{"title":"Cordyceps militaris Ethanol Extract Alleviates Hyperglycemia in Type 2 Diabetic Mice in Association With Gut Microbiota Modification","authors":"Huanhuan Wen, Wenke Hu, Xinru Xu, Na Wu, Huangcong Ding, Haonan Wang, Xiaoyu Gao, Ligen Chen, Chao Zhao, Rong Shao, Wei Xu","doi":"10.1002/efd2.70175","DOIUrl":"https://doi.org/10.1002/efd2.70175","url":null,"abstract":"<p>Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder characterized by hyperglycemia and gut microbiota dysbiosis. This study evaluated the therapeutic effects of <i>Cordyceps militaris</i> ethanol extract (CME) on glycemic control and gut microbiota in a T2DM mouse model. After a 4-week intervention, CME administration effectively ameliorated hyperglycemia, glucose intolerance, dyslipidemia and pancreatic islet dysfunction. Concurrently, CME treatment was associated with favorable alterations in the gut microbiota, notably a reduced Bacillota/Bacteroidota ratio and increased relative abundance of short-chain fatty acid (SCFA)-producing genera including <i>Eubacterium-ventriosum</i>-group, <i>Butyribacter</i> and <i>Candidatus-Soleaferrea</i>, which correlated with elevated SCFAs concentrations. In addition, CME treatment was associated with enhanced expression of <i>akt-1</i> and <i>glut-2</i>, which might be associated with increased SCFAs levels. These findings suggest that the observed upregulation of <i>akt-1</i> and <i>glut-2</i> expression may be linked to alterations in gut microbiota composition and increased SCFAs levels, which correlate with alleviated hyperglycemia. Correlation analysis further revealed that <i>Lachnospiraceae-NK4B4</i>-group, <i>Candidatus Soleaferrea</i>, <i>Eubacterium-ventriosum</i>-group and <i>Anaeroplasma</i> were highly correlated with multiple hyperglycemia-related biochemical indicators, suggesting their potential as microbial biomarkers for T2DM. Our findings provide correlational evidence supporting the potential of CME as a therapeutic agent.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olvera-Rosales Laura Berenice, Leonel-Enríquez Jorge Eduardo, Pérez-Escalante Emmanuel, Castañeda-Ovando Araceli, Contreras-López Elizabeth, Cruz-Guerrero Alma Elizabeth, González-Olivares Luis Guillermo
{"title":"Probiotic Stability and Antihypertensive Activity of Peptides in Aguamiel Syrup-Fortified Milk Protein Fermented by Lacticasebacillus rhamnosus GG","authors":"Olvera-Rosales Laura Berenice, Leonel-Enríquez Jorge Eduardo, Pérez-Escalante Emmanuel, Castañeda-Ovando Araceli, Contreras-López Elizabeth, Cruz-Guerrero Alma Elizabeth, González-Olivares Luis Guillermo","doi":"10.1002/efd2.70173","DOIUrl":"https://doi.org/10.1002/efd2.70173","url":null,"abstract":"<p>Population growth and increasing interest in health-promoting foods have stimulated the development of synbiotic products with benefits beyond basic nutrition. This study evaluated aguamiel syrup as a functional ingredient in a synbiotic fermented dairy product, focusing on its ability to enhance antihypertensive peptide release and support the viability of <i>Lacticaseibacillus rhamnosus</i> GG. A skimmed milk powder solution (10% w/v) was supplemented with 2% aguamiel syrup, while 2% inulin served as the control prebiotic. Fermentation was conducted for 48 h, monitoring probiotic viability, pH, lactic acid production, proteolytic activity, and angiotensin-converting enzyme (ACE) inhibitory activity. Although no significant differences were observed in metabolic parameters or free amino group concentrations, the aguamiel system promoted greater production of low-molecular-weight peptides associated with enhanced antihypertensive activity. The aguamiel fermentation reached 41.6% ACE inhibition at 36 h, whereas the inulin control exhibited 20.4% inhibition at 0 h and no detectable activity after 36 h. Additionally, aguamiel syrup accelerated acidification and promoted higher final cell densities, indicating improved fermentation performance. These findings suggest that aguamiel syrup is a promising prebiotic ingredient for synbiotic dairy products with potential antihypertensive applications and relevance for functional food development.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eunju Jang, Tae-Baek Lee, Lisa Tonini, Soobin Choi, YoonA Jeon, Taehyun Kim, Taeyoung Kang, Hyuk-Joon Choi, Changhwan Ahn
{"title":"Pulsed Electric Field Processing Enhances the Endothelial Bioefficacy of Red Beet (Beta vulgaris L.) Extracts by Restoring Endothelial Nitric Oxide Synthase–Nitric Oxide Signaling in High-Fat Diet Rats","authors":"Eunju Jang, Tae-Baek Lee, Lisa Tonini, Soobin Choi, YoonA Jeon, Taehyun Kim, Taeyoung Kang, Hyuk-Joon Choi, Changhwan Ahn","doi":"10.1002/efd2.70174","DOIUrl":"https://doi.org/10.1002/efd2.70174","url":null,"abstract":"<p>Endothelial dysfunction is a central mechanism underlying the development of major cardiovascular diseases, including hypertension and atherosclerosis. Red beet (<i>Beta vulgaris</i> L.)–derived products are widely recognized as functional dietary components that support metabolic and vascular health, and multiple extraction strategies have been explored to optimize their biological efficacy. Pulsed electric field (PEF) processing has emerged as a nonthermal approach capable of enhancing the recovery of plant-derived bioactive compounds by increasing cellular permeability, while avoiding thermal degradation. However, the influence of PEF processing on endothelial-specific outcomes, including NO bioavailability, vascular remodeling, and endothelium-dependent function, has not been systematically investigated. In this study, we examined whether PEF processing qualitatively alters the vascular bioefficacy of red beet extracts in a high-fat diet–induced model of endothelial dysfunction. PEF-treated extracts restored endothelial signaling and improved vascular functional responsiveness to a greater extent than conventionally extracted preparations. Our findings demonstrate that PEF-treated red beet extracts exert superior protective effects on endothelial function compared with non-PEF–treated preparations. These results indicate that processing technology itself represents a biologically relevant determinant of vascular efficacy and highlight the potential of PEF-based approaches to enhance the endothelial benefits of plant-derived functional ingredients.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 4","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farhang Hameed Awlqadr, Mohammed N. Saeed, Ammar B. Altemimi, Ahmad F. Hama Sdiq, Othman Abdulrahman Mohammed, Sonia Morya, Syamand Ahmed Qadir, Tablo H. Salih, Khaled Arab
{"title":"Nano-Engineered Yogurt as a Functional Delivery Platform: From Encapsulation Technologies to Personalized Nutrition","authors":"Farhang Hameed Awlqadr, Mohammed N. Saeed, Ammar B. Altemimi, Ahmad F. Hama Sdiq, Othman Abdulrahman Mohammed, Sonia Morya, Syamand Ahmed Qadir, Tablo H. Salih, Khaled Arab","doi":"10.1002/efd2.70167","DOIUrl":"https://doi.org/10.1002/efd2.70167","url":null,"abstract":"<p>Nanotechnology is being used to enhance bioactive compound stability and bioavailability in yogurt. This review examines the use of various nanoencapsulation systems in the fortification of yogurt with functional ingredients, including nanoemulsions, liposomes, niosomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and biopolymer-based nanocarriers. Key factors considered include encapsulation efficiency, oxidation protection, casein network structural interactions, and gastrointestinal release characteristics. In vitro digestion models (e.g., INFOGEST) provide evidence that nanoencapsulation provides significantly higher bioaccessibility of hydrophobic nutrients compared to their free forms, with improvements of 3–5 times for polyphenols, omega-3 fatty acids, and fat-soluble vitamins. Lipid-based carriers have been shown to provide lipid oxidation protection as well as improve intestinal absorption. Protein–polysaccharide complexes enhance the slow-release properties of probiotic bacteria as well as their ability to survive during passage through the intestines. Also of great importance is that nanoengineered systems maintain yogurt rheological characteristics, water-holding ability, and sensory acceptability. While promising functional benefits, scalability, regulatory approval, and long-term safety of products for industrial use are major challenges remaining.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya
{"title":"Harnessing Fatty Acid By-Products for Diabetes Management: Insights From Nutritional and Biological Research","authors":"Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya","doi":"10.1002/efd2.70162","DOIUrl":"10.1002/efd2.70162","url":null,"abstract":"<p>Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays a pivotal role in its development, influenced by various factors such as age, health status, location, and cultural practices. Health professionals emphasize the importance of a well-balanced diet mitigates the risk of various pathologies, including diabetes. This paper provides a comprehensive review of bioactive fatty acids and their potential antidiabetic effects. Short-, medium- and long-chain fatty acids have shown remarkable ability to reduce hyperlipidemia through mechanisms at the subcellular, cellular, and molecular levels. Recent studies highlight the significant properties of these natural molecules, emphasizing their potential in managing diabetes and preventing diabetogenesis by controlling major risk factors. Incorporating these dietary sources may offer a preventive approach to diabetes. Further investigations are necessary to understand the molecular mechanisms underlying their antidiabetic effects. This review underscores the promising potential of bioactive fatty acids from agro-industrial by-products as a viable avenue for managing diabetes, with the aim of developing targeted interventions for optimized utilization and therapeutic benefits.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148050399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji Young Hwang, Ji Yun Van, Hyeon Hak Jeong, Yerin Seong, Seokmin Lee, Jaeseong Seo, Bo-Mi Ryu, Seungjun Lee, Suhyeon Baek, Sanggil Lee, Won-Kyo Jung, Jae-Il Kim, Bonggi Lee
{"title":"Upcycling Agricultural By-Products: RNA-Seq-Based Elucidation of Body Weight-Independent Hepatoprotective Mechanisms of Cucumis melo var. makuwa Leaf Extract in Diet-Induced Obese Mice","authors":"Ji Young Hwang, Ji Yun Van, Hyeon Hak Jeong, Yerin Seong, Seokmin Lee, Jaeseong Seo, Bo-Mi Ryu, Seungjun Lee, Suhyeon Baek, Sanggil Lee, Won-Kyo Jung, Jae-Il Kim, Bonggi Lee","doi":"10.1002/efd2.70150","DOIUrl":"https://doi.org/10.1002/efd2.70150","url":null,"abstract":"<p>Agricultural by-products are a promising yet underutilized source of functional bioactive compounds. In this study, we evaluated the effects of <i>Cucumis melo</i> var. <i>makuwa</i> leaf (CML) extract on metabolic dysfunction-associated steatotic liver disease (MASLD). In high-fat diet–induced obese mice, supplementation with 0.4% CML extract for 18 weeks reduced hepatic triglyceride and cholesterol levels by 55.9% and 37.8%, respectively, without altering body weight or energy expenditure. CML extract significantly improved hepatic steatosis, oxidative stress, and serum ALT levels, showing more pronounced hepatoprotective effects than <i>Garcinia cambogia</i>. Transcriptomic analysis of primary hepatocytes revealed modulation of lipid transport and extracellular matrix–related processes, alongside suppression of IL-17 and cytokine signaling. These changes were associated with reduced ROS/ONOO<sup>−</sup> production and decreased expression of proinflammatory mediators. LC–MS profiling identified soyacerebroside I and Glu–Glu–Arg as candidate bioactive components. Overall, our findings demonstrate that oriental melon leaves, an agricultural waste product, exert direct hepatoprotective effects independent of weight change and represent a sustainable functional ingredient for MASLD management within a circular bioeconomy framework.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148238150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Bolchini, Parham Joolaei Ahranjani, Maria Concetta Tenuta, Sabrina Vorderegger, Sissy Häsler Gunnarsdottir, Anja Schuster, Giovanna Ferrentino
{"title":"Valorization of Raspberry (Rubus Idaeus L.) Leaves via Ultrasound-Assisted Extraction and Preparative HPLC Fractionation: Antioxidant Kinetics, Antimicrobial Activity, and Performance in Bulk Oils and Pickering Emulsions","authors":"Sara Bolchini, Parham Joolaei Ahranjani, Maria Concetta Tenuta, Sabrina Vorderegger, Sissy Häsler Gunnarsdottir, Anja Schuster, Giovanna Ferrentino","doi":"10.1002/efd2.70168","DOIUrl":"10.1002/efd2.70168","url":null,"abstract":"<p>Raspberry (<i>Rubus idaeus</i> L.) leaves are an abundant agri-food by-product with high potential as a source of natural bioactive compounds. In this study, ultrasound-assisted extraction (UAE) was applied as a green approach to recover phenolic-rich extracts, which were subsequently characterized by HPLC–DAD and high-resolution mass spectrometry (HPLC–HRMS). To elucidate structure–activity relationships, the extract was fractionated by preparative HPLC into phenolic acid/catechin-, ellagitannin-, and flavonoid-rich fractions. Antioxidant activity was evaluated using conventional spectrophotometric assays, kinetic stopped-flow DPPH measurements, and isothermal calorimetry in bulk sunflower oil and Pickering emulsions stabilized by zein nanoparticles. The ellagitannin-rich fraction, dominated by sanguiin H-6, exhibited the highest radical scavenging activity and largely accounted for the antioxidant behavior of the whole extract. While moderate inhibition of lipid oxidation was observed in bulk oil, a marked enhancement of antioxidant efficiency and induction time was achieved in Pickering emulsions, highlighting the importance of interfacial localization effects. Antimicrobial activity tests showed significant inhibition of Gram-positive foodborne pathogens, particularly <i>Bacillus cereus</i> and <i>Staphylococcus aureus</i>. Overall, this work demonstrates the potential of raspberry leaves as a sustainable source of multifunctional bioactives and underscores the role of green extraction, fractionation, and appropriate delivery systems in maximizing their effectiveness for food applications.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148049952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gaia Giannitti, Sara Marchesi, Riccardo Garavaglia, Ivan Preosto, Fabrizio Fontana
{"title":"δ-Tocotrienol Inhibits Migration and Reduces Chemoresistance in Ovarian Cancer Stem-Like Cells","authors":"Gaia Giannitti, Sara Marchesi, Riccardo Garavaglia, Ivan Preosto, Fabrizio Fontana","doi":"10.1002/efd2.70166","DOIUrl":"10.1002/efd2.70166","url":null,"abstract":"<p>Ovarian cancer (OC) is the most lethal form of gynecologic malignancies, due to its intrinsic chemoresistance and ability to relapse. Cancer stem cells (CSCs) are the main responsible for this fatal aggressiveness. δ-Tocotrienol (δ-TT) is an extensively studied anti-tumor compound; however, its role in affecting ovarian CSC proliferation has not been elucidated yet. Herein, we demonstrated that a sphere-forming cell population enriched in stem-like features can be isolated from IGROV-1 and SKOV-3 cell lines; in particular, this subgroup was shown to possess higher migratory capacity and chemoresistance when compared to the non-stem counterpart. Notably, δ-TT was found to suppress OC stem-like traits, namely clonogenic and spherogenic ability as well as embryonic marker expression and ABCG2 enrichment. In addition, it significantly disrupted the migration of OC stem-like populations via modulation of epithelial-to-mesenchymal transition (EMT) and increased their sensitivity to cisplatin. At the molecular level, Akt and NF-κB downregulation was observed in treated spheroids. Collectively, these findings highlight novel inhibitory effects of δ-TT on OC stem-like cells, thus offering new perspectives into its anti-cancer potential.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148049332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Davide Laurenti, Daniel Di Risola, Antonio Francioso, Rodolfo Federico, Eugenio Lendaro, Riccardo Gasbarrone, Giuseppe Bonifazi, Mario Fontana, Luciana Mosca, Roberto Mattioli
{"title":"An Innovative Strategy to Enhance Polyphenol Content and Quality Traits of Olive Oil and Valorization of Mill Wastewater","authors":"Davide Laurenti, Daniel Di Risola, Antonio Francioso, Rodolfo Federico, Eugenio Lendaro, Riccardo Gasbarrone, Giuseppe Bonifazi, Mario Fontana, Luciana Mosca, Roberto Mattioli","doi":"10.1002/efd2.70156","DOIUrl":"10.1002/efd2.70156","url":null,"abstract":"<p>Olive oil polyphenols are a valuable help for human health and producing high-quality extra virgin olive oil rich in these polyphenols is a key objective for many farmers. In this work, we evaluated the impact of addition of salts to the milling process to increase the polyphenolic content of olive oil. The procedure proved successful, with efficacy dependent on the specific salt used and its concentration. The use of salts, in both laboratory and industrial settings, has increased not only the polyphenol content within the oil but also the yield and the qualitative–quantitative, sensory and nutritional characteristics of olive oil by impacting the amount of other minor constituents of olive oil, such as volatile compounds, chlorophyll, and carotenoids. Using the same approach, and by utilizing wastewater as a source of bioactives, we also successfully enriched other seed oils with olive oil polyphenols minimizing the waste of these substances and valorizing them. This enabled us to obtain a new class of seed oils enriched in antioxidant and anti-inflammatory compounds, potentially representing a new frontier in nutraceuticals.</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148048734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Waqar, Mariyam Shahid, Manat Chaijan, Worawan Panpipat, Djilali Benabdelmoumene, Ahmed Mediani, Abdifetah Ibrahim Omar, Sabrin R. M. Ibrahim, Qudrat Ullah, Temesgen Anjulo Ageru
{"title":"Artificial Intelligence in the Food Industry: Transforming Safety, Efficiency, and Sustainability From Farm to Fork","authors":"Muhammad Waqar, Mariyam Shahid, Manat Chaijan, Worawan Panpipat, Djilali Benabdelmoumene, Ahmed Mediani, Abdifetah Ibrahim Omar, Sabrin R. M. Ibrahim, Qudrat Ullah, Temesgen Anjulo Ageru","doi":"10.1002/efd2.70161","DOIUrl":"10.1002/efd2.70161","url":null,"abstract":"<p>Artificial intelligence (AI) is promptly changing the nature of food production and processing to increase safety, efficiency, quality assurance, and sustainability throughout the farm-to-fork chain. This review discusses the recent developments in AI in the food manufacturing industry, such as machine learning (ML), deep learning (Dl), computer vision (CV), hyperspectral imaging (HSI), robotics, Internet-of-Things (IoT) integration, and natural language processing. These technologies allow detecting contamination and fraud in real-time, near-perfect predictive maintenance less 30% unplanned downtime, automated quality checks with up to 96%–100% accuracy, AI-enabled predictive maintenance (PdM) has demonstrated its effectiveness by decreasing unplanned downtime in industrial case studies through a reduction rate that reaches 30% of total downtime, resource-efficient smart factories, and creative AI-driven formulation of products. New paradigms include digital twins, explainable AI, computational gastronomy, and cultured meat production, highlighting the transformative power of AI. Some of the solutions include standardized datasets, lightweight architectures, federated learning, and scalable deployment training programs. When used responsibly, AI can help create food systems that meet regulatory requirements while achieving sustainable development goals and circular economy standards, and all three Sustainable Development Goals, like Zero Hunger (SDG 2), Responsible Consumption and Production (SDG 12), and Climate Action (SDG 13).</p>","PeriodicalId":11436,"journal":{"name":"eFood","volume":"7 3","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/efd2.70161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148048736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}