Epilepsy & Behavior最新文献

{"title":"Investigation of the relationship between Body Mass Index and epilepsy","authors":"Yu-xuan Li ,&nbsp;Ruo-xia Chen ,&nbsp;Xue-rui Lv ,&nbsp;Qiang Zi ,&nbsp;Fu-mei Zhang ,&nbsp;Yun Li","doi":"10.1016/j.yebeh.2025.110295","DOIUrl":"10.1016/j.yebeh.2025.110295","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the clinical characteristics and influencing factors among epilepsy patients with varying Body Mass Index (BMI), and to propose new approaches for the prevention and treatment of epilepsy.</div></div><div><h3>Methods</h3><div>A total of 250 adult patients, newly diagnosed with epilepsy and not yet treated with antiepileptic drugs at the First Affiliated Hospital of Dali University between January 2017 and December 2022, were randomly selected as the experimental group. Additionally, 250 healthy individuals from the same period served as the control group to investigate the relationship between BMI and epilepsy. Univariate analysis and ordered multiple logistic regression were used to further identify factors influencing BMI in patients with epilepsy.</div></div><div><h3>Results</h3><div>A significant difference in BMI was found between adults newly diagnosed with epilepsy who had not yet used antiepileptic drugs, and healthy individuals (<em>P</em> = 0.001). The obesity rate was higher in epilepsy patients (20.4 %) compared to healthy adults (9.6 %).The ordered multiple logistic regression analysis revealed that gender(<em>P</em> = 0.003), age(<em>P</em> = 0.029), nation(<em>P</em> = 0.008), occupation(<em>P</em> &lt; 0.001), etiology(<em>P</em> = 0.001), NLR(<em>P</em> = 0.022), and SIRI(<em>P</em> = 0.008) were all significant factors influencing BMI in epilepsy patients.</div></div><div><h3>Conclusion</h3><div>People with epilepsy are more likely to also be obese and is associated with factors such as gender, age, nation, occupation, etiology, and inflammatory markers. In clinical practice, it is essential to monitor and manage BMI in epilepsy patients, identify preventable risk factors, and ultimately enhance treatment outcomes and quality of life.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110295"},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy management in primary healthcare: Knowledge, attitudes, and practices among health professionals in Palestine","authors":"Abeer Ghanayem ,&nbsp;Hussein Hallak","doi":"10.1016/j.yebeh.2025.110345","DOIUrl":"10.1016/j.yebeh.2025.110345","url":null,"abstract":"<div><h3>Background</h3><div>Primary healthcare practitioners play a key role in the comprehensive care of epilepsy. People with epilepsy require suitable guidance for self-management to enhance their health and well-being. The aim was to evaluate knowledge, attitudes, and practices about epilepsy management among the primary healthcare professionals.</div></div><div><h3>Methods</h3><div>Cross-sectional quantitative research was employed. Healthcare professionals working in primary healthcare clinics completed an online, self-administered questionnaire between April and June 2024.</div></div><div><h3>Results</h3><div>Three hundred valid questionnaires were analyzed. Healthcare professionals demonstrated moderate knowledge, favorable attitudes, and proactive practices in epilepsy management. Pearson’s correlation revealed a significant negative relationship between practices and knowledge (r = -0.170, p &lt; 0.01) and a positive association with attitudes (r = 0.279, p &lt; 0.01). Multivariate analysis showed that knowledge were negatively correlated with gender and specialty but positively with educational degree (OR = 0.640, 95 % CI: 1.260–0.020, p = 0.043; OR = 1.970, 95 % CI: 2.841–0.099, p &lt; 0.001). Attitudes were positively associated with age (OR = 2.552, 95 % CI: 0.974–4.130, p = 0.002) and years of experience (OR = 2.387, 95 % CI: 0.546–4.227, p = 0.011).</div></div><div><h3>Conclusions</h3><div>Findings indicate gaps in epilepsy knowledge, attitudes, and practices. The study underscores the need for comprehensive training initiatives in Palestine to enhance epilepsy management in primary healthcare settings.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"166 ","pages":"Article 110345"},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of an online epilepsy stigma self-management program","authors":"Seth A. Margolis ,&nbsp;Sarah Prieto ,&nbsp;Allyson Goldstein ,&nbsp;Sarah Kaden ,&nbsp;Elijah Castillo ,&nbsp;Shehjar Sadhu ,&nbsp;Dhaval Solanki ,&nbsp;Emma T. Larracey ,&nbsp;Geoffrey Tremont ,&nbsp;Kunal Mankodiya ,&nbsp;Elaine T. Kiriakopoulos","doi":"10.1016/j.yebeh.2025.110331","DOIUrl":"10.1016/j.yebeh.2025.110331","url":null,"abstract":"<div><h3>Introduction</h3><div>Stigma is a prevalent source of distress in people with epilepsy. We developed a self-paced online stigma self-management program for adults with epilepsy (Reducing Internalized Stigma in Epilepsy: A Behavioral Online Video Education, RISE ABOVE^TM).</div></div><div><h3>Materials and Methods</h3><div>Twenty socio-demographically diverse participants completed RISE ABOVE over an average of 3.5 weeks. Acceptability was determined by whether ≥ 80 % responded favorably to the Credibility and Expectancy Questionnaire and tailored surveys. Treatment Satisfaction was determined by whether mean Client Satisfaction Questionnaire responses was ≥ 80 %. Epilepsy Stigma, Perceived Stress, Perceived Rejection, Loneliness, Self-Efficacy, and Satisfaction with Social Roles and Activities were rated pre-post-intervention. Paired sample t-tests and Hedges’ g effect sizes gauged improvements.</div></div><div><h3>Results</h3><div>Most participants (≥ 80 %) thought the intervention was logical and content was easy to understand/navigate, interesting/helpful, and planned on using learned skills. Mean satisfaction was 85.41 % ± 14.43 %. There were large improvements in Epilepsy Stigma (p &lt; 0.001; Hedge’s g = 1.052), Perceived Stress (p &lt; 0.001; Hedge’s g = 0.887) and Satisfaction with Social Roles and Activities (p &lt; 0.001; Hedge’s g = -1.010), and medium improvements in Perceived Rejection (p = 0.004; Hedge’s g = 0.634) and Self-Efficacy (p = 0.008<em>;</em> Hedge’s g = -0.568). No significant differences were observed 6-months post-program completion, despite some attenuation.</div></div><div><h3>Conclusions</h3><div>RISE ABOVE is a feasible and acceptable anti-stigma intervention. Markers of acceptability were evident in high rates of credibility and satisfaction. Sizable improvements in stigma and other psychosocial outcomes were seen. Future studies will establish RISE ABOVE’s efficacy via a randomized controlled trial.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110331"},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical Coordinated Reset stimulation induces network desynchronization in an in vivo model of status epilepticus","authors":"Daniel Ehrens ,&nbsp;Fadi Aeed ,&nbsp;Yara Otor ,&nbsp;Vivek Charu ,&nbsp;Babak Razavi ,&nbsp;Sridevi V. Sarma ,&nbsp;Yitzhak Schiller ,&nbsp;Peter A. Tass","doi":"10.1016/j.yebeh.2025.110300","DOIUrl":"10.1016/j.yebeh.2025.110300","url":null,"abstract":"<div><div>Epilepsy, a neurological disorder characterized by recurrent seizures, profoundly impacts individuals worldwide. Various electrical stimulation protocols have been investigated to mitigate epileptic seizures, among which Coordinated Reset (CR) stimulation may have potential for inducing long-lasting neural desynchronization. This study explores the acute effects of CR stimulation on synchronization dynamics during Status Epilepticus (SE) in an in vivo animal model. An electrographically sustained seizure-state was induced via 4-aminopyridine (4AP) administration to CA3. Custom-designed electrode probes were implanted to facilitate simultaneous recording and electrical stimulation. Analytical univariate and bivariate features were constructed from the LFP time-series recording. Feature metrics focused on spike synchronization metrics and continuous signal analysis of amplitude, spectral power and phase synchronization across electrode pairs and frequency bands. Significance of modulation was assessed through permutation testing of the observed differences between the CR-stimulated group (N = 5) compared to the control (no stimulation) group (N = 3) during SE. Results showed overall decrease in amplitude and power univariate features, and a significant modulation of bivariate synchronization and connectivity measures across the spectrum between the CR stimulation and control group. Our findings underscore the potential effectiveness of CR stimulation in attenuating excessive neural synchronization, paving the way for further exploration of CR stimulation as a viable intervention for network desynchronization of epileptiform activity and subsequently treatment of seizures.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110300"},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic validation of a questionnaire for assessing the prevalence of epilepsy in Portugal","authors":"Carla Bentes ,&nbsp;Nuno Canas ,&nbsp;Cristina Pereira ,&nbsp;Manuela Santos ,&nbsp;Hugo Pedrosa ,&nbsp;Leonor Costa ,&nbsp;Ana Sofia Correia ,&nbsp;Fábio Pereira","doi":"10.1016/j.yebeh.2025.110344","DOIUrl":"10.1016/j.yebeh.2025.110344","url":null,"abstract":"<div><h3>Objective</h3><div>To present the results of the linguistic and cultural validation of two short questionnaires into Portuguese for use in interviews with the general population, adults, and parents/carers of epilepsy patients to assist in future epidemiological studies into the prevalence of epilepsy in Portugal.</div></div><div><h3>Methods</h3><div>The questionnaires were translated and validated using the ISPOR methodology. Two professional forward translators and one backtranslator were used to ensure the final translation was accurate, understandable, and culturally appropriate. The final translation was tested on six respondents from the target population and reviewed by the translation project manager and the medical steering committee before being proofread and finalized.</div></div><div><h3>Results</h3><div>The validation process was successful and resulted in a questionnaire that was culturally and linguistically relevant to the target population. The results show that the translations were produced in participant-friendly, clear and direct language that would be easily understandable by participants of any educational and social background. This was confirmed by the six respondents in the cognitive debriefing, who unanimously considered the questionnaires to be understandable and culturally appropriate.</div></div><div><h3>Conclusions</h3><div>Following successful linguistic and cultural validation, the Ottman et al. instrument for screening epilepsy is now available and validated for European Portuguese. The newly translated questionnaire paves the way for future research into epilepsy prevalence in Portugal and the Portuguese speaking countries.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110344"},"PeriodicalIF":2.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What do pharmacists know about epilepsy and antiseizure medications? − A survey among pharmacists in Norway","authors":"Cecilie Johannessen Landmark ,&nbsp;Samira Mashal ,&nbsp;Karen A. Boldingh Debernard ,&nbsp;Ellen Risvoll Sannes ,&nbsp;Katrine Heger ,&nbsp;Margrete Larsen Burns ,&nbsp;Oliver Henning","doi":"10.1016/j.yebeh.2025.110340","DOIUrl":"10.1016/j.yebeh.2025.110340","url":null,"abstract":"<div><h3>Background</h3><div>Approximately 45.000 persons in Norway have a diagnosis of epilepsy, a condition that may have a major impact on quality of life. Antiseizure medications (ASMs) are drugs with many pharmacological challenges. Pharmacists play an important role in the counselling of patients with chronic diseases. A recent initiative by the International League Against Epilepsy (ILAE) focuses on the active role of pharmacists in epilepsy care. This study aimed at evaluating the knowledge of Norwegian pharmacists on this subject and to identify possible knowledge gaps and need for further initiatives, education and training.</div></div><div><h3>Method</h3><div>A survey was developed based on previous studies and supplied with questions adapted to Norwegian pharmacists. Pharmacists were recruited through social media and members of pharmaceutical associations. The survey included socio-demographic and occupational information, questions on knowledge-based topics and the pharmacists’ sense of confidence.</div></div><div><h3>Results</h3><div>There were 113 responses, the majority from women (80%) working in community pharmacies (78%). The results showed an overall satisfactory level of knowledge about epilepsy, in line with similar surveys from other countries. In some more specific areas of ASMs, such as drug interactions, pharmacokinetic aspects, adverse effects and counselling patients, there is a need for improvement. Experience in counselling patients with epilepsy was significantly correlated with the pharmacists’ sense of confidence.</div></div><div><h3>Conclusion</h3><div>Pharmacists in Norway have a satisfactory level of knowledge and confidence in counselling regarding main issues of epilepsy and treatment with ASMs, but some knowledge gaps were identified. More educational opportunities to close these gaps may facilitate the pharmacist’s role in building health literacy for this patient group and improve drug safety.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110340"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral comorbidities of early-life seizures: Insights from developmental studies in rats","authors":"Andrea Grígelová ,&nbsp;Anna Mikulecká ,&nbsp;Hana Kubová","doi":"10.1016/j.yebeh.2025.110307","DOIUrl":"10.1016/j.yebeh.2025.110307","url":null,"abstract":"<div><div>Childhood epilepsy is frequently associated with neurobehavioral comorbidities such as depression, anxiety, cognitive impairments, and social dysfunction, as revealed by both clinical and experimental studies. Despite extensive neurophysiological research, behavioral studies in developing animals remain limited and underreported.</div><div>Here, we review the behavioral impact of early-life seizures (ELSs) in commonly used rat models in developmental studies. We outline suitable tests and provide guidance on how traditional tests should be adapted and interpreted in this context. Finally, we examine factors influencing behavioral analysis in developmental studies, exploring confounding variables and offering strategies to minimize their impact.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110307"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sex on neuropsychiatric comorbidities in childhood epilepsy","authors":"Nicholas Krant ,&nbsp;Casey D. Krueger ,&nbsp;Ana Carissa L. Homick,&nbsp;Claudia A. Tarrant,&nbsp;Gregory L. Holmes","doi":"10.1016/j.yebeh.2025.110328","DOIUrl":"10.1016/j.yebeh.2025.110328","url":null,"abstract":"<div><h3>Objective</h3><div>Neuropsychiatric comorbidities are prevalent in children with epilepsy and often pose greater concerns than the seizures themselves. Identifying children at risk for these conditions is crucial for developing effective therapies. In prepubescent rodents, sex significantly influences cognitive dysfunction related to seizures, with prepubescent male rats exhibiting more severe adverse effects than females. However, it remains unclear whether sex plays a similar role in cognitive and behavioral outcomes in children. This review aims to assess the literature on whether sex is a biological factor affecting behavioral and cognitive outcomes in pediatric epilepsy.</div></div><div><h3>Materials and Methods</h3><div>We conducted a literature review to explore the impact of sex on cognitive and behavioral outcomes in children (up to age 18 years) with epilepsy of all types. Studies were categorized into observational and interventional types. We analyzed population studies involving children with epilepsy, as well as those addressing genetic factors, surgical interventions, status epilepticus, infantile spasms, pharmacological treatments, and the ketogenic diet.</div></div><div><h3>Results</h3><div>Few adequately powered studies have examined sex as a biological variable in relation to cognitive and behavioral impairments in children with epilepsy. In addition, many studies failed to examine sex-related differences in behavior and cognition in children without epilepsy. Generally, the sex-related differences in cognitive and behavioral impairments in children with epilepsy match those seen in children without epilepsy. One exception is that in several studies girls with epilepsy had a similar risk for attention deficit hyperactive disorder (ADHD) as boys, whereas in children without epilepsy ADHD is more common in boys than girls. Although there is a modest trend indicating worse cognitive outcomes for boys with epilepsy compared to girls, consistency across studies is lacking.</div></div><div><h3>Conclusion</h3><div>Sex is not yet a well-explored prognostic factor for outcomes following childhood epilepsy, though some small differences were identified for specific outcomes. More rigorously designed studies are necessary to report outcomes by sex while controlling for potential confounders. The variability in methods for assessing neurodevelopmental outcomes underscores the need for standardized and comprehensive evaluations of cognitive and behavior in children with epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110328"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness of two video-based educational interventions to enhance knowledge about epilepsy in preschool children","authors":"Dana Buršíková Brabcová ,&nbsp;Jiří Kohout ,&nbsp;Ivana Mašková ,&nbsp;Kateřina Lohrová","doi":"10.1016/j.yebeh.2025.110339","DOIUrl":"10.1016/j.yebeh.2025.110339","url":null,"abstract":"<div><h3>Objectives</h3><div>Current research affirms that sufficiently high knowledge about epilepsy is crucial for reducing stigmatization and improving the quality of life for people with epilepsy. While educational interventions targeting older children, adolescents, and adults are relatively common, there is a notable lack of approaches suitable for preschool children. Building on our previous research, which focused on educational interventions using a game and a story, this study aims to evaluate the effectiveness of two video-based interventions, <em>Campi the Seahorse</em> and <em>Adventure While Fishing</em>, in children aged 5–6 years with no prior knowledge about epilepsy.</div></div><div><h3>Methods</h3><div>A total of 199 children participated in two intervention studies. Knowledge about epilepsy was assessed through interviews using an 11-item test that had been successfully employed in our previous intervention studies, demonstrating satisfactory internal consistency and construct validity. The level of knowledge was evaluated immediately after each intervention and one month later. Additionally, satisfaction with the intervention and its potential impact on epilepsy-related stigma were measured using a smiley-face scale.</div></div><div><h3>Results</h3><div>The <em>Adventure While Fishing</em> intervention demonstrated notable effectiveness compared to our previously developed intervention using an educational story. Its impact was also significant when compared to the level of knowledge observed in children aged 9–11 years with no prior exposure to epilepsy-related interventions. In contrast, the outcomes of the <em>Campi the Seahorse</em> intervention were significantly poorer across all comparisons, likely due to its insufficient coverage of key aspects of the topic.</div></div><div><h3>Conclusions</h3><div>The results indicated that the <em>Adventure While Fishing</em> intervention was an effective approach to establishing basic knowledge about epilepsy within the targeted age group. In contrast, the <em>Campi the Seahorse</em> intervention would require further extension and/or modification to achieve sufficient effectiveness for this purpose.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110339"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unseen yet overcounted: The paradox of seizure frequency reporting","authors":"Victoria Wong ,&nbsp;Timothy Hannon ,&nbsp;Kiran M. Fernandes ,&nbsp;Mark J. Cook ,&nbsp;Ewan S. Nurse","doi":"10.1016/j.yebeh.2025.110335","DOIUrl":"10.1016/j.yebeh.2025.110335","url":null,"abstract":"<div><h3>Objective</h3><div>Seizure control is often assessed using patient-reported seizure frequencies. Despite its subjectivity, self-reporting remains essential for guiding anti-seizure medication (ASM) decisions and ongoing patient investigations. This study aims to compare patient-reported seizure frequencies with electrographic frequencies captured via ambulatory video EEG (avEEG).</div></div><div><h3>Methods</h3><div>Data from intake forms and seizure diaries were collected from patients undergoing home-based avEEG in Australia (April 2020–April 2022). Intake forms included monthly seizure frequency estimates. Only avEEG-confirmed epilepsy cases were analyzed. Univariate and multivariate analyses compared seizure frequencies reported via EEG, diaries, and surveys.</div></div><div><h3>Results</h3><div>Of 3,407 reports, 853 identified epilepsy cases, with 234 studies analyzed after excluding outliers. Diary-reported frequencies correlated with EEG frequency (p &lt; 0.00001), but survey-reported frequencies did not (p &gt; 0.05). Surveys significantly overestimated true seizure frequency (median = 3.98 seizures/month, p &lt; 0.0001), while diaries showed substantially smaller differences (median = 0.01 seizures/month, p &lt; 0.0001). Carer presence was associated with higher diary-reported frequencies (p = 0.047). Age negatively correlated with survey frequency estimation error (p = 0.016). Multivariate analysis identified age and carer status as significant predictors of residuals.</div></div><div><h3>Conclusions</h3><div>Most patients overestimate their true seizure frequency, potentially influencing therapeutic decisions and raising concerns about the reliability of some participants and carers to self-report seizures in clinical trials.</div></div><div><h3>Significance</h3><div>An “over-reporting, over-prescribing” cascade may affect epilepsy treatment and highlights the potential issue of clinical drug trials relying on self-reported seizure rates for primary endpoints.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110335"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}