European Archives of Psychiatry and Clinical Neuroscience最新文献_第8页

Exploring the correlation between childhood trauma experiences, inflammation, and brain activity in first-episode, drug-naive major depressive disorder. 探索首次发病、未服药的重度抑郁症患者的童年创伤经历、炎症和大脑活动之间的相关性。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-07-29 DOI: 10.1007/s00406-024-01847-3

Yuan Liu, Yifan Jing, Ying Gao, Meijuan Li, Wen Qin, Yingying Xie, Bin Zhang, Jie Li

{"title":"Exploring the correlation between childhood trauma experiences, inflammation, and brain activity in first-episode, drug-naive major depressive disorder.","authors":"Yuan Liu, Yifan Jing, Ying Gao, Meijuan Li, Wen Qin, Yingying Xie, Bin Zhang, Jie Li","doi":"10.1007/s00406-024-01847-3","DOIUrl":"10.1007/s00406-024-01847-3","url":null,"abstract":"Background: Childhood trauma experiences and inflammation are pivotal factors in the onset and perpetuation of major depressive disorder (MDD). However, research on brain mechanisms linking childhood trauma experiences and inflammation to depression remains insufficient and inconclusive.Methods: Resting-state fMRI scans were performed on fifty-six first-episode, drug-naive MDD patients and sixty healthy controls (HCs). A whole-brain functional network was constructed by thresholding 246 brain regions, and connectivity and network properties were calculated. Plasma interleukin-6 (IL-6) levels were assessed using enzyme-linked immunosorbent assays in MDD patients, and childhood trauma experiences were evaluated through the Childhood Trauma Questionnaire (CTQ).Results: Negative correlations were observed between CTQ total (r = -0.28, p = 0.047), emotional neglect (r = -0.286, p = 0.042) scores, as well as plasma IL-6 levels (r = -0.294, p = 0.036), with mean decreased functional connectivity (FC) in MDD patients. Additionally, physical abuse exhibited a positive correlation with the nodal clustering coefficient of the left thalamus in patients (r = 0.306, p = 0.029). Exploratory analysis indicated negative correlations between CTQ total and emotional neglect scores and mean decreased FC in MDD patients with lower plasma IL-6 levels (n = 28), while these correlations were nonsignificant in MDD patients with higher plasma IL-6 levels (n = 28).Conclusions: This finding enhances our understanding of the correlation between childhood trauma experiences, inflammation, and brain activity in MDD, suggesting potential variations in their underlying pathophysiological mechanisms.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1063-1074"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant brain dynamics in major depressive disorder during working memory task. 重度抑郁障碍患者在完成工作记忆任务时的大脑动态变化异常。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-07-08 DOI: 10.1007/s00406-024-01854-4

Fuping Sun, Zhening Liu, Jun Yang, Zebin Fan, Feiwen Wang, Jie Yang

{"title":"Aberrant brain dynamics in major depressive disorder during working memory task.","authors":"Fuping Sun, Zhening Liu, Jun Yang, Zebin Fan, Feiwen Wang, Jie Yang","doi":"10.1007/s00406-024-01854-4","DOIUrl":"10.1007/s00406-024-01854-4","url":null,"abstract":"Working memory (WM) is a distributed and dynamic process, and WM deficits are recognized as one of the top-ranked endophenotype candidates for major depressive disorders (MDD). However, there is a lack of knowledge of brain temporal-spatial profile of WM deficits in MDD. We used the dynamical degree centrality (dDC) to investigate the whole-brain temporal-spatial profile in 40 MDD and 40 controls during an n-back task with 2 conditions (i.e., '0back' and '2back'). We explored the dDC temporal variability and clustered meta-stable states in 2 groups during different WM conditions. Pearson's correlation analysis was used to evaluate the relationship between the altered dynamics with clinical symptoms and WM performance. Compared with controls, under '2back vs. 0back' contrast, patients showed an elevated dDC variability in wide range of brain regions, including the middle frontal gyrus, orbital part of inferior frontal gyrus (IFGorb), hippocampus, and middle temporal gyrus. Furthermore, the increased dDC variability in the hippocampus and IFGorb correlated with worse WM performance. However, there were no significant group-related differences in the meta-stable states were observed. This study demonstrated the increased WM-related instability (i.e., the elevated dDC variability) was represented in MDD, and enhancing stability may help patients achieve better WM performance.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1141-1150"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study. 阈下抑郁症患者静态和动态功能网络连接的改变：大规模静息态 fMRI 研究。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-07-24 DOI: 10.1007/s00406-024-01871-3

Dan Liao, Li-Song Liang, Di Wang, Xiao-Hai Li, Yuan-Cheng Liu, Zhi-Peng Guo, Zhu-Qing Zhang, Xin-Feng Liu

{"title":"Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.","authors":"Dan Liao, Li-Song Liang, Di Wang, Xiao-Hai Li, Yuan-Cheng Liu, Zhi-Peng Guo, Zhu-Qing Zhang, Xin-Feng Liu","doi":"10.1007/s00406-024-01871-3","DOIUrl":"10.1007/s00406-024-01871-3","url":null,"abstract":"Dynamic functional network connectivity (dFNC) is an expansion of static FNC (sFNC) that reflects connectivity variations among brain networks. This study aimed to investigate changes in sFNC and dFNC strength and temporal properties in individuals with subthreshold depression (StD). Forty-two individuals with subthreshold depression and 38 healthy controls (HCs) were included in this study. Group independent component analysis (GICA) was used to determine target resting-state networks, namely, executive control network (ECN), default mode network (DMN), sensorimotor network (SMN) and dorsal attentional network (DAN). Sliding window and k-means clustering analyses were used to identify dFNC patterns and temporal properties in each subject. We compared sFNC and dFNC differences between the StD and HCs groups. Relationships between changes in FNC strength, temporal properties, and neurophysiological score were evaluated by Spearman's correlation analysis. The sFNC analysis revealed decreased FNC strength in StD individuals, including the DMN-CEN, DMN-SMN, SMN-CEN, and SMN-DAN. In the dFNC analysis, 4 reoccurring FNC patterns were identified. Compared to HCs, individuals with StD had increased mean dwell time and fraction time in a weakly connected state (state 4), which is associated with self-focused thinking status. In addition, the StD group demonstrated decreased dFNC strength between the DMN-DAN in state 2. sFNC strength (DMN-ECN) and temporal properties were correlated with HAMD-17 score in StD individuals (all p < 0.01). Our study provides new evidence on aberrant time-varying brain activity and large-scale network interaction disruptions in StD individuals, which may provide novel insight to better understand the underlying neuropathological mechanisms.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1099-1112"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nightmare frequency and nightmare distress in psychiatric inpatients. 精神病住院患者的噩梦频率和噩梦困扰。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-09-09 DOI: 10.1007/s00406-024-01891-z

Michael Schredl, Elisabeth Anzenberger, Claudia Schilling

引用次数: 0

Psychosocial factors affect the occurrence of nonsuicidal self-injury in adolescents with major depressive disorder through chain mediation. 心理社会因素通过连锁中介影响重度抑郁障碍青少年非自杀性自伤的发生。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-06-01 Epub Date: 2024-07-08 DOI: 10.1007/s00406-024-01858-0

Tian Ren, Yujiao Wen, Lu Ma, Dan Qiao, Gaizhi Li, Hong Li, Xiao Wang, Zhifen Liu

{"title":"Psychosocial factors affect the occurrence of nonsuicidal self-injury in adolescents with major depressive disorder through chain mediation.","authors":"Tian Ren, Yujiao Wen, Lu Ma, Dan Qiao, Gaizhi Li, Hong Li, Xiao Wang, Zhifen Liu","doi":"10.1007/s00406-024-01858-0","DOIUrl":"10.1007/s00406-024-01858-0","url":null,"abstract":"In the adolescent group, about half of adolescents with major depressive disorder (MDD) have NSSI. Psychosocial factors are associated with the development of NSSI. Clarifying the relationship between psychosocial factors and NSSI in adolescents with MDD can help us achieve early prevent. Demographic data, Hamilton Depression Scale-24 (HAMA24), childhood trauma questionnaire, emotional intelligence scale and interpersonal reactivity index were collected from 187 adolescents with MDD. Use ANOVA, Chi-square test, Binary Logistic Regression, Pearson correlation analysis, Mediation effect analysis and the Structural Equation Model for data analysis. The results of ANOVA showed that there was significant difference between the two groups in HAMD24 total score, impulsiveness, emotional intelligence, and empathy (p < 0.05). In the regression analysis, women, depression degree, motor impulsiveness (MI), personal distress (PD) and appraisal of other's emotions empathy were the risk factors for MDD adolescents to produce NSSI behavior. Among the indicators that were significantly related to MDD and NSSI, MI and PD mediate the relationship between MDD and NSSI. The structural equation model showed that MDD, PD and MI had a direct impact on NSSI, but PD and MI had multiple intermediary effected in the relationship between MDD and NSSI. Emotional intelligence, emotional neglect and cognitive impulsiveness indirectly affected the occurrence of NSSI behavior. Impulsiveness, personal distress, emotional neglect, and emotional intelligence are important risk factors that affect NSSI behavior in adolescents with MDD, and they affect the occurrence of NSSI in adolescents with MDD through chain mediation.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1209-1220"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of brain structure with psychopathy. 脑结构与精神病的关系。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-05-29 DOI: 10.1007/s00406-025-02028-6

Peter Pieperhoff, Lena Hofhansel, Frank Schneider, Jürgen Müller, Katrin Amunts, Sabrina Weber-Papen, Carmen Weidler, Benjamin Clemens, Adrian Raine, Ute Habel

{"title":"Associations of brain structure with psychopathy.","authors":"Peter Pieperhoff, Lena Hofhansel, Frank Schneider, Jürgen Müller, Katrin Amunts, Sabrina Weber-Papen, Carmen Weidler, Benjamin Clemens, Adrian Raine, Ute Habel","doi":"10.1007/s00406-025-02028-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02028-6","url":null,"abstract":"Psychopathy is one of the greatest risk factors for serious and persistent violence. In order to detect its neurobiological substrates, we examined 39 male psychopathic subjects and matched controls using structural MR imaging and the Psychopathy Check-List (PCL-R). Individual brain region volumes were calculated using the Julich-Brain and AAL3 atlases. Associations of region volumes with the PCL-R dimensions among psychopathic subjects and differences between both groups were analysed. PCL-R factor 2 assessing lifestyle and antisocial behaviour showed in the psychopathic sample negative associations with volumes of several regions, including pons, nuclei of basal ganglia, thalamus, basal forebrain (CH-4), cerebellar regions and areas in orbitofrontal, dorsolateral-frontal and insular cortices. These findings suggest dysfunctions in specific frontal-subcortical circuits, which are known to be relevant for behavioral control. In contrast, the interpersonal-affective PCL-R factor 1 showed only weak positive and negative associations with orbitofrontal, dorsolateral-frontal and left hippocampal areas (CA1, subiculum), among others, indicating that involved brain regions might be affected to a variable degree in different individuals. The group comparison yielded a significantly reduced total brain volume in psychopathic subjects relative to controls, while pronounced regional focuses of volume differences were found only in the right subiculum, suggesting an interindividually variable pattern of structural deviations in the brains of psychopathic subjects. In conclusion, these findings are compatible with the dimensionality of the PCL-R construct, and suggest a particulary strong association of antisocial behavior to smaller volumes in widespread subcortical-cortical brain regions.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

J-shaped association between the neutrophil percentage-to-albumin ratio (NPAR) and depression: analyses of NHANES 2005-2018. 中性粒细胞百分比-白蛋白比（NPAR）与抑郁症之间的j型关联：NHANES 2005-2018分析

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-05-29 DOI: 10.1007/s00406-025-02024-w

Ruirui Tan, Xiaomei Zhang, Chao Han, Tong Liu, Hongdong Sun, Rui Yun, Chenxi Qi, Zhaohui Wang

{"title":"J-shaped association between the neutrophil percentage-to-albumin ratio (NPAR) and depression: analyses of NHANES 2005-2018.","authors":"Ruirui Tan, Xiaomei Zhang, Chao Han, Tong Liu, Hongdong Sun, Rui Yun, Chenxi Qi, Zhaohui Wang","doi":"10.1007/s00406-025-02024-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02024-w","url":null,"abstract":"Inflammation is an essential driving factor in the development of depression, but the relationship between the composite indicator of neutrophil percentage to albumin ratio (NPAR) and susceptibility or progression of depression remains to be elucidated. On June 5, 2024, we utilized the publicly available NHANES database and collected data from 2005 to 2018 for a cross-sectional analysis. The PHQ-9 questionnaire was used to assess the level of depression, and NPAR was expressed as neutrophil percentage/albumin. Weighted logistic regression models and RCS were used to investigate the relationship between NPAR and the risk of depression. In addition, subgroup analyses and sensitivity analyses were performed to test the robustness of the results. Our results revealed a non-linear association between NPAR and the likelihood of depression (P-value for non-linearity < 0.001). In a continuous variable model, there was a positive association between NPAR and risk of depression after full adjustment for covariates (OR: 1.58, 95% CI: 1.11-2.25, P = 0.010). In the fully adjusted model, participants in the fourth quartile (NPAR ≥ 1.53) had an OR of 1.36 (95% CI: 1.04-1.78, P < 0.05), showing a significant association with a higher likelihood of depression. Compared to the first quartile (Q1), PHQ-9 scores ranging from 15 to 19 had the highest odds ratio in Q4 (OR: 2.17, 95% CI: 1.73-2.73, P < 0.001). NPAR showed a J-shaped relationship with the risk of developing depression. The results of this study highlight the importance of NPAR in identifying patients at risk of depression.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new direction for adjunctive therapy of difficult-to-treat depression: examining the role of orexin receptor antagonists. 难治性抑郁症辅助治疗的新方向：探讨食欲素受体拮抗剂的作用。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-05-28 DOI: 10.1007/s00406-025-01999-w

Michael E Thase

{"title":"A new direction for adjunctive therapy of difficult-to-treat depression: examining the role of orexin receptor antagonists.","authors":"Michael E Thase","doi":"10.1007/s00406-025-01999-w","DOIUrl":"https://doi.org/10.1007/s00406-025-01999-w","url":null,"abstract":"One of the several pressing unmet needs in the pharmacotherapy of MDD is development of drugs with novel mechanisms of action that can effectively treat depressed patients who do not respond to first- and second-line antidepressants. The value of identifying such a medication would be enhanced if it were also generally well-tolerated and addressed depressive symptoms that are less responsive to SSRIs or SNRIs, such as insomnia or anxiety. This narrative review summarizes the investigation of a novel class of medications originally developed to treat insomnia, the Orexin Receptor Antagonists (ORAs), as adjunctive treatments for depressed patients who have been able to tolerate but who do not obtain an adequate response to standard antidepressants. Although it is likely that the currently approved Dual Orexin Receptor Antagonists (DORAs)-suvorexant, lemborexant and daridorexant-are safe and useful options for concomitant therapy of insomnia in antidepressant-treated patients, these medications have not been approved for this indication. Moreover, DORAs have not been extensively studied as adjunctive therapies for MDD. By contrast, the investigational ORA seltorexant, which is a selective Orexin 2 receptor antagonist, has shown significant antidepressant effects in Phase 2 and Phase 3 trials. Although at least one more unequivocally positive pivotal study will be needed to garner FDA approval for clinical use in the United States, this drug shows promise as a novel and well-tolerated option for patients with difficult to treat depressive episodes.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Mild motor signs and depression: more than just medication side effects? 纠正：轻度运动症状和抑郁：不仅仅是药物副作用？

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-05-21 DOI: 10.1007/s00406-025-02026-8

Antonina Luca, Maria Luca, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Raffaella Zanardi, Raffaele Ferri, Bartolo Lanuzza, Basilio Pecorino, Bernhard T Baune, Giuseppe Fanelli, Chiara Fabbri, Alessandro Serretti

引用次数: 0

Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia. 首次发作antipsychotic-naïve精神分裂症事件相关电位的性别差异及其临床预测价值。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-05-21 DOI: 10.1007/s00406-025-02020-0

Qin Qin, Chenghao Lu, Shaobing Li, Nannan Liu, Yanzhe Li, Tongxin Li, Yeqing Dong, Xinxu Wang, Shen Li, Jie Li, Xiang Yang Zhang

{"title":"Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia.","authors":"Qin Qin, Chenghao Lu, Shaobing Li, Nannan Liu, Yanzhe Li, Tongxin Li, Yeqing Dong, Xinxu Wang, Shen Li, Jie Li, Xiang Yang Zhang","doi":"10.1007/s00406-025-02020-0","DOIUrl":"https://doi.org/10.1007/s00406-025-02020-0","url":null,"abstract":"This study explored sex differences in cognitive impairments in first-episode antipsychotic-naive schizophrenia (FEAN-SZ) patients using event-related potentials. A total of 321 FEAN-SZ patients and 146 healthy controls (HCs) were enrolled to compare sex differences in the P300 (P3) components elicited by the auditory Oddball paradigm. The Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA) were used to assess the clinical symptoms. We also examined sex differences in the relationship between P3 components and clinical symptoms. Compared to HCs, FEAN-SZ patients showed reduced P3 amplitude and prolonged latency (all ps < 0.001). Male patients had significantly lower N100 (N1) amplitude than female patients (F = 5.70, p = 0.018), a difference not observed in HCs. In males, N1 latency correlated with total PANSS (r = 0.361, p < 0.001) and general psychopathology scores (r = 0.354, p < 0.001). Multiple stepwise regression showed that N1 amplitude predicted negative, total PANSS, and HAMD scores in males (β = -0.263, -0.191, -0.289, all ps < 0.001). In females, P3a latency predicted G, total PANSS, HAMD, and HAMA scores (β = 0.486, 0.600, 0.204, 0.297, all ps < 0.05). FEAN-SZ patients exhibited reduced P3 amplitude and prolonged latency compared to HCs, with males showing lower N100 amplitude than females. In terms of sex-specific clinical symptom predictors, N1 amplitude in males and P3a latency in females were significantly correlated with PANSS, HAMD, and HAMA scores.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0