Epidemiology and Infection最新文献_第2页

National epidemiology of culture-confirmed brucellosis in Israel, 2004-2022. 2004-2022 年以色列经培养确诊的布鲁氏菌病的全国流行病学。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-05-21 DOI: 10.1017/S0950268824000803

Miriam Weinberger, Jacob Moran-Gilad, Michal Perry Markovich, Svetlana Bardenstein

{"title":"National epidemiology of culture-confirmed brucellosis in Israel, 2004-2022.","authors":"Miriam Weinberger, Jacob Moran-Gilad, Michal Perry Markovich, Svetlana Bardenstein","doi":"10.1017/S0950268824000803","DOIUrl":"10.1017/S0950268824000803","url":null,"abstract":"Brucellosis, a global zoonosis, is endemic in Israel. We used a national database of culture-confirmed cases (2004-2022) to analyse the trends of brucellosis. Of 2,489 unique cases, 99.8% were bacteraemic, 64% involved males, and the mean age was 30.5 years. Brucella melitensis was the dominant species (99.6%). Most cases occurred among the Arab sector (84.9%) followed by the Jewish (8.5%) and Druze (5.5%) sectors. The average annual incidence rates overall and for the Arab, Druze, and Jewish sectors were 1.6/100,000, 6.6/100,000, 5.5/100,000, and 0.18/100,000, respectively. The annual incidence rates among the Arab (incidence rate ratio (IRR) = 36.4) and the Druze (IRR = 29.6) sectors were significantly higher than among the Jewish sector (p < 0.001). The highest incidence rates among the Arab sector occurred in the South District, peaking at 41.0/100,000 in 2012. The frequencies of B. melitensis isolated biotypes (biotype 1 - 69.1%, biotype 2 - 26.0%, and biotype 3 - 4.3%) differed from most Middle Eastern and European countries. A significant switch between the dominant biotypes was noted in the second half of the study period. Efforts for control and prevention should be sustained and guided by a One Health approach mindful of the differential trends and changing epidemiology.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Farm animal exposure setting impacts hemolytic uremic syndrome risk among Shiga toxin-producing Escherichia coli cases: Minnesota, 2010-2019. 农场动物暴露环境对感染产志贺毒素大肠杆菌病例中溶血性尿毒症风险的影响--明尼苏达州，2010-2019年。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-05-16 DOI: 10.1017/S0950268824000773

Madhura S Vachon, Joshua Rounds, Kirk Smith, Carlota Medus, Craig W Hedberg, Carrie Klumb, Gillian A M Tarr

{"title":"Farm animal exposure setting impacts hemolytic uremic syndrome risk among Shiga toxin-producing Escherichia coli cases: Minnesota, 2010-2019.","authors":"Madhura S Vachon, Joshua Rounds, Kirk Smith, Carlota Medus, Craig W Hedberg, Carrie Klumb, Gillian A M Tarr","doi":"10.1017/S0950268824000773","DOIUrl":"10.1017/S0950268824000773","url":null,"abstract":"Shiga toxin-producing Escherichia coli (STEC) transmission occurs in ruminant contact settings and can lead to post-diarrheal hemolytic uremic syndrome (HUS). We investigated whether exposure setting (ruminant exposure from living or working on a farm, visiting a farm or animal contact venue, or both) influenced HUS development among individuals with laboratory-confirmed STEC infections using Minnesota surveillance data from 2010 to 2019. Logistic regression was performed to determine whether exposure setting was associated with HUS independent of age, gender, stx2 gene detection, and county ruminants per capita. Among confirmed STEC cases, ruminant exposure only from living or working on a farm was not significantly associated with HUS compared to cases without any ruminant exposure (OR: 1.25; 95% CI: 0.51, 3.04). However, ruminant exposure only from visiting a farm or public animal contact venue was associated with HUS (OR: 2.53; 95% CI: 1.50, 4.24). Exposure from both settings was also associated with HUS (OR: 3.71; 95% CI: 1.39, 9.90). Exposure to ruminants when visiting farms or animal contact venues is an important predictor of HUS, even among people who live or work on farms with ruminants. All people, regardless of routine ruminant exposure, should take care in settings with ruminants to avoid infection with STEC.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the cause of a 2021 winter wave of COVID-19 in a border region in eastern Germany: a mixed-methods study, August to November 2021. 调查 2021 年德国东部边境地区 COVID-19 冬季流行的原因：一项混合方法研究，2021 年 8 月至 11 月。

IF 4.2 4区医学

Epidemiology and Infection Pub Date : 2024-05-16 DOI: 10.1017/S0950268824000761

Buqing Yi, Eva Patrasová, Lenka Šimůnková, Fabian Rost, Sylke Winkler, Alexa Laubner, Susanne Reinhardt, Andreas Dahl, Alexander H Dalpke

{"title":"Investigating the cause of a 2021 winter wave of COVID-19 in a border region in eastern Germany: a mixed-methods study, August to November 2021.","authors":"Buqing Yi, Eva Patrasová, Lenka Šimůnková, Fabian Rost, Sylke Winkler, Alexa Laubner, Susanne Reinhardt, Andreas Dahl, Alexander H Dalpke","doi":"10.1017/S0950268824000761","DOIUrl":"10.1017/S0950268824000761","url":null,"abstract":"It is so far unclear how the COVID-19 winter waves started and what should be done to prevent possible future waves. In this study, we deciphered the dynamic course of a winter wave in 2021 in Saxony, a state in Eastern Germany neighbouring the Czech Republic and Poland. The study was carried out through the integration of multiple virus genomic epidemiology approaches to track transmission chains, identify emerging variants and investigate dynamic changes in transmission clusters. For identified local variants of interest, functional evaluations were performed. Multiple long-lasting community transmission clusters have been identified acting as driving force for the winter wave 2021. Analysis of the dynamic courses of two representative clusters indicated a similar transmission pattern. However, the transmission cluster caused by a locally occurring new Delta variant AY.36.1 showed a distinct transmission pattern, and functional analyses revealed a replication advantage of it. This study indicated that long-lasting community transmission clusters starting since early autumn caused by imported or locally occurring variants all contributed to the development of the 2021 winter wave. The information we achieved might help future pandemic prevention.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial-temporal distribution characteristics of pulmonary tuberculosis in eastern China from 2011 to 2021. 2011-2021年中国东部地区肺结核的时空分布特征。

IF 4.2 4区医学

Epidemiology and Infection Pub Date : 2024-05-15 DOI: 10.1017/S0950268824000785

Ke Chen, Liang Cheng, Hao Yu, Yong Zhou, Limei Zhu, Zhongqi Li, Tenglong Li, Leonardo Martinez, Qiao Liu, Bei Wang

{"title":"Spatial-temporal distribution characteristics of pulmonary tuberculosis in eastern China from 2011 to 2021.","authors":"Ke Chen, Liang Cheng, Hao Yu, Yong Zhou, Limei Zhu, Zhongqi Li, Tenglong Li, Leonardo Martinez, Qiao Liu, Bei Wang","doi":"10.1017/S0950268824000785","DOIUrl":"10.1017/S0950268824000785","url":null,"abstract":"China is still among the 30 high-burden tuberculosis (TB) countries in the world. Few studies have described the spatial epidemiological characteristics of pulmonary TB (PTB) in Jiangsu Province. The registered incidence data of PTB patients in 95 counties of Jiangsu Province from 2011 to 2021 were collected from the Tuberculosis Management Information System. Three-dimensional spatial trends, spatial autocorrelation, and spatial-temporal scan analysis were conducted to explore the spatial clustering pattern of PTB. From 2011 to 2021, a total of 347,495 newly diagnosed PTB cases were registered. The registered incidence rate of PTB decreased from 49.78/100,000 in 2011 to 26.49/100,000 in 2021, exhibiting a steady downward trend (χ2 = 414.22, P < 0.001). The average annual registered incidence rate of PTB was higher in the central and northern regions. Moran's I indices of the registered incidence of PTB were all >0 (P< 0.05) except in 2016, indicating a positive spatial correlation overall. Local autocorrelation analysis showed that 'high-high' clusters were mainly distributed in northern Jiangsu, and 'low-low' clusters were mainly concentrated in southern Jiangsu. The results of this study assist in identifying settings and locations of high TB risk and inform policy-making for PTB control and prevention.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme mortality during a historical measles outbreak on Rotuma is consistent with measles immunosuppression. 罗图马岛历史上爆发麻疹疫情期间的高死亡率与麻疹免疫抑制是一致的。

IF 4.2 4区医学

Epidemiology and Infection Pub Date : 2024-05-13 DOI: 10.1017/S095026882400075X

Susie Cant, G Dennis Shanks, Matt J Keeling, Bridget S Penman

{"title":"Extreme mortality during a historical measles outbreak on Rotuma is consistent with measles immunosuppression.","authors":"Susie Cant, G Dennis Shanks, Matt J Keeling, Bridget S Penman","doi":"10.1017/S095026882400075X","DOIUrl":"10.1017/S095026882400075X","url":null,"abstract":"Until the early twentieth century, populations on many Pacific Islands had never experienced measles. As travel to the Pacific Islands by Europeans became more common, the arrival of measles and other pathogens had devastating consequences. In 1911, Rotuma in Fiji was hit by a measles epidemic, which killed 13% of the island population. Detailed records show two mortality peaks, with individuals reported as dying solely from measles in the first and from measles and diarrhoea in the second. Measles is known to disrupt immune system function. Here, we investigate whether the pattern of mortality on Rotuma in 1911 was a consequence of the immunosuppressive effects of measles. We use a compartmental model to simulate measles infection and immunosuppression. Whilst immunosuppressed, we assume that individuals are vulnerable to dysfunctional reactions triggered by either (i) a newly introduced infectious agent arriving at the same time as measles or (ii) microbes already present in the population in a pre-existing equilibrium state. We show that both forms of the immunosuppression model provide a plausible fit to the data and that the inclusion of immunosuppression in the model leads to more realistic estimates of measles epidemiological parameters than when immunosuppression is not included.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Varicella zoster virus outbreak in a long-term care unit of a tertiary care hospital in northern India. 印度北部一家三级医院的长期护理病房爆发水痘带状疱疹病毒。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-05-13 DOI: 10.1017/S0950268824000712

Rushika Saksena, Bonnie J Thomas, Ruma Das, Sunita Nagpal, Prem R Suri, Ranjan K Wadhwa, Aashish Choudhary, Rajni Gaind, Ekta Gupta

{"title":"Varicella zoster virus outbreak in a long-term care unit of a tertiary care hospital in northern India.","authors":"Rushika Saksena, Bonnie J Thomas, Ruma Das, Sunita Nagpal, Prem R Suri, Ranjan K Wadhwa, Aashish Choudhary, Rajni Gaind, Ekta Gupta","doi":"10.1017/S0950268824000712","DOIUrl":"10.1017/S0950268824000712","url":null,"abstract":"Nosocomial outbreak of varicella zoster virus (VZV) has been reported when susceptible individuals encounter a case of chicken pox or shingles. A suspected VZV outbreak was investigated in a 50-bedded in-patient facility of Physical Medicine and Rehabilitation in a tertiary care multispecialty hospital. A 30-year-old female patient admitted with Pott's spine was clinically diagnosed with chicken pox on 31 December 2022. The following week, four more cases were identified in the same ward. All cases were diagnosed as laboratory-confirmed varicella zoster infection by PCR. Primary case was a housekeeping staff who was clinically diagnosed with chicken pox 3 weeks prior (9 December 2022). He returned to work on eighth day of infection (17 December 2022) after apparent clinical recovery but before the lesions had crusted over. Thirty-one HCWs were identified as contacts a and three had no evidence of immunity. Two of these susceptible HCWs had onset of chickenpox shortly after first dose of VZV vaccination was inoculated. All cases recovered after treatment with no reported complications. VZV infection is highly contagious in healthcare settings with susceptible populations. Prompt identification of cases and implementation of infection prevention and control measures like patient isolation and vaccination are essential for the containment of outbreaks.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salmonella Hadar linked to two distinct transmission vehicles highlights challenges to enteric disease outbreak investigations. 哈达沙门氏菌与两种不同的传播途径有关，凸显了肠道疾病爆发调查所面临的挑战。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-05-13 DOI: 10.1017/S0950268824000682

Joshua M Brandenburg, Gregory Sean Stapleton, Kelly E Kline, Jennifer Khoury, Krystle Mallory, Kimberly D Machesky, Stephen G Ladd-Wilson, Ryan Scholz, Jennifer Freiman, Colin Schwensohn, Alexandra Palacios, Laura Gieraltowski, Zachary Ellison, Beth Tolar, Hattie E Webb, Kaitlin A Tagg, Zainab Salah, Megin Nichols

{"title":"Salmonella Hadar linked to two distinct transmission vehicles highlights challenges to enteric disease outbreak investigations.","authors":"Joshua M Brandenburg, Gregory Sean Stapleton, Kelly E Kline, Jennifer Khoury, Krystle Mallory, Kimberly D Machesky, Stephen G Ladd-Wilson, Ryan Scholz, Jennifer Freiman, Colin Schwensohn, Alexandra Palacios, Laura Gieraltowski, Zachary Ellison, Beth Tolar, Hattie E Webb, Kaitlin A Tagg, Zainab Salah, Megin Nichols","doi":"10.1017/S0950268824000682","DOIUrl":"10.1017/S0950268824000682","url":null,"abstract":"In 2020, an outbreak of Salmonella Hadar illnesses was linked to contact with non-commercial, privately owned (backyard) poultry including live chickens, turkeys, and ducks, resulting in 848 illnesses. From late 2020 to 2021, this Salmonella Hadar strain caused an outbreak that was linked to ground turkey consumption. Core genome multilocus sequence typing (cgMLST) analysis determined that the Salmonella Hadar isolates detected during the outbreak linked to backyard poultry and the outbreak linked to ground turkey were closely related genetically (within 0-16 alleles). Epidemiological and traceback investigations were unable to determine how Salmonella Hadar detected in backyard poultry and ground turkey were linked, despite this genetic relatedness. Enhanced molecular characterization methods, such as analysis of the pangenome of Salmonella isolates, might be necessary to understand the relationship between these two outbreaks. Similarly, enhanced data collection during outbreak investigations and further research could potentially aid in determining whether these transmission vehicles are truly linked by a common source and what reservoirs exist across the poultry industries that allow Salmonella Hadar to persist. Further work combining epidemiological data collection, more detailed traceback information, and genomic analysis tools will be important for monitoring and investigating future enteric disease outbreaks.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of respiratory syncytial virus in hospitalized children before, during, and after the COVID-19 lockdown restriction measures in Greece. 希腊 COVID-19 封锁限制措施之前、期间和之后住院儿童的呼吸道合胞病毒流行病学。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2024-05-13 DOI: 10.1017/S0950268824000724

Maria M Berikopoulou, Nick Dessypris, Elena Kalogera, Evangelia Petridou, Vasiliki Benetou, Levantia D Zahariadou, Tania Siahanidou, Athanasios Michos

{"title":"Epidemiology of respiratory syncytial virus in hospitalized children before, during, and after the COVID-19 lockdown restriction measures in Greece.","authors":"Maria M Berikopoulou, Nick Dessypris, Elena Kalogera, Evangelia Petridou, Vasiliki Benetou, Levantia D Zahariadou, Tania Siahanidou, Athanasios Michos","doi":"10.1017/S0950268824000724","DOIUrl":"10.1017/S0950268824000724","url":null,"abstract":"The COVID-19 pandemic modified the epidemiology and the transmission of respiratory syncytial virus (RSV). We collected data on RSV positivity and incidence from children hospitalized in the largest tertiary paediatric hospital in Greece before (2018-2020, period A), during (2020-2021, period B), and after (2021-2023, period C) the COVID-19 lockdown. A total of 9,508 children were tested for RSV. RSV positivity (%) was 17.6% (552/3,134) for period A, 2.1% (13/629) for period B, and 13.4% (772/5,745) for period C (p < 0.001). The mean age (±SD) of RSV-positive children among the three periods was A: 5.9(±9.3), B: 13.6 (±25.3), and C: 16.7 (±28.6) months (p < 0.001). The peak of RSV epidemiology was shifted from January-March (period A) to October-December (period C). RSV in-hospital incidence per 1,000 hospitalizations in paediatric departments was A:16.7, B:1.0, and C:28.1 (p < 0.001), and the incidence in the intensive care unit was A: 17.3, B: 0.6, and C: 26.6 (p < 0.001). A decrease in RSV incidence was observed during the COVID-19 lockdown period, whereas a significant increase was observed after the lockdown. A change in epidemiological patterns was identified after the end of the lockdown, with an earlier seasonal peak and an age shift of increased RSV incidence in older children.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High all-cause mortality and increasing proportion of older adults with tuberculosis in Texas, 2008-2020. 2008-2020 年得克萨斯州全因死亡率高，患肺结核的老年人比例增加。

IF 4.2 4区医学

Epidemiology and Infection Pub Date : 2024-05-13 DOI: 10.1017/S0950268824000669

Belinda A Medrano, Miryoung Lee, Gretchen Gemeinhardt, Lana Yamba, Blanca I Restrepo

{"title":"High all-cause mortality and increasing proportion of older adults with tuberculosis in Texas, 2008-2020.","authors":"Belinda A Medrano, Miryoung Lee, Gretchen Gemeinhardt, Lana Yamba, Blanca I Restrepo","doi":"10.1017/S0950268824000669","DOIUrl":"10.1017/S0950268824000669","url":null,"abstract":"Pulmonary tuberculosis (PTB) elimination efforts must consider the global growth of the ageing population. Here we used TB surveillance data from Texas, United States (2008-2020; total n = 10656) to identify unique characteristics and outcomes in older adults (OA, ≥65 years) with PTB, compared to young adults (YA, 18-39 years) or middle-aged adults (40-64 years). We found that the proportion of OA with PTB increased from 15% in 2008 to 24% in 2020 (trend p < 0.05). Diabetes was highly prevalent in OA (32%) but not associated with adverse outcomes. Death was 13-fold higher in OA compared to YA and was 7% at the time of diagnosis which suggests diagnostic delays. However, once TB was suspected, we found no differences in culture, smear, or nucleic acid detection of mycobacteria (although less lung cavitations) in OA. During treatment, OA had less drug-resistant TB, few adverse reactions and adhered with TB treatment. We recommend training healthcare workers to 'think TB' in OA, for prompt treatment initiation to diminish deaths. Furthermore, OA should be added as a priority group to the latent TB treatment guidelines by the World Health Organization, to prevent TB disease in this highly vulnerable group.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of SARS-CoV-2 variants and other respiratory infections: evidence from the Virus Watch prospective cohort in England. SARS-CoV-2 变体和其他呼吸道感染的长期结果：来自英格兰病毒观察前瞻性队列的证据。

IF 4.2 4区医学

Epidemiology and Infection Pub Date : 2024-05-10 DOI: 10.1017/S0950268824000748

Sarah Beale, Alexei Yavlinsky, Wing L E Fong, Vincent G Nguyen, Jana Kovar, Theo Vos, Sarah Wulf Hanson, Andrew C Hayward, Ibrahim Abubakar, Robert W Aldridge

{"title":"Long-term outcomes of SARS-CoV-2 variants and other respiratory infections: evidence from the Virus Watch prospective cohort in England.","authors":"Sarah Beale, Alexei Yavlinsky, Wing L E Fong, Vincent G Nguyen, Jana Kovar, Theo Vos, Sarah Wulf Hanson, Andrew C Hayward, Ibrahim Abubakar, Robert W Aldridge","doi":"10.1017/S0950268824000748","DOIUrl":"10.1017/S0950268824000748","url":null,"abstract":"This study compared the likelihood of long-term sequelae following infection with SARS-CoV-2 variants, other acute respiratory infections (ARIs) and non-infected individuals. Participants (n=5,630) were drawn from Virus Watch, a prospective community cohort investigating SARS-CoV-2 epidemiology in England. Using logistic regression, we compared predicted probabilities of developing long-term symptoms (>2 months) during different variant dominance periods according to infection status (SARS-CoV-2, other ARI, or no infection), adjusting for confounding by demographic and clinical factors and vaccination status. SARS-CoV-2 infection during early variant periods up to Omicron BA.1 was associated with greater probability of long-term sequalae (adjusted predicted probability (PP) range 0.27, 95% CI = 0.22-0.33 to 0.34, 95% CI = 0.25-0.43) compared with later Omicron sub-variants (PP range 0.11, 95% CI 0.08-0.15 to 0.14, 95% CI 0.10-0.18). While differences between SARS-CoV-2 and other ARIs (PP range 0.08, 95% CI 0.04-0.11 to 0.23, 95% CI 0.18-0.28) varied by period, all post-infection estimates substantially exceeded those for non-infected participants (PP range 0.01, 95% CI 0.00, 0.02 to 0.03, 95% CI 0.01-0.06). Variant was an important predictor of SARS-CoV-2 post-infection sequalae, with recent Omicron sub-variants demonstrating similar probabilities to other contemporaneous ARIs. Further aetiological investigation including between-pathogen comparison is recommended.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0