eFood最新文献

{"title":"Valorization of Fruit Waste Through Reutilization Approach: A Comprehensive Review","authors":"Rupesh Kaushik,&nbsp;Sonia Morya,&nbsp;Omar Bashir,&nbsp;Jehangir H. Bhadha,&nbsp;Ladislaus Manaku Kasankala","doi":"10.1002/efd2.70073","DOIUrl":"10.1002/efd2.70073","url":null,"abstract":"<p>The shift towards a circular economy presents opportunities to minimize waste and maximize resource efficiency, particularly in the context of fruit waste. This review explores the innovative utilization of fruit waste globally, highlighting its potential to enhance sustainability. It discusses the types, quantities, and compositions of waste generated by the fruit industry. Current waste management practices, such as composting, biogas production, and their use as animal feed, are examined as important strategies for reducing environmental impact. The potential for fruit waste to create value-added products is explored in depth, including applications in food packaging, agriculture, water purification, and the extraction of bioactive compounds for pharmaceutical and nutraceutical uses. The role of fruit waste in the food sector is also discussed, with particular attention to the utilization of bioactive compounds and incorporation into bakery products, illustrating its potential to improve food quality and sustainability. It further discusses emerging technologies, challenges, and policy frameworks in waste management. The importance of fruit waste utilization in fostering a sustainable future is highlighted, aligning with global efforts to reduce waste and promote resource circularity. By integrating innovative solutions and cross-sector collaborations, fruit waste can be transformed into a valuable resource in the circular economy.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Surface Methodology Optimization on Ultrasonic-Assisted Extraction of Chicory (Cichorium intybus L.) and Their UPLC-ESI-QTOF-MS Analysis, Antioxidant and Hepatoprotective Activity","authors":"Aizhamal Baiseitova,&nbsp;Ulpan Amzeyeva,&nbsp;Aiya Tolepbergen,&nbsp;Yasmina Ulfanova,&nbsp;Yergazy Shybyray,&nbsp;Lixia Dai,&nbsp;Xiaofei Shang,&nbsp;Abdul Bari Shah,&nbsp;Jeong Yoon Kim,&nbsp;Janar Jenis","doi":"10.1002/efd2.70081","DOIUrl":"10.1002/efd2.70081","url":null,"abstract":"<p>Chicory (<i>Cichorium intybus</i> L<i>.</i>) roots are commonly roasted and ground to produce a coffee alternative, valued for its robust, nutty taste and absence of caffeine. Historically, it has been utilized to facilitate digestion, serve as a diuretic, and promote liver function. This study employed a response surface methodology (RSM) for optimization the ultrasonic-assisted extraction of antioxidant composition from chicory. The optimal extraction conditions (temperature 60°C, extraction duration 4 h, and solid-to-solvent ratio of 1:20 g/mL) resulted in the maximum yield and antioxidant capacity. The metabolic content of chicory extract, prepared under optimal conditions, was found by UPLC-ESI-QTOF/MS, including aesculetin, caftaric acid, caffeoylmalic acid, scopoletin, and chicoric acid. Moreover, chicory extracts derived under identical conditions in two distinct solvents (96% and 50% ethanol) demonstrated vitality and hepatoprotective action in HL-7702 cells. This study may offer a perspective for acquiring potential extracts of chicory as a functional food.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ganoderma Sinense Soluble Dietary Fiber Alleviates Nonalcoholic Fatty Liver Disease by Regulating Liver Metabolism","authors":"Ping Shao,&nbsp;Ying Yang,&nbsp;Zhenhao Li,&nbsp;Jihong Yang,&nbsp;Guoliang Zhang,&nbsp;Jianhua Zhang,&nbsp;Mengyao Wang","doi":"10.1002/efd2.70079","DOIUrl":"10.1002/efd2.70079","url":null,"abstract":"<p><i>Ganoderma sinense</i> possesses a liver-protective effect. Increasing dietary fiber intake can prevent and manage the progression of chronic metabolic syndrome. However, the effects and mechanisms of <i>Ganoderma sinense</i> soluble dietary fiber (GSSDF) on nonalcoholic fatty liver disease (NAFLD) remain unclear. This study analyzed the physicochemical properties of GSSDF, investigated the effects of GSSDF on NAFLD models in vitro and in vivo, and elucidated the underlying molecular mechanisms focusing on hepatic metabolism. The results showed that GSSDF had a loose and porous surface structure and a typical polysaccharide functional group structure. At the same time, it demonstrated excellent water absorption, oil absorption, and swelling properties, which would contribute to reduced fat absorption. GSSDF inhibited liver lipid accumulation and enhanced antioxidant capacity in both in vivo and in vitro NAFLD models. Liver metabolomics analysis revealed that NAFLD was alleviated by the intervention of GSSDF in glycerophospholipid metabolism, which involved upregulating the expression of phosphorylated adenosine monophosphate activated protein kinase (P-AMPK), phosphorylated acetyl-CoA carboxylase (P-ACC), and peroxisome proliferator-activated receptor (PPAR), and downregulating the expression of fatty acid synthase (FASN). It was concluded that GSSDF improved lipid metabolism disorders to prevent NAFLD and obesity, which laid the foundation for developing its potential as a liver-protective dietary supplement for improving NAFLD.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a High-Performance Liquid Chromatography Method for the Determination of Epoxyaurapten From Pomelo Peel","authors":"Hui Ni,&nbsp;Dongfeng Guo,&nbsp;Xue Li,&nbsp;Lijun Li,&nbsp;Yuanfan Yang,&nbsp;Xiping Du,&nbsp;Yang Hu,&nbsp;Shuyu Zhang,&nbsp;Feng Chen,&nbsp;Fan He","doi":"10.1002/efd2.70077","DOIUrl":"10.1002/efd2.70077","url":null,"abstract":"<p>Furanocoumarins found in citrus fruits are recognized for their health benefits, but are also known to induce photosensitivity and allergic reactions. Therefore, it is necessary to establish reliable analytical methods for their quantification. In this study, a high-performance liquid chromatography (HPLC) procedure was developed to quantify epoxyaurapten, a furanocoumarin compound in pomelo peel. The effects of extraction solvent, liquid-to-material ratio, ultrasonic time, and extraction cycles on the extraction of epoxyaurapten from pomelo peel were investigated, and the optimal sample pretreatment conditions were determined to ensure the extraction efficiency. The results indicated a high degree of precision with a linear correlation coefficient of 0.9999. The limits of detection and limits of quantification were determined to be 0.5 and 2 μg/mL, respectively. The spiked recovery ranged from 101.24% to 110.46%, with the precision experiment revealing a standard deviation of 0.20% and stability experiments demonstrating a standard deviation of 1.76%. In addition, the HPLC method was successfully employed to detect the content of epoxyaurapten in different pomelo varieties and their various parts. The results revealed that epoxyaurapten was detected only in the exocarp of pomelo cultivars. This finding gives significant implication for further research on the application of epoxyaurapten in pomelo studies.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “A Comprehensive Review of VOCs as a Key Indicator in Food Authentication”","authors":"","doi":"10.1002/efd2.70070","DOIUrl":"10.1002/efd2.70070","url":null,"abstract":"<p>H. Yang, M. Wu, X. Shen, et al., “A Comprehensive Review of VOCs as a Key Indicator in Food Authentication,” <i>eFood</i> 6 (2025): e70057, https://doi.org/10.1002/efd2.70057.</p><p>The author affiliations were incorrectly published as:</p><p>Han Yang¹ | Manxi Wu¹ | Xinyu Shen¹ | Yichen Lai¹ | Dengliang Wang² | Chao Ma³ | Xianming Ye⁴ | Cui Sun⁵ | Jinping Cao¹ | Chongde Sun¹ | Yu Zhang⁶ | Yue Wang¹</p><p>¹Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Fruit Science Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, Zhejiang, China</p><p>²Institute of Fruit Tree Research, Quzhou Academy of Agriculture and Forestry Science, Quzhou, Zhejiang, China</p><p>³Zhejiang Nongzhen Food Co. Ltd., Quzhou, Zhejiang, China</p><p>⁴Zhejiang Jianong Fruit &amp; Vegetable Co. Ltd., Quzhou, Zhejiang, China</p><p>⁵Hainan Institute of Zhejiang University, Sanya, Hainan, China</p><p>⁶Key Laboratory of Agricultural Product Information Traceability, Ministry of Agriculture and Rural Affairs of China, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, China</p><p>This should have read:</p><p>Han Yang¹ | Manxi Wu¹ | Xinyu Shen¹ | Yichen Lai¹ | Dengliang Wang⁴ | Chao Ma⁵ | Xianming Ye⁶ | Cui Sun³ | Jinping Cao¹ | Chongde Sun¹ | Yu Zhang² | Yue Wang¹</p><p>¹Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Fruit Science Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, Zhejiang, China</p><p>²Key Laboratory of Agricultural Product Information Traceability, Ministry of Agriculture and Rural Affairs of China, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, China</p><p>³Hainan Institute of Zhejiang University, Sanya, Hainan, People's Republic of China</p><p>⁴Institute of Fruit Tree Research, Quzhou Academy of Agriculture and Forestry Science, Quzhou, Zhejiang, China</p><p>⁵Zhejiang Nongzhen Food Co., Ltd., Quzhou, Zhejiang, China</p><p>⁶Zhejiang Jianong Fruit &amp; Vegetable Co., Ltd., Quzhou, Zhejiang, China</p><p>We apologize for this error.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Biodegradation of T-2 Toxin by a Dominant Microbial Consortium Isolated From Chinese Yeast Ball”","authors":"","doi":"10.1002/efd2.70069","DOIUrl":"10.1002/efd2.70069","url":null,"abstract":"<p>C. Yang, N. Mahror, S. Li, L. Liu, and L. Cheng, “Biodegradation of T-2 Toxin by a Dominant Microbial Consortium Isolated From Chinese Yeast Ball,” <i>eFood</i> 6, no. 2 (2025), https://doi.org/10.1002/efd2.70047.</p><p>An author's name was incorrect. Chun-Ming Yang should have been Chun-Min Yang.</p><p>We apologize for this error.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioavailability and Bioaccessibility of Grain Polyphenols: A Comprehensive Review","authors":"Fatima Tariq,&nbsp;Fakhar Islam,&nbsp;Bushra Atique,&nbsp;Ahmed Hussien Alawadi,&nbsp;Subbulakshmi Ganesan,&nbsp;Sana Attique,&nbsp;Ashish Singh Chauhan,&nbsp;Ali Imran,&nbsp;Mohd Asif Shah,&nbsp;Hafiz A. R. Suleria","doi":"10.1002/efd2.70067","DOIUrl":"10.1002/efd2.70067","url":null,"abstract":"<p>Phenolic compounds are highly abundant, heterogeneous substances in plant food sources, especially grains. Wheat contains chlorogenic acid, syringic acid, ferulic acid, and gallic acid, and oats contain polyphenolic compounds such as <i>p</i>-hydroxybenzoic acid, caffeic acid, syringic acid, vanillic acid, and <i>p</i>-coumaric acid. Corn also consists of <i>p</i>-coumaric acid, <i>o</i>-coumaric acid, and gallic acid. Phenols are considered therapeutic agents related to the treatment and treatment of various diseases such as cardiovascular diseases, neurological disorders, cancer, diabetes, Parkinson's, and Alzheimer's, as well as the reduction of anthropometric parameters. Fermentation is used to increase the bioavailability of polyphenols and improve microbial ecology. Encapsulation has recently been ranked as the most effective method for optimal stability and bioavailability of active ingredients. This review explores the role of grain phenolic compounds in bioavailability and bioaccessibility in detail.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halymenia durvillei Extracts Exert Antiobesity Effects by Targeting hosl-1-Mediated Lipolysis in a Glucose-Induced Caenorhabditis elegans Model","authors":"Kawita Chumphoochai,&nbsp;Sukrit Promtang,&nbsp;Pawanrat Chalorak,&nbsp;Preeyanuch Manohong,&nbsp;Nakorn Niamnont,&nbsp;Montakan Tamtin,&nbsp;Prasert Sobhon,&nbsp;Simon Tuck,&nbsp;Krai Meemon","doi":"10.1002/efd2.70065","DOIUrl":"10.1002/efd2.70065","url":null,"abstract":"<p>The antiobesity effect of extracts from the marine algae, <i>Halymenia durvillei</i> (HD), was investigated in a glucose-induced <i>Caenorhabditis elegans</i> model of obesity. Total fat accumulation, triglyceride levels, lifespan, intracellular ROS levels, and the potential mechanism of action of <i>H. durvillei</i> extracts were examined. The present study demonstrated that the ethanol fraction of <i>H. durvillei</i> (HDET) and ethyl acetate fraction of <i>H. durvillei</i> (HDEA) extracts led to a significant reduction in fat accumulation, triglyceride levels, the GFP-labeled <i>dhs-3</i>, a marker for lipid droplets, and the intracellular ROS levels. <i>H. durvillei</i> extracts significantly extended the lifespan of glucose-induced worms. In addition, the mRNA expression of lipolysis-related genes, <i>atgl-1</i> and <i>hosl-1</i>, showed significant upregulation following treatment with <i>H. durvillei</i> extracts. This finding was supported by RNA interference (RNAi) of <i>atgl-1</i> and <i>hosl-1</i>, which resulted in disrupting the effect of the <i>H. durvillei</i> extracts on lowering fat accumulation. Furthermore, transcriptomic analysis revealed diverse metabolic activities in glucose-induced worms treated with HDEA, affecting fatty acid metabolism. The results suggested that these extracts provide an antiobesity effect mediated through the lipolysis genes, <i>atgl-1</i> and <i>hosl-1</i>. <i>H. durvillei</i>-derived extracts may offer valuable insights as functional food ingredients for use in the prevention of obesity.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory and Antioxidant Activities of Polyphenols From Loquat (Eriobotrya japonica Lindl.) Leaf Hair in Lipopolysaccharide-Induced In Vitro and In Vivo Models","authors":"Can Hu,&nbsp;Jiazheng Hu,&nbsp;Hongyu Ye,&nbsp;Mengxin Wang,&nbsp;Manxi Wu,&nbsp;Han Yang,&nbsp;Kang Chen,&nbsp;Jinping Cao,&nbsp;Yanshuai Wang,&nbsp;Yue Wang,&nbsp;Chongde Sun","doi":"10.1002/efd2.70064","DOIUrl":"10.1002/efd2.70064","url":null,"abstract":"<p>This study aimed to characterize polyphenols present in Loquat (<i>Eriobotrya japonica</i> Lindl.) leaf hair (LLH) and evaluate their antioxidant and anti-inflammatory effects in lipopolysaccharide (LPS)-induced inflammation models In Vitro and In Vivo. Ultra-performance liquid chromatography coupled with UPLC-HRMS identified 24 compounds in LLH, including 21 polyphenols, notably revealing the presence of four polymethoxyflavones previously unreported in loquat. Antioxidant evaluations (ABTS, DPPH, FRAP, and ORAC) confirmed robust radical-scavenging and reducing capabilities of LLH extract. In Vitro studies utilizing human liver L02 cells demonstrated that LLH significantly suppressed LPS-induced reactive oxygen species (ROS) generation, preserved antioxidant enzyme activities (CAT, SOD, and GSH-Px), and upregulated antioxidant-related genes (<i>Nrf2</i>, <i>Cat</i>, <i>Sod1</i>, and <i>Gpx1</i>). Furthermore, LLH pretreatment markedly inhibited LPS-induced nitric oxide (NO) release, inflammatory cytokine (IL-1β, IL-6, and TNF-α) production, and downregulated the Jak2–Stat3 inflammatory signaling pathway. Consistently, In Vivo experiments using an LPS-induced acute liver injury mouse model revealed that oral administration of LLH significantly reduced hepatic oxidative stress and inflammation by restoring antioxidant enzyme activities, enhancing <i>Nrf2</i>-mediated antioxidant pathways, and suppressing inflammatory mediators and Jak2–Stat3 signaling in liver. Collectively, these findings demonstrate LLH polyphenols' potent antioxidant and anti-inflammatory effects and suggest their potential as natural functional agents for managing inflammation-related oxidative stress.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Yunnan Guangnan Dendrobium officinale With Different Growth Years Using UHPLC–Orbitrap–MS","authors":"Jiao Zhang,&nbsp;Yanping Ye,&nbsp;Yan Ding,&nbsp;Heng Tian,&nbsp;Xinglian Chen,&nbsp;Kaixi Li,&nbsp;Hongcheng Liu,&nbsp;Tao Lin","doi":"10.1002/efd2.70066","DOIUrl":"10.1002/efd2.70066","url":null,"abstract":"<p><i>Dendrobium officinale</i> from Guangnan was screened nontargeted using UHPLC–Orbitrap-MS for different growth years. OPLS-DA effectively differentiated <i>D. officinale</i> based on growth years, identifying 70 different compounds. Eight indole diketopiperazine alkaloids did not differ considerably among the growth years. The differential compounds of <i>D. officinale</i> with 4 years of growth were more distinct from other years, with 10 compounds showing greater variability. Pathways in cancer, cancer metabolic pathways, metabolic pathways, chemical carcinogenesis—receptor activation were more enriched. This suggests that <i>D. officinale</i> functional compounds have pharmacological activities in these areas and can regulate the metabolic processes of lipids and atherosclerosis.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"6 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}