Alexithymia as a mechanistic bridge: validating the mediating role of emotion processing deficits between childhood trauma and negative symptoms in schizophrenia.

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY
Kui Zhang, Shan Tao, Chengqiang Jin
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引用次数: 0

Abstract

This pioneering study published in European Archives of Psychiatry and Clinical Neuroscience elucidates the mediating role of alexithymia-specifically difficulty identifying feelings (DIF) and externally oriented thinking (EOT)-in the pathway linking childhood trauma (CT) to negative symptoms (NS) in chronic schizophrenia (β < sub > DIF = 0.04, 95% CI [0.002, 0.085]; β < sub > EOT = 0.03, 95% CI [0.002, 0.060]). Using Hayes' PROCESS macro with bootstrapping in 94 patients, the authors establish alexithymia as a mechanistically actionable target for trauma-informed interventions. Methodological refinements are proposed to address antipsychotic class effects on emotion processing, neurobiological mediators (e.g., amygdala volume), and positive symptom confounding. This work redefines therapeutic paradigms for trauma-associated schizophrenia, underscoring the journal's leadership in transformative clinical neuroscience.

述情障碍作为一个机制桥梁:验证情绪加工缺陷在童年创伤和精神分裂症阴性症状之间的中介作用。
这项发表在《欧洲精神病学和临床神经科学档案》上的开创性研究阐明了述情障碍——特别是情感识别困难(DIF)和外向性思维(EOT)——在慢性精神分裂症儿童创伤(CT)与阴性症状(NS)之间的通路中的中介作用(β DIF = 0.04, 95% CI [0.002, 0.085];β eot = 0.03, 95% ci[0.002, 0.060])。在94名患者中使用Hayes的PROCESS宏,作者将述情障碍作为创伤知情干预的机制上可操作的目标。提出了方法上的改进,以解决抗精神病类药物对情绪处理、神经生物学介质(如杏仁核体积)和阳性症状混淆的影响。这项工作重新定义了创伤性精神分裂症的治疗范式,强调了该杂志在变革性临床神经科学方面的领导地位。
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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
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