{"title":"Loquat and its phytochemical potential: A promising application in food technology","authors":"Vishal Kumar, Prerna Gupta, Mukul Kumar","doi":"10.1002/efd2.158","DOIUrl":"https://doi.org/10.1002/efd2.158","url":null,"abstract":"<p>This review study highlights the importance of loquat (<i>Eriobotrya japonica</i> Lindl.) in terms of its nutritional, pharmaceutical, and nutraceutical value. The entire plant, including its seeds, leaves, flowers, fruits, and peel, contains a wide range of bioactive compounds, such as phenolics, carotenoids, triterpenic acids, and organic acids. These compounds exhibit a wide range of beneficial properties such as fighting cancer, reducing inflammation, managing diabetes, combating viruses, preventing mutations, inhibiting nitrosamine formation, killing harmful microorganisms, lowering blood sugar levels, inducing cell death, and protecting the liver. The extraction and separation of such compounds will greatly enhance and expand its potential. Furthermore, the waste generated from the seeds and peel can be effectively used for submerged and solid state biomass production.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141096431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The potential use of natural killer cells to treat Alzheimer's disease: Can nutrition play a role?","authors":"Athena Dong, Yi-Wen Huang, Huizhi Chen, Ruiling Liu, Weijie Wu, Haiyan Gao, Chin-Kun Wang, Jianhua Yu, Li-Shu Wang","doi":"10.1002/efd2.145","DOIUrl":"https://doi.org/10.1002/efd2.145","url":null,"abstract":"<p>According to the World Health Organization (WHO), dementia is a significant cause of disability and dependency among older individuals globally (Wortmann, <span>2012</span>). Among the various types of dementia, Alzheimer's disease (AD) is the most prevalent, accounting for over 60% of cases (<span>2020</span>). It is important to note that AD cases can be categorized into two main types: early-onset familial AD, which accounts for less than 1% of cases, and late-onset sporadic AD, which comprises approximately 95% of cases (Drummond & Wisniewski, <span>2017</span>).</p><p>The hallmark characteristics of AD are the presence of extracellular amyloid β (Aβ) plaques and intraneuronal phosphorylated tau (p-Tau) aggregates, known as neurofibrillary tangles (Yeh et al., <span>2017</span>). Neurons in the brain produce significant amounts of Aβ (Busciglio et al., <span>1993</span>). Microglia, which are the macrophages of the brain and play a substantial role in neuroinflammation, bind to the Aβ peptide to help clear it from the brain (Yeh et al., <span>2017</span>). APOE4 and TREM2*R47H are two crucial genetic risk factors in the late-onset sporadic AD population (Le Guen et al., <span>2022</span>; Guerreiro et al., <span>2013</span>; Jonsson et al., <span>2013</span>). These genetic variants contribute to impaired uptake of Aβ and the subsequent accumulation of Aβ (Yeh et al., <span>2017</span>), a critical molecule involved in the initiation of neuronal degeneration (Leng & Edison, <span>2021</span>). The accumulation of Aβ activates the phagocytic function of microglia to degrade Aβ and triggers pro-inflammatory pathways (Leng & Edison, <span>2021</span>). Moreover, activated microglia release reactive oxygen species and pro-inflammatory cytokines, leading to neuronal dysfunction and progressive cell death as the disease advances (Alawieyah Syed Mortadza et al., <span>2018</span>; Combs et al., <span>2001</span>).</p><p>Multiple phase 3 human clinical trials targeting Aβ in early-stage AD patients (mild cognitive impairment or mild dementia due to AD) have been conducted around the world; however, showing discouraging results with respect to Bapineuzumab (a humanized anti-amyloid-beta monoclonal antibody) (Salloway et al., <span>2014</span>), Lecanemab (a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ soluble protofibrils) (van Dyck et al., <span>2023</span>), Aducanumab (a human monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta) (Budd Haeberlein et al., <span>2022</span>), Crenezumab (a humanized monoclonal immunoglobulin G4 antibody targeting β-amyloid oligomers) (Ostrowitzki et al., <span>2022</span>), Gantenerumab (a fully human monoclonal antibody that binds aggregated Aβ and removes Aβ plaques by Fc receptor-mediated phagocytosis) (Ostrowitzki et al., <span>2017</span>), and Solanezumab (a humanized monoclonal antibody, preferentially binds soluble forms of amyloi","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141096434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent research progress in the plant contribution to the management of tuberculosis","authors":"Elwira Sieniawska","doi":"10.1002/efd2.157","DOIUrl":"https://doi.org/10.1002/efd2.157","url":null,"abstract":"<p>Tuberculosis is an infectious disease caused by <i>Mycobacterium tuberculosis</i>. Despite the successes in the development of diagnosis and treatment of this disease, it still poses a significant threat to humanity, especially in countries with an average and low level of healthcare development (Maiolini, <span>2020</span>). The newest World Health Organization, Global Tuberculosis Report (<span>2023</span>) revealed that the reported global number of people newly diagnosed with TB was 7.5 million in 2022. This is the highest number since WHO began global TB monitoring in 1995, above the pre-COVID baseline. Globally in 2022, <i>M. tuberculosis</i> caused an estimated 1.30 million deaths. Also, the number of people with multidrug-resistant(MDR) or rifampicin-resistant tuberculosis increased with 450,000 new cases (World Health Organization, Global Tuberculosis Report, <span>2023</span>). Moreover, the last decade has seen an increase in the number of cases of extremely drug-resistant tuberculosis (XDR-TB), defined as MDR-TB with additional resistance to at least one of the fluoroquinolones and one of the drugs administered in the form of injections (amikacin, kanamycin, capreomycin) used in MDR-TB treatment regimens. In the era of global population movements, the emergence of MDR-TB and XDR-TB makes the fight against tuberculosis an ongoing challenge (World Health Organization, Global Tuberculosis Report, <span>2019</span>). Current treatment recommendations require the use of combinations of different drugs for periods ranging from 6 months to 9–20 months (MDR-TB). However, in the case of XDR tuberculosis, or when the treatment results are not satisfactory, the duration of treatment may be much longer (World Health Organization, Global Tuberculosis Report, <span>2019</span>). Failure in antituberculosis therapy is caused mainly by its long duration, complicated drug regimens, strong side effects of antituberculosis drugs, and their interactions with drugs used in other disease units (Shehzad, <span>2013</span>). What is more, in 2021, for the first time in 9 years, the estimated number of deaths from tuberculosis increased, which was caused by limited access to health care due to the COVID-19 pandemic. As a result, an estimated half of the infections went undiagnosed and untreated. The report also indicates that there has been a reduction in funding for tuberculosis treatment and BCG vaccines in children. The COVID-19 pandemic outbreak in 2020 disrupted essential health services and placed an additional burden on people with tuberculosis (World Health Organization, Global Tuberculosis Report, <span>2021</span>). Nevertheless, the fight against tuberculosis is still ongoing and plant products play an important role in it.</p><p>Plants are essential for human living. Besides providing food for people and feed for animals, plants create a natural environment, produce oxygen, and supply various raw materials. Since ancient times people used plant","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myricetin and dihydromyricetin as JNK1 inhibitors protect against ROS-mediated oxidative stress and apoptosis","authors":"Rili Hao, Xinyu Song, Yajie Li, Xinru Lin, Hui Guan, Dongxiao Sun-Waterhouse, Dapeng Li","doi":"10.1002/efd2.155","DOIUrl":"https://doi.org/10.1002/efd2.155","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Reactive oxygen species (ROS)-mediated oxidative stress and apoptosis contribute to the pathogenesis and pathological conditions of various diseases induced by food and environmental pollutants. Myricetin and dihydromyricetin, as natural flavonoids, can counteract oxidative damage, apoptosis, and associated diseases. Molecular docking analysis, ELISA, fluorescence spectroscopy, and Western blot techniques were applied to examine the potential of the two flavonoids as effective therapeutics for ROS-mediated diseases and the mechanism(s) underlying their protective effects against ethanol/H<sub>2</sub>O<sub>2</sub>-induced damage. In Kunming mice and HepG2 cells, myricetin and dihydromyricetin inhibited ethanol/H<sub>2</sub>O<sub>2</sub>-induced liver damage, ROS accumulation, and oxidative stress and apoptosis. Molecular docking showed that myricetin and dihydromyricetin interacted with JNK1 via hydrophobic interactions and hydrogen bonds, thereby exerting their protective effects. The significant differences in their binding patterns to JNK1 resulted from the different bond types between C2 and C3 on their C ring. Myricetin and dihydromyricetin likely protected liver injury via counteracting ROS/JNK1-mediated oxidative stress and apoptosis. The finding that the suppression of ROS-mediated oxidative stress and apoptosis by flavonoids via interacting with functional proteins, such as kinase, may represent an alternative strategy for treating excessive ROS-induced health problems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Gao, Chao Xu, Guifang Tian, Yue Hong Ji, Faizan A. Sadiq, Ke Wang, Yaxin Sang
{"title":"A study revealing mechanisms behind the stone cell of Yali pear degradation by mixed-culture fermentation of lactic acid bacteria and yeast","authors":"Jie Gao, Chao Xu, Guifang Tian, Yue Hong Ji, Faizan A. Sadiq, Ke Wang, Yaxin Sang","doi":"10.1002/efd2.153","DOIUrl":"https://doi.org/10.1002/efd2.153","url":null,"abstract":"<p>The presence of stone cells in pears is recognized as a problem for the pear processing industry. <i>Bacillus</i> and mold can degrade stone cells because of their potential to digest cellulose and lignin, but they cannot be used for the degradation test of pear stone cells. In this study <i>Lactoplantibacillus plantarum</i> JYLP-326 was used in single culture or in the mixed culture with <i>Saccharomyces cerevisiae</i> Y2 to study their potential to degrade stone cells during fermentation and the mechanism of degradation was further explored. Synergy in cellulase activity was observed in the mixed-culture where the maximum activity was observed at 96th hour of fermentation. Activities of endoglucanase, exoglucanase and β-glucosidase were 1.75, 4.58, and 2.31. The degradation rate of stone cells in the mixed-culture was 37.67%, which was significantly higher than that the results obtained for single cultures. The results of scanning electron microscopy (SEM) showed that the surface of the cultured stone cells became rough. Metabolomics studies confirmed the presence of specific metabolites related to the degradation of stone cells after the fermentation. It was concluded that the mixed-culture fermentation using the above-mentioned strains could be exploited by the pear processing industry to degrade stone cells.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inulin alleviates acute alcoholism in mice by enhancing ethanol metabolism and regulating the intestinal flora","authors":"Zhouya Bai, Honglin Lan, Denglin Luo, Xingguo Li, Yunhui Zhang, Mengyuan Geng, Shaohe Chang","doi":"10.1002/efd2.152","DOIUrl":"https://doi.org/10.1002/efd2.152","url":null,"abstract":"<p>Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study investigated the antialcoholic effects of short, long, and phosphorylated long-chain inulin and the possible mechanisms. An acute alcoholic intoxication mice model was established, with the water extract of <i>Hovenia dulcis Thunb</i> serving as a positive control. The different inulins were used for intervention, and the drunkenness of the mice was observed by an animal behavior experiment. The serum liver function indexes (TP, ALB, GLB, ALT, and ALP), as well as the activity of ethanol metabolizing enzymes (ADH and ALDH) in the liver were measured, and the changes in intestinal flora were analyzed. The results showed that short-chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of extraction methods on functional properties of plant proteins: A review","authors":"Akshay S. Chandran, Piyush Kashyap, Mamta Thakur","doi":"10.1002/efd2.151","DOIUrl":"https://doi.org/10.1002/efd2.151","url":null,"abstract":"<p>Food proteins should not only provide nutrition but should also have specific functional properties that facilitate processing and enhance product performance. These functional properties refer to the physicochemical characteristics that govern the behavior of proteins in food. In this context, this article delves into the impact of extraction techniques on functional properties of protein, like solubility, emulsifying, foaming, and oil and water holding capacity. Novel extraction methods can boost extraction yield and enhance technological, functional, and nutritional properties of protein. Protein solubility was found to be significantly impacted by the application of novel extraction methods. Studies also concluded that enhancing the solubility of commercial protein isolates may lead to better functional properties. However, excessive use of extraction techniques can result in protein aggregation, which can negatively impact the foaming properties. Exposing hydrophobic groups and enhancing flexibility are the effects of novel treatment on different proteins resulting in an improvement in their functional properties. Similarly alkaline and micellized extraction also enhance the proteins properties. These findings will result in a further enrichment of the research on the functional properties of protein and provide information to help in the development of protein enriched food products.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicky R. Putra, Dwila N. Rizkiyah, Mohd A. Che Yunus, Lailatul Qomariyah
{"title":"Towards a greener future: Bioactive compounds extraction from shrimp shells using eco-friendly techniques","authors":"Nicky R. Putra, Dwila N. Rizkiyah, Mohd A. Che Yunus, Lailatul Qomariyah","doi":"10.1002/efd2.146","DOIUrl":"https://doi.org/10.1002/efd2.146","url":null,"abstract":"<p>This review explores the impact of green extraction techniques on the utilization of shrimp shell waste, focusing on the extraction of bioactive compounds. The purpose of this research is to assess the effectiveness of eco-friendly extraction methods in maximizing the value of shrimp shell waste while minimizing environmental impact. Through a comprehensive analysis of recent studies, the findings reveal the significant potential of green extraction techniques, such as ultrasound-assisted extraction and enzyme-assisted extraction, in efficiently extracting bioactive compounds from shrimp shells. These techniques not only enhance the extraction yield but also contribute to reducing energy consumption and minimizing the use of hazardous chemicals. The review also discusses the challenges and future directions in green extraction, highlighting the need for interdisciplinary collaboration and technological innovation to further optimize extraction processes. Overall, the adoption of green extraction techniques offers promising opportunities for sustainable shrimp shell waste utilization, with potential applications in various industries such as pharmaceuticals, nutraceuticals, and cosmetics.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140546655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discovery of vitexin as a novel α-glucosidase inhibitors in mulberry (Morus alba L.) by untargeted metabolomics combined with molecular docking: A comprehensive study from mechanism to synergy effects","authors":"Zichun Wang, Lu Zhang, Meng Wang, Zhenjiang Ding, Difeng Ren, Shenglin Duan","doi":"10.1002/efd2.144","DOIUrl":"https://doi.org/10.1002/efd2.144","url":null,"abstract":"<p>Mulberry (<i>Morus alba</i> L.) leaf can effectively inhibit the digestion of starchy foods, and α-glucosidase (AG) is its main target. This study employed an untargeted metabolomics approach combined with molecular docking to identify AG inhibitors. Subsequently, inhibition kinetics, fluorescence spectroscopy, and interaction force analysis were utilized to investigate the inhibitory mechanism. Results indicated that vitexin exhibited significant reversible inhibition of AG through competitive inhibition, with an IC<sub>50</sub> value of 105.50 ± 1.30 μg/mL. Molecular docking revealed hydrogen bonding as the main interaction force between vitexin and AG, and quenching mechanism analysis showed that they underwent static quenching driven by entropy. The results of the combined experiment showed that 1-deoxynojirimycin (DNJ), a known bioactive component in mulberry, has a synergistic effect of inhibiting AG activity with vitexin. This study elucidates the potential mechanism of vitexin in inhibiting AG activity and provides theoretical evidence for utilizing vitexin-DNJ complexes as functional components of AG inhibitors.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140546753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of abscisic acid treatment on postharvest storage quality and volatile flavor substances in blueberries","authors":"Huiru Qiao, Weijie Wu, Yiqin Zhang, Qi Kong, Hangjun Chen, Lishu Wang, Xiangjun Fang, Haiyan Gao","doi":"10.1002/efd2.148","DOIUrl":"https://doi.org/10.1002/efd2.148","url":null,"abstract":"<p>To investigate the impact of abscisic acid (ABA) on the postharvest flavor and quality of blueberries, this study employed different concentrations of ABA (400 μM ABA, 600 μM ABA, and 800 μM ABA) to treat the blueberries. The treated blueberries were then stored at 4°C (~80% relative humidity) for 35 day. Subsequently, genes associated with the metabolism of volatile aromatic substances and fatty acids in postharvest blueberries were assessed using real-time PCR. Our results revealed that the treatment of ABA could maintain a high level of nutrient and aromatic substances in blueberries. Particularly, 600 μM ABA caused most significant changes in fatty acid metabolism-related enzyme activities, such as lipoxygenase, hydroperoxide lyase, alcohol dehydrogenase, as well as related gene expressions, like <i>VcLOX2S</i>, <i>VcHPL</i>, <i>VcADH1-1</i>, <i>VcADH1-2</i>, <i>VcADH1-3</i>, and <i>VcADH1-4</i>. In addition, Furthermore, the blueberries treated with 600 μM ABA exhibited a superior quality when compared to the control group. This superior quality included higher levels of total acid, ascorbic acid, total phenol, anthocyanin, soluble sugar contents, and so forth. In conclusion, postharvest ABA treatment decelerated the decrease in volatile aroma substances and effectively maintained the flavor of blueberries.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140546754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}