eFood最新文献

{"title":"Exploring the multifaceted therapeutic potentials of Brassaiopsis palmata (leaves) through in-vitro and in-vivo approaches","authors":"Mohidul Islam,&nbsp;Fowzul Islam Fahad,&nbsp;Ahasanul Karim,&nbsp;Arifa Sultana,&nbsp;A. T. M. Mostafa Kamal,&nbsp;Md. Sohel Rana,&nbsp;Mohammad Nazmul Islam","doi":"10.1002/efd2.70009","DOIUrl":"https://doi.org/10.1002/efd2.70009","url":null,"abstract":"<p><i>Brassaiopsis palmata</i>, an androgynous tree from Araliaceae family, has been widely found in the Asian subcontinent, and reported to have potentiality against skin infection, and many therapeutic properties still unidentified. Here, our current investigation aims to discover the innovative pharmacological potentials of the methanol extract of <i>B. palmata</i> leaves (MEBPL) through in-vivo and in-vitro approaches. Several secondary metabolites were revealed throughout the qualitative phytochemical screening of the plant extracts. MEBPL exhibited strong radical scavenging properties (IC₅₀ 178.13 µg/mL) through the 2, 2-diphenyl-1-picryhydrazyl (DPPH) assay, and through the quantitative (phenolic and flavonoid) assays with a moderate (LD₅₀ 153.14 µg/mL) toxic effect. In anti-inflammatory screening, MEBPL showed significant dose dependent inhibitory activity; and the peak inhibition were found 78.01 ± 1.22% and 82.46 ± 1.52% at 1000 µg/mL concentration on hypotonic-induce RBC hemolysis &amp; protein denaturation test respectively. Moreover, the plant extracts manifested moderate percentage of clot lysis (28.24 ± 2.50%) on the investigation of thrombolytic assay. The anti-nociceptive activity of MEBPL was analyzed through acetic acid and formalin induce pain tests. Both 200 and 400 mg/kg dose of MEBPL exerted significant (<i>p </i>˂ 0.001) dose depending depletion of acetic acid induced writhing and formalin stimulated licking test which indicated strong analgesic properties of plant extracts. In addition, the outcomes of anti-depressant evaluation suggested that treatment with both 200 and 400 mg/kg doses showed potential dose depending activity on both FST and TST model. Furthermore, the plant extracts manifested dose dependent reduction of anxiety like behaviors in the rodent model. Particularly, mice administrated with 400 mg/kg dose of MEBPL significantly (<i>p</i> ˂ 0.05) enhanced the percentage of entries and time spent in the open arm in EPM, and also showed the highest amount of head dipping tendency in HBT. In contrast, the outcomes of this research suggest that <i>B. palmata</i> could be another source of antioxidant, cytotoxic, anti-inflammatory, thrombolytic, anti-nociceptive, anti-depressant, and anxiolytic agents. Further research on the mechanisms underlying bioactivities is required.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel arabinogalactan extracted from Epiphyllum oxypetalum (DC.) Haw improves the immunity and gut microbiota in cyclophosphamide-induced immunosuppressed mice","authors":"Jin Dai,&nbsp;Zhiwei Zhou,&nbsp;Liangwei Chen,&nbsp;Shujuan Cao,&nbsp;Ke Luo,&nbsp;Jinmei Zhang,&nbsp;András Dinnyés,&nbsp;Dan Wang,&nbsp;Qun Sun","doi":"10.1002/efd2.70002","DOIUrl":"https://doi.org/10.1002/efd2.70002","url":null,"abstract":"<p>A novel type I arabinogalactan (AG-I) polysaccharide (EPS) from <i>Epiphyllum oxypetalum (DC.) Haw</i>'s flowers is hypothesized to possess immunomodulatory activity. This study investigated EPS's effects on immune functions and its potential mechanism for enhancing intestinal health in immunosuppressed mice. The results showed that supplementing EPS significantly alleviated immune organ damage, increased the thymus index (<i>p</i> &lt; 0.01), and regulated the key immune factors, including the tumor necrosis factor-alpha (TNF-α), immunoglobulin A (IgA), and complement 3 (C3) in the liver (<i>p</i> &lt; 0.05). EPS promoted the expression of intestinal immune barrier and chemical barrier proteins such as interferon-γ (IFN-γ) and mucin 2 (MUC2) (<i>p</i> &lt; 0.05), effectively repairing intestinal damage. EPS improved the diversity and structure of intestinal microbiota in immunosuppressed mice (<i>p</i> &lt; 0.05) and significantly altered the abundance of intestinal immune-related microbial taxa, including <i>Lactobacillaceae</i> and <i>Lactobacillus</i> (<i>p</i> &lt; 0.01). Furthermore, EPS supplementation altered intestinal lactic acid metabolism, significantly increasing lactic acid levels by up to 3.4-fold (<i>p</i> &lt; 0.01), and enhanced the expression of Gpr81, Wnt3a, and β-catenin proteins at the bottom of the colonic crypts, which may repair the intestinal physical barrier. Overall, EPS represents a novel AG-I immunomodulatory dietary polysaccharide that enhances immunity and improves gut health.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of live transport methods on the survivability, physiological responses, and flesh quality of turbot (Scophthalmus maximus)","authors":"Chune Liu,&nbsp;Aiqi Lin,&nbsp;Zixuan Li,&nbsp;Zheng Ma,&nbsp;Feng Liu","doi":"10.1002/efd2.70011","DOIUrl":"https://doi.org/10.1002/efd2.70011","url":null,"abstract":"<p>Waterless transport is an alternative method for live aquatic products. However, the changes that occur in the fish body after transportation are not known. Herein, the effects of different transport methods on quality of turbot (<i>Scophthalmus maximus</i>) were investigated. Fish were divided into four groups: Group A (water, 17°C), Group B (waterless, 3°C), Group C (water, 3°C), and Group D (control, 17°C). In the case of 100% survival, the maximum transport time was 40 h for Group A, 55 h for Group B, and 90 h for Group C. Both crude protein and crude fat decreased significantly (<i>p</i> &lt; 0.05) in the treatment groups compared with the control group. Compared with control group, lactic dehydrogenase (LDH), lactic acid (LA), and serum cortisol (COR) increased significantly (<i>p</i> &lt; 0.05) in all treatment groups. After fish recovered, LDH, LA, and COR values were all significantly (<i>p</i> &lt; 0.05) lower than their corresponding non-recovered group. Compared with the control group, the expression of proteins related to muscle motility and stress capacity both decreased in the low-temperature, waterless group. Together, obvious damage may occur to flesh quality, liver, and heart of turbot when the transport time is &gt;40 h, regardless of the transport method.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on daidzein as food supplement: Exploring its phytopharmacological and preclinical status","authors":"Sana Ahmad,&nbsp;Farogh Ahsan,&nbsp;Javed Akhtar Ansari,&nbsp;Tarique Mahmood,&nbsp;Arshiya Shamim,&nbsp;Shahzadi Bano,&nbsp;Reshu Tiwari,&nbsp;Vaseem Ahamad Ansari,&nbsp; Shafiurrahman,&nbsp;Mithilesh Kesari","doi":"10.1002/efd2.70008","DOIUrl":"https://doi.org/10.1002/efd2.70008","url":null,"abstract":"<p>A natural product is a compound or substance originating from a living organism and found in nature. Daidzein belongs to the class of bioflavonoids, which are plant-derived compounds with various biological activities. Predominantly exists in soybeans and several legumes in either glycoside or aglycone forms. Its primary chemical constituents include metabolites like equol and trihydroxy isoflavone, generated through the influence of intestinal bacteria. Daidzein has exhibited pharmacological impacts on different ailments, including cardiovascular disease, cancer, diabetes, skin disorders, osteoporosis, and neurodegenerative disorders. Daidzein's mechanisms of action involve interactions with estrogen receptors, as well as its antioxidant and anti-inflammatory properties, along with its ability to regulate apoptosis and the cell cycle. In efforts to enhance its solubility, stability, bioavailability, and targeting, daidzein has been innovatively formulated into novel dosage forms, including nanoparticles, liposomes, microemulsions, and nanosuspensions. As a promising nutraceutical, daidzein presents multiple health benefits and holds potential for various clinical applications. Additional investigation is required to comprehend the molecular mechanisms of this phenomenon and assess its safety. The purpose of this review is to provide a short description of the therapeutic properties, chemical composition, traditional use, toxicology profile, new insights on the dosage form, and future prospects of daidzein.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of fat-free mulberry ice cream by using inulin and whey protein isolate as a fat substitute","authors":"Anantita Sangsuriyawong,&nbsp;Pathompol Suwanmongkol,&nbsp;Napassorn Peasura,&nbsp;Nichapha Kornsakkaya,&nbsp;Sasapin Disnil,&nbsp;Pornrat Sinchaipanit,&nbsp;Nilesh Nirmal","doi":"10.1002/efd2.70006","DOIUrl":"https://doi.org/10.1002/efd2.70006","url":null,"abstract":"<p>The standard ice cream consists of high calories and fat which could cause metabolic syndrome upon regular consumption. Therefore, this study developed a fat-free ice cream using fat replacer including inulin (carbohydrate-based) and whey protein isolate (WPI, protein-based) at various concentrations (6%, 8%, and 10%) or their combination (1:1). Additionally, freeze-dried mulberry fruit powder was used as a functional ingredient. The results indicated that both, inulin and WPI, function differently thereby affecting the physicochemical properties of the ice cream. The combination of inulin:WPI at a 4:4 ratio produced high-quality standard ice cream with a higher sensory score. Further incorporation of freeze-dried mulberry powder (2%) in a selected fat-free ice-cream base showed enhanced sensory, nutraceutical, and textural properties of the ice cream. All fat-free and fat-free mulberry ice cream had a trace amount of fat (0.06%), while the calorie was reduced to 88.9 kcal/serving compared with a full-fat ice cream (195.7 kcal/serving). Hence, fat-free mulberry ice cream with 74.5% of nonfat milk, 5.0% of skim milk powder, 8% of inulin:WPI (4:4), 9.5% of sugar, 0.5% of emulsifier, and 2% freeze-dried mulberry powder could serve as the best alternative to the full-fat ice cream.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward improved human health: Ferroptosis-related “Hyperfoods” as the nutritional supplement in COVID-19","authors":"Yanan Zhao,&nbsp;Hui Cao,&nbsp;Linyin Ma,&nbsp;Zixu Wang,&nbsp;Shuang Guan,&nbsp;Hui Teng,&nbsp;Lei Chen","doi":"10.1002/efd2.183","DOIUrl":"https://doi.org/10.1002/efd2.183","url":null,"abstract":"<p>The outbreak of coronavirus disease 2019 (COVID-19) stimulates a body of studies for better investigating the essential mechanisms and clinical characteristics of this disease. Notwithstanding, the underlying mechanisms of multiple organ failure (MOF) remain unclear. Understanding the mechanism of COVID-19-stimulated programmed cell death (RCD) may contribute to better strategies for these patients. Based on the exploration of COVID-19-related basic science reports and clinical research, we speculate that ferroptosis, a recently identified RCD, might be a substantial stimulator for MOF in COVID-19, and it may act as a novel treatment target. However, the published investigations to determine how ferroptosis works in severe acute respiratory syndrome coronavirus 2 infection are still lacking. This review reveals new crucial missing links in our prevailing understanding of the mechanisms that ferroptosis-triggered MOF in COVID-19 patients. We also specifically summarize several literatures evidence about the functional food components as the nutritional supplement for COVID-19 by its characteristics of ferroptosis inhibition. We hope this hypothesis may launch a new wave of studies to unveil the relationship between ferroptosis and COVID-19 and explore more ferroptosis-related functional food components in daily life for preventing the COVID-19 and/or to improve the outcome during therapy.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black raspberry extract stimulates glucose uptake via adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways in skeletal muscle cells","authors":"Hui-Fang Chiu,&nbsp;Oksana Golovinskaia,&nbsp;Yohanes Tandoro,&nbsp;Li-Shu Wang,&nbsp;Chin-Kun Wang","doi":"10.1002/efd2.176","DOIUrl":"https://doi.org/10.1002/efd2.176","url":null,"abstract":"<p>Black raspberry (<i>Rubus occidentalis</i>) shows beneficial health effects, such as antioxidant, anti-inflammatory, chemopreventive, antiproliferative, and antihyperglycemic activities. The present study investigated the antihyperglycemic activity of black raspberry extract (BRE) and potential mechanisms in skeletal muscle cells. Differentiated C2C12 myotubes were treated with the BRE (1–1000 μg/mL) or metformin (1 mM). The protein levels of various insulin signaling targets were measured by western blot analysis. BRE significantly increased glucose uptake by upregulated insulin receptor and phosphatidylinositol-3 kinase (PI3K) in C2C12 cells, leading to enhanced translocation of glucose transporter 4 (GLUT4) to the plasma membrane. The expression of phosphorylated (p)-adenosine monophosphate-activated protein kinase (AMPK) was also enhanced by treatment with BRE, this resulting in stimulation of GLUT4 translocation to the plasma membrane and hence glucose uptake in skeletal muscles. These results suggest that BRE has an antihyperglycemic effect by stimulating GLUT4 translocation to the plasma membrane via activating the PI3K and AMPK pathways in skeletal muscle cells, thereby upregulating glucose uptake. Black raspberry is a potential functional food and has important implications for preventing and treating type-2 diabetes. In addition, our study found that the flavonoids fraction is the main contributor fraction to promote glucose uptake in C2C12 cells.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricholoma matsutake heptapeptide prevents gastric mucosa injury by regulating oxidative stress-related mitochondrial function and mucous layer integrity","authors":"Renzhi Lv,&nbsp;Zhiqiang Lu,&nbsp;Zhihong Zheng,&nbsp;Zhijie Bao,&nbsp;Songyi Lin","doi":"10.1002/efd2.70004","DOIUrl":"https://doi.org/10.1002/efd2.70004","url":null,"abstract":"<p>Short-term excessive alcohol consumption easily leads to ethanolic gastric injury. Recent research on bioactive functional factors in preventing and treating ethanol-induced acute gastric injury has garnered attention. This study explored the direct protective effects of the <i>Tricholoma matsutake</i>-derived peptide Ser–Ala–Pro–Trp–Gly–Leu–Ala (SAPWGLA) on ethanol-induced acute gastric damage. The results showed that SAPWGLA showed dose-dependent protection against gastric mucosal injury, including the regulation of oxidative stress and mitochondrial function, as well as the enhancement of mucosal barrier integrity. SAPWGLA maintained normal mitochondrial metabolism by alleviating intracellular reactive oxygen species (ROS) accumulation; 400 mg/mL SAPWGLA reduced ROS levels by 81.72 ± 1.55% and reversed the decrease of MMP by ethanol to 1.22 ± 0.01 (J-aggregates/monomer) in GES-1 cells. Also, SAPWGLA enhanced the tight junctions between GES-1 cells. In addition, SAPWGLA improved the integrity of the mucosal barrier by maintaining the balance of the mucus layer and regulating the expression of TJ proteins. Daily oral administration of SAPWGLA (50 mg/kg) exhibited a restoration in hexosamine to 10.76 ± 0.73 mg/g prot, a regulation in claudin-1, occludin, and ZO-1 (1.21-, 1.39-, and 0.73-fold of the control group). These findings suggest that SAPWGLA can be a potential novel therapeutic approach to dealing with acute gastric injury caused by ethanol.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antihyperuricemic and nephroprotective effect of puerarin by reducing uric acid level and exerting anti-inflammatory activity","authors":"Muxuan Wang,&nbsp;Yong Zhao,&nbsp;Nan Chen,&nbsp;Yanao Wang,&nbsp;Xu Guo,&nbsp;Ningyang Li,&nbsp;Haoran Liu,&nbsp;Hui Sun,&nbsp;Chao Liu,&nbsp;Zhixin Liao","doi":"10.1002/efd2.70005","DOIUrl":"https://doi.org/10.1002/efd2.70005","url":null,"abstract":"<p>Hyperuricemia (HUA) is a common metabolic disease and kidney injury is one of its main complications. As a typical natural flavonoid, puerarin (PEA) has a range of pharmacological activity but the antihyperuricemic mechanism of PEA has not been reported. Herein, the inhibitory activity of PEA against xanthine oxidase (XOD) was evaluated by in vitro enzymatic reaction, and kinetic analysis, the antihyperuricemic activity, and nephroprotective effect of PEA were studied in HUA mice. The enzymatic reaction showed that the inhibitory effect of PEA (half maximal inhibitory concentration [IC₅₀] = 4.39 µmol/L) on XOD was at the same level as allopurinol (IC₅₀ = 4.05 µmol/L), and kinetic analysis indicated that PEA was a mixed competitive inhibitor. In vivo studies demonstrated that PEA exhibited excellent antihyperuricemic activity by inhibiting XOD and urate transporter 1 (URAT1), to reduce uric acid level. At the same time, PEA reduced the level of inflammatory cytokines and exerted significant nephroprotective effect through anti-inflammatory activity. Molecular docking indicated that PEA closely bind to both XOD and URAT1, which had the potential to become an inhibitor of XOD and URAT1. In summary, PEA has important application value in developing novel functional food and medicine for the treatment of HUA and its complications.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling connections with artificial sweeteners and their impact on human health: A comprehensive review","authors":"Niranjana Karukayil Gopalakrishnan,&nbsp;Balamuralikrishnan Balasubramanian,&nbsp;Rohan Kundapur,&nbsp;Aditi Chaudhary,&nbsp;Arun Meyyazhagnan,&nbsp;Manikantan Pappuswamy","doi":"10.1002/efd2.184","DOIUrl":"https://doi.org/10.1002/efd2.184","url":null,"abstract":"<p>There is a recent trend showing an uptick in the artificial sweetener's usage, particularly the nonnourishing variety. The allure of a low-calorie choice that lets people indulge in their sweet tooths while consuming less calories overall is what motivates this. Children's food products often contain a substantial number of artificial sweeteners due to their properties that aid in moisture retention, act as fillers, and serve as bulking agents. This article provides a comprehensive overview of artificial sweeteners and influences in human wealth. Studies have linked the use of artificial sweeteners to premature birth, highlighting the teratogenic potential of these compounds, particularly in beverages. Pregnant women who incorporate nonnutritive sweeteners into their diet during pregnancy are more likely to have children with birth defects, as indicated by studies on the subject. Artificial sweeteners should not be added to food for children because studies show that eating them while a child's body is still developing might disturb the balance of gut microbiota and cause potential problems like heart disease, stroke, and cognitive decline. The ingestion of nonnourishing sweeteners has adverse effects on the fertility of both men and women. Studies indicate that exceeding the recommended daily consumption that the FDA has set for artificial sweeteners can result in conditions of infertility for both genders. Additionally, there is a connection between the onset of cancer and the use of artificial sweeteners. Presently, a considerable amount of research relies on animal models rather than human ones, creating a notable gap in research. The limitation of extensive human model studies represents a drawback in validating results. Furthermore, there is a necessity for increased research focused on advancing techniques that can minimize the adverse effects of artificial sweeteners, making them more suitable for addressing issues related to obesity and various types of diabetes.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"5 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}