eFood最新文献

{"title":"Bioavailability and Bioaccessibility of Grain Polyphenols: A Comprehensive Review","authors":"Fatima Tariq,&nbsp;Fakhar Islam,&nbsp;Bushra Atique,&nbsp;Ahmed Hussien Alawadi,&nbsp;Subbulakshmi Ganesan,&nbsp;Sana Attique,&nbsp;Ashish Singh Chauhan,&nbsp;Ali Imran,&nbsp;Mohd Asif Shah,&nbsp;Hafiz A. R. Suleria","doi":"10.1002/efd2.70067","DOIUrl":"https://doi.org/10.1002/efd2.70067","url":null,"abstract":"<p>Phenolic compounds are highly abundant, heterogeneous substances in plant food sources, especially grains. Wheat contains chlorogenic acid, syringic acid, ferulic acid, and gallic acid, and oats contain polyphenolic compounds such as <i>p</i>-hydroxybenzoic acid, caffeic acid, syringic acid, vanillic acid, and <i>p</i>-coumaric acid. Corn also consists of <i>p</i>-coumaric acid, <i>o</i>-coumaric acid, and gallic acid. Phenols are considered therapeutic agents related to the treatment and treatment of various diseases such as cardiovascular diseases, neurological disorders, cancer, diabetes, Parkinson's, and Alzheimer's, as well as the reduction of anthropometric parameters. Fermentation is used to increase the bioavailability of polyphenols and improve microbial ecology. Encapsulation has recently been ranked as the most effective method for optimal stability and bioavailability of active ingredients. This review explores the role of grain phenolic compounds in bioavailability and bioaccessibility in detail.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halymenia durvillei Extracts Exert Antiobesity Effects by Targeting hosl-1-Mediated Lipolysis in a Glucose-Induced Caenorhabditis elegans Model","authors":"Kawita Chumphoochai,&nbsp;Sukrit Promtang,&nbsp;Pawanrat Chalorak,&nbsp;Preeyanuch Manohong,&nbsp;Nakorn Niamnont,&nbsp;Montakan Tamtin,&nbsp;Prasert Sobhon,&nbsp;Simon Tuck,&nbsp;Krai Meemon","doi":"10.1002/efd2.70065","DOIUrl":"https://doi.org/10.1002/efd2.70065","url":null,"abstract":"<p>The antiobesity effect of extracts from the marine algae, <i>Halymenia durvillei</i> (HD), was investigated in a glucose-induced <i>Caenorhabditis elegans</i> model of obesity. Total fat accumulation, triglyceride levels, lifespan, intracellular ROS levels, and the potential mechanism of action of <i>H. durvillei</i> extracts were examined. The present study demonstrated that the ethanol fraction of <i>H. durvillei</i> (HDET) and ethyl acetate fraction of <i>H. durvillei</i> (HDEA) extracts led to a significant reduction in fat accumulation, triglyceride levels, the GFP-labeled <i>dhs-3</i>, a marker for lipid droplets, and the intracellular ROS levels. <i>H. durvillei</i> extracts significantly extended the lifespan of glucose-induced worms. In addition, the mRNA expression of lipolysis-related genes, <i>atgl-1</i> and <i>hosl-1</i>, showed significant upregulation following treatment with <i>H. durvillei</i> extracts. This finding was supported by RNA interference (RNAi) of <i>atgl-1</i> and <i>hosl-1</i>, which resulted in disrupting the effect of the <i>H. durvillei</i> extracts on lowering fat accumulation. Furthermore, transcriptomic analysis revealed diverse metabolic activities in glucose-induced worms treated with HDEA, affecting fatty acid metabolism. The results suggested that these extracts provide an antiobesity effect mediated through the lipolysis genes, <i>atgl-1</i> and <i>hosl-1</i>. <i>H. durvillei</i>-derived extracts may offer valuable insights as functional food ingredients for use in the prevention of obesity.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory and Antioxidant Activities of Polyphenols From Loquat (Eriobotrya japonica Lindl.) Leaf Hair in Lipopolysaccharide-Induced In Vitro and In Vivo Models","authors":"Can Hu,&nbsp;Jiazheng Hu,&nbsp;Hongyu Ye,&nbsp;Mengxin Wang,&nbsp;Manxi Wu,&nbsp;Han Yang,&nbsp;Kang Chen,&nbsp;Jinping Cao,&nbsp;Yanshuai Wang,&nbsp;Yue Wang,&nbsp;Chongde Sun","doi":"10.1002/efd2.70064","DOIUrl":"https://doi.org/10.1002/efd2.70064","url":null,"abstract":"<p>This study aimed to characterize polyphenols present in Loquat (<i>Eriobotrya japonica</i> Lindl.) leaf hair (LLH) and evaluate their antioxidant and anti-inflammatory effects in lipopolysaccharide (LPS)-induced inflammation models In Vitro and In Vivo. Ultra-performance liquid chromatography coupled with UPLC-HRMS identified 24 compounds in LLH, including 21 polyphenols, notably revealing the presence of four polymethoxyflavones previously unreported in loquat. Antioxidant evaluations (ABTS, DPPH, FRAP, and ORAC) confirmed robust radical-scavenging and reducing capabilities of LLH extract. In Vitro studies utilizing human liver L02 cells demonstrated that LLH significantly suppressed LPS-induced reactive oxygen species (ROS) generation, preserved antioxidant enzyme activities (CAT, SOD, and GSH-Px), and upregulated antioxidant-related genes (<i>Nrf2</i>, <i>Cat</i>, <i>Sod1</i>, and <i>Gpx1</i>). Furthermore, LLH pretreatment markedly inhibited LPS-induced nitric oxide (NO) release, inflammatory cytokine (IL-1β, IL-6, and TNF-α) production, and downregulated the Jak2–Stat3 inflammatory signaling pathway. Consistently, In Vivo experiments using an LPS-induced acute liver injury mouse model revealed that oral administration of LLH significantly reduced hepatic oxidative stress and inflammation by restoring antioxidant enzyme activities, enhancing <i>Nrf2</i>-mediated antioxidant pathways, and suppressing inflammatory mediators and Jak2–Stat3 signaling in liver. Collectively, these findings demonstrate LLH polyphenols' potent antioxidant and anti-inflammatory effects and suggest their potential as natural functional agents for managing inflammation-related oxidative stress.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Yunnan Guangnan Dendrobium officinale With Different Growth Years Using UHPLC–Orbitrap–MS","authors":"Jiao Zhang,&nbsp;Yanping Ye,&nbsp;Yan Ding,&nbsp;Heng Tian,&nbsp;Xinglian Chen,&nbsp;Kaixi Li,&nbsp;Hongcheng Liu,&nbsp;Tao Lin","doi":"10.1002/efd2.70066","DOIUrl":"https://doi.org/10.1002/efd2.70066","url":null,"abstract":"<p><i>Dendrobium officinale</i> from Guangnan was screened nontargeted using UHPLC–Orbitrap-MS for different growth years. OPLS-DA effectively differentiated <i>D. officinale</i> based on growth years, identifying 70 different compounds. Eight indole diketopiperazine alkaloids did not differ considerably among the growth years. The differential compounds of <i>D. officinale</i> with 4 years of growth were more distinct from other years, with 10 compounds showing greater variability. Pathways in cancer, cancer metabolic pathways, metabolic pathways, chemical carcinogenesis—receptor activation were more enriched. This suggests that <i>D. officinale</i> functional compounds have pharmacological activities in these areas and can regulate the metabolic processes of lipids and atherosclerosis.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Circulating Fatty Acid Profiles With Cardiovascular and All-Cause Mortality in the General Population: A Cohort Study","authors":"Xiaogang Lv,&nbsp;Qianqian Ji,&nbsp;Qi Liu,&nbsp;Qingya Zhao,&nbsp;Yue Xu,&nbsp;Yaxian Meng,&nbsp;Liqiong Zhou,&nbsp;Zhao Hu,&nbsp;Na Wang,&nbsp;Yiqiang Zhan","doi":"10.1002/efd2.70062","DOIUrl":"https://doi.org/10.1002/efd2.70062","url":null,"abstract":"<p>The association between circulating fatty acids (FAs) and mortality remains unclear. This study investigates the association between circulating FA and mortality, focusing on all-cause and cardiovascular disease (CVD) mortality. Using data from 2517 individuals (mean age 48.2 years) in the National Health and Nutrition Examination Survey (2011–2014), we analyzed FA levels and mortality using a weighted Cox proportional hazards model, with sex-stratified analysis. In addition, restricted cubic spline was used to evaluate the FAs and all-cause mortality on a continuous scale. Over 16,660 person-years, 213 deaths occurred, including 73 from CVD. After multivariable adjustment, circulating saturated fatty acids (SFAs; arachidic, docosanoic, tricosanoic, and lignoceric acids) were associated with lower all-cause mortality risk (HR per 1-SD [95% CI]: 0.76 [0.59–0.97], 0.69 [0.56–0.85], 0.63 [0.52–0.77], 0.68 [0.59–0.80], respectively). In contrast, monounsaturated fatty acids (MUFAs; myristoleic, palmitoleic, and cis−Vaccenic acids) were associated with higher all-cause mortality risk (HR per 1-SD [95% CI]: 1.13 [1.04–1.23], 1.18 [1.09–1.27], 1.20 [1.09–1.32], respectively). Similar trends were observed for CVD mortality. <span>l</span>-shaped nonlinear associations indicated that the lowest risk of all-cause mortality occurred at FA concentrations between 25 and 65 μmol/L. These findings highlight the complex relationship between FAs and mortality in US adults.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docosahexaenoic Acid and Nervonic Acid Synergically Enhance Cognitive Memory in Normal Mice via Brain Fatty Acids Remodeling","authors":"Hai-Yan Ou,&nbsp;Lei Feng,&nbsp;Rui-Ye Chen,&nbsp;Hui-Yun Lu,&nbsp;Shuang Cai,&nbsp;Zhi-You Yang","doi":"10.1002/efd2.70059","DOIUrl":"https://doi.org/10.1002/efd2.70059","url":null,"abstract":"<p>Docosahexaenoic acid (DHA) and nervonic acid (NA) are the main components of brain gray and white matter, respectively. Preclinical and clinical studies suggest the effects of DHA or NA supplementation on memory improvement in aging and Alzheimer's disease models. However, it is not yet clear whether dietary supplementation with DHA and NA can enhance memory by increasing their levels in gray and white matter. The present study aimed to examine the spatial memory and brain white and gray matter lipidomic profiles in adolescent mice with or without a DHA and NA-enriched diet. Spatial memory and conditional fear memory were evaluated in adolescent mice using the Morris Water Maze and passive avoidance test beginning at 7-week of age and mice were killed at 13-week of age to allow for the dissection of brain tissues. Combined low dose treatment of DHA (600 mg/kg) and NA (94 mg/kg) synergically enhanced spatial memory and fear memory function, and the effects were better than that of DHA intervention. While, high dose of DHA and NA treatment was detrimental to long-term spatial memory and fear memory, corresponding to the decreased levels of serotonin (5-HT) in the cortex and hippocampus, and imbalanced fatty acids in the white and gray matter. In addition, c-Fos positive neurons were increased in low dose DHA treated mice comparing to that of control mice. Lipidomic analyses suggest levels of NA, dihomo-γ-linolenic acid, EPA, DHA, and linoleic acid were increased in the white matter post low dose of DHA + NA treatment, as well as increased levels of dihomo-γ-linolenic acid, EPA, and DHA in the gray matter compared with control mice. Understanding how DHA and NA supplementation during the adolescent periods affects cognitive function in a dose-specific manner has important implications for determining the dietary requirements of DHA and NA. The present study reported for the first time that DHA and NA combination regulate spatial memory in a dose-specific manner and provides evidence that further research needs to consider how different ratios of DHA and NA regulate the fatty acid composition in white and gray matter, thereby influencing memory function.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Sustainability in Fruit and Vegetable Packaging: The Role of Nanotechnology in Food Preservation","authors":"Farhang Hameed Awlqadr,&nbsp;Ammar B. Altemimi,&nbsp;Ali Muhi Aldeen Omar,&nbsp;Mohammed N. Saeed,&nbsp;Syamand Ahmed Qadir,&nbsp;Aryan Mahmood Faraj,&nbsp;Alaa Jabbar Abd Al-Manhel,&nbsp;Tablo H. Salih,&nbsp;Mohammad Ali Hesarinejad,&nbsp;Italo Rennan Sousa Vieira","doi":"10.1002/efd2.70060","DOIUrl":"https://doi.org/10.1002/efd2.70060","url":null,"abstract":"<p>Food packaging has seen a technological revolution through nanotechnology that provides highly innovative solutions to the increase of preservation, quality, and shelf life of fruits and vegetables. Moreover, this review has an in-depth examination of the most advanced nanotechnology packaging that realizes a significant increase in barrier properties, it is involved in including antimicrobial method, and is a pioneer in making use of intelligent packaging systems. Different nanomaterials, such as nano-coatings, nano-films, and nanofibers have proven their effectiveness in modulating oxygen and moisture permeability and repressing microbial contamination along with systems for real-time environmental monitoring. Furthermore, the incorporation of biodegradable nanocomposite films into the market provides a bio-based alternative to conventional packaging, which is a cheaper and environmentally friendly way of maintaining food safety and freshness. However, despite such developments, it can be seen that there are a number of challenges that still require a bit further probing. The future research should concern the most comprehensive analysis of nanoparticles that migrate from the packaging into the products and how they may affect people in the case of long-term exposure. Moreover, incorporating regulations related to the usage of nanotechnologies should be standardized to ensure that the adoption of nanotechnology in the food packaging process is safe and responsible. Green technology made the innovations in bio-based nanomaterials and eco-friendly nano-coatings become a reality, which further promoted the sustainability of the gains and still brought all the benefits intact. Additionally, integrating smart packaging systems with nanosensors will offer the possibility of food waste reduction and improvement of supply chain efficiency through real-time food quality monitoring. Continued interdisciplinary collaboration between food scientists, material engineers, and regulatory authorities will be crucial to addressing these challenges and unlocking the full potential of nanotechnology in food packaging.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional, Nutraceutical, and Health-Endorsing Perspectives of Ashwagandha","authors":"Muhammad Tayyab Arshad,&nbsp;Sammra Maqsood,&nbsp;Ali Ikram,&nbsp;Muhammed Adem Abdullahi","doi":"10.1002/efd2.70061","DOIUrl":"https://doi.org/10.1002/efd2.70061","url":null,"abstract":"<p>A widely used herb in Ayurvedic medicine, Ashwagandha has garnered much attention from individuals worldwide due to its potential therapeutic and health benefits. This comprehensive review examines the nutritional composition, medicinal benefits, and clinical data related to Ashwagandha's application in modern medicine. Ashwagandha has been used for centuries to treat physical exhaustion, tension, and anxiety, but new research has broadened its medicinal uses. It has many benefits because of its immunomodulatory, anti-inflammatory, adaptogenic, and antioxidant properties. Some of the significant bioactive substances include alkaloids, saponins, and withanolides. The clinical studies have established the benefits of Ashwagandha for mental health, metabolic health, stress reduction, cognitive function, immunity, and cardiovascular health. This review also covers the expanding significance of Ashwagandha in nutrition and its uses in functional foods. Despite promising Ashwagandha-based therapeutics, their science must be developed into standard products, improve the dosing, and eliminate current regulatory hurdles for widespread use.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Oat-Based Postbiotic and Synbiotic Products: Chemical Constituents and Hepatoprotective Efficacy","authors":"Ruixue Wen,&nbsp;Lanqi Zhou,&nbsp;Wei Song,&nbsp;Jiayao Lv,&nbsp;Tianqi Liu,&nbsp;Haizhou Wu,&nbsp;Lin Shi","doi":"10.1002/efd2.70052","DOIUrl":"https://doi.org/10.1002/efd2.70052","url":null,"abstract":"<p>Oat (<i>Avena sativa</i>) is a health-promoting food exhibiting prebiotic properties. We invented oat-based postbiotics (Oat_PB) fermented with probiotics (mainly <i>Lactobacillus</i> and <i>Bifidobacterium</i>) and comprehensively compared their chemical constitutions with the synbiotic form (Oat_SB). Oat_PB accumulated <i>β</i>-glucan, avenanthramides (2c, 2p, and 2f) as well as free amino acids, for example, threonine, valine, arginine, aspartate, citrulline, and taurine, while reducing total phenol, flavone, and protein. Oat_PB enriched metabolites affecting lipid and glucose metabolism. Probiotics-derived oat foods mitigated high-sucrose-induced obesity, liver injury, and repaired lipid and glucose metabolism in rats, with Oat_PB showing most pronounced effects. Oat_PB reversed high-sucrose disturbed hepatic fatty acid profiles, and regulated genes and proteins involved in lipid homeostasis. Oat_PB ameliorated gut dysbacteriosis by increasing <i>Alloprevotella</i>, <i>Prevotella</i>, and <i>Akkermansia</i> while inhibiting harmful bacteria. Collectively, our study demonstrates the additional value of probiotic-derived oat foods beyond the raw oat materials in preventing metabolic homeostasis and gut dysbacteriosis.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Characterization of Morchella esculenta Polysaccharides and Its Ability to Modulate Intestinal Barrier and Intestinal Microbiota in Dextran Sulfate Sodium-Induced Colitis Mice","authors":"Shutong Chen,&nbsp;Bo Teng,&nbsp;Wancong Zhang,&nbsp;Jude Juventus Aweya,&nbsp;Kit-Leong Cheong","doi":"10.1002/efd2.70058","DOIUrl":"https://doi.org/10.1002/efd2.70058","url":null,"abstract":"<p><i>Morchella esculenta</i> polysaccharides (MEPs) are known to have multiple bioactive properties, including immunomodulatory, anticancer, antioxidant, anti-inflammatory, etc. In this study, we assessed the impact of MEPs on dextran sulfate sodium (DSS)-induced colitis in mice, focusing on intestinal barrier and microbiota modulation. Using NMR analysis, MEPs were found to predominantly consist of 1,4,6-<i>α</i>-<span>d</span>-Glc<i>p</i> and 1,4-<i>α</i>-<span>d</span>-Glc<i>p</i>. MEPs were able to significantly alleviate weight loss, reduce colon length shortening, and mitigate colon pathology in mice. Notably, MEPs suppressed elevated pro-inflammatory cytokines levels but boosted anti-inflammatory cytokine levels. Besides, MEPs modulated gut microbiota, enhancing microbial diversity and promoting homeostasis compared to untreated. Furthermore, there was a higher relative abundance of beneficial bacteria, indicating that MEPs could enhance gut microbiota composition. Collectively, MEPs have promising therapeutic potential in preventing colitis, and therefore could be developed as a novel nutraceutical strategy.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}