IF 5.7

eFood Pub Date : 2026-06-29 DOI: 10.1002/efd2.70188

Qiaowen Deng, Yuehan Wang, Feiyang Zheng, Manqin Fu, Chumin Zhong, Dharmani Devi Murugan, Wai San Cheang

{"title":"3,3′,4,5′-Tetramethoxy-trans-stilbene Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease","authors":"Qiaowen Deng, Yuehan Wang, Feiyang Zheng, Manqin Fu, Chumin Zhong, Dharmani Devi Murugan, Wai San Cheang","doi":"10.1002/efd2.70188","DOIUrl":"https://doi.org/10.1002/efd2.70188","url":null,"abstract":"Prolonged high-fat diet causes insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD). 3,3′,4,5′-Tetramethoxy-trans-stilbene (3,3′,4,5′-TMS), a methoxy derivative of resveratrol, has been demonstrated to ameliorate oxidative stress and insulin resistance in vitro. However, it remains unclear whether 3,3′,4,5′-TMS exhibits protective effects on insulin resistance-related MASLD, which is investigated in the current study. Male C56BL/6 J mice were fed a high-fat diet (60 kcal% fat) for 12 weeks to establish a model of diet-induced obesity (DIO) with insulin resistance and associated MASLD. 3,3′,4,5′-TMS (10 mg/kg/d) was intragastrically administered for 4 weeks. Hematoxylin and eosin, Oil-red O, and periodic acid-Schiff staining were performed to observe pathological changes of the liver. Protein markers for antioxidant and insulin signaling pathways were assessed by Western blot. 3,3′,4,5′-TMS treatment ameliorated hyperglycemia, hyperlipidemia, and fatty liver in insulin-resistant and MASLD mice. 3,3′,4,5′-TMS regulated blood glucose through the activation of the insulin signaling pathway: increasing phosphorylation of IRS1 (Ser307), Akt (Ser473), and GSK3β (Ser9), upregulating protein expression of IRS2 and PI3K, and decreasing phosphorylation of GS (Ser641) in DIO mouse liver. Furthermore, 3,3′,4,5′-TMS reduced oxidative stress in livers by upregulating Nrf2/HO-1 signaling pathway. These findings indicate that 3,3′,4,5′-TMS ameliorates insulin resistance and MASLD, possibly through the activation of IRS/PI3K/Akt/GSK3β/GS and Nrf2/HO-1 pathways.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Metabolomic and Transcriptomic Analysis Revealed the Capsanthin Biosynthesis and Sequestration in Processing Type Red Pepper (Capsicum annuum var. conoides) 综合代谢组学和转录组学分析揭示加工型红辣椒辣椒素的生物合成和封存

IF 5.7

eFood Pub Date : 2026-06-28 DOI: 10.1002/efd2.70183

Qi Chen, Ming Wang, Minjie Duan, Youjin Hao, Jian Ming, Honghai Li

{"title":"Integrated Metabolomic and Transcriptomic Analysis Revealed the Capsanthin Biosynthesis and Sequestration in Processing Type Red Pepper (Capsicum annuum var. conoides)","authors":"Qi Chen, Ming Wang, Minjie Duan, Youjin Hao, Jian Ming, Honghai Li","doi":"10.1002/efd2.70183","DOIUrl":"https://doi.org/10.1002/efd2.70183","url":null,"abstract":"Fruit color in red peppers is a key determinant of processing adaptability, yet its metabolic and genetic mechanisms in typical Yanjiao cultivars remain poorly understood. Here, we integrated chromatic phenotyping, targeted carotenoid metabolomics, and comparative transcriptomics across 10 Yanjiao cultivars. Colorimetric analysis identified three phenotypic groups, with the yellow-blue indices showing the greatest variation. Metabolomics classified cultivars into four metabolic types: high-efficiency capsanthin synthesizer with coordinated precursor flux and extensive esterification; precursor-accumulating genotypes with bottlenecks in red pigment formation; esterification-specialized cultivars stabilizing pigments through laurate/myristate esterification; and synthesis-inhibited cultivars accumulating atypical metabolites. Multivariate analyses linked redness mainly to capsanthin and zeaxanthin, whereas yellowness was associated with zeaxanthin ester pools. Comparative transcriptomes of representative cultivars (Yj425, Yj485, Yj518, and Yj666) identified 34 carotenoid metabolism-related differentially expressed genes. High‑pigment cultivars exhibited coordinated upregulation of PSY paralogs and GGPPS, while branch-specific regulation involved CYP97C expression gradients. Fruit color variation in Yanjiao peppers arose from two synergistic mechanisms: capsanthin biosynthesis efficiency and acyl‑transferase‑mediated sequestration stabilizing chromophores. These findings provide mechanistic targets for marker‑assisted breeding, metabolic engineering, and postharvest improvement of color stability and nutraceutical value in red pepper.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moutan Cortex Extract Mediates Diabetic Retinopathy by Blocking the ROS‑Triggered HIF-1α/VEGF Axis in Retinal Pigment Epithelial Cells 牡丹皮提取物通过阻断视网膜色素上皮细胞中ROS触发的HIF-1α/VEGF轴介导糖尿病视网膜病变

IF 5.7

eFood Pub Date : 2026-06-28 DOI: 10.1002/efd2.70179

Mei-rong Li, Xian-yi Zhang, Wan-ying Zhang, Nan Chen, Wei-wei Lv, Tian-yu Liu, Xu Guo, Ying-ying Chen, Meng-qi Zhang, Shu-tao Sun, Mu-xuan Wang, Qi-dong Ren, Chao Liu, Jin-yue Sun

{"title":"Moutan Cortex Extract Mediates Diabetic Retinopathy by Blocking the ROS‑Triggered HIF-1α/VEGF Axis in Retinal Pigment Epithelial Cells","authors":"Mei-rong Li, Xian-yi Zhang, Wan-ying Zhang, Nan Chen, Wei-wei Lv, Tian-yu Liu, Xu Guo, Ying-ying Chen, Meng-qi Zhang, Shu-tao Sun, Mu-xuan Wang, Qi-dong Ren, Chao Liu, Jin-yue Sun","doi":"10.1002/efd2.70179","DOIUrl":"https://doi.org/10.1002/efd2.70179","url":null,"abstract":"Moutan Cortex is a functional food ingredient with multiple health benefits, but its effects on diabetic retinopathy (DR) remain unexplored. This study elucidates the protective roles and mechanistic insights of Moutan Cortex extract (MCE, 50% ethanol) against DR using streptozotocin-induced diabetic rats and human retinal pigment epithelial (ARPE-19) cells challenged with high glucose. Daily gavage of 100, 200, and 400 mg/kg MCE over 8 week dose-dependently preserved retinal structure in diabetic rats (all p < 0.05). Network pharmacology predicted the hypoxia-inducible factor 1-alpha/vascular endothelial growth factor (HIF-1α/VEGF) axis as a critical pathway. Accordingly, MCE reduced HIF-1α and VEGF protein levels in both rat retina and ARPE-19 cells under hyperglycemia. In wound healing assays using conditioned medium from MCE-treated ARPE-19 cells (100, 200, and 400 μg/mL), endothelial cell migration at 24 h was reduced to 45.4%, 37.0%, and 26.4%, respectively, indicating a paracrine anti-angiogenic effect. MCE also significantly alleviated reactive oxygen species (ROS) overproduction. Notably, H2O2 or the HIF-1α agonist CoCl2 both reversed the inhibitory effect of MCE (400 μg/mL) on high-glucose-mediated HIF-1α and VEGF overexpression. These findings indicate that MCE alleviates DR progression, partly by paracrine-mediated anti-angiogenesis, suppressing the HIF-1α/VEGF axis through ROS reduction in retinal pigment epithelium (RPE) cells.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stage-Specific Metabolic and Proteomic Dynamics Underlying Ripening and Quality Formation in Tropical Evergreen Pomegranate 热带常绿石榴成熟和品质形成的阶段特异性代谢和蛋白质组动力学

IF 5.7

eFood Pub Date : 2026-06-25 DOI: 10.1002/efd2.70180

Yawen Zhang, Ling Wei, Kaibing Zhou, Qin Deng, Muhammad Mobeen Tahir, Hongxia Wu, Minjie Qian

{"title":"Stage-Specific Metabolic and Proteomic Dynamics Underlying Ripening and Quality Formation in Tropical Evergreen Pomegranate","authors":"Yawen Zhang, Ling Wei, Kaibing Zhou, Qin Deng, Muhammad Mobeen Tahir, Hongxia Wu, Minjie Qian","doi":"10.1002/efd2.70180","DOIUrl":"https://doi.org/10.1002/efd2.70180","url":null,"abstract":"Pomegranate fruit development involves coordinated physiological, metabolic, and proteomic changes shaping coloration and quality. Fruit expansion and peel/aril pigmentation were most active between 90 and 130 days, when soluble solids increased and organic acids fluctuated, producing the highest sugar-acid ratio. Widely targeted metabolomics detected 1,815 metabolites, including 945 differentially accumulated metabolites (DAMs; 90d_vs_15d) and 170 DAMs (130d_vs_90d), mainly phenolic acids, flavonoids, terpenoids, and alkaloids. Early DAMs were enriched in nucleotide and phenylalanine metabolism, whereas late DAMs were linked to anthocyanin biosynthesis and hormone signaling. Cyanidin- and pelargonidin-derived flavonoids paralleled fruit coloration. Proteomics quantified 9,585 proteins, identifying 4,031 early and 329 late differentially abundant proteins (DAPs), with dynamic regulation of phenylpropanoid, flavonoid, carbohydrate metabolism, glycolysis, gluconeogenesis, and TCA pathways. WGCNA revealed stage-specific modules associated with phenylpropanoid biosynthesis, carbohydrate metabolism, and amino acid pathways. These integrated results provide a temporal multi-omics framework linking metabolite accumulation, sugar-acid ratio, and pathway regulation to pomegranate ripening and quality formation, highlighting how stage-specific metabolic and proteomic shifts underpin the development of color, flavor, and overall fruit quality during fruit maturation.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wild Edible Plants in Angola: Diversity, Traditional Uses, Phytochemical Properties, and Socio-Economic Potential 安哥拉野生食用植物：多样性、传统用途、植物化学特性和社会经济潜力

IF 5.7

eFood Pub Date : 2026-06-25 DOI: 10.1002/efd2.70177

Claudete Bastos, Ângela Liberal, Margarida Moldão, Lillian Barros, Luís Catarino

{"title":"Wild Edible Plants in Angola: Diversity, Traditional Uses, Phytochemical Properties, and Socio-Economic Potential","authors":"Claudete Bastos, Ângela Liberal, Margarida Moldão, Lillian Barros, Luís Catarino","doi":"10.1002/efd2.70177","DOIUrl":"https://doi.org/10.1002/efd2.70177","url":null,"abstract":"With almost 7000 native species, Angola is one of the African countries with the most remarkable plant diversity. Rural communities use many wild plants daily to fulfill various needs, particularly as food. This study aimed to explore the diversity and uses of wild edible plants (WEP) in Angola, through a literature review, consultation of herbarium collections, and fieldwork by the first author. Through an analysis of databases, books, and scientific articles, and consulting herbarium records, it was possible to identify 199 WEP used in Angola. The main types of plants with edible parts were trees, annual and perennial herbs, shrubs and sub-shrubs, and, to a lesser extent, lianas and herbaceous vines, which are found in forests, woodlands, riverbanks, and gallery forests, as well as in fallows and disturbed places. The most consumed parts of plants are fruits, seeds, leaves, and, to a lesser extent, the underground parts. Many of these plants have great economic value, serving as both food sources and additional income for rural families. The identification and characterization of WEP has enabled a deeper understanding of the country's plant genetic resources, which can help improve food security and promote the sustainable use of natural resources in Angola.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro- and Nanostructured Materials in Edible Coatings for the Preservation of Fruits and Vegetables 微纳米结构材料在果蔬保鲜膜中的应用

IF 5.7

eFood Pub Date : 2026-06-24 DOI: 10.1002/efd2.70169

Carlos Méndez-Durazno, Katherine Vaca-Escobar, Fernanda Landeta-Constante, Santiago Guerrero-Jaramillo, Milton Villacís-García, Patricio J. Espinoza-Montero

{"title":"Micro- and Nanostructured Materials in Edible Coatings for the Preservation of Fruits and Vegetables","authors":"Carlos Méndez-Durazno, Katherine Vaca-Escobar, Fernanda Landeta-Constante, Santiago Guerrero-Jaramillo, Milton Villacís-García, Patricio J. Espinoza-Montero","doi":"10.1002/efd2.70169","DOIUrl":"https://doi.org/10.1002/efd2.70169","url":null,"abstract":"Edible coatings based on advanced nanostructured materials have emerged as effective strategies for extending the shelf life and maintaining the quality of fresh fruits and vegetables. This review provides a comprehensive overview of recent developments in nanocomposite coating systems, including metal and metal oxide nanoparticles, nanoclays, carbon nanodots, nanofibers, and nanofibril-based hydrogels. These materials exhibit multifunctional properties such as antimicrobial and antioxidant activity, UV shielding, enhanced mechanical strength, and controlled gas and moisture permeability. The integration of nanomaterials into biopolymer matrices enables synergistic interactions that regulate ethylene levels, suppress microbial growth, and reduce oxidative and enzymatic degradation during storage and transportation. Particular emphasis is placed on sustainable synthesis routes, bioinspired nanostructures, and sprayable or in situ-formed coatings suitable for perishable produce. Recent advances demonstrate that carbon nanodots and nanofibril hydrogels are especially promising due to their biocompatibility, tunable functionality, and superior preservation performance. Despite significant progress, challenges remain in large-scale production, regulatory approval, and comprehensive assessment of nanomaterial toxicity. Future research should focus on safety evaluation, scalability, and data-driven material design using in silico approaches. Overall, nanostructured edible coatings represent a versatile and sustainable platform for next-generation postharvest preservation technologies.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mediating Role of Digital Market and Payment Systems in ICT-Based Food Security Management 数字市场和支付系统在基于信息通信技术的粮食安全管理中的中介作用

IF 5.7

eFood Pub Date : 2026-06-22 DOI: 10.1002/efd2.70181

Mohammad Helal Hossain, Mohammad Rakibul Islam Bhuiyan, Khadija Sharmin, M. Helal Uddin Ahmed

{"title":"The Mediating Role of Digital Market and Payment Systems in ICT-Based Food Security Management","authors":"Mohammad Helal Hossain, Mohammad Rakibul Islam Bhuiyan, Khadija Sharmin, M. Helal Uddin Ahmed","doi":"10.1002/efd2.70181","DOIUrl":"https://doi.org/10.1002/efd2.70181","url":null,"abstract":"This study examines how Food Production and Distribution (FPD), Food Security (FS), and Digital Market and Payment (DMP) interact to influence Food Security Management (FSM), with a particular focus on the mediating role of DMP. These constructs are particularly relevant to Bangladesh. A quantitative research design was employed, collecting data through structured questionnaires from 400 respondents across Bangladesh. Data analysis was conducted using Partial Least Squares Structural Equation Modeling (PLS-SEM) to test the proposed relationships among the constructs and assess the model's validity and reliability. The results indicate that FPD and DMP significantly predict FSM, while FS shows limited direct influence. Notably, DMP serves as a strong mediator between FPD and FSM, highlighting the critical role of digital platforms in enhancing food system governance. This study contributes by integrating digital innovation into the food security discourse through a validated structural model for policymakers and stakeholders to strengthen ICT infrastructure and align agricultural strategies with digital transformation to support Bangladesh's progress toward SDG 2 and SDG 9.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking Palm Oil Quality Evolution During Frying to the Shelf-Life of Low-Temperature Vacuum-Fried Whole Okra Crisps 油炸过程中棕榈油品质演变与低温真空油炸秋葵脆片保质期的关系

IF 5.7

eFood Pub Date : 2026-06-18 DOI: 10.1002/efd2.70176

Mengjie Yang, Yusha Liu, Junzheng Sun, Zheng Xiao, Qiting Li, Shaoxiong Zhou, Chunmei Lai, Baosha Tang, Li Wu, Junchen Chen, Pufu Lai

{"title":"Linking Palm Oil Quality Evolution During Frying to the Shelf-Life of Low-Temperature Vacuum-Fried Whole Okra Crisps","authors":"Mengjie Yang, Yusha Liu, Junzheng Sun, Zheng Xiao, Qiting Li, Shaoxiong Zhou, Chunmei Lai, Baosha Tang, Li Wu, Junchen Chen, Pufu Lai","doi":"10.1002/efd2.70176","DOIUrl":"https://doi.org/10.1002/efd2.70176","url":null,"abstract":"The quality of frying oil is a critical determinant of the shelf life of fried foods. This study established a direct link between the progressive degradation of palm oil during repeated low-temperature vacuum frying (LTVF) of whole okra and the subsequent quality evolution of the final whole okra crisps during a 180-day storage period. Key chemical indices and innovative Low-Field Nuclear Magnetic Resonance (LF-NMR) were employed to track oil deterioration over six frying cycles. Results demonstrated a significant increase in hydrolytic and oxidative products (acid value, peroxide value, carbonyl value, p-anisidine value) and process contaminants (GEs, 3-MCPDEs) in the oil with each cycle. During storage, the resultant whole okra crisps showed a corresponding decline in quality, marked by increased moisture content, lipid oxidation, and significant color degradation (total color difference, ΔE, reached 3.12). Crucially, this work demonstrates that the number of frying cycles is a key control point for ensuring both the initial quality and long-term stability of LTVF products. Our findings provide a scientific basis for process optimization, confirming a shelf life of at least 180 days is achievable for whole okra crisps produced under controlled LTVF conditions.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cordyceps militaris Ethanol Extract Alleviates Hyperglycemia in Type 2 Diabetic Mice in Association With Gut Microbiota Modification 蛹虫草乙醇提取物通过改变肠道菌群减轻2型糖尿病小鼠的高血糖

IF 5.7

eFood Pub Date : 2026-06-18 DOI: 10.1002/efd2.70175

Huanhuan Wen, Wenke Hu, Xinru Xu, Na Wu, Huangcong Ding, Haonan Wang, Xiaoyu Gao, Ligen Chen, Chao Zhao, Rong Shao, Wei Xu

{"title":"Cordyceps militaris Ethanol Extract Alleviates Hyperglycemia in Type 2 Diabetic Mice in Association With Gut Microbiota Modification","authors":"Huanhuan Wen, Wenke Hu, Xinru Xu, Na Wu, Huangcong Ding, Haonan Wang, Xiaoyu Gao, Ligen Chen, Chao Zhao, Rong Shao, Wei Xu","doi":"10.1002/efd2.70175","DOIUrl":"https://doi.org/10.1002/efd2.70175","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder characterized by hyperglycemia and gut microbiota dysbiosis. This study evaluated the therapeutic effects of Cordyceps militaris ethanol extract (CME) on glycemic control and gut microbiota in a T2DM mouse model. After a 4-week intervention, CME administration effectively ameliorated hyperglycemia, glucose intolerance, dyslipidemia and pancreatic islet dysfunction. Concurrently, CME treatment was associated with favorable alterations in the gut microbiota, notably a reduced Bacillota/Bacteroidota ratio and increased relative abundance of short-chain fatty acid (SCFA)-producing genera including Eubacterium-ventriosum-group, Butyribacter and Candidatus-Soleaferrea, which correlated with elevated SCFAs concentrations. In addition, CME treatment was associated with enhanced expression of akt-1 and glut-2, which might be associated with increased SCFAs levels. These findings suggest that the observed upregulation of akt-1 and glut-2 expression may be linked to alterations in gut microbiota composition and increased SCFAs levels, which correlate with alleviated hyperglycemia. Correlation analysis further revealed that Lachnospiraceae-NK4B4-group, Candidatus Soleaferrea, Eubacterium-ventriosum-group and Anaeroplasma were highly correlated with multiple hyperglycemia-related biochemical indicators, suggesting their potential as microbial biomarkers for T2DM. Our findings provide correlational evidence supporting the potential of CME as a therapeutic agent.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotic Stability and Antihypertensive Activity of Peptides in Aguamiel Syrup-Fortified Milk Protein Fermented by Lacticasebacillus rhamnosus GG 鼠李糖乳杆菌GG发酵的水果糖强化乳蛋白中多肽的益生菌稳定性和降压活性

IF 5.7

eFood Pub Date : 2026-06-16 DOI: 10.1002/efd2.70173

Olvera-Rosales Laura Berenice, Leonel-Enríquez Jorge Eduardo, Pérez-Escalante Emmanuel, Castañeda-Ovando Araceli, Contreras-López Elizabeth, Cruz-Guerrero Alma Elizabeth, González-Olivares Luis Guillermo

{"title":"Probiotic Stability and Antihypertensive Activity of Peptides in Aguamiel Syrup-Fortified Milk Protein Fermented by Lacticasebacillus rhamnosus GG","authors":"Olvera-Rosales Laura Berenice, Leonel-Enríquez Jorge Eduardo, Pérez-Escalante Emmanuel, Castañeda-Ovando Araceli, Contreras-López Elizabeth, Cruz-Guerrero Alma Elizabeth, González-Olivares Luis Guillermo","doi":"10.1002/efd2.70173","DOIUrl":"https://doi.org/10.1002/efd2.70173","url":null,"abstract":"Population growth and increasing interest in health-promoting foods have stimulated the development of synbiotic products with benefits beyond basic nutrition. This study evaluated aguamiel syrup as a functional ingredient in a synbiotic fermented dairy product, focusing on its ability to enhance antihypertensive peptide release and support the viability of Lacticaseibacillus rhamnosus GG. A skimmed milk powder solution (10% w/v) was supplemented with 2% aguamiel syrup, while 2% inulin served as the control prebiotic. Fermentation was conducted for 48 h, monitoring probiotic viability, pH, lactic acid production, proteolytic activity, and angiotensin-converting enzyme (ACE) inhibitory activity. Although no significant differences were observed in metabolic parameters or free amino group concentrations, the aguamiel system promoted greater production of low-molecular-weight peptides associated with enhanced antihypertensive activity. The aguamiel fermentation reached 41.6% ACE inhibition at 36 h, whereas the inulin control exhibited 20.4% inhibition at 0 h and no detectable activity after 36 h. Additionally, aguamiel syrup accelerated acidification and promoted higher final cell densities, indicating improved fermentation performance. These findings suggest that aguamiel syrup is a promising prebiotic ingredient for synbiotic dairy products with potential antihypertensive applications and relevance for functional food development.","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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