals.</div></div><div><h3>Methods</h3><div>Cross-sectional quantitative research was employed. Healthcare professionals working in primary healthcare clinics completed an online, self-administered questionnaire between April and June 2024.</div></div><div><h3>Results</h3><div>Three hundred valid questionnaires were analyzed. Healthcare professionals demonstrated moderate knowledge, favorable attitudes, and proactive practices in epilepsy management. Pearson’s correlation revealed a significant negative relationship between practices and knowledge (r = -0.170, p &lt; 0.01) and a positive association with attitudes (r = 0.279, p &lt; 0.01). Multivariate analysis showed that knowledge were negatively correlated with gender and specialty but positively with educational degree (OR = 0.640, 95 % CI: 1.260–0.020, p = 0.043; OR = 1.970, 95 % CI: 2.841–0.099, p &lt; 0.001). Attitudes were positively associated with age (OR = 2.552, 95 % CI: 0.974–4.130, p = 0.002) and years of experience (OR = 2.387, 95 % CI: 0.546–4.227, p = 0.011).</div></div><div><h3>Conclusions</h3><div>Findings indicate gaps in epilepsy knowledge, attitudes, and practices. The study underscores the need for comprehensive training initiatives in Palestine to enhance epilepsy management in primary healthcare settings.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"166 ","pages":"Article 110345"},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of an online epilepsy stigma self-management program","authors":"Seth A. Margolis ,&nbsp;Sarah Prieto ,&nbsp;Allyson Goldstein ,&nbsp;Sarah Kaden ,&nbsp;Elijah Castillo ,&nbsp;Shehjar Sadhu ,&nbsp;Dhaval Solanki ,&nbsp;Emma T. Larracey ,&nbsp;Geoffrey Tremont ,&nbsp;Kunal Mankodiya ,&nbsp;Elaine T. Kiriakopoulos","doi":"10.1016/j.yebeh.2025.110331","DOIUrl":"10.1016/j.yebeh.2025.110331","url":null,"abstract":"<div><h3>Introduction</h3><div>Stigma is a prevalent source of distress in people with epilepsy. We developed a self-paced online stigma self-management program for adults with epilepsy (Reducing Internalized Stigma in Epilepsy: A Behavioral Online Video Education, RISE ABOVE^TM).</div></div><div><h3>Materials and Methods</h3><div>Twenty socio-demographically diverse participants completed RISE ABOVE over an average of 3.5 weeks. Acceptability was determined by whether ≥ 80 % responded favorably to the Credibility and Expectancy Questionnaire and tailored surveys. Treatment Satisfaction was determined by whether mean Client Satisfaction Questionnaire responses was ≥ 80 %. Epilepsy Stigma, Perceived Stress, Perceived Rejection, Loneliness, Self-Efficacy, and Satisfaction with Social Roles and Activities were rated pre-post-intervention. Paired sample t-tests and Hedges’ g effect sizes gauged improvements.</div></div><div><h3>Results</h3><div>Most participants (≥ 80 %) thought the intervention was logical and content was easy to understand/navigate, interesting/helpful, and planned on using learned skills. Mean satisfaction was 85.41 % ± 14.43 %. There were large improvements in Epilepsy Stigma (p &lt; 0.001; Hedge’s g = 1.052), Perceived Stress (p &lt; 0.001; Hedge’s g = 0.887) and Satisfaction with Social Roles and Activities (p &lt; 0.001; Hedge’s g = -1.010), and medium improvements in Perceived Rejection (p = 0.004; Hedge’s g = 0.634) and Self-Efficacy (p = 0.008<em>;</em> Hedge’s g = -0.568). No significant differences were observed 6-months post-program completion, despite some attenuation.</div></div><div><h3>Conclusions</h3><div>RISE ABOVE is a feasible and acceptable anti-stigma intervention. Markers of acceptability were evident in high rates of credibility and satisfaction. Sizable improvements in stigma and other psychosocial outcomes were seen. Future studies will establish RISE ABOVE’s efficacy via a randomized controlled trial.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110331"},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical Coordinated Reset stimulation induces network desynchronization in an in vivo model of status epilepticus","authors":"Daniel Ehrens ,&nbsp;Fadi Aeed ,&nbsp;Yara Otor ,&nbsp;Vivek Charu ,&nbsp;Babak Razavi ,&nbsp;Sridevi V. Sarma ,&nbsp;Yitzhak Schiller ,&nbsp;Peter A. Tass","doi":"10.1016/j.yebeh.2025.110300","DOIUrl":"10.1016/j.yebeh.2025.110300","url":null,"abstract":"<div><div>Epilepsy, a neurological disorder characterized by recurrent seizures, profoundly impacts individuals worldwide. Various electrical stimulation protocols have been investigated to mitigate epileptic seizures, among which Coordinated Reset (CR) stimulation may have potential for inducing long-lasting neural desynchronization. This study explores the acute effects of CR stimulation on synchronization dynamics during Status Epilepticus (SE) in an in vivo animal model. An electrographically sustained seizure-state was induced via 4-aminopyridine (4AP) administration to CA3. Custom-designed electrode probes were implanted to facilitate simultaneous recording and electrical stimulation. Analytical univariate and bivariate features were constructed from the LFP time-series recording. Feature metrics focused on spike synchronization metrics and continuous signal analysis of amplitude, spectral power and phase synchronization across electrode pairs and frequency bands. Significance of modulation was assessed through permutation testing of the observed differences between the CR-stimulated group (N = 5) compared to the control (no stimulation) group (N = 3) during SE. Results showed overall decrease in amplitude and power univariate features, and a significant modulation of bivariate synchronization and connectivity measures across the spectrum between the CR stimulation and control group. Our findings underscore the potential effectiveness of CR stimulation in attenuating excessive neural synchronization, paving the way for further exploration of CR stimulation as a viable intervention for network desynchronization of epileptiform activity and subsequently treatment of seizures.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110300"},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic validation of a questionnaire for assessing the prevalence of epilepsy in Portugal","authors":"Carla Bentes ,&nbsp;Nuno Canas ,&nbsp;Cristina Pereira ,&nbsp;Manuela Santos ,&nbsp;Hugo Pedrosa ,&nbsp;Leonor Costa ,&nbsp;Ana Sofia Correia ,&nbsp;Fábio Pereira","doi":"10.1016/j.yebeh.2025.110344","DOIUrl":"10.1016/j.yebeh.2025.110344","url":null,"abstract":"<div><h3>Objective</h3><div>To present the results of the linguistic and cultural validation of two short questionnaires into Portuguese for use in interviews with the general population, adults, and parents/carers of epilepsy patients to assist in future epidemiological studies into the prevalence of epilepsy in Portugal.</div></div><div><h3>Methods</h3><div>The questionnaires were translated and validated using the ISPOR methodology. Two professional forward translators and one backtranslator were used to ensure the final translation was accurate, understandable, and culturally appropriate. The final translation was tested on six respondents from the target population and reviewed by the translation project manager and the medical steering committee before being proofread and finalized.</div></div><div><h3>Results</h3><div>The validation process was successful and resulted in a questionnaire that was culturally and linguistically relevant to the target population. The results show that the translations were produced in participant-friendly, clear and direct language that would be easily understandable by participants of any educational and social background. This was confirmed by the six respondents in the cognitive debriefing, who unanimously considered the questionnaires to be understandable and culturally appropriate.</div></div><div><h3>Conclusions</h3><div>Following successful linguistic and cultural validation, the Ottman et al. instrument for screening epilepsy is now available and validated for European Portuguese. The newly translated questionnaire paves the way for future research into epilepsy prevalence in Portugal and the Portuguese speaking countries.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110344"},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What do pharmacists know about epilepsy and antiseizure medications? − A survey among pharmacists in Norway","authors":"Cecilie Johannessen Landmark ,&nbsp;Samira Mashal ,&nbsp;Karen A. Boldingh Debernard ,&nbsp;Ellen Risvoll Sannes ,&nbsp;Katrine Heger ,&nbsp;Margrete Larsen Burns ,&nbsp;Oliver Henning","doi":"10.1016/j.yebeh.2025.110340","DOIUrl":"10.1016/j.yebeh.2025.110340","url":null,"abstract":"<div><h3>Background</h3><div>Approximately 45.000 persons in Norway have a diagnosis of epilepsy, a condition that may have a major impact on quality of life. Antiseizure medications (ASMs) are drugs with many pharmacological challenges. Pharmacists play an important role in the counselling of patients with chronic diseases. A recent initiative by the International League Against Epilepsy (ILAE) focuses on the active role of pharmacists in epilepsy care. This study aimed at evaluating the knowledge of Norwegian pharmacists on this subject and to identify possible knowledge gaps and need for further initiatives, education and training.</div></div><div><h3>Method</h3><div>A survey was developed based on previous studies and supplied with questions adapted to Norwegian pharmacists. Pharmacists were recruited through social media and members of pharmaceutical associations. The survey included socio-demographic and occupational information, questions on knowledge-based topics and the pharmacists’ sense of confidence.</div></div><div><h3>Results</h3><div>There were 113 responses, the majority from women (80%) working in community pharmacies (78%). The results showed an overall satisfactory level of knowledge about epilepsy, in line with similar surveys from other countries. In some more specific areas of ASMs, such as drug interactions, pharmacokinetic aspects, adverse effects and counselling patients, there is a need for improvement. Experience in counselling patients with epilepsy was significantly correlated with the pharmacists’ sense of confidence.</div></div><div><h3>Conclusion</h3><div>Pharmacists in Norway have a satisfactory level of knowledge and confidence in counselling regarding main issues of epilepsy and treatment with ASMs, but some knowledge gaps were identified. More educational opportunities to close these gaps may facilitate the pharmacist’s role in building health literacy for this patient group and improve drug safety.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110340"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral comorbidities of early-life seizures: Insights from developmental studies in rats","authors":"Andrea Grígelová ,&nbsp;Anna Mikulecká ,&nbsp;Hana Kubová","doi":"10.1016/j.yebeh.2025.110307","DOIUrl":"10.1016/j.yebeh.2025.110307","url":null,"abstract":"<div><div>Childhood epilepsy is frequently associated with neurobehavioral comorbidities such as depression, anxiety, cognitive impairments, and social dysfunction, as revealed by both clinical and experimental studies. Despite extensive neurophysiological research, behavioral studies in developing animals remain limited and underreported.</div><div>Here, we review the behavioral impact of early-life seizures (ELSs) in commonly used rat models in developmental studies. We outline suitable tests and provide guidance on how traditional tests should be adapted and interpreted in this context. Finally, we examine factors influencing behavioral analysis in developmental studies, exploring confounding variables and offering strategies to minimize their impact.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110307"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}