eFood最新文献 - Book学术

Micronization of Whole Grain Flours: Innovative Approaches for Improving Functional Characteristics and Product Performance 全谷物面粉的微粉化：改进功能特性和产品性能的创新方法

IF 5.7

eFood Pub Date : 2026-04-05 DOI: 10.1002/efd2.70139

Diksha Arora, Kamaljit Kaur, Taranpreet Kaur, Julia Sebastian, Seid Reza Falsafi

{"title":"Micronization of Whole Grain Flours: Innovative Approaches for Improving Functional Characteristics and Product Performance","authors":"Diksha Arora, Kamaljit Kaur, Taranpreet Kaur, Julia Sebastian, Seid Reza Falsafi","doi":"10.1002/efd2.70139","DOIUrl":"10.1002/efd2.70139","url":null,"abstract":"Rising consumer demand for nutrient-dense cereal products has renewed interest in whole-grain ingredients, yet the coarse texture and altered functional behavior of whole-grain flours limit their application in many foods. Micronization, the controlled reduction of particle size by mechanical or thermal–mechanical approaches (e.g., ball, jet, roller, cryogenic, ultrafine, and IR-based methods), can modify flour microstructure and molecular organization. This review investigates recent studies on micronization of whole-grain flours, comparing techniques and summarizing their effects on structural, physicochemical, techno-functional, thermal, and rheological properties, and final product quality. It also evaluates benefits and trade-offs (e.g., improved digestibility and bioactive release vs. excessive starch damage and energy costs), and highlights analytical methods and application-specific optimization strategies. Micronization is a promising, sustainable route to reconcile whole-grain nutrition with consumer-acceptable functionality: appropriately reduced particle size enhances hydration, pasting behavior, bioactive release, and dough handling, improving texture and shelf life in many applications. However, over-micronization can increase damaged starch, weaken starch–protein networks, and impair product quality, so process parameters must be tailored to grain type and intended use. Future work should prioritize scale-up, combined modification strategies (e.g., enzymatic or hydrothermal pairing), and targeted studies of digestibility and glycemic response to fully realize micronization's potential.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Bread Development With Cocoa Shell Powder: Nutritional, Phytochemical, Antioxidant, and Microbiological Properties 可可壳粉功能性面包的开发：营养、植物化学、抗氧化和微生物特性

IF 5.7

eFood Pub Date : 2026-04-05 DOI: 10.1002/efd2.70146

Mohamed Esam Rozek, Emmanuel Duah Osei, Anthony Amotoe-Bondzie, Marcela Slukova, Ivona Jančo, Eva Ivanišová, Miroslava Kačániová, Newlove Akowuah Afoakwah

{"title":"Functional Bread Development With Cocoa Shell Powder: Nutritional, Phytochemical, Antioxidant, and Microbiological Properties","authors":"Mohamed Esam Rozek, Emmanuel Duah Osei, Anthony Amotoe-Bondzie, Marcela Slukova, Ivona Jančo, Eva Ivanišová, Miroslava Kačániová, Newlove Akowuah Afoakwah","doi":"10.1002/efd2.70146","DOIUrl":"10.1002/efd2.70146","url":null,"abstract":"Cocoa shell powder (CSP), an underutilized agro-industrial byproduct often discarded, contributes to waste and economic losses but holds potential for product development. This study explored the use of CSP for wheat-based bread development. Bread was prepared with 0%, 5%, 7.5%, and 10% CSP substitution and evaluated its proximate composition, mineral and potentially toxic metals, phytochemicals, antioxidant activity, microbial load, and antimicrobial properties. The enriched bread had improved fat (1.69%–3.57%), protein (11.46%–11.78%), dietary fiber (8.61%–9.70%), ash (0.75%–1.09%), and key minerals (Ca, K, Mg, Zn, Cu). Toxic elements, including mercury, lead, arsenic, and cadmium, were not detected in any of the bread samples. CSP addition significantly (p < 0.05) resulted in a dose-dependent increase in total polyphenols (138.0–218.0 mg GAE/100 g), flavonoids (85.0–142.0 mg QE/100 g), antioxidant activity and phenolic acid content. The bread samples showed antimicrobial activity against the tested microbes, with a more pronounced inhibitory effect on Pseudomonas aeruginosa. CSP at 7.5%–10% reduced total plate count, coliforms, and yeast/molds, and supported lactic acid bacteria growth. These findings show that CSP enhances the nutritional and functional qualities of bread while serving as an antimicrobial ingredient. The innovative application of CSP in product development underscores its potential for sustainable valorization of cocoa by-products, supporting circular economy principles and enhancing food quality and environmental sustainability.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147667994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary Evaluation on the Anti-Osteoporosis Mechanism of Sojae Semen Germinatum Based on Network Pharmacology and Germination-Improved Bioavailability 基于网络药理学和发芽改善生物利用度的大豆精抗骨质疏松机制初步评价

IF 5.7

eFood Pub Date : 2026-03-31 DOI: 10.1002/efd2.70145

Rezeye Aili, Hong Chen, Feng Qiu

{"title":"Preliminary Evaluation on the Anti-Osteoporosis Mechanism of Sojae Semen Germinatum Based on Network Pharmacology and Germination-Improved Bioavailability","authors":"Rezeye Aili, Hong Chen, Feng Qiu","doi":"10.1002/efd2.70145","DOIUrl":"10.1002/efd2.70145","url":null,"abstract":"Sojae Semen Germinatum is a processed soybean product germinated using mature seeds of Glycine max (L.) Merr. with therapeutic benefits for osteoporosis. However, its action mechanism and related chemical components are unclear. Therefore, hypothesis-generating methods of network pharmacology and molecular docking were adopted to initially predict the potential mechanism of SSG in treating osteoporosis. Subsequently, experimental validation was performed using mesenchymal stem cell (MSC) proliferation assays to verify the hypothesis. The MSC proliferation-promoting activity of soybean isoflavone aglycones was greater than that of soybean isoflavone glycosides (p < 0.05). Additionally, an LC–ESI–MS/MS method was investigated to confirm the bioavailability of those chemical components after oral administration of SSG and soybean to rats. Only small amounts of free daidzein, glycitein, and genistein were detected in rat plasma, while large amounts of them were detected after being hydrolyzed by β–glucosidase, indicating the main forms of isoflavones were their corresponding phase II metabolites. The bioavailability of total daidzein, glycitein, and genistein increased during soybean germination, reaching 143 ± 30%, 184 ± 32%, and 130 ± 24%, respectively. Soybeans are processed into SSG through germination, which increases the contents of soy isoflavone aglycones, thereby improving their bioavailability and enhancing their therapeutic effect on osteoporosis.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147684298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Antimicrobial–Antioxidant Postbiotics From Lactiplantibacillus plantarum for Clean-Label Meat Preservation 用于清洁标签肉类保鲜的植物乳杆菌双抗微生物-抗氧化后生制剂

IF 5.7

eFood Pub Date : 2026-03-26 DOI: 10.1002/efd2.70140

Florentina Badea, Mircea-Cosmin Pristavu, Filofteia Camelia Diguță, Alexandru Constantin Aldea, Mihaela Dragoi Cudalbeanu, Simona Marcu Spinu, Alina Ortan, Marian Nicolae Verziu, Florentina Matei

{"title":"Dual Antimicrobial–Antioxidant Postbiotics From Lactiplantibacillus plantarum for Clean-Label Meat Preservation","authors":"Florentina Badea, Mircea-Cosmin Pristavu, Filofteia Camelia Diguță, Alexandru Constantin Aldea, Mihaela Dragoi Cudalbeanu, Simona Marcu Spinu, Alina Ortan, Marian Nicolae Verziu, Florentina Matei","doi":"10.1002/efd2.70140","DOIUrl":"10.1002/efd2.70140","url":null,"abstract":"The rising consumer demand for clean-label foods has intensified the search for natural alternatives to synthetic preservatives. Postbiotics from lactic acid bacteria are safe and multifunctional, but their effectiveness in real food systems remains unclear. This study examined the biochemical composition, functional properties, and biopreservation potential of cell-free supernatants (CFSs) produced by two Lactiplantibacillus plantarum strains (MI131 and MI207). Compositional analyses by FTIR, GC–MS, and UHPLC identified diverse bioactive metabolites. GC–MS detected 25 metabolites, with MI131 being more abundant. UHPLC confirmed the presence of phenolic acids and flavonoids, which are known for their antioxidant activity. Antioxidant activity, measured by DPPH assay, was similar for both strains. Antibacterial tests showed strain-specific effects: MI131 exhibited a broader inhibition spectrum, whereas MI207 had lower minimum bactericidal concentrations against Listeria monocytogenes and Salmonella Typhimurium (6.25 mg/mL). Applying CFS to meat stored for 15 days at 4°C reduced viable counts (< 3 log CFU/g) and inhibited pathogens, as confirmed by culture-based methods and qPCR. The results support the use of postbiotics from L. plantarum strains MI131 and MI207 as natural biopreservatives that extend shelf life, promote clean-label formulations, enhance safety, and reduce reliance on synthetic antimicrobials, thereby aligning with EU regulations.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Synergistic Anti-Fatigue Formula Development via Zebrafish Model and Combination Index Method 基于斑马鱼模型和组合指数法的天然协同抗疲劳配方开发

IF 5.7

eFood Pub Date : 2026-03-23 DOI: 10.1002/efd2.70129

Tao Liu, Mengmin Li, Fengqin Feng, Yuanxiang Jin, Zhibin Tian, Bokai Wan, Jintao Cheng, Shiyu Li, Qingchi Wang, Chaozhi Wei, Dou Wang, Kan Shao, Ting Luo, Guiling Yang

{"title":"Natural Synergistic Anti-Fatigue Formula Development via Zebrafish Model and Combination Index Method","authors":"Tao Liu, Mengmin Li, Fengqin Feng, Yuanxiang Jin, Zhibin Tian, Bokai Wan, Jintao Cheng, Shiyu Li, Qingchi Wang, Chaozhi Wei, Dou Wang, Kan Shao, Ting Luo, Guiling Yang","doi":"10.1002/efd2.70129","DOIUrl":"https://doi.org/10.1002/efd2.70129","url":null,"abstract":"Many plant and fungal extracts (PFEs) show anti-fatigue properties through various pathways, but synergistic formulas and mechanisms are unclear. We screened six PFEs using a sodium sulfite (Na2SO3)-induced exercise fatigue zebrafish model and developed a synergistic anti-fatigue formula based on the combination index (CI) method. Red ginseng (RG), Lycium ruthenicum (LR) and Ganoderma lucidum (GL) extracts were selected as formulation materials based on their potential synergistic possibilities. The formula demonstrated a strong synergistic effect on recovery rate with a CI of 0.04 when RG, LR, and GL were mixed at concentrations of 3.6, 4.0, and 14 μg/mL, respectively. Ginsenosides Re, LR anthocyanins and GL polysaccharides are the main anti-fatigue components. The contents of ATP and SOD were increased by 39.1% and 53.9%, while lactic acid and malondialdehyde (MDA) contents were decreased by 31.3% and 15.6%. Zebrafish swimming ability was restored by 97.6% relative to the control group, demonstrating a fatigue recovery effect comparable to that of Red Bull. The formula exerts anti-fatigue effects by regulating muscle contraction, energy metabolism and oxidative stress at the relative rRNA expression. These findings highlight the promising potential of rationally designed PFEs combinations for functional food.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorization of Banana Biomass: Nutritional and Phytochemical Insights With Applications in Food and Allied Industries 香蕉生物量的增值：营养和植物化学的见解与应用在食品和相关工业

IF 5.7

eFood Pub Date : 2026-03-23 DOI: 10.1002/efd2.70143

Bushra Iram Fatima, Saeed Akhtar, Muhammad Zulqarnain Khan, Muhammad Qamar, Tariq Ismail, Wisha Saeed, Elham Assadpour, Tuba Esatbeyoglu, Seid Mahdi Jafari

{"title":"Valorization of Banana Biomass: Nutritional and Phytochemical Insights With Applications in Food and Allied Industries","authors":"Bushra Iram Fatima, Saeed Akhtar, Muhammad Zulqarnain Khan, Muhammad Qamar, Tariq Ismail, Wisha Saeed, Elham Assadpour, Tuba Esatbeyoglu, Seid Mahdi Jafari","doi":"10.1002/efd2.70143","DOIUrl":"https://doi.org/10.1002/efd2.70143","url":null,"abstract":"The global banana processing industry generates substantial organic waste in the form of peels, leaves, stems, and flowers, posing both environmental challenges and opportunities for valorization within a circular economy framework. This review provides a critical and integrative synthesis of the recent literature on nutritional composition, phytochemical diversity, pharmacological potential, food, and non-food applications of various bananas parts with a dedicated focus on safety/toxicity, sustainability, and industrial feasibility. Evidence indicates that banana peels and other underutilized parts are rich in primary and secondary metabolites, supporting their application in functional foods, edible packaging films, animal feed, and also as biofertilizers. Green extraction approaches using ethanol and water emerge as suitable techniques for food grade applications, while organic solvents such as methanol and ethyl acetate for cosmeceutical and pharmaceutical industry. However, the available evidence is primarily based on in vitro studies, animal modeling, and pilot-scale processing. This review concludes that while sustainable upcycling of banana by-products is scientifically justified, it remains translationally limited, necessitating rigorous clinical trials and comprehensive techno-economic evaluations to enable large scale industrial adoption.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorization of Banana Biomass: Nutritional and Phytochemical Insights With Applications in Food and Allied Industries 香蕉生物量的增值：营养和植物化学的见解与应用在食品和相关工业

IF 5.7

eFood Pub Date : 2026-03-23 DOI: 10.1002/efd2.70143

Bushra Iram Fatima, Saeed Akhtar, Muhammad Zulqarnain Khan, Muhammad Qamar, Tariq Ismail, Wisha Saeed, Elham Assadpour, Tuba Esatbeyoglu, Seid Mahdi Jafari

{"title":"Valorization of Banana Biomass: Nutritional and Phytochemical Insights With Applications in Food and Allied Industries","authors":"Bushra Iram Fatima, Saeed Akhtar, Muhammad Zulqarnain Khan, Muhammad Qamar, Tariq Ismail, Wisha Saeed, Elham Assadpour, Tuba Esatbeyoglu, Seid Mahdi Jafari","doi":"10.1002/efd2.70143","DOIUrl":"https://doi.org/10.1002/efd2.70143","url":null,"abstract":"The global banana processing industry generates substantial organic waste in the form of peels, leaves, stems, and flowers, posing both environmental challenges and opportunities for valorization within a circular economy framework. This review provides a critical and integrative synthesis of the recent literature on nutritional composition, phytochemical diversity, pharmacological potential, food, and non-food applications of various bananas parts with a dedicated focus on safety/toxicity, sustainability, and industrial feasibility. Evidence indicates that banana peels and other underutilized parts are rich in primary and secondary metabolites, supporting their application in functional foods, edible packaging films, animal feed, and also as biofertilizers. Green extraction approaches using ethanol and water emerge as suitable techniques for food grade applications, while organic solvents such as methanol and ethyl acetate for cosmeceutical and pharmaceutical industry. However, the available evidence is primarily based on in vitro studies, animal modeling, and pilot-scale processing. This review concludes that while sustainable upcycling of banana by-products is scientifically justified, it remains translationally limited, necessitating rigorous clinical trials and comprehensive techno-economic evaluations to enable large scale industrial adoption.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragalus Polysaccharide Improved DSS-Induced Colitis in Mice By Remodeling the Gut Microbiota 黄芪多糖通过重塑肠道菌群改善dss诱导的小鼠结肠炎

IF 5.7

eFood Pub Date : 2026-03-23 DOI: 10.1002/efd2.70141

Israr Khan, Yanrui Bai, Junxiang Li, Ziyuan Wang, Zhiming Xu, Tao Yuan, Xiangyuan Liu, Yu Zhang, Chunjiang Zhang, Shu Xu

{"title":"Astragalus Polysaccharide Improved DSS-Induced Colitis in Mice By Remodeling the Gut Microbiota","authors":"Israr Khan, Yanrui Bai, Junxiang Li, Ziyuan Wang, Zhiming Xu, Tao Yuan, Xiangyuan Liu, Yu Zhang, Chunjiang Zhang, Shu Xu","doi":"10.1002/efd2.70141","DOIUrl":"https://doi.org/10.1002/efd2.70141","url":null,"abstract":"Gut microbiota has become a key therapeutic target for inflammatory bowel disease (IBD). Astragalus polysaccharides (AP), the main active components of Astragalus membranaceus, can prevent experimental colitis, but their mechanisms remain unclear. This study investigated the therapeutic effect of AP on DSS-induced colitis and its mechanism of attenuation. AP significantly improved colitis by increasing body weight and colon length, reducing histological injury, and lowering the disease activity index (DAI). AP inhibited proinflammatory cytokines (IL-6, IL-17A, IL-22, IL-23), upregulated anti-inflammatory cytokines (IL-10, TGF-β) in colon tissue, and increased fecal SCFA levels. AP also reshaped gut microbiota by decreasing Proteobacteria, Verrucomicrobia, Allobaculum, Turicibacter, and Akkermansia, while enriching Firmicutes, Bacteroidetes, Lactobacillus, Lachnospiraceae, Ruminococcus, and Oscillospira. These enriched genera positively correlated with IL-10, TGF-β, and SCFAs, and negatively with IL-6, IL-17A, and IL-23. KEGG analysis showed that AP restored metabolic pathways disrupted during colitis. Overall, AP protected against DSS-induced colitis by modulating gut microbial composition, metabolism, and immune responses. Importantly, ABX + AP experiments confirmed that the therapeutic effect of AP depends on gut microbiota. These findings indicate that AP alleviates colitis by remodeling the gut microbiota and may serve as a promising microbiome-based therapy for ulcerative colitis.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Synergistic Anti-Fatigue Formula Development via Zebrafish Model and Combination Index Method 基于斑马鱼模型和组合指数法的天然协同抗疲劳配方开发

IF 5.7

eFood Pub Date : 2026-03-23 DOI: 10.1002/efd2.70129

Tao Liu, Mengmin Li, Fengqin Feng, Yuanxiang Jin, Zhibin Tian, Bokai Wan, Jintao Cheng, Shiyu Li, Qingchi Wang, Chaozhi Wei, Dou Wang, Kan Shao, Ting Luo, Guiling Yang

{"title":"Natural Synergistic Anti-Fatigue Formula Development via Zebrafish Model and Combination Index Method","authors":"Tao Liu, Mengmin Li, Fengqin Feng, Yuanxiang Jin, Zhibin Tian, Bokai Wan, Jintao Cheng, Shiyu Li, Qingchi Wang, Chaozhi Wei, Dou Wang, Kan Shao, Ting Luo, Guiling Yang","doi":"10.1002/efd2.70129","DOIUrl":"https://doi.org/10.1002/efd2.70129","url":null,"abstract":"Many plant and fungal extracts (PFEs) show anti-fatigue properties through various pathways, but synergistic formulas and mechanisms are unclear. We screened six PFEs using a sodium sulfite (Na2SO3)-induced exercise fatigue zebrafish model and developed a synergistic anti-fatigue formula based on the combination index (CI) method. Red ginseng (RG), Lycium ruthenicum (LR) and Ganoderma lucidum (GL) extracts were selected as formulation materials based on their potential synergistic possibilities. The formula demonstrated a strong synergistic effect on recovery rate with a CI of 0.04 when RG, LR, and GL were mixed at concentrations of 3.6, 4.0, and 14 μg/mL, respectively. Ginsenosides Re, LR anthocyanins and GL polysaccharides are the main anti-fatigue components. The contents of ATP and SOD were increased by 39.1% and 53.9%, while lactic acid and malondialdehyde (MDA) contents were decreased by 31.3% and 15.6%. Zebrafish swimming ability was restored by 97.6% relative to the control group, demonstrating a fatigue recovery effect comparable to that of Red Bull. The formula exerts anti-fatigue effects by regulating muscle contraction, energy metabolism and oxidative stress at the relative rRNA expression. These findings highlight the promising potential of rationally designed PFEs combinations for functional food.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragalus Polysaccharide Improved DSS-Induced Colitis in Mice By Remodeling the Gut Microbiota 黄芪多糖通过重塑肠道菌群改善dss诱导的小鼠结肠炎

IF 5.7

eFood Pub Date : 2026-03-23 DOI: 10.1002/efd2.70141

Israr Khan, Yanrui Bai, Junxiang Li, Ziyuan Wang, Zhiming Xu, Tao Yuan, Xiangyuan Liu, Yu Zhang, Chunjiang Zhang, Shu Xu

{"title":"Astragalus Polysaccharide Improved DSS-Induced Colitis in Mice By Remodeling the Gut Microbiota","authors":"Israr Khan, Yanrui Bai, Junxiang Li, Ziyuan Wang, Zhiming Xu, Tao Yuan, Xiangyuan Liu, Yu Zhang, Chunjiang Zhang, Shu Xu","doi":"10.1002/efd2.70141","DOIUrl":"https://doi.org/10.1002/efd2.70141","url":null,"abstract":"Gut microbiota has become a key therapeutic target for inflammatory bowel disease (IBD). Astragalus polysaccharides (AP), the main active components of Astragalus membranaceus, can prevent experimental colitis, but their mechanisms remain unclear. This study investigated the therapeutic effect of AP on DSS-induced colitis and its mechanism of attenuation. AP significantly improved colitis by increasing body weight and colon length, reducing histological injury, and lowering the disease activity index (DAI). AP inhibited proinflammatory cytokines (IL-6, IL-17A, IL-22, IL-23), upregulated anti-inflammatory cytokines (IL-10, TGF-β) in colon tissue, and increased fecal SCFA levels. AP also reshaped gut microbiota by decreasing Proteobacteria, Verrucomicrobia, Allobaculum, Turicibacter, and Akkermansia, while enriching Firmicutes, Bacteroidetes, Lactobacillus, Lachnospiraceae, Ruminococcus, and Oscillospira. These enriched genera positively correlated with IL-10, TGF-β, and SCFAs, and negatively with IL-6, IL-17A, and IL-23. KEGG analysis showed that AP restored metabolic pathways disrupted during colitis. Overall, AP protected against DSS-induced colitis by modulating gut microbial composition, metabolism, and immune responses. Importantly, ABX + AP experiments confirmed that the therapeutic effect of AP depends on gut microbiota. These findings indicate that AP alleviates colitis by remodeling the gut microbiota and may serve as a promising microbiome-based therapy for ulcerative colitis.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0