eFood最新文献

{"title":"Pilot Study of a Herbal Formulation Composed of Bidens pilosa for Constipation in Humans","authors":"Tien-Fen Kuo,&nbsp;Yi-San Lee,&nbsp;Greta Yang,&nbsp;Yu-Chuan Liang,&nbsp;Wen-Chin Yang","doi":"10.1002/efd2.70205","DOIUrl":"https://doi.org/10.1002/efd2.70205","url":null,"abstract":"<p>The gut microbiota and their metabolites are associated with constipation and other gastrointestinal diseases. Dietary phytochemicals are crucial factors shaping gut microbiota. Here, we conducted a first-in-human trial of the herbal formulation BP, composed of a <i>Bidens pilosa</i> extract and excipient, in volunteers with constipation. Data from the Bristol Stool Form Scale, Cleveland Clinic Constipation Score, and the Quality of Life Scale for Patients with Constipation indicated that BP improved constipation and quality of life in patients with constipation. Metagenomic data showed that BP increased the abundance of bacterial genera with beneficial potential and decreased the abundance of those with harmful potential in the stools of most volunteers. To dissect the clinical mechanism of BP, loperamide-treated mice were used to tease out its anti-constipation mechanism. Mouse data demonstrated that BP improved loperamide-induced constipation and modulated the gut microbiota. Mechanistically, BP at ≥ 0.5 μg/mL promoted probiotics, including <i>Bifidobacterium</i> and <i>Lactobacillus</i>, and at 800 μg/ml or higher, it inhibited pathogens, such as <i>Escherichia coli</i>, <i>Salmonella enterica</i>, and <i>Clostridium difficile</i>. Inter-bacterial antagonism data revealed that probiotics inhibited pathogens. Collectively, BP promoted relief of constipation and modulated the gut microbiota, involving increased levels of probiotics and their metabolites that antagonized pathogenic bacteria.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Preservation of Refrigerated Chicken Meat Using Asphodelus microcarpus Root Extract With Machine-Learning-Based Shelf-Life Prediction","authors":"Enaam Elsomadi,&nbsp;Boutheina Ben Akacha,&nbsp;Wirginia Kukula-Koch,&nbsp;Narjes Baazaoui,&nbsp;Monika Michalak,&nbsp;Miroslava Kačániová,&nbsp;Wojciech Koch,&nbsp;Sirine Choura,&nbsp;Mohamed Chamkha,&nbsp;Rania Ben Saad,&nbsp;Stefania Garzoli,&nbsp;Anis Ben Hsouna","doi":"10.1002/efd2.70208","DOIUrl":"https://doi.org/10.1002/efd2.70208","url":null,"abstract":"&lt;p&gt;The demand for natural and multifunctional food preservatives has increased due to growing concerns about the safety and sustainability of synthetic additives. In this study, the ethyl acetate extract of &lt;i&gt;Asphodelus microcarpus&lt;/i&gt; roots (&lt;i&gt;Am&lt;/i&gt;EA) was evaluated as a preservative, integrating antioxidant and antibacterial evaluation with an artificial intelligence (AI)-assisted shelf-life prediction approach. The extraction yield of &lt;i&gt;Am&lt;/i&gt;EA was 1.15% ± 0.06% (obtained from 100 g of dried root powder using a 1:5 w/v ratio of ethyl acetate over a 24 h triple maceration period), with a high total polyphenol content (444.6 ± 0.4 mg GAE/g extract) and a comparatively low total flavonoid content, indicating enrichment in non-flavonoid phenolic compounds. HPLC-DAD and GC–MS analyses revealed a complex phytochemical profile dominated by phenolic acids (vanillic and ferulic acids), flavonoids (apigenin-7-glucoside and naringenin), and anthraquinone derivatives (aloe-emodin and chrysophanol). The extract exhibited a radical-scavenging capacity in the DPPH assay (IC&lt;sub&gt;50&lt;/sub&gt; = 5.24 µg/mL), indicating effective hydrogen-donating ability under in vitro conditions. &lt;i&gt;Am&lt;/i&gt;EA demonstrated broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, with inhibition zones up to 26 ± 0.44 mm and minimum inhibitory concentrations (MICs) as low as 0.3 mg/mL. Bactericidal activity (MBC/MIC ≤ 4) was observed against &lt;i&gt;Salmonella enterica&lt;/i&gt;, &lt;i&gt;Listeria monocytogenes&lt;/i&gt;, and &lt;i&gt;Bacillus cereus&lt;/i&gt;. When applied to refrigerated minced chicken meat at concentrations of 1.3% and 2.6%, &lt;i&gt;Am&lt;/i&gt;EA significantly delayed microbial growth, lipid and protein oxidation, and sensory deterioration over 14 days of storage at 4°C. The 2.6% treatment maintained aerobic plate counts below the spoilage threshold, reduced TBARS to 1.14 ± 0.05 mg MDA/kg, limited metmyoglobin formation to 33.65%, and preserved sulfhydryl content at 54.6 µmol/g protein. Sensory acceptability remained above the rejection limit throughout storage, extending shelf life by 4–7 days compared to untreated samples. A machine-learning-based shelf-life prediction framework was further developed and validated on an independent test set, comparing a random forest (RF) algorithm against Support Vector Regression and Multiple Linear Regression baselines. The RF model achieved the best predictive performance, outperforming both alternative algorithms and confirming its ability to capture the nonlinear degradation dynamics of the meat system. Shapley Additive Explanations analysis identified lipid oxidation (thiobarbituric acid reactive substances) and aerobic plate counts as the primary predictors of shelf-life reduction, followed by psychrotrophic bacterial counts and protein oxidation markers, a hierarchy corroborated by predicted-versus-observed, residual, and confusion-matrix diagnostics. Together, these chemical, microbiological, sensory, and AI-validated findi","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149047944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIRS Coupled With Machine Learning Algorithms for the Authentication and Quality Assessment of Indigenous Cattle and Buffalo Meat","authors":"Dip Ghosh,&nbsp;Raad Al Deen,&nbsp;Md. Abul Hashem","doi":"10.1002/efd2.70206","DOIUrl":"https://doi.org/10.1002/efd2.70206","url":null,"abstract":"<p>Ensuring the authenticity of high-value indigenous meats such as cattle (<i>Bos indicus</i>) and water buffalo (<i>Bubalus bubalis</i>) has gained heightened attention as a result of frequent adulteration in global supply chains. This study established a rapid, non-destructive authentication framework comparing physicochemical profiling and portable near-infrared spectroscopy (NIRS) combined with machine learning (ML). Forty <i>longissimus thoracis et lumborum</i> samples (<i>n</i> = 20/species) were analyzed for pH, color (<i>L</i>*, <i>a</i>*, <i>b</i>*), water-holding capacity, drip loss, cooking loss, and shear force. A total of 4000 NIR spectra (700–1100 nm) were acquired using a handheld spectrometer. Buffalo samples exhibited significantly higher shear force (77.82 N), cooking loss (32.56%), and redness (<i>a</i>* = 20.92) than cattle (<i>p</i> &lt; 0.001). NIRS analysis revealed distinct absorbance peaks in buffalo in the O–H (900–980 nm) and C─ H/N─H (750–850, 1060–1088 nm) regions. ML models, including XGBoost and a 1D convolutional neural network, achieved 98.12% and 98.4% accuracy, respectively. SHAP analysis identified 1075.30 nm as a key differentiating wavelength associated with protein and moisture. However, further validation using larger and more diverse sample sets, external test datasets, and intentional adulteration scenarios is required before confirming its broader applicability for routine authentication and fraud detection.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinensetin From Citrus Peel Alleviates LPS-Induced Acute Pneumonia by Regulating HIF-1α Signaling Pathway in Mice","authors":"Zuomin Hu,&nbsp;Yuchi Wu,&nbsp;Feijun Luo,&nbsp;Zhongxing Chu,&nbsp;Yongpan Huang,&nbsp;Jiali Ren,&nbsp;Zhengwen Li,&nbsp;Dandan Qin,&nbsp;Yiping Tang,&nbsp;Yaping Zhou","doi":"10.1002/efd2.70203","DOIUrl":"https://doi.org/10.1002/efd2.70203","url":null,"abstract":"<p>Sinensetin, a key bioactive constituent of citrus peel, exhibits potent anti-inflammatory properties. However, the mechanism by which SIN alleviates acute pneumonia remains unclear. This study established lipopolysaccharide (LPS)-induced acute pneumonia models in vivo and in vitro. Sinensetin administration for 3 days significantly attenuated LPS-induced acute pneumonia in mice, reducing lung injury, oxidative stress, and inflammation. Transcriptomic analysis implicated that sinensetin might improve acute pneumonia by modulating the HIF-1 signaling pathway. Western blotting revealed that sinensetin suppressed HIF-1α expression and phosphorylation of MAPK (p38, ERK1/2, JNK) in lung tissue. In LPS-stimulated BEAS-2B cells, sinensetin mitigated morphological damage and ROS accumulation while inhibiting NF-κB and AP-1 transcriptional activity. At the protein level, sinensetin reduced inflammatory factor expression, correlating with diminished HIF-1α levels and MAPK phosphorylation. Crucially, HIF-1α overexpression reversed the inhibitory effects of sinensetin on inflammatory factors and MAPK signaling. Collectively, these findings demonstrate that sinensetin alleviates acute pneumonia by regulating the HIF-1α pathway.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Compounds and Cytotoxicity of Seed and Leaf Oils of Moringa oleifera","authors":"Emanuela de Lima Viana,&nbsp;Julia da Costa Santos,&nbsp;Ana Caroline de Medeiros Dantas,&nbsp;David Henrique Xavier Barbosa,&nbsp;Matheus de Freitas Fernandes Pedrosa,&nbsp;Pablo Felipe Ferreira Farias,&nbsp;Susana Margarida Gomes Moreira,&nbsp;Patrícia Prado Augusto,&nbsp;Patricia Santos Lopes,&nbsp;Ana Paula Barreto Gomes,&nbsp;Rui de Oliveira Macedo,&nbsp;Francisco Canindé de Sousa Júnior,&nbsp;Cristiane Fernandes de Assis","doi":"10.1002/efd2.70193","DOIUrl":"https://doi.org/10.1002/efd2.70193","url":null,"abstract":"<p><i>Moringa oleifera</i> is a plant known for its bioactive properties and the potential of its oils for food, cosmetic, and pharmaceutical applications. This study evaluated the physicochemical, bioactive properties, and cytotoxicity effect in cells of <i>Moringa oleifera</i> seed and leaf oils. The oils had high levels of unsaturated fatty acids (70.9% in the seed and 70.6% in the leaf), with a predominance of linoleic acid. Both showed no cytotoxicity, with cell viability of over 70% in CHO-K1 and HepG2 cells, but in HaCaT cells, the seed oil presented toxicity at a high concentration of 50 µg·mL⁻¹. Analysis of the phenolic profile showed a higher concentration of eugenol in both oils analyzed, with 864.80 and 787.64 µg·g⁻¹ for the seed and leaf oils, respectively. The methanolic fractions showed higher antioxidant activity. The oils showed an antifungal effect against <i>Candida albicans</i> with minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 10 mg·mL⁻¹. The whole fraction stood out regarding enzyme inhibition, reaching up to 97.94% for α-glucosidase. The results demonstrate the potential of <i>Moringa oleifera</i> oils for industrial applications, highlighting their antioxidant, antifungal, and enzyme inhibitory activity related to carbohydrate metabolism.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Drying Methods on the Physicochemical Properties and Flavor Profile of Chaenomeles speciosa (Sweet) Nakai","authors":"Houyu Kang,&nbsp;Hong Quan,&nbsp;Qiaojun Cai,&nbsp;Xiaozhong Lan,&nbsp;Xinbo Guo","doi":"10.1002/efd2.70189","DOIUrl":"https://doi.org/10.1002/efd2.70189","url":null,"abstract":"<p>This study presents a comparative assessment of the effects of various drying treatments on the physicochemical properties and flavor quality of <i>Chaenomeles speciosa</i> (<i>C. speciosa</i>). In a systematic comparison, a detailed comparison was conducted among samples treated with hot-air drying (HAD) at 100°C, vacuum freeze-drying (VFD), and vacuum drying (VD) across a range of temperatures (60°C–120°C). Results showed that VFD and VD effectively inhibited sample browning. VD at 80°C (VD-80) better preserved total sugars and organic acids (TSOA) compared to other drying methods. Moreover, VD-80 significantly increased both total phenolic content (TPC) and superoxide dismutase activity (SOD), and notably enhanced the content of catechin, the primary phenolic component. In terms of flavor, VD-treated samples developed a predominant aldehydic and floral-like aroma, contributing to a favorable sensory profile. Overall, VD-80 effectively maintains the visual quality of <i>C. speciosa</i> while enhancing its antioxidant properties, offering a practical industrial processing method that balances product quality with bioactive retention.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Lactic Acid Bacteria Fermentation on the Nutritional and Sensory Quality of Arthrospira platensis Beverages","authors":"Hasim Kelebek,&nbsp;Turkan Uzlasir,&nbsp;Pınar Kadiroglu,&nbsp;Hatice Kübra Sasmaz,&nbsp;Serkan Selli,&nbsp;Matteo Bordiga","doi":"10.1002/efd2.70197","DOIUrl":"https://doi.org/10.1002/efd2.70197","url":null,"abstract":"<p><i>Arthrospira platensis</i>, despite its high protein content and valuable micronutrients, faces limited consumer acceptance due to its strong seaweed-like aroma. In this study, laboratory-grown (L) and commercial (C) samples were fermented with <i>Lactiplantibacillus plantarum</i> (LP), <i>Lactobacillus acidophilus</i> (LA), and their mixture (Mix) to reduce undesirable aroma characteristics. Fermentation increased the total amino acid content by 25%–65%, especially enriching glutamic and aspartic acids. Headspace-SPME-GC/MS analysis revealed, for the first time, the presence of <span>d</span>-limonene, styrene, and 1-phenyl-1-butene, highlighting significant volatile biotransformations. Among the strains, <i>L. plantarum</i> most effectively enhanced umami taste, reduced off-odours, and achieved the highest sensory acceptability scores. Furthermore, elevated levels of lactic, acetic, and gluconic acids contributed to improved nutritional and flavor properties. Overall, this study demonstrates that probiotic fermentation of <i>A. platensis</i> allows the development of functional beverages with enhanced nutritional value, better sensory qualities, and a broader volatile profile. To our knowledge, this is the first report documenting both strain-specific amino acid enrichment and novel volatile formation in LAB-fermented <i>A. platensis</i> beverages.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Profiles, Pharmacological Insights, and In Silico Studies of Antidesma montanum Blume: An Experimental and Computer-Aided Approach","authors":"Naureen Banu,&nbsp;Najmul Alam,&nbsp;Sadia Farid Jhuma,&nbsp;Mohammad Nazmul Islam,&nbsp;Shady A. Alghazali,&nbsp;Md Abdul Awal,&nbsp;Sanjida Islam,&nbsp;Hafsa Siddiqua,&nbsp;Shafinaz Nur,&nbsp;Md. Sohel Rana","doi":"10.1002/efd2.70198","DOIUrl":"https://doi.org/10.1002/efd2.70198","url":null,"abstract":"<p><i>Antidesma montanum</i>, an edible wild plant, exhibits significant nutraceutical and pharmacological potential. In this study, the methanol extract of <i>A. montanum</i> (MEAM) was analyzed qualitatively and quantitatively to identify phytochemical constituents, including bioactive metabolites confirmed through GC–MS analysis. The study evaluated its anthelmintic, anxiolytic, antidepressant, and antidiarrheal properties using in vitro, in vivo, and in silico approaches. Anthelmintic activity was tested against <i>Tubifex tubifex</i>, while behavioral assays—open field (OFT), hole cross (HCT), hole board (HBT), elevated plus maze, forced swim (FST), and tail suspension (TST) tests—were performed to assess neuropharmacological effects. MEAM at doses of 200 and 400 mg/kg produced significant (<i>p</i> &lt; 0.001) anxiolytic and antidepressant responses. Additionally, castor oil–induced diarrhea and gastrointestinal motility assays demonstrated dose-dependent antidiarrheal efficacy. Molecular Docking of identified compounds revealed strong binding affinities to respective target receptors, supporting experimental results. Notably, alpha-tocopheryl acetate, deoxycytidine, and vitamin E showed the highest docking scores. ADMET analyses confirmed the drug-likeness and safety of the compounds. Overall, the findings indicate that <i>A. montanum</i> possesses diverse pharmacological activities, highlighting its potential as a valuable source of bioactive agents for nutraceutical and pharmaceutical applications.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Staphylococcus aureus Biofilm Formation by Plumbagin Combined With Ceftazidime and Cefazolin","authors":"Borel Ndezo Bisso,&nbsp;Humera Jahan,&nbsp;Akim Socohou,&nbsp;Mamadou Sawadogo,&nbsp;Jean Paul Dzoyem,&nbsp;M. Iqbal Choudhary","doi":"10.1002/efd2.70194","DOIUrl":"https://doi.org/10.1002/efd2.70194","url":null,"abstract":"<p>Biofilm-forming <i>Staphylococcus aureus</i> is the major cause several foodborne diseases, and pose a serious challenge in the healthcare, and food industry. Therefore, safe and effective antibiofilm strategies are needed to inhibit bacterial attachment in the food processing as well as for the treatment of infections. In the current study, we investigated the synergistic effect of plumbagin with ceftazidime, and cefazoline against biofilm formation by <i>S. aureus</i>. Plumbagin combined with ceftazidime, and cefazoline, had exhibited synergistic bactericidal effect on <i>S. aureus</i>, inhibiting over 80% of the biofilm formation, and reduced over 3 log₁₀ CFU/mL of bacterial cells, as compared to individual compounds. Scanning electron microscopy (SEM) images indicated that the combination of plumbagin with ceftazidime, and cefazolin, strongly inhibited the adherent cells of <i>S. aureus</i>. The amount of exopolysaccharides significantly decreased (<i>p</i> &lt; 0.001) by treatment with plumbagin-ceftazidime and cefazolin-plumbagin combinations, whereas, the amount of exopolysaccharides production reduced to 28.29 μg glucose/mg biofilm, and 22.65 μg glucose/mg biofilm, respectively, as compared to untreated cells (65 μg glucose/mg biofilm). Furthermore, plumbagin in combination with cefazolin, significantly inhibited eDNA, and increased the production of reactive oxygen species (ROS) in <i>S. aureus</i> cells. This led to our finding suggests that these combinations can be used in food industry as well as in the treatment of infections.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physapubescin B From Physalis: A Food-Derived Withanolide for Cancer Chemoprevention and Nutraceutical Development","authors":"Wojciech Koch,&nbsp;Katarzyna Stępnik,&nbsp;Anna Wawruszak,&nbsp;Estera Okoń,&nbsp;Agata Jarząb,&nbsp;Katarzyna Gaweł-Bęben,&nbsp;Magdalena Michalak-Tomczyk,&nbsp;Jacek Jachuła,&nbsp;Magdalena Zdziebło,&nbsp;Paweł Helon,&nbsp;Javad Sharifi-Rad,&nbsp;Daniela Calina","doi":"10.1002/efd2.70196","DOIUrl":"https://doi.org/10.1002/efd2.70196","url":null,"abstract":"<p>Physapubescins are secondary metabolites from the genus <i>Physalis</i> that have been associated with multiple health-related activities, including anticancer, anti-inflammatory, antibacterial, and anti-ischemic effects. Among the identified derivatives (A, B, C, E, F, G, H, I, K), Physapubescin B (PB) has received the greatest attention, yet its anticancer potential has not been fully defined. This review summarizes current evidence on PB and related derivatives, including in vitro and in vivo anticancer activity, mechanistic pathways, combination strategies with anticancer agents, and available information on toxicity, safety, and side effects. A comprehensive literature search was conducted using Scopus, PubMed, Web of Science, and Google Scholar. Across studies, PB and its derivatives showed anticancer activity against several tumor types (including prostate, breast, gastric, and renal cancers), with reported mechanisms such as induction of apoptosis and suppression of cell viability and proliferation. In vivo data, although limited, indicate reduced tumor growth accompanied by decreased vascularization and vessel density. However, the evidence base remains dominated by cell-line studies, with relatively few animal investigations and no human studies to date. Further rigorous preclinical work is required to clarify pharmacokinetics, safety, and translational feasibility before clinical evaluation.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}