Epidemiology and Infection最新文献_第10页

The yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study. 巴西圣保罗地区结核病接触者调查：一项基于社区的横断面研究。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-30 DOI: 10.1017/S0950268824001675

José Mário Nunes da Silva, Fredi Alexander Diaz-Quijano

{"title":"The yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study.","authors":"José Mário Nunes da Silva, Fredi Alexander Diaz-Quijano","doi":"10.1017/S0950268824001675","DOIUrl":"10.1017/S0950268824001675","url":null,"abstract":"The strategy of tuberculosis (TB) contact investigation is essential for enhancing disease detection. We conducted a cross-sectional study to evaluate the yield of contact investigation for new TB cases, estimate the prevalence of TB, and identify characteristics of index cases associated with infection among contacts of new cases notified between 2010 and 2020 in São Paulo, Brazil. Out of 186466 index TB cases, 131055 (70.3%) underwent contact investigation. A total of 652286 contacts were screened, of which 451704 (69.2%) were examined. Of these, 12243 were diagnosed with active TB (yield of 1.9%), resulting in a number needed to screen of 53 and a number needed to test of 37 to identify one new TB case. The weighted prevalence for the total contacts screened was 2.8% (95% confidence interval [CI]: 2.7%-2.9%), suggesting underreporting of 6021 (95% CI: 5269-6673) cases. The likelihood of TB diagnosis was higher among contacts of cases identified through active case-finding, abnormal chest X-ray, pulmonary TB, or drug resistance, as well as among children, adults, women, individuals in socially vulnerable situations, and those with underlying clinical conditions. The study highlights significant TB underreporting among contacts, recommending strengthened contact investigation to promptly identify and treat new cases.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"153 ","pages":"e20"},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance and functional assessment of the Kimera P-IV point-of-care plasmonic qPCR prototype for ultra rapid pathogen detection of chlamydia trachomatis. 超快速检测沙眼衣原体的Kimera P-IV即时等离子qPCR原型的性能和功能评估。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-30 DOI: 10.1017/S0950268825000081

Joshua Hayes, Seung Soo Lee, Jason Carnevale, Daniel Shamir, Marc Bohbot, Andrew G Kirk, Miltiadis Paliouras, Mark A Trifiro

{"title":"Performance and functional assessment of the Kimera P-IV point-of-care plasmonic qPCR prototype for ultra rapid pathogen detection of chlamydia trachomatis.","authors":"Joshua Hayes, Seung Soo Lee, Jason Carnevale, Daniel Shamir, Marc Bohbot, Andrew G Kirk, Miltiadis Paliouras, Mark A Trifiro","doi":"10.1017/S0950268825000081","DOIUrl":"10.1017/S0950268825000081","url":null,"abstract":"Current standard microbiological techniques are generally very time consuming, usually requiring 24-72 h to establish a diagnosis. Consequentially, contemporary clinical practices implement broad-spectrum antibiotic administration prior to pathogen detection, prompting the emergence of extremely dangerous antibiotic-resistant bacteria. Additionally, lengthy test-to-result turnover times can greatly exacerbate the rate of disease spread. Rapid point-of-care (POC) diagnostics has quickly gained importance since the SARS-CoV-2 pandemic; accordingly, we have developed a rapid four-channel POC plasmonic quantitative polymerase chain reaction (qPCR) machine (Kimera P-IV) to respond to the deficiencies in infection control. Utilizing gold nanorods (GNRs) as nano-heaters and integrating vertical cavity surface emitting lasers (VCSEL) to replace traditional Peltier blocks, the Kimera P-IV has also incorporated quantitative real-time fluorescent monitoring. Using Chlamydia trachomatis genetic material to evaluate the rapid thermocycling performance of the platform, we have generated positive amplicons in less than 13 min; however, to achieve these results, several biological reagent considerations needed to be taken into account, specifically primer design. The device can achieve a limit of detection (LoD) of <101 DNA copies, a PCR efficiency of 88.3%, and can differentiate positive from negative results with 100% accuracy. Moreover, it can also analyze C. trachomatis DNA spiked urine samples via a simple dilution, suggesting that a separate nucleic acid step may not be needed for diagnosing infections. In conclusion, the operation of the Kimera P-IV prototype places it in a unique position of POC devices to revolutionize infectious disease diagnosis.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e27"},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective study of peripartum group B streptococcus colonization in Japanese mothers and neonates - ERRATUM. 日本母亲和新生儿围产期B组链球菌定植的前瞻性研究-勘误。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-27 DOI: 10.1017/S0950268825000020

Emiko Yoshida, Jun Takeda, Yojiro Maruyama, Naoko Suga, Satoru Takeda, Hajime Arai, Atsuo Itakura, Shintaro Makino

引用次数: 0

Risk factors associated with IgG seropersistence to Chlamydia trachomatis and Mycoplasma genitalium. 与沙眼衣原体和生殖支原体IgG血清持久性相关的危险因素。

IF 2.2 4区医学

Epidemiology and Infection Pub Date : 2025-01-24 DOI: 10.1017/S095026882500007X

Nea Koskela, Julia Butt, Birgitta E Michels, Kari Syrjänen, Seija Grenman, Tim Waterboer, Stina Syrjänen, Karolina Louvanto

{"title":"Risk factors associated with IgG seropersistence to Chlamydia trachomatis and Mycoplasma genitalium.","authors":"Nea Koskela, Julia Butt, Birgitta E Michels, Kari Syrjänen, Seija Grenman, Tim Waterboer, Stina Syrjänen, Karolina Louvanto","doi":"10.1017/S095026882500007X","DOIUrl":"10.1017/S095026882500007X","url":null,"abstract":"Sexually transmitted infections caused by Chlamydia trachomatis (Ct) and Mycoplasma genitalium (Mg) have significant implications both at the individual and societal levels. Our study evaluated various co-factors associated with persistent serum IgG-antibodies to Ct and Mg. Three hundred and twenty nine pregnant women and 135 men from the Finnish Family HPV study were analyzed for serum IgG-antibodies of pGP3 for Ct and MgPa and rMgPa for Mg using multiplex serology. Seropersistence to both Ct and Mg was more common in women (30.4% and 13.3%) than in men (17.4% and 5.3%). The number of lifetime sexual partners above 10, the practice of anal sex, and a history of diagnosed Ct were associated with seropersistence to Ct in women, adjusted ORs 5.6 (95%CI 1.39-22.29), 15.3 (95%CI 1.18-197.12) and 18.0 (95%CI 5.59-57.92), respectively. The increasing number of partners before the age of 20 was the main risk factor for seropersistence among women with Mg, adjusted OR range from 5.0 to 12.3 (95%CI range 1.17-100.90) and in men only with 6-10 partners for Ct, adjusted OR 12.6 (95%CI 1.55-102.49). To conclude, persistent Ct antibodies were associated with various sexual activities, and Mg seropositivity was mainly associated with increased sexual activity in early adulthood.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e104"},"PeriodicalIF":2.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lyme borreliosis awareness and risk perception: a survey in 20 European countries. 莱姆病的认识和风险认知——一项对20个欧洲国家的调查。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-23 DOI: 10.1017/S0950268825000068

L Hannah Gould, Emily Colby, Andreas Pilz, Gordon Brestrich, Kate Halsby, Patrick H Kelly, Jennifer C Moisi, James H Stark

引用次数: 0

SARS-CoV-2 infection and vaccination status in six ethnic groups in Amsterdam, The Netherlands, May to November 2022. 2022年5 - 11月荷兰阿姆斯特丹6个民族SARS-CoV-2感染和疫苗接种状况

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-23 DOI: 10.1017/S0950268825000056

Sophie L Campman, Anders Boyd, Janke Schinkel, Liza Coyer, Charles Agyemang, Henrike Galenkamp, Anitra D M Koopman, Felix P Chilunga, Jelle Koopsen, Aeilko H Zwinderman, Suzanne Jurriaans, Karien Stronks, Maria Prins

{"title":"SARS-CoV-2 infection and vaccination status in six ethnic groups in Amsterdam, The Netherlands, May to November 2022.","authors":"Sophie L Campman, Anders Boyd, Janke Schinkel, Liza Coyer, Charles Agyemang, Henrike Galenkamp, Anitra D M Koopman, Felix P Chilunga, Jelle Koopsen, Aeilko H Zwinderman, Suzanne Jurriaans, Karien Stronks, Maria Prins","doi":"10.1017/S0950268825000056","DOIUrl":"10.1017/S0950268825000056","url":null,"abstract":"We studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination status among six ethnic groups in Amsterdam, the Netherlands. We analysed participants of the Healthy Life in an Urban Setting cohort who were tested for SARS-CoV-2 spike protein antibodies between 17 May and 21 November 2022. We categorized participants with antibodies as only infected, only vaccinated (≥1 dose), or both infected and vaccinated, based on self-reported prior infection and vaccination status and previous seroprevalence data. We compared infection and vaccination status between ethnic groups using multivariable, multinomial logistic regression. Of the 1,482 included participants, 98.5% had SARS-CoV-2 antibodies (P between ethnic groups = 0.899). Being previously infected and vaccinated ranged from 41.5% (95% confidence interval (CI) = 35.0-47.9%) in the African Surinamese to 67.1% (95% CI = 59.1-75.0%) in the Turkish group. Compared to participants of Dutch origin, participants of South-Asian Surinamese (adjusted odds ratio (aOR) = 3.31, 95% CI = 1.50-7.31)), African Surinamese (aOR = 10.41, 95% CI = 5.17-20.94), Turkish (aOR = 3.74, 95% CI = 1.52-9.20), or Moroccan (aOR = 15.24, 95% CI = 6.70-34.65) origin were more likely to be only infected than infected and vaccinated, after adjusting for age, sex, household size, trust in the government's response to the pandemic, and month of study visit. SARS-CoV-2 infection and vaccination status varied across ethnic groups, particularly regarding non-vaccination. As hybrid immunity is most protective against coronavirus disease 2019, future vaccination campaigns should encourage vaccination uptake in specific demographic groups with only infection.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e23"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An outbreak of Shiga toxin-producing Escherichia coli serotype O103:H2 associated with unpasteurized soft cheese, England and Wales, 2022. 产志贺毒素的大肠杆菌血清型O103:H2与未经巴氏消毒的软奶酪有关，英格兰和威尔士，2022年。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-22 DOI: 10.1017/S0950268824001523

Ellen Heinsbroek, Eleanor Blakey, Alex Simpson, Neville Q Verlander, David R Greig, Frieda Jorgensen, Andrew Nelson, Amy Douglas, Sooria Balasegaram, Claire Jenkins, Richard Elson

{"title":"An outbreak of Shiga toxin-producing Escherichia coli serotype O103:H2 associated with unpasteurized soft cheese, England and Wales, 2022.","authors":"Ellen Heinsbroek, Eleanor Blakey, Alex Simpson, Neville Q Verlander, David R Greig, Frieda Jorgensen, Andrew Nelson, Amy Douglas, Sooria Balasegaram, Claire Jenkins, Richard Elson","doi":"10.1017/S0950268824001523","DOIUrl":"10.1017/S0950268824001523","url":null,"abstract":"In July 2022, a genetically linked and geographically dispersed cluster of 12 cases of Shiga toxin-producing Escherichia coli (STEC) O103:H2 was detected by the UK Health Security Agency using whole genome sequencing. Review of food history questionnaires identified cheese (particularly an unpasteurized brie-style cheese) and mixed salad leaves as potential vehicles. A case-control study was conducted to investigate exposure to these products. Case food history information was collected by telephone. Controls were recruited using a market research panel and self-completed an online questionnaire. Univariable and multivariable analyses were undertaken using Firth Logistic Regression. Eleven cases and 24 controls were included in the analysis. Consumption of the brie-style cheese of interest was associated with illness (OR 57.5, 95% confidence interval: 3.10-1,060). Concurrently, the production of the brie-style cheese was investigated. Microbiological sample results for the cheese products and implicated dairy herd did not identify the outbreak strain, but did identify the presence of stx genes and STEC, respectively. Together, epidemiological, microbiological, and environmental investigations provided evidence that the brie-style cheese was the vehicle for this outbreak. Production of unpasteurized dairy products was suspended by the business operator, and a review of practices was performed.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e172"},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular detection and typing of pathogenic Leptospira species from livestock and small mammals in Uganda. 乌干达家畜和小型哺乳动物致病性钩端螺旋体的分子检测和分型。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-22 DOI: 10.1017/S0950268825000044

Lordrick Alinaitwe, Martin Wainaina, Salome Dürr, Clovice Kankya, Velma Kivali, James Bugeza, Christopher Joshua Aturinda, Ashiraf Lubega, Anne Mayer-Scholl, Jolly Justine Hoona, Peter Bahn, Jens Andre Hammerl, Kristina Roesel, Elizabeth Anne Jessie Cook, Martin H Richter

{"title":"Molecular detection and typing of pathogenic Leptospira species from livestock and small mammals in Uganda.","authors":"Lordrick Alinaitwe, Martin Wainaina, Salome Dürr, Clovice Kankya, Velma Kivali, James Bugeza, Christopher Joshua Aturinda, Ashiraf Lubega, Anne Mayer-Scholl, Jolly Justine Hoona, Peter Bahn, Jens Andre Hammerl, Kristina Roesel, Elizabeth Anne Jessie Cook, Martin H Richter","doi":"10.1017/S0950268825000044","DOIUrl":"10.1017/S0950268825000044","url":null,"abstract":"Leptospira are bacteria that cause leptospirosis in both humans and animals. Human Leptospira infections in Uganda are suspected to arise from animal-human interactions. From a nationwide survey to determine Leptospira prevalence and circulating sequence types in Uganda, we tested 2030 livestock kidney samples, and 117 small mammals (rodents and shrews) using real-time PCR targeting the lipL32 gene. Pathogenic Leptospira species were detected in 45 livestock samples but not in the small mammals. The prevalence was 6.12% in sheep, 4.25% in cattle, 2.08% in goats, and 0.46% in pigs. Sequence typing revealed that Leptospira borgpetersenii, Leptospira kirschneri, and Leptospira interrogans are widespread across Uganda, with 13 novel sequence types identified. These findings enhance the East African MLST database and support the hypothesis that domesticated animals may be a source of human leptospirosis in Uganda, highlighting the need for increased awareness among those in close contact with livestock.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e50"},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and osteoarticular involvement sites' characteristics of multiple osteoarticular tuberculosis: a scoping review. 多发性骨关节结核的流行病学和骨关节受累部位特征：一个范围综述。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-21 DOI: 10.1017/S095026882400150X

Jian Zhou, Xuanjie Yang, Yong Hu, Shijun Li

{"title":"Epidemiological and osteoarticular involvement sites' characteristics of multiple osteoarticular tuberculosis: a scoping review.","authors":"Jian Zhou, Xuanjie Yang, Yong Hu, Shijun Li","doi":"10.1017/S095026882400150X","DOIUrl":"10.1017/S095026882400150X","url":null,"abstract":"Multiple osteoarticular tuberculosis (MOT) represents an uncommon yet severe form of tuberculosis, characterized by a lack of systematic analysis and comprehension. Our objective was to delineate MOT's epidemiological characteristics and establish a scientific foundation for prevention and treatment. We conducted searches across eight databases to identify relevant articles. Pearson's chi-square test (Fisher's exact test) and Bonferroni method were employed to assess osteoarticular involvement among patients of varying age and gender (α = 0.05). The study comprised 98 articles, encompassing 151 cases from 22 countries, with China and India collectively contributing 67.55% of cases. MOT predominantly affected individuals aged 0-30 years (58.94%). Pulmonary tuberculosis was evident in 16.55% of cases, with spinal involvement prevalent (57.62%). Significant differences were noted in trunk, spine, thoracic, and lumbar vertebrae involvement, as well as type I lesions across age groups, increasing with age. Moreover, significant differences were observed in upper limb bone involvement and type II lesions across age groups, decreasing with age. Gender differences were not significant. MOT primarily manifests in China and India, predominantly among younger individuals, indicating age-related variations in osteoarticular involvement. Enhanced clinical awareness is crucial for accurate MOT diagnosis, mitigating missed diagnoses and misdiagnoses.","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e26"},"PeriodicalIF":2.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Queensland JEV vaccine program response to the 2022 Australian outbreak - CORRIGENDUM. 对昆士兰州乙脑病毒疫苗计划应对2022年澳大利亚疫情的评估-勘误表。

IF 2.5 4区医学

Epidemiology and Infection Pub Date : 2025-01-17 DOI: 10.1017/S0950268825000019

Angus Misan, Stephen B Lambert, Hai Phung, Megan K Young

引用次数: 0