Binyam N Desta, Sara M Pires, Tine Hald, Tesfaye Gobena, Custodia Macuamule, Belisario Moiane, Olanrewaju E Fayemi, Christianah I Ayolabi, Gabriel Akanni, Blandina T Mmbaga, Kate M Thomas, Happiness Kumburu, Warren Dodd, Shannon E Majowicz
{"title":"The epidemiology of acute gastrointestinal illness in Ethiopia, Mozambique, Nigeria, and Tanzania: a population survey.","authors":"Binyam N Desta, Sara M Pires, Tine Hald, Tesfaye Gobena, Custodia Macuamule, Belisario Moiane, Olanrewaju E Fayemi, Christianah I Ayolabi, Gabriel Akanni, Blandina T Mmbaga, Kate M Thomas, Happiness Kumburu, Warren Dodd, Shannon E Majowicz","doi":"10.1017/S095026882500038X","DOIUrl":"https://doi.org/10.1017/S095026882500038X","url":null,"abstract":"<p><p>Gastrointestinal infections significantly impact African low- and middle-income countries, although, accurate data on acute gastrointestinal illness (AGI) for all ages are lacking. This study aimed to describe the epidemiology of AGI in Ethiopia, Mozambique, Nigeria, and Tanzania. A population survey was conducted in one urban and one rural site per country, from 01 October 2020 to 30 September 2021, using web-based and face-to-face tools (n = 4417). The survey tool was adapted from high-income countries, ensuring comparability through an internationally recommended AGI case definition. Ethiopia had the highest AGI incidence (0.87 episodes per person-year), followed by Mozambique (0.58), Tanzania (0.41), and Nigeria (0.34). Age-standardized incidence was highest in Mozambique (1.46) and Ethiopia (1.25), compared to Tanzania (0.58) and Nigeria (0.33). The 4-week prevalence was 6.4% in Ethiopia and 4.3% in Mozambique, compared to 3.1% in Tanzania and 2.6% in Nigeria. AGI lasted an average of 5.3 days in Ethiopia and 3.0 to 3.4 days elsewhere. Children under five had 4.4 times higher AGI odds (95% CI: 2.8, 6.7) than those aged 15-59. The study provides empirical data on the incidence and demographic determinants of AGI in these four countries.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"153 ","pages":"e63"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xi Chen, Jianbo Ba, Yuanhua Liu, Jiaqi Huang, Ke Li, Yun Yin, Jin Shi, Jiayao Xu, Rui Yuan, Michael P Ward, Wei Tu, Lili Yu, Quanyi Wang, Xiaoli Wang, Zhaorui Chang, Zhijie Zhang
{"title":"Spatiotemporal filtering modeling of hand, foot, and mouth disease: a case study from East China, 2009-2015.","authors":"Xi Chen, Jianbo Ba, Yuanhua Liu, Jiaqi Huang, Ke Li, Yun Yin, Jin Shi, Jiayao Xu, Rui Yuan, Michael P Ward, Wei Tu, Lili Yu, Quanyi Wang, Xiaoli Wang, Zhaorui Chang, Zhijie Zhang","doi":"10.1017/S0950268824001080","DOIUrl":"https://doi.org/10.1017/S0950268824001080","url":null,"abstract":"<p><p>Hand, foot, and mouth disease (HFMD) shows spatiotemporal heterogeneity in China. A spatiotemporal filtering model was constructed and applied to HFMD data to explore the underlying spatiotemporal structure of the disease and determine the impact of different spatiotemporal weight matrices on the results. HFMD cases and covariate data in East China were collected between 2009 and 2015. The different spatiotemporal weight matrices formed by Rook, K-nearest neighbour (KNN; <i>K</i> = 1), distance, and second-order spatial weight matrices (<i>SO-SWM</i>) with first-order temporal weight matrices in contemporaneous and lagged forms were decomposed, and spatiotemporal filtering model was constructed by selecting eigenvectors according to <i>MC</i> and the <i>AIC.</i> We used <i>MI</i>, standard deviation of the regression coefficients, and five indices (<i>AIC</i>, <i>BIC</i>, <i>DIC</i>, <i>R</i><sup>2</sup>, and <i>MSE</i>) to compare the spatiotemporal filtering model with a Bayesian spatiotemporal model. The eigenvectors effectively removed spatial correlation in the model residuals (Moran's <i>I</i> < 0.2, <i>p</i> > 0.05). The Bayesian spatiotemporal model's Rook weight matrix outperformed others. The spatiotemporal filtering model with <i>SO-SWM</i> was superior, as shown by lower <i>AIC</i> (92,029.60), <i>BIC</i> (92,681.20), and <i>MSE</i> (418,022.7) values, and higher <i>R</i><sup>2</sup> (0.56) value. All spatiotemporal contemporaneous structures outperformed the lagged structures. Additionally, eigenvector maps from the Rook and <i>SO-SWM</i> closely resembled incidence patterns of HFMD.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"153 ","pages":"e61"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanie Sterian, Thivya Naganathan, Tricia Corrin, Lisa Waddell
{"title":"Evidence on the associations and safety of COVID-19 vaccination and post COVID-19 condition: an updated living systematic review.","authors":"Melanie Sterian, Thivya Naganathan, Tricia Corrin, Lisa Waddell","doi":"10.1017/S0950268825000378","DOIUrl":"10.1017/S0950268825000378","url":null,"abstract":"<p><p>Post COVID-19 condition (PCC) refers to persistent symptoms occurring ≥12 weeks after COVID-19. This living systematic review (SR) assessed the impact of vaccination on PCC and vaccine safety among those with PCC, and was previously published with data up to December 2022. Searches were updated to 31 January 2024 and standard SR methodology was followed. Seventy-eight observational studies were included (47 new). There is moderate confidence that two doses pre-infection reduces the odds of PCC (pooled OR (pOR) 0.69, 95% CI 0.64-0.74, I<sup>2</sup> = 35.16%). There is low confidence for remaining outcomes of one dose and three or more doses. A booster dose may further reduce the odds of PCC compared to only a primary series (pOR 0.85, 95% CI 0.74-0.98, I<sup>2</sup> = 16.85%). Among children ≤18 years old, vaccination may not reduce the odds (pOR 0.79, 95% CI 0.56-1.11, I<sup>2</sup> = 37.2%) of PCC. One study suggests that vaccination within 12 weeks post-infection may reduce the odds of PCC. For those with PCC, vaccination appears safe (four studies) and may reduce the odds of PCC persistence (pOR 0.73, 95% CI 0.57-0.92, I<sup>2</sup> = 15.5%).</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e62"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elias A M Abucar, Mascha Kern, Tobias Kurth, Anne Meierkord, Maximilian Gertler, Joachim Seybold, Stefanie Theuring, Frank P Mockenhaupt
{"title":"Health-related quality of life up to 2 years after SARS-CoV-2 infection: a descriptive cohort study.","authors":"Elias A M Abucar, Mascha Kern, Tobias Kurth, Anne Meierkord, Maximilian Gertler, Joachim Seybold, Stefanie Theuring, Frank P Mockenhaupt","doi":"10.1017/S0950268825000366","DOIUrl":"10.1017/S0950268825000366","url":null,"abstract":"<p><p>Health-related quality of life (HRQoL) in the context of COVID-19 is not fully understood. We assessed HRQoL using Patient-Reported Outcomes Measurement Information System® measures among 559 former COVID-19 patients and 298 non-infected individuals. HRQoL was captured once up to 2 years after the initial test. Additionally, we described associations of characteristics with impaired HRQoL. Overall, HRQoL scores were inferior among former patients. A meaningful group difference of at least three T-score points was discernible until 12 months after testing for fatigue (3.1), sleep disturbance (3.5), and dyspnoea (3.7). Cognitive function demonstrated such difference even at >18 months post-infection (3.3). Following dichotomization, pronounced differences in impaired HRQoL were observed in physical (19.2% of former patients, 7.3% of non-infected) and cognitive function (37.6% of former patients, 16.5% of non-infected). Domains most commonly affected among former patients were depression (34.9%), fatigue (37.4%), and cognitive function. Factors that associated with HRQoL impairments among former patients included age (OR ≤2.1), lower education (OR ≤5.3), and COVID-19-related hospitalization (OR ≤4.7), among others. These data underline the need for continued attention of the scientific community to further investigate potential long-term health limitations after COVID-19 to ultimately establish adequate screening and management options for those affected.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e60"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophie L Campman, Anders Boyd, Janke Schinkel, Liza Coyer, Charles Agyemang, Henrike Galenkamp, Anitra D M Koopman, Felix P Chilunga, Jelle Koopsen, Aeilko H Zwinderman, Suzanne Jurriaans, Karien Stronks, Maria Prins
{"title":"SARS-CoV-2 infection and vaccination status in six ethnic groups in Amsterdam, The Netherlands, May to November 2022 - CORRIGENDUM.","authors":"Sophie L Campman, Anders Boyd, Janke Schinkel, Liza Coyer, Charles Agyemang, Henrike Galenkamp, Anitra D M Koopman, Felix P Chilunga, Jelle Koopsen, Aeilko H Zwinderman, Suzanne Jurriaans, Karien Stronks, Maria Prins","doi":"10.1017/S0950268825000342","DOIUrl":"10.1017/S0950268825000342","url":null,"abstract":"","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"153 ","pages":"e53"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth I Hazelhorst, Catharina E van Ewijk, Cornelia C H Wielders, Margreet J M Te Wierik, Susan J M Hahné, Hester E de Melker, Mirjam J Knol, Brechje de Gier
{"title":"Risk factors for invasive group A streptococcal infection in children aged 6 months to 5 years: a case-control study, the Netherlands, February-May 2023.","authors":"Elizabeth I Hazelhorst, Catharina E van Ewijk, Cornelia C H Wielders, Margreet J M Te Wierik, Susan J M Hahné, Hester E de Melker, Mirjam J Knol, Brechje de Gier","doi":"10.1017/S0950268825000275","DOIUrl":"10.1017/S0950268825000275","url":null,"abstract":"<p><p>In 2022, an increase in invasive group A streptococcal (iGAS) infections was observed in the Netherlands. A particular increase was seen among children; therefore, we aimed to assess risk factors for iGAS infection in children aged 6 months to 5 years. A prospective case-control study was conducted between February and May 2023. We approached parents of notified iGAS cases to complete a questionnaire on exposures during 4 weeks prior to disease onset. Controls were recruited via social media and matched to cases on sex and birthyear. Conditional logistic regression was performed to estimate odds ratios (OR) of exposures. For the analysis, we included 18 cases and 103 controls. Varicella prior to onset of iGAS disease was reported in two (11%) cases and one (1%) control (OR: 12.0, 95% CI: 1.1-139.0). Exposure to group A streptococcal (GAS)-like illnesses such as impetigo, pharyngitis, and scarlet fever was reported in 8 (44%) cases and 15 (15%) controls (OR: 7.1, 95% CI: 1.8-29.0). Our findings are in line with previous studies by identifying varicella as a risk factor for iGAS among young children and highlight the association with non-invasive GAS infections in the community as a possible source of transmission.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e57"},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Suomenrinne-Nordvik, Tuija Leino, Mikhail Shubin, Kari Auranen, Simopekka Vänskä
{"title":"Quantifying the direct and indirect components of COVID-19 vaccine effectiveness during the Delta variant era.","authors":"Anna Suomenrinne-Nordvik, Tuija Leino, Mikhail Shubin, Kari Auranen, Simopekka Vänskä","doi":"10.1017/S0950268825000354","DOIUrl":"10.1017/S0950268825000354","url":null,"abstract":"<p><p>The efficacy of COVID-19 vaccines against the Delta variant has been observed to be high, both against severe disease and infection. The full population level vaccine effectiveness, however, also contains the indirect effects of vaccination, which require analysis of transmission dynamics to uncover. Finland was close to naïve to SARS-CoV-2 infections before the Delta dominant era, and non-pharmaceutical interventions (NPIs) were at an internationally low level. We utilize Finnish register data and a mathematical model for transmission and COVID-19 disease burden to construct a completely unvaccinated control population and estimate the different components of the vaccine effectiveness. The estimated direct effectiveness was 72% against COVID-19 cases and 87-96% against severe disease outcomes, but the estimated indirect effectiveness was even better, 93% against cases and 94-97% against severe disease. The total and overall effectiveness, including both direct and indirect effects of vaccination, were thus excellent. Our results show how well the population was protected by vaccination during the Delta era, especially by the indirect effectiveness, providing protection also to the unvaccinated part of the population. The estimated averted numbers of hospitalizations, ICU admissions, and deaths in Finland during the Delta era under the implemented NPIs were about 100 times the observed numbers.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e59"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Can Chen, Dingmo Chen, Yuxia Du, Daixi Jiang, Kexin Cao, Mengya Yang, Xiaoyue Wu, Mengsha Chen, Wenkai Zhou, Jiaxing Qi, Yue You, Rui Yan, Shigui Yang
{"title":"Global patterns and trends in deaths of influenza-associated lower respiratory infections from 1990 to 2019.","authors":"Can Chen, Dingmo Chen, Yuxia Du, Daixi Jiang, Kexin Cao, Mengya Yang, Xiaoyue Wu, Mengsha Chen, Wenkai Zhou, Jiaxing Qi, Yue You, Rui Yan, Shigui Yang","doi":"10.1017/S0950268824001559","DOIUrl":"10.1017/S0950268824001559","url":null,"abstract":"<p><p>This study examined global trends in influenza-associated lower respiratory infections (LRIs) deaths from 1990 to 2019 using data from the GBD 2019. The annual percentage change (APC) and average annual percentage change (AAPC) were used to analyze age-standardized death rates (ASDR). Globally, the ASDR of influenza-associated LRIs was 3.29/100,000 in 2019, which was higher in the African region (6.57/100,000) and among adults aged 70 years and older (29.88/100,000). The ASDR of influenza-associated LRIs decreased significantly from 1990 to 2019 (AAPC = -1.88%, P < 0.05). However, it was significantly increased among adults aged 70 years and older during 2017-2019 (APC = 2.31%, P < 0.05), especially in Western Pacific Region and South-East Asia Regions. The ratio of death rates between adults aged 70 years and older and children aged under 5 years increased globally from 1.63 in 1990 to 5.34 in 2019, and the Western Pacific Region experienced the most substantial increase, with the ratio soaring from 1.83 in 1990 to 12.98 in 2019. Despite a decline in the global ASDR of influenza-associated LRIs, it continues to impose a significant burden, particularly in the African, Western Pacific regions and among the elderly population.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"153 ","pages":"e49"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yili Chen, Pingjuan Liu, Huayin Li, Wenxiang Huang, Chunxia Yang, Mei Kang, Xiaofeng Jiang, Bin Shan, Hong He, Fupin Hu, Pengcheng Li, Yingchun Xu, Kang Liao
{"title":"Antimicrobial susceptibility of gram-negative strains isolated from bloodstream infections in China: Results from the study for monitoring antimicrobial resistance trends (SMART) 2018-2020.","authors":"Yili Chen, Pingjuan Liu, Huayin Li, Wenxiang Huang, Chunxia Yang, Mei Kang, Xiaofeng Jiang, Bin Shan, Hong He, Fupin Hu, Pengcheng Li, Yingchun Xu, Kang Liao","doi":"10.1017/S0950268824001286","DOIUrl":"10.1017/S0950268824001286","url":null,"abstract":"<p><p>The study aims were to present in vitro susceptibilities of clinical isolates from Gram-negative bacteria bloodstream infections (GNBSI) collected in China. GNBSI isolates were collected from 18 tertiary hospitals in 7 regions of China from 2018 to 2020. Minimum inhibitory concentrations were assessed using a Trek Diagnostic System. Susceptibility was determined using CLSI broth microdilution, and breakpoints were interpreted using CLSI M100 (2021). A total of 1,815 GNBSI strains were collected, with <i>E. coli</i> (42.4%) and <i>Klebsiella pneumoniae</i> (28.6%) being the most prevalent species, followed by <i>P. aeruginosa</i> (6.7%). Susceptibility analyses revealed low susceptibilities (<40%) of ESBL-producing <i>E. coli</i> and <i>K. pneumonia</i> to third-/fourth-generation cephalosporins, monobactamases, and fluoroquinolones. High susceptibilities to colistin (95.0%) and amikacin (81.3%) were found for <i>K. pneumoniae</i>, while <i>Acinetobacter baumannii</i> exhibited a high susceptibility (99.2%) to colistin but a low susceptibility to other antimicrobials (<27.5%). Isolates from ICUs displayed lower drug susceptibility rates of <i>K. pneumoniae</i> and <i>A. baumannii</i> than isolates from non-ICUs (all <i>P</i> < 0.05). Carbapenem-resistant and ESBL-producing <i>K. pneumoniae</i> detection was different across regions (both <i>P</i> < 0.05). <i>E. coli</i> and <i>K. pneumoniae</i> were major contributors to GNBSI, while <i>A. baumannii</i> exhibited severe drug resistance in isolates obtained from ICU departments.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"153 ","pages":"e48"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeeva John, Sonia Smith, Clare Sawyer, Beth Brokenshire, Charlotte Anderson, David J Roberts
{"title":"Invasive group a streptococcal infection associated with community healthcare services delivered at home, South East England, December 2021-2023: Descriptive epidemiological study.","authors":"Jeeva John, Sonia Smith, Clare Sawyer, Beth Brokenshire, Charlotte Anderson, David J Roberts","doi":"10.1017/S0950268825000287","DOIUrl":"10.1017/S0950268825000287","url":null,"abstract":"<p><p>Invasive group A Streptococcal (iGAS) outbreaks have been linked to Community Healthcare Services Delivered at Home (CHSDH). There is, however, very limited evidence describing the epidemiology and mortality of iGAS cases associated with CHSDH. We used routine data to describe iGAS cases in adults who had received CHSDH prior to onset and compare characteristics between CHSDH-outbreak and non-outbreak CHSDH cases, in South East England between December 2021 and December 2023. There were 80/898 (8.9%) iGAS case episodes with CHSDH prior to onset; cases were in elderly people (50% aged 85 and over), and had primarily received wound or ulcer care (93.8%), with almost all care delivered by community nurses (98.8%). The 30-day all-cause case fatality was 26.3%. <i>Emm</i> 1.0 was the most common type (17.5%). In this period, 5/11 iGAS outbreaks (45.4%) were CHSDH-associated, and 25 cases with receipt of CHSDH prior to onset (31.3%, Confidence Interval [CI] 21.3-42.6%) were linked to these outbreaks. On univariate analysis, CHSDH-outbreak case episodes were more likely to be associated with <i>emm</i> pattern genotype E (OR 6.1 95% CI 1.8-20.9), and skin or soft tissue infection clinical presentation (OR 3.6, 95% CI 1.1-12.0) than non-outbreak CHSDH cases. There may be an increased risk of propagation of iGAS outbreaks in patients receiving CHSDH, emphasizing the need for rigorous early infection prevention and control, and outbreak surveillance.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e56"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}