Epilepsy & Behavior最新文献

{"title":"Evaluating the Status Epilepticus in Pediatric patients Severity Score (STEPSS): A systematic review and meta-analysis","authors":"Xinchi Li ,&nbsp;Bowen Han ,&nbsp;Tianhao Wu ,&nbsp;Tu Chen ,&nbsp;Guiling Wang ,&nbsp;Heng Zhang","doi":"10.1016/j.yebeh.2025.110445","DOIUrl":"10.1016/j.yebeh.2025.110445","url":null,"abstract":"<div><h3>Objective</h3><div>The Status Epilepticus in Pediatric patients Severity Score (STEPSS) has been utilized to assess outcomes in children with status epilepticus (SE). This study aims to evaluate STEPSS’s diagnostic efficacy in predicting survival outcomes for SE patients.</div></div><div><h3>Methods</h3><div>A meta-analysis was conducted to address this objective, calculating pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve (AUC), Relative Risk (RR) and corresponding 95 % confidence intervals (95 % CI). Subgroup analysis, meta-regression analysis and the Deek’s plot were used to evaluate heterogeneity.</div></div><div><h3>Results</h3><div>Eight article met inclusion criteria. The literature exhibited non-threshold effect-caused heterogeneity. Pooled sensitivity and specificity, using a random-effects model, were 0.82 (95 % CI: 0.71, 0.90) and 0.78 (95 % CI: 0.70, 0.85), respectively. DOR was 18 (95 % CI: 8, 43), and the Summary Receiver Operating Characteristic AUC (SROC-AUC) was 0.85. Pooled RR showed that the accuracy of using STEPSS for SE diagnosis was 10.74 times higher than without using it (RR = 10.74, 95 % CI: 6.12, 18.86).</div></div><div><h3>Conclusion</h3><div>STEPSS demonstrates strong predictive efficacy for pediatric SE, supporting its diagnostic use in children.</div></div><div><h3>Significance</h3><div>These findings moderately validate STEPSS’s utility in predicting outcomes in pediatric SE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110445"},"PeriodicalIF":2.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor concerning “The effects of Reiki application on sleep and quality of life in patients with epilepsy”","authors":"Thomas J. Wheeler","doi":"10.1016/j.yebeh.2025.110435","DOIUrl":"10.1016/j.yebeh.2025.110435","url":null,"abstract":"","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110435"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of the feasibility and efficacy of an online group memory strategy training program for adults with epilepsy","authors":"Mary Lou Smith ,&nbsp;Elizabeth N. Kerr ,&nbsp;Mary Pat McAndrews ,&nbsp;Rosalee Smith ,&nbsp;Susan Hayman-Abello ,&nbsp;Sahil Patel ,&nbsp;David Gold","doi":"10.1016/j.yebeh.2025.110443","DOIUrl":"10.1016/j.yebeh.2025.110443","url":null,"abstract":"<div><div>Memory deficits are a common comorbidity in epilepsy and memory rehabilitation has been identified as a priority treatment need by adults with epilepsy. This study investigated the impact of an online group intervention, Strategies for Epilepsy and Memory (STREAM), on self-reported perception and satisfaction with memory and use of strategies to mitigate memory failures in everyday life. The program consisted of eight, weekly, one-hour sessions that provided education on memory, strategies and how to implement them, and life-style factors that influence memory. Twenty-seven adults (mean age 43.3 yrs) completed the Multifactorial Memory Questionnaire at baseline and again at 2 weeks and 3 months following completion of STREAM. Scores increased after participation in STREAM and these increases were maintained at follow-up, indicating success of the program in improving self-perceptions of memory and the use of strategies. Participants valued the educational aspects of the program as well as the support received from others sharing similar experiences with epilepsy. The results suggest that this format of memory rehabilitation is both feasible and effective, and set the stage for future randomized control trials.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110443"},"PeriodicalIF":2.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Looking beyond epilepsy management: The impact of mental health, quality of life, and transition-readiness on transition-aged adolescents with epilepsy and varying cognitive abilities","authors":"Sarah A. Healy ,&nbsp;Maryam Nabavi-Nouri ,&nbsp;Juan Toro-Perez ,&nbsp;Nicholas Mitsakakis ,&nbsp;Andrea Andrade ,&nbsp;Sharon Whiting ,&nbsp;Katherine Muir","doi":"10.1016/j.yebeh.2025.110429","DOIUrl":"10.1016/j.yebeh.2025.110429","url":null,"abstract":"<div><h3>Objectives</h3><div>Clinicians, researchers, and families consistently agree on the importance of transition clinics for adolescents with epilepsy. In order to ensure that all adolescents have a successful transition, it is important to consider and address the unique needs of each adolescent. The literature suggests that adolescents with varying cognitive abilities may have different needs when preparing for transition. In order to explore this further, this study aimed to better understand the unique psychosocial needs of adolescents with typical cognitive development, mild intellectual disability (MID), and of caregivers of adolescents with moderate-to-severe ID.</div></div><div><h3>Methods</h3><div>Baseline mental health, QoL, and transition readiness data from 231 transition-aged adolescents (aged 14 to 18) enrolled in an epilepsy transition clinic were analyzed for this study. For analyses, adolescents were separated by cognitive ability.</div></div><div><h3>Results</h3><div>Results showed that adolescents with differing cognitive abilities had different needs. Adolescents with typical cognitive development did not have all the skills needed for a successful transition, suggesting the need for more epilepsy education. Adolescents with MID had significantly fewer transition skills, suggesting the need for more accessible epilepsy information and education. Mental health comorbidities were significant considerations for both of these groups. When looking at caregivers of adolescents with moderate-to-severe cognitive impairment, results suggest that although they have necessary transition skills, they require supports in other areas.</div></div><div><h3>Significance</h3><div>In order to ensure best outcomes for these adolescents, it may be important to develop separate transition guidelines and programs for adolescents with differing cognitive abilities; helping to ensure that the needs of all adolescents are addressed.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110429"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The awareness, attitudes and knowledge of neurologists in Hungary on sudden unexpected death in epilepsy (SUDEP)","authors":"Nandan Ravichandra ,&nbsp;Anna Kelemen ,&nbsp;Joanne McCabe ,&nbsp;Zsofia Jordan ,&nbsp;Moran Kanaan ,&nbsp;Rohit Shankar","doi":"10.1016/j.yebeh.2025.110442","DOIUrl":"10.1016/j.yebeh.2025.110442","url":null,"abstract":"<div><h3>Background</h3><div>A leading cause of epilepsy mortality is Sudden Unexpected Death in Epilepsy (SUDEP). All international epilepsy guidelines encourage clinicians to discuss SUDEP with people with epilepsy (PWE). However, implementation of this guidance has been ambiguous depending on the country in question. This is inspite of overwhelming wishes from PWE for their clinician to discuss it with them. There has been no study to inquire into the knowledge, awareness and attitudes towards SUDEP communication in epilepsy professionals in Hungary (population: 9.6 million).</div></div><div><h3>Objective</h3><div>We investigated neurologists and paediatric neurologists views in Hungary on SUDEP counselling.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey of 20 questions many Likert style using validated themes was disseminated among doctors working with PWE, registered to the Hungarian chapter of the International League Against Epilepsy (ILAE). A non-discriminatory exponential snowballing technique leading to non-probability sampling was used to disseminate the survey to all ILAE members. Questions revolved around SUDEP communication and counselling. Descriptive statistics were used for analysis.</div></div><div><h3>Results</h3><div>Of 58 respondents from 271 ILAE members, 43.1 % respondents had over 15 years of experience, and 44.8 % felt communicating and counseling their PWE of SUDEP is an important aspect of their role. One person (1.7 %) told of discussing SUDEP with all PWE while 22.4 % mentioned they do not talk of SUDEP to any PWE.</div></div><div><h3>Conclusion</h3><div>Despite well established guidelines asserting the need to discuss SUDEP with all PWE, epilepsy professionals in Hungary are not doing so. This is consistent with other European countries on the same subject.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110442"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating effects of anxiety and depression on the relationship between somatic symptom disorder and quality of life among adults with epilepsy","authors":"Xueping Ma ,&nbsp;Sisi Shen ,&nbsp;Jia Xu ,&nbsp;Rong Yang ,&nbsp;Jinmei Li ,&nbsp;Dong Zhou","doi":"10.1016/j.yebeh.2025.110432","DOIUrl":"10.1016/j.yebeh.2025.110432","url":null,"abstract":"<div><h3>Objective</h3><div>Although quality of life (QOL) is impaired in patients with somatic symptom disorder (SSD), little is known about the relationship between SSD and QOL among patients with epilepsy (PWE) and the mechanisms underlying this association. This study aimed to identify the mediators of the association between SSD and QOL among PWE.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at West China Hospital between July 2020 and May 2022. A total of 749 adults with epilepsy who attended the epilepsy center were consecutively enrolled via convenience sampling. All patients completed questionnaires that assessed demographic and clinical features, the Somatic Symptom Disorder-B Criteria Scale (SSD-12), the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), and the National Hospital Seizure Severity Scale (NHS3). The direct, indirect, and total effects of the predictors on QOL among PWE were tested based on the bootstrap method.</div></div><div><h3>Results</h3><div>Up to 24.43 % of the adults with epilepsy were affected by SSD. Patients with SSD had significantly higher levels of depression and anxiety and lower levels of QOL. Correlation and mediation analyses revealed that the negative relationship between SSD and QOL was partially mediated by depression and anxiety (<em>B</em> = -10.412, 95 % <em>CI</em> [-12.730, −8.343]). The indirect effect accounted for 66.76 % of the total effect, among which depression accounted for a greater proportion (46.37 %).</div></div><div><h3>Conclusion</h3><div>This study offers new insight into the mechanism underlying the association between SSD and QOL among PWE. Interventions aimed at increasing QOL in patients with somatic symptoms should consider screening and treating depression and anxiety.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110432"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensative inter-module functional connectivity enhancement at the latter half of verbal fluency task in patients with temporal lobe epilepsy","authors":"Juan Li ,&nbsp;Fangfang Xie ,&nbsp;Wen Chai ,&nbsp;Chaorong Liu ,&nbsp;Langzi Tan ,&nbsp;Jialinzi He ,&nbsp;Xianghe Liu ,&nbsp;Ge Wang ,&nbsp;Min Zhang ,&nbsp;Haiyun Tang ,&nbsp;Danlei Wei ,&nbsp;Zhuanyi Yang ,&nbsp;Bo Xiao ,&nbsp;Lili Long ,&nbsp;Kangrun Wang","doi":"10.1016/j.yebeh.2025.110437","DOIUrl":"10.1016/j.yebeh.2025.110437","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies proposed that disrupted dynamic interaction between language subsystems diminishes temporal lobe epilepsy (TLE) patients’ adaptability to changing cognitive loads. However, how the interaction is dynamically performed remained unclear. Due to the graphic syllabic logographic nature of Chinese characters, the Chinese Character verbal fluency (VFC) task provides changing demands throughout the task, being an ideal tool to analyze the dynamic interaction of language subsystems.</div></div><div><h3>Methods</h3><div>Twenty-nine neurotypical controls and 58 patients with TLE from an ongoing cohort participated in this study. Functional MRI data was collected while participants performed a Chinese verbal fluency task. Functional connectivity alteration from the first to the second half of the task block were compared between controls and patients. Regions with significant functional connectivity changes are clustered into modules. The recruitment and integration of modules were calculated with sliding-window approaches and compared.</div></div><div><h3>Results</h3><div>We captured the left frontal and anterior temporal lobe modules. The functional connectivity between the left frontal and anterior temporal modules was enhanced in the latter half of the VFC task in patients but not controls (p &lt; 0.05, FDR-corrected). Meanwhile, TLE’s functional connectivity within the anterior temporal module was impaired throughout the task (p = 0.04), and the two modules were more integrated in patients (p = 0.008). Intermodular connectivity enhancement in patients was correlated with better verbal fluency performance (p = 0.03, FDR-corrected).</div></div><div><h3>Conclusion</h3><div>We observed diminished intramodular and enhanced intermodular dynamic functional connectivity in patients with TLE. The enhanced intermodular functional connectivity at the latter half of the task represents a compensative process, a potential intervention target for language decline in TLE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110437"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive use of cannabidiol in pediatric drug-resistant epilepsy: A retrospective multicenter analysis","authors":"Ermekbaeva Aizara ,&nbsp;T.Varughese Robin ,&nbsp;Li Hanna ,&nbsp;Urbina Lopez Amy ,&nbsp;Milosh Brooke ,&nbsp;Philip Rebecca ,&nbsp;Suri Christian ,&nbsp;Shah Yash ,&nbsp;Kothare Sanjeev","doi":"10.1016/j.yebeh.2025.110426","DOIUrl":"10.1016/j.yebeh.2025.110426","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy affects approximately 70 million people globally, with one-third experiencing drug-resistant epilepsy (DRE). Cannabidiol (CBD) has shown promise in reducing seizure frequency for specific epilepsy syndromes, though data for broader etiologies remain limited. The goal of the study is to evaluate the effectiveness of CBD as an adjunct treatment in the reduction of seizure frequency in DRE patients of various etiologies.</div></div><div><h3>Methods</h3><div>We conducted a retrospective chart review of patients with refractory epilepsy who received a CBD as an adjunct treatment at two tertiary care centers. Seizure frequency at the start of CBD treatment and at a minimum follow-up of 3 months was recorded. Epilepsy diagnosis was categorized into five groups: Focal/Multifocal Epilepsy, Primary Generalized Epilepsy, Lennox-Gastaut Syndrome, Dravet Syndrome, and Other Developmental and Epileptic Encephalopathies.</div></div><div><h3>Results</h3><div>Among all patients, 49 % achieved a ≤ 25 % reduction in seizures, while 5 % had a 26–50 % reduction, 21 % reached a 51–75 % reduction, 20 % experienced a 76–99 % reduction, and 5 % achieved near seizure freedom. There was a significant reduction in median seizure frequency from 30 at baseline to 8 post-treatment (p = 0.000). Significant reductions in seizure frequency were also observed within each diagnostic category.</div></div><div><h3>Discussion</h3><div>CBD has proven to be an effective adjunctive treatment for medically refractory epilepsy, showing significant efficacy across various epilepsy etiologies and genetic backgrounds. Its ability to reduce seizure frequency and the burden of anti-seizure medications (ASMs), especially in syndromes that are traditionally difficult to manage, highlights its value as an additional therapeutic option.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110426"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcome of ceasing valproate before pregnancy in women with epilepsy","authors":"Frank Vajda ,&nbsp;Terence O’Brien ,&nbsp;Janet Graham ,&nbsp;Alison Hitchcock ,&nbsp;Piero Perucca ,&nbsp;Cecilie Lander ,&nbsp;Mervyn Eadie","doi":"10.1016/j.yebeh.2025.110441","DOIUrl":"10.1016/j.yebeh.2025.110441","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the effects of pre-pregnancy withdrawal of valproate therapy in women with epilepsy in relation to the risk of giving birth to a malformed foetus and of losing seizure control.</div></div><div><h3>Results</h3><div>Data from the Australian Pregnancy Register were compared between 128 pregnancies in women with epilepsy where valproate intake had been ceased before conception and 448 pregnancies where the drug was continued in unchanged dosage at least until well into pregnancy. Malformed foetuses occurred in 5.5 % of the valproate-withdrawn pregnancies and 13.0 % of the valproate unchanged ones (O.R. = 0.389; 95 % C.I. 0.173, 0.875). Complete freedom from seizures throughout pregnancy occurred in 53.9 % of the valproate-withdrawal pregnancies and 61.6 % of the valproate continuing ones (O.R. = 0.729; 95 % C.I. 0.490, 1.083). Differences in seizure freedom rates throughout pregnancy between these two groups approached statistical significance to a greater degree in the subset of 407 pregnancies from women with generalised epilepsies (53.9 % vs 64.4 %, O.R. = 0.644; 95 % C.I. 0.391–1.061).</div></div><div><h3>Conclusions</h3><div>In the pregnancies of women with epilepsy that were studied, pre-conception valproate withdrawal yielded dividends in relation to avoidance of foetal malformation. However, it also resulted in reduced odds of seizure freedom during pregnancy which bordered on statistical significance particularly among women with generalised epilepsies.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110441"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizure-relapse risk following antiseizure medication withdrawal in children with non-lesional focal epilepsy","authors":"Hideaki Kanemura ,&nbsp;Yoshihiro Miyasato ,&nbsp;Yutaro Tomi ,&nbsp;Fumikazu Sano","doi":"10.1016/j.yebeh.2025.110439","DOIUrl":"10.1016/j.yebeh.2025.110439","url":null,"abstract":"<div><h3>Aims</h3><div>We investigated seizure-relapse risk following antiseizure medication (ASM) withdrawal in children with focal epilepsy (FE) who were leading to seizure remission by ASM monotherapy without drug replacement.</div></div><div><h3>Methods</h3><div>Participants were treated at our hospital between 1 July 1999 and 30 June 2015. Children showing abnormalities on brain MRI and self-limited FE were excluded. All children discontinued ASMs after more than 2 years of a seizure-free state. Associations between seizure relapse within 2 years following ASM withdrawal and age at onset, seizure-free interval before ASM withdrawal, duration of tapering, presence of interictal epileptiform discharges (IEDs) on electroencephalogram (EEG), and type of ASM used were evaluated.</div></div><div><h3>Results</h3><div>Participants comprised 128 FE children. Twelve children (9.7 %) experienced seizure relapse. Ages at both onset and ASM withdrawal were significantly higher in the relapse group than in the non-relapse group (p &lt; 0.0001 and p = 0.0003, respectively). Seizure-free interval before ASM withdrawal was significantly shorter in the relapse (mean, 2.6 years) than in the non-relapse group (3.6 years; p &lt; 0.0001). Duration of tapering was significantly shorter in the relapse (mean, 5.3 months) than in the non-relapse group (9.2 months; p &lt; 0.0001). Presence of IEDs was significantly more frequent in the relapse than in the non-relapse group (p = 0.03). Seizure relapse tended to be less frequent with levetiracetam treatment than with carbamazepine, but the difference was not significant (p = 0.067).</div></div><div><h3>Conclusions</h3><div>Among FE children who achieve a seizure-free state on ASMs for more than 3 years, clinicians should recommend withdrawal of ASM using a slow tapering schedules lasting more than 6 months.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"169 ","pages":"Article 110439"},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}