Epilepsy & Behavior最新文献

{"title":"The lived experience of the burden of normality: Explored through the lens of art therapy","authors":"Sarah Brown ,&nbsp;Honor Coleman ,&nbsp;Tammy Shella ,&nbsp;Sarah J Wilson","doi":"10.1016/j.yebeh.2025.110297","DOIUrl":"10.1016/j.yebeh.2025.110297","url":null,"abstract":"<div><div>Within the clinical and research spheres, there is increasing recognition of the importance of understanding the lived experience of ongoing illness and incorporating this voice into research and clinical practice. The current paper provides insights into the lived experience of undergoing epilepsy surgery, explored through the lens of art therapy. Six pieces of self-portraiture are presented that highlight key features of the burden of normality as experienced by joint first author Sarah Brown (SB) after her epilepsy surgery. Self-reflections from SB about her artwork are integrated with findings from the empirical literature that detail experiences of post-operative adjustment, providing novel insights into the post-operative adjustment process from the lived experience perspective. This approach highlights ways in which key findings from the research literature, which summates experiences at the group level, can be applied to the individual situation. The study also underscores the potential value of art therapy as a complementary therapy for holistic post-operative rehabilitation practices.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110297"},"PeriodicalIF":2.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurofilament light chain and glial fibrillary acidic protein as diagnostic and prognostic biomarkers in epileptic seizures and epilepsy: A systematic review","authors":"Annemarie Thaele ,&nbsp;Lorenzo Barba ,&nbsp;Samir Abu-Rumeileh ,&nbsp;Matteo Foschi ,&nbsp;Markus Otto","doi":"10.1016/j.yebeh.2025.110321","DOIUrl":"10.1016/j.yebeh.2025.110321","url":null,"abstract":"<div><div>Epileptology − with epilepsy as one of the most common neurological diseases − has an urgent need for easily accessible biomarkers to improve diagnosis, prognosis and therapeutic monitoring. Neurofilament light chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) have emerged as promising fluid biomarkers in various neurological disorders. Their potential role in epileptic seizures and epilepsy remains largely unexplored. To assess the current state of research on this topic we comprehensively searched the published literature for studies on GFAP and/or NfL in cerebrospinal fluid and/or blood in adult humans with epileptic seizures, status epilepticus or epilepsy (last data base search on 10th of May 2024). We identified a total of 2285 publications of which 19 fulfilled our search criteria. The studies targeted various outcomes such as prognosis in status epilepticus, differentiation of seizure semiology and etiology, differentiation of epileptic seizures from non-epileptic conditions, prediction of epilepsy in autoimmune epilepsy, after a stroke or after a first unprovoked seizure, the role of the time interval from seizure to sampling, the association with disease duration as well as seizure frequency and the influence of seizure suppressing medication. The results are heterogeneous but indicate promising applications for both NfL and GFAP in diagnosis and prognostication of patients with epileptic seizures and epilepsy.</div><div>In the present review we summarize the current evidence, future perspectives, but also limitations, of NfL and GFAP as fluid biomarkers in epilepsy and epileptic seizures.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110321"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes towards epilepsy in the Austrian general population: Predictors and national trends","authors":"Clemens Lang ,&nbsp;Ekaterina Pataraia ,&nbsp;Edda Haberlandt ,&nbsp;Michael Feichtinger ,&nbsp;Silvia Bonelli ,&nbsp;Gudrun Gröppel ,&nbsp;Moritz Feigl ,&nbsp;Eugen Trinka ,&nbsp;Christoph Baumgartner","doi":"10.1016/j.yebeh.2025.110291","DOIUrl":"10.1016/j.yebeh.2025.110291","url":null,"abstract":"<div><div>We aimed to assess attitudes towards epilepsy and people with epilepsy (PWE) in Austria using a web-based survey including demographics, the Caveness questionnaire (CQ) and Scales of Attitudes toward People with Epilepsy questionnaire (SAPE). Furthermore, we compared our results with a previous Austrian study and investigated predictors for negative attitudes towards epilepsy and PWE.</div><div>Results from 1017 adult respondents familiar with epilepsy revealed that 66.8% had had personal contact with PWE and 51.1% had experienced an epileptic seizure firsthand. However, only 28.3% of respondents were able to identify half of the correct answers regarding epilepsy as a disease and treatment options. This is highly important, as these were the strongest predictors for more positive attitudes towards PWE. In SAPE, another strong predictor for more favorable attitudes was prior personal contact with PWE. Compared to 2005, familiarity with epilepsy, personal contact with PWE as well as firsthand experience of seizures, and support for employing PWE like others increased significantly. While we report a favorable slight decrease of respondents who consider epilepsy a form of insanity, there was no significant difference in objection of their children having contact with children with epilepsy and marriage of their children with PWE.</div><div>Thus, we demonstrate that even though familiarity with epilepsy and personal contact with PWE increased in Austria, there are still negative attitudes towards epilepsy and PWE present. Further education campaigns should focus especially on the areas of epilepsy knowledge, epilepsy treatment and what to do when someone has an epileptic seizure.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110291"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical versus medical treatment of drug resistant epilepsy in children: Seizure and non-seizure outcomes","authors":"M.Scott Perry ,&nbsp;Dax Bourcier ,&nbsp;Paula Brna","doi":"10.1016/j.yebeh.2025.110269","DOIUrl":"10.1016/j.yebeh.2025.110269","url":null,"abstract":"<div><div>The goal of epilepsy treatment is to achieve the most significant seizure reduction, aiming for seizure freedom, in the absence of consequential adverse effects. For children with drug resistant epilepsy (DRE), surgical therapy may offer the best chance of seizure freedom, but is vastly underutilized. In cases where seizure freedom is not possible, surgery may still provide meaningful seizure reduction over that expected from continued medical management. In addition, seizure freedom and reduction can have meaningful impact on non-seizure outcomes including mortality, cognition, behavior, and cost of care. It is essential to compare the relative risks and benefits of continued medical therapy versus surgical therapy in order to best inform choice of treatment in pediatric DRE and avoid unnecessary delays. In this review, we explore the seizure and non-seizure benefits of epilepsy surgery, including curative procedures and those expected to result in meaningful seizure reduction, compared to continued medical management in children.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110269"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating manual preprocessing with automated feature extraction for improved rodent seizure classification","authors":"An Yu ,&nbsp;Mannut Singh ,&nbsp;Abhineet Pandey ,&nbsp;Elizabeth Dybas ,&nbsp;Aditya Agarwal ,&nbsp;Yifan Kao ,&nbsp;Guangliang Zhao ,&nbsp;Tzu-Jen Kao ,&nbsp;Xin Li ,&nbsp;Damian S. Shin ,&nbsp;Ming-Ching Chang","doi":"10.1016/j.yebeh.2025.110306","DOIUrl":"10.1016/j.yebeh.2025.110306","url":null,"abstract":"<div><h3>Hypothesis/Objective</h3><div>Rodent models of epilepsy can help with the search for more effective drug candidates or neuromodulatory therapies. Yet, preclinical screening of candidate options for anti-epileptic drugs (AED) using rodent models may require hours of video monitoring. Data processing is also time-consuming, subjective, and error-prone. This study aims to develop an AI-enabled quantitative analysis of rodent behavior, including epilepsy stage classification.</div></div><div><h3>Approach/Method</h3><div>We leveraged deep learning and computer vision techniques to develop a semi-automatic pipeline and framework for animal seizure detection and recognition, which requires manual preprocessing of the dataset. Our hybrid approach combines model-based and data-driven methods but is dependent on manually preprocessed and segmented video clips to facilitate the automatic classification of epilepsy stages.</div></div><div><h3>Results</h3><div>We collected two datasets comprising rat skeleton keypoints and seizure behavior videos in the lab. The proposed method, PoseC3D, for rat seizure stage classification of the collected database achieved an accuracy between 64.7–90.3 % when tested on four different seizure phenotypes using the Racine classification scale.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the feasibility of video-based seizure stage detection and classification for rodent models of temporal lobe seizures using a semi-automatic pipeline that requires manual preprocessing of data. However, our method is not capable of fully automated seizure detection and has not been tested on unseen animals, which limits its generalizability and applicability for broader use. Despite these limitations, the approach underscores our ability to undertake quantitative analysis of rodent behavior, which can also support other studies of animal behavior involving motor functions and future considerations for non-motor symptomology such as mood disorders.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110306"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the interval between the first unprovoked seizure and EEG influence the diagnostic yield?","authors":"Vaidehi Naganur ,&nbsp;Jacqueline Tse ,&nbsp;Jayan Muthusamy ,&nbsp;Shakira Snell ,&nbsp;Shuyu Wang ,&nbsp;Udaya Seneviratne","doi":"10.1016/j.yebeh.2025.110311","DOIUrl":"10.1016/j.yebeh.2025.110311","url":null,"abstract":"<div><h3>Objective</h3><div>There is no consensus on the optimum time for an EEG after the first seizure. We sought to investigate whether the timing of an EEG after a first unprovoked seizure influences its diagnostic yield.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted at a tertiary hospital in Australia. Adult patients who presented with a first unprovoked seizure were studied. Using multivariable logistic regression, we investigated the association of EEG timing, seizure presentation, and risk factors for epilepsy with the presence of interictal epileptiform discharges (IED) in the EEG as the outcome. The chi-square test compared EEG yields across each week after the seizure.</div></div><div><h3>Results</h3><div>Among 452 patients, the time from seizure to EEG did not show a statistically significant impact on the presence of IEDs (OR = 1, 95 % CI 0.99–1, p = 0.095). The yield of epileptiform abnormalities generally declined over time but was not statistically significant across weeks (p = 0.40). A modest but significant relationship was found between age and the likelihood of detecting IEDs, with older age associated with a lower yield of abnormalities (OR = 0.98, 95 % CI 0.973–0.997, p = 0.016).</div></div><div><h3>Conclusion</h3><div>Our results suggest that the timing of the EEG following the first unprovoked seizure does not significantly impact the diagnostic yield.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110311"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratifying cognitive and behavioral comorbidities in children with new-onset seizures – The influence of sociodemographic disadvantage","authors":"Karina Morales ,&nbsp;Tracy De Los Santos ,&nbsp;Danielle Harvey ,&nbsp;David Dunn ,&nbsp;Jana Jones ,&nbsp;Anna Byars ,&nbsp;Joan Austin ,&nbsp;Bruce Hermann ,&nbsp;Temitayo Oyegbile-Chidi","doi":"10.1016/j.yebeh.2025.110267","DOIUrl":"10.1016/j.yebeh.2025.110267","url":null,"abstract":"<div><h3>Rationale</h3><div>Children with new-onset epilepsy often experience co-morbid cognitive and behavioral challenges, which can be influenced by Social Determinants Of Health (SDOH) such as household income and parental education level. Although unsupervised machine learning has identified distinct cognitive and behavioral phenotypes at or near diagnosis, the relationship between these clusters remains underexplored. This study aims to examine the relationship between cognitive and behavioral clusters and the impact of SDOH among children with new-onset seizures.</div></div><div><h3>Methods</h3><div>We recruited 312 children (ages 6–16) within six weeks of their first recognized seizure. Each participant underwent a comprehensive neuropsychological assessment, from which factor analysis identified four primary domains: language, processing speed, executive function, and verbal memory. Parents also completed the Child’s Behavior Checklist (CBCL). K-means cluster analysis was applied to the mean factor scores and CBCL T-scores to identify unique clusters. We assessed SDOH factors, including maternal education level, child’s race, household income, and parental marital status, along with clinical epilepsy characteristics such as age at seizure onset, seizure frequency/intensity, seizure syndrome, MRI/EEG abnormalities, and neurologic examination findings to distinguish these clusters.</div></div><div><h3>Results</h3><div>We identified two primary clusters within both cognitive and behavioral scores: Resilient and At-Risk. Children in the Resilient Cognitive Cluster exhibited fewer behavioral problems, while those in the Resilient Behavior Cluster demonstrated higher cognitive performance. Conversely, the At-Risk Cognitive Cluster was associated with greater behavioral problems, and the At-Risk Behavior Cluster correlated with lower cognitive performance. Notably, almost two-thirds of participants showed congruence in clustering, either displaying resilience in both cognition and behavior or vulnerability in both domains. Resilient children exhibited lower levels of sociodemographic disadvantage, whereas those in the At-Risk Clusters faced significant disadvantages. Sociodemographic factors were more pronounced in differentiating clusters compared to traditional clinical epilepsy characteristics.</div></div><div><h3>Conclusions</h3><div>Among children with new-onset seizures, some display significant resilience to multimorbidities, while others are particularly vulnerable to neurobehavioral challenges, often linked to sociodemographic disadvantages. Future research should explore whether early interventions targeting SDOH can mitigate these risks and improve outcomes for children with new-onset epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110267"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticipatory guidance and care in pediatric and adult neurology for people with epilepsy who became pregnant","authors":"Amy K. Tao ,&nbsp;Jasmin Rivero-Guerra ,&nbsp;Katherine N. McFarlane ,&nbsp;Wesley T. Kerr ,&nbsp;Page B. Pennell ,&nbsp;Judy C. Chang ,&nbsp;Traci M. Kazmerski ,&nbsp;Elizabeth I. Harrison ,&nbsp;Laura Kirkpatrick","doi":"10.1016/j.yebeh.2025.110292","DOIUrl":"10.1016/j.yebeh.2025.110292","url":null,"abstract":"<div><h3>Objective</h3><div>To assess documentation of pregnancy-related counseling and care for people with epilepsy of childbearing potential (PWECP) in pediatric and adult neurology who became pregnant.</div></div><div><h3>Methods</h3><div>We reviewed health records for primigravida PWECP prescribed an antiseizure medication (ASM) who delivered between June 2014 and May 2024 within one academic medical center. We used chi-squared tests to compare counseling, ASM prescriptions, and recommendations for supplemental folic acid between individuals in pediatric and adult neurology care before pregnancy. We performed logistic regression for these outcomes of pre-pregnancy counseling associated with type of neurology care, race, ethnicity, intellectual disability (ID), teratogenic profile of ASMs prescribed, and ASM polytherapy.</div></div><div><h3>Results</h3><div>173 PWECP (84 % White non-Hispanic, 9 % with intellectual disability (ID) were included. Twenty-one (12 %) transferred from pediatric to adult neurology care due to pregnancy (“pediatric group”) and 152 (88 %) were previously established with adult neurology (“adult group”). PWECP in the pediatric group compared to the adult group had lower rates of documentation of clinician discussion of ASM teratogenicity (43 % vs 66 %, p = 0.041) and folic acid use (24 % vs 63 %, p = 0.001) before pregnancy. PWECP established with adult neurology prior to pregnancy were significantly more likely to have been taking folic acid before pregnancy (OR 5.21, 95 % CI 1.78–15.3). Individuals with ID were significantly less likely to have documentation of discussion of ASM teratogenicity (OR 0.18, 95 % CI 0.05–0.62).</div></div><div><h3>Conclusion</h3><div>Our findings suggest a need for improvement in providing pre-pregnancy guidance and care for PWECP, especially for PWECP in pediatric neurology care and those with ID.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110292"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizures exacerbate depressive symptoms in persons with epilepsy","authors":"Maria Pleshkevich ,&nbsp;Amit Ahituv ,&nbsp;Eden Tefera ,&nbsp;Anureet Kaur ,&nbsp;Dan V. Iosifescu ,&nbsp;Claude Steriade","doi":"10.1016/j.yebeh.2025.110304","DOIUrl":"10.1016/j.yebeh.2025.110304","url":null,"abstract":"<div><div>The mechanisms behind comorbid symptoms of depression in persons with epilepsy (PWE) remain largely unknown. Our study aimed to learn whether seizures moderate fluctuations in depressive symptoms in PWE when controlling for preictal symptoms of depression. We enrolled 57 adult PWE admitted to the New York University (NYU) Langone Epilepsy Monitoring Unit (EMU) from 2021 to 2024. Thirty-seven participants had a seizure. Twenty of the admitted patients did not have seizures during the admission period and therefore served as controls. All participants were seizure free for &gt; 7 days prior to participation. Upon admission, all participants completed the Montgomery-Asberg Depression Rating Scale (MADRS) to evaluate baseline mood. The MADRS was repeated acutely (4–24 h post seizure or admission) and subacutely (2–7 days post seizure or discharge) for both groups. Linear regression models revealed that individuals with higher baseline MADRS scores (indicating higher depressive symptoms) experienced worse mood acutely post-seizure, while lower baseline MADRS scores were associated with acute mood improvement (<em>R</em>² = 0.59, <em>p</em> &lt; 0.001). Experiencing a seizure was not associated with subacute mood outcomes, which were instead driven by acute mood state (<em>R</em>² = 0.56, <em>p</em> &lt; 0.001). In conclusion, we found that seizures exacerbate pre-ictal depressive symptoms and that post-ictal depressive symptoms persist up to 7 days after seizure resolution. This study may provide evidence for a bidirectional relationship and demonstrate a vicious cycle between depression and epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110304"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative EEG biomarkers of cognitive performance in drug-resistant temporal lobe epilepsy","authors":"Sofía Lallana ,&nbsp;Samuel López-Maza ,&nbsp;Gemma Ortega ,&nbsp;Elena Fonseca ,&nbsp;Manuel Quintana ,&nbsp;Laura Abraira ,&nbsp;Enric Bellido ,&nbsp;Daniel Campos-Fernández ,&nbsp;Estevo Santamarina ,&nbsp;Agustín Ruiz ,&nbsp;Lluís Tárraga ,&nbsp;Mercè Boada ,&nbsp;Manuel Toledo","doi":"10.1016/j.yebeh.2025.110323","DOIUrl":"10.1016/j.yebeh.2025.110323","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to explore quantitative electroencephalography (qEEG) biomarkers of cognitive performance in drug-resistant temporal lobe epilepsy (TLE) and analyze their relationship with clinical characteristics.</div></div><div><h3>Methods</h3><div>Cross-sectional study including adult patients with drug-resistant TLE and a control group. Resting-state, eyes-closed qEEG samples were analyzed using the fast Fourier transform approach. Power spectral density was calculated for four frequency bands: delta (1–3.9 Hz), theta (4–7.9 Hz), alpha (8–12.9 Hz), and beta (13–18 Hz). Neuropsychological tests were administered to TLE patients.</div></div><div><h3>Results</h3><div>Twenty-nine TLE patients (mean age 42 ± 8.2 years; 44.8 % women) and 23 age- and sex-matched controls were enrolled. Clinically significant cognitive impairment was found in 86.2 % of patients (58.6 % amnestic). Compared to controls, TLE patients showed increased ipsilateral power spectral density for the theta (p = 0.045), alpha (p = 0.023) and beta bands in the anterior region (p = 0.029) and for the delta band in the posterior region (p = 0.03). Alpha/theta ratio (ATR) was lower in the posterior quadrant of the epileptogenic hemisphere (p = 0.013), and higher seizure frequency correlated with a lower ATR in the ipsilateral temporal region (r: −0.425; p = 0.021). Patients with amnestic cognitive impairment exhibited higher power spectral density across most frequency bands (p &lt; 0.005). Impaired verbal memory and executive function were associated with increased power density.</div></div><div><h3>Conclusion</h3><div>Increased power spectral density was evident in all frequency bands in the epileptogenic hemisphere, particularly in those patients with amnestic cognitive impairment. Moreover, higher seizure frequency correlated with a lower ATR in the temporal region. Power spectral analysis can provide useful information in drug-resistant TLE patients.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110323"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}