eFood最新文献 - Book学术

The stability and bioavailability of xanthohumol loaded by sophorolipid-based microemulsions in functional beer 苦参脂微乳负载黄腐酚在功能性啤酒中的稳定性和生物利用度

IF 4

eFood Pub Date : 2024-12-18 DOI: 10.1002/efd2.161

Qiannan Pan, Cheng Chen, Jingyang Luo, Weisu Huang, Yuhang Zhu, Kejie Peng, Zefeng Guo, Baiyi Lu

{"title":"The stability and bioavailability of xanthohumol loaded by sophorolipid-based microemulsions in functional beer","authors":"Qiannan Pan, Cheng Chen, Jingyang Luo, Weisu Huang, Yuhang Zhu, Kejie Peng, Zefeng Guo, Baiyi Lu","doi":"10.1002/efd2.161","DOIUrl":"https://doi.org/10.1002/efd2.161","url":null,"abstract":"Xanthohumol (XN) exhibits numerous physiological activities, yet its instability and proneness to degradation limit its use. Microemulsions, noted for effective drug solubilization and delivery, have been employed to enhance XN's stability and bioavailability in functional beers, using sophorolipids (SL) and Tween 80 (T80) as surfactants. Our development of T80-ME and T80-SL-ME stabilized XN, as confirmed by reduced degradation in high-performance liquid chromatography analysis and kinetic modeling. We established in vitro release and in vivo pharmacokinetic models, demonstrating improved outcomes with XN-enriched beer. Our study also assessed total phenols, flavonoids, and antiaging effects in the beer. The formulation minimally affected beer's physicochemical properties, including pH, turbidity, and bitterness. Notably, XN's bioavailability in beer improved 1.79- to 7.33-fold, underscoring microemulsion technology's role in enhancing XN absorption and metabolism. We analyzed the sensory flavor impact of SL biosurfactants in beer, finding them acceptable to consumers. This study highlights microemulsions' potential in elevating functional beer's nutritive value and applications.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel HP2MGL resin-based enrichment of flavonoids from Dendrobium catenatum flower and their antiaging efficacy 新型HP2MGL树脂富集石斛花黄酮类化合物及其抗衰老作用

IF 4

eFood Pub Date : 2024-12-17 DOI: 10.1002/efd2.70018

Yuntao Guo, Danni Lai, Fupeng Pan, Maidinai Sabier, Jingjing Liu, Qiaoxian Yu, Pan Wang, Jinping Si, Xinfeng Zhang

{"title":"Novel HP2MGL resin-based enrichment of flavonoids from Dendrobium catenatum flower and their antiaging efficacy","authors":"Yuntao Guo, Danni Lai, Fupeng Pan, Maidinai Sabier, Jingjing Liu, Qiaoxian Yu, Pan Wang, Jinping Si, Xinfeng Zhang","doi":"10.1002/efd2.70018","DOIUrl":"https://doi.org/10.1002/efd2.70018","url":null,"abstract":"This study aimed to enrich flavonoids from Dendrobium catenatum Wall ex Lindl flowers using macroporous resins and investigate their bioactivity. The optimal enrichment process with HP2MGL resin was established with a total flavonoid concentration of 0.50 mg/mL, a sample flow rate of 1 BV/h, and a sample volume of 25.5 BV. Desorption was performed using 80% ethanol at a flow rate of 3 BV/h and an eluent volume of 5 BV. The purified extract showed a 7.3-fold increase in purity compared to the crude extract. A total of 33 major compounds in the purified flavonoids were identified and quantified, including flavonols and flavonoid C-glycosides, with hyperoside being the most abundant. In vivo tests demonstrated that the enriched extract extended the lifespan of Caenorhabditis elegans, enhanced locomotion, and increased superoxide dismutase activity while significantly reducing oxidative stress markers such as lipofuscin, reactive oxygen species, and malondialdehyde. The findings provide a practical method for large-scale extraction of flavonoids from D. catenatum flowers and suggest that Dendrobium catenatum flower extract (DCFE-E) exhibits strong antiaging properties, indicating potential applications in functional foods and cosmetics. This research contributes to the scientific understanding of D. catenatum resource utilization and enhances the value of its products.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging HPLC-ESI-MS/MS analysis and in vitro biological activity assay through molecular docking and network pharmacology: The example of European nettle tree (Celtis australis L.) 通过分子对接和网络药理学连接 HPLC-ESI-MS/MS 分析和体外生物活性测定：以欧洲荨麻树（Celtis australis L.）为例

IF 4

eFood Pub Date : 2024-12-09 DOI: 10.1002/efd2.70026

Mehmet Veysi Cetiz, Sakina Yagi, Umran Kurt, Ismail Koyuncu, Ozgur Yuksekdag, Giovanni Caprioli, Laura Acquaticci, Simone Angeloni, Ismail Senkardes, Gokhan Zengin

{"title":"Bridging HPLC-ESI-MS/MS analysis and in vitro biological activity assay through molecular docking and network pharmacology: The example of European nettle tree (Celtis australis L.)","authors":"Mehmet Veysi Cetiz, Sakina Yagi, Umran Kurt, Ismail Koyuncu, Ozgur Yuksekdag, Giovanni Caprioli, Laura Acquaticci, Simone Angeloni, Ismail Senkardes, Gokhan Zengin","doi":"10.1002/efd2.70026","DOIUrl":"https://doi.org/10.1002/efd2.70026","url":null,"abstract":"Celtis australis L. (Family: Cannabaceae) is commonly used to treat many diseases like gastrointestinal problems, menstrual bleeding and amenorrhea. The present study was designed to investigate the chemical constituents, antioxidant, enzyme inhibitory and cytotoxic properties of different extracts from twigs, fruits and leaves of C. australis. EtOAc, EtOH, 70% EtOH and aqueous extracts were prepared by maceration. Results showed that the EtOH extract of the leaves had the highest total phenolic content and possessed remarkable antiradical, ion reducing and total antioxidant activities. Additionally, the leaves (EtOH or EtOAc extracts) exerted the best enzyme inhibition properties. The polar extracts of the leaves had significant cytotoxic effect against the human colorectal adenocarcinoma (HT-29) and human prostate cancer (DU-145) cell lines while the EtOAc of the twigs was effective against the former cell line. Phytochemically, the twigs and fruits accumulated high content of vanillic acid, 4-hydroxy benzoic acid and syringic acid. Through a combination of in vitro and in silico approaches, we identified key phytochemicals exhibited significant inhibitory effects on several cancer-related proteins, through in vitro and in silico approaches that show significant inhibition of cancer-related proteins. In conclusion, these findings indicated that C. australis could be a promising source of bioactive molecules for food, pharmaceutical and cosmetic industries.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress of Arbutin from Dietary Supplement to Advanced Medicine 熊果苷从膳食补充剂到先进药物的发展历程

IF 4

eFood Pub Date : 2024-12-09 DOI: 10.1002/efd2.70013

Pooja Mishra, Farogh Ahsan, Tarique Mahmood, Shahzadi Bano, Arshiya Shamim, Vaseem Ahamad Ansari, Jyoti Yadav

{"title":"Progress of Arbutin from Dietary Supplement to Advanced Medicine","authors":"Pooja Mishra, Farogh Ahsan, Tarique Mahmood, Shahzadi Bano, Arshiya Shamim, Vaseem Ahamad Ansari, Jyoti Yadav","doi":"10.1002/efd2.70013","DOIUrl":"https://doi.org/10.1002/efd2.70013","url":null,"abstract":"Arbutin, a naturally occurring hydroquinone, has gained attention for its diverse pharmacological properties. Traditional uses include blood sugar regulation and wound healing, while modern applications focus on its antioxidant and anti-inflammatory effects. Its synthesis involves complex biochemical pathways, contributing to its unique characteristics. Pharmacokinetic studies have shed light on its absorption, distribution, metabolism, and excretion, crucial for understanding its efficacy. Toxicity concerns underscore the need for further research into its safety. Additionally, novel dosage forms of arbutin are explored, presenting innovative strategies to enhance its delivery and efficacy in therapeutic applications. Arbutin's pharmacological activities span antioxidant, anti-inflammatory, and glucose metabolism regulation thus modulating various molecular pathways and targets, such as glucose transporter-4, insulin-like growth factor-1 receptor, and adenosine monophosphate-activated protein kinase, offering promising therapeutic avenues in medicine. This review covers arbutin comprehensively, encompassing its sources, chemical properties, synthesis methods, pharmacokinetics, pharmacological activities, food supplements, toxicity profiles, and novel dosage forms. By addressing these aspects, the review lays the groundwork for future research and development in natural therapeutics.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Volatile Organic Compounds of Different Types of Peppers (Capsicum annuum L.) Using Comprehensive Two-Dimensional Gas Chromatography With Time-of-Flight Mass Spectrometry

IF 4

eFood Pub Date : 2024-12-03 DOI: 10.1002/efd2.70027

Huixia Zhu, Min Wei, Yuxin Zhang, Xinglin Tao

{"title":"Analysis of Volatile Organic Compounds of Different Types of Peppers (Capsicum annuum L.) Using Comprehensive Two-Dimensional Gas Chromatography With Time-of-Flight Mass Spectrometry","authors":"Huixia Zhu, Min Wei, Yuxin Zhang, Xinglin Tao","doi":"10.1002/efd2.70027","DOIUrl":"https://doi.org/10.1002/efd2.70027","url":null,"abstract":"As a vegetable and spice crop, the quality of pepper (Capsicum annuum L.) is considerably affected by flavor. However, research on flavor of different C. annuum L. varieties, such as the fruits of “Gansu Xianjiao” (GX) and “Gansu Banjiao” (GB), is limited. In this study, comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry and multivariate statistical analysis were used to elucidate the flavor differences between GX and GB. A total of 2458 volatile organic compounds (VOCs) were identified, with GX and GB possessing 1914 and 1802 VOCs, respectively. Multivariate statistical analysis revealed 215 differential VOCs in GX versus GB. The relative contents of pyrazine, 2-ethenyl-6-methyl and 1-cyclohexene-1-carboxylic acid, 2,6,6-trimethyl-, ethyl ester were most significantly increased, whereas those of 4-methylpentyl 4-methylpentanoate methional and 2-furanmethanol,5-methyl- were most significantly decreased. Further, these differential VOCs were correlated with sensory attributes, such as the sweetness, fruitiness, and green aroma. This study will provide deeper insights into improving the flavor quality of C. annuum L.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional beverage based on aguamiel pasteurized by ultrasound and microwaves with antihypertensive properties 用超声波和微波巴氏杀菌的具有降血压功效的阿瓜米尔功能饮料

IF 4

eFood Pub Date : 2024-11-25 DOI: 10.1002/efd2.70019

Lucia Perales-Serna, Dora Elisa Cruz-Casas, Adriana C. Flores-Gallegos, Anilú Rubio-Ríos, Juan Alberto Ascacio-Valdes, Aidé Sáenz-Galindo, Raúl Rodríguez-Herrera

{"title":"Functional beverage based on aguamiel pasteurized by ultrasound and microwaves with antihypertensive properties","authors":"Lucia Perales-Serna, Dora Elisa Cruz-Casas, Adriana C. Flores-Gallegos, Anilú Rubio-Ríos, Juan Alberto Ascacio-Valdes, Aidé Sáenz-Galindo, Raúl Rodríguez-Herrera","doi":"10.1002/efd2.70019","DOIUrl":"https://doi.org/10.1002/efd2.70019","url":null,"abstract":"Currently, microwaves, ultrasound, and ultrasound-microwaves are technologies with several applications, one of which is their use as a method of pasteurization. So far, these techniques have not been used for the pasteurization of a functional aguamiel beverage. This beverage was pasteurized and enriched with probiotic LAB to generate an antihypertensive effect. The physicochemical characteristics (pH, total soluble solids, and color) of the aguamiel beverage were evaluated. Microbiological analysis of the product was also carried out. The probiotic LAB were added to the beverage with the selected pasteurization technique. The growth of LAB in the aguamiel beverage and the prebiotic effects that this product as well as the antihypertensive activity of the beverage were evaluated. It was shown that there is no significant effect of the techniques used on the physicochemical characteristics of the product. However, the storage time may be affected. Compared to traditional pasteurization, microwave, ultrasound, and ultrasound-microwave techniques were found to reduce the concentration of some pathogenic microorganisms. The microwave technique was selected as the most effective for pasteurization. The probiotic LAB were able to grow in the pasteurized aguamiel beverage and produce an antihypertensive effect. In summary, a functional microwavable pasteurized aguamiel beverage with antihypertensive activity was produced.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research hotspots and evolution trends of food safety risk assessment techniques and methods 食品安全风险评估技术和方法的研究热点和演变趋势

IF 4

eFood Pub Date : 2024-11-12 DOI: 10.1002/efd2.70025

Liru Wang, Xueli Yu

{"title":"Research hotspots and evolution trends of food safety risk assessment techniques and methods","authors":"Liru Wang, Xueli Yu","doi":"10.1002/efd2.70025","DOIUrl":"https://doi.org/10.1002/efd2.70025","url":null,"abstract":"Food safety incidents frequently occur in China and other countries. Food safety risk management has evolved from harm-based to risk-based approaches to control risks more scientifically and effectively. Risk assessment is at the core of risk control and provides a scientific basis for the development of risk management measures. Therefore, analyzing the research status and development trends of food safety risk assessment technologies and methods is important for improving food safety risk assessment and risk management. In this study, CiteSpace software was used to analyze a knowledge graph of popular research topics in the field of food safety risk assessment over the past 14 years, identify research keywords, and provide centrality statistics. Food safety risk assessments primarily focus on in vitro high-throughput testing, computational toxicology, predictive microbiology, mechanistic research, and other technical methods. In the future, international coordination, cooperation, and cross-integration of relevant disciplines should be strengthened, and research on and application of innovative technologies for food safety risk assessment should be promoted. Research on food safety risk assessment technologies and methods is in an active development stage and has good prospects for further exploration and application.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights into acetyl triethyl citrate (ATEC) induced toxic effect in HepG2 cells based on multi-omics integrative analysis 基于多组学整合分析的柠檬酸乙酰三乙酯（ATEC）诱导 HepG2 细胞毒性效应的分子见解

IF 4

eFood Pub Date : 2024-11-11 DOI: 10.1002/efd2.70024

Bing Jie Ma, Lu Chen, Rui Weng, Jia Xi Liu, Xiao Qian Yin, Yu Shun Lu, Jing Qiu, Yong Zhong Qian, Yan Yang Xu

{"title":"Molecular insights into acetyl triethyl citrate (ATEC) induced toxic effect in HepG2 cells based on multi-omics integrative analysis","authors":"Bing Jie Ma, Lu Chen, Rui Weng, Jia Xi Liu, Xiao Qian Yin, Yu Shun Lu, Jing Qiu, Yong Zhong Qian, Yan Yang Xu","doi":"10.1002/efd2.70024","DOIUrl":"https://doi.org/10.1002/efd2.70024","url":null,"abstract":"Citrate esters have become the main alternatives to traditional plasticizers in food packaging materials. However, there is a lack of understanding of their toxic effects, particularly the combined effects and inner mechanisms has not been well studied. Our group pioneered the study on combined toxicity of tributyl citrate (TBC) and acetyl triethyl citrate (ATEC), two commonly co-used citrate esters in food packaging materials. The results showed that exposure to TBC and ATEC can decrease the viability of HepG2 cells in a dose dependent manner. When the mixtures of ATEC and TBC exposed to HepG2 cells, they exhibited antagonism effect. Therefore, ATEC was selected to investigate the molecular mechanisms with multi-omics techniques at its 1/4 EC50 concentration. A total of 31 metabolites with significant changes were found as potential biomarkers. The LIPG (Lipase G, endothelial type) and GCLM (glutamate-cysteine ligase modifier subunit) were identified as differentially expressed genes based on transcriptomic analysis. Moreover, downregulated l-glutamate and l-glutamine which participate in TCA cycle, resulting in the collapse of energy production and cytotoxicity. These findings on major metabolic pathways will provide insight into the mechanism of cytotoxicity of HepG2 cells after ATEC exposure.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and quality evaluation of mixed fruit jam made from natural and artificial sweetener 天然和人工甜味剂混合果酱的制备和质量评价

IF 4

eFood Pub Date : 2024-11-08 DOI: 10.1002/efd2.70022

Muhammad Haroon, Imran Khan, Afaf Ejaz, Muhammad Afzaal, Farhan Saeed, Muhammad Umar Farooq, Maryam Ehsan, Faiyaz Ahmed, Noor Akram, Gebremichael Gebremedhin Hailu

{"title":"Preparation and quality evaluation of mixed fruit jam made from natural and artificial sweetener","authors":"Muhammad Haroon, Imran Khan, Afaf Ejaz, Muhammad Afzaal, Farhan Saeed, Muhammad Umar Farooq, Maryam Ehsan, Faiyaz Ahmed, Noor Akram, Gebremichael Gebremedhin Hailu","doi":"10.1002/efd2.70022","DOIUrl":"https://doi.org/10.1002/efd2.70022","url":null,"abstract":"In this study nutritionally enriched apple and date jam was developed by replacing sugar with natural and artificial sweeteners stevia and sorbitol. Three different types of samples were prepared. Sample T1 was prepared by using stevia as a sweetener agent. Sample T2 was prepared by using sorbitol as a sweetener agent. Sample T3 was prepared by using a mixture of stevia and sorbitol as sweetener agents. Standard apple jam was used as a control sample labeled as T4 and was used for comparison analysis. The developed product was analyzed by physiochemical analysis and sensory evaluation. Microbial analysis was done to study the shelf life study of the developed product. The study showed that stevia and sorbitol could be used for jam preparation. Sample T3 also showed intermediate values of acidity and pH as 4.14 and 1.90, respectively, moreover, total soluble solids (TSS) was observed as 65.16 °Brix, T3 also showed an intermediate level of energy values. Sample T3 having sorbitol and stevia sweetener agents had the highest rate of overall acceptability. Storage studies of all samples show that with the passage of time all sensory characteristics of all treatments decreased.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Mesembryanthemum crystallinum and its derived D-pinitol on HMG-CoA reductase and tyloxapol-induced hyperlipedemia 结晶中菊花及其衍生物 D-匹尼醇对 HMG-CoA 还原酶和泰乐菌素诱导的高脂血症的影响

IF 4

eFood Pub Date : 2024-11-08 DOI: 10.1002/efd2.70020

Jun-Hui Choi, Se-Eun Park, Seung Kim

{"title":"Effect of Mesembryanthemum crystallinum and its derived D-pinitol on HMG-CoA reductase and tyloxapol-induced hyperlipedemia","authors":"Jun-Hui Choi, Se-Eun Park, Seung Kim","doi":"10.1002/efd2.70020","DOIUrl":"https://doi.org/10.1002/efd2.70020","url":null,"abstract":"Several previous research indicate that treating Mesembryanthemum crystallinum may aid in reducing adipogenesis and triacylglycerol level and improving hyperglycemia and diabetes. Therefore, the present study was designed to evaluate the effectiveness of M. crystallinum extract (MCE) in combating obesity and lowering fat/lipid/cholesterol levels. The study aimed to investigate the molecular docking model targeting 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) using MCE-derived d-pinitol or atorvastatin, an inhibitor of HMGCR. In this study, histological alterations in the liver of tyloxapol-induced hyperlipidemia (TIH) model, hyperlipidemia-related markers in serum, HMGCR activity, and cell viability in HepG2 cells were analyzed. Our findings revealed that tyloxapol treatment significantly led to increased hyperlipidemia-related indicators and cardiovascular-associated risk indices. However, MCE effectively mitigated tyloxapol-induced hepatic fat accumulation and an increase in cholesterol levels. This was achieved through improvements in metabolic parameters, ultimately ameliorating TIH. These beneficial results suggest that MCE may be a strong potential for the treatment of hyperlipidemia-related diseases.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 6","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0