Molecular epidemiological surveillance of monkeypox virus in Indonesia from 2023 to 2024.

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Epidemiology and Infection Pub Date : 2025-06-30 DOI:10.1017/S0950268825100253

Dhihram Tenrisau, Tri Bayu Purnama, Mulyanti Ayu Wulandari Maulana, Rizqy Fauzia Ahsani, Happy Kusuma Mulya, Yustinus Maladan, Listiana Azizah, Gerald Bagus A Caloh, Firdaus Kasim

{"title":"Molecular epidemiological surveillance of monkeypox virus in Indonesia from 2023 to 2024.","authors":"Dhihram Tenrisau, Tri Bayu Purnama, Mulyanti Ayu Wulandari Maulana, Rizqy Fauzia Ahsani, Happy Kusuma Mulya, Yustinus Maladan, Listiana Azizah, Gerald Bagus A Caloh, Firdaus Kasim","doi":"10.1017/S0950268825100253","DOIUrl":null,"url":null,"abstract":"<p><p>Monkeypox (mpox) has re-emerged as global public health concern including in several non-endemic countries. This study aims to characterize monkeypox virus (MPXV) genomes in Indonesia, to explore viral evolution and transmission. Genomic analysis was conducted on 53 isolates from Indonesian mpox patients between 2023 and 2024. All sequences belonged to Clade IIb, with identified sub-clades including A.1.1, B.1, B.1.3, and C.1 - of which C.1 became dominant during this period. Out of 87 mpox-confirmed cases, 60.9% (53/87) were successfully sequenced and submitted to the Global Initiative on Sharing All Influenza Data (GISAID). The majority of cases in Indonesia occurred among males (95.4%), men who have sex with men (59.8%), and people living with HIV/AIDS (71.3%). Notably, a large portion of cases had no travel history, suggesting local transmission. Initially, only clade IIb (B.1) was detected in October 2022. By August 2023, lineage diversity had increased, with B.1.3 and C.1 emerging as the predominant sub-clades. A time-calibrated phylogenetic tree revealed genetic relatedness and shared ancestry within clade IIb. Integrating genomic and epidemiological data offers valuable insights to improve mpox surveillance and public health response in Indonesia and the broader region.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e79"},"PeriodicalIF":2.5000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247005/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiology and Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0950268825100253","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Monkeypox (mpox) has re-emerged as global public health concern including in several non-endemic countries. This study aims to characterize monkeypox virus (MPXV) genomes in Indonesia, to explore viral evolution and transmission. Genomic analysis was conducted on 53 isolates from Indonesian mpox patients between 2023 and 2024. All sequences belonged to Clade IIb, with identified sub-clades including A.1.1, B.1, B.1.3, and C.1 - of which C.1 became dominant during this period. Out of 87 mpox-confirmed cases, 60.9% (53/87) were successfully sequenced and submitted to the Global Initiative on Sharing All Influenza Data (GISAID). The majority of cases in Indonesia occurred among males (95.4%), men who have sex with men (59.8%), and people living with HIV/AIDS (71.3%). Notably, a large portion of cases had no travel history, suggesting local transmission. Initially, only clade IIb (B.1) was detected in October 2022. By August 2023, lineage diversity had increased, with B.1.3 and C.1 emerging as the predominant sub-clades. A time-calibrated phylogenetic tree revealed genetic relatedness and shared ancestry within clade IIb. Integrating genomic and epidemiological data offers valuable insights to improve mpox surveillance and public health response in Indonesia and the broader region.

查看原文本刊更多论文

2023 - 2024年印度尼西亚猴痘病毒分子流行病学监测。

猴痘已重新成为全球公共卫生问题，包括在一些非流行国家。本研究旨在分析印度尼西亚猴痘病毒（MPXV）的基因组特征，探讨病毒的进化和传播。对2023年至2024年从印度尼西亚m痘患者分离的53株进行了基因组分析。所有序列均属于IIb支系，鉴定出的亚支系包括A.1.1、B.1、B.1.3和C.1 -，其中C.1支系在此时期占优势。在87例甲型h1n1流感确诊病例中，60.9%（53/87）成功测序并提交给共享所有流感数据全球倡议（GISAID）。印度尼西亚的大多数病例发生在男性（95.4%）、男男性行为者（59.8%）和艾滋病毒/艾滋病感染者（71.3%）中。值得注意的是，很大一部分病例没有旅行史，提示本地传播。最初，仅在2022年10月检测到进化枝IIb （B.1）。到2023年8月，谱系多样性有所增加，B.1.3和C.1成为优势亚枝。时间校准的系统发育树揭示了进化枝IIb的遗传亲缘关系和共同祖先。整合基因组和流行病学数据为改善印度尼西亚和更广泛区域的麻疹监测和公共卫生应对提供了宝贵的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Epidemiology and Infection 医学-传染病学

CiteScore

4.10

自引率

2.40%

发文量

366

审稿时长

3-6 weeks

期刊介绍： Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.