Epidemiology and Infection最新文献_第5页

Everything but the kitchen sink: The use of multiple hypothesis generation methods to investigate an outbreak of Salmonella Enteritidis associated with frozen profiteroles and eclairs. 除厨房水槽外的一切：使用多种假设生成方法调查与冷冻杏仁饼和杏仁蛋糕有关的肠炎沙门氏菌疫情。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-09-30 DOI: 10.1017/S0950268824001067

Courtney R Smith, Marsha Taylor, Anna J W Manore, April Hexemer, Bijay Adhikari, David Alexander, Robin Atkinson, Linda Chui, Eleni Galanis, Colette Gaulin, Meghan Griffin, Lance Honish, Ashley Kearney, Victor Mah, Rachel McCormick, Michelle Murti

{"title":"Everything but the kitchen sink: The use of multiple hypothesis generation methods to investigate an outbreak of Salmonella Enteritidis associated with frozen profiteroles and eclairs.","authors":"Courtney R Smith, Marsha Taylor, Anna J W Manore, April Hexemer, Bijay Adhikari, David Alexander, Robin Atkinson, Linda Chui, Eleni Galanis, Colette Gaulin, Meghan Griffin, Lance Honish, Ashley Kearney, Victor Mah, Rachel McCormick, Michelle Murti","doi":"10.1017/S0950268824001067","DOIUrl":"10.1017/S0950268824001067","url":null,"abstract":"In December 2018, an outbreak of Salmonella Enteritidis infections was identified in Canada by whole-genome sequencing (WGS). An investigation was initiated to identify the source of the illnesses, which proved challenging and complex. Microbiological hypothesis generation methods included comparisons of Salmonella isolate sequence data to historical domestic outbreaks and international repositories. Epidemiological hypothesis generation methods included routine case interviews, open-ended centralized re-interviewing, thematic analysis of open-ended interview data, collection of purchase records, a grocery store site visit, analytic comparison to healthy control groups, and case-case analyses. Food safety hypothesis testing methods included food sample collection and analysis, and traceback investigations. Overall, 83 cases were identified across seven provinces, with onset dates from 6 November 2018 to 7 May 2019. Case ages ranged from 1 to 88 years; 60% (50/83) were female; 39% (22/56) were hospitalized; and three deaths were reported. Brand X profiteroles and eclairs imported from Thailand were identified as the source of the outbreak, and eggs from an unregistered facility were hypothesized as the likely cause of contamination. This study aims to describe the outbreak investigation and highlight the multiple hypothesis generation methods that were employed to identify the source.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e107"},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukins in the pathogenesis of influenza and other acute respiratory viral infections. 流感和其他急性呼吸道病毒感染发病机制中的白细胞介素。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-09-30 DOI: 10.1017/S0950268824001109

Mykchaylo Andreychyn, Larysa Melnyk, Nataliia Zavidniiuk, Natalya Nychyk, Iaryna Iosyk

{"title":"Interleukins in the pathogenesis of influenza and other acute respiratory viral infections.","authors":"Mykchaylo Andreychyn, Larysa Melnyk, Nataliia Zavidniiuk, Natalya Nychyk, Iaryna Iosyk","doi":"10.1017/S0950268824001109","DOIUrl":"10.1017/S0950268824001109","url":null,"abstract":"Influenza and other acute respiratory viral infections (ARVIs) are among the most common human diseases. In recent decades, the discovery of cytokines and their significance in the pathogenesis of diseases has led to extensive research on these compounds in various pathologies including ARVIs. The aim of the research was to study the cytokine profile in patients with ARVIs. The cases of 30 patients were investigated. Etiological diagnosis was performed by polymerase chain reaction. Different classes of cytokines in the serum were defined by the enzyme-linked immunosorbent assay (ELISA). The level of cytokines depended on the number of pathogens. The highest levels of pro-inflammatory interleukins and the lowest levels of anti-inflammatory IL-4 were observed in patients with a combination of five or more viruses compared to those with a monoinfection. Analysis of the data showed that in the acute phase, the levels of all studied pro-inflammatory cytokines - IL-2, IL-6, and TNF-α - increased by 8, 39, and 9 times, respectively, compared to those in healthy individuals. In the acute phase of ARVI, the levels of pro-inflammatory cytokines were significantly higher and depended on the severity of the disease. The imbalance of cytokines in the serum has been established in cases of ARVIs, depending on the severity of the disease.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e109"},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The incubation for urethral gonorrhoea among men who have sex with men with and without oropharyngeal gonorrhoea. 有口咽淋病和无口咽淋病的男男性行为者中尿道淋病的潜伏期。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-09-27 DOI: 10.1017/S095026882400089X

Julien Tran, Christopher K Fairley, Jason J Ong, Tiffany R Phillips, Ei T Aung, Eric P F Chow

{"title":"The incubation for urethral gonorrhoea among men who have sex with men with and without oropharyngeal gonorrhoea.","authors":"Julien Tran, Christopher K Fairley, Jason J Ong, Tiffany R Phillips, Ei T Aung, Eric P F Chow","doi":"10.1017/S095026882400089X","DOIUrl":"https://doi.org/10.1017/S095026882400089X","url":null,"abstract":"We hypothesized that the incubation for urethral gonorrhoea would be longer for men with oropharyngeal gonorrhoea than those without oropharyngeal gonorrhoea. We conducted a chart review of men who have sex with men with urethral gonorrhoea symptoms at a sexual health clinic between 2019 and 2021. The incubation period was defined as the number of days between men's last sexual contact and onset of symptoms. We used a Mann-Whitney U test to compare differences in the median incubation for urethral gonorrhoea between men with and men without oropharyngeal gonorrhoea. There were 338 men with urethral symptoms (median age = 32 years; IQR: 28-39), and of these, 307 (90.1%) were tested for oropharyngeal gonorrhoea, of whom 124 (40.4%, 95% CI: 34.9-46.1) men had oropharyngeal and urethral gonorrhoea. We analyzed incubation data available for 190 (61.9%) of the 307 men, with 38.9% (74/190) testing positive for oropharyngeal gonorrhoea. The incubation for urethral gonorrhoea did not differ between 74 men (39%) with oropharyngeal gonorrhoea (median = 4 days; IQR: 2-6) and 116 men (61%) without oropharyngeal gonorrhoea (median = 2.5 days; IQR: 1-5) (p = 0.092). Research is needed to investigate gonorrhoea transmission from the oropharynx to the urethra.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e104"},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omicron incidence and seroprevalence among children in Montreal, Canada, in early 2023: final results from the longitudinal EnCORE serology study. 2023 年初加拿大蒙特利尔儿童的奥米克原发病率和血清流行率：EnCORE 血清学纵向研究的最终结果。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-09-25 DOI: 10.1017/S0950268824000797

Katia Charland, Laura Pierce, Adrien Saucier, Marie-Ève Hamelin, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach, Kate Zinszer

{"title":"Omicron incidence and seroprevalence among children in Montreal, Canada, in early 2023: final results from the longitudinal EnCORE serology study.","authors":"Katia Charland, Laura Pierce, Adrien Saucier, Marie-Ève Hamelin, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach, Kate Zinszer","doi":"10.1017/S0950268824000797","DOIUrl":"https://doi.org/10.1017/S0950268824000797","url":null,"abstract":"Since early 2022, routine testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on symptoms and exposure history has largely ceased in Canada. Consequently, seroprevalence studies, particularly longitudinal studies, have become critical for monitoring the rate of incident SARS-CoV-2 infections and the proportion of the population with evidence of immunity. EnCORE is a longitudinal SARS-CoV-2 seroprevalence study comprising five rounds of serology testing from October 2020 to June 2023, in a sample of 2- to 17-year-olds (at baseline), recruited from daycares and schools in four neighbourhoods of Montreal, Canada. We report on SARS-CoV-2 incidence and seroprevalence among the 509 participants in the fifth and final round of the study. Seroprevalence of antibodies from either infection or vaccination was 98% (95 per cent confidence interval [CI]: 97, 99). The infection-acquired seroprevalence was 78% (95% CI: 73-82), and the incidence rate was 113 per 100 person-years (95% CI: 94-132), compared to the seroprevalence of 58% and the incidence rate of 133 per 100 person-years, respectively, in the fourth round of testing (mid-late 2022). Of the 131 participants newly seropositive for infection in Round 4, only 18 were seronegative for infection in Round 5 (median follow-up: 326 days).","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e103"},"PeriodicalIF":2.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe acute respiratory syndrome coronavirus 2-reactive salivary antibody detection in South Carolina emergency healthcare workers, September 2019-March 2020. 2019 年 9 月至 2020 年 3 月，在南卡罗来纳州急诊医护人员中检测严重急性呼吸系统综合征冠状病毒 2 反应性唾液抗体。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-09-25 DOI: 10.1017/S0950268824000967

Haley C Meltzer, Jane L Goodwin, Lauren A Fowler, Thomas W Britt, Ronald G Pirrallo, Jennifer T Grier

{"title":"Severe acute respiratory syndrome coronavirus 2-reactive salivary antibody detection in South Carolina emergency healthcare workers, September 2019-March 2020.","authors":"Haley C Meltzer, Jane L Goodwin, Lauren A Fowler, Thomas W Britt, Ronald G Pirrallo, Jennifer T Grier","doi":"10.1017/S0950268824000967","DOIUrl":"https://doi.org/10.1017/S0950268824000967","url":null,"abstract":"On 19 January 2020, the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was identified in the United States, with the first cases in South Carolina confirmed on 06 March 2020. Due to initial limited testing capabilities and potential for asymptomatic transmission, it is possible that SARS-CoV-2 may have been present earlier than previously thought, while the immune status of at-risk populations was unknown. Saliva from 55 South Carolina emergency healthcare workers (EHCWs) was collected from September 2019 to March 2020, pre- and post-healthcare shifts, and stored frozen. To determine the presence of SARS-CoV-2-reactive antibodies, saliva-acquired post-shift was analysed by enzyme-linked immunosorbent assay (ELISA) with a repeat of positive or inconclusive results and follow-up testing of pre-shift samples. Two participants were positive for SARS-CoV-2 N/S1-reactive IgG, confirmed by follow-up testing, with S1 receptor binding domain (RBD)-specific IgG present in one individual. Positive samples were collected from medical students working in emergency medical services (EMSs) in October or November 2019. The presence of detectable anti-SARS-CoV-2 antibodies in 2019 suggests that immune responses to the virus existed in South Carolina, and the United States, in a small percentage of EHCWs prior to the earliest documented coronavirus disease 2019 (COVID-19) cases. These findings suggest the feasibility of saliva as a noninvasive tool for surveillance of emerging outbreaks, and EHCWs represent a high-risk population that should be the focus of infectious disease surveillance.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e102"},"PeriodicalIF":2.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surveillance of SARS-CoV-2 prevalence from repeated pooled testing: application to Swiss routine data. 通过重复联合检测监测 SARS-CoV-2 流行情况：应用于瑞士常规数据。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000876

Julien Riou, Erik Studer, Anna Fesser, Tobias Magnus Schuster, Nicola Low, Matthias Egger, Anthony Hauser

{"title":"Surveillance of SARS-CoV-2 prevalence from repeated pooled testing: application to Swiss routine data.","authors":"Julien Riou, Erik Studer, Anna Fesser, Tobias Magnus Schuster, Nicola Low, Matthias Egger, Anthony Hauser","doi":"10.1017/S0950268824000876","DOIUrl":"https://doi.org/10.1017/S0950268824000876","url":null,"abstract":"Surveillance of SARS-CoV-2 through reported positive RT-PCR tests is biased due to non-random testing. Prevalence estimation in population-based samples corrects for this bias. Within this context, the pooled testing design offers many advantages, but several challenges remain with regards to the analysis of such data. We developed a Bayesian model aimed at estimating the prevalence of infection from repeated pooled testing data while (i) correcting for test sensitivity; (ii) propagating the uncertainty in test sensitivity; and (iii) including correlation over time and space. We validated the model in simulated scenarios, showing that the model is reliable when the sample size is at least 500, the pool size below 20, and the true prevalence below 5%. We applied the model to 1.49 million pooled tests collected in Switzerland in 2021-2022 in schools, care centres, and workplaces. We identified similar dynamics in all three settings, with prevalence peaking at 4-5% during winter 2022. We also identified differences across regions. Prevalence estimates in schools were correlated with reported cases, hospitalizations, and deaths (coefficient 0.84 to 0.90). We conclude that in many practical situations, the pooled test design is a reliable and affordable alternative for the surveillance of SARS-CoV-2 and other viruses.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e100"},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review and meta-analysis of ambient temperature and precipitation with infections from five food-borne bacterial pathogens. 环境温度和降水与五种食源性细菌病原体感染的系统回顾和荟萃分析。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000839

Naveen Manchal, Megan K Young, Maria Eugenia Castellanos, Peter Leggat, Oyelola Adegboye

{"title":"A systematic review and meta-analysis of ambient temperature and precipitation with infections from five food-borne bacterial pathogens.","authors":"Naveen Manchal, Megan K Young, Maria Eugenia Castellanos, Peter Leggat, Oyelola Adegboye","doi":"10.1017/S0950268824000839","DOIUrl":"10.1017/S0950268824000839","url":null,"abstract":"Studies on climate variables and food pathogens are either pathogen- or region-specific, necessitating a consolidated view on the subject. This study aims to systematically review all studies on the association of ambient temperature and precipitation on the incidence of gastroenteritis and bacteraemia from Salmonella, Shigella, Campylobacter, Vibrio, and Listeria species. PubMed, Ovid MEDLINE, Scopus, and Web of Science databases were searched up to 9 March 2023. We screened 3,204 articles for eligibility and included 83 studies in the review and three in the meta-analysis. Except for one study on Campylobacter, all showed a positive association between temperature and Salmonella, Shigella, Vibrio sp., and Campylobacter gastroenteritis. Similarly, most of the included studies showed that precipitation was positively associated with these conditions. These positive associations were found regardless of the effect measure chosen. The pooled incidence rate ratio (IRR) for the three studies that included bacteraemia from Campylobacter and Salmonella sp. was 1.05 (95 per cent confidence interval (95% CI): 1.03, 1.06) for extreme temperature and 1.09 (95% CI: 0.99, 1.19) for extreme precipitation. If current climate trends continue, our findings suggest these pathogens would increase patient morbidity, the need for hospitalization, and prolonged antibiotic courses.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e98"},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Campylobacter diversity in retail chicken: epidemiologically important strains may be missed with current sampling methods. 零售鸡肉中弯曲杆菌的高度多样性：目前的采样方法可能会遗漏具有流行病学意义的菌株。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000906

Agata H Dziegiel, Samuel J Bloomfield, George M Savva, Raphaëlle Palau, Nicol Janecko, John Wain, Alison E Mather

{"title":"High Campylobacter diversity in retail chicken: epidemiologically important strains may be missed with current sampling methods.","authors":"Agata H Dziegiel, Samuel J Bloomfield, George M Savva, Raphaëlle Palau, Nicol Janecko, John Wain, Alison E Mather","doi":"10.1017/S0950268824000906","DOIUrl":"https://doi.org/10.1017/S0950268824000906","url":null,"abstract":"Campylobacter spp. are leading bacterial gastroenteritis pathogens. Infections are largely underreported, and the burden of outbreaks may be underestimated. Current strategies of testing as few as one isolate per sample can affect attribution of cases to epidemiologically important sources with high Campylobacter diversity, such as chicken meat. Multiple culture method combinations were utilized to recover and sequence Campylobacter from 45 retail chicken samples purchased across Norwich, UK, selecting up to 48 isolates per sample. Simulations based on resampling were used to assess the impact of Campylobacter sequence type (ST) diversity on outbreak detection. Campylobacter was recovered from 39 samples (87%), although only one sample was positive through all broth, temperature, and plate combinations. Three species were identified (Campylobacter jejuni, Campylobacter coli, and Campylobacter lari), and 33% of samples contained two species. Positive samples contained 1-8 STs. Simulation revealed that up to 87 isolates per sample would be required to detect 95% of the observed ST diversity, and 26 isolates would be required for the average probability of detecting a random theoretical outbreak ST to reach 95%. An optimized culture approach and selecting multiple isolates per sample are essential for more complete Campylobacter recovery to support outbreak investigation and source attribution.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e101"},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students - CORRIGENDUM. 瑞典大学生脑膜炎奈瑟氏菌携带率和持久性 - CORRIGENDUM。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000840

Olof Säll, Lorraine Eriksson, Idosa Asfaw Berhane, Alexander Persson, Anders Magnuson, Sara Thulin Hedberg, Martin Sundqvist, Per Olcén, Hans Fredlund, Bianca Stenmark, Eva Särndahl, Paula Mölling, Susanne Jacobsson

引用次数: 0

Risk of central line-associated bloodstream infections during COVID-19 pandemic in intensive care patients in a tertiary care centre in Saudi Arabia. 沙特阿拉伯一家三级医疗中心的重症监护患者在 COVID-19 大流行期间发生中心静脉相关血流感染 (CLABSI) 的风险。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-06-03 DOI: 10.1017/S0950268824000736

Majid M Alshamrani, Aiman El-Saed, Omar Aldayhani, Abdulaziz Alhassan, Abdullah Alhamoudi, Mohammed Alsultan, Mohammed Alrasheed, Fatmah Othman

{"title":"Risk of central line-associated bloodstream infections during COVID-19 pandemic in intensive care patients in a tertiary care centre in Saudi Arabia.","authors":"Majid M Alshamrani, Aiman El-Saed, Omar Aldayhani, Abdulaziz Alhassan, Abdullah Alhamoudi, Mohammed Alsultan, Mohammed Alrasheed, Fatmah Othman","doi":"10.1017/S0950268824000736","DOIUrl":"10.1017/S0950268824000736","url":null,"abstract":"This retrospective study compared central line-associated bloodstream infection (CLABSI) rates per 1 000 central line days, and overall mortality before and during the COVID-19 pandemic in adult, paediatric, and neonatal ICU patients at King Abdul-Aziz Medical City-Riyadh who had a central line and were diagnosed with CLABSI according to the National Healthcare Safety Network standard definition. The study spanned between January 2018 and December 2019 (pre-pandemic), and January 2020 and December 2021 (pandemic). SARS-CoV-2 was confirmed by positive RT-PCR testing. The study included 156 CLABSI events and 46 406 central line days; 52 and 22 447 (respectively) in pre-pandemic, and 104 and 23 959 (respectively) during the pandemic. CLABSI rates increased by 2.02 per 1 000 central line days during the pandemic period (from 2.32 to 4.34, p < 0.001). Likewise, overall mortality rates increased by 0.86 per 1 000 patient days (from 0.93 to 1.79, p = 0.003). Both CLABSI rates (6.18 vs. 3.7, p = 0.006) and overall mortality (2.72 vs. 1.47, p = 0.014) were higher among COVID-19 patients compared to non-COVID-19 patients. The pandemic was associated with a substantial increase in CLABSI-associated morbidity and mortality.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e95"},"PeriodicalIF":2.5,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0