eFood最新文献

{"title":"Identification of Volatile Odor Compounds in Extracts of Four Types of Herbaceous Plant Spices via GC × GC–O-TOF MS","authors":"Suxing Tuo,&nbsp;Qinghui Jia,&nbsp;Shuang Bi,&nbsp;Yixin Dai,&nbsp;Ting Deng,&nbsp;Hongbing Lu,&nbsp;Jiaxiao Cai,&nbsp;Zifeng Li,&nbsp;Cheng Yang,&nbsp;Kejun Zhong,&nbsp;Bo Kong,&nbsp;Ye Liu","doi":"10.1002/efd2.70191","DOIUrl":"https://doi.org/10.1002/efd2.70191","url":null,"abstract":"<p>To conduct an in-depth exploration of the unique flavors of herbal spices, four spice extracts—sour horn, alfalfa, chicory, and fenugreek—were selected for this study. All four extracts have a long history of use in traditional food applications. In this study, volatile compounds and key odor-active components in the four herbal spice extracts were analyzed using sensory evaluation, electronic nose (E-nose), solid-phase microextraction (SPME), and comprehensive two-dimensional gas chromatography-olfactometry-time-of-flight mass spectrometry (GC×GC-O-TOF MS). The results indicated that the sour horn, alfalfa, chicory, and fenugreek extracts all exhibited flavor profiles characterized by sourness, sweetness, and medicinal notes. A total of 116 volatile odor compounds were identified in the sour horn extract (SHE), 181 in the alfalfa extract (AE), 224 in the chicory extract (CE), and 119 in the fenugreek extract (FE). Across all four herbal spice extracts, 59 odor-active components were collectively detected. Furthermore, the number of substances with rOAV ≥ 1 was determined to be 11 in the SHE, 16 in the AE, 27 in the CE, and 18 in the FE, respectively. This study investigated the odor components of four herbal spices, which will facilitate further in-depth research on spice extracts in the future.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Shipping Factors to Increase the Profitability of Meat E-Commerce","authors":"Paul Olaoluwaniyi Dahunsi,&nbsp;Ximena Osorio,&nbsp;Alan R. Vazquez,&nbsp;Derico Setyabrata","doi":"10.1002/efd2.70190","DOIUrl":"https://doi.org/10.1002/efd2.70190","url":null,"abstract":"<p>This study aimed to identify the impact of multiple shipping factors on beef quality attributes. Boneless striploins (<i>n</i> = 5) were wet-aged to 28 d postmortem, cut into 2.54 cm thick steaks, and randomly assigned to 32 different shipping treatments, representing combinations of six two-level factors: (1) Shipping Container Type (Polystyrene-Foam vs. Biodegradable), (2) Coolant Type (Icepacks vs. Dry-ice), (3) Ambient Temperature (Hot vs. Cold), (4) Shipping duration (1 Day vs. 3 Days), (5) Coolant Load (20% vs. 40%), and (6) Filler Usage (Filler vs. No-filler). Each steak was vacuum-packaged, frozen at –20°C and subjected to simulated shipping conditions. Samples were analyzed for pH, odor, color, cook loss, shear force, lipid oxidation, and microbial concentration. The experiment was replicated 3 times. The results indicated that ambient temperature, filler usage, and shipping duration had significant effects on meat quality (<i>p</i> &lt; 0.05). Coolant and container types were significant only when combined with other factors (<i>p</i> &lt; 0.05). Samples shipped in Hot and 3Days were observed to have higher (<i>p</i> &lt; 0.05) microbial concentrations than their respective counterparts. Greater redness was observed in meat samples shipped with fillers than those without (<i>p</i> &lt; 0.05). The results indicated that ambient temperature and shipping duration greatly influenced the meat quality attributes and suggested opportunities to optimize shipping practices for consumer use.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Evaluation of the Multifunctional Bioactivity of Curcuma zedoaria (Christm.) Roscoe Essential Oil: Antimicrobial, Insecticidal, and Postharvest Effects on Fresh Ginger","authors":"Miroslava Kačániová,&nbsp;Minhang Qiao,&nbsp;Joel Horacio Elizondo-Luevano,&nbsp;Zhaojun Ban,&nbsp;Li Li,&nbsp;Yizhou Gao,&nbsp;Anis Ben Hsouna,&nbsp;Rania Ben Saad,&nbsp;Maciej Ireneusz Kluz,&nbsp;Stefania Garzoli","doi":"10.1002/efd2.70195","DOIUrl":"https://doi.org/10.1002/efd2.70195","url":null,"abstract":"<p>Plant-derived essential oils are increasingly investigated as sustainable alternatives for food preservation and crop protection; however, their multifunctional applicability under postharvest conditions remains insufficiently explored. This study evaluated the integrated antimicrobial, insecticidal, and postharvest preservation potential of <i>Curcuma zedoaria</i> (Christm.) Roscoe essential oil (CZEO) of Chinese origin. GC-MS analysis identified 22 compounds, with curcumenol (26.7%), curzerene (18.5%), β-elemene (13.1%), and curcumenone (12.3%) as the predominant constituents, confirming a sesquiterpenoid-dominant profile. CZEO exhibited antimicrobial activity against all tested microorganisms, with the highest susceptibility observed for <i>Enterococcus faecalis</i> and <i>Staphylococcus aureus</i>. Vapor-phase assays performed on ginger, beetroot, apple, and strawberry matrices demonstrated concentration-dependent inhibition of microbial growth, with the strongest activity observed on the ginger matrix. In a 14-day storage experiment at 4°C, the combined application of CZEO and vacuum packaging most effectively reduced coliform bacteria and total viable counts in fresh ginger. MALDI-TOF MS analysis identified 269 isolates belonging to 26 species, with dominant representation of the genus <i>Pseudomonas</i>. Combined treatment with CZEO and vacuum packaging suppressed several <i>Pseudomonas</i> species associated with postharvest spoilage. CZEO also demonstrated concentration-dependent insecticidal activity against <i>Callosobruchus maculatus</i> and <i>Megabruchidius dorsalis</i>. Overall, this study provides an integrated experimental evaluation of CZEO across antimicrobial, insecticidal, and postharvest systems, highlighting its potential as a natural multifunctional agent for sustainable food preservation and crop protection.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone","authors":"Yi Liu,&nbsp;Ziyong Mao,&nbsp;Jesus Simal-Gandara,&nbsp;Zi Chen,&nbsp;Hui Cao","doi":"10.1002/efd2.70121","DOIUrl":"https://doi.org/10.1002/efd2.70121","url":null,"abstract":"<p>Morelloflavone (MF), a biflavonoid primarily found in <i>Garcinia</i> species, exhibits a wide range of health benefits, including antioxidative, anti-inflammatory, anticancer, anti-obesity, antidiabetic, antimicrobial, anti-atherosclerotic, and neuroprotective effects. MF in exerting these bioactivities is closely linked to the modulation of critical molecular targets. This review provides a comprehensive and current examination of MF sources, physicochemical properties, biosynthesis and synthesis, bioactivities, particularly in cancer and inflammation, safety and toxicological effects of MF, and their underlying molecular mechanisms. In addition to Clusiaceae, MF can also be obtained from Tamaricaceae and Anacardiaceae. MF offers multiple health benefits, including anticancer, anti-inflammatory, antioxidant, antiatherosclerotic, anti-obesity, antidiabetic, anti-metabolic syndrome, antimicrobial, and neuroprotective effects. These benefits stem from its impact on various regulatory mechanisms, including key proteins/enzymes, lipid and glucose metabolism, insulin signaling, ERK signaling, oxidative stress, and regulation of gut microbiota. Moreover, the multi-target nature of MF makes it well-suited for integration with big data and machine learning approaches to identify molecular signatures, predict ligand-target interactions, and prioritize therapeutic pathways. Notably, preliminary clinical trials of MF-containing formulations suggest therapeutic potential, though rigorous clinical trials of pure MF are still needed. Overall, MF shows promise for preventing certain chronic human diseases.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Enzymatic Browning Under Emerging Cooking Technologies: Matrix-Dependent Pathways, Neoformed Compounds, and Nutritional–Toxicological Trade-Offs","authors":"Djilali Benabdelmoumene,&nbsp;Said Dahmouni,&nbsp;Muhammad Waqar,&nbsp;Zineb Bengharbi,&nbsp;Mustapha Kamel Fodil,&nbsp;Noureddine Benguennouna,&nbsp;Wasim S. M. Qadi,&nbsp;Ahmed Mediani","doi":"10.1002/efd2.70192","DOIUrl":"https://doi.org/10.1002/efd2.70192","url":null,"abstract":"<p>Non-enzymatic browning is a central chemical process in thermally processed foods, linking sensory quality, structural development, nutrient modification, and neoformed compound formation. This review examines browning under emerging cooking technologies, including air frying, sous-vide, microwave, ohmic, infrared, radio frequency, pressure-assisted, and hybrid systems. It proposes a reaction-network perspective in which Maillard chemistry interacts with caramelization, ascorbic acid degradation, lipid oxidation-derived carbonyls, and secondary carbonyl–amine reactions. Particular attention is given to matrix-dependent responses across cereal, potato, fruit, vegetables, legume, meat, fish, dairy, and reformulated protein systems, where precursor composition, water mobility, pH, oxygen exposure, lipid unsaturation, and microstructure determining browning direction. The review also highlights the balance between desirable outcomes, including crust formation and roasted aroma, and adverse effects, including lysine loss, impaired digestibility, acrylamide, hydroxymethylfurfural, reactive carbonyls, and advanced glycation end products. Finally, it identifies post-digestion evidence as a missing link for assessing biological relevance.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148466912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Lactobacillus-Mediated Functionalization of Dendrobium officinale Polysaccharides: A Study From Physicochemical Properties and Structural Changes to Anti-Inflammatory Activity","authors":"Dingding Hong,&nbsp;Hui Ye,&nbsp;Xiaojun Huang","doi":"10.1002/efd2.70172","DOIUrl":"https://doi.org/10.1002/efd2.70172","url":null,"abstract":"<p>Lactic acid bacteria (LAB) fermentation degrades or reorganizes polysaccharide chains, altering branching patterns and molecular weight distribution, thereby influencing their bioactivity. To elucidate the structure–activity relationship of <i>Dendrobium officinale</i> polysaccharides (DOP), the native polysaccharide was degraded by <i>Lactiplantibacillus plantarum</i> (Lp) and <i>Lacticaseibacillus rhamnosus</i> (Lr) separately, yielding two low-molecular-weight fractions (marked as Lp<i>-</i>DOP and Lr<i>-</i>DOP). These two fractions exhibited similar primary functional groups and Monosaccharide composition compared to the unfermented DOP. Methylation analysis indicated that <i>Lactobacillus</i> selectively cleaved the backbone →4-Man<i>p</i>-(1→ and branched →4,6-Man<i>p</i>-(1→ linkages, resulting in a marked increase in terminal mannose residues and a reduction in molecular weight. At optimal concentrations, all polysaccharide fractions significantly suppressed pro-inflammatory cytokine release, alleviate oxidative stress, and upregulate the gene expression of tight junction (TJ) proteins. Lp-DOP was most effective in enhancing SOD activity and the expression of <i>ZO-1</i> and <i>Occludin</i>, whereas Lr-DOP showed superior activity in suppressing pro-inflammatory cytokines and MDA levels and upregulating <i>Claudin-1</i> expression. Taken together, the structural changes caused by LAB fermentation enhanced the anti-inflammatory activity of polysaccharides. These findings provide a novel strategy for the development of high-value functional foods derived from <i>Dendrobium</i>.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148462788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Weakly Supervised Deep Learning Model for Semantic Segmentation of Pest and Disease Regions in Durian Blind Spots","authors":"Ruipeng Tang,&nbsp;Loy Chee Luen,&nbsp;Jian Rui Tang,&nbsp;Narendra Kumar Aridas,&nbsp;Mohamad Sofian Abu Talip","doi":"10.1002/efd2.70185","DOIUrl":"https://doi.org/10.1002/efd2.70185","url":null,"abstract":"<p>To address severe canopy occlusion, complex backgrounds, irregular pest-damage morphology, and the high cost of pixel-level annotation in durian orchards, this study proposes Dp-GradCAM, a weakly supervised semantic segmentation method for durian pest and disease damage areas. The method targets typical durian pests and diseases, including leaf blight, leaf spot, algal spot, leaf miner, thrips, and mealybugs, aiming to achieve accurate localization and segmentation using only image-level labels. Unlike conventional weakly supervised methods that directly rely on coarse activation maps, Dp-GradCAM first uses a ResNet50 classification network to extract discriminative features from healthy and damaged durian images and then applies Grad-CAM to generate target-category heatmaps as initial seed regions. To refine these coarse seeds, ExG filtering is used to remove interference from healthy green leaves and weeds, while DenseCRF optimizes lesion boundaries based on pixel spatial relationships and color similarity. Hole filling and morphological opening are further applied to complete target regions and remove isolated noise, generating high-quality pseudo-labels closer to real pest-damaged areas. Based on these pseudo-labels, a lightweight DeepLabv3+ segmentation network is constructed by improving the ResNet50 backbone and introducing depthwise separable dilated convolutions, reducing model complexity while preserving multi-scale semantic representation.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile Fabrication of PVA Nanofibers Decorated With Ratiometric Fluorescent Carbon Dots for Chlorpyrifos Recognition With Deep Learning","authors":"Weirui Fang,&nbsp;Xiaoyi Zhu,&nbsp;Xingyu Rong,&nbsp;Zhen Wang,&nbsp;Manjun Du,&nbsp;Shiyu Liu,&nbsp;KangJu Lee,&nbsp;Yaowen Liu","doi":"10.1002/efd2.70178","DOIUrl":"https://doi.org/10.1002/efd2.70178","url":null,"abstract":"<p>A portable and intelligent sensing platform was developed for the rapid detection of chlorpyrifos (CPS). A ratiometric fluorescent nanosensor, comprising biomass-derived iron-doped carbon dots (Fe-CDs) as the probe and silver nanoclusters as the internal reference, was immobilized onto a polyvinyl alcohol (PVA) nanofiber membrane via electrospinning. The resulting sensor achieved a limit of detection (LOD) of 13.88 µmol/L for CPS and demonstrated excellent recoveries (98.52%–105.79%) in spiked cabbage samples. A deep learning model, integrated into a smartphone application, accurately quantified CPS by analyzing images of the sensor's visual response, showing a high correlation with actual concentrations (<i>R</i>² = 0.991). This integrated system provides a simple, low-cost, and reliable tool for real-time food safety monitoring, successfully translating visual color changes into precise quantitative data.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Northeast China Traditional Kimchi (Paocai) Probiotic Resources Metabolized Uric Acid and Relieved Hyperuricemia in Mice","authors":"Aman Khan,&nbsp;Xiaoyu Wang,&nbsp;Binyu Cui,&nbsp;Xiaoqian Zhou,&nbsp;Yingying Lu,&nbsp;Lifang Ma,&nbsp;Qizhuang Li,&nbsp;Dechun Yin,&nbsp;Weidong Wang","doi":"10.1002/efd2.70187","DOIUrl":"https://doi.org/10.1002/efd2.70187","url":null,"abstract":"<p>Current pharmacological therapies for hyperuricemia (HUA), though effective, pose safety concerns, including allopurinol-induced severe dermal adverse reactions and febuxostat-related cardiovascular risks, renal, and gastrointestinal intolerance with uricosuric agents. In this study, <i>Lacticaseibacillus paracasei</i> NEFU-3 and NEFU-4 from traditional Northeast Chinese kimchi “paocai” degraded 30.22% and 24.26% of uric acid (UA), respectively, with a higher degradation of 41.93% observed in probiotic consortia (PC), thereby directly limiting the drug toxicity and organ stress associated with current therapies. Functional genomic analysis revealed that PC was enriched in urate oxidase (EC 1.7.3.3), glyoxylate reductase (EC 1.1.1.26), 5‑hydroxyisourate hydrolase (EC 3.5.2.17) and allantoinase (EC 3.5.2.5), which promote UA degradation. Mice treated with PC showed a significant 32.57% reduction in serum UA while relieving creatinine (CRE), blood urea nitrogen (BUN), and interleukin-1β (IL-1β) in HUA + PC compared with the hyperuricemic group (HUA). Moreover, PC reduced oxidative stress and improved kidney and liver health in HUA mice, enhanced the abundance of <i>Lactobacillus, Akkermansia</i>, and <i>Bifidobacterium</i> in the gut, and modulated the short-chain fatty acid profile. This study shows that kimchi (paocai)-derived probiotics can alleviate HUA by modulating UA metabolism and gut microbiota, highlighting their potential as a dietary aid for HUA.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colon-Targeted Berberine Nanoparticles-Embedded Yeast Microcapsules for Regulation of Gut Immunity of Sepsis","authors":"Qing-Qing Dong,&nbsp;Si-Hui Wang,&nbsp;Chen-Yan Wang,&nbsp;Ke-Da Yang,&nbsp;Xiao-Ling Xu,&nbsp;Yi Shi,&nbsp;Wei Chen","doi":"10.1002/efd2.70184","DOIUrl":"https://doi.org/10.1002/efd2.70184","url":null,"abstract":"<p>Sepsis often progresses to multiorgan failure through intestinal barrier disruption and bacterial translocation. Berberine (BBR) has anti-inflammatory and intestinal protective activity, but its oral use is limited by poor solubility and low bioavailability (&lt; 1%). Here, we designed BGNP@YM, an oral colon-targeted system in which BBR-loaded gelatin nanoparticles (BGNP) are encapsulated within yeast microcapsules (YM), and tested it in a lipopolysaccharide (LPS)-induced sepsis mouse model. BGNP@YM was stable in simulated gastric and intestinal fluids and released its payload in simulated colonic fluid, confirming colon-specific delivery. In vivo, BGNP@YM outperformed free BBR, BGNP, or YM alone, improving survival, attenuating weight loss and splenomegaly, and lowering TNF-α, IL-6, and IL-1β in colonic and renal tissues. Histology showed restored intestinal barrier integrity and reduced injury in multiple organs, with no detectable hepatic or renal toxicity. 16S rRNA sequencing further revealed partial reversal of sepsis-induced dysbiosis, with increased microbial diversity, a restored <i>Firmicutes</i>/<i>Bacteroidetes</i> ratio, and enrichment of short-chain fatty acid (SCFA)-producing taxa such as <i>Odoribacter</i>. The associated renal protection is consistent with a gut-kidney axis effect. These findings support BGNP@YM as a promising oral candidate for the treatment of sepsis-induced intestinal injury.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}