European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Efficacy of racemic ketamine or esketamine monotherapy for reducing suicidal ideation in uni- or bipolar depression: a systematic review and meta-analysis.","authors":"Jiafeng Li, Ling Ma, Huan Sun, Meng Li, Yuan Cao, Yang Peng, Jiajun Xu","doi":"10.1007/s00406-024-01920-x","DOIUrl":"10.1007/s00406-024-01920-x","url":null,"abstract":"<p><p>The current systematic review and meta-analysis examined the effect of racemic ketamine or esketamine on suicidal ideation in individuals with uni- or bipolar depression. We searched the MEDLINE, Embase, Central, PsycINFO, and Web of Science databases to identify randomized controlled trials that examined the effect of racemic ketamine or esketamine monotherapy on suicidal ideation (SI) in individuals with uni- or bipolar depression. The two monotherapies were compared; the primary outcome was the rate of remission of SI, and the secondary outcome was the SI score. The risk ratio was used as an effect size measure for binary variables, while the standardized mean difference was used as an effect size measure for continuous variables. Our meta-analysis included 13 randomized controlled trials involving 1,1109 individuals with uni- or bipolar depression. Patients receiving racemic ketamine monotherapy had a significantly higher acute SI remission rate than those receiving placebo or midazolam (RR = 2.06, 95% CI 1.47 to 2.91, P < 0.0001). Racemic ketamine also led to significantly lower SI scores than placebo or midazolam (SMD = -0.36, 95% CI -0.71 to -0.01, P = 0.04). The evidence for the treatment of SI with esketamine was inconsistent. The pooled effect sizes for long-term anti-SI effects did not reveal significant differences between therapies. Our study indicated the efficacy of racemic ketamine monotherapy for rapidly and transiently reducing SI in individuals with uni- or bipolar depression, but the efficacy of racemic ketamine monotherapy against long-term suicidal ideation remains unclear. There is not -sufficient evidence to support the anti-suicidal effects of esketamine monotherapy.Protocol registration: Prospero registration number: CRD42023434380.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1359-1371"},"PeriodicalIF":3.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative pharmacological depression treatment.","authors":"Hans-Jürgen Möller, Rainer Rupprecht, Andreas Reif","doi":"10.1007/s00406-025-02040-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02040-w","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment decision making in patients with bipolar and schizophrenia spectrum disorders: a comparison.","authors":"Laura Iozzino, Donato Martella, Marco Picchioni, Johannes Wancata, Paul S Appelbaum, Gabriele Mandarelli, Felice Carabellese, Roberto Catanesi, Lia Parente, Fulvio Carabellese, Stefano Ferracuti, Giovanni de Girolamo","doi":"10.1007/s00406-025-02063-3","DOIUrl":"https://doi.org/10.1007/s00406-025-02063-3","url":null,"abstract":"<p><p>This study investigates the decision-making capacities of patients with bipolar disorder (BD) and schizophrenia spectrum disorders (SSD), focusing on differences across four dimensions assessed by the MacArthur Competence Assessment Tool for Treatment (MacCAT-T): Understanding, Appreciation, Reasoning, and Expressing a Choice. A total of 398 patients (237 SSD and 161 BD) were included, with data collected from both inpatient and outpatient settings. Patients with SSD exhibited greater psychopathological severity, were predominantly male, and had a lower level of education compared to BD patients. No significant differences were found between groups in Understanding, Reasoning, or Choice dimensions of the MacCAT-T. However, BD patients scored higher in the Appreciation domain, indicating a better ability to recognize the relevance of medical information to their personal circumstances. Psychopathological severity, measured by the Brief Psychiatric Rating Scale (BPRS) and Positive and Negative Syndrome Scale (PANSS), significantly influenced MacCAT-T scores. In SSD patients, conceptual disorganization and lack of judgment negatively impacted decision-making, while BD patients were adversely affected by somatic concerns and hostility. Cognitive impairments, particularly in SSD, appeared to contribute to differences in the Appreciation domain. The study highlights the influence of psychopathology on decisional capacity in severe mental illness, with implications for tailored clinical interventions. Despite similar overall capacity levels between groups, further research is needed to explore the role of cognitive and contextual factors in shaping these abilities. These findings support the use of standardized tools to guide clinical assessments and ensure informed decision-making in psychiatric care.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative emotions weaken the error monitoring ability of patients with borderline personality disorder.","authors":"Huihui Yang, Wanrong Peng, Zhaoxia Liu, Suyao Liu, Kaili Zheng, Ming Cheng, Jinyao Yi","doi":"10.1007/s00406-025-02072-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02072-2","url":null,"abstract":"<p><p>Patients with Borderline Personality Disorder (BPD) exhibit impaired inhibitory control and heightened affective sensitivity. This study aimed to investigate how negative emotions influence error monitoring in BPD. Twenty-six BPD patients and twenty-eight health controls completed psychological scales assessing borderline symptoms, impulsivity, depression and anxiety. Subsequently, participants performed an emotional stop signal task while electroencephalogram (EEG) data were collected. Error-related neural activity was analyzed, focusing on the amplitude of error-related negativity (ERN), error positivity (Pe), and power values of error-related θ. Repeated measures analysis of variance (ANOVA) assessed differences by group and emotion type. Pearson correlations were calculated between error-related EEG variables and psychological scales. Results revealed significant group-by-emotion type interactions for ERN amplitude (F = 27.094, p < 0.001, η²_p = 0.387) and θ power (F = 4.121, p = 0.049, η²_p = 0.093). Specifically, under negative emotional conditions, BPD patients exhibited significantly lower ERN amplitudes and θ power than controls, while no significant group differences were found under neutral conditions. ERN amplitude at FZ under negative emotion conditions correlated significantly with non-planning impulsivity (r = 0.466). Moreover, θ power under neutral conditions correlated significantly with borderline symptoms and impulsive behaviors (r = 0.447 to 0.612). In conclusion, BPD patients demonstrate notable deficits in error detection during negative emotion states, impairing their ability to correct errors and adjust behaviors. The results provide valuable insights for clinical intervention of impulsive behaviors in BPD, as such behaviors can be reduced by guiding patients to attend to the consequences of impulsive behaviors in negative emotional states.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigation of self-inflicted versus other-inflicted injury behaviour in individuals with borderline personality disorder.","authors":"Anna Görtz, Ardita Sulejmani, Nikolaus Kleindienst, Christian Schmahl, Marius Schmitz, Rolf-Detlef Treede, Ulf Baumgärtner","doi":"10.1007/s00406-025-02059-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02059-z","url":null,"abstract":"<p><strong>Introduction: </strong>Non-suicidal self-injury (NSSI) is found in over 70% of patients with Borderline Personality Disorder (BPD). The most common method is cutting, which is often used to reduce high levels of aversive tension under stress. Recent studies have shown that pain during injury is a major factor reducing this stress. This report focuses on the question, whether the stress relieving effect of a sharp pain stimulus is different, when the patient herself is inflicting the stimulus on the forearm.</p><p><strong>Methods: </strong>86 patients with BPD participated in this study. Stress was induced with a personalized script, followed by a non-invasive pain stimulus with a blunt blade, either self-inflicted or inflicted by the experimenter. Subjective (arousal, urge for NSSI, pain intensity) and objective (heart rate) parameters were measured to evaluate stress and pain. Group differences were analysed using hierarchical linear modelling.</p><p><strong>Results: </strong>Pain intensity, arousal and the urge for NSSI were similar under both conditions. The initial decrease in heart rate following the pain stimulus was significantly larger when the stimulus was applied by the experimenter and was delayed by a few minutes in the self-inflicted condition.</p><p><strong>Conclusions: </strong>In this experimental setting, the perspective of pain application (self vs. other) had no differential influence on either NSSI, pain intensity, or stress level. The stronger initial decrease in heart rate in the other-inflicted group during the stimulus may be due to the lack of active physical involvement in the procedure, which could have delayed the decrease of heart rate in the self-inflicted group.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic predisposition to unwanted side effects under antidepressants and antipsychotics: a molecular-genetic study of 902 patients over 6 weeks.","authors":"Hans H Stassen, S Bachmann, R Bridler, K Cattapan, A M Hartmann, D Rujescu, E Seifritz","doi":"10.1007/s00406-025-02062-4","DOIUrl":"https://doi.org/10.1007/s00406-025-02062-4","url":null,"abstract":"<p><p>This project aimed at (1) detailing the complex side effect patterns of 902 inpatients treated for major depression or schizophrenia under polypharmacy regimens; (2) developing a quantitative side effect model that accounts for the various facets of clinically observable adverse events; and (3) analyzing irregularities in genetic diversity through multidimensional \"gene vectors\" in order to reveal possible interrelations with side effect clusters. The patients' acute medication, their time course of recovery, and their side effects were assessed by up to 8 repeated measurements. The genotyping included 100 candidate genes with genotypic patterns computed from 549 Single Nucleotide Polymorphisms (SNPs). Between 61.9% and 68.1% of study patients reported moderate to severe side effects, while response rates were with 29.5-35.7% quite modest. Half of the patients (52.1%) experienced weight gains of ≥ 2 kg. On the phenotype level, up to 30% of the observed variance could be \"explained\" by regression models with the dominating factor \"number of concurrent drugs\". On the genotype level, we relied on standard Artificial Intelligence (AI) procedures along with multilayer Neural Nets (NNs) to search for combinations of multidimensional genotypic patterns that were characteristic of patients with severe side effects, while being rare (< 10%) among patients without side effects. These analyses failed to explain a clinically relevant proportion of the observed phenotypic variance. The 14 cytochromes analyzed were found to play no more than a minor role. While type and severity of side effects under polypharmacy were primarily determined by the overall medication \"load\", the actually observed side effect patterns varied considerably between patients receiving the same medication \"load\", thus stressing the role of genetics. Our results suggested that the role of genetics in the development of severe side effects under polypharmacy is by far more complex than previously assumed, related to a completely different set of genes, or that there exists genotypic heterogeneity such that multiple pathways on the genotype level lead to the same clinical picture on the phenotype level.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep traits and physical activity mediate the causal association between depression and age-related diseases.","authors":"Jin Wei, Meng Zhang, Mengmeng Qi, Chang He, Shiyin Ma, Liutao Sui, Zhi Mao, Xiaoyan Zhu, Xudong Pan","doi":"10.1007/s00406-025-02068-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02068-y","url":null,"abstract":"<p><strong>Background: </strong>A growing body of evidence suggests the relationship of depression with an increased risk of age-related diseases (ARDs). To further understand the genetically predicted causative connections, a Mendelian randomization (MR) approach was conducted.</p><p><strong>Methods: </strong>Genetic variants associated with depression were employed as instrumental variables from the PGC and FinnGen consortium, respectively. GWAS summary data for 14 ARDs were derived from recently large consortia. We employed univariable and bidirectional MR analysis, and meta-analysis combining the results from two databases. Importantly, the potential mediation effects and mediated proportions of sleep and exercise traits were evaluated using a two-step mediation MR analysis. Finally, the robustness of all the MR results was confirmed using multiple sensitivity analyses.</p><p><strong>Results: </strong>In univariable MR analysis, results of combine effect showed that genetically linked depression was causally associated with a range of ARDs, including myocardial infarction (MI) (OR: 1.156, 95%CI: 1.038-1.288, p = 0.008), coronary atherosclerosis (CAS) (OR: 1.008, 95%CI: 1.004-1.013, p < 0.001), peripheral arteriosclerotic disease (OR: 1.002, 95%CI: 1.000-1.003, p = 0.020), obesity (OR: 1.028, 95%CI: 1.001-1.056, p = 0.044), type 2 diabetes (T2D) (OR: 1.112, 95%CI: 1.034-1.197, p = 0.004), and metabolic syndrome (OR: 1.204, 95%CI: 1.064-1.364, p = 0.003). Reverse analyses revealed the causal effect of obesity on depression (OR: 1.110, 95%CI: 1.070-1.152, p < 0.001). In mediation analyses, physical activity and/or sleep traits mediated the causal associations between depression and MI, CAS, and T2D. We further quantified the mediation effects. Sensitivity analyses supported these observations.</p><p><strong>Conclusion: </strong>Depression is causally associated with MI, CAS, peripheral arteriosclerotic disease, obesity, T2D, and metabolic syndrome. Moreover, physical activity and sleep traits, either individually or in combination, appear to mediate the causal associations.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High dosage accelerated intermittent theta burst stimulation without precision targeting and dosing in depression: an open-label pilot study.","authors":"Miaoxi Chen, Jonas Björklund, Kai-Yen Chang, Gerrit Burkhardt, Lucia Bulubas, Simone Weller, Kristin Hagenah, Daniel Kesser, Andre R Brunoni, Frank Padberg, Ulrike Vogelmann","doi":"10.1007/s00406-025-02067-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02067-z","url":null,"abstract":"<p><strong>Background: </strong>High dosage accelerated intermittent theta-burst stimulation (aiTBS) protocols (10 sessions per day for 5 days) combined with precision targeting and depth adjusted iTBS intensity yield high response and remission rates in depression. However, disentangling their efficacy components to develop pragmatic mental health solutions is challenging. This pilot study applied such a high dosage aiTBS protocol without using any precision features.</p><p><strong>Methods: </strong>Eight patients with treatment-resistant depression (TRD) underwent open-label aiTBS targeting the left dorsolateral prefrontal cortex (DLPFC) using the Beam F3 algorithm. Over 5 days, patients received 50 aiTBS sessions, each delivering 1800 pulses at 90% resting motor threshold with 50-min inter-session intervals. All patients underwent a 4 weeks follow-up without stimulation, were offered tDCS for 4 weeks thereafter and had a final follow-up after 6 months. Treatment effects were assessed by clinical and cognitive measures.</p><p><strong>Results: </strong>Patients received 46 aiTBS sessions on average. At one-month follow-up, mean MADRS scores decreased by -12.50 ± 9.81 (Cohen's d = 2.83; 95% CI, 2.34-3.32; p < 0.001), with response and remission rates of 50% and 12.5%, respectively. After tDCS, 28.6% and 14.3% sustained response and remission, which declined to 16.7% and 0% at six months.</p><p><strong>Conclusion: </strong>This pilot trial evidenced the antidepressant effect of a high dosage aiTBS protocol comparable with the Stanford Neuromodulation Therapy (SNT) approach but without individualized precision components. Its effectiveness appeared lower than previously reported for SNT. Randomized controlled trials should systematically investigate the contribution of precision components to the overall effectiveness of aiTBS in depression. This trial is a part of a real-world clinical study of non-invasive brain stimulation treatments conducted at our department (preregistered at DRKS-ID: DRKS00024776, drks.de).</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathological, neuropsychological and sociodemographic description of the population using a post-COVID outpatient clinic: results from the 2Long4COVID BLOOD study.","authors":"Katharina Dünnwald, Yannik Adam, Donata von Freymann, Alexia Synetou, Stefan Kruse, Elisabeth Pracht, Dominic Rauschning, Clara Lehmann, Joseph Kambeitz, Theresa Katharina Lichtenstein","doi":"10.1007/s00406-025-02065-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02065-1","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of post-COVID syndrome (PCS) is estimated to be below 1%, with notable variation across different SARS-CoV-2 variants. The syndrome is characterized by a broad spectrum of clinical manifestations affecting multiple organ systems. Cognitive impairments and psychological distress are frequently observed; however, their underlying pathophysiological mechanisms remain poorly understood.</p><p><strong>Objective: </strong>This study examines the sociodemographic, psychopathological, and neuropsychological characteristics of patients treated at our psychiatric post-COVID outpatient clinic (PPCO-clinic).</p><p><strong>Method: </strong>Patients were recruited from the post-COVID outpatient clinic of the Department of Infectious Diseases at Cologne University Hospital. Assessments included observer-rated evaluations, neuropsychological testing, and psychopathological examinations. Data from 41 patients were analyzed and compared with normative data from healthy controls reported in the literature.</p><p><strong>Results: </strong>Between April and November 2022, 42 patients attended the PPCO-clinic, with 41 included in the analysis (58.5% female; mean age: 45 years). Patients exhibited significantly poorer performance across all neuropsychological tests compared to healthy controls, with pronounced deficits in visual memory, phonematic fluency, visuomotor function, and global cognitive screening. Additionally, they reported significantly higher levels of depression, anxiety, daytime sleepiness, fatigue, and reduced quality of life. Personality assessments revealed increased neuroticism and lower extraversion, conscientiousness, and agreeableness.</p><p><strong>Conclusion: </strong>These findings underscore the importance of comprehensive neuropsychological and psychopathological assessments in individuals with PCS-particularly in cases where symptoms persist beyond the scope of routine primary care-to ensure accurate evaluation and effective management.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postictal resting-state connectivity changes after electroconvulsive therapy-induced seizures.","authors":"Julia C M Pottkämper, Joey P A J Verdijk, Sven Stuiver, Freek Ten Doesschate, Michel J A M van Putten, Jeannette Hofmeijer, Jeroen A van Waarde, Guido A van Wingen","doi":"10.1007/s00406-025-02043-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02043-7","url":null,"abstract":"<p><p>Electroconvulsive therapy (ECT) leads to temporary changes of brain function. It is unclear what changes take place shortly after the induced seizures. Here, we present the first human study on resting-state network (RSN) changes in the immediate postictal state. The objective was to investigate brain-wide RSNs connectivity changes shortly after ECT-induced seizures. We analyzed prospectively collected resting-state functional magnetic resonance imaging scans from 17 patients with major depression at baseline and one hour after ECT-sessions. RSNs were extracted and changes in mean and voxel-wise RSN connectivity strength were calculated. Data were compared to 27 age, sex, and level of education matched healthy individuals to account for test-retest effects. Clinical postictal recovery was measured using the reorientation time questionnaire. Group by time interaction analyses showed postictal decreases in mean connectivity strength in the left central executive network and the auditory network in patients, compared to retest in healthy controls (β = - 0.18 [CrI95 - 0.27, - 0.09] and (β = - 0.22 [CrI95 - 0.36, - 0.07], respectively). Voxel-wise analyses revealed increased between-network connectivity in the salience network with cerebellar regions compared to healthy controls, along with decreased within-network connectivity in the default mode network and left central executive network. No significant associations with clinical recovery or other variables were observed. In this cohort, ECT-induced seizures were followed by postictal decreases of connectivity strength in the left central executive network and the auditory network and increase of connectivity between the salience network and cerebellum. Postictal network changes were not associated with clinical postictal recovery.Clinical trial registration: ClinicalTrials.gov NCT04028596.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}