Meteorological influences on seizure occurrence in children with epilepsy: a case-crossover analysis

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-08-27 DOI:10.1016/j.yebeh.2025.110667

Yuto Arai , Tohru Okanishi , Hisashi Noma , Hiroshi Sunada , Sotaro Kanai , Masami Togawa , Takako Ohno , Toshiaki Tanaka , Hiroyuki Yamada , Masanori Maeda , Takeshi Matsushige , Yoshihiro Maegaki

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引用次数: 0

Abstract

Purpose

Research on the association between meteorological conditions and epileptic seizures in children with epilepsy (CWE) remains limited. This study aimed to evaluate the effects of atmospheric pressure, temperature, and humidity on seizure occurrence in CWE.

Methods

We conducted a multicenter prospective observational study involving CWE under 16 years of age who had experienced seizures more than once per year but less than once per week over the past year. Participants were enrolled between November 1, 2022, and December 31, 2023. For one year following enrollment, meteorological data were recorded at the time of each seizure (T0) and at 6, 12, 24, and 48 h prior to T0. Control data were collected from one (T1) and two (T2) days before T0. Conditional logistic regression was used to assess associations, adjusting for common-cold symptoms, sleep duration, menstruation, missed medication, age, and sex.

Results

A total of 159 seizures (median: three per participant per year) occurred in 29 children. Higher maximum relative humidity within 12 and 24 h prior to T0, compared to the same intervals prior to T2, was significantly associated with increased seizure risk (12 h: odds ratio [OR], 1.026; 95 % confidence interval [CI], 1.003–1.048; p = 0.023; 24 h: OR 1.033; 95 % CI, 1.004–1.063; p = 0.025). No significant associations were found for other meteorological variables.

Conclusion

Elevated maximum humidity 12–24 h prior to seizure onset may increase seizure risk in CWE.

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气象因素对儿童癫痫发作的影响：病例交叉分析

目的对气象条件与癫痫儿童发作之间关系的研究仍然有限。本研究旨在评估大气压、温度和湿度对CWE癫痫发作的影响。方法：我们进行了一项多中心前瞻性观察研究，涉及16岁以下的CWE，这些CWE在过去一年中每年发作一次以上，但每周少于一次。参与者在2022年11月1日至2023年12月31日期间注册。在入组后的一年中，记录每次癫痫发作时（T0）以及T0前6、12、24和48小时的气象数据。对照数据于T0前1天（T1）和2天（T2）采集。使用条件逻辑回归来评估相关性，调整普通感冒症状、睡眠时间、月经、未服药、年龄和性别。结果29名儿童共发生159次癫痫发作（中位数：每位参与者每年3次）。与T2前相同时间间隔相比，T0前12和24小时内较高的最大相对湿度与癫痫发作风险增加显著相关（12小时：优势比[OR]， 1.026； 95%可信区间[CI]， 1.003-1.048; p = 0.023； 24小时：OR 1.033; 95% CI, 1.004-1.063; p = 0.025）。其他气象变量没有发现显著的关联。结论癫痫发作前12 ~ 24 h最大湿度升高可增加CWE患者癫痫发作风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.