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IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-02-20 DOI:10.1016/j.yebeh.2025.110323

Sofía Lallana , Samuel López-Maza , Gemma Ortega , Elena Fonseca , Manuel Quintana , Laura Abraira , Enric Bellido , Daniel Campos-Fernández , Estevo Santamarina , Agustín Ruiz , Lluís Tárraga , Mercè Boada , Manuel Toledo

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引用次数: 0

摘要

背景本研究旨在探索耐药性颞叶癫痫（TLE）认知表现的定量脑电图（qEEG）生物标志物，并分析其与临床特征的关系。采用快速傅立叶变换法分析静息态、闭眼qEEG样本。计算了四个频段的功率谱密度：delta（1-3.9 Hz）、theta（4-7.9 Hz）、alpha（8-12.9 Hz）和 beta（13-18 Hz）。结果29名TLE患者（平均年龄42±8.2岁；44.8%为女性）和23名年龄和性别匹配的对照组患者被纳入研究。86.2%的患者（58.6%为失忆症患者）出现了明显的临床认知障碍。与对照组相比，TLE 患者前部区域的θ波段（p = 0.045）、α波段（p = 0.023）和β波段（p = 0.029）以及后部区域的δ波段（p = 0.03）的同侧功率谱密度均有所增加。致痫半球后象限的α/θ比值（ATR）较低（p = 0.013），癫痫发作频率较高与同侧颞区的ATR较低相关（r：-0.425；p = 0.021）。失忆性认知障碍患者在大多数频带上表现出更高的功率谱密度（p < 0.005）。结论致痫半球所有频段的功率谱密度均明显增加，尤其是在有失忆性认知障碍的患者中。此外，癫痫发作频率越高，颞区的 ATR 越低。功率谱分析可为耐药性TLE患者提供有用的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Quantitative EEG biomarkers of cognitive performance in drug-resistant temporal lobe epilepsy

Background

This study aimed to explore quantitative electroencephalography (qEEG) biomarkers of cognitive performance in drug-resistant temporal lobe epilepsy (TLE) and analyze their relationship with clinical characteristics.

Methods

Cross-sectional study including adult patients with drug-resistant TLE and a control group. Resting-state, eyes-closed qEEG samples were analyzed using the fast Fourier transform approach. Power spectral density was calculated for four frequency bands: delta (1–3.9 Hz), theta (4–7.9 Hz), alpha (8–12.9 Hz), and beta (13–18 Hz). Neuropsychological tests were administered to TLE patients.

Results

Twenty-nine TLE patients (mean age 42 ± 8.2 years; 44.8 % women) and 23 age- and sex-matched controls were enrolled. Clinically significant cognitive impairment was found in 86.2 % of patients (58.6 % amnestic). Compared to controls, TLE patients showed increased ipsilateral power spectral density for the theta (p = 0.045), alpha (p = 0.023) and beta bands in the anterior region (p = 0.029) and for the delta band in the posterior region (p = 0.03). Alpha/theta ratio (ATR) was lower in the posterior quadrant of the epileptogenic hemisphere (p = 0.013), and higher seizure frequency correlated with a lower ATR in the ipsilateral temporal region (r: −0.425; p = 0.021). Patients with amnestic cognitive impairment exhibited higher power spectral density across most frequency bands (p < 0.005). Impaired verbal memory and executive function were associated with increased power density.

Conclusion

Increased power spectral density was evident in all frequency bands in the epileptogenic hemisphere, particularly in those patients with amnestic cognitive impairment. Moreover, higher seizure frequency correlated with a lower ATR in the temporal region. Power spectral analysis can provide useful information in drug-resistant TLE patients.

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.