Neurophysiological features in women with antenatal depressive symptoms: a resting-state quantitative electroencephalography study.

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY
Hyeon Ji Kim, Daseul Lee, Jinuk Kim, Na Young Kim, Subeen Hong, Woojae Myung, Hyukjun Lee, Jee Yoon Park
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Abstract

Background: Antenatal depression, which is prevalent during pregnancy, frequently continues into the postpartum period. We aimed to investigate the potential neurophysiological brain changes in women exhibiting antenatal depressive symptoms, using resting-state quantitative electroencephalography (qEEG) patterns as an objective indicator.

Methods: Pregnant women with high-risk conditions were included and evaluated for antenatal depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS), then divided into groups based on an EPDS score of 10. Resting-state qEEG recordings were then obtained to assess relative power topography within classical frequency bands, comparing these measures across the two groups and examining their correlation with EPDS scores.

Results: Among 36 participants, 12 scored ≥ 10 on the EPDS, indicative of significant depressive symptoms, while 24 scored < 10. Those with scores ≥ 10 exhibited heightened beta power in frontal areas (Fz and F4; p < 0.05), along with significant alpha and theta band asymmetry at the T3/T4 (r = 0.383, p = 0.021) and P3/P4 (r = 0.369, p = 0.027) sites respectively, positively correlating with EPDS scores.

Limitations: Depressive symptoms were solely evaluated according to the EPDS, which is a screening tool. Additional limitations include the cross-sectional study design and the relatively small sample size, necessitating cautious interpretation of the results.

Conclusion: The distinct qEEG patterns observed in women with EPDS scores ≥ 10 highlight the potential of qEEG as an objective indicator for assessing antenatal depression.

产前抑郁症状妇女的神经生理特征:静息状态定量脑电图研究
背景:产前抑郁,这是普遍在怀孕期间,经常持续到产后时期。我们的目的是利用静息状态定量脑电图(qEEG)模式作为客观指标,研究表现出产前抑郁症状的妇女潜在的神经生理脑变化。方法:采用爱丁堡产后抑郁量表(EPDS)对高危孕妇进行产前抑郁症状评估,并根据EPDS评分10分进行分组。然后获得静息状态qEEG记录,以评估经典频段内的相对功率分布,比较两组的这些测量结果,并检查它们与EPDS评分的相关性。结果:36名受试者中,有12人的EPDS得分≥10分,表明存在明显的抑郁症状,24人得分为:局限性:抑郁症状仅根据EPDS进行评估,这是一种筛查工具。其他限制包括横断面研究设计和相对较小的样本量,需要谨慎解释结果。结论:在EPDS评分≥10的女性中观察到不同的qEEG模式,突出了qEEG作为评估产前抑郁的客观指标的潜力。
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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
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